MCID: FNG004
MIFTS: 34

Fungal Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Fungal Meningitis

MalaCards integrated aliases for Fungal Meningitis:

Name: Fungal Meningitis 12 3 15
Meningitis, Fungal 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11608
MeSH 44 D016921
SNOMED-CT 68 24321005
UMLS 73 C0085438

Summaries for Fungal Meningitis

Disease Ontology : 12 A meningitis that has material basis in a fungal infection.

MalaCards based summary : Fungal Meningitis, also known as meningitis, fungal, is related to meningitis and hematopoietic stem cell transplantation. An important gene associated with Fungal Meningitis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-17 Family Signaling Pathways. The drugs Fluconazole and Sertraline have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lung, and related phenotype is cardiovascular system.

CDC : 3 Español: Meningitis micótica

Wikipedia : 76 Fungal meningitis refers to meningitis caused by a fungal... more...

Related Diseases for Fungal Meningitis

Diseases related to Fungal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.9 CCL2 IFNG IL10
2 hematopoietic stem cell transplantation 29.9 IFNG IL10
3 cryptococcal meningitis 11.1
4 cryptococcosis 10.2 IFNG UNC119
5 cephalosporin allergy 10.2 IFNG IL10
6 hyperlucent lung 10.2 IFNG IL10
7 sporotrichosis 10.2 IFNG IL10
8 nickel allergic contact dermatitis 10.2 IFNG IL10
9 baylisascariasis 10.2 IFNG IL10
10 penicillin allergy 10.2 IFNG IL10
11 chronic graft versus host disease 10.2 IFNG IL10
12 clonorchiasis 10.2 IFNG IL10
13 pericardial tuberculosis 10.2 IFNG IL10
14 tuberculoid leprosy 10.2 IFNG IL10
15 chronic active epstein-barr virus infection 10.1 IFNG IL10
16 fascioliasis 10.1 IFNG IL10
17 intermediate uveitis 10.1 IFNG IL10
18 orofacial granulomatosis 10.1 IFNG IL10
19 buruli ulcer 10.1 IFNG IL10
20 hand, foot and mouth disease 10.1 IFNG IL10
21 mycoplasma pneumoniae pneumonia 10.1 IFNG IL10
22 poliomyelitis 10.1 IFNG IL10
23 eales disease 10.1 IFNG IL10
24 hemorrhagic fever 10.1 IFNG IL10
25 coccidiosis 10.1 IFNG IL10
26 aseptic meningitis 10.1 IFNG IL10
27 asymptomatic neurosyphilis 10.1 CXCL10 IFNG
28 plasmodium vivax malaria 10.1 IFNG IL10
29 polyradiculoneuropathy 10.1 IFNG IL10
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 IFNG IL10
31 coccidioidomycosis 10.1 CYP51A1 IL10
32 q fever 10.1 IFNG IL10
33 acute graft versus host disease 10.1 IFNG IL10
34 paranasal sinus disease 10.1 FLNC IFNG IL10
35 immune system disease 10.1 FLNC IFNG IL10
36 lepromatous leprosy 10.0 IFNG IL10
37 scleritis 10.0 CCL2 IFNG
38 neurosyphilis 10.0 CXCL10 IL10
39 testicular disease 10.0 IFNG IL10
40 apple allergy 10.0 CXCL10 IL10
41 nonspecific interstitial pneumonia 10.0 CCL2 IFNG
42 invasive aspergillosis 10.0 CXCL10 FLNC IFNG
43 pleural tuberculosis 10.0 CCL2 IFNG
44 mixed connective tissue disease 10.0 IFNG IL10
45 acute pyelonephritis 10.0 CXCL10 IL10
46 tick-borne encephalitis 10.0 CXCL10 IL10
47 palladium allergic contact dermatitis 10.0 CCL2 IL10
48 echinococcosis 10.0 IFNG IL10
49 peanut allergy 9.9 CXCL10 IFNG IL10
50 spotted fever 9.9 CXCL10 IFNG IL10

Graphical network of the top 20 diseases related to Fungal Meningitis:



Diseases related to Fungal Meningitis

Symptoms & Phenotypes for Fungal Meningitis

MGI Mouse Phenotypes related to Fungal Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 CXCL10 CYP51A1 FLNC GPR180 IFNG IL10

Drugs & Therapeutics for Fungal Meningitis

Drugs for Fungal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
2
Sertraline Approved Phase 3 79617-96-2 68617
3
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
4 Liposomal amphotericin B Phase 3
5 Neurotransmitter Uptake Inhibitors Phase 3
6 Psychotropic Drugs Phase 3
7 Serotonin Uptake Inhibitors Phase 3
8 Serotonin Agents Phase 3
9 Neurotransmitter Agents Phase 3
10 Antidepressive Agents Phase 3
11
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Completed NCT01802385 Phase 3 Sertraline

Search NIH Clinical Center for Fungal Meningitis

Cochrane evidence based reviews: meningitis, fungal

Genetic Tests for Fungal Meningitis

Anatomical Context for Fungal Meningitis

MalaCards organs/tissues related to Fungal Meningitis:

41
Brain, Testes, Lung, Skin, Bone, T Cells

Publications for Fungal Meningitis

Articles related to Fungal Meningitis:

(show top 50) (show all 68)
# Title Authors Year
1
Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. ( 29244019 )
2018
2
Epidemiological Effectiveness and Cost of a Fungal Meningitis Outbreak Response in New River Valley, Virginia: Local Health Department and Clinical Perspectives. ( 28578748 )
2017
3
Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review. ( 26681583 )
2016
4
Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation. ( 27258644 )
2016
5
Causes and root causes of a multistate fungal meningitis outbreak. ( 25616150 )
2015
6
(1,3)-I^-d-glucan in cerebrospinal fluid for diagnosis of fungal meningitis associated with contaminated methylprednisolone injections. ( 25540391 )
2015
7
Lack of IL-6 increases blood-brain barrier permeability in fungal meningitis. ( 25740137 )
2015
8
Estimated deaths and illnesses averted during fungal meningitis outbreak associated with contaminated steroid injections, United States, 2012-2013. ( 25989264 )
2015
9
Economic Evaluation of Fungal Meningitis Outbreak Response in New River Valley: Local Health Department Perspective. ( 26317059 )
2015
10
Utility of real-time PCR for detection of Exserohilum rostratum in body and tissue fluids during the multistate outbreak of fungal meningitis and other infections. ( 25520443 )
2015
11
Utility of (1-3)-I^-D-Glucan Testing for Diagnostics and Monitoring Response to Treatment During the Multistate Outbreak of Fungal Meningitis and Other Infections. ( 24336827 )
2014
12
Whole-genome analysis of Exserohilum rostratum from an outbreak of fungal meningitis and other infections. ( 24951807 )
2014
13
Fungal meningitis in England and Wales. ( 25253404 )
2014
14
Unraveling the biology of a fungal meningitis pathogen using chemical genetics. ( 25416953 )
2014
15
Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study. ( 24508198 )
2014
16
How gaps in regulation of compounding pharmacy set the stage for a multistate fungal meningitis outbreak. ( 25063265 )
2014
17
Iatrogenic fungal meningitis. ( 23460069 )
2013
18
Index case for the fungal meningitis outbreak, United States. ( 23465121 )
2013
19
Vogt-koyanagi-harada disease and fungal meningitis. ( 25383811 )
2013
20
Fungal meningitis outbreak affects over 700. ( 23602160 )
2013
21
Notes from the field: Department of Defense response to a multistate outbreak of fungal meningitis--United States, October 2012. ( 24067586 )
2013
22
The fungal meningitis tragedy: implications for pharmacy education and the profession. ( 23460756 )
2013
23
Hospital faces uncertainty as it copes with surge of patients with fungal meningitis. ( 23321741 )
2013
24
Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis. ( 24012946 )
2013
25
Cerebrospinal fluid (1,3)-I^-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis. ( 23363831 )
2013
26
Fungal meningitis outbreak. ( 23358084 )
2013
27
Detection of fungal DNA in human body fluids and tissues during a multistate outbreak of fungal meningitis and other infections. ( 23457192 )
2013
28
Index case for the fungal meningitis outbreak, United States. ( 23465120 )
2013
29
Vascular complications of fungal meningitis attributed to injections of contaminated methylprednisolone acetate. ( 23877880 )
2013
30
A real-time PCR assay for rapid detection and quantification of Exserohilum rostratum, a causative pathogen of fungal meningitis associated with injection of contaminated methylprednisolone. ( 23303500 )
2013
31
Fungal meningitis in an immunocompetent patient. ( 23381985 )
2013
32
Early clinical observations in prospectively followed patients with fungal meningitis related to contaminated epidural steroid injections. ( 23183583 )
2013
33
Relapse of fungal meningitis associated with contaminated methylprednisolone. ( 23718153 )
2013
34
Fungal meningitis outbreak editorial. ( 24095660 )
2013
35
Exserohilum rostratum fungal meningitis associated with methylprednisolone injections. ( 23374119 )
2013
36
Index case for the fungal meningitis outbreak, United States. ( 23465119 )
2013
37
Fungal meningitis due to contaminated epidural steroid injections. ( 23221857 )
2012
38
Multistate fungal meningitis outbreak -- interim guidance for treatment. ( 23076094 )
2012
39
Iatrogenic fungal meningitis: tragedy repeated. ( 23080380 )
2012
40
Fungal meningitis from injection of contaminated steroids: a compounding problem. ( 23104261 )
2012
41
Chronic fungal meningitis caused by Aureobasidium proteae. ( 22504065 )
2012
42
The index case for the fungal meningitis outbreak in the United States. ( 23083311 )
2012
43
Assessment of a real-time PCR method to detect human non-cryptococcal fungal meningitis. ( 22039841 )
2011
44
Bacterial and fungal meningitis and antimicrobial susceptibility pattern in Tikur Anbessa University Hospital, Addis Ababa, Ethiopia. ( 23409400 )
2011
45
A new method for the treatment of chronic fungal meningitis: continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. ( 19506457 )
2009
46
Bacterial and fungal meningitis in patients with cancer. ( 18347316 )
2008
47
Epidemiologic and microbiologic characteristics of recurrent bacterial and fungal meningitis in the Netherlands, 1988-2005. ( 18643757 )
2008
48
Life-threatening fungal meningitis-ventriculitis secondary to vaginal candidiasis. ( 17554958 )
2007
49
World's first reported outbreak of iatrogenic fungal meningitis. ( 17802991 )
2007
50
Prevalence of fungal meningitis among HIV positive & negative subjects in Indore (MP state). ( 12645168 )
2002

Variations for Fungal Meningitis

Expression for Fungal Meningitis

Search GEO for disease gene expression data for Fungal Meningitis.

Pathways for Fungal Meningitis

GO Terms for Fungal Meningitis

Biological processes related to Fungal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.46 CCL2 CXCL10 IFNG IL10
2 leukocyte chemotaxis GO:0030595 9.26 CXCL10 IL10
3 cellular response to lipopolysaccharide GO:0071222 9.13 CCL2 CXCL10 IL10
4 regulation of signaling receptor activity GO:0010469 8.92 CCL2 CXCL10 IFNG IL10

Molecular functions related to Fungal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL2 CXCL10 IFNG IL10

Sources for Fungal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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