Aliases & Classifications for Funisitis

MalaCards integrated aliases for Funisitis:

Name: Funisitis 12 15 70

External Ids:

Disease Ontology 12 DOID:0050698
UMLS 70 C1275592

Summaries for Funisitis

Disease Ontology : 12 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

MalaCards based summary : Funisitis is related to syphilis and vasculitis. An important gene associated with Funisitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include placenta, thymus and brain, and related phenotypes are cardiovascular system and neoplasm

Wikipedia : 73 Funisitis is inflammation of the connective tissue of the umbilical cord that occurs with... more...

Related Diseases for Funisitis

Diseases related to Funisitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 683)
# Related Disease Score Top Affiliating Genes
1 syphilis 30.4 TNF IL6 CRP
2 vasculitis 30.0 TNF SELE IL6 CRP
3 enterocolitis 29.9 TNF IL6 IL10 CXCL8
4 candidiasis 29.7 TNF IL6 IL1B IL10 CXCL8
5 exudative vitreoretinopathy 1 29.6 TNF IL6 IL1B COL18A1 ANGPT1
6 asphyxia neonatorum 29.5 OXT IL6 CRP
7 perinatal necrotizing enterocolitis 29.3 TNF IL6 IL1B IL10 CXCL8 CRP
8 meconium aspiration syndrome 29.2 TNF OXT IL6 CXCL8
9 cerebral palsy 29.2 TNF SELE MMP8 IL6 IL1B IL10
10 chorioamnionitis 29.1 TNF S100A12 OXT MMP8 IL6 IL1B
11 bronchopneumonia 29.0 TNF IL6 IL1B IL10 CXCL8 CRP
12 atherosclerosis susceptibility 29.0 TNF SELE IL6 IL1B CXCL8 CRP
13 proteasome-associated autoinflammatory syndrome 1 29.0 TNF SELE IL6 IL1B IL10 CXCL8
14 preterm premature rupture of the membranes 28.7 TNF OXT MMP8 IL6 IL1B IL10
15 respiratory failure 28.7 TNF MMP8 IL6 IL1B IL10 CXCL8
16 placenta disease 28.6 TNF OXT IL6 IL1B CXCL8 CRP
17 lung disease 28.4 TNF S100A8 MMP8 IL6 IL1B IL10
18 pre-eclampsia 28.3 TNF SELE OXT IL6 IL1B IL10
19 fuchs' heterochromic uveitis 10.4 IL6 CXCL8
20 acute pericementitis 10.4 IL1B CXCL8
21 acute cervicitis 10.4 IL10 CXCL8
22 indolent plasma cell myeloma 10.4 IL6 IL1B
23 neurosyphilis 10.4 IL10 CXCL8
24 anaerobic pneumonia 10.3 IL6 IL1B
25 transient arthritis 10.3 IL6 IL1B
26 eye lymphoma 10.3 IL6 IL10
27 acute retinal necrosis syndrome 10.3 IL6 IL10
28 glomeruloid hemangioma 10.3 IL6 IL1B
29 baritosis 10.3 IL1B CXCL8
30 acute monoblastic leukemia 10.3 IL6 CXCL8
31 congenital syphilis 10.3
32 acute transverse myelitis 10.3 IL6 IL10 CXCL8
33 acute gonococcal cervicitis 10.3 IL6 IL10 CXCL8
34 recurrent corneal erosion 10.3 IL6 IL1B CXCL8
35 squamous blepharitis 10.3 SELE S100A8
36 conjunctivochalasis 10.3 IL6 IL1B CXCL8
37 ascaris lumbricoides infection 10.3 IL6 IL1B CXCL8
38 human cytomegalovirus infection 10.2 IL6 IL1B CXCL8
39 radiculopathy 10.2 IL6 IL10 CXCL8
40 denture stomatitis 10.2 IL6 CXCL8
41 cold agglutinin disease 10.2 IL6 CRP
42 cysticercosis 10.2 IL6 IL1B IL10
43 systemic autoimmune disease 10.2 IL6 CRP
44 cryopyrin-associated periodic syndrome 10.2 IL6 CRP
45 covid-19 10.2 IL6 IL1B CXCL8
46 external pathological resorption 10.2 TNF IL6
47 slow-channel congenital myasthenic syndrome 10.2 CXCL8 CRP
48 pericoronitis 10.2 IL1B CRP
49 bone sarcoma 10.2 IL6 IL10 CXCL8
50 scorpion envenomation 10.2 TNF IL6

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to Funisitis

Symptoms & Phenotypes for Funisitis

MGI Mouse Phenotypes related to Funisitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ANGPT1 COL18A1 CRP IL10 IL1B IL6
2 neoplasm MP:0002006 9.1 COL18A1 IL10 IL1B IL6 MMP8 TNF

Drugs & Therapeutics for Funisitis

Search Clinical Trials , NIH Clinical Center for Funisitis

Genetic Tests for Funisitis

Anatomical Context for Funisitis

MalaCards organs/tissues related to Funisitis:

40
Placenta, Thymus, Brain, Monocytes, Neutrophil, Ovary, Endothelial

Publications for Funisitis

Articles related to Funisitis:

(show top 50) (show all 371)
# Title Authors PMID Year
1
Presence of Chlamydia trachomatis DNA in the amniotic fluid in women with preterm prelabor rupture of membranes. 61
31272257 2021
2
Degree of intrapartum fever and associated factors: Three group analysis of no fever, borderline and overt fever. 61
33438353 2021
3
Placenta Pathology From Term Born Neonates With Normal or Adverse Outcome. 61
33470918 2021
4
The Contribution of an Infectious Workup in Understanding Stillbirth. 61
31600792 2021
5
Labor dystocia and risk of histological chorioamnionitis and funisitis: a study from a single tertiary referral center. 61
33784970 2021
6
Clinical chorioamnionitis at term X: microbiology, clinical signs, placental pathology, and neonatal bacteremia - implications for clinical care. 61
33544519 2021
7
Exposure to intrauterine inflammation and late-onset sepsis in very preterm infants. 61
33731804 2021
8
Florid Bacillus cereus Infection of the Placenta Associated With Intrauterine Fetal Demise. 61
33729850 2021
9
Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease. 61
33557386 2021
10
Use of mean platelet volume in the assessment of intrauterine infection in newborns with combined thrombocytopenia and leukopenia at birth. 61
30983434 2021
11
Impact of chorioamnionitis on maternal and fetal levels of proinflammatory S100A12. 61
32514673 2021
12
Klebsiella pneumoniae Chorioamnionitis: An Underrecognized Cause of Preterm Premature Rupture of Membranes in the Second Trimester. 61
33401648 2021
13
RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection. 61
33152737 2021
14
10 cases of umbilical cord thrombosis in the third trimester. 61
33389094 2021
15
Clinical predictive factors of histological chorioamnionitis: case-control study. 61
33364485 2020
16
Gestational Age Dependency of Umbilical Cord Serum IL-6 Levels for Detecting Fetal Inflammation. 61
33242909 2020
17
Placental histopathological features of fetoscopic laser photocoagulation for monoaminotic diamniotic twin pregnancies. 61
32980047 2020
18
Early- and Late-Respiratory Outcome in Very Low Birth Weight with or without Intrauterine Inflammation. 61
32898888 2020
19
The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications. 61
33164775 2020
20
Fetal inflammatory response is positively correlated with the progress of inflammation in chorionic plate. 61
32792065 2020
21
Antenatal thymus volumes in fetuses that delivered <32 weeks gestation: An MRI pilot study. 61
32865812 2020
22
Therapeutic interventions for fetal inflammatory response syndrome (FIRS). 61
32303464 2020
23
Maternal inflammatory markers for chorioamnionitis in preterm prelabour rupture of membranes: a systematic review and meta-analysis of diagnostic test accuracy studies. 61
32532314 2020
24
MiR-29b is associated with perinatal inflammation in extremely preterm infants. 61
32386397 2020
25
Risk of brain damage in premature infants under 34 weeks of gestational age exposed to histological chorioamnionitis Lima, Peru. 61
32876210 2020
26
A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim. 61
32184236 2020
27
Influence of maternal and placental factors on newborn body composition. 61
31392795 2020
28
Placental histopathology in late preterm infants: clinical implications. 61
31431602 2020
29
Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression. 61
32582153 2020
30
Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection. 61
33211747 2020
31
Stillbirth Associated With Infection in a Diverse U.S. Cohort. 61
31764728 2019
32
Acute Funisitis Correlates With the Risk of Early-Onset Sepsis in Term Newborns Assessed Using the Kaiser Sepsis Calculator. 61
31166881 2019
33
Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study. 61
31693497 2019
34
Parallel detection of lactobacillus and bacterial vaginosis-associated bacterial DNA in the chorioamnion and vagina of pregnant women at term. 61
29478370 2019
35
Streptococcus pneumoniae - An Uncommon but Noteworthy Cause of Intrauterine Fetal Demise and Acute Necrotizing Funisitis. 61
30942119 2019
36
Prevalence, Morphology, Embryogenesis, and Diagnostic Utility of Umbilical Cord Vitelline Vascular Remnants. 61
30541420 2019
37
Maternal Epidural Steroids to Prevent Neonatal Exposure to Hyperthermia and Inflammation. 61
30388714 2019
38
Inflammation-mediated fetal injury by maternal granulocyte-colony stimulating factor and high-dose intraamniotic endotoxin in the caprine model. 61
31019839 2019
39
Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study. 61
31263446 2019
40
Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy in the Absence of Sentinel Events. 61
29579759 2019
41
Influence of foetal inflammation on the development of meconium aspiration syndrome in term neonates with meconium-stained amniotic fluid. 61
31183262 2019
42
The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis. 61
31743377 2019
43
Association between clinical chorioamnionitis and histological funisitis at term. 61
30040750 2019
44
Isolated acute funisitis in the absence of acute chorioamnionitis: What does it mean? 61
30712665 2019
45
Impact of different stages of intrauterine inflammation on outcome of preterm neonates: Gestational age-dependent and -independent effect. 61
30735531 2019
46
Prenatal diagnosis of funisitis: two case reports. 61
29396737 2018
47
Gastric fluid used to assess changes during the latency period in preterm prelabor rupture of membranes. 61
29892034 2018
48
Histologic Funisitis and Likelihood of Intrauterine Inflammation or Infection: A Case-Control Study. 61
29365327 2018
49
Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study. 61
29193660 2018
50
Prediction of chorioamnionitis in cases of intraamniotic infection by ureaplasma urealyticum in women with very preterm premature rupture of membranes or preterm labour. 61
28502201 2018

Variations for Funisitis

Expression for Funisitis

Search GEO for disease gene expression data for Funisitis.

Pathways for Funisitis

Pathways related to Funisitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF S100A8 S100A12 MMP8 IL6 IL1B
2
Show member pathways
13.29 TNF IL6 IL1B IL10 CXCL8 ANGPT1
3
Show member pathways
13.23 TNF IL6 IL1B IL10 CXCL8 ANGPT1
4
Show member pathways
13.15 TNF SELE IL6 IL1B IL10 CXCL8
5
Show member pathways
12.81 TNF IL6 IL1B IL10 CXCL8
6
Show member pathways
12.56 TNF IL6 IL1B IL10 ANGPT1
7
Show member pathways
12.55 TNF IL6 IL1B IL10
8
Show member pathways
12.54 TNF IL6 IL1B IL10
9
Show member pathways
12.32 TNF S100A8 IL6 IL1B CXCL8
10
Show member pathways
12.3 TNF IL6 IL10 CXCL8
11
Show member pathways
12.3 TNF IL6 IL1B CRP
12
Show member pathways
12.28 TNF IL6 IL1B CXCL8
13
Show member pathways
12.24 TNF IL6 IL1B IL10 CXCL8
14 12.21 TNF IL6 IL1B CXCL8
15 12.21 TNF IL6 IL1B IL10
16
Show member pathways
12.18 TNF IL6 IL1B IL10
17
Show member pathways
12.16 TNF IL6 IL1B CXCL8
18 12.16 TNF IL6 IL1B IL10 CXCL8
19 12.07 TNF IL6 IL1B IL10 CXCL8
20 11.99 TNF IL6 IL1B CXCL8
21 11.96 TNF SELE IL6 IL1B
22 11.95 TNF IL6 IL10
23 11.95 TNF IL6 IL1B IL10 CXCL8
24 11.9 IL6 IL1B CXCL8
25 11.89 TNF IL1B CXCL8
26 11.88 TNF IL6 IL1B IL10 CXCL8
27
Show member pathways
11.86 TNF MMP8 COL18A1
28 11.86 TNF IL6 IL1B
29 11.85 TNF SELE IL6 IL1B CXCL8
30 11.77 SELE IL6 CXCL8
31
Show member pathways
11.77 TNF IL6 IL1B IL10
32 11.77 TNF IL6 IL1B CXCL8 ANGPT1
33 11.76 TNF IL1B IL10
34 11.75 TNF IL6 IL1B IL10
35 11.67 TNF IL6 IL10
36 11.67 TNF IL6 IL1B CXCL8
37 11.65 TNF IL6 IL1B IL10 CXCL8
38 11.61 TNF IL6 IL1B CXCL8
39 11.57 SELE IL6 CXCL8
40 11.48 TNF IL6 IL1B
41
Show member pathways
11.45 TNF SELE IL6 IL1B CXCL8
42 11.36 TNF IL6 IL1B IL10
43 11.3 TNF IL6 IL1B
44 11.28 TNF IL6 IL1B
45 11.24 TNF IL6 IL1B IL10 CXCL8
46 11.2 TNF IL6 IL1B IL10
47 10.97 TNF IL6 IL1B IL10 CXCL8 COL18A1
48 10.92 TNF IL1B
49 10.92 TNF SELE IL6 IL1B IL10
50 10.9 TNF IL6 CXCL8 CRP

GO Terms for Funisitis

Cellular components related to Funisitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF S100A8 S100A12 OXT MMP8 IL6
2 collagen-containing extracellular matrix GO:0062023 9.46 S100A8 MMP8 COL18A1 ANGPT1
3 extracellular space GO:0005615 9.44 TNF SELE S100A8 S100A12 OXT MMP8

Biological processes related to Funisitis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.04 TNF IL6 IL1B IL10 CXCL8
2 negative regulation of cell proliferation GO:0008285 10.02 IL6 IL1B IL10 CXCL8 COL18A1
3 defense response to bacterium GO:0042742 9.96 TNF S100A8 S100A12 IL10
4 extracellular matrix organization GO:0030198 9.96 TNF MMP8 ICAM3 COL18A1
5 cytokine-mediated signaling pathway GO:0019221 9.95 TNF IL6 IL1B IL10 CXCL8
6 response to lipopolysaccharide GO:0032496 9.9 SELE S100A8 IL1B IL10
7 defense response to Gram-positive bacterium GO:0050830 9.86 TNF IL6 CRP
8 regulation of inflammatory response GO:0050727 9.86 TNF SELE S100A8
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 TNF IL6 ANGPT1
10 positive regulation of JNK cascade GO:0046330 9.85 TNF MMP8 IL1B
11 neutrophil chemotaxis GO:0030593 9.84 S100A8 S100A12 CXCL8
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 TNF IL6 IL1B IL10
13 positive regulation of inflammatory response GO:0050729 9.83 TNF S100A8 S100A12 IL1B
14 cellular response to lipopolysaccharide GO:0071222 9.83 TNF IL6 IL1B IL10 CXCL8
15 regulation of insulin secretion GO:0050796 9.82 TNF IL6 IL1B
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.82 TNF MMP8 IL1B
17 positive regulation of interleukin-8 production GO:0032757 9.81 TNF IL6 IL1B
18 positive regulation of interleukin-6 production GO:0032755 9.81 TNF MMP8 IL6 IL1B
19 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNF S100A8 S100A12 IL6 IL1B
20 response to activity GO:0014823 9.79 OXT IL6 IL10
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF MMP8 IL1B
22 response to glucocorticoid GO:0051384 9.76 TNF OXT IL6 IL10
23 positive regulation of JAK-STAT cascade GO:0046427 9.75 TNF IL6 IL10
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 TNF IL1B ANGPT1
25 negative regulation of neurogenesis GO:0050768 9.73 TNF IL6 IL1B
26 embryonic digestive tract development GO:0048566 9.7 TNF CXCL8
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 TNF IL1B
28 positive regulation of gene expression GO:0010628 9.7 TNF MMP8 IL6 IL1B CXCL8 CRP
29 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.69 TNF IL6
30 leukocyte migration involved in inflammatory response GO:0002523 9.69 SELE S100A8
31 regulation of neuroinflammatory response GO:0150077 9.68 MMP8 IL6
32 response to molecule of bacterial origin GO:0002237 9.68 IL10 CXCL8
33 regulation of establishment of endothelial barrier GO:1903140 9.67 TNF IL1B
34 positive regulation of prostaglandin secretion GO:0032308 9.67 OXT IL1B
35 positive regulation of glial cell proliferation GO:0060252 9.67 TNF IL6 IL1B
36 endothelial cell apoptotic process GO:0072577 9.65 TNF IL10
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 TNF IL1B IL10
38 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
39 regulation of microglial cell activation GO:1903978 9.61 MMP8 IL6
40 sequestering of triglyceride GO:0030730 9.61 TNF IL1B
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IL1B
42 negative regulation of lipid storage GO:0010888 9.54 TNF IL6 CRP
43 vascular endothelial growth factor production GO:0010573 9.5 TNF IL6 IL1B
44 negative regulation of cytokine production involved in immune response GO:0002719 9.43 TNF IL10 ANGPT1
45 positive regulation of neuroinflammatory response GO:0150078 9.26 TNF MMP8 IL6 IL1B
46 inflammatory response GO:0006954 9.23 TNF SELE S100A8 S100A12 IL6 IL1B

Molecular functions related to Funisitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IL10 CXCL8
2 RAGE receptor binding GO:0050786 8.96 S100A8 S100A12

Sources for Funisitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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