Aliases & Classifications for Funisitis

MalaCards integrated aliases for Funisitis:

Name: Funisitis 12 15 73

External Ids:

Disease Ontology 12 DOID:0050698
UMLS 73 C1275592

Summaries for Funisitis

Disease Ontology : 12 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

MalaCards based summary : Funisitis is related to chorioamnionitis and preterm premature rupture of the membranes. An important gene associated with Funisitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Atosiban and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and brain, and related phenotype is neoplasm.

Wikipedia : 76 Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause... more...

Related Diseases for Funisitis

Diseases related to Funisitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 chorioamnionitis 30.8 CXCL8 IL1B IL6 MMP8
2 preterm premature rupture of the membranes 30.1 CXCL8 IL1B IL6 MMP8
3 lung disease 29.4 CXCL8 IL10 IL1B IL6 MMP8
4 mastitis 10.2 CXCL8 IL6
5 hemorrhagic fever with renal syndrome 10.2 CXCL8 IL6
6 obstructive jaundice 10.2 CXCL8 IL6
7 interstitial cystitis 10.2 CXCL8 IL6
8 avian influenza 10.2 CXCL8 IL6
9 bacterial pneumonia 10.2 CXCL8 IL6
10 conjunctivitis 10.2 CXCL8 IL6
11 shigellosis 10.2 CXCL8 IL10
12 nose disease 10.2 CXCL8 IL10
13 syphilis 10.2
14 vasculitis 10.2
15 congenital syphilis 10.2
16 melioidosis 10.2 IL10 IL6
17 rheumatic heart disease 10.2 IL10 IL6
18 autoimmune disease of musculoskeletal system 10.2 IL10 IL6
19 sleeping sickness 10.2 IL10 IL6
20 filariasis 10.2 IL10 IL6
21 spondyloarthropathy 10.2 IL10 IL6
22 paracoccidioidomycosis 10.2 IL10 IL6
23 tropical spastic paraparesis 10.2 IL10 IL6
24 uveal disease 10.2 IL10 IL6
25 mixed connective tissue disease 10.2 IL10 IL6
26 human immunodeficiency virus infectious disease 10.2 IL10 IL6
27 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6
28 denture stomatitis 10.2 CXCL8 IL6
29 papillary conjunctivitis 10.2 CXCL8 IL6
30 helicobacter pylori infection 10.2 CXCL8 IL1B
31 silicosis 10.2 CXCL8 IL1B
32 gastric ulcer 10.2 CXCL8 IL1B
33 duodenal ulcer 10.2 CXCL8 IL1B
34 atrophic gastritis 10.2 CXCL8 IL1B
35 acute monoblastic leukemia 10.2 CXCL8 IL6
36 tungiasis 10.2 CXCL8 IL10
37 hemorrhagic fever 10.2 IL10 IL6
38 capillary leak syndrome 10.2 CXCL8 IL6
39 pouchitis 10.2 CXCL8 IL10
40 vulvovaginitis 10.2 CXCL8 IL10
41 carpal tunnel syndrome 10.2 IL1B IL6
42 scabies 10.2 CXCL8 IL10
43 intervertebral disc disease 10.2 IL1B IL6
44 neurosyphilis 10.2 CXCL8 IL10
45 chikungunya 10.2 IL1B IL6
46 necatoriasis 10.2 CXCL8 IL10
47 meconium aspiration syndrome 10.2 CXCL8 IL6
48 lyme disease 10.2 IL1B IL6
49 typhoid fever 10.2 IL1B IL6
50 pericarditis 10.2 IL1B IL6

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to Funisitis

Symptoms & Phenotypes for Funisitis

MGI Mouse Phenotypes related to Funisitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 COL18A1 IL10 IL1B IL6 MMP8

Drugs & Therapeutics for Funisitis

Drugs for Funisitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Atosiban Approved, Investigational Phase 3 90779-69-4
2
Ethanol Approved Phase 3 64-17-5 702
3 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
4 Oxytocics Phase 3,Not Applicable
5 Vasoconstrictor Agents Phase 3
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Early Phase 1
7 Hormone Antagonists Phase 3,Early Phase 1
8 Tocolytic Agents Phase 3
9 Hormones Phase 3,Early Phase 1
10 Vasotocin Phase 3
11
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
12
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
13 Expectorants Phase 1, Phase 2
14 Antiviral Agents Phase 1, Phase 2
15 N-monoacetylcystine Phase 1, Phase 2
16 Free Radical Scavengers Phase 1, Phase 2
17 Anti-Infective Agents Phase 1, Phase 2
18 Antioxidants Phase 1, Phase 2
19 Respiratory System Agents Phase 1, Phase 2
20 Protective Agents Phase 1, Phase 2,Early Phase 1
21 Antidotes Phase 1, Phase 2
22
Oxytocin Approved, Vet_approved Not Applicable 50-56-6 439302 53477758
23
Methylprednisolone hemisuccinate Approved Early Phase 1 2921-57-5
24
Methylprednisolone Approved, Vet_approved Early Phase 1 83-43-2 6741
25
Prednisolone phosphate Approved, Vet_approved Early Phase 1 302-25-0
26
Prednisolone Approved, Vet_approved Early Phase 1 50-24-8 5755
27
Prednisolone hemisuccinate Experimental Early Phase 1 2920-86-7
28 Methylprednisolone acetate Early Phase 1
29 Antiemetics Early Phase 1
30 Antineoplastic Agents, Hormonal Early Phase 1
31 glucocorticoids Early Phase 1
32 Autonomic Agents Early Phase 1
33 Prednisolone acetate Early Phase 1
34 Neuroprotective Agents Early Phase 1
35 Anti-Inflammatory Agents Early Phase 1
36 Gastrointestinal Agents Early Phase 1
37 Peripheral Nervous System Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
2 A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour Terminated NCT02292771 Phase 3 Retosiban;Atosiban;Placebo matching retosiban;Placebo matching atosiban
3 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
4 Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes Completed NCT02702297
5 FOLCROM Trial: Foley Catheter in Rupture of Membranes Completed NCT01973036 Not Applicable Oxytocin
6 Microbiome And Multi'Omics In Preterm Birth: The Bacteria And Birth Study Recruiting NCT02392650
7 Maternal Epidural Steroids and Hyperthemia Terminated NCT02212210 Early Phase 1 Methylprednisolone;Normal saline

Search NIH Clinical Center for Funisitis

Genetic Tests for Funisitis

Anatomical Context for Funisitis

MalaCards organs/tissues related to Funisitis:

41
Placenta, Lung, Brain, Bone, Heart, Lymph Node, Eye

Publications for Funisitis

Articles related to Funisitis:

(show top 50) (show all 79)
# Title Authors Year
1
Prenatal diagnosis of funisitis: two case reports. ( 29396737 )
2018
2
Association between clinical chorioamnionitis and histological funisitis at term. ( 30040750 )
2018
3
Histologic Funisitis and Likelihood of Intrauterine Inflammation or Infection: A Case-Control Study. ( 29365327 )
2018
4
Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis. ( 28161060 )
2017
5
Elevated C-reactive protein levels in histological chorioamnionitis at term: impact of funisitis on term neonates. ( 27450900 )
2016
6
Histologic Chorioamnionitis and Funisitis After Laser Surgery for Twin-Twin Transfusion Syndrome. ( 27399997 )
2016
7
Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis. ( 27814345 )
2016
8
Funisitis is associated with adverse neonatal outcome in low-risk unselected deliveries at or near term. ( 26868144 )
2016
9
Prognostic value of funisitis and/or chorionic vasculitis compared to histologic chorioamnionitis in full-term infants. ( 27023390 )
2016
10
Preterm labor and preterm premature rupture of membranes have a different pattern in the involved compartments of acute histologoic chorioamnionitis and/or funisitis: Patho-physiologic implication related to different clinical manifestations. ( 27090052 )
2016
11
Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes. ( 26812854 )
2016
12
Differential amniotic fluid cytokine profile in women with chorioamnionitis with and without funisitis. ( 26372455 )
2015
13
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. ( 26428501 )
2015
14
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. ( 26373262 )
2015
15
Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity. ( 26352071 )
2015
16
Acute funisitis is associated with distinct changes in fetal hematologic profile. ( 24863633 )
2015
17
Is there a stepwise increase in neonatal morbidities according to histological stage (or grade) of acute chorioamnionitis and funisitis?: effect of gestational age at delivery. ( 25153209 )
2014
18
Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth. ( 24155097 )
2013
19
The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. ( 23489073 )
2013
20
A fetal and an intra-amniotic inflammatory response is more severe in preterm labor than in preterm PROM in the context of funisitis: unexpected observation in human gestations. ( 23658737 )
2013
21
Postnatal changes of cytokines in premature infants with or without funisitis. ( 24246233 )
2013
22
Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. ( 22690100 )
2012
23
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. ( 22639995 )
2012
24
Maternal C-reactive protein at hospital admission is a simple predictor of funisitis in preterm premature rupture of membranes. ( 22710247 )
2012
25
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. ( 22574855 )
2012
26
Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics. ( 22046977 )
2012
27
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. ( 22372866 )
2012
28
Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report. ( 21766037 )
2011
29
The presence of funisitis is associated with a decreased risk for the development of neonatal respiratory distress syndrome. ( 21216461 )
2011
30
Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants. ( 21354722 )
2011
31
Funisitis and risk for the development of neonatal respiratory distress syndrome. ( 21531459 )
2011
32
Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes. ( 21392243 )
2011
33
Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants a8o32 weeks of gestation. ( 21183270 )
2011
34
Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. ( 20528214 )
2011
35
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis. ( 21645958 )
2011
36
Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring. ( 22059462 )
2011
37
The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. ( 20698737 )
2011
38
Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. ( 20727688 )
2010
39
Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. ( 19127216 )
2009
40
Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis. ( 18353056 )
2008
41
The antenatal identification of funisitis with a rapid MMP-8 bedside test. ( 19127606 )
2008
42
Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. ( 18405341 )
2008
43
Ureaplasma urealyticum and Mycoplasma hominis presence in umbilical cord is associated with pathogenesis of funisitis. ( 18204300 )
2007
44
Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. ( 17314690 )
2007
45
Umbilical cord hematoma: association with chorioamnionitis and funisitis. ( 17611840 )
2007
46
Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. ( 17957156 )
2007
47
Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation. ( 17127492 )
2006
48
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. ( 16459014 )
2006
49
Chorioamnionitis with or without funisitis increases the risk of hypotension in very low birthweight infants on the first postnatal day but not later. ( 16624881 )
2006
50
Funisitis and raised interleukin 6 concentrations in gastric aspirates at birth. ( 16036897 )
2005

Variations for Funisitis

Expression for Funisitis

Search GEO for disease gene expression data for Funisitis.

Pathways for Funisitis

Pathways related to Funisitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 ANGPT1 CXCL8 IL10 IL1B IL6 MMP8
2
Show member pathways
13.62 ANGPT1 COL18A1 CXCL8 IL10 IL1B IL6
3
Show member pathways
13.45 ANGPT1 CXCL8 IL10 IL1B IL6
4
Show member pathways
13.31 ANGPT1 CXCL8 IL10 IL1B IL6
5
Show member pathways
13.19 ANGPT1 CXCL8 IL10 IL1B IL6
6
Show member pathways
13.14 ANGPT1 CXCL8 IL10 IL1B IL6
7
Show member pathways
13.09 ANGPT1 CXCL8 IL10 IL1B IL6
8
Show member pathways
12.83 CXCL8 IL10 IL1B IL6
9
Show member pathways
12.7 CXCL8 IL10 IL1B IL6
10
Show member pathways
12.42 IL10 IL1B IL6
11
Show member pathways
12.42 ANGPT1 IL10 IL1B IL6
12
Show member pathways
12.27 IL10 IL1B IL6
13
Show member pathways
12.18 CXCL8 IL1B IL6
14
Show member pathways
12.16 CXCL8 IL1B IL6
15
Show member pathways
12.1 CXCL8 IL10 IL1B IL6
16 12.09 IL10 IL1B IL6
17
Show member pathways
12.08 CXCL8 IL1B IL6
18
Show member pathways
12.06 IL10 IL1B IL6
19
Show member pathways
12.04 CXCL8 IL1B IL6
20
Show member pathways
12.04 COL18A1 CXCL8 IL1B MMP8
21 12.01 CXCL8 IL10 IL1B IL6
22
Show member pathways
11.92 IL10 IL1B IL6
23 11.87 CXCL8 IL1B IL6
24
Show member pathways
11.84 ANGPT1 CXCL8 IL10 IL1B IL6
25 11.81 CXCL8 IL1B IL6
26 11.81 CXCL8 IL10 IL1B IL6
27 11.78 CXCL8 IL1B IL6
28 11.71 CXCL8 IL1B IL6
29 11.69 CXCL8 IL10 IL1B IL6
30 11.62 IL10 IL1B IL6
31 11.62 ANGPT1 CXCL8 IL1B IL6
32 11.59 IL10 IL1B IL6
33 11.53 CXCL8 IL1B IL6
34
Show member pathways
11.52 CXCL8 IL1B IL6
35 11.5 CXCL8 IL10 IL1B IL6
36 11.45 CXCL8 IL6
37 11.45 CXCL8 IL1B IL6
38 11.42 CXCL8 IL6
39 11.38 IL1B IL6
40 11.37 CXCL8 IL6
41 11.35 IL1B IL6
42 11.24 IL1B IL6
43 11.24 IL10 IL1B IL6
44 11.23 IL10 IL1B IL6
45 11.22 CXCL8 IL6
46 11.19 IL1B IL6
47 11.17 IL1B IL6
48 11.15 CXCL8 IL10 IL1B IL6
49 11.12 IL10 IL1B IL6
50 10.95 CXCL8 IL10 IL1B IL6

GO Terms for Funisitis

Cellular components related to Funisitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ANGPT1 COL18A1 CXCL8 IL10 IL1B IL6
2 extracellular space GO:0005615 9.17 ANGPT1 COL18A1 CXCL8 IL10 IL1B IL6

Biological processes related to Funisitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.81 CXCL8 IL10 IL1B IL6
2 response to drug GO:0042493 9.78 COL18A1 IL10 IL1B
3 regulation of signaling receptor activity GO:0010469 9.78 CXCL8 IL10 IL1B IL6
4 angiogenesis GO:0001525 9.76 ANGPT1 COL18A1 CXCL8
5 inflammatory response GO:0006954 9.73 CXCL8 IL10 IL1B IL6
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.63 IL10 IL1B IL6
7 cytokine-mediated signaling pathway GO:0019221 9.62 CXCL8 IL10 IL1B IL6
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.61 IL1B MMP8
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.6 IL1B MMP8
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.59 ANGPT1 IL10
11 negative regulation of neurogenesis GO:0050768 9.58 IL1B IL6
12 leukocyte chemotaxis GO:0030595 9.57 CXCL8 IL10
13 positive regulation of neutrophil chemotaxis GO:0090023 9.56 CXCL8 IL1B
14 positive regulation of glial cell proliferation GO:0060252 9.55 IL1B IL6
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.54 ANGPT1 IL1B
16 response to glucocorticoid GO:0051384 9.54 IL10 IL1B IL6
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL10 IL1B
18 response to molecule of bacterial origin GO:0002237 9.49 CXCL8 IL10
19 cellular response to lipopolysaccharide GO:0071222 9.46 CXCL8 IL10 IL1B IL6
20 positive regulation of interleukin-6 production GO:0032755 9.43 IL1B IL6 MMP8
21 negative regulation of cytokine secretion involved in immune response GO:0002740 9.4 ANGPT1 IL10
22 negative regulation of cell proliferation GO:0008285 9.35 COL18A1 CXCL8 IL10 IL1B IL6
23 positive regulation of neuroinflammatory response GO:0150078 8.8 IL1B IL6 MMP8

Molecular functions related to Funisitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL1B IL6

Sources for Funisitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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