MCID: FSR001
MIFTS: 31

Fusariosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Fusariosis

MalaCards integrated aliases for Fusariosis:

Name: Fusariosis 12 59 15 73
Fusarium Infection 59

Characteristics:

Orphanet epidemiological data:

59
fusariosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050289
Orphanet 59 ORPHA228119
UMLS via Orphanet 74 C0276758
ICD10 via Orphanet 34 B48.7
UMLS 73 C0276758

Summaries for Fusariosis

Disease Ontology : 12 An opportunistic mycosis that involves localized or hematogenously disseminated fungal infection by Fusarium solani or Fusarium oxysporum. Skin lesions are seen in neutropenic patients, and indolent cellulitis or soft-tissue necrosis occur in immunocompromised patients at the site of trauma.

MalaCards based summary : Fusariosis, also known as fusarium infection, is related to leukemia and leukemia, acute lymphoblastic. An important gene associated with Fusariosis is POLR2A (RNA Polymerase II Subunit A), and among its related pathways/superpathways is Epstein-Barr virus infection. The drugs Dexamethasone and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, myeloid and bone.

Wikipedia : 76 Fusariosis is an infection seen in neutropenic patients, and is a significant opportunistic pathogen in... more...

Related Diseases for Fusariosis

Diseases related to Fusariosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 leukemia 10.3
2 leukemia, acute lymphoblastic 10.2
3 lymphoblastic leukemia 10.2
4 hematopoietic stem cell transplantation 10.1
5 leukemia, acute myeloid 10.0
6 endophthalmitis 10.0
7 myeloid leukemia 10.0
8 aspergillosis 10.0
9 acute leukemia 10.0
10 scedosporiosis 9.9
11 eumycotic mycetoma 9.8 IFNG TEF
12 neuroblastoma 9.7
13 aplastic anemia 9.7
14 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.7
15 neutropenia 9.7
16 lymphoma 9.7
17 meningoencephalitis 9.7
18 ecthyma 9.7
19 cryptococcosis 9.7
20 candidiasis 9.7
21 panniculitis 9.7
22 aortic aneurysm 9.7
23 aortitis 9.7
24 pyomyositis 9.7
25 aneurysm 9.7
26 primary bacterial infectious disease 9.3 EEF2 IFNG
27 gastrointestinal system disease 9.3 IFNG TEF
28 visceral leishmaniasis 9.2 EEF2 IFNG

Graphical network of the top 20 diseases related to Fusariosis:



Diseases related to Fusariosis

Symptoms & Phenotypes for Fusariosis

Drugs & Therapeutics for Fusariosis

Drugs for Fusariosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2 Anti-Bacterial Agents Phase 3,Not Applicable
3 Antiemetics Phase 3
4 Anti-Infective Agents Phase 3,Not Applicable
5 Anti-Inflammatory Agents Phase 3
6 Antineoplastic Agents, Hormonal Phase 3
7 Autonomic Agents Phase 3
8 BB 1101 Phase 3
9 Dexamethasone acetate Phase 3 1177-87-3
10 Gastrointestinal Agents Phase 3
11 glucocorticoids Phase 3
12 HIV Protease Inhibitors Phase 3
13 Hormone Antagonists Phase 3,Not Applicable
14 Hormones Phase 3,Not Applicable
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
16 Peripheral Nervous System Agents Phase 3
17
protease inhibitors Phase 3
18
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
19
Posaconazole Approved, Investigational, Vet_approved Not Applicable 171228-49-2 147912
20
Voriconazole Approved, Investigational Not Applicable 137234-62-9 71616
21
Caspofungin Approved Not Applicable 179463-17-3, 162808-62-0 468682 2826718
22 Antifungal Agents Not Applicable
23 Antiparasitic Agents Not Applicable
24 Antiprotozoal Agents Not Applicable
25 Cytochrome P-450 CYP3A Inhibitors Not Applicable
26 Cytochrome P-450 Enzyme Inhibitors Not Applicable
27 Steroid Synthesis Inhibitors Not Applicable
28 Cytochrome P-450 CYP2C9 Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3 Standard antimicrobial therapy;G-CSF/dexamethasone
2 Fusariosis in Solid-Organ Transplant Recipients Completed NCT00518778
3 Anti-mold Azole in the Prophylaxis for Invasive Fusariosis Completed NCT02714504 Not Applicable Voriconazole or posaconazole
4 Fusarium Keratitits in Spain 2012 to 2014 Completed NCT02984904
5 Sautour PHRC IR 2008 Completed NCT02859831
6 Validation of an Index of Neutropenia (D-index) in Febrile Neutropenic Cancer Patients Terminated NCT00982540 Not Applicable caspofungin as preemptive antifungal therapy

Search NIH Clinical Center for Fusariosis

Genetic Tests for Fusariosis

Anatomical Context for Fusariosis

MalaCards organs/tissues related to Fusariosis:

41
Skin, Myeloid, Bone, T Cells, Testes, Bone Marrow, Neutrophil

Publications for Fusariosis

Articles related to Fusariosis:

(show top 50) (show all 153)
# Title Authors Year
1
Airborne transmission of invasive fusariosis in patients with hematologic malignancies. ( 29698435 )
2018
2
Recent Advances in the Treatment of Scedosporiosis and Fusariosis. ( 29912161 )
2018
3
Invasive mould disease in haematologic patients: comparison between fusariosis and aspergillosis. ( 29787890 )
2018
4
Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia. ( 29438132 )
2018
5
Disseminated cutaneous fusariosis in human immunodeficiency virus-infected patient and dramatic response with oral itraconazole. ( 29327700 )
2018
6
Fusariosis in a Captive South American Sea Lion (Otaria flavescens): A Case Report. ( 29761326 )
2018
7
Tackling maize fusariosis: in search of Fusarium graminearum biosuppressors. ( 29934785 )
2018
8
Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation. ( 29373264 )
2018
9
Fluorine-18-fluorodeoxyglucose PET/CT in hematopoietic stem cell transplant patients with fusariosis: initial findings of a case series review. ( 29652746 )
2018
10
Lipopeptides produced by Bacillus subtilis as new biocontrol products against fusariosis in ornamental plants. ( 28528498 )
2017
11
A rare case of subcutaneous fusariosis in an immunocompetent patient. ( 28166614 )
2017
12
Sudden blindness as an initial manifestation of localized fusariosis in ethmoid sinus and optic nerve. ( 28752393 )
2017
13
Current antifungal treatment of fusariosis. ( 28705676 )
2017
14
Breakthrough fusariosis presenting initially with pyomyositis. ( 27914686 )
2017
15
Melanization of Fusarium keratoplasticum (F. solani Species Complex) During Disseminated Fusariosis in a Patient with Acute Leukemia. ( 28616680 )
2017
16
Disseminated Fusariosis in Immunocompromised Children-Analysis of Recent Cases Identified in the Global Fungiscope Registry. ( 27846057 )
2017
17
Epidemiological Study of Fusarium Species Causing Invasive and Superficial Fusariosis in Japan. ( 28250364 )
2017
18
A Fortuitous Turn of Evidence in an Elderly Female - A Case of Pulmonary Fusariosis. ( 28384871 )
2017
19
The Use of FDG PET-CT Imaging for the Assessment of Early Antifungal Treatment Response in Disseminated Fusariosis. ( 28481795 )
2017
20
New Insights for Diagnosis of Pineapple Fusariosis by MALDI-TOF MS Technique. ( 27117163 )
2016
21
Successful Treatment of Disseminated Fusariosis with the Combination of Voriconazole and Liposomal Amphotericin B. ( 27311328 )
2016
22
The current treatment landscape: other fungal diseases (cryptococcosis, fusariosis and mucormycosis). ( 27880667 )
2016
23
Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant. ( 27698695 )
2016
24
Fusariosis in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature. ( 27008433 )
2016
25
Antimold Prophylaxis May Reduce the Risk of Invasive Fusariosis in Hematologic Patients with Superficial Skin Lesions with Positive Culture for Fusarium. ( 27671065 )
2016
26
Discrimination of aspergillosis, mucormycosis, fusariosis and scedosporiosis in formalin-fixed paraffin-embedded tissue specimens using multiple real-time quantitative PCR assays. ( 27605714 )
2016
27
Detection of Fusarium-specific T cells in hematologic patients with invasive fusariosis. ( 28017824 )
2016
28
A Case of Cutaneous Fusariosis of the Scrotum as a Complication of Acute Myeloid Leukemia. ( 27251318 )
2016
29
Disseminated fusariosis by Fusarium proliferatum in a patient with aplastic anaemia receiving primary posaconazole prophylaxis - case report and review of the literature. ( 26661324 )
2016
30
Fusarium musae infected banana fruits as potential source of human fusariosis: May occur more frequently than we might think and hypotheses about infection. ( 27195070 )
2016
31
Banana fruits affected by Fusarium post-harvest disease as source of human fusariosis. ( 27682849 )
2016
32
An outbreak of invasive fusariosis in a children's cancer hospital. ( 25658562 )
2015
33
Disseminated fusariosis and hematologic malignancies, a still devastating association. Report of three new cases. ( 25936697 )
2015
34
Invasive Fusariosis: A Single Pediatric Center 15-Year Experience. ( 26407418 )
2015
35
Cutaneous Fusariosis in Unprotected Snake Bite Wound of Farmer's Hand. ( 25798406 )
2015
36
Disseminated fusariosis. ( 25435178 )
2015
37
Risk factors for invasive fusariosis in patients with acute myeloid leukemia and in hematopoietic cell transplant recipients. ( 25425628 )
2015
38
Invasive Fusariosis in the Voriconazole Era: Single-Center 13-Year Experience. ( 26258156 )
2015
39
Role of granulocyte transfusions in invasive fusariosis: systematic review and single-center experience. ( 25857209 )
2015
40
Disseminated fusariosis with endophthalmitis after skin trauma in acute lymphoblastic leukaemia. ( 26395131 )
2015
41
Fusariosis. ( 26398537 )
2015
42
Airway complication contributing to disseminated fusariosis after lung transplantation. ( 24890670 )
2014
43
Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing. ( 24489964 )
2014
44
Murine model for Fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence. ( 24587124 )
2014
45
Treatment and outcomes of invasive fusariosis: review of 65 cases from the PATH Alliance(Ar) registry. ( 24943384 )
2014
46
Banana infecting fungus, Fusarium musae, is also an opportunistic human pathogen: Are bananas potential carriers and source of fusariosis? ( 25361833 )
2014
47
Superficial skin lesions positive for Fusarium are associated with subsequent development of invasive fusariosis. ( 23994063 )
2014
48
Disseminated fusariosis during acute myelogenous leukemia induction treatment. ( 24999512 )
2014
49
Disseminated Fusarium infection in a patient with acute lymphoblastic leukemia: A case report and review of the literature. ( 24396442 )
2014
50
Disseminated fusariosis secondary to neuroblastoma with fatal outcome. ( 23813153 )
2013

Variations for Fusariosis

Expression for Fusariosis

Search GEO for disease gene expression data for Fusariosis.

Pathways for Fusariosis

Pathways related to Fusariosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.93 IFNG POLR2A

GO Terms for Fusariosis

Sources for Fusariosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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