MCID: FSR001
MIFTS: 38

Fusariosis

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Fusariosis

MalaCards integrated aliases for Fusariosis:

Name: Fusariosis 12 58 43 15 17 71
Fusarium Infection 58

Characteristics:

Orphanet epidemiological data:

58
fusariosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050289
MeSH 43 D060585
ICD10 via Orphanet 33 B48.7
UMLS via Orphanet 72 C0276758
Orphanet 58 ORPHA228119
UMLS 71 C0276758

Summaries for Fusariosis

Disease Ontology : 12 An opportunistic mycosis that involves localized or hematogenously disseminated fungal infection by Fusarium solani or Fusarium oxysporum. Skin lesions are seen in neutropenic patients, and indolent cellulitis or soft-tissue necrosis occur in immunocompromised patients at the site of trauma.

MalaCards based summary : Fusariosis, also known as fusarium infection, is related to dermatomycosis and mucormycosis. An important gene associated with Fusariosis is POLR2B (RNA Polymerase II Subunit B), and among its related pathways/superpathways are mRNA Splicing - Minor Pathway and Transcriptional regulation of pluripotent stem cells. The drugs Voriconazole and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, myeloid and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Fusariosis is an infection seen in neutropenic patients, and is a significant opportunistic pathogen in... more...

Related Diseases for Fusariosis

Diseases related to Fusariosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 dermatomycosis 30.3 TEF POLR2B
2 mucormycosis 30.0 CYP51A1 CSF3
3 invasive aspergillosis 29.9 CYP51A1 CSF3
4 tinea pedis 29.7 POLR2B CYP51A1
5 opportunistic mycosis 29.2 CYP51A1 CSF3
6 neutropenia 10.7
7 lymphocytic leukemia 10.6
8 leukemia, acute lymphoblastic 10.6
9 aspergillosis 10.5
10 leukemia, acute myeloid 10.4
11 acute leukemia 10.4
12 myeloid leukemia 10.4
13 endophthalmitis 10.3
14 keratitis, hereditary 10.3
15 aplastic anemia 10.2
16 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.2
17 ecthyma 10.2
18 homologous wasting disease 10.2
19 scedosporiosis 10.2
20 cholesterol ester storage disease 10.2 LIPM LIPJ
21 lysosomal and lipase deficiency 10.1 LIPM LIPJ
22 noonan syndrome 8 10.1 POLR2B POLR2A
23 graft-versus-host disease 10.1
24 deficiency anemia 10.1
25 leukemia 10.1
26 pancytopenia 10.1
27 diarrhea 10.1
28 candidiasis 10.1
29 cellulitis 10.1
30 septic arthritis 10.1
31 noonan syndrome 4 10.0 POLR2B POLR2A
32 paronychia 10.0
33 maxillary sinusitis 10.0
34 lysosomal acid lipase deficiency 10.0 LIPM LIPJ
35 myositis 9.9
36 pulmonary hypertension, primary, 1 9.9
37 immune deficiency disease 9.9
38 lambert syndrome 9.9
39 mycosis fungoides 9.9
40 myeloma, multiple 9.9
41 yemenite deaf-blind hypopigmentation syndrome 9.9
42 leukemia, acute lymphoblastic 3 9.9
43 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.9
44 mantle cell lymphoma 9.9
45 lymphoma 9.9
46 osteomyelitis 9.9
47 pleurisy 9.9
48 endocarditis 9.9
49 meningoencephalitis 9.9
50 disseminated intravascular coagulation 9.9

Graphical network of the top 20 diseases related to Fusariosis:



Diseases related to Fusariosis

Symptoms & Phenotypes for Fusariosis

GenomeRNAi Phenotypes related to Fusariosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.61 NME5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.61 NME5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.61 LIPM NME5 POLR2B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.61 NME5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.61 NME5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.61 POLR2B
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.61 LIPM
8 Reduced mammosphere formation GR00396-S 9.02 CSF3 CYP51A1 EEF2 POLR2A POLR2B

Drugs & Therapeutics for Fusariosis

Drugs for Fusariosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Voriconazole Approved Phase 2 137234-62-9 71616
2
Posaconazole Approved, Investigational, Vet_approved 171228-49-2 147912
3
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
4
Caspofungin Approved 179463-17-3, 162808-62-0 468682 2826718
5 Antiparasitic Agents
6 Antiprotozoal Agents
7 Cytochrome P-450 CYP3A Inhibitors
8 Cytochrome P-450 Enzyme Inhibitors
9 Antifungal Agents
10 Hormone Antagonists
11 Steroid Synthesis Inhibitors
12 Anti-Infective Agents
13 Hormones
14 Cytochrome P-450 CYP2C9 Inhibitors
15 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PIVOTAL: Pharmacological Individualisation of VOriconazole Therapy for AntifungaL Treatment Suspended NCT01887457 Phase 2 VFEND
2 Fusariosis in Solid-Organ Transplant Recipients Completed NCT00518778
3 Multicenter Study About Fusarium Keratitits in Spain 2012 to 2014 Completed NCT02984904
4 Evaluation of the Efficacy of Anti-mold Azole Prophylaxis in High-risk Hematologic Patients With Baseline Superficial Skin Lesions Positive for Fusarium Spp Completed NCT02714504 Voriconazole or posaconazole
5 Fungal Contamination of a Hospital Water System With Fusarium App.: Prospective Environmental and Medical Surveillance During a Construction Period Completed NCT02859831
6 Empirical Antifungal Treatment in Neutropenic Patients Stratified by Risk: Prospective Validation of an Algorithm Based on the D-index Terminated NCT00982540 caspofungin as preemptive antifungal therapy

Search NIH Clinical Center for Fusariosis

Cochrane evidence based reviews: fusariosis

Genetic Tests for Fusariosis

Anatomical Context for Fusariosis

MalaCards organs/tissues related to Fusariosis:

40
Skin, Myeloid, Bone, Bone Marrow, Testes, Lung, Colon

Publications for Fusariosis

Articles related to Fusariosis:

(show top 50) (show all 601)
# Title Authors PMID Year
1
Cutaneous fusariosis caused by Fusarium lichenicola in a child with hyper-immunoglobulin E syndrome. 61
31829468 2019
2
Fosmanogepix (APX001) is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. 61
31818813 2019
3
Fusarium spp.-An Emerging Pathogen in Chronic Diabetic Ulcer: Case Report and Review of the Literature. 61
31722577 2019
4
Comparative in vitro pharmacodynamic analysis of isavuconazole, voriconazole, and posaconazole against clinical isolates of aspergillosis, mucormycosis, fusariosis, and phaeohyphomycosis. 61
31427139 2019
5
Disseminated Fusariosis in a Patient With Acute Myeloid Leukemia: A Case Report. 61
31788380 2019
6
Epidemiological aspects and characterization of the resistance profile of Fusarium spp. in patients with invasive fusariosis. 61
31419209 2019
7
Fusarium spp. in Loggerhead Sea Turtles (Caretta caretta): From Colonization to Infection. 61
31662046 2019
8
The emergence of zoonotic Fusarium oxysporum infection in captive-reared fingerlings of golden mahseer, Tor putitora (Hamilton, 1822) from the central Himalayan region of India. 61
31539213 2019
9
Assessment of Fusarium Infection and Mycotoxin Contamination of Wheat Kernels and Flour Using Hyperspectral Imaging. 61
31546581 2019
10
Acute acalculous cholecystitis due to Fusarium species and review of the literature on fungal cholecystitis. 61
31166627 2019
11
Fusarium Solani Infection Following Burn Injury: A Case Report. 61
31620346 2019
12
A multi-year survey of mycotoxins and ergosterol in Canadian oats. 61
31512221 2019
13
Long-term survival after cord blood transplantation for acute myeloid leukemia complicated with disseminated fusariosis. 61
31570321 2019
14
Fungemia due to Fusarium solani under low-dose liposomal amphotericin B in a patient after cord blood transplantation. 61
30910505 2019
15
Changes in Protein Composition in the Grain and Malt after Fusarium Infection Dependently of Wheat Resistance. 61
31357544 2019
16
Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia. 61
30900813 2019
17
Performance of 1,3-beta-D-glucan in the diagnosis and monitoring of invasive fusariosis. 61
31025423 2019
18
A retrospective cohort of invasive fusariosis in the era of antimould prophylaxis. 61
31231772 2019
19
Successful treatment of disseminated fusariosis in a patient with acute lymphoblastic leukemia: A case report and literature review. 61
31261588 2019
20
Selecting lipopeptide-producing, Fusarium-suppressing Bacillus spp.: Metabolomic and genomic probing of Bacillus velezensis NWUMFkBS10.5. 61
30358165 2019
21
Fusarium species intramedullary spinal cord fungus ball: case report. 61
31075770 2019
22
Unraveling the ecology and epidemiology of an emerging fungal disease, sea turtle egg fusariosis (STEF). 61
31095638 2019
23
Outcomes of patients with invasive fusariosis who undergo further immunosuppressive treatments, is there a role for secondary prophylaxis? 61
30720902 2019
24
Lipopeptide mediated biocontrol activity of endophytic Bacillus subtilis against fungal phytopathogens. 61
30940070 2019
25
Influence of Fusarium avenaceum infections on barley malt: Monitoring changes in the albumin fraction of barley during the malting process. 61
30616200 2019
26
Effects of intratracheal Fusarium solani inoculation in immunocompetent mice. 61
30660735 2019
27
Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station. 61
30944876 2019
28
Disseminated fusariosis with ecthyma gangrenosum-like lesions in a refractory acute myeloid leukemia patient. 61
31049455 2019
29
Endobronchial fusariosis in a child following bilateral lung transplant. 61
30723665 2019
30
Fusariosis in a Captive South American Sea Lion (Otaria flavescens): A Case Report. 61
29761326 2019
31
Molecular Characterization and Antifungal Susceptibility of Clinical Fusarium Species From Brazil. 61
31024507 2019
32
Fusarium infection-induced partial failure of free anterolateral thigh musculocutaneous flap: Case report. 61
31007923 2019
33
Multiresistant Fusarium Pathogens on Plants and Humans: Solutions in (from) the Antifungal Pipeline? 61
31819555 2019
34
Virus-Induced Gene Silencing (VIGS) for Functional Characterization of Disease Resistance Genes in Barley Seedlings. 61
30460561 2019
35
Retrospective evaluation of in vitro effect of gentamicin B1 against Fusarium species. 61
30315352 2018
36
Infections Caused by Fusarium Species in Pediatric Cancer Patients and Review of Published Literature. 61
29564632 2018
37
Toxic effects of the fungicide tebuconazole on the root system of fusarium-infected wheat plants. 61
30286405 2018
38
Rare mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in San Diego, CA: the role of antifungal combination therapy. 61
30099056 2018
39
Determination of total phenolic content, antioxidant activity and antifungal effects of Thymus vulgaris, Trachyspermum ammi and Trigonella foenum-graecum extracts on growth of Fusarium solani. 61
30511619 2018
40
Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient With Acute Lymphoblastic Leukemia. 61
29438132 2018
41
Invasive mould disease in haematologic patients: comparison between fusariosis and aspergillosis. 61
29787890 2018
42
Lipopeptides produced by Bacillus subtilis as new biocontrol products against fusariosis in ornamental plants. 61
28528498 2018
43
Lack of correlation of ECV and outcome in an in vivo murine model of systemic fusariosis. 61
30201117 2018
44
Tackling maize fusariosis: in search of Fusarium graminearum biosuppressors. 61
29934785 2018
45
Disseminated fusariosis with cutaneous involvement in hematologic malignancies: report of six cases with high mortality rate. 61
30156626 2018
46
Redox imbalance contributed differently to membrane damage of cucumber leaves under water stress and Fusarium infection. 61
30080601 2018
47
Integrating transcriptomic techniques and k-means clustering in metabolomics to identify markers of abiotic and biotic stress in Medicago truncatula. 61
30830458 2018
48
Genetic insights into underground responses to Fusarium graminearum infection in wheat. 61
30177750 2018
49
[Successful treatment of disseminated fusariosis in a febrile neutropenic patient with combined antifungal therapy of voriconazol plus amphotericin B deoxycholate]. 61
30534934 2018
50
Quantitative PCR (qPCR) Detection of Mucorales DNA in Bronchoalveolar Lavage Fluid To Diagnose Pulmonary Mucormycosis. 61
29875192 2018

Variations for Fusariosis

Expression for Fusariosis

Search GEO for disease gene expression data for Fusariosis.

Pathways for Fusariosis

Pathways related to Fusariosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.98 POLR2B POLR2A
2
Show member pathways
10.85 POLR2B POLR2A
3 10.42 POLR2B POLR2A
4 10.02 POLR2B POLR2A

GO Terms for Fusariosis

Cellular components related to Fusariosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II, core complex GO:0005665 8.62 POLR2B POLR2A

Biological processes related to Fusariosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA metabolic process GO:0016070 9.16 POLR2B POLR2A
2 7-methylguanosine mRNA capping GO:0006370 8.96 POLR2B POLR2A
3 positive regulation of viral transcription GO:0050434 8.62 POLR2B POLR2A

Molecular functions related to Fusariosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-directed 5'-3' RNA polymerase activity GO:0003899 9.16 POLR2B POLR2A
2 hydrolase activity, acting on ester bonds GO:0016788 8.96 LIPM LIPJ
3 RNA polymerase II activity GO:0001055 8.62 POLR2B POLR2A

Sources for Fusariosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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