Aliases & Classifications for Gait Apraxia

MalaCards integrated aliases for Gait Apraxia:

Name: Gait Apraxia 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4260
MeSH 44 D020235
SNOMED-CT 67 30767006
UMLS 70 C1510417

Summaries for Gait Apraxia

MalaCards based summary : Gait Apraxia is related to apraxia and hydrocephalus, and has symptoms including waddling gait, gait ataxia and gait dyspraxia. An important gene associated with Gait Apraxia is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Regulation of nuclear SMAD2/3 signaling. The drugs Vitamin D and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include pineal, and related phenotypes are Decreased TP53 mRNA expression and Decreased TP53 mRNA expression

Related Diseases for Gait Apraxia

Diseases related to Gait Apraxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 apraxia 10.6
2 hydrocephalus 10.3
3 mecp2 disorders 10.2 MECP2 FOXG1
4 developmental and epileptic encephalopathy 14 10.1 MECP2 CDKL5
5 encephalopathy due to defective mitochondrial and peroxisomal fission 1 10.1 MECP2 CDKL5
6 parkinsonism 10.1
7 normal pressure hydrocephalus 10.1
8 spasticity 10.1
9 echolalia 10.1 MECP2 GRN
10 christianson syndrome 10.0 MECP2 FOXG1 CDKL5
11 neonatal period electroclinical syndrome 10.0 MECP2 CDKL5
12 infancy electroclinical syndrome 10.0 MECP2 FOXG1 CDKL5
13 bruxism 10.0 MECP2 FOXG1 CDKL5
14 mowat-wilson syndrome 10.0 MECP2 FOXG1 CDKL5
15 pitt-hopkins syndrome 10.0 MECP2 FOXG1 CDKL5
16 congenital nervous system abnormality 10.0 MECP2 FOXG1 CDKL5
17 lennox-gastaut syndrome 10.0 MECP2 FOXG1 CDKL5
18 dravet syndrome 10.0 MECP2 FOXG1 CDKL5
19 multiple sclerosis 9.9
20 ataxia and polyneuropathy, adult-onset 9.9
21 neurogenic bladder 9.9
22 hyperparathyroidism 9.9
23 communicating hydrocephalus 9.9
24 central nervous system lymphoma 9.9
25 cerebrovascular disease 9.9
26 binswanger's disease 9.9
27 cluttering 9.9
28 primary central nervous system lymphoma 9.9
29 pure autonomic failure 9.9
30 cerebral atrophy 9.9
31 encephalopathy 9.9
32 headache 9.9
33 west syndrome 9.9 MECP2 FOXG1 CDKL5
34 specific developmental disorder 9.9 MECP2 GRN CDKL5
35 immunodeficiency-centromeric instability-facial anomalies syndrome 9.8 MECP2 CXXC1
36 pervasive developmental disorder 9.8 MECP2 FOXG1 CXXC1 CDKL5
37 early infantile epileptic encephalopathy 9.8 MECP2 FOXG1 CDKL5
38 gene duplication disease 9.7 SIN3A MECP2 FOXG1 CDKL5
39 lubs x-linked mental retardation syndrome 9.7 SIN3A MECP2 FOXG1 CDKL5
40 rett syndrome 9.7 SIN3A MECP2 FOXG1 CDKL5
41 autosomal dominant non-syndromic intellectual disability 9.6 MECP2 FOXG1 CDR2
42 microcephaly 9.3 SIN3A MECP2 FOXG1 CXXC1 CDKL5
43 disease of mental health 8.5 SIN3A RD3 MECP2 GRN FOXG1 CXXC1

Graphical network of the top 20 diseases related to Gait Apraxia:



Diseases related to Gait Apraxia

Symptoms & Phenotypes for Gait Apraxia

UMLS symptoms related to Gait Apraxia:


waddling gait; gait ataxia; gait dyspraxia

GenomeRNAi Phenotypes related to Gait Apraxia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.8 SIN3A
2 Decreased TP53 mRNA expression GR00389-S-6 8.8 CXXC1 SIN3A

MGI Mouse Phenotypes related to Gait Apraxia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 CDKL5 FOXG1 GRN MECP2 NOVA1 RD3

Drugs & Therapeutics for Gait Apraxia

Drugs for Gait Apraxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
2 Trace Elements
3 Nutrients
4 Vitamins
5 Calciferol
6 Micronutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Etude de l'adhérence et Des Effets Des Ateliers "équilibre Siel Bleu" Sur la Marche, la Cognition, l'Autonomie et l'indépendance Des Sujets Atteints d'Une Maladie d'Alzheimer, et Sur le Fardeau de l'Aidant Principal Unknown status NCT01314638
2 Maladie d'Alzheimer et Maladies apparentées : Caractérisation Des Anomalies Cognitivo-motrices, et Des Effets Des médicaments Anti-démence et de la Vitamine D à Partir de la Mise en Place d'Une Base de données au CMRR du CHU d'Angers Unknown status NCT01315704 Drug intervention
3 Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia Unknown status NCT00494689
4 Maladie d'Alzheimer et Troubles Locomoteurs : Caracterisation Des Anomalies Temporelles de la Marche et Etude Des Correlats Anatomo-cognitifs Completed NCT01315717
5 Comparisons of gaIt aNalyses pERformance Between the Gaitrite walkwaYs Completed NCT04557592
6 Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study Recruiting NCT03020381

Search NIH Clinical Center for Gait Apraxia

Cochrane evidence based reviews: gait apraxia

Genetic Tests for Gait Apraxia

Anatomical Context for Gait Apraxia

MalaCards organs/tissues related to Gait Apraxia:

40
Pineal

Publications for Gait Apraxia

Articles related to Gait Apraxia:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus. 61
33242372 2020
2
Longitudinal magnetic resonance findings in delayed posthypoxic leukoencephalopathy. 61
33100569 2020
3
Clinical Reasoning: A 75-Year-Old Man With Dementia, Incontinence, and Gait Dysfunction. 61
32839680 2020
4
Idiopathic Normal Pressure Hydrocephalus With Stuttering: Report of Two Cases and Review of the Literature. 61
31805405 2020
5
The effects of cerebrospinal fluid tap-test on idiopathic normal pressure hydrocephalus: an inertial sensors based assessment. 61
31948485 2020
6
Wernicke Encephalopathy-Clinical Pearls. 61
31171116 2019
7
Normal-pressure hydrocephalus: A critical review. 61
31285787 2019
8
New insights in radiation-induced leukoencephalopathy: a prospective cross-sectional study. 61
29982900 2018
9
Gait in normal pressure hydrocephalus: characteristics and effects of the CSF tap test. 61
29898079 2018
10
Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis. 61
26852960 2016
11
Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer's disease. 61
27332069 2016
12
Cognitive training modifies frequency EEG bands and neuropsychological measures in Rett syndrome. 61
26859707 2016
13
Behavioral variant frontotemporal dementia with dominant gait disturbances - case report. 61
27288678 2016
14
Performance of the fixed pressure valve with antisiphon device SPHERA® in the treatment of normal pressure hydrocephalus and prevention of overdrainage. 61
26602193 2016
15
Evidences in the treatment of idiopathic normal pressure hydrocephalus. 61
26248249 2015
16
Questioning vitamin D status of elderly fallers and nonfallers: a meta-analysis to address a 'forgotten step'. 61
24697944 2015
17
Supplementary Motor Complex and Disturbed Motor Control - a Retrospective Clinical and Lesion Analysis of Patients after Anterior Cerebral Artery Stroke. 61
26528234 2015
18
Apraxias in neurodegenerative dementias. 61
25722511 2015
19
Fear of falling and gait variability in older adults: a systematic review and meta-analysis. 61
25230892 2015
20
Anti-dementia drugs-related changes in gait performance while single and dual tasking in patients with Alzheimer disease: a meta-analysis. 61
26159199 2015
21
Changes in gait variability with anti-dementia drugs: a systematic review and meta-analysis. 61
24806974 2014
22
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. 61
24586232 2014
23
Endoscopic third ventriculostomy for hydrocephalus due to unruptured pineal AVM: case report and review of the literature. 61
23427035 2013
24
Clinical symptoms and risk factors in cerebral microangiopathy patients. 61
23393549 2013
25
A second case of isolated gait apraxia from an acute unilateral parasagittal lesion. 61
22560156 2012
26
Frontal lobe ataxia. 61
21827922 2012
27
A case of diabetes mellitus associated with Rett syndrome. 61
22570976 2012
28
Endovascular treatment of cervical giant perimedullary arteriovenous fistulas. 61
21796011 2012
29
[Vascular or "lower body Parkinsonism": rise and fall of a diagnosis]. 61
22611616 2011
30
Isolated gait apraxia from an acute unilateral parasagittal lesion. 61
21880413 2011
31
Gait apraxia. 61
20429324 2010
32
Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease. 61
19683260 2009
33
Vitamin D-related changes in physical performance: a systematic review. 61
19924350 2009
34
Gait apraxia in multiple sclerosis. 61
19831123 2009
35
Prediction of survival in Alzheimer's disease--the LASER-AD longitudinal study. 61
19189277 2009
36
Higher level gait disorders in subcortical chronic vascular encephalopathy: a single photon emission computed tomography study. 61
19297373 2009
37
Paleoneurology: neurodegenerative diseases are age-related diseases of specific brain regions recently developed by Homo sapiens. 61
18703290 2008
38
Stage-independent and stage-specific phenotypic differences between vascular dementia and Alzheimer's Disease. 61
19052451 2008
39
[Rett syndrome: 50 years' history of a still not well known condition]. 61
18422079 2007
40
Gait apraxia: further clues to localization. 61
17622719 2007
41
Gait and dementia: moving beyond the notion of gait apraxia. 61
17510733 2007
42
[Idiopathic normal pressure hydrocephalus]. 61
16836199 2006
43
Normal pressure hydrocephalus in a patient with myotonic dystrophy: case report with a 10-year follow-up. 61
16575302 2006
44
The syndrome of hydrocephalus in young and middle-aged adults (SHYMA). 61
15978182 2005
45
Apraxia in movement disorders. 61
15930045 2005
46
Restraint free care in older adults with dementia. 61
16077257 2005
47
Falls associated with dementia: how can you tell? 61
15824725 2005
48
[Apraxia of gait: an acquired sequela with a poor prognosis]. 61
15782358 2005
49
Walking difficulties in patients with Alzheimer's disease might originate from gait apraxia. 61
14742586 2004
50
A new classification of higher level gait disorders in patients with cerebral multi-infarct states. 61
12720609 2003

Variations for Gait Apraxia

Expression for Gait Apraxia

Search GEO for disease gene expression data for Gait Apraxia.

Pathways for Gait Apraxia

Pathways related to Gait Apraxia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 SIN3A MECP2 CXXC1
2 11.14 SIN3A FOXG1
3 10.95 SIN3A MECP2
4
Show member pathways
10.67 SIN3A MECP2

GO Terms for Gait Apraxia

Biological processes related to Gait Apraxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.13 NOVA1 MECP2 FOXG1
2 positive regulation of G2/M transition of mitotic cell cycle GO:0010971 8.62 SIN3A MECP2

Sources for Gait Apraxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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