Aliases & Classifications for Gait Apraxia

MalaCards integrated aliases for Gait Apraxia:

Name: Gait Apraxia 12 29 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4260
MeSH 44 D020235
SNOMED-CT 68 30767006
UMLS 73 C1510417

Summaries for Gait Apraxia

MalaCards based summary : Gait Apraxia is related to dementia and alzheimer disease, and has symptoms including waddling gait, gait ataxia and gait dyspraxia. An important gene associated with Gait Apraxia is GRN (Granulin Precursor), and among its related pathways/superpathways are Neuroscience and A-beta Signaling Pathways. The drugs Vitamin D and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include brain and bone, and related phenotypes are nervous system and no phenotypic analysis

Related Diseases for Gait Apraxia

Diseases related to Gait Apraxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 dementia 28.0 APOE APP GRN PSEN1
2 alzheimer disease 27.1 APOE APP GRN PSEN1
3 apraxia 10.5
4 phonagnosia 10.4 GRN PSEN1
5 associative agnosia 10.4 GRN PSEN1
6 progressive non-fluent aphasia 10.3 GRN PSEN1
7 behavioral variant of frontotemporal dementia 10.3 GRN PSEN1
8 writing disorder 10.3 GRN PSEN1
9 prosopagnosia 10.3 GRN PSEN1
10 bruxism 10.2 CDKL5 MECP2
11 visual agnosia 10.2 GRN PSEN1
12 paraphilia disorder 10.2 CBS GRN
13 epileptic encephalopathy, early infantile, 9 10.1 CDKL5 MECP2
14 hydrocephalus 10.1
15 hydrocephalus, normal-pressure 10.0
16 early-onset, autosomal dominant alzheimer disease 9.9 APP PSEN1
17 echolalia 9.9 CBS GRN PSEN1
18 kluver-bucy syndrome 9.9 APP PSEN1
19 agraphia 9.9 CBS GRN PSEN1
20 ideomotor apraxia 9.9 CBS GRN PSEN1
21 nominal aphasia 9.9 CBS GRN PSEN1
22 basal ganglia disease 9.9 CBS GRN PSEN1
23 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 9.8 CBS GRN PSEN1
24 multiple sclerosis 9.8
25 hyperparathyroidism 9.8
26 communicating hydrocephalus 9.8
27 headache 9.8
28 early-onset familial alzheimer disease 9.8 APP PSEN1
29 alzheimer disease 4 9.7 APOE PSEN1
30 meningoencephalitis 9.7 APP MECP2
31 alexia 9.7 APOE PSEN1
32 senile plaque formation 9.7 APOE APP
33 specific developmental disorder 9.5 CDKL5 GRN MECP2 PSEN1
34 binswanger's disease 9.5 APOE APP
35 semantic dementia 9.5 APOE GRN PSEN1
36 hemorrhage, intracerebral 9.4 APOE APP
37 gallbladder disease 9.1 APOE MECP2
38 familial idiopathic basal ganglia calcification 9.1 APOE APP PSEN1
39 alzheimer disease 2 9.1 APOE APP PSEN1
40 cerebral amyloid angiopathy, cst3-related 9.1 APOE APP PSEN1
41 cerebrovascular disease 9.0 APOE APP CBS
42 vascular dementia 9.0 APOE APP PSEN1
43 amyloidosis 9.0 APOE APP PSEN1
44 aphasia 8.7 APOE APP GRN PSEN1
45 pick disease of brain 8.7 APOE APP GRN PSEN1
46 central nervous system disease 8.7 APOE APP GRN PSEN1
47 nervous system disease 8.7 APOE APP GRN PSEN1
48 frontotemporal dementia 8.7 APOE APP GRN PSEN1
49 speech and communication disorders 8.5 APOE CBS GRN MECP2 PSEN1
50 disease of mental health 8.3 APOE APP GRN MECP2 PSEN1

Graphical network of the top 20 diseases related to Gait Apraxia:



Diseases related to Gait Apraxia

Symptoms & Phenotypes for Gait Apraxia

UMLS symptoms related to Gait Apraxia:


waddling gait, gait ataxia, gait dyspraxia

MGI Mouse Phenotypes related to Gait Apraxia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.7 SLC25A20 APOE APP CDKL5 GRN MECP2
2 no phenotypic analysis MP:0003012 9.35 APOE APP CDKL5 GRN MECP2
3 vision/eye MP:0005391 9.02 PSEN1 APOE CDKL5 GRN MECP2

Drugs & Therapeutics for Gait Apraxia

Drugs for Gait Apraxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
2
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
3 Micronutrients
4 Trace Elements
5 Ergocalciferols
6 Vitamins
7 Bone Density Conservation Agents
8 Vitamin D2 Nutraceutical
9 Calciferol Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy, Safety, and Tolerability of Sarizotan in Rett Syndrome With Respiratory Symptoms Recruiting NCT02790034 Phase 2, Phase 3 Sarizotan;Placebo
2 Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia Unknown status NCT00494689
3 Study of Adherence and Effects of Balance Exercices (SIEL BLEU Associatio) Unknown status NCT01314638
4 Alzheimer's Disease and Related Disorders Unknown status NCT01315704 Drug intervention
5 Gait and Alzheimer Interaction Tracking (GAIT) Study Completed NCT01315717
6 Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study Recruiting NCT03020381

Search NIH Clinical Center for Gait Apraxia

Cochrane evidence based reviews: gait apraxia

Genetic Tests for Gait Apraxia

Genetic tests related to Gait Apraxia:

# Genetic test Affiliating Genes
1 Gait Apraxia 29

Anatomical Context for Gait Apraxia

MalaCards organs/tissues related to Gait Apraxia:

41
Brain, Bone

Publications for Gait Apraxia

Articles related to Gait Apraxia:

(show all 18)
# Title Authors Year
1
Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer's disease. ( 27332069 )
2016
2
A second case of isolated gait apraxia from an acute unilateral parasagittal lesion. ( 22560156 )
2012
3
Isolated gait apraxia from an acute unilateral parasagittal lesion. ( 21880413 )
2011
4
Gait apraxia. ( 20429324 )
2010
5
Gait apraxia in multiple sclerosis. ( 19831123 )
2009
6
Gait and dementia: moving beyond the notion of gait apraxia. ( 17510733 )
2007
7
Gait apraxia: further clues to localization. ( 17622719 )
2007
8
Walking difficulties in patients with Alzheimer's disease might originate from gait apraxia. ( 14742586 )
2004
9
Gait apraxia after bilateral supplementary motor area lesion. ( 11784830 )
2002
10
Frontal gait apraxia. Pathophysiological mechanisms and rehabilitation. ( 11347240 )
2001
11
A SPECT study of patients with gait apraxia without evidence of frontal lobe dysfunction. ( 9614780 )
1998
12
Gait apraxia and headache. ( 8370100 )
1993
13
L-threo-3,4-dihydroxyphenylserine treatment for gait apraxia in parkinsonian patients. ( 2511378 )
1989
14
Risk factors for the syndrome of ventricular enlargement with gait apraxia (idiopathic normal pressure hydrocephalus): a case-control study. ( 2769278 )
1989
15
Gait apraxia in normal-pressure hydrocephalus: patterns of movement and muscle activation. ( 3969202 )
1985
16
Parkinsonism, gait apraxia and dementia associated with intracranial calcifications. A case report. ( 6845088 )
1983
17
Gait apraxia in communicating hydrocephalus. ( 7241157 )
1981
18
Intracranial calcification in hyperparathyroidism associated with gait apraxia and parkinsonism. ( 7191528 )
1980

Variations for Gait Apraxia

Expression for Gait Apraxia

Search GEO for disease gene expression data for Gait Apraxia.

Pathways for Gait Apraxia

Pathways related to Gait Apraxia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 APOE APP MECP2 PSEN1
2 11.11 APP PSEN1
4 10.76 APOE APP
5 10.52 APP PSEN1
6 10.45 APOE APP PSEN1

GO Terms for Gait Apraxia

Cellular components related to Gait Apraxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuromuscular junction GO:0031594 9.26 APP PSEN1
2 dendritic shaft GO:0043198 9.16 APP PSEN1
3 smooth endoplasmic reticulum GO:0005790 8.96 APP PSEN1
4 ciliary rootlet GO:0035253 8.62 APP PSEN1

Biological processes related to Gait Apraxia according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.77 APOE APP MECP2
2 negative regulation of gene expression GO:0010629 9.77 APOE APP MECP2
3 cellular protein metabolic process GO:0044267 9.74 APOE APP PSEN1
4 negative regulation of neuron apoptotic process GO:0043524 9.7 APOE MECP2 PSEN1
5 response to oxidative stress GO:0006979 9.69 APOE APP PSEN1
6 mitochondrial transport GO:0006839 9.65 PSEN1 SLC25A20
7 learning or memory GO:0007611 9.64 APP PSEN1
8 adult locomotory behavior GO:0008344 9.64 APP MECP2
9 regulation of synaptic plasticity GO:0048167 9.63 MECP2 PSEN1
10 visual learning GO:0008542 9.63 APP MECP2
11 synapse organization GO:0050808 9.62 APP PSEN1
12 negative regulation of blood vessel endothelial cell migration GO:0043537 9.62 APOE MECP2
13 neuron apoptotic process GO:0051402 9.61 APP PSEN1
14 long-term memory GO:0007616 9.61 APOE MECP2
15 positive regulation of phosphorylation GO:0042327 9.58 APP PSEN1
16 dendrite development GO:0016358 9.58 APP MECP2
17 cellular response to amyloid-beta GO:1904646 9.56 APP PSEN1
18 positive regulation of G2/M transition of mitotic cell cycle GO:0010971 9.55 APP MECP2
19 regulation of protein binding GO:0043393 9.54 APP PSEN1
20 amyloid precursor protein metabolic process GO:0042982 9.49 APOE PSEN1
21 negative regulation of long-term synaptic potentiation GO:1900272 9.48 APOE APP
22 astrocyte activation GO:0048143 9.46 APP PSEN1
23 modulation of age-related behavioral decline GO:0090647 9.43 APP PSEN1
24 neuron projection maintenance GO:1990535 9.4 APP PSEN1
25 regulation of epidermal growth factor-activated receptor activity GO:0007176 9.37 APP PSEN1
26 astrocyte activation involved in immune response GO:0002265 9.32 APP PSEN1
27 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.26 APP PSEN1
28 smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 9.16 APP PSEN1
29 positive regulation of dendritic spine development GO:0060999 9.13 APOE CDKL5 PSEN1
30 positive regulation of amyloid fibril formation GO:1905908 8.8 APOE APP PSEN1

Sources for Gait Apraxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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