Aliases & Classifications for Galactorrhea

MalaCards integrated aliases for Galactorrhea:

Name: Galactorrhea 57 76 37 29 73
Galactorrhea Not Associated with Childbirth 73
Galactorrhea Associated with Childbirth 73

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
galactorrhea:
Inheritance autosomal recessive inheritance


External Ids:

OMIM 57 230300
MedGen 42 C3665358
KEGG 37 H01607
SNOMED-CT via HPO 69 258211005 287085006 42030000

Summaries for Galactorrhea

MalaCards based summary : Galactorrhea, also known as galactorrhea not associated with childbirth, is related to pituitary adenoma, prolactin-secreting and hyperprolactinemia, and has symptoms including nipple discharge, signs and symptoms in breast and female endocrine problem. An important gene associated with Galactorrhea is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and ErbB4 Pathway. The drugs Zinc and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include breast, pituitary and hypothalamus, and related phenotypes are abnormality of the genitourinary system and abnormality of the thorax

Wikipedia : 76 Galactorrhea (also spelled galactorrhoea) (galacto- + -rrhea) or lactorrhea (lacto- + -rrhea) is the... more...

Description from OMIM: 230300

Related Diseases for Galactorrhea

Diseases related to Galactorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma, prolactin-secreting 30.3 DRD2 IGF1 PRL
2 hyperprolactinemia 30.1 DRD2 IGF1 PRL PRLR
3 chromophobe adenoma 29.8 PRL PRLR
4 prolactin producing pituitary tumor 29.7 DRD2 PRL
5 pituitary tumors 29.7 IGF1 PRL
6 empty sella syndrome 29.6 IGF1 PRL
7 hypopituitarism 29.3 IGF1 PRL
8 acromegaly 29.3 IGF1 PRL
9 mccune-albright syndrome 29.2 IGF1 PRL
10 craniopharyngioma 29.1 IGF1 PRL
11 obsessive-compulsive disorder 28.8 CYP2D6 DRD2 PRL
12 bipolar disorder 28.1 DRD2 IGF1 PRL
13 amenorrhea-galactorrhea syndrome 12.1
14 ahumada del castillo syndrome 11.4
15 galactorrhoea-hyperprolactinaemia 11.1
16 amenorrhea 10.4
17 endometriosis of uterus 10.3 PRL PRLR
18 schizophreniform disorder 10.2 DRD2 PRL
19 social phobia 10.2 DRD2 PRL
20 functioning pituitary adenoma 10.2 DRD2 PRL
21 peripartum cardiomyopathy 10.2 DRD2 PRL
22 migraine without aura 10.1 DRD2 PRL
23 cocaine abuse 10.1 DRD2 PRL
24 tardive dyskinesia 10.1 CYP2D6 DRD2
25 neuroleptic malignant syndrome 10.1 CYP2D6 DRD2
26 gastroparesis 10.0 CYP2D6 DRD2
27 gynecomastia 10.0
28 pituitary infarct 10.0 IGF1 PRL
29 alcohol abuse 10.0 DRD2 PRL
30 pseudohypoparathyroidism, type ia 10.0 IGF1 PRL
31 pituitary adenoma 1, multiple types 10.0 IGF1 PRL
32 schizoaffective disorder 9.9 DRD2 PRL
33 sheehan syndrome 9.9 IGF1 PRL
34 hypothyroidism 9.9
35 infertility 9.9
36 adenoma 9.9
37 mammographic density 9.9 IGF1 PRL
38 hyperpituitarism 9.9 IGF1 PRL
39 hypothyroidism, congenital, nongoitrous, 4 9.9 IGF1 PRL
40 central nervous system organ benign neoplasm 9.9 IGF1 PRL
41 endocrine organ benign neoplasm 9.9 IGF1 PRL
42 pituitary hormone deficiency, combined, 2 9.8 IGF1 PRL
43 substance dependence 9.8 CYP2D6 DRD2
44 fibrous dysplasia 9.8 IGF1 PRL
45 anovulation 9.8 IGF1 PRL
46 thyroid gland disease 9.8 IGF1 PRL
47 organ system benign neoplasm 9.8 IGF1 PRL
48 pituitary gland disease 9.8 IGF1 PRL
49 acanthosis nigricans 9.8 IGF1 PRL
50 diabetes mellitus, ketosis-prone 9.8

Graphical network of the top 20 diseases related to Galactorrhea:



Diseases related to Galactorrhea

Symptoms & Phenotypes for Galactorrhea

Symptoms via clinical synopsis from OMIM:

57
Thorax:
nonpuerperal galactorrhea

GU:
oligoovulation


Clinical features from OMIM:

230300

Human phenotypes related to Galactorrhea:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the genitourinary system 32 HP:0000119
2 abnormality of the thorax 32 HP:0000765
3 galactorrhea 32 HP:0100829

UMLS symptoms related to Galactorrhea:


nipple discharge, signs and symptoms in breast, female endocrine problem, discharge, nipple, female

MGI Mouse Phenotypes related to Galactorrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 DRD2 IGF1 PRL PRLR
2 integument MP:0010771 9.46 DRD2 IGF1 PRL PRLR
3 neoplasm MP:0002006 9.26 DRD2 IGF1 PRL PRLR
4 reproductive system MP:0005389 8.92 DRD2 IGF1 PRL PRLR

Drugs & Therapeutics for Galactorrhea

Drugs for Galactorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Not Applicable 7440-66-6 23994
2
Aripiprazole Approved, Investigational Not Applicable 129722-12-9 60795
3 Radiopharmaceuticals Not Applicable
4 Technetium Tc 99m Sestamibi Not Applicable
5 Antipsychotic Agents Not Applicable
6 Central Nervous System Depressants Not Applicable
7 Hormones Not Applicable
8 Psychotropic Drugs Not Applicable
9 Tranquilizing Agents Not Applicable
10 Quetiapine Fumarate 111974-72-2
11 Whey Protein Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Safety and Efficacy of Recombinant Human Prolactin Completed NCT00438490 Phase 2 Recombinant Human Prolactin
2 Molecular Breast Imaging in Patients With a History of Bloody Nipple Discharge Completed NCT00566280 Not Applicable
3 Double-Blind Placebo Controlled Study of Adjunctive Aripiprazole for Symptomatic Hyperprolactinemia In Premenopausal Women With Schizophrenia Completed NCT01338298 Not Applicable Aripiprazole;Placebo
4 Changes in Hyperprolactinemia Secondary to Antipsychotics After Switching to Quetiapine Completed NCT00952757
5 Hyperprolactinaemia Management in Reproductive Services at University Hospital of Coventry and Warwickshire Completed NCT03569787
6 Benefit of a Diagnostic MRI in Case of Pathological Nipple Discharge With Normal Mammography / Ultrasound Recruiting NCT02819362
7 Diagnostic Utility of MRI in Female Patients With Nipple Discharge: A Prospective Trial Recruiting NCT02818946 Not Applicable
8 Feasibility and Therapeutic Efficacy of Ductoscopic Papilloma Extraction in Patients With Pathologic Nipple Discharge Recruiting NCT01901562 Not Applicable
9 Prenatal Lactation-Focused Motivational Interviewing Recruiting NCT03033459 Not Applicable
10 Evaluation of A Partially Hydrolyzed in Improving FGIDs Symptoms Not yet recruiting NCT03390309 Not Applicable

Search NIH Clinical Center for Galactorrhea

Genetic Tests for Galactorrhea

Genetic tests related to Galactorrhea:

# Genetic test Affiliating Genes
1 Galactorrhea 29

Anatomical Context for Galactorrhea

MalaCards organs/tissues related to Galactorrhea:

41
Breast, Pituitary, Hypothalamus, Myeloid, Testes, Kidney, Brain

Publications for Galactorrhea

Articles related to Galactorrhea:

(show top 50) (show all 114)
# Title Authors Year
1
Hyperprolactinemic Galactorrhea as a Side Effect of Aripiprazole: An Adolescent Case (Aripiprazole-Related Hyperprolactinemic Galactorrhea). ( 29360652 )
2018
2
Galactorrhea with antidepressants: A case series. ( 29736080 )
2018
3
An Unusual Case of Galactorrhea With Normal Serum Prolactin. ( 28056542 )
2018
4
Delayed galactorrhea after discontinuation of risperidone in a schizophrenia patient. ( 28837941 )
2017
5
Galactorrhea Probably Related with Switching from Osmotic-release Oral System Methylphenidate (MPH) to Modified-release MPH: An Adolescent Case. ( 28783939 )
2017
6
An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient? ( 28791188 )
2017
7
Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine. ( 28449567 )
2017
8
Galactorrhea After Selective Serotonin Reuptake Inhibitor Use in an Adolescent Girl: A Case Report. ( 28383361 )
2017
9
Impact of macroprolactin on galactorrhea and the rate of patients possibly affected by macroprolactin. ( 29162783 )
2017
10
Paraneoplastic Galactorrhea in Childhood T-ALL: An Evaluation of Tumor-derived Prolactin. ( 27820136 )
2017
11
Esomeprazole induced galactorrhea: a novel side effect. ( 26661629 )
2016
12
Acute myeloid leukemia presenting as galactorrhea. ( 27695173 )
2016
13
Citalopram-Induced Galactorrhea in an Adolescent. ( 27438185 )
2016
14
Venlafaxine-Associated Euprolactinemic Galactorrhea and Hypersexuality: A Case Report and Review of the Literature. ( 27219091 )
2016
15
A case of galactorrhea during paroxetine treatment. ( 27284122 )
2016
16
A 33-Year-Old Man with Gynaecomastia and Galactorrhea as the First Symptoms of Graves Hyperthyroidism. ( 28044109 )
2016
17
An assessment of serum prolactin levels among infertile women with galactorrhea attending a gynecological clinic North-West Nigeria. ( 27397959 )
2016
18
Methemoglobinemia Caused by Topical Dapsone Gel; Renal Tubular Acidosis After Topiramate Administration; Diabetic Ketoacidosis Following Epidural Steroid Injection in a Nondiabetic Patient; Galactorrhea Associated with Bupropion Therapy; Telaprevir-Induced Acquired Perforating Dermatosis; Manic Episodes Associated with Tramadol Use. ( 26448655 )
2015
19
Galactorrhea in a Patient With Aquaporin-4 Antibody-positive Neuromyelitis Optica Spectrum Disorder: A Case Report and Review of the Literature. ( 26671741 )
2015
20
A 17-year-old female with secondary amenorrhea, galactorrhea, and headaches. ( 25547318 )
2015
21
Nonconvulsive Status Epilepticus in Elderly Patients Receiving SSRIs; Euglycemic Diabetic Ketoacidosis Associated with Canagliflozin Use in a Type 1 Diabetic Patient; Duloxetine-Induced Galactorrhea; Canagliflozin-Associated Severe Hypercalcemia and Hypernatremia; Vemurafenib-Induced Fanconi Syndrome. ( 26912914 )
2015
22
Sertraline Induced Galactorrhea. ( 28360706 )
2015
23
Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine. ( 26598592 )
2015
24
Duloxetine-related galactorrhea and restless legs syndrome: a case report. ( 24048395 )
2013
25
A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series. ( 24294485 )
2013
26
Burns, hypertrophic scar and galactorrhea. ( 23456048 )
2013
27
Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations. ( 24194758 )
2013
28
Index of suspicion. Case 1: abdominal pain, distension, hard stool, and diarrhea in an 11-year-old boy. Case 2: recurrent otitis media in a 4-year-old boy. Case 3: gynecomastia and galactorrhea in a 15-year-old boy. ( 23818086 )
2013
29
Prolactinoma presenting as unilateral galactorrhea in a man exposed to radioactivity from the Chernobyl accident: radiation-induced pituitary tumor? ( 21595669 )
2011
30
Marked mydriasis and neuritis nervi optici associated with galactorrhea following citalopram treatment: a case report and discussion. ( 21869891 )
2011
31
Euprolactinemic gynecomastia and galactorrhea with risperidone-fluvoxamine combination. ( 22506441 )
2011
32
Dose-dependent galactorrhea with quetiapine. ( 21267374 )
2010
33
Galactorrhea - side effect of risperidone in combination with depakine chrono in a patient with bipolar disorder. ( 20305608 )
2010
34
Galactorrhea with metoclopramide use in the neonatal unit. ( 19398999 )
2009
35
Pregnancy rate following bromocriptine treatment in infertile women with galactorrhea. ( 19253108 )
2009
36
Galactorrhea associated with juvenile systemic lupus erythematosus: a review of the role of prolactin. ( 19852783 )
2009
37
Galactorrhea and amenorrhea in burn patients. ( 18403124 )
2008
38
[Primary glucocorticoid resistance syndrome presenting as pseudo-precocious puberty and galactorrhea]. ( 19024330 )
2008
39
The prevalence of hyperprolactinemia and galactorrhea in patients with abnormal uterine bleeding. ( 18569035 )
2008
40
Visual vignette. Postherpetic neuralgia and galactorrhea. ( 18463051 )
2008
41
Cessation of galactorrhea in a chronic kidney disease patient with non-tumoral hyperprolactinemia after renal transplantation. ( 18472504 )
2008
42
[Irregular secretion of prolactin in infertile women with normoprolactinemic galactorrhea]. ( 17542255 )
2007
43
Hyperprolactinemia and galactorrhea induced by serotonin and norepinephrine reuptake inhibiting antidepressants. ( 17606668 )
2007
44
Galactorrhea complicating wound healing following reduction mammaplasty. ( 19338911 )
2006
45
Ziprasidone-induced galactorrhea: a case report. ( 15726024 )
2005
46
Galactorrhea during treatment with trimipramine. A case report. ( 16342006 )
2005
47
Olanzapine-induced hyperprolactinemia and galactorrhea reversed with addition of bromocriptine: a case report. ( 15705020 )
2005
48
A male infant with gynecomastia-galactorrhea. ( 16291370 )
2005
49
Hypopituitarism and amenorrhea-galactorrhea syndrome caused by thrombosis of both internal carotid artery and giant intrasellar aneurysm: case report. ( 15122453 )
2004
50
Postburn galactorrhea with refractory hypertrophic scars: role of obesity under scrutiny. ( 14610425 )
2003

Variations for Galactorrhea

Expression for Galactorrhea

Search GEO for disease gene expression data for Galactorrhea.

Pathways for Galactorrhea

Pathways related to Galactorrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.26 IGF1 PRL PRLR
2
Show member pathways
12.03 IGF1 PRL PRLR
3 11.49 IGF1 PRLR
4
Show member pathways
11.36 PRL PRLR
5 10.65 PRL PRLR
6
Show member pathways
10.24 PRL PRLR

GO Terms for Galactorrhea

Cellular components related to Galactorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRL PRLR

Biological processes related to Galactorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.26 IGF1 PRL
2 lactation GO:0007595 9.16 PRL PRLR
3 regulation of multicellular organism growth GO:0040014 8.96 IGF1 PRL
4 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 PRL PRLR

Molecular functions related to Galactorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 IGF1 PRL
2 drug binding GO:0008144 8.62 CYP2D6 DRD2

Sources for Galactorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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