MCID: GLC025
MIFTS: 20

Galactorrhoea-Hyperprolactinaemia

Categories: Rare diseases

Aliases & Classifications for Galactorrhoea-Hyperprolactinaemia

MalaCards integrated aliases for Galactorrhoea-Hyperprolactinaemia:

Name: Galactorrhoea-Hyperprolactinaemia 20 6
Galactorrhea-Hyperprolactinemia 20 71
Hyperprolactinaemia 20

Classifications:



External Ids:

UMLS 71 C2930894

Summaries for Galactorrhoea-Hyperprolactinaemia

MalaCards based summary : Galactorrhoea-Hyperprolactinaemia, also known as galactorrhea-hyperprolactinemia, is related to hyperprolactinemia and ahumada del castillo syndrome. An important gene associated with Galactorrhoea-Hyperprolactinaemia is PRLR (Prolactin Receptor). The drugs Aripiprazole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary.

Related Diseases for Galactorrhoea-Hyperprolactinaemia

Diseases related to Galactorrhoea-Hyperprolactinaemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 hyperprolactinemia 11.4
2 ahumada del castillo syndrome 10.9
3 pituitary adenoma, prolactin-secreting 10.6
4 hypogonadism 10.5
5 hypothyroidism 10.4
6 sexual disorder 10.3
7 impotence 10.3
8 infertility 10.3
9 acromegaly 10.3
10 galactorrhea 10.2
11 hypopituitarism 10.2
12 polycystic ovary syndrome 10.2
13 anovulation 10.1
14 amenorrhea 10.1
15 heart valve disease 10.1
16 hyperostosis frontalis interna 10.1
17 hyperostosis 10.1
18 pituitary adenoma 10.1
19 adenoma 10.1
20 schizophrenia 10.0
21 male infertility 10.0
22 psychotic disorder 10.0
23 diabetes insipidus 10.0
24 amenorrhea-galactorrhea syndrome 10.0
25 breast cancer 10.0
26 renal tubular acidosis 10.0
27 central congenital hypothyroidism 10.0
28 hypertension, essential 10.0
29 major affective disorder 8 10.0
30 major affective disorder 9 10.0
31 bipolar disorder 10.0
32 empty sella syndrome 10.0
33 chromophobe adenoma 10.0
34 tricuspid valve insufficiency 10.0
35 hyperthyroidism 10.0
36 hashimoto thyroiditis 9.9
37 systemic lupus erythematosus 9.9
38 osteoporosis 9.9
39 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
40 bone mineral density quantitative trait locus 8 9.9
41 bone mineral density quantitative trait locus 15 9.9
42 thyroiditis 9.9
43 lupus erythematosus 9.9
44 hypoglycemia 9.9
45 lymphocytic hypophysitis 9.9
46 pituitary tumors 9.9
47 atrial standstill 1 9.7
48 glioma susceptibility 1 9.7
49 teratoma, ovarian 9.7
50 mccune-albright syndrome 9.7

Graphical network of the top 20 diseases related to Galactorrhoea-Hyperprolactinaemia:



Diseases related to Galactorrhoea-Hyperprolactinaemia

Symptoms & Phenotypes for Galactorrhoea-Hyperprolactinaemia

Drugs & Therapeutics for Galactorrhoea-Hyperprolactinaemia

Drugs for Galactorrhoea-Hyperprolactinaemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3 Antipsychotic Agents Phase 4
4 Dopamine Agents Phase 4
5 Dopamine Antagonists Phase 4
6 Neurotransmitter Agents Phase 4
7 Dopamine agonists Phase 4
8 Serotonin 5-HT1 Receptor Agonists Phase 4
9 Serotonin Receptor Agonists Phase 4
10 Psychotropic Drugs Phase 4
11 Antidepressive Agents Phase 4
12
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aripiprazole Treatment for Antipsychotic Induced Hyperprolactinaemia in Patients With Severe Mental Illness and Learning Disabilities Completed NCT01085383 Phase 4 Aripiprazole
2 Prognostic Value of Pituitary Histopathology and Plasma Hyperprolactinaemia in Predicting the Risk of Glucose Metabolic Disturbances in Patients With Acromegaly. Unknown status NCT02092129
3 Changes in Hyperprolactinemia Secondary to Antipsychotics After Switching to Quetiapine: a Naturalistic, Prospective, Multicentric Observational Study of 6 Months Follow-up Completed NCT00952757
4 A Retrospective Cohort Study of Hyperprolactinaemia Management in Reproductive Services at University Hospital of Coventry and Warwickshire (UHCW) Completed NCT03569787

Search NIH Clinical Center for Galactorrhoea-Hyperprolactinaemia

Genetic Tests for Galactorrhoea-Hyperprolactinaemia

Anatomical Context for Galactorrhoea-Hyperprolactinaemia

MalaCards organs/tissues related to Galactorrhoea-Hyperprolactinaemia:

40
Pituitary

Publications for Galactorrhoea-Hyperprolactinaemia

Articles related to Galactorrhoea-Hyperprolactinaemia:

(show all 29)
# Title Authors PMID Year
1
Variant Prolactin Receptor in Agalactia and Hyperprolactinemia. 6
30575453 2018
2
Risks associated with vortioxetine in the established therapeutic indication. 61
32811416 2020
3
Pituitary hyperplasia: an uncommon presentation of a common disease. 61
26279852 2015
4
The prevalence of hyperprolactinemia and galactorrhea in patients with abnormal uterine bleeding. 61
18569035 2008
5
Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia. 61
12165665 2002
6
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273088 2001
7
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273089 2001
8
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273090 2001
9
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273087 2001
10
Galactorrhoea and pituitary mass: a typical prolactinoma? 61
10727570 2000
11
[Primary hypothyroidism presenting with amenorrhea, galactorrhea, hyperprolactinemia and enlarged pituitary]. 61
1572562 1992
12
Primary amenorrhea and pseudoprolactinoma in a patient with primary hypothyroidism. Reversal of clinical, biochemical, and radiologic abnormalities with levothyroxine. 61
3728546 1986
13
Pituitary thyrotroph hyperplasia mimicking prolactin-secreting adenoma. 61
6501808 1984
14
Amenorrhea-galactorrhea, hyperprolactinemia, and suprasellar pituitary enlargement as presenting features of primary hypothyroidism. 61
6700889 1984
15
Hyperostosis frontalis, galactorrhoea/hyperprolactinaemia, and Morgagni-Stewart-Morel syndrome. 61
6131191 1983
16
Bromocriptine treatment of women with suspected pituitary prolactin-secreting microadenomas. 61
7201244 1982
17
Galactorrhoea, hyperprolactinaemia, and pituitary adenoma presenting during metoclopramide therapy. 61
7202198 1982
18
Amenorrhea, galactorrhea, hyperprolactinemia syndrome and breast carcinoma in a young woman. 61
7194824 1981
19
Longitudinal evaluation of patients with untreated prolactin-secreting pituitary adenomas. 61
7193977 1981
20
[Role of prolactin determination in sterility diagnosis (author's transl)]. 61
6791410 1981
21
Clinical course and outcome of pregnancy in twenty-five patients with pituitary microadenomas. 61
6101517 1980
22
[Hyperprolactinaemic endocrinopathy in gynaecological practice (author's transl)]. 61
7193390 1980
23
Pituitary function testing in amenorrhea-galactorrhea-hyperprolactinemia. 61
115722 1979
24
Spontaneous pregnancy in women with a prolactin-producing pituitary adenoma. 61
658474 1978
25
Galactorrhoea and hypogonadism associated with a radiologically-inapparent prolactin-secreting pituitary tumour. 61
415470 1978
26
Hyperprolactinemic anovulatory syndrome. 61
765352 1976
27
Primary empty sella, galactorrhea, hyperprolactinemia and renal tubular acidosis. 61
1190258 1975
28
Hypothalamic pituitary disorders expressed by galactorrhea. A dynamic evaluation. 61
812032 1975
29
Incidence and significance of hyperprolactinaemia in women with amenorrhea. 61
1104218 1975

Variations for Galactorrhoea-Hyperprolactinaemia

ClinVar genetic disease variations for Galactorrhoea-Hyperprolactinaemia:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PRLR NM_000949.7(PRLR):c.635A>G (p.His212Arg) SNV Pathogenic 89027 rs398122522 5:35070276-35070276 5:35070174-35070174
2 PRLR NM_000949.7(PRLR):c.511C>T (p.Arg171Ter) SNV Pathogenic 599315 rs376188691 5:35072709-35072709 5:35072607-35072607
3 PRLR NM_000949.7(PRLR):c.806C>T (p.Pro269Leu) SNV Pathogenic 599316 rs754974807 5:35068367-35068367 5:35068265-35068265

Expression for Galactorrhoea-Hyperprolactinaemia

Search GEO for disease gene expression data for Galactorrhoea-Hyperprolactinaemia.

Pathways for Galactorrhoea-Hyperprolactinaemia

GO Terms for Galactorrhoea-Hyperprolactinaemia

Sources for Galactorrhoea-Hyperprolactinaemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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