MCID: GLC025
MIFTS: 21

Galactorrhoea-Hyperprolactinaemia

Categories: Rare diseases

Aliases & Classifications for Galactorrhoea-Hyperprolactinaemia

MalaCards integrated aliases for Galactorrhoea-Hyperprolactinaemia:

Name: Galactorrhoea-Hyperprolactinaemia 52
Galactorrhea-Hyperprolactinemia 52 71
Hyperprolactinaemia 52

Classifications:



External Ids:

UMLS 71 C2930894

Summaries for Galactorrhoea-Hyperprolactinaemia

MalaCards based summary : Galactorrhoea-Hyperprolactinaemia, also known as galactorrhea-hyperprolactinemia, is related to hyperprolactinemia and ahumada del castillo syndrome. The drugs Dopamine and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include pituitary, heart and ovary.

Related Diseases for Galactorrhoea-Hyperprolactinaemia

Diseases related to Galactorrhoea-Hyperprolactinaemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 hyperprolactinemia 12.3
2 ahumada del castillo syndrome 11.3
3 pituitary adenoma, prolactin-secreting 11.1
4 hypogonadism 10.6
5 hypogonadotropism 10.6
6 hypothyroidism 10.6
7 infertility 10.5
8 sexual disorder 10.4
9 impotence 10.4
10 acromegaly 10.4
11 galactorrhea 10.3
12 hypopituitarism 10.3
13 hyperostosis frontalis interna 10.3
14 hyperostosis 10.3
15 empty sella syndrome 10.3
16 pituitary adenoma 10.3
17 adenoma 10.3
18 schizophrenia 10.3
19 polycystic ovary syndrome 10.3
20 anovulation 10.3
21 osteoporosis 10.2
22 bone mineral density quantitative trait locus 8 10.2
23 bone mineral density quantitative trait locus 15 10.2
24 amenorrhea 10.2
25 heart valve disease 10.2
26 male infertility 10.1
27 diabetes insipidus 10.1
28 hypoglycemia 10.1
29 amenorrhea-galactorrhea syndrome 10.1
30 renal tubular acidosis 10.1
31 central congenital hypothyroidism 10.1
32 hypertension, essential 10.1
33 major affective disorder 8 10.1
34 major affective disorder 9 10.1
35 bipolar disorder 10.1
36 chromophobe adenoma 10.1
37 tricuspid valve insufficiency 10.1
38 hyperthyroidism 10.1
39 rare surgical neurologic disease 10.1
40 systemic lupus erythematosus 10.0
41 heart disease 10.0
42 psychotic disorder 10.0
43 kidney disease 10.0
44 lupus erythematosus 10.0
45 lymphocytic hypophysitis 10.0
46 depression 10.0
47 pituitary tumors 10.0
48 neurofibromatosis, type ii 9.8
49 alcohol dependence 9.8
50 atrial standstill 1 9.8

Graphical network of the top 20 diseases related to Galactorrhoea-Hyperprolactinaemia:



Diseases related to Galactorrhoea-Hyperprolactinaemia

Symptoms & Phenotypes for Galactorrhoea-Hyperprolactinaemia

Drugs & Therapeutics for Galactorrhoea-Hyperprolactinaemia

Drugs for Galactorrhoea-Hyperprolactinaemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
3 Tranquilizing Agents Phase 4
4 Central Nervous System Depressants Phase 4
5 Psychotropic Drugs Phase 4
6 Antipsychotic Agents Phase 4
7 Antidepressive Agents Phase 4
8 Neurotransmitter Agents Phase 4
9 Dopamine D2 Receptor Antagonists Phase 4
10 Dopamine Agents Phase 4
11 Serotonin 5-HT2 Receptor Antagonists Phase 4
12 Serotonin 5-HT1 Receptor Agonists Phase 4
13 Dopamine Antagonists Phase 4
14 Serotonin Agents Phase 4
15 Dopamine agonists Phase 4
16 Serotonin Receptor Agonists Phase 4
17 Serotonin Antagonists Phase 4
18
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
19
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
20
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
21
Metformin Approved Phase 3 657-24-9 14219 4091
22
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
23
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
24
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
25
Lactitol Investigational Phase 3 585-86-4, 585-88-6 493591
26
Enclomiphene Investigational Phase 2, Phase 3 15690-57-0
27 Aromatase Inhibitors Phase 3
28 Steroid Synthesis Inhibitors Phase 3
29 Pharmaceutical Solutions Phase 2, Phase 3
30 Fertility Agents Phase 2, Phase 3
31 Estrogens Phase 2, Phase 3
32 Selective Estrogen Receptor Modulators Phase 2, Phase 3
33 Hormone Antagonists Phase 2, Phase 3
34 Estrogen Antagonists Phase 2, Phase 3
35 Zuclomiphene Phase 2, Phase 3
36 Clomiphene Phase 2, Phase 3
37 Estrogen Receptor Antagonists Phase 2, Phase 3
38 Estrogen Receptor Modulators Phase 2, Phase 3
39 Hormones Phase 2, Phase 3
40 Citrate Phase 2, Phase 3
41 Anticoagulants Phase 2, Phase 3
42 Chelating Agents Phase 2, Phase 3
43 Calcium, Dietary Phase 2, Phase 3
44 Anesthetics Phase 2, Phase 3
45 Progestins Phase 2, Phase 3
46
Licorice Approved Phase 2
47 Quetiapine Fumarate 111974-72-2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Aripiprazole Treatment for Antipsychotic Induced Hyperprolactinaemia in Patients With Severe Mental Illness and Learning Disabilities Completed NCT01085383 Phase 4 Aripiprazole
2 Comparison Between Letrozole and Laparoscopic Ovarian Drilling in Women With Clomiphene Resistant Polycystic Ovarian Syndrome (PCOS) Unknown status NCT02305693 Phase 3 Letrozole
3 Comparison Between Laproscopic Ovarian Diathermy and Urinary Purified FSH in Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome: A Randomised Controlled Trial Unknown status NCT02304536 Phase 3 FSH
4 Extended Clomiphene Citrate Regimen Versus Laparoscopic Ovarian Drilling for Ovulation Induction in Clomiphene Citrate-resistant Women With Polycystic Ovary Syndrome Completed NCT02381184 Phase 2, Phase 3 clomiphene citrate
5 The Herbal Medicine Peony-Glycyrrhiza Decoction (PGD) as an Adjunctive Therapy to Treat Antipsychotic-induced Hyperprolactinemia in Patients With Schizophrenia: a Double-blind, Randomized, Placebo-controlled Study Completed NCT01852331 Phase 2 PGD granules;Placebo
6 Prognostic Value of Pituitary Histopathology and Plasma Hyperprolactinaemia in Predicting the Risk of Glucose Metabolic Disturbances in Patients With Acromegaly. Unknown status NCT02092129
7 TSH and AMH in Infertile Women Unknown status NCT02710175
8 A Retrospective Cohort Study of Hyperprolactinaemia Management in Reproductive Services at University Hospital of Coventry and Warwickshire (UHCW) Completed NCT03569787
9 Changes in Hyperprolactinemia Secondary to Antipsychotics After Switching to Quetiapine: a Naturalistic, Prospective, Multicentric Observational Study of 6 Months Follow-up Completed NCT00952757
10 Relationship of Metabolic Parameters, Endocrine and Prolactin Levels in Taiwan's Women With Polycystic Ovary Syndrome and Hyperprolactinemia. Completed NCT01117272
11 A Comparative Study of Homoeopathic Treatment Versus Integrated Approach of Homoeopathy and Yoga in the Treatment of Menstrual Disorders in Females With Polycystic Ovarian Syndrome. Recruiting NCT03579303

Search NIH Clinical Center for Galactorrhoea-Hyperprolactinaemia

Genetic Tests for Galactorrhoea-Hyperprolactinaemia

Anatomical Context for Galactorrhoea-Hyperprolactinaemia

MalaCards organs/tissues related to Galactorrhoea-Hyperprolactinaemia:

40
Pituitary, Heart, Ovary, Breast, Bone, Kidney, Thyroid

Publications for Galactorrhoea-Hyperprolactinaemia

Articles related to Galactorrhoea-Hyperprolactinaemia:

(show all 27)
# Title Authors PMID Year
1
Pituitary hyperplasia: an uncommon presentation of a common disease. 61
26279852 2015
2
The prevalence of hyperprolactinemia and galactorrhea in patients with abnormal uterine bleeding. 61
18569035 2008
3
Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia. 61
12165665 2002
4
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273087 2001
5
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273088 2001
6
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273089 2001
7
Galactorrhoea, hyperprolactinaemia, and protease inhibitors. 61
11273090 2001
8
Galactorrhoea and pituitary mass: a typical prolactinoma? 61
10727570 2000
9
[Primary hypothyroidism presenting with amenorrhea, galactorrhea, hyperprolactinemia and enlarged pituitary]. 61
1572562 1992
10
Primary amenorrhea and pseudoprolactinoma in a patient with primary hypothyroidism. Reversal of clinical, biochemical, and radiologic abnormalities with levothyroxine. 61
3728546 1986
11
Pituitary thyrotroph hyperplasia mimicking prolactin-secreting adenoma. 61
6501808 1984
12
Amenorrhea-galactorrhea, hyperprolactinemia, and suprasellar pituitary enlargement as presenting features of primary hypothyroidism. 61
6700889 1984
13
Hyperostosis frontalis, galactorrhoea/hyperprolactinaemia, and Morgagni-Stewart-Morel syndrome. 61
6131191 1983
14
Bromocriptine treatment of women with suspected pituitary prolactin-secreting microadenomas. 61
7201244 1982
15
Galactorrhoea, hyperprolactinaemia, and pituitary adenoma presenting during metoclopramide therapy. 61
7202198 1982
16
Longitudinal evaluation of patients with untreated prolactin-secreting pituitary adenomas. 61
7193977 1981
17
Amenorrhea, galactorrhea, hyperprolactinemia syndrome and breast carcinoma in a young woman. 61
7194824 1981
18
[Role of prolactin determination in sterility diagnosis (author's transl)]. 61
6791410 1981
19
Clinical course and outcome of pregnancy in twenty-five patients with pituitary microadenomas. 61
6101517 1980
20
[Hyperprolactinaemic endocrinopathy in gynaecological practice (author's transl)]. 61
7193390 1980
21
Pituitary function testing in amenorrhea-galactorrhea-hyperprolactinemia. 61
115722 1979
22
Spontaneous pregnancy in women with a prolactin-producing pituitary adenoma. 61
658474 1978
23
Galactorrhoea and hypogonadism associated with a radiologically-inapparent prolactin-secreting pituitary tumour. 61
415470 1978
24
Hyperprolactinemic anovulatory syndrome. 61
765352 1976
25
Primary empty sella, galactorrhea, hyperprolactinemia and renal tubular acidosis. 61
1190258 1975
26
Hypothalamic pituitary disorders expressed by galactorrhea. A dynamic evaluation. 61
812032 1975
27
Incidence and significance of hyperprolactinaemia in women with amenorrhea. 61
1104218 1975

Variations for Galactorrhoea-Hyperprolactinaemia

Expression for Galactorrhoea-Hyperprolactinaemia

Search GEO for disease gene expression data for Galactorrhoea-Hyperprolactinaemia.

Pathways for Galactorrhoea-Hyperprolactinaemia

GO Terms for Galactorrhoea-Hyperprolactinaemia

Sources for Galactorrhoea-Hyperprolactinaemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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