MCID: GLL029
MIFTS: 30

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 54 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893
UMLS 71 C0238137

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A gallbladder benign neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to adenoma and in situ carcinoma. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Adipogenesis and Transcription_P53 signaling pathway. Affiliated tissues include gallbladder, pancreas and thyroid, and related phenotypes are cardiovascular system and muscle

Related Diseases for Gallbladder Adenoma

Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.7 KRT7 CTNNB1 CDKN2A
2 in situ carcinoma 29.7 PDPN CTNNB1 CDKN2A
3 gallbladder disease 29.6 PDPN KRT7 CTNNB1
4 adenocarcinoma 29.4 RB1 KRT7 CTNNB1 CDKN2A
5 vulvar intraepithelial neoplasia 10.3 CTNNB1 CDKN2A
6 urinary bladder inverted papilloma 10.2 RB1 CDKN2A
7 atypical polypoid adenomyoma 10.2 CTNNB1 CDKN2A
8 bone squamous cell carcinoma 10.2 CTNNB1 CDKN2A
9 suppressor of tumorigenicity 3 10.2 RB1 CDKN2A
10 epstein-barr virus-associated gastric carcinoma 10.2 CTNNB1 CDKN2A
11 familial retinoblastoma 10.2 RB1 CDKN2A
12 cervical basaloid squamous cell carcinoma 10.2 KRT7 CDKN2A
13 basaloid squamous cell carcinoma 10.2 KRT7 CDKN2A
14 inverted papilloma 10.2 KRT7 CDKN2A
15 inverted transitional papilloma 10.2 KRT7 CDKN2A
16 anal canal paget's disease 10.2 KRT7 CDKN2A
17 cervical adenoid cystic carcinoma 10.2 KRT7 CDKN2A
18 atrophic vulva 10.2 KRT7 CDKN2A
19 vaginal tubulovillous adenoma 10.2 KRT7 CDKN2A
20 uterus carcinoma in situ 10.2 RB1 CDKN2A
21 ovarian seromucinous carcinoma 10.2 KRT7 CDKN2A
22 cervix uteri carcinoma in situ 10.2 RB1 CDKN2A
23 supraglottis neoplasm 10.2 PDPN CDKN2A
24 papillary squamous carcinoma 10.2 KRT7 CDKN2A
25 penile benign neoplasm 10.2 PDPN CDKN2A
26 anogenital venereal wart 10.2 RB1 CDKN2A
27 atypical neurofibroma 10.2 PDPN CDKN2A
28 gliomatosis cerebri 10.2 RB1 CDKN2A
29 supraglottis cancer 10.2 PDPN CDKN2A
30 ovarian brenner tumor 10.2 KRT7 CDKN2A
31 bladder clear cell adenocarcinoma 10.2 KRT7 CDKN2A
32 keratinizing squamous cell carcinoma 10.1 KRT7 CDKN2A
33 penile disease 10.1 RB1 CDKN2A
34 malignant spiradenoma 10.1 KRT7 CDKN2A
35 bile duct adenoma 10.1 KRT7 CDKN2A
36 urethra clear cell adenocarcinoma 10.1 KRT7 CDKN2A
37 vaginal cancer 10.1 KRT7 CDKN2A
38 nasal cavity adenocarcinoma 10.1 KRT7 CDKN2A
39 vaginal adenoma 10.1 KRT7 CTNNB1
40 vaginal benign neoplasm 10.1 KRT7 CTNNB1
41 retroperitoneum carcinoma 10.1 KRT7 CDKN2A
42 nasal cavity cancer 10.1 KRT7 CDKN2A
43 lip and oral cavity cancer 10.1 RB1 CDKN2A
44 borst-jadassohn intraepidermal carcinoma 10.1 KRT7 CDKN2A
45 papillary craniopharyngioma 10.1 KRT7 CTNNB1
46 laryngeal benign neoplasm 10.1 PDPN CDKN2A
47 intrahepatic bile duct adenoma 10.1 KRT7 CTNNB1
48 vulvar disease 10.1 KRT7 CDKN2A
49 conjunctival squamous cell carcinoma 10.1 RB1 PDPN
50 anal canal carcinoma 10.1 KRT7 CDKN2A

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

MGI Mouse Phenotypes related to Gallbladder Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ATP5F1B CDKN2A CTNNB1 LFNG PDPN PPARA
2 muscle MP:0005369 9.35 CDKN2A CTNNB1 PDPN PPARA RB1
3 respiratory system MP:0005388 9.02 CDKN2A CTNNB1 LFNG PDPN RB1

Drugs & Therapeutics for Gallbladder Adenoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

19
Gallbladder

MalaCards organs/tissues related to Gallbladder Adenoma:

40
Pancreas, Thyroid, Endothelial, Neutrophil

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. 61 54
20422865 2010
2
Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. 61 54
15655836 2005
3
Biotin-rich, optically clear nuclei express estrogen receptor-beta: tumors with morules may develop under the influence of estrogen and aberrant beta-catenin expression. 54 61
15257551 2004
4
Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. 54 61
11584965 2001
5
Characteristics of contrast-enhanced ultrasound in carcinogenesis of gallbladder papillary adenoma: A case report. 61
33579828 2021
6
Value of high frame rate contrast-enhanced ultrasound in distinguishing gallbladder adenoma from cholesterol polyp lesion. 61
33569621 2021
7
A transcriptome profile in gallbladder cancer based on annotation analysis of microarray studies. 61
33179115 2021
8
Large and unusual presentation of gallbladder adenoma: A case report. 61
33269278 2020
9
Is contrast enhanced ultrasonography an accurate way to diagnose gallbladder adenoma?: A systematic review and meta-analysis. 61
33129756 2020
10
Ultrasound Radiomics Effective for Preoperative Identification of True and Pseudo Gallbladder Polyps Based on Spatial and Morphological Features. 61
33042816 2020
11
Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma. 61
32606941 2020
12
Ectopic thyroid in the gallbladder accompanied with gallbladder adenoma: A case report. 61
31852107 2019
13
Amputation neuroma derived from a remnant cystic duct 30 years after cholecystectomy: A case report. 61
31671354 2019
14
Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion. 61
29456413 2018
15
KrasG12D upregulates Notch signaling to induce gallbladder tumorigenesis in mice. 61
29142904 2017
16
Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite. 61
28274810 2017
17
Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder. 61
26643927 2016
18
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. 61
26082060 2015
19
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. 61
25865694 2015
20
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. 61
25785101 2015
21
Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance. 61
25973087 2015
22
Managing the incidentally detected gallbladder cancer: algorithms and controversies. 61
25182380 2014
23
Unicryptal gallbladder adenomas in a patient with Gardner's syndrome. 61
23787021 2013
24
Large villous adenoma of gallbladder: A case report. 61
23276760 2013
25
Different expression of S100A8 in malignant and benign gallbladder diseases. 61
22806545 2013
26
High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: differentiation between benignity and malignancy. 61
22576026 2012
27
Incidental gallbladder cancer during laparoscopic cholecystectomy: managing an unexpected finding. 61
22912553 2012
28
Proteomic-based analysis for identification of potential serum biomarkers in gallbladder cancer. 61
21687958 2011
29
Carcinoma gallbladder. 61
20639849 2010
30
[Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. 61
20168058 2010
31
[Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. 61
19844152 2009
32
Gallbladder adenoma with focal adenocarcinoma. 61
18717288 2008
33
A case of pyloric-type gallbladder adenoma. 61
18392262 2008
34
[A case of gallbladder adenoma with wide base]. 61
18176045 2008
35
Polypoid lesion of the gallbladder in childhood: case report and literature review. 61
18491679 2008
36
[Gallbladder adenoma with focal adenocarcinoma: a case report]. 61
17970176 2007
37
[Gallbladder polyps: correlation between ultrasonographic and histopathological findings]. 61
17186092 2006
38
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. 61
16447086 2006
39
[Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor]. 61
16944600 2006
40
Aberrant p53 expression and the development of gallbladder carcinoma and adenoma. 61
16568721 2006
41
Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma. 61
15968727 2005
42
A tubulopapillary adenoma of the gallbladder in a child of 3 years. 61
15015477 2004
43
[Surgical treatment of polypoid lesions of gallbladder]. 61
14692147 2003
44
Mutation and altered expression of beta-catenin during gallbladder carcinogenesis. 61
12023580 2002
45
Expression of the c-erb-B2 and p53 protein in gallbladder carcinomas. 61
11496329 2001
46
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. 61
11410326 2001
47
Beta-catenin mutations in biliary tract cancers: a population-based study in China. 54
11309300 2001
48
CD44 variant overexpression in gallbladder carcinoma associated with tumor dedifferentiation. 61
11180088 2001
49
More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. 54
11196159 2001
50
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts. 61
10613729 2000

Variations for Gallbladder Adenoma

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

Pathways related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.25 RB1 PPARA CTNNB1
2 11.06 RB1 CTNNB1 CDKN2A
3 11.03 RB1 CDKN2A
4 10.84 RB1 CTNNB1 CDKN2A
5 10.6 RB1 CDKN2A

GO Terms for Gallbladder Adenoma

Cellular components related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microvillus membrane GO:0031528 8.62 PDPN CTNNB1

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of epithelial to mesenchymal transition GO:0010718 9.32 PDPN CTNNB1
2 T cell differentiation GO:0030217 9.26 LFNG CTNNB1
3 negative regulation of apoptotic signaling pathway GO:2001234 9.16 RB1 CTNNB1
4 tissue homeostasis GO:0001894 8.96 RB1 CTNNB1
5 negative regulation of cell proliferation GO:0008285 8.92 RB1 PDPN CTNNB1 CDKN2A

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II activating transcription factor binding GO:0001102 9.26 RB1 CTNNB1
2 transcription factor binding GO:0008134 9.26 RB1 PPARA CTNNB1 CDKN2A
3 MDM2/MDM4 family protein binding GO:0097371 9.16 PPARA CDKN2A
4 disordered domain specific binding GO:0097718 8.8 RB1 CTNNB1 CDKN2A

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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