MCID: GLL029
MIFTS: 34

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893
UMLS 73 C0238137

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A biliary tract neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to adenocarcinoma and adenoma. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Human cytomegalovirus infection and Endometrial cancer. Affiliated tissues include lung, brain and bone, and related phenotypes are Decreased cell migration and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance

Related Diseases for Gallbladder Adenoma

Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.6 CDKN2A CTNNB1 HRAS RB1
2 adenoma 10.3
3 tongue disease 10.1 CDKN2A CTNNB1
4 spitz nevus 10.1 CDKN2A HRAS
5 melanomatosis 10.1 CDKN2A HRAS
6 epstein-barr virus-associated gastric carcinoma 10.1 CDKN2A CTNNB1
7 nasal cavity adenocarcinoma 10.1 CDKN2A HRAS
8 periosteal chondrosarcoma 10.1 CDKN2A RB1
9 meningeal melanomatosis 10.1 CDKN2A HRAS
10 suppressor of tumorigenicity 3 10.1 CDKN2A RB1
11 dedifferentiated liposarcoma 10.1 CDKN2A RB1
12 nasopharyngeal disease 10.1 CDKN2A CTNNB1
13 ewing's family of tumors 10.1 CDKN2A RB1
14 verrucous carcinoma 10.1 CDKN2A RB1
15 pharynx cancer 10.1 CDKN2A CTNNB1
16 biliary tract neoplasm 10.1 CDKN2A HRAS
17 cervix disease 10.1 CDKN2A CTNNB1
18 bladder adenocarcinoma 10.1 CTNNB1 HRAS
19 central nervous system melanocytic neoplasm 10.1 CDKN2A HRAS
20 cervical squamous cell carcinoma 10.1 CDKN2A CTNNB1
21 skin squamous cell carcinoma 10.1 CDKN2A HRAS
22 uterine anomalies 10.1 CDKN2A CTNNB1
23 gastrointestinal system benign neoplasm 10.1 CTNNB1 HRAS
24 retinal cancer 10.1 CDKN2A RB1
25 intestinal benign neoplasm 10.1 CTNNB1 HRAS
26 ocular cancer 10.1 CDKN2A RB1
27 tongue cancer 10.1 CDKN2A CTNNB1
28 female reproductive system disease 10.0 CDKN2A CTNNB1
29 colorectal adenoma 10.0 CTNNB1 HRAS
30 reproductive system disease 10.0 CDKN2A CTNNB1
31 carcinosarcoma 10.0 CTNNB1 HRAS
32 colonic disease 10.0 CTNNB1 HRAS
33 endometrial adenocarcinoma 10.0 CDKN2A CTNNB1
34 colorectal adenocarcinoma 10.0 CTNNB1 HRAS
35 nervous system cancer 10.0 CDKN2A RB1
36 bile duct cysts 10.0 HRAS PCNT
37 cell type benign neoplasm 9.9 CDKN2A CTNNB1 HRAS
38 respiratory system cancer 9.9 CDKN2A CTNNB1 HRAS
39 gastrointestinal system cancer 9.9 CDKN2A CTNNB1 HRAS
40 endocrine gland cancer 9.9 CDKN2A CTNNB1 HRAS
41 gastrointestinal system disease 9.9 CDKN2A CTNNB1 HRAS
42 pancreas adenocarcinoma 9.9 CDKN2A CTNNB1 HRAS
43 melanoma, cutaneous malignant 1 9.9 CDKN2A CTNNB1 HRAS
44 adamantinoma of long bones 9.9 CDKN2A CTNNB1 RB1
45 large intestine cancer 9.9 CDKN2A CTNNB1 HRAS
46 nasopharyngeal carcinoma 9.9 CDKN2A CTNNB1 HRAS
47 gastric adenocarcinoma 9.9 CDKN2A CTNNB1 HRAS
48 lung cancer susceptibility 3 9.9 CDKN2A CTNNB1 HRAS
49 bladder urothelial carcinoma 9.9 CTNNB1 HRAS RB1
50 sarcoma 9.9 CTNNB1 HRAS RB1

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

GenomeRNAi Phenotypes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.33 CTNNB1 HRAS PFN1
2 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.13 CTNNB1 HRAS PFN1
3 Increased cell migration GR00055-A-3 8.8 CTNNB1 HRAS PFN1

MGI Mouse Phenotypes related to Gallbladder Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 CDKN2A CTNNB1 HRAS PFN1 RB1
2 digestive/alimentary MP:0005381 9.67 CDKN2A CTNNB1 HRAS RB1
3 neoplasm MP:0002006 9.62 CDKN2A CTNNB1 HRAS RB1
4 no phenotypic analysis MP:0003012 9.56 CDKN2A CTNNB1 HRAS RB1
5 pigmentation MP:0001186 9.33 CDKN2A CTNNB1 RB1
6 respiratory system MP:0005388 9.26 CDKN2A CTNNB1 HRAS RB1
7 skeleton MP:0005390 9.02 CDKN2A CTNNB1 HRAS PFN1 RB1

Drugs & Therapeutics for Gallbladder Adenoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

MalaCards organs/tissues related to Gallbladder Adenoma:

41
Lung, Brain, Bone, Colon, Tongue, Pancreas, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

19
The Gallbladder

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

# Title Authors Year
1
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. ( 26082060 )
2015
2
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. ( 25865694 )
2015
3
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. ( 25785101 )
2015
4
Gallbladder adenoma with focal adenocarcinoma. ( 18717288 )
2008
5
A case of pyloric-type gallbladder adenoma. ( 18392262 )
2008
6
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. ( 16447086 )
2006
7
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. ( 11410326 )
2001
8
Histological and genetic changes in malignant transformation of gallbladder adenoma. ( 10436806 )
1999

Variations for Gallbladder Adenoma

Cosmic variations for Gallbladder Adenoma:

9 (show all 15)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM520 KRAS biliary tract,gallbladder,other,adenoma c.35G>T p.G12V 12:25245350-25245350 6
2 COSM552 KRAS biliary tract,gallbladder,other,adenoma c.182A>G p.Q61R 12:25227342-25227342 6
3 COSM521 KRAS biliary tract,gallbladder,other,adenoma c.35G>A p.G12D 12:25245350-25245350 6
4 COSM554 KRAS biliary tract,gallbladder,other,adenoma c.183A>C p.Q61H 12:25227341-25227341 6
5 COSM517 KRAS biliary tract,gallbladder,other,adenoma c.34G>A p.G12S 12:25245351-25245351 6
6 COSM516 KRAS biliary tract,gallbladder,other,adenoma c.34G>T p.G12C 12:25245351-25245351 6
7 COSM553 KRAS biliary tract,gallbladder,other,adenoma c.182A>T p.Q61L 12:25227342-25227342 6
8 COSM5667 CTNNB1 biliary tract,gallbladder,other,adenoma c.134C>T p.S45F 3:41224646-41224646 6
9 COSM5662 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>T p.S37F 3:41224622-41224622 6
10 COSM5670 CTNNB1 biliary tract,gallbladder,other,adenoma c.101G>T p.G34V 3:41224613-41224613 6
11 COSM5679 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>G p.S37C 3:41224622-41224622 6
12 COSM5672 CTNNB1 biliary tract,gallbladder,other,adenoma c.94G>A p.D32N 3:41224606-41224606 6
13 COSM5676 CTNNB1 biliary tract,gallbladder,other,adenoma c.122C>T p.T41I 3:41224634-41224634 6
14 COSM5664 CTNNB1 biliary tract,gallbladder,other,adenoma c.121A>G p.T41A 3:41224633-41224633 6
15 COSM5677 CTNNB1 biliary tract,gallbladder,other,adenoma c.98C>G p.S33C 3:41224610-41224610 6

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

Pathways related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 CDKN2A CTNNB1 HRAS RB1
2
Show member pathways
12.5 CDKN2A CTNNB1 HRAS RB1
3
Show member pathways
12.49 CDKN2A HRAS RB1
4
Show member pathways
12.45 CTNNB1 HRAS PFN1
5 12.45 CDKN2A CTNNB1 HRAS RB1
6
Show member pathways
12.34 CTNNB1 HRAS PFN1
7
Show member pathways
12.34 CDKN2A CTNNB1 HRAS RB1
8
Show member pathways
12.25 CTNNB1 HRAS RB1
9
Show member pathways
12.15 CTNNB1 HRAS RB1
10 12 CDKN2A HRAS RB1
11 11.86 CDKN2A HRAS RB1
12
Show member pathways
11.86 CDKN2A CTNNB1 HRAS RB1
13 11.77 CDKN2A CTNNB1 RB1
14 11.66 CDKN2A CTNNB1 HRAS RB1
15 11.64 CDKN2A CTNNB1 HRAS
16 11.52 CDKN2A HRAS RB1
17 11.47 CTNNB1 PFN1
18 11.47 HRAS RB1
19 11.4 CTNNB1 PFN1
20 11.4 CDKN2A CTNNB1 RB1
21 11.38 CTNNB1 HRAS
22
Show member pathways
11.32 HRAS RB1
23 11.31 CDKN2A RB1
24 11.3 CDKN2A HRAS RB1
25 11.27 HRAS RB1
26 11.05 CTNNB1 HRAS
27 10.97 CDKN2A CTNNB1 HRAS RB1
28 10.92 HRAS RB1
29 10.88 CDKN2A RB1

GO Terms for Gallbladder Adenoma

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.76 CDKN2A CTNNB1 HRAS RB1
2 positive regulation of gene expression GO:0010628 9.65 CDKN2A CTNNB1 HRAS
3 negative regulation of gene expression GO:0010629 9.54 CTNNB1 HRAS RB1
4 negative regulation of protein kinase activity GO:0006469 9.51 CDKN2A RB1
5 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.49 CDKN2A PCNT
6 androgen receptor signaling pathway GO:0030521 9.43 CTNNB1 RB1
7 mitotic cell cycle checkpoint GO:0007093 9.4 HRAS RB1
8 cell cycle arrest GO:0007050 9.33 CDKN2A HRAS RB1
9 cellular senescence GO:0090398 9.32 CDKN2A HRAS
10 positive regulation of ruffle assembly GO:1900029 9.26 HRAS PFN1
11 negative regulation of cell proliferation GO:0008285 9.26 CDKN2A CTNNB1 HRAS RB1
12 Ras protein signal transduction GO:0007265 8.8 CDKN2A HRAS RB1

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.43 CDKN2A CTNNB1 RB1
2 RNA polymerase II activating transcription factor binding GO:0001102 9.16 CTNNB1 RB1
3 androgen receptor binding GO:0050681 8.96 CTNNB1 RB1
4 disordered domain specific binding GO:0097718 8.8 CDKN2A CTNNB1 RB1

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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