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MCID: GLL029
MIFTS: 31

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Gallbladder Adenoma

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MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 54 15 17 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050893
UMLS 71 C0238137
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Summaries for Gallbladder Adenoma

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Disease Ontology : 12 A biliary tract benign neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to adenoma and vulvar intraepithelial neoplasia. An important gene associated with Gallbladder Adenoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Adipogenesis and Transcription_P53 signaling pathway. Affiliated tissues include gallbladder, bone and pancreas, and related phenotypes are cardiovascular system and muscle

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Related Diseases for Gallbladder Adenoma

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Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 adenoma 10.5
2 vulvar intraepithelial neoplasia 10.3 CTNNB1 CDKN2A
3 vaginal tubulovillous adenoma 10.3 CTNNB1 CDKN2A
4 vaginal adenoma 10.3 CTNNB1 CDKN2A
5 bone squamous cell carcinoma 10.3 CTNNB1 CDKN2A
6 epstein-barr virus-associated gastric carcinoma 10.3 CTNNB1 CDKN2A
7 urinary bladder inverted papilloma 10.2 RB1 CDKN2A
8 adenocarcinoma 10.2
9 suppressor of tumorigenicity 3 10.2 RB1 CDKN2A
10 dedifferentiated liposarcoma 10.2 RB1 CDKN2A
11 familial retinoblastoma 10.2 RB1 CDKN2A
12 bladder benign neoplasm 10.2 RB1 CDKN2A
13 gallbladder cancer 10.1
14 herpangina 10.1 CDKN2A CCR6
15 uterine corpus cancer 10.1 CTNNB1 CDKN2A
16 uterus carcinoma in situ 10.1 RB1 CDKN2A
17 cervix uteri carcinoma in situ 10.1 RB1 CDKN2A
18 anogenital venereal wart 10.1 RB1 CDKN2A
19 gliomatosis cerebri 10.1 RB1 CDKN2A
20 penile disease 10.1 RB1 CDKN2A
21 anus disease 10.1 CDKN2A CCR6
22 atypical neurofibroma 10.1 PDPN CDKN2A
23 ovarian cystadenocarcinoma 10.1 CTNNB1 CDKN2A
24 supraglottis cancer 10.1 PDPN CDKN2A
25 rectal disease 10.1 CDKN2A CCR6
26 tongue disease 10.0 CTNNB1 CDKN2A CCR6
27 malignant ovarian surface epithelial-stromal neoplasm 10.0 CTNNB1 CDKN2A CCR6
28 ovary epithelial cancer 10.0 CTNNB1 CDKN2A CCR6
29 cell type benign neoplasm 10.0 CTNNB1 CDKN2A CCR6
30 laryngeal benign neoplasm 10.0 PDPN CDKN2A
31 gallbladder disease 10.0
32 cholecystitis 10.0
33 in situ carcinoma 10.0
34 sarcomatoid mesothelioma 10.0 PDPN CDKN2A
35 conjunctival squamous cell carcinoma 10.0 RB1 PDPN
36 desmoid tumor 10.0 RB1 CTNNB1 CDKN2A
37 uterine carcinosarcoma 10.0 RB1 CTNNB1 CDKN2A
38 li-fraumeni syndrome 10.0 RB1 CTNNB1 CDKN2A
39 bone cancer 10.0 RB1 CTNNB1 CDKN2A
40 melanoma, cutaneous malignant 1 9.9 RB1 CTNNB1 CDKN2A
41 colonic benign neoplasm 9.9 CTNNB1 CCR6
42 nervous system cancer 9.9 RB1 CDKN2A CCR6
43 gallbladder disease 1 9.8
44 familial adenomatous polyposis 9.8
45 colorectal adenoma 9.8
46 villous adenoma 9.8
47 back pain 9.8
48 bladder urothelial carcinoma 9.8 RB1 CTNNB1 CDKN2A
49 renal cell carcinoma, papillary, 1 9.8 PDPN CTNNB1 CDKN2A
50 laryngeal disease 9.8 PDPN CDKN2A CCR6

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma
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Symptoms & Phenotypes for Gallbladder Adenoma

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MGI Mouse Phenotypes related to Gallbladder Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 CCR6 CDKN2A CTNNB1 LFNG PDPN PPARA
2 muscle MP:0005369 9.35 CDKN2A CTNNB1 PDPN PPARA RB1
3 respiratory system MP:0005388 9.02 CDKN2A CTNNB1 LFNG PDPN RB1
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Drugs & Therapeutics for Gallbladder Adenoma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Prospective Cohort Study of Risk Factors for Gallbladder Cancer Not yet recruiting NCT03762837

Search NIH Clinical Center for Gallbladder Adenoma

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Genetic Tests for Gallbladder Adenoma

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Anatomical Context for Gallbladder Adenoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

19
Gallbladder

MalaCards organs/tissues related to Gallbladder Adenoma:

40
Bone, Pancreas, Thyroid, Endothelial, Eye, Colon, Lung
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Publications for Gallbladder Adenoma

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Articles related to Gallbladder Adenoma:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. 54 61
20422865 2010
2
Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. 54 61
15655836 2005
3
Biotin-rich, optically clear nuclei express estrogen receptor-beta: tumors with morules may develop under the influence of estrogen and aberrant beta-catenin expression. 54 61
15257551 2004
4
Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. 54 61
11584965 2001
5
Ectopic thyroid in the gallbladder accompanied with gallbladder adenoma: A case report. 61
31852107 2019
6
Amputation neuroma derived from a remnant cystic duct 30 years after cholecystectomy: A case report. 61
31671354 2019
7
Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion. 61
29456413 2018
8
KrasG12D upregulates Notch signaling to induce gallbladder tumorigenesis in mice. 61
29142904 2017
9
Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite. 61
28274810 2017
10
Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder. 61
26643927 2016
11
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. 61
26082060 2015
12
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. 61
25865694 2015
13
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. 61
25785101 2015
14
Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance. 61
25973087 2015
15
Managing the incidentally detected gallbladder cancer: algorithms and controversies. 61
25182380 2014
16
Unicryptal gallbladder adenomas in a patient with Gardner's syndrome. 61
23787021 2013
17
Large villous adenoma of gallbladder: A case report. 61
23276760 2013
18
Different expression of S100A8 in malignant and benign gallbladder diseases. 61
22806545 2013
19
High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: differentiation between benignity and malignancy. 61
22576026 2012
20
Incidental gallbladder cancer during laparoscopic cholecystectomy: managing an unexpected finding. 61
22912553 2012
21
Proteomic-based analysis for identification of potential serum biomarkers in gallbladder cancer. 61
21687958 2011
22
Carcinoma gallbladder. 61
20639849 2010
23
[Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. 61
20168058 2010
24
[Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. 61
19844152 2009
25
Gallbladder adenoma with focal adenocarcinoma. 61
18717288 2008
26
A case of pyloric-type gallbladder adenoma. 61
18392262 2008
27
[A case of gallbladder adenoma with wide base]. 61
18176045 2008
28
Polypoid lesion of the gallbladder in childhood: case report and literature review. 61
18491679 2008
29
[Gallbladder adenoma with focal adenocarcinoma: a case report]. 61
17970176 2007
30
[Gallbladder polyps: correlation between ultrasonographic and histopathological findings]. 61
17186092 2006
31
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. 61
16447086 2006
32
[Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor]. 61
16944600 2006
33
Aberrant p53 expression and the development of gallbladder carcinoma and adenoma. 61
16568721 2006
34
Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma. 61
15968727 2005
35
A tubulopapillary adenoma of the gallbladder in a child of 3 years. 61
15015477 2004
36
[Surgical treatment of polypoid lesions of gallbladder]. 61
14692147 2003
37
Mutation and altered expression of beta-catenin during gallbladder carcinogenesis. 61
12023580 2002
38
Expression of the c-erb-B2 and p53 protein in gallbladder carcinomas. 61
11496329 2001
39
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. 61
11410326 2001
40
Beta-catenin mutations in biliary tract cancers: a population-based study in China. 54
11309300 2001
41
More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. 54
11196159 2001
42
CD44 variant overexpression in gallbladder carcinoma associated with tumor dedifferentiation. 61
11180088 2001
43
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts. 61
10613729 2000
44
Activation of telomerase and its diagnostic application in biopsy specimens from biliary tract neoplasms. 61
10326691 1999
45
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. 61
9923922 1999
46
Histological and genetic changes in malignant transformation of gallbladder adenoma. 61
10436806 1999
47
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts. 61
9356872 1997
48
[Gallbladder adenoma (pyloric gland type, intestinal type, proper epithelial type, papillary type, mucinous cystic type]. 61
8705486 1996
49
[A case of gallbladder adenoma based on cholesterol polyp]. 61
8089924 1994
50
[Adenoma of the gallbladder and its canceration: an analysis of 88 cases]. 61
7842974 1994
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Variations for Gallbladder Adenoma

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Cosmic variations for Gallbladder Adenoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM111893615 biliary tract,gallbladder,other,adenoma c.101C>T p.T34I 3:41224634-41224634 3
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Expression for Gallbladder Adenoma

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Search GEO for disease gene expression data for Gallbladder Adenoma.
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Pathways for Gallbladder Adenoma

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Pathways related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adipogenesis 1
11.25 RB1 PPARA CTNNB1
2
Transcription_P53 signaling pathway 22
11.06 RB1 CTNNB1 CDKN2A
3
Photodynamic therapy-induced AP-1 survival signaling. 1
11.03 RB1 CDKN2A
4
Glioblastoma Multiforme 63
10.84 RB1 CTNNB1 CDKN2A
5
Inhibition of Ribosome Biogenesis by p14(ARF) 63
10.6 RB1 CDKN2A
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GO Terms for Gallbladder Adenoma

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Cellular components related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microvillus membrane GO:0031528 8.62 PDPN CTNNB1

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.56 RB1 PPARA CTNNB1 CDKN2A
2 negative regulation of transcription, DNA-templated GO:0045892 9.46 RB1 PPARA CTNNB1 CDKN2A
3 positive regulation of epithelial to mesenchymal transition GO:0010718 9.43 PDPN CTNNB1
4 T cell differentiation GO:0030217 9.4 LFNG CTNNB1
5 androgen receptor signaling pathway GO:0030521 9.37 RB1 CTNNB1
6 negative regulation of apoptotic signaling pathway GO:2001234 9.32 RB1 CTNNB1
7 tissue homeostasis GO:0001894 8.96 RB1 CTNNB1
8 negative regulation of cell proliferation GO:0008285 8.92 RB1 PDPN CTNNB1 CDKN2A

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 androgen receptor binding GO:0050681 9.26 RB1 CTNNB1
2 transcription factor binding GO:0008134 9.26 RB1 PPARA CTNNB1 CDKN2A
3 chemokine binding GO:0019956 9.16 PDPN CCR6
4 disordered domain specific binding GO:0097718 8.8 RB1 CTNNB1 CDKN2A
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Sources for Gallbladder Adenoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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