MCID: GLL029
MIFTS: 28

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 56 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893
UMLS 74 C0238137

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A biliary tract benign neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to adenocarcinoma and adenoma. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include the gallbladder, and related phenotypes are behavior/neurological and immune system

Related Diseases for Gallbladder Adenoma

Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.7 CDKN2A CTNNB1 RB1
2 adenoma 10.3
3 tongue disease 10.2 CDKN2A CTNNB1
4 epstein-barr virus-associated gastric carcinoma 10.1 CDKN2A CTNNB1
5 nasopharyngeal disease 10.1 CDKN2A CTNNB1
6 periosteal chondrosarcoma 10.1 CDKN2A RB1
7 pharynx cancer 10.1 CDKN2A CTNNB1
8 suppressor of tumorigenicity 3 10.1 CDKN2A RB1
9 dedifferentiated liposarcoma 10.1 CDKN2A RB1
10 cervix disease 10.1 CDKN2A CTNNB1
11 ewing's family of tumors 10.1 CDKN2A RB1
12 cervical squamous cell carcinoma 10.1 CDKN2A CTNNB1
13 verrucous carcinoma 10.1 CDKN2A RB1
14 uterine anomalies 10.1 CDKN2A CTNNB1
15 cell type benign neoplasm 10.1 CDKN2A CTNNB1
16 retinal cancer 10.1 CDKN2A RB1
17 tongue cancer 10.1 CDKN2A CTNNB1
18 female reproductive system disease 10.1 CDKN2A CTNNB1
19 ocular cancer 10.1 CDKN2A RB1
20 reproductive system disease 10.1 CDKN2A CTNNB1
21 respiratory system cancer 10.0 CDKN2A CTNNB1
22 endometrial adenocarcinoma 10.0 CDKN2A CTNNB1
23 nervous system cancer 10.0 CDKN2A RB1
24 tongue squamous cell carcinoma 10.0 CDKN2A CTNNB1
25 gastrointestinal system cancer 9.9 CDKN2A CTNNB1
26 adamantinoma of long bones 9.9 CDKN2A CTNNB1 RB1
27 squamous cell carcinoma, head and neck 9.9 CDKN2A CTNNB1 RB1
28 squamous cell carcinoma 9.9 CDKN2A CTNNB1 RB1
29 gallbladder adenocarcinoma 9.8
30 cervical cancer 9.8 CDKN2A CTNNB1 RB1
31 endocrine gland cancer 9.8 CDKN2A CTNNB1
32 esophageal cancer 9.7 CDKN2A CTNNB1 RB1
33 endometrial cancer 9.6 CDKN2A CTNNB1 RB1

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

MGI Mouse Phenotypes related to Gallbladder Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.77 CDKN2A CSTB CTNNB1 PFN1 RB1
2 immune system MP:0005387 9.72 CDKN2A CSTB CTNNB1 PFN1 RB1
3 muscle MP:0005369 9.56 CDKN2A CSTB CTNNB1 RB1
4 no phenotypic analysis MP:0003012 9.46 CDKN2A CSTB CTNNB1 RB1
5 pigmentation MP:0001186 9.13 CDKN2A CTNNB1 RB1
6 vision/eye MP:0005391 9.02 CDKN2A CSTB CTNNB1 PFN1 RB1

Drugs & Therapeutics for Gallbladder Adenoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

20
The Gallbladder

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

# Title Authors Year
1
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. ( 26082060 )
2015
2
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. ( 25865694 )
2015
3
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. ( 25785101 )
2015
4
Gallbladder adenoma with focal adenocarcinoma. ( 18717288 )
2008
5
A case of pyloric-type gallbladder adenoma. ( 18392262 )
2008
6
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. ( 16447086 )
2006
7
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. ( 11410326 )
2001
8
Histological and genetic changes in malignant transformation of gallbladder adenoma. ( 10436806 )
1999

Variations for Gallbladder Adenoma

Cosmic variations for Gallbladder Adenoma:

9 (show all 19)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM521 KRAS biliary tract,gallbladder,other,adenoma c.35G>A p.G12D 12:25245350-25245350 0
2 COSM554 KRAS biliary tract,gallbladder,other,adenoma c.183A>C p.Q61H 12:25227341-25227341 0
3 COSM517 KRAS biliary tract,gallbladder,other,adenoma c.34G>A p.G12S 12:25245351-25245351 0
4 COSM516 KRAS biliary tract,gallbladder,other,adenoma c.34G>T p.G12C 12:25245351-25245351 0
5 COSM520 KRAS biliary tract,gallbladder,other,adenoma c.35G>T p.G12V 12:25245350-25245350 0
6 COSM553 KRAS biliary tract,gallbladder,other,adenoma c.182A>T p.Q61L 12:25227342-25227342 0
7 COSM552 KRAS biliary tract,gallbladder,other,adenoma c.182A>G p.Q61R 12:25227342-25227342 0
8 COSM5661 CTNNB1 biliary tract,gallbladder,other,adenoma c.94G>T p.D32Y 3:41224606-41224606 0
9 COSM5677 CTNNB1 biliary tract,gallbladder,other,adenoma c.98C>G p.S33C 3:41224610-41224610 0
10 COSM5667 CTNNB1 biliary tract,gallbladder,other,adenoma c.134C>T p.S45F 3:41224646-41224646 0
11 COSM5674 CTNNB1 biliary tract,gallbladder,other,adenoma c.104T>G p.I35S 3:41224616-41224616 0
12 COSM5662 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>T p.S37F 3:41224622-41224622 0
13 COSM5664 CTNNB1 biliary tract,gallbladder,other,adenoma c.121A>G p.T41A 3:41224633-41224633 0
14 COSM5670 CTNNB1 biliary tract,gallbladder,other,adenoma c.101G>T p.G34V 3:41224613-41224613 0
15 COSM5679 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>G p.S37C 3:41224622-41224622 0
16 COSM5672 CTNNB1 biliary tract,gallbladder,other,adenoma c.94G>A p.D32N 3:41224606-41224606 0
17 COSM5676 CTNNB1 biliary tract,gallbladder,other,adenoma c.122C>T p.T41I 3:41224634-41224634 0
18 COSM5669 CTNNB1 biliary tract,gallbladder,other,adenoma c.98C>T p.S33F 3:41224610-41224610 0
19 COSM5671 CTNNB1 biliary tract,gallbladder,other,adenoma c.101G>A p.G34E 3:41224613-41224613 0

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

GO Terms for Gallbladder Adenoma

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.58 CDKN2A CTNNB1 RB1
2 G1/S transition of mitotic cell cycle GO:0000082 9.37 CDKN2A RB1
3 negative regulation of protein kinase activity GO:0006469 9.32 CDKN2A RB1
4 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.26 CDKN2A PCNT
5 Ras protein signal transduction GO:0007265 9.16 CDKN2A RB1
6 negative regulation of cell proliferation GO:0008285 9.13 CDKN2A CTNNB1 RB1
7 androgen receptor signaling pathway GO:0030521 8.62 CTNNB1 RB1

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.43 CDKN2A CTNNB1 RB1
2 kinase binding GO:0019900 9.32 CTNNB1 RB1
3 RNA polymerase II activating transcription factor binding GO:0001102 9.16 CTNNB1 RB1
4 androgen receptor binding GO:0050681 8.96 CTNNB1 RB1
5 disordered domain specific binding GO:0097718 8.8 CDKN2A CTNNB1 RB1

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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