MCID: GLL029
MIFTS: 30

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893
UMLS 73 C0238137

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A biliary tract neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to adenocarcinoma and epstein-barr virus-associated gastric carcinoma. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Aldosterone synthesis and secretion and TNFR1 Pathway. Affiliated tissues include the gallbladder, and related phenotypes are Decreased cell migration and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance

Related Diseases for Gallbladder Adenoma

Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 28.6 CDKN2A CTNNB1 HRAS RB1
2 epstein-barr virus-associated gastric carcinoma 10.3 CDKN2A CTNNB1
3 spitz nevus 10.3 CDKN2A HRAS
4 melanomatosis 10.3 CDKN2A HRAS
5 nasal cavity adenocarcinoma 10.3 CDKN2A HRAS
6 meningeal melanomatosis 10.3 CDKN2A HRAS
7 dedifferentiated liposarcoma 10.3 CDKN2A RB1
8 suppressor of tumorigenicity 3 10.3 CDKN2A RB1
9 ewing's family of tumors 10.3 CDKN2A RB1
10 biliary tract neoplasm 10.3 CDKN2A HRAS
11 central nervous system melanocytic neoplasm 10.3 CDKN2A HRAS
12 bladder adenocarcinoma 10.3 CTNNB1 HRAS
13 skin squamous cell carcinoma 10.2 CDKN2A HRAS
14 cervical squamous cell carcinoma 10.2 CDKN2A CTNNB1
15 adenoma 10.2
16 penile cancer 10.2 CDKN2A HRAS
17 retinal cancer 10.2 CDKN2A RB1
18 sensory system cancer 10.2 CDKN2A RB1
19 integumentary system cancer 10.2 CDKN2A HRAS
20 intestinal benign neoplasm 10.2 CTNNB1 HRAS
21 ocular cancer 10.2 CDKN2A RB1
22 mesothelioma, malignant 10.1 CDKN2A CTNNB1
23 suppression of tumorigenicity 12 10.1 CTNNB1 HRAS
24 melanoma, cutaneous malignant 1 10.1 CDKN2A HRAS
25 colorectal adenoma 10.1 CTNNB1 HRAS
26 nervous system cancer 10.0 CDKN2A RB1
27 colorectal adenocarcinoma 10.0 CTNNB1 HRAS
28 differentiated thyroid carcinoma 10.0 CDKN2A HRAS
29 endocrine gland cancer 9.9 CDKN2A HRAS
30 periosteal chondrosarcoma 9.8 CDKN2A CTNNB1 RB1
31 bile duct cysts 9.8 HRAS PCNT
32 gastrointestinal system benign neoplasm 9.8 CDKN2A CTNNB1 HRAS
33 cell type benign neoplasm 9.8 CDKN2A CTNNB1 HRAS
34 female reproductive organ cancer 9.8 CDKN2A CTNNB1 HRAS
35 respiratory system cancer 9.8 CDKN2A CTNNB1 HRAS
36 cell type cancer 9.8 CDKN2A CTNNB1 HRAS
37 gastrointestinal system cancer 9.8 CDKN2A CTNNB1 HRAS
38 pancreas adenocarcinoma 9.8 CDKN2A CTNNB1 HRAS
39 skin melanoma 9.8 CDKN2A CTNNB1 HRAS
40 adamantinoma of long bones 9.8 CDKN2A CTNNB1 RB1
41 lung cancer susceptibility 3 9.7 CDKN2A CTNNB1 HRAS
42 gastric adenocarcinoma 9.7 CDKN2A CTNNB1 HRAS
43 cholangiocarcinoma 9.7 CDKN2A CTNNB1 HRAS
44 nasopharyngeal carcinoma 9.7 CDKN2A CTNNB1 HRAS
45 gallbladder adenocarcinoma 9.7
46 bladder urothelial carcinoma 9.7 CTNNB1 HRAS RB1
47 uterine carcinosarcoma 9.7 CTNNB1 HRAS
48 glioblastoma 9.6 CDKN2A HRAS RB1
49 tongue squamous cell carcinoma 9.6 CDKN2A CTNNB1
50 squamous cell carcinoma, head and neck 9.2 CDKN2A CTNNB1 HRAS RB1

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

GenomeRNAi Phenotypes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.33 CTNNB1 HRAS PFN1
2 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.13 CTNNB1 HRAS PFN1
3 Increased cell migration GR00055-A-3 8.8 CTNNB1 HRAS PFN1

MGI Mouse Phenotypes related to Gallbladder Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 HRAS PFN1 RB1 CDKN2A CTNNB1
2 digestive/alimentary MP:0005381 9.67 HRAS RB1 CDKN2A CTNNB1
3 neoplasm MP:0002006 9.62 HRAS RB1 CDKN2A CTNNB1
4 no phenotypic analysis MP:0003012 9.56 HRAS RB1 CDKN2A CTNNB1
5 pigmentation MP:0001186 9.33 RB1 CDKN2A CTNNB1
6 respiratory system MP:0005388 9.26 HRAS RB1 CDKN2A CTNNB1
7 skeleton MP:0005390 9.02 PFN1 RB1 CDKN2A CTNNB1 HRAS

Drugs & Therapeutics for Gallbladder Adenoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

19
The Gallbladder

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

(show all 11)
# Title Authors Year
1
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. ( 26082060 )
2015
2
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. ( 25865694 )
2015
3
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. ( 25785101 )
2015
4
Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. ( 21307665 )
2011
5
Gallbladder adenoma with focal adenocarcinoma. ( 18717288 )
2008
6
A case of pyloric-type gallbladder adenoma. ( 18392262 )
2008
7
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. ( 16447086 )
2006
8
More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. ( 11196159 )
2001
9
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. ( 11410326 )
2001
10
Histological and genetic changes in malignant transformation of gallbladder adenoma. ( 10436806 )
1999
11
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. ( 9923922 )
1999

Variations for Gallbladder Adenoma

Cosmic variations for Gallbladder Adenoma:

9
(show all 15)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM521 KRAS biliary tract,gallbladder,other,adenoma c.35G>A p.G12D 12:25245350-25245350 6
2 COSM554 KRAS biliary tract,gallbladder,other,adenoma c.183A>C p.Q61H 12:25227341-25227341 6
3 COSM517 KRAS biliary tract,gallbladder,other,adenoma c.34G>A p.G12S 12:25245351-25245351 6
4 COSM520 KRAS biliary tract,gallbladder,other,adenoma c.35G>T p.G12V 12:25245350-25245350 6
5 COSM516 KRAS biliary tract,gallbladder,other,adenoma c.34G>T p.G12C 12:25245351-25245351 6
6 COSM553 KRAS biliary tract,gallbladder,other,adenoma c.182A>T p.Q61L 12:25227342-25227342 6
7 COSM552 KRAS biliary tract,gallbladder,other,adenoma c.182A>G p.Q61R 12:25227342-25227342 6
8 COSM5667 CTNNB1 biliary tract,gallbladder,other,adenoma c.134C>T p.S45F 3:41224646-41224646 6
9 COSM5662 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>T p.S37F 3:41224622-41224622 6
10 COSM5670 CTNNB1 biliary tract,gallbladder,other,adenoma c.101G>T p.G34V 3:41224613-41224613 6
11 COSM5679 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>G p.S37C 3:41224622-41224622 6
12 COSM5672 CTNNB1 biliary tract,gallbladder,other,adenoma c.94G>A p.D32N 3:41224606-41224606 6
13 COSM5676 CTNNB1 biliary tract,gallbladder,other,adenoma c.122C>T p.T41I 3:41224634-41224634 6
14 COSM5664 CTNNB1 biliary tract,gallbladder,other,adenoma c.121A>G p.T41A 3:41224633-41224633 6
15 COSM5677 CTNNB1 biliary tract,gallbladder,other,adenoma c.98C>G p.S33C 3:41224610-41224610 6

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

Pathways related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 CDKN2A CTNNB1 HRAS RB1
2
Show member pathways
12.6 CTNNB1 HRAS RB1
3
Show member pathways
12.48 CDKN2A HRAS RB1
4
Show member pathways
12.48 CDKN2A CTNNB1 HRAS RB1
5
Show member pathways
12.44 CTNNB1 HRAS PFN1
6 12.43 CDKN2A CTNNB1 HRAS RB1
7
Show member pathways
12.34 CTNNB1 HRAS PFN1
8
Show member pathways
12.29 CDKN2A CTNNB1 HRAS RB1
9
Show member pathways
12.27 CTNNB1 HRAS RB1
10
Show member pathways
12.23 CTNNB1 HRAS RB1
11
Show member pathways
12.13 CTNNB1 HRAS RB1
12 11.97 CDKN2A HRAS RB1
13 11.84 CDKN2A HRAS RB1
14 11.74 CDKN2A CTNNB1 RB1
15 11.66 CDKN2A CTNNB1 HRAS RB1
16 11.6 CDKN2A CTNNB1 HRAS
17 11.47 CTNNB1 PFN1
18 11.46 HRAS RB1
19 11.46 CDKN2A HRAS RB1
20 11.4 CTNNB1 PFN1
21 11.37 CTNNB1 HRAS
22
Show member pathways
11.31 HRAS RB1
23 11.3 CDKN2A RB1
24 11.27 HRAS RB1
25 11.2 CDKN2A HRAS RB1
26 11.03 CTNNB1 HRAS
27 10.97 CDKN2A CTNNB1 HRAS RB1
28 10.9 HRAS RB1
29 10.87 CDKN2A RB1

GO Terms for Gallbladder Adenoma

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.73 CDKN2A CTNNB1 HRAS RB1
2 positive regulation of gene expression GO:0010628 9.65 CDKN2A CTNNB1 HRAS
3 negative regulation of gene expression GO:0010629 9.54 CTNNB1 HRAS RB1
4 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.49 CDKN2A PCNT
5 androgen receptor signaling pathway GO:0030521 9.46 CTNNB1 RB1
6 mitotic cell cycle checkpoint GO:0007093 9.4 HRAS RB1
7 cell cycle arrest GO:0007050 9.33 CDKN2A HRAS RB1
8 cellular senescence GO:0090398 9.32 CDKN2A HRAS
9 positive regulation of ruffle assembly GO:1900029 9.26 HRAS PFN1
10 negative regulation of cell proliferation GO:0008285 9.26 CDKN2A CTNNB1 HRAS RB1
11 Ras protein signal transduction GO:0007265 8.8 CDKN2A HRAS RB1

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.33 CDKN2A CTNNB1 RB1
2 RNA polymerase II activating transcription factor binding GO:0001102 9.26 CTNNB1 RB1
3 androgen receptor binding GO:0050681 8.96 CTNNB1 RB1
4 disordered domain specific binding GO:0097718 8.8 CDKN2A CTNNB1 RB1

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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