MCID: GLL029
MIFTS: 34

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 55 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893
UMLS 72 C0238137

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A biliary tract benign neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to colorectal adenoma and adenocarcinoma. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Human cytomegalovirus infection and Endometrial cancer. Affiliated tissues include pancreas, endothelial and gallbladder, and related phenotypes are Decreased cell migration and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance

Related Diseases for Gallbladder Adenoma

Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 colorectal adenoma 29.9 HRAS CTNNB1
2 adenocarcinoma 29.4 RB1 HRAS CTNNB1 CDKN2A
3 adenoma 10.5
4 tongue disease 10.3 CTNNB1 CDKN2A
5 epstein-barr virus-associated gastric carcinoma 10.3 CTNNB1 CDKN2A
6 spitz nevus 10.3 HRAS CDKN2A
7 melanomatosis 10.3 HRAS CDKN2A
8 nasal cavity adenocarcinoma 10.3 HRAS CDKN2A
9 periosteal chondrosarcoma 10.3 RB1 CDKN2A
10 meningeal melanomatosis 10.2 HRAS CDKN2A
11 nasopharyngeal disease 10.2 CTNNB1 CDKN2A
12 suppressor of tumorigenicity 3 10.2 RB1 CDKN2A
13 dedifferentiated liposarcoma 10.2 RB1 CDKN2A
14 ewing's family of tumors 10.2 RB1 CDKN2A
15 verrucous carcinoma 10.2 RB1 CDKN2A
16 pharynx cancer 10.2 CTNNB1 CDKN2A
17 cervix disease 10.2 CTNNB1 CDKN2A
18 central nervous system melanocytic neoplasm 10.2 HRAS CDKN2A
19 bladder adenocarcinoma 10.2 HRAS CTNNB1
20 cervical squamous cell carcinoma 10.2 CTNNB1 CDKN2A
21 skin squamous cell carcinoma 10.2 HRAS CDKN2A
22 retinal cancer 10.2 RB1 CDKN2A
23 gastrointestinal system benign neoplasm 10.2 HRAS CTNNB1
24 uterine anomalies 10.2 CTNNB1 CDKN2A
25 intestinal benign neoplasm 10.2 HRAS CTNNB1
26 gallbladder cancer 10.1
27 tongue cancer 10.1 CTNNB1 CDKN2A
28 ocular cancer 10.1 RB1 CDKN2A
29 female reproductive system disease 10.1 CTNNB1 CDKN2A
30 bile duct cysts 10.1 PCNT HRAS
31 reproductive system disease 10.1 CTNNB1 CDKN2A
32 carcinosarcoma 10.1 HRAS CTNNB1
33 colonic disease 10.0 HRAS CTNNB1
34 colorectal adenocarcinoma 10.0 HRAS CTNNB1
35 gallbladder disease 10.0
36 in situ carcinoma 10.0
37 endometrial adenocarcinoma 10.0 CTNNB1 CDKN2A
38 nervous system cancer 10.0 RB1 CDKN2A
39 cell type benign neoplasm 9.9 HRAS CTNNB1 CDKN2A
40 respiratory system cancer 9.9 HRAS CTNNB1 CDKN2A
41 gastrointestinal system cancer 9.9 HRAS CTNNB1 CDKN2A
42 endocrine gland cancer 9.9 HRAS CTNNB1 CDKN2A
43 gastrointestinal system disease 9.9 HRAS CTNNB1 CDKN2A
44 gallbladder disease 1 9.8
45 familial adenomatous polyposis 9.8
46 villous adenoma 9.8
47 cholecystitis 9.8
48 gallbladder adenocarcinoma 9.8
49 melanoma, cutaneous malignant 1 9.8 HRAS CTNNB1 CDKN2A
50 adamantinoma of long bones 9.8 RB1 CTNNB1 CDKN2A

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

GenomeRNAi Phenotypes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.33 CTNNB1 HRAS PFN1
2 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.13 CTNNB1 HRAS PFN1
3 Increased cell migration GR00055-A-3 8.8 CTNNB1 HRAS PFN1

MGI Mouse Phenotypes related to Gallbladder Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 CDKN2A CTNNB1 HRAS PFN1 RB1
2 digestive/alimentary MP:0005381 9.67 CDKN2A CTNNB1 HRAS RB1
3 neoplasm MP:0002006 9.62 CDKN2A CTNNB1 HRAS RB1
4 no phenotypic analysis MP:0003012 9.56 CDKN2A CTNNB1 HRAS RB1
5 pigmentation MP:0001186 9.33 CDKN2A CTNNB1 RB1
6 respiratory system MP:0005388 9.26 CDKN2A CTNNB1 HRAS RB1
7 skeleton MP:0005390 9.02 CDKN2A CTNNB1 HRAS PFN1 RB1

Drugs & Therapeutics for Gallbladder Adenoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Prospective Cohort Study of Risk Factors for Gallbladder Cancer Not yet recruiting NCT03762837

Search NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

MalaCards organs/tissues related to Gallbladder Adenoma:

41
Pancreas, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

19
Gallbladder

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

(show top 50) (show all 52)
# Title Authors PMID Year
1
Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. 9 38
20422865 2010
2
Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. 9 38
15655836 2005
3
Biotin-rich, optically clear nuclei express estrogen receptor-beta: tumors with morules may develop under the influence of estrogen and aberrant beta-catenin expression. 9 38
15257551 2004
4
Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. 9 38
11584965 2001
5
Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion. 38
29456413 2018
6
KrasG12D upregulates Notch signaling to induce gallbladder tumorigenesis in mice. 38
29142904 2017
7
Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite. 38
28274810 2017
8
Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder. 38
26643927 2016
9
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. 38
26082060 2015
10
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. 38
25865694 2015
11
Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance. 38
25973087 2015
12
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. 38
25785101 2015
13
Managing the incidentally detected gallbladder cancer: algorithms and controversies. 38
25182380 2014
14
Unicryptal gallbladder adenomas in a patient with Gardner's syndrome. 38
23787021 2013
15
Large villous adenoma of gallbladder: A case report. 38
23276760 2013
16
Different expression of S100A8 in malignant and benign gallbladder diseases. 38
22806545 2013
17
High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: differentiation between benignity and malignancy. 38
22576026 2012
18
Incidental gallbladder cancer during laparoscopic cholecystectomy: managing an unexpected finding. 38
22912553 2012
19
Proteomic-based analysis for identification of potential serum biomarkers in gallbladder cancer. 38
21687958 2011
20
Carcinoma gallbladder. 38
20639849 2010
21
[Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. 38
20168058 2010
22
[Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. 38
19844152 2009
23
Gallbladder adenoma with focal adenocarcinoma. 38
18717288 2008
24
A case of pyloric-type gallbladder adenoma. 38
18392262 2008
25
Polypoid lesion of the gallbladder in childhood: case report and literature review. 38
18491679 2008
26
[A case of gallbladder adenoma with wide base]. 38
18176045 2008
27
[Gallbladder adenoma with focal adenocarcinoma: a case report]. 38
17970176 2007
28
[Gallbladder polyps: correlation between ultrasonographic and histopathological findings]. 38
17186092 2006
29
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. 38
16447086 2006
30
[Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor]. 38
16944600 2006
31
Aberrant p53 expression and the development of gallbladder carcinoma and adenoma. 38
16568721 2006
32
Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma. 38
15968727 2005
33
A tubulopapillary adenoma of the gallbladder in a child of 3 years. 38
15015477 2004
34
[Surgical treatment of polypoid lesions of gallbladder]. 38
14692147 2003
35
Mutation and altered expression of beta-catenin during gallbladder carcinogenesis. 38
12023580 2002
36
Expression of the c-erb-B2 and p53 protein in gallbladder carcinomas. 38
11496329 2001
37
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. 38
11410326 2001
38
Beta-catenin mutations in biliary tract cancers: a population-based study in China. 9
11309300 2001
39
More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. 9
11196159 2001
40
CD44 variant overexpression in gallbladder carcinoma associated with tumor dedifferentiation. 38
11180088 2001
41
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts. 38
10613729 2000
42
Activation of telomerase and its diagnostic application in biopsy specimens from biliary tract neoplasms. 38
10326691 1999
43
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. 38
9923922 1999
44
Histological and genetic changes in malignant transformation of gallbladder adenoma. 38
10436806 1999
45
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts. 38
9356872 1997
46
[Gallbladder adenoma (pyloric gland type, intestinal type, proper epithelial type, papillary type, mucinous cystic type]. 38
8705486 1996
47
[A case of gallbladder adenoma based on cholesterol polyp]. 38
8089924 1994
48
[Adenoma of the gallbladder and its canceration: an analysis of 88 cases]. 38
7842974 1994
49
Familial occurrence of anomalous pancreaticobiliary duct union associated with gallbladder neoplasms. 38
2916531 1989
50
[Gallbladder adenoma with carcinoma in situ. Apropos of a case]. 38
3058960 1988

Variations for Gallbladder Adenoma

Cosmic variations for Gallbladder Adenoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM5676 CTNNB1 biliary tract,gallbladder,other,adenoma c.122C>T p.T41I 3:41224634-41224634 3

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

Pathways related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 RB1 HRAS CTNNB1 CDKN2A
2
Show member pathways
12.48 RB1 HRAS CTNNB1 CDKN2A
3
Show member pathways
12.44 PFN1 HRAS CTNNB1
4 12.43 RB1 HRAS CTNNB1 CDKN2A
5
Show member pathways
12.4 RB1 HRAS CDKN2A
6
Show member pathways
12.33 PFN1 HRAS CTNNB1
7
Show member pathways
12.29 RB1 HRAS CTNNB1 CDKN2A
8 11.99 RB1 HRAS CDKN2A
9
Show member pathways
11.92 RB1 HRAS CTNNB1
10 11.84 RB1 HRAS CDKN2A
11 11.74 RB1 CTNNB1 CDKN2A
12 11.6 HRAS CTNNB1 CDKN2A
13 11.6 RB1 HRAS CTNNB1 CDKN2A
14 11.46 RB1 HRAS
15 11.46 PFN1 CTNNB1
16 11.46 RB1 HRAS CDKN2A
17 11.4 RB1 CTNNB1 CDKN2A
18 11.39 PFN1 CTNNB1
19 11.37 HRAS CTNNB1
20
Show member pathways
11.31 RB1 HRAS
21 11.29 RB1 CDKN2A
22 11.26 RB1 HRAS
23 11.2 RB1 HRAS CDKN2A
24 11.04 HRAS CTNNB1
25 10.97 RB1 HRAS CTNNB1 CDKN2A
26 10.91 RB1 HRAS
27 10.87 RB1 CDKN2A

GO Terms for Gallbladder Adenoma

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.76 RB1 HRAS CTNNB1 CDKN2A
2 positive regulation of gene expression GO:0010628 9.65 HRAS CTNNB1 CDKN2A
3 negative regulation of gene expression GO:0010629 9.54 RB1 HRAS CTNNB1
4 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.51 PCNT CDKN2A
5 negative regulation of protein kinase activity GO:0006469 9.49 RB1 CDKN2A
6 androgen receptor signaling pathway GO:0030521 9.43 RB1 CTNNB1
7 mitotic cell cycle checkpoint GO:0007093 9.4 RB1 HRAS
8 cell cycle arrest GO:0007050 9.33 RB1 HRAS CDKN2A
9 cellular senescence GO:0090398 9.32 HRAS CDKN2A
10 positive regulation of ruffle assembly GO:1900029 9.26 PFN1 HRAS
11 negative regulation of cell proliferation GO:0008285 9.26 RB1 HRAS CTNNB1 CDKN2A
12 Ras protein signal transduction GO:0007265 8.8 RB1 HRAS CDKN2A

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.43 RB1 CTNNB1 CDKN2A
2 RNA polymerase II activating transcription factor binding GO:0001102 9.16 RB1 CTNNB1
3 androgen receptor binding GO:0050681 8.96 RB1 CTNNB1
4 disordered domain specific binding GO:0097718 8.8 RB1 CTNNB1 CDKN2A

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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