MCID: GLL029
MIFTS: 30

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 54 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893
UMLS 71 C0238137

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A gallbladder benign neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to adenoma and gallbladder cancer. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Adipogenesis and Transcription_P53 signaling pathway. Affiliated tissues include gallbladder, pancreas and thyroid, and related phenotypes are muscle and respiratory system

Related Diseases for Gallbladder Adenoma

Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.8 KRT7 CTNNB1 CDKN2A
2 gallbladder cancer 30.0 KRT7 CTNNB1 CDKN2A
3 in situ carcinoma 30.0 PDPN CTNNB1 CDKN2A
4 adenocarcinoma 29.8 RB1 KRT7 CTNNB1 CDKN2A
5 gallbladder disease 29.7 PDPN KRT7 CTNNB1
6 vulvar intraepithelial neoplasia 10.4 CTNNB1 CDKN2A
7 atypical polypoid adenomyoma 10.3 CTNNB1 CDKN2A
8 urinary bladder inverted papilloma 10.3 RB1 CDKN2A
9 bone squamous cell carcinoma 10.3 CTNNB1 CDKN2A
10 epstein-barr virus-associated gastric carcinoma 10.3 CTNNB1 CDKN2A
11 suppressor of tumorigenicity 3 10.3 RB1 CDKN2A
12 familial retinoblastoma 10.3 RB1 CDKN2A
13 cervical basaloid squamous cell carcinoma 10.2 KRT7 CDKN2A
14 basaloid squamous cell carcinoma 10.2 KRT7 CDKN2A
15 inverted papilloma 10.2 KRT7 CDKN2A
16 inverted transitional papilloma 10.2 KRT7 CDKN2A
17 anal canal paget's disease 10.2 KRT7 CDKN2A
18 uterus carcinoma in situ 10.2 RB1 CDKN2A
19 cervical adenoid cystic carcinoma 10.2 KRT7 CDKN2A
20 atrophic vulva 10.2 KRT7 CDKN2A
21 cervix uteri carcinoma in situ 10.2 RB1 CDKN2A
22 ovarian seromucinous carcinoma 10.2 KRT7 CDKN2A
23 vaginal tubulovillous adenoma 10.2 KRT7 CDKN2A
24 penile benign neoplasm 10.2 PDPN CDKN2A
25 atypical neurofibroma 10.2 PDPN CDKN2A
26 papillary squamous carcinoma 10.2 KRT7 CDKN2A
27 supraglottis cancer 10.2 PDPN CDKN2A
28 gliomatosis cerebri 10.2 RB1 CDKN2A
29 keratinizing squamous cell carcinoma 10.2 KRT7 CDKN2A
30 glandular cystitis 10.2 KRT7 CTNNB1
31 bile duct adenoma 10.2 KRT7 CDKN2A
32 bladder clear cell adenocarcinoma 10.2 KRT7 CDKN2A
33 vaginal adenoma 10.2 KRT7 CTNNB1
34 malignant spiradenoma 10.2 KRT7 CDKN2A
35 vaginal benign neoplasm 10.2 KRT7 CTNNB1
36 vaginal cancer 10.2 KRT7 CDKN2A
37 biliary tract benign neoplasm 10.2 NIPSNAP2 KRT7
38 papillary craniopharyngioma 10.2 KRT7 CTNNB1
39 borst-jadassohn intraepidermal carcinoma 10.2 KRT7 CDKN2A
40 bladder adenocarcinoma 10.2 KRT7 CTNNB1
41 laryngeal benign neoplasm 10.2 PDPN CDKN2A
42 vulvar disease 10.2 KRT7 CDKN2A
43 retroperitoneum carcinoma 10.2 KRT7 CDKN2A
44 nasal cavity cancer 10.1 KRT7 CDKN2A
45 pulmonary sclerosing hemangioma 10.1 KRT7 CTNNB1
46 sclerosing hemangioma 10.1 KRT7 CTNNB1
47 esophagus adenocarcinoma 10.1 CTNNB1 CDKN2A
48 peritoneum cancer 10.1 KRT7 CDKN2A
49 anus cancer 10.1 KRT7 CDKN2A
50 conjunctival squamous cell carcinoma 10.1 RB1 PDPN

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

MGI Mouse Phenotypes related to Gallbladder Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.35 CDKN2A CTNNB1 PDPN PPARA RB1
2 respiratory system MP:0005388 9.02 CDKN2A CTNNB1 LFNG PDPN RB1

Drugs & Therapeutics for Gallbladder Adenoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Prospective Cohort Study of Risk Factors for Gallbladder Cancer Not yet recruiting NCT03762837

Search NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

19
Gallbladder

MalaCards organs/tissues related to Gallbladder Adenoma:

40
Pancreas, Thyroid, Endothelial

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. 54 61
20422865 2010
2
Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. 61 54
15655836 2005
3
Biotin-rich, optically clear nuclei express estrogen receptor-beta: tumors with morules may develop under the influence of estrogen and aberrant beta-catenin expression. 54 61
15257551 2004
4
Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. 61 54
11584965 2001
5
Ectopic thyroid in the gallbladder accompanied with gallbladder adenoma: A case report. 61
31852107 2019
6
Amputation neuroma derived from a remnant cystic duct 30 years after cholecystectomy: A case report. 61
31671354 2019
7
Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion. 61
29456413 2018
8
KrasG12D upregulates Notch signaling to induce gallbladder tumorigenesis in mice. 61
29142904 2017
9
Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite. 61
28274810 2017
10
Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder. 61
26643927 2016
11
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. 61
26082060 2015
12
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. 61
25865694 2015
13
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. 61
25785101 2015
14
Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance. 61
25973087 2015
15
Managing the incidentally detected gallbladder cancer: algorithms and controversies. 61
25182380 2014
16
Unicryptal gallbladder adenomas in a patient with Gardner's syndrome. 61
23787021 2013
17
Large villous adenoma of gallbladder: A case report. 61
23276760 2013
18
Different expression of S100A8 in malignant and benign gallbladder diseases. 61
22806545 2013
19
High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: differentiation between benignity and malignancy. 61
22576026 2012
20
Incidental gallbladder cancer during laparoscopic cholecystectomy: managing an unexpected finding. 61
22912553 2012
21
Proteomic-based analysis for identification of potential serum biomarkers in gallbladder cancer. 61
21687958 2011
22
Carcinoma gallbladder. 61
20639849 2010
23
[Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. 61
20168058 2010
24
[Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. 61
19844152 2009
25
Gallbladder adenoma with focal adenocarcinoma. 61
18717288 2008
26
A case of pyloric-type gallbladder adenoma. 61
18392262 2008
27
[A case of gallbladder adenoma with wide base]. 61
18176045 2008
28
Polypoid lesion of the gallbladder in childhood: case report and literature review. 61
18491679 2008
29
[Gallbladder adenoma with focal adenocarcinoma: a case report]. 61
17970176 2007
30
[Gallbladder polyps: correlation between ultrasonographic and histopathological findings]. 61
17186092 2006
31
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. 61
16447086 2006
32
[Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor]. 61
16944600 2006
33
Aberrant p53 expression and the development of gallbladder carcinoma and adenoma. 61
16568721 2006
34
Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma. 61
15968727 2005
35
A tubulopapillary adenoma of the gallbladder in a child of 3 years. 61
15015477 2004
36
[Surgical treatment of polypoid lesions of gallbladder]. 61
14692147 2003
37
Mutation and altered expression of beta-catenin during gallbladder carcinogenesis. 61
12023580 2002
38
Expression of the c-erb-B2 and p53 protein in gallbladder carcinomas. 61
11496329 2001
39
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. 61
11410326 2001
40
Beta-catenin mutations in biliary tract cancers: a population-based study in China. 54
11309300 2001
41
CD44 variant overexpression in gallbladder carcinoma associated with tumor dedifferentiation. 61
11180088 2001
42
More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. 54
11196159 2001
43
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts. 61
10613729 2000
44
Activation of telomerase and its diagnostic application in biopsy specimens from biliary tract neoplasms. 61
10326691 1999
45
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. 61
9923922 1999
46
Histological and genetic changes in malignant transformation of gallbladder adenoma. 61
10436806 1999
47
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts. 61
9356872 1997
48
[Gallbladder adenoma (pyloric gland type, intestinal type, proper epithelial type, papillary type, mucinous cystic type]. 61
8705486 1996
49
[A case of gallbladder adenoma based on cholesterol polyp]. 61
8089924 1994
50
[Adenoma of the gallbladder and its canceration: an analysis of 88 cases]. 61
7842974 1994

Variations for Gallbladder Adenoma

Cosmic variations for Gallbladder Adenoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM111893615 biliary tract,gallbladder,other,adenoma c.101C>T p.T34I 3:41224634-41224634 0

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

Pathways related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.25 RB1 PPARA CTNNB1
2 11.06 RB1 CTNNB1 CDKN2A
3 10.84 RB1 CTNNB1 CDKN2A
4 10.6 RB1 CDKN2A

GO Terms for Gallbladder Adenoma

Cellular components related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microvillus membrane GO:0031528 8.62 PDPN CTNNB1

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.56 RB1 PPARA CTNNB1 CDKN2A
2 negative regulation of transcription, DNA-templated GO:0045892 9.46 RB1 PPARA CTNNB1 CDKN2A
3 positive regulation of epithelial to mesenchymal transition GO:0010718 9.43 PDPN CTNNB1
4 T cell differentiation GO:0030217 9.4 LFNG CTNNB1
5 androgen receptor signaling pathway GO:0030521 9.37 RB1 CTNNB1
6 negative regulation of apoptotic signaling pathway GO:2001234 9.32 RB1 CTNNB1
7 tissue homeostasis GO:0001894 8.96 RB1 CTNNB1
8 negative regulation of cell proliferation GO:0008285 8.92 RB1 PDPN CTNNB1 CDKN2A

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.26 RB1 PPARA CTNNB1 CDKN2A
2 androgen receptor binding GO:0050681 9.16 RB1 CTNNB1
3 disordered domain specific binding GO:0097718 8.8 RB1 CTNNB1 CDKN2A

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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