MCID: GLL050
MIFTS: 22

Gallbladder Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases, Liver diseases, Rare diseases
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Aliases & Classifications for Gallbladder Carcinoma in Situ

MalaCards integrated aliases for Gallbladder Carcinoma in Situ:

Name: Gallbladder Carcinoma in Situ 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0050612

Summaries for Gallbladder Carcinoma in Situ

Disease Ontology: 11 An in situ carcinoma located in the surface epithelium of the gallbladder that most commonly develops into adenocarcinoma.

MalaCards based summary: Gallbladder Carcinoma in Situ is related to gallbladder cancer and colloid carcinoma of the pancreas. An important gene associated with Gallbladder Carcinoma in Situ is MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Metabolism of proteins and Diseases of glycosylation. Affiliated tissues include surface epithelium of the gallbladder, and related phenotypes are neoplasm and digestive/alimentary

Related Diseases for Gallbladder Carcinoma in Situ

Diseases in the Gallbladder Cancer family:

Gallbladder Carcinoma in Situ

Diseases related to Gallbladder Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 gallbladder cancer 28.5 TP53 MUC6 MUC5AC MUC1 CEACAM5 CDX2
2 colloid carcinoma of the pancreas 10.2 MUC5AC CDX2
3 anal gland adenocarcinoma 10.2 MUC5AC CDX2
4 anus adenocarcinoma 10.2 MUC5AC CDX2
5 anal canal adenocarcinoma 10.2 MUC5AC CDX2
6 mucoepidermoid carcinoma 10.2 MUC5AC MUC1
7 intrahepatic biliary papillomatosis 10.2 MUC5AC MUC1
8 bile reflux 10.1 MUC5AC CDX2
9 gallbladder signet ring cell adenocarcinoma 10.1 MUC1 CDX2
10 lynch syndrome 8 10.1 MUC5AC MUC1
11 medullary colon carcinoma 10.1 MUC1 CDX2
12 atypical polypoid adenomyoma 10.1 MME CDX2
13 breast hemangioma 10.1 TP53 CDX2
14 large cell carcinoma with rhabdoid phenotype 10.1 TP53 MUC5AC
15 adenomyoma 10.1 MUC1 MME
16 epididymis adenocarcinoma 10.1 MME CDX2
17 epididymis cancer 10.1 MME CDX2
18 clear cell adenocarcinoma 10.1 TP53 MME
19 uterus perivascular epithelioid cell tumor 10.1 MUC1 MME
20 chronic cystitis 10.1 TP53 CDX2
21 dry eye syndrome 10.1 MUC5AC MUC1
22 gastric tubular adenocarcinoma 10.1 MUC6 MUC5AC
23 gastric teratoma 10.1 MUC6 MUC5AC
24 vaginal carcinosarcoma 10.1 TP53 MME
25 sclerosing hemangioma 10.0 TP53 MUC1
26 breast metaplastic carcinoma 10.0 TP53 MME
27 pulmonary sclerosing hemangioma 10.0 TP53 MUC1
28 cystadenofibroma 10.0 TP53 MME
29 colon adenoma 10.0 TP53 CDX2
30 cervical adenosarcoma 10.0 TP53 MME
31 adenosarcoma 10.0 TP53 MME
32 breast malignant phyllodes tumor 10.0 TP53 MME
33 esophagus adenocarcinoma 10.0 TP53 CDX2
34 papilloma of choroid plexus 10.0 TP53 MUC1
35 intraductal breast benign neoplasm 10.0 TP53 MME
36 breast lobular carcinoma 10.0 TP53 MUC1
37 vaginal cancer 10.0 TP53 MME
38 pulmonary blastoma 10.0 TP53 MUC1
39 chronic lymphocytic leukemia/small lymphocytic lymphoma 10.0 TP53 MME
40 spindle cell sarcoma 10.0 TP53 MUC1
41 cervical polyp 10.0 MUC6 MME
42 rhabdoid cancer 10.0 TP53 MUC1
43 mesenchymal cell neoplasm 10.0 TP53 MME
44 connective tissue benign neoplasm 10.0 TP53 MME
45 laryngeal mucoepidermoid carcinoma 10.0 CEACAM5 CDX2
46 ureter adenocarcinoma 10.0 CEACAM5 CDX2
47 thymus adenocarcinoma 10.0 CEACAM5 CDX2
48 vaginal tubulovillous adenoma 10.0 CEACAM5 CDX2
49 vulva adenocarcinoma 10.0 CEACAM5 CDX2
50 ovarian cyst 10.0 MUC1 CEACAM5

Graphical network of the top 20 diseases related to Gallbladder Carcinoma in Situ:



Diseases related to Gallbladder Carcinoma in Situ

Symptoms & Phenotypes for Gallbladder Carcinoma in Situ

MGI Mouse Phenotypes related to Gallbladder Carcinoma in Situ:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 CDX2 CEACAM5 MUC1 TP53
2 digestive/alimentary MP:0005381 9.02 CDX2 CEACAM5 MUC1 MUC5AC TP53

Drugs & Therapeutics for Gallbladder Carcinoma in Situ

Search Clinical Trials, NIH Clinical Center for Gallbladder Carcinoma in Situ

Genetic Tests for Gallbladder Carcinoma in Situ

Anatomical Context for Gallbladder Carcinoma in Situ

Organs/tissues related to Gallbladder Carcinoma in Situ:

FMA: Surface Epithelium Of The Gallbladder

Publications for Gallbladder Carcinoma in Situ

Articles related to Gallbladder Carcinoma in Situ:

# Title Authors PMID Year
1
Routine histopathology of gallbladder after elective cholecystectomy for gallstones: waste of resources or a justified act? 62
23834815 2013
2
Implant metastasis of gallbladder carcinoma in situ in a cholecystectomy scar: a case report. 62
8356516 1993

Variations for Gallbladder Carcinoma in Situ

Expression for Gallbladder Carcinoma in Situ

Search GEO for disease gene expression data for Gallbladder Carcinoma in Situ.

Pathways for Gallbladder Carcinoma in Situ

Pathways related to Gallbladder Carcinoma in Situ according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 TP53 MUC6 MUC5AC MUC1 MME CEACAM5
2
Show member pathways
12.23 MUC6 MUC5AC MUC1
3
Show member pathways
11.9 MUC6 MUC5AC MUC1
4
Show member pathways
11.8 MUC6 MUC5AC MUC1
5
Show member pathways
11.49 MUC6 MUC5AC MUC1
6
Show member pathways
10.97 MUC6 MUC5AC MUC1
7 10.96 MUC1 CEACAM5

GO Terms for Gallbladder Carcinoma in Situ

Cellular components related to Gallbladder Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.1 MUC6 MUC5AC MUC1

Biological processes related to Gallbladder Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.56 TP53 MUC1
2 replicative senescence GO:0090399 9.46 TP53 MME
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.26 TP53 MUC1
4 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 8.92 TP53 MUC1

Sources for Gallbladder Carcinoma in Situ

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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