Gallbladder Carcinoma in Situ disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Gallbladder Carcinoma in Situ

MalaCards integrated aliases for Gallbladder Carcinoma in Situ:

Name: Gallbladder Carcinoma in Situ ¹¹ ¹⁴

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Gastrointestinal diseases Immune diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050612

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Summaries for Gallbladder Carcinoma in Situ

Disease Ontology: ¹¹ An in situ carcinoma located in the surface epithelium of the gallbladder that most commonly develops into adenocarcinoma.

MalaCards based summary: Gallbladder Carcinoma in Situ is related to gallbladder cancer and colloid carcinoma of the pancreas. An important gene associated with Gallbladder Carcinoma in Situ is MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Metabolism of proteins and Diseases of glycosylation. Affiliated tissues include surface epithelium of the gallbladder, and related phenotypes are neoplasm and digestive/alimentary

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Related Diseases for Gallbladder Carcinoma in Situ

Diseases in the Gallbladder Cancer family:

Gallbladder Carcinoma in Situ

Diseases related to Gallbladder Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)

#	Related Disease	Score	Top Affiliating Genes
1	gallbladder cancer	28.5	TP53 MUC6 MUC5AC MUC1 CEACAM5 CDX2
2	colloid carcinoma of the pancreas	10.2	MUC5AC CDX2
3	anal gland adenocarcinoma	10.2	MUC5AC CDX2
4	anus adenocarcinoma	10.2	MUC5AC CDX2
5	anal canal adenocarcinoma	10.2	MUC5AC CDX2
6	mucoepidermoid carcinoma	10.2	MUC5AC MUC1
7	intrahepatic biliary papillomatosis	10.2	MUC5AC MUC1
8	bile reflux	10.1	MUC5AC CDX2
9	gallbladder signet ring cell adenocarcinoma	10.1	MUC1 CDX2
10	lynch syndrome 8	10.1	MUC5AC MUC1
11	medullary colon carcinoma	10.1	MUC1 CDX2
12	atypical polypoid adenomyoma	10.1	MME CDX2
13	breast hemangioma	10.1	TP53 CDX2
14	large cell carcinoma with rhabdoid phenotype	10.1	TP53 MUC5AC
15	adenomyoma	10.1	MUC1 MME
16	epididymis adenocarcinoma	10.1	MME CDX2
17	epididymis cancer	10.1	MME CDX2
18	clear cell adenocarcinoma	10.1	TP53 MME
19	uterus perivascular epithelioid cell tumor	10.1	MUC1 MME
20	chronic cystitis	10.1	TP53 CDX2
21	dry eye syndrome	10.1	MUC5AC MUC1
22	gastric tubular adenocarcinoma	10.1	MUC6 MUC5AC
23	gastric teratoma	10.1	MUC6 MUC5AC
24	vaginal carcinosarcoma	10.1	TP53 MME
25	sclerosing hemangioma	10.0	TP53 MUC1
26	breast metaplastic carcinoma	10.0	TP53 MME
27	pulmonary sclerosing hemangioma	10.0	TP53 MUC1
28	cystadenofibroma	10.0	TP53 MME
29	colon adenoma	10.0	TP53 CDX2
30	cervical adenosarcoma	10.0	TP53 MME
31	adenosarcoma	10.0	TP53 MME
32	breast malignant phyllodes tumor	10.0	TP53 MME
33	esophagus adenocarcinoma	10.0	TP53 CDX2
34	papilloma of choroid plexus	10.0	TP53 MUC1
35	intraductal breast benign neoplasm	10.0	TP53 MME
36	breast lobular carcinoma	10.0	TP53 MUC1
37	vaginal cancer	10.0	TP53 MME
38	pulmonary blastoma	10.0	TP53 MUC1
39	chronic lymphocytic leukemia/small lymphocytic lymphoma	10.0	TP53 MME
40	spindle cell sarcoma	10.0	TP53 MUC1
41	cervical polyp	10.0	MUC6 MME
42	rhabdoid cancer	10.0	TP53 MUC1
43	mesenchymal cell neoplasm	10.0	TP53 MME
44	connective tissue benign neoplasm	10.0	TP53 MME
45	laryngeal mucoepidermoid carcinoma	10.0	CEACAM5 CDX2
46	ureter adenocarcinoma	10.0	CEACAM5 CDX2
47	thymus adenocarcinoma	10.0	CEACAM5 CDX2
48	vaginal tubulovillous adenoma	10.0	CEACAM5 CDX2
49	vulva adenocarcinoma	10.0	CEACAM5 CDX2
50	ovarian cyst	10.0	MUC1 CEACAM5

Graphical network of the top 20 diseases related to Gallbladder Carcinoma in Situ:

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Symptoms & Phenotypes for Gallbladder Carcinoma in Situ

MGI Mouse Phenotypes related to Gallbladder Carcinoma in Situ:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.26	CDX2 CEACAM5 MUC1 TP53
2	digestive/alimentary	MP:0005381	9.02	CDX2 CEACAM5 MUC1 MUC5AC TP53

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Drugs & Therapeutics for Gallbladder Carcinoma in Situ

Search Clinical Trials, NIH Clinical Center for Gallbladder Carcinoma in Situ

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Genetic Tests for Gallbladder Carcinoma in Situ

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Anatomical Context for Gallbladder Carcinoma in Situ

Organs/tissues related to Gallbladder Carcinoma in Situ:

FMA: Surface Epithelium Of The Gallbladder

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Publications for Gallbladder Carcinoma in Situ

Articles related to Gallbladder Carcinoma in Situ:

#	Title	Authors	PMID	Year
1	Routine histopathology of gallbladder after elective cholecystectomy for gallstones: waste of resources or a justified act? ⁶²	Siddiqui FG...Ahmad L	23834815	2013
2	Implant metastasis of gallbladder carcinoma in situ in a cholecystectomy scar: a case report. ⁶²	Merz BJ...Kisken WA	8356516	1993

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Genes for Gallbladder Carcinoma in Situ

Genes related to Gallbladder Carcinoma in Situ (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	4.96	DISEASES inferred ¹⁴
2	CDX2	Caudal Type Homeobox 2	Protein Coding	4.83	DISEASES inferred ¹⁴
3	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	4.41	DISEASES inferred ¹⁴
4	MME	Membrane Metalloendopeptidase	Protein Coding	4.32	DISEASES inferred ¹⁴
5	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	4.11	DISEASES inferred ¹⁴
6	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.08	DISEASES inferred ¹⁴
7	TP53	Tumor Protein P53	Protein Coding	3.13	DISEASES inferred ¹⁴

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Variations for Gallbladder Carcinoma in Situ

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Expression for Gallbladder Carcinoma in Situ

Search GEO for disease gene expression data for Gallbladder Carcinoma in Situ.

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Pathways for Gallbladder Carcinoma in Situ

Pathways related to Gallbladder Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁶ Show member pathways Post-translational protein modification ⁶⁶	12.7	TP53 MUC6 MUC5AC MUC1 MME CEACAM5
2	Diseases of glycosylation ⁶⁶ Show member pathways Defective ALG1 causes CDG-1k ⁶⁶ Defective ALG11 causes CDG-1p ⁶⁶ Defective ALG12 causes CDG-1g ⁶⁶ Defective ALG14 causes ALG14-CMS ⁶⁶ Defective ALG2 causes CDG-1i ⁶⁶ Defective ALG3 causes CDG-1d ⁶⁶ Defective ALG6 causes CDG-1c ⁶⁶ Defective ALG8 causes CDG-1h ⁶⁶ Defective ALG9 causes CDG-1l ⁶⁶ Defective DPAGT1 causes CDG-1j, CMSTA2 ⁶⁶ Defective GNE causes sialuria, NK and IBM2 ⁶⁶ Defective MPDU1 causes CDG-1f ⁶⁶ Defective NEU1 causes sialidosis ⁶⁶ Defective RFT1 causes CDG-1n ⁶⁶ Diseases associated with glycosylation precursor biosynthesis ⁶⁶ Diseases associated with N-glycosylation of proteins ⁶⁶ Diseases of metabolism ⁶⁶ MPS IV - Morquio syndrome B ⁶⁶	12.23	MUC6 MUC5AC MUC1
3	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ⁶¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	11.9	MUC6 MUC5AC MUC1
4	O-linked glycosylation of mucins ⁶⁶ Show member pathways Defective C1GALT1C1 causes TNPS ⁶⁶ Defective GALNT12 causes CRCS1 ⁶⁶ Defective GALNT3 causes HFTC ⁶⁶ mucin core 1 and core 2 O-glycosylation ⁶¹ mucin core 3 and core 4 O-glycosylation ⁶¹ O-linked glycosylation ⁶⁶	11.8	MUC6 MUC5AC MUC1
5	Diseases associated with O-glycosylation of proteins ⁶⁶ Show member pathways Defective B3GALTL causes PpS ⁶⁶ Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 ⁶⁶ O-glycosylation of TSR domain-containing proteins ⁶⁶	11.49	MUC6 MUC5AC MUC1
6	Termination of O-glycan biosynthesis ⁶⁶ Show member pathways Dectin-2 family ⁶⁶ Maturation of protein 3a ⁶⁶ Maturation of protein 3a ⁶⁶	10.97	MUC6 MUC5AC MUC1
7	Cell adhesion_Cell-matrix glycoconjugates ²²	10.96	MUC1 CEACAM5

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GO Terms for Gallbladder Carcinoma in Situ

Cellular components related to Gallbladder Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	9.1	MUC6 MUC5AC MUC1

Biological processes related to Gallbladder Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.56	TP53 MUC1
2	replicative senescence	GO:0090399	9.46	TP53 MME
3	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.26	TP53 MUC1
4	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO:0036003	8.92	TP53 MUC1

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Sources for Gallbladder Carcinoma in Situ

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: GLL050 MIFTS: 22	Gallbladder Carcinoma in Situ Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases, Liver diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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