MCID: GLL020
MIFTS: 64

Gallbladder Disease

Categories: Gastrointestinal diseases, Nephrological diseases, Genetic diseases, Liver diseases, Rare diseases

Aliases & Classifications for Gallbladder Disease

MalaCards integrated aliases for Gallbladder Disease:

Name: Gallbladder Disease 12 37 15
Gallbladder Diseases 43 44
Abnormality of the Gallbladder 29
Abnormal Gallbladder Function 73
Gallbladder Dysfunction 29
Gall Bladder Diseases 73
Gall Bladder 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0060262
ICD10 33 K82.9 K82.8
ICD9CM 35 575.9
MeSH 44 D005705
NCIt 50 C34631
KEGG 37 H01213

Summaries for Gallbladder Disease

MedlinePlus : 43 Your gallbladder is a pear-shaped organ under your liver. It stores bile, a fluid made by your liver to digest fat. As your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. The duct connects your gallbladder and liver to your small intestine. Your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. That is usually a gallstone. Gallstones form when substances in bile harden. Rarely, you can also get cancer in your gallbladder. Many gallbladder problems get better with removal of the gallbladder. Fortunately, you can live without a gallbladder. Bile has other ways of reaching your small intestine.

MalaCards based summary : Gallbladder Disease, also known as gallbladder diseases, is related to gallbladder disease 4 and common bile duct disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Gallbladder Disease is GBD3 (Gallbladder Disease 3), and among its related pathways/superpathways are ABC transporters and Fat digestion and absorption. The drugs Ketamine and Nefopam have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lung, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system disease that is located in the gallbladder.

Wikipedia : 76 Gallbladder diseases are diseases involving the... more...

Related Diseases for Gallbladder Disease

Diseases in the Gallbladder Disease family:

Gallbladder Disease 1 Gallbladder Disease 2
Gallbladder Disease 3 Gallbladder Disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 gallbladder disease 4 34.7 ABCG5 ABCG8
2 common bile duct disease 31.8 CCK NODAL
3 arteries, anomalies of 29.3 APOA1 APOB APOE CETP INS
4 coronary artery anomaly 29.2 APOA1 APOB APOE CETP INS
5 dyspepsia 29.1 CCK CCKAR SST
6 myocardial infarction 28.6 APOA1 APOB APOE CETP IL10 INS
7 acute pancreatitis 28.3 CCK CCKAR IL10 SST
8 heart disease 28.2 APOA1 APOB APOE INS NODAL
9 diabetes mellitus, noninsulin-dependent 27.9 APOA1 APOB APOE CETP INS SST
10 cholelithiasis 27.0 ABCB4 ABCG5 ABCG8 APOE CCK CCKAR
11 gallbladder disease 1 12.2
12 gall bladder carcinoma in situ 12.1
13 gallbladder disease 2 12.0
14 gallbladder disease 3 12.0
15 fascioliasis 11.4
16 xanthoma disseminatum 10.8 APOB APOE
17 biliary dyskinesia 10.8
18 familial lcat deficiency 10.7 APOA1 APOE
19 hypercholesterolemia, autosomal dominant, type b 10.7 APOB APOE
20 defective apolipoprotein b-100 10.7 APOB APOE
21 sitosterolemia 10.7 ABCG5 ABCG8 APOB
22 hyperlipoproteinemia, type v 10.7 APOE INS
23 leukodystrophy, hypomyelinating, 3 10.6 APOA1 APOB APOE
24 hyperlipidemia, familial combined 10.6 APOA1 APOB APOE
25 hypobetalipoproteinemia, familial, 1 10.6 APOA1 APOB APOE
26 hyperlipoproteinemia, type iv 10.6 APOA1 APOB APOE
27 fetal macrosomia 10.6 APOA1 APOB INS
28 hypolipoproteinemia 10.6 APOA1 APOB APOE
29 acute transverse myelitis 10.5 APOA1 IL10
30 hypoalphalipoproteinemia, primary 10.5 APOA1 APOB CETP
31 carotid artery disease 10.5 APOA1 APOB APOE
32 hepatic lipase deficiency 10.5 APOA1 APOE
33 cerebral atherosclerosis 10.5 APOA1 APOE
34 homozygous familial hypercholesterolemia 10.5 ABCG5 ABCG8 APOB APOE
35 aortic atherosclerosis 10.4 ABCG5 ABCG8 APOE CETP
36 inherited metabolic disorder 10.4 APOA1 APOB INS UGT1A1
37 ischemic heart disease 10.4 APOA1 APOB APOE INS
38 miliaria rubra 10.3 CFTR IL10
39 hypertriglyceridemia, familial 10.3 APOA1 APOB CETP INS
40 hyperlipoproteinemia, type iii 10.3 APOA1 APOB APOE CETP
41 arcus corneae 10.3 APOA1 APOB APOE CETP
42 hyperalphalipoproteinemia 1 10.3 APOA1 APOB APOE CETP
43 cerebrovascular disease 10.3 APOA1 APOB APOE INS
44 abetalipoproteinemia 10.3 APOA1 APOB APOE CETP
45 coronary stenosis 10.3 APOA1 APOB APOE CETP
46 lecithin:cholesterol acyltransferase deficiency 10.3 APOA1 APOB APOE CETP
47 tangier disease 10.3 APOA1 APOB APOE CETP
48 irritable bowel syndrome 10.1 CCK IL10 MLN
49 duodenal disease 10.0 CCK NODAL
50 exocrine pancreatic insufficiency 10.0 CCK CCKAR CFTR

Comorbidity relations with Gallbladder Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Gallbladder Disease:



Diseases related to Gallbladder Disease

Symptoms & Phenotypes for Gallbladder Disease

UMLS symptoms related to Gallbladder Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Gallbladder Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.1 ABCG8 APOA1 APOB APOE CETP TTC39B

MGI Mouse Phenotypes related to Gallbladder Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
2 digestive/alimentary MP:0005381 10.1 CCKAR CFTR IL10 INS NODAL SST
3 growth/size/body region MP:0005378 10.1 INS NODAL SST TTC39B ABCB4 ABCG5
4 cardiovascular system MP:0005385 10.09 ABCB4 ABCG5 APOA1 APOB APOE CDO1
5 endocrine/exocrine gland MP:0005379 10.02 APOA1 APOE CCK CCKAR CDO1 CFTR
6 liver/biliary system MP:0005370 9.9 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
7 no phenotypic analysis MP:0003012 9.5 APOE CCK CFTR IL10 INS NODAL
8 reproductive system MP:0005389 9.28 NODAL ABCB4 ABCG5 APOB APOE CDO1

Drugs & Therapeutics for Gallbladder Disease

Drugs for Gallbladder Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 375)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Not Applicable 6740-88-1 3821
2 Nefopam Approved, Investigational Phase 4 13669-70-0
3
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
5
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
6
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
7
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
8
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
9
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
10
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
11
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
12
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
15
Isoflurane Approved, Vet_approved Phase 4,Not Applicable 26675-46-7 3763
16
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
17
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
18
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
19
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
20
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
21
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
22
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
23
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
24
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
25
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
26
Acetaminophen Approved Phase 4 103-90-2 1983
27
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
28
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
29
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
30
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
31
Morphine Approved, Investigational Phase 4 57-27-2 5288826
32
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
33
Ondansetron Approved Phase 4 99614-02-5 4595
34
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
35
Metronidazole Approved Phase 4,Phase 1 443-48-1 4173
36
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Not Applicable 128-13-2 31401
37
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
38
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
39
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
40
Tigecycline Approved Phase 4 220620-09-7 5282044
41
Lactulose Approved Phase 4 4618-18-2 11333
42
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
43
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
44
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
45
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
46
Tauroursodeoxycholic acid Approved, Investigational Phase 4 14605-22-2 12443252
47
Sulbactam Approved Phase 4 68373-14-8
48 Sultamicillin Approved, Investigational Phase 4 76497-13-7
49 tannic acid Approved, Nutraceutical Phase 4,Not Applicable
50
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 5785 54670067

Interventional clinical trials:

(show top 50) (show all 445)
# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
4 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
7 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
8 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
9 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
10 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
11 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
12 Effect IV Ibuprofen and Inflammatory Responses Completed NCT01938040 Phase 4 ibuprofen
13 A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
14 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
15 Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01540084 Phase 4 propofol
16 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
17 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
18 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
19 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
20 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
21 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
22 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
23 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
24 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
25 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
26 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
27 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
28 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
29 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
30 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
31 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
32 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
33 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
34 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
35 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
36 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
37 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
38 The Safety/Efficacy Of Rifaximin With/Without Lactulose In Subjects With A History Of Recurrent Hepatic Encephalopathy Completed NCT01842581 Phase 4 Rifaximin;Rifaximin and Lactulose
39 The Discovery of the Double Sphincter in Gallbladder Recruiting NCT01998451 Phase 4 Tauroursodeoxycholic acid
40 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Recruiting NCT03168555 Phase 4 chenodeoxycholic acid
41 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
42 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
43 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
44 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
45 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
46 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
47 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
48 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3
49 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
50 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3

Search NIH Clinical Center for Gallbladder Disease

Cochrane evidence based reviews: gallbladder diseases

Genetic Tests for Gallbladder Disease

Genetic tests related to Gallbladder Disease:

# Genetic test Affiliating Genes
1 Gallbladder Dysfunction 29
2 Abnormality of the Gallbladder 29

Anatomical Context for Gallbladder Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Disease:

19
The Gallbladder

MalaCards organs/tissues related to Gallbladder Disease:

41
Liver, Lung, Small Intestine, Testes, Breast, T Cells, Pancreas

Publications for Gallbladder Disease

Articles related to Gallbladder Disease:

(show top 50) (show all 472)
# Title Authors Year
1
Outcome of elective cholecystectomy for the treatment of gallbladder disease in dogs. ( 29595398 )
2018
2
Safety of single-incision robotic cholecystectomy for benign gallbladder disease: a systematic review. ( 29943057 )
2018
3
Is functional gallbladder disease truly increasing? Results from the Rochester Epidemiology Project. ( 29699698 )
2018
4
Routine Pathology and Postoperative Follow-Up are Not Cost-Effective in Cholecystectomy for Benign Gallbladder Disease. ( 29696323 )
2018
5
Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease. ( 29320323 )
2018
6
Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease: Results from a population-based gallstone surgery registry. ( 28400123 )
2017
7
Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladder disease. ( 29117670 )
2017
8
Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. ( 29161283 )
2017
9
Robot-assisted single-site compared with laparoscopic single-incision cholecystectomy for benign gallbladder disease: protocol for a randomized controlled trial. ( 28183345 )
2017
10
Sex and ethnic/racial-specific risk factors for gallbladder disease. ( 29221432 )
2017
11
When Does Assessment for Bile Duct Stones Need to Be Performed Prior to Cholecystectomy for Calculus Gallbladder Disease? ( 28669660 )
2017
12
Predictors of bile tree pathology in patients presenting with gallbladder disease. ( 28520575 )
2017
13
Surgical approach to gallbladder disease in rural Guatemala. ( 28985869 )
2017
14
Feline biliary tree and gallbladder disease: Aetiology, diagnosis and treatment ( 28438089 )
2017
15
Management of gallbladder disease after sleeve gastrectomy in a selected Lebanese population. ( 27178610 )
2016
16
Diabetes mellitus and the risk of gallbladder disease: A systematic review and meta-analysis of prospective studies. ( 26684168 )
2016
17
MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease. ( 27563024 )
2016
18
A case report of symptomatic gallbladder disease in the setting of peritoneal carcinomatosis originating from invasive lobular carcinoma of the breast. ( 27180323 )
2016
19
A Prospective Study of the Conservative Management of Asymptomatic Preoperative and Postoperative Gallbladder Disease in Bariatric Surgery. ( 27324135 )
2016
20
Functional gallbladder disease: Operative trends and short-term outcomes. ( 27129932 )
2016
21
The increasing incidence of gallbladder disease in children: A 20year perspective. ( 26951963 )
2016
22
Gallbladder disease in children. ( 27521713 )
2016
23
Contrast-enhanced ultrasound in gallbladder disease: a pictorial review. ( 27056746 )
2016
24
Surgical options for gallbladder disease. ( 27062758 )
2016
25
Vegetable protein intake is associated with lower gallbladder disease risk: Findings from the Women's Health Initiative prospective cohort. ( 27009631 )
2016
26
Tobacco smoking and the risk of gallbladder disease. ( 26898907 )
2016
27
Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies. ( 26901710 )
2016
28
A cross-sectional study of cardiorespiratory fitness and gallbladder disease. ( 27955793 )
2016
29
Implications of radiologic-pathologic correlation for gallbladder disease in children and young adults with sickle cell disease. ( 26109240 )
2015
30
Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation-erratum. ( 25969942 )
2015
31
Is transpapillary gallbladder stenting better than percutaneous cholecystostomy for the treatment of symptomatic gallbladder disease in decompensated cirrhotic patients? ( 25647724 )
2015
32
Transvaginal cholecystectomy vs conventional laparoscopic cholecystectomy for gallbladder disease: A meta-analysis. ( 25954114 )
2015
33
Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. ( 25763724 )
2015
34
Polypoid Lesions of the Gallbladder: Disease Spectrum with Pathologic Correlationa89Erratum. ( 26172366 )
2015
35
Interventional Approaches to Gallbladder Disease. ( 26200981 )
2015
36
Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array. ( 25920552 )
2015
37
Emergency Management of Gallbladder Disease: Are Acute Surgical Units the New Gold Standard? ( 26296834 )
2015
38
Body mass index, abdominal fatness and the risk of gallbladder disease. ( 26374741 )
2015
39
Dietary patterns and risk of gallbladder disease: a hospital-based case-control study in adult women. ( 25995720 )
2015
40
Novel Use of Long, Large-Caliber, Fenestrated Stents for Endoscopic Transpapillary Gallbladder Stenting for Therapy of Symptomatic Gallbladder Disease. ( 26233546 )
2015
41
Pain Provocation and Low Gallbladder Ejection Fraction with CCK Cholescintigraphy Are Not Predictive of Chronic Acalculous Gallbladder Disease Symptom Relief After Cholecystectomy. ( 24852884 )
2014
42
Gallbladder disease and cholecystectomies, active component, U.S. Armed Forces, 2004-2013. ( 24978472 )
2014
43
Prevalence, clinical investigation, and management of gallbladder disease in Rett syndrome. ( 24528171 )
2014
44
Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease. ( 22886779 )
2013
45
Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed. ( 23964136 )
2013
46
Gallbladder disease in an elderly patient. ( 23842824 )
2013
47
Surgical management of gallbladder disease in the very elderly: are we operating them at the right time? ( 23169310 )
2013
48
Gallbladder disease. ( 23826592 )
2013
49
Surgery for acute gallbladder disease in Sweden 1989-2006--a register study. ( 23356689 )
2013
50
Different expression of S100A8 in malignant and benign gallbladder diseases. ( 22806545 )
2013

Variations for Gallbladder Disease

Expression for Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for Gallbladder Disease

Pathways related to Gallbladder Disease according to KEGG:

37
# Name Kegg Source Accession
1 ABC transporters hsa02010
2 Fat digestion and absorption hsa04975
3 Bile secretion hsa04976

GO Terms for Gallbladder Disease

Cellular components related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.84 ABCB4 ABCG5 ABCG8 CFTR
2 endoplasmic reticulum lumen GO:0005788 9.81 APOA1 APOB APOE INS
3 early endosome GO:0005769 9.8 APOA1 APOB APOE CFTR
4 high-density lipoprotein particle GO:0034364 9.54 APOA1 APOE CETP
5 endosome lumen GO:0031904 9.52 APOB INS
6 very-low-density lipoprotein particle GO:0034361 9.5 APOA1 APOB APOE
7 ATP-binding cassette (ABC) transporter complex GO:0043190 9.48 ABCG5 ABCG8
8 endocytic vesicle lumen GO:0071682 9.43 APOA1 APOB APOE
9 discoidal high-density lipoprotein particle GO:0034365 9.4 APOA1 APOE
10 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOE
11 chylomicron GO:0042627 9.13 APOA1 APOB APOE
12 intermediate-density lipoprotein particle GO:0034363 8.8 APOA1 APOB APOE
13 extracellular region GO:0005576 10.16 APOA1 APOB APOE CCK CETP IL10
14 extracellular space GO:0005615 10.09 APOA1 APOB APOE CCK CETP IL10

Biological processes related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.99 APOA1 APOB APOE INS
2 response to lipopolysaccharide GO:0032496 9.96 ABCB4 APOB IL10 UGT1A1
3 negative regulation of inflammatory response GO:0050728 9.89 APOA1 APOE IL10
4 cholesterol metabolic process GO:0008203 9.87 APOA1 APOB APOE CETP
5 response to drug GO:0042493 9.87 ABCB4 ABCG5 ABCG8 APOA1 IL10 SST
6 response to glucocorticoid GO:0051384 9.85 CDO1 IL10 UGT1A1
7 steroid metabolic process GO:0008202 9.85 APOA1 APOB APOE CETP UGT1A1
8 retinoid metabolic process GO:0001523 9.84 APOA1 APOB APOE
9 response to organic substance GO:0010033 9.83 ABCB4 APOB IL10 INS UGT1A1
10 phospholipid transport GO:0015914 9.82 ABCG8 APOA1 CETP
11 cholesterol biosynthetic process GO:0006695 9.81 APOA1 APOE CFTR
12 lipid homeostasis GO:0055088 9.8 ABCB4 APOE CETP
13 cellular response to estradiol stimulus GO:0071392 9.79 ABCB4 IL10 UGT1A1
14 triglyceride homeostasis GO:0070328 9.79 APOA1 APOE CETP
15 triglyceride catabolic process GO:0019433 9.78 APOA1 APOB APOE
16 response to nutrient GO:0007584 9.77 ABCG5 ABCG8 APOA1 SST UGT1A1
17 lipoprotein metabolic process GO:0042157 9.75 APOA1 APOB APOE
18 reverse cholesterol transport GO:0043691 9.73 APOA1 APOE CETP
19 cholesterol homeostasis GO:0042632 9.73 ABCG5 ABCG8 APOA1 APOB APOE CETP
20 high-density lipoprotein particle remodeling GO:0034375 9.72 APOA1 APOE CETP
21 phosphatidylcholine metabolic process GO:0046470 9.71 APOA1 CETP
22 fatty acid homeostasis GO:0055089 9.71 APOE INS
23 positive regulation of lipid biosynthetic process GO:0046889 9.71 APOA1 APOE INS
24 response to glucagon GO:0033762 9.7 ABCB4 CDO1
25 high-density lipoprotein particle assembly GO:0034380 9.7 APOA1 APOE
26 phospholipid efflux GO:0033700 9.7 APOA1 APOE
27 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 APOA1 IL10
28 low-density lipoprotein particle remodeling GO:0034374 9.7 APOB APOE CETP
29 positive regulation of cholesterol esterification GO:0010873 9.69 APOA1 APOE
30 chylomicron assembly GO:0034378 9.69 APOA1 APOB APOE
31 high-density lipoprotein particle clearance GO:0034384 9.68 APOA1 APOE
32 phospholipid homeostasis GO:0055091 9.68 APOA1 CETP
33 intestinal cholesterol absorption GO:0030299 9.68 ABCG5 ABCG8
34 neuron projection regeneration GO:0031102 9.67 APOA1 APOE
35 chylomicron remnant clearance GO:0034382 9.67 APOB APOE
36 very-low-density lipoprotein particle remodeling GO:0034372 9.67 APOA1 APOE CETP
37 regulation of cholesterol transport GO:0032374 9.66 APOA1 APOE
38 regulation of Cdc42 protein signal transduction GO:0032489 9.65 APOA1 APOE
39 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 APOA1 IL10
40 very-low-density lipoprotein particle clearance GO:0034447 9.65 APOB APOE
41 chylomicron remodeling GO:0034371 9.65 APOA1 APOB APOE
42 positive regulation of dendritic spine maintenance GO:1902952 9.63 APOE INS
43 lipoprotein catabolic process GO:0042159 9.63 APOB APOE
44 negative regulation of intestinal phytosterol absorption GO:0010949 9.6 ABCG5 ABCG8
45 negative regulation of intestinal cholesterol absorption GO:0045796 9.59 ABCG5 ABCG8
46 lipoprotein biosynthetic process GO:0042158 9.58 APOA1 APOB APOE
47 cholesterol transport GO:0030301 9.55 ABCG8 APOA1 APOB CETP CFTR
48 cholesterol efflux GO:0033344 9.35 ABCG5 ABCG8 APOA1 APOB APOE
49 lipid transport GO:0006869 9.17 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
50 G-protein coupled receptor signaling pathway GO:0007186 10.23 APOA1 APOE CCK CCKAR INS MLN

Molecular functions related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.8 APOA1 APOB APOE CETP
2 ATPase activity GO:0016887 9.76 ABCB4 ABCG5 ABCG8 CFTR
3 phospholipid binding GO:0005543 9.65 APOA1 APOB APOE
4 hormone activity GO:0005179 9.62 CCK INS MLN SST
5 cholesterol binding GO:0015485 9.54 APOA1 APOE CETP
6 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.46 ABCB4 ABCG5 ABCG8 CFTR
7 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.43 APOA1 APOE
8 phospholipid transporter activity GO:0005548 9.43 ABCB4 APOA1 CETP
9 lipoprotein particle binding GO:0071813 9.4 APOA1 APOE
10 lipid transporter activity GO:0005319 9.26 APOA1 APOB APOE CETP
11 cholesterol transporter activity GO:0017127 9.1 ABCG5 ABCG8 APOA1 APOB APOE CETP

Sources for Gallbladder Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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