MCID: GLL020
MIFTS: 63

Gallbladder Disease

Categories: Gastrointestinal diseases, Genetic diseases, Liver diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Gallbladder Disease

MalaCards integrated aliases for Gallbladder Disease:

Name: Gallbladder Disease 12 37 15
Gallbladder Diseases 43 44
Abnormality of the Gallbladder 29
Abnormal Gallbladder Function 73
Gallbladder Dysfunction 29
Gall Bladder Diseases 73
Gall Bladder 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0060262
ICD10 33 K82.9 K82.8
ICD9CM 35 575.9
MeSH 44 D005705
NCIt 50 C34631
SNOMED-CT 68 39621005
KEGG 37 H01213

Summaries for Gallbladder Disease

MedlinePlus : 43 Your gallbladder is a pear-shaped organ under your liver. It stores bile, a fluid made by your liver to digest fat. As your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. The duct connects your gallbladder and liver to your small intestine. Your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. That is usually a gallstone. Gallstones form when substances in bile harden. Rarely, you can also get cancer in your gallbladder. Many gallbladder problems get better with removal of the gallbladder. Fortunately, you can live without a gallbladder. Bile has other ways of reaching your small intestine.

MalaCards based summary : Gallbladder Disease, also known as gallbladder diseases, is related to gallbladder disease 4 and common bile duct disease, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Gallbladder Disease is GBD2 (Gallbladder Disease 2), and among its related pathways/superpathways are ABC transporters and Fat digestion and absorption. The drugs Nefopam and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and testes, and related phenotypes are Decreased free cholesterol and cellular

Disease Ontology : 12 A gastrointestinal system disease that is located in the gallbladder.

Wikipedia : 76 Gallbladder diseases are diseases involving the... more...

Related Diseases for Gallbladder Disease

Diseases in the Gallbladder Disease family:

Gallbladder Disease 1 Gallbladder Disease 2
Gallbladder Disease 3 Gallbladder Disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 gallbladder disease 4 34.0 ABCG5 ABCG8
2 common bile duct disease 32.1 CCK NODAL
3 postcholecystectomy syndrome 32.0 CCK MLN
4 cholecystolithiasis 30.1 ABCB4 CCK
5 irritable bowel syndrome 30.0 CCK IL10 MLN
6 cholecystitis 29.8 ABCB4 CCK MUC2
7 coronary artery anomaly 29.7 APOA1 APOB CETP
8 arteries, anomalies of 29.6 APOA1 APOB APOE CETP INS
9 acute pancreatitis 29.6 CCK CCKAR CFTR IL10
10 diabetes mellitus, noninsulin-dependent 29.5 APOA1 APOB APOE CETP INS
11 myocardial infarction 29.5 APOA1 APOB APOE CETP IL10 INS
12 cholelithiasis 29.5 ABCB4 ABCG5 ABCG8 APOE CCK CCKAR
13 heart disease 29.4 APOA1 APOB APOE IL10 INS NODAL
14 gallbladder disease 1 12.4
15 gall bladder carcinoma in situ 12.3
16 gallbladder disease 2 12.1
17 gallbladder disease 3 12.1
18 fascioliasis 11.5
19 diphyllobothriasis 11.2
20 melancholia 11.2
21 distomatosis 11.2
22 biliary dyskinesia 10.9
23 bladder disease 10.9
24 bladder cancer 10.7
25 adenocarcinoma 10.3
26 myxozoa 10.3
27 xanthoma disseminatum 10.3 APOB APOE
28 cholestasis, progressive familial intrahepatic, 1 10.3 ABCB4 ABCG5 ABCG8
29 familial lcat deficiency 10.3 APOA1 APOE
30 hypercholesterolemia, autosomal dominant, type b 10.3 APOB APOE
31 sitosterolemia 10.3 ABCG5 ABCG8 APOB
32 defective apolipoprotein b-100 10.2 APOB APOE
33 leukodystrophy, hypomyelinating, 3 10.2 APOA1 APOB APOE
34 ischemic heart disease 10.2 APOA1 APOB APOE
35 acute transverse myelitis 10.2 APOA1 IL10
36 fetal macrosomia 10.2 APOA1 APOB INS
37 hypolipoproteinemia 10.2 APOA1 APOB APOE
38 huntington disease-like 1 10.2 APOB APOE CETP
39 hypoalphalipoproteinemia, primary 10.2 APOA1 APOB CETP
40 hypobetalipoproteinemia, familial, 2 10.2 APOA1 APOB CETP
41 carotid artery disease 10.2 APOA1 APOB APOE
42 homozygous familial hypercholesterolemia 10.2 ABCG5 ABCG8 APOB APOE
43 bladder adenocarcinoma 10.2
44 hepatic lipase deficiency 10.2 APOA1 APOE
45 miliaria rubra 10.2 CFTR IL10
46 aortic atherosclerosis 10.2 ABCG5 ABCG8 APOE CETP
47 acquired metabolic disease 10.2 APOA1 APOB INS
48 hyperlipoproteinemia, type v 10.2 APOA1 APOB APOE INS
49 inherited metabolic disorder 10.2 APOA1 APOB INS UGT1A1
50 hyperlipoproteinemia, type iii 10.2 APOA1 APOB APOE CETP

Comorbidity relations with Gallbladder Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Gallbladder Disease:



Diseases related to Gallbladder Disease

Symptoms & Phenotypes for Gallbladder Disease

UMLS symptoms related to Gallbladder Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Gallbladder Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.1 ABCG8 APOA1 APOB APOE CETP TTC39B

MGI Mouse Phenotypes related to Gallbladder Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
2 cardiovascular system MP:0005385 10.18 ABCB4 ABCG5 APOA1 APOB APOE IL10
3 digestive/alimentary MP:0005381 10.17 ABCB4 ABCG5 ABCG8 APOE CCKAR CFTR
4 growth/size/body region MP:0005378 10.15 ABCB4 ABCG5 APOB APOE CCKAR CFTR
5 homeostasis/metabolism MP:0005376 10.13 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
6 endocrine/exocrine gland MP:0005379 10.06 ABCB4 APOA1 APOE CCK CCKAR CFTR
7 hematopoietic system MP:0005397 10.02 ABCB4 ABCG5 APOE CFTR IL10 INS
8 immune system MP:0005387 9.85 ABCB4 ABCG5 APOB APOE CFTR IL10
9 liver/biliary system MP:0005370 9.7 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
10 muscle MP:0005369 9.17 ABCG5 APOB APOE IL10 INS NODAL

Drugs & Therapeutics for Gallbladder Disease

Drugs for Gallbladder Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 390)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Nefopam Approved, Investigational Phase 4 13669-70-0
2
Ketamine Approved, Vet_approved Phase 4,Not Applicable 6740-88-1 3821
3
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
5
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
6 tannic acid Approved Phase 4,Not Applicable
7
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
8
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
9
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
10
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
15
Isoflurane Approved, Vet_approved Phase 4,Not Applicable 26675-46-7 3763
16
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
17
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
18
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Not Applicable 128-13-2 31401
19
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
20
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
21
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
22
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
24
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
25
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
26
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
27
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
28
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
29
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
30
Morphine Approved, Investigational Phase 4 57-27-2 5288826
31
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
32
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
33
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
34
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
35
Ondansetron Approved Phase 4 99614-02-5 4595
36
Acetaminophen Approved Phase 4 103-90-2 1983
37
Metronidazole Approved Phase 4,Phase 1 443-48-1 4173
38
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
39
Tigecycline Approved Phase 4 220620-09-7 5282044
40
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
41
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
42
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
43
Lactulose Approved Phase 4 4618-18-2 11333
44
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
45
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
46
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
47
Sultamicillin Approved, Investigational Phase 4 76497-13-7
48
Sulbactam Approved Phase 4 68373-14-8
49
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 5785 54670067
50
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252

Interventional clinical trials:

(show top 50) (show all 475)
# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
4 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
7 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
8 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
9 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
10 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
11 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
12 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
13 Effect IV Ibuprofen and Inflammatory Responses Completed NCT01938040 Phase 4 ibuprofen
14 A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
15 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
16 Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01540084 Phase 4 propofol
17 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
18 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
19 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
20 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
21 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
22 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
23 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
24 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
25 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
26 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
27 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
28 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
29 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
30 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
31 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
32 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
33 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
34 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
35 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
36 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
37 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
38 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
39 The Safety/Efficacy Of Rifaximin With/Without Lactulose In Subjects With A History Of Recurrent Hepatic Encephalopathy Completed NCT01842581 Phase 4 Rifaximin;Rifaximin and Lactulose
40 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
41 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Active, not recruiting NCT03168555 Phase 4 chenodeoxycholic acid
42 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
43 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
44 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
45 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
46 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
47 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
48 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3
49 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Unknown status NCT02490111 Phase 3 DWJ1319;Placebo
50 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3

Search NIH Clinical Center for Gallbladder Disease

Cochrane evidence based reviews: gallbladder diseases

Genetic Tests for Gallbladder Disease

Genetic tests related to Gallbladder Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Gallbladder 29
2 Gallbladder Dysfunction 29

Anatomical Context for Gallbladder Disease

MalaCards organs/tissues related to Gallbladder Disease:

41
Liver, Small Intestine, Testes, Heart, Colon, Breast, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Disease:

19
The Gallbladder

Publications for Gallbladder Disease

Articles related to Gallbladder Disease:

(show top 50) (show all 521)
# Title Authors Year
1
Outcome of elective cholecystectomy for the treatment of gallbladder disease in dogs. ( 29595398 )
2018
2
Safety of single-incision robotic cholecystectomy for benign gallbladder disease: a systematic review. ( 29943057 )
2018
3
Is functional gallbladder disease truly increasing? Results from the Rochester Epidemiology Project. ( 29699698 )
2018
4
Routine Pathology and Postoperative Follow-Up are Not Cost-Effective in Cholecystectomy for Benign Gallbladder Disease. ( 29696323 )
2018
5
Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease. ( 29320323 )
2018
6
Scintigraphic Findings Beyond Ejection Fraction on Hepatobiliary Scintigraphy: Are They Correlated With Chronic Gallbladder Disease? ( 30153154 )
2018
7
Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study. ( 29178198 )
2018
8
Contrast-enhanced ultrasound complements two-dimensional ultrasonography in diagnosing gallbladder diseases in dogs. ( 29393556 )
2018
9
Robotic-assisted versus laparoscopic cholecystectomy for benign gallbladder diseases: a systematic review and meta-analysis. ( 29956028 )
2018
10
Relationship of Gallbladder Diseases with Sociodemographic Characteristics, Lifestyle, and Chronic Diseases in Northeastern China. ( 30469314 )
2018
11
Comet tail artifact on ultrasonography: is it a reliable finding of benign gallbladder diseases? ( 30481951 )
2018
12
Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease: Results from a population-based gallstone surgery registry. ( 28400123 )
2017
13
Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladder disease. ( 29117670 )
2017
14
Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. ( 29161283 )
2017
15
Robot-assisted single-site compared with laparoscopic single-incision cholecystectomy for benign gallbladder disease: protocol for a randomized controlled trial. ( 28183345 )
2017
16
Sex and ethnic/racial-specific risk factors for gallbladder disease. ( 29221432 )
2017
17
When Does Assessment for Bile Duct Stones Need to Be Performed Prior to Cholecystectomy for Calculus Gallbladder Disease? ( 28669660 )
2017
18
A cross-sectional study of cardiorespiratory fitness and gallbladder disease. ( 27955793 )
2017
19
Feline biliary tree and gallbladder disease: Aetiology, diagnosis and treatment ( 28438089 )
2017
20
Predictors of bile tree pathology in patients presenting with gallbladder disease. ( 28520575 )
2017
21
Surgical approach to gallbladder disease in rural Guatemala. ( 28985869 )
2017
22
The role of endoscopic ultrasound in the diagnosis of gallbladder diseases. ( 27619811 )
2017
23
Synchronous Breast Cancer and Gallbladder Diseases-A Chromosomal Analysis: A Pilot Study at a Tertiary Care Centre. ( 29217907 )
2017
24
Management of gallbladder disease after sleeve gastrectomy in a selected Lebanese population. ( 27178610 )
2016
25
Diabetes mellitus and the risk of gallbladder disease: A systematic review and meta-analysis of prospective studies. ( 26684168 )
2016
26
MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease. ( 27563024 )
2016
27
A case report of symptomatic gallbladder disease in the setting of peritoneal carcinomatosis originating from invasive lobular carcinoma of the breast. ( 27180323 )
2016
28
A Prospective Study of the Conservative Management of Asymptomatic Preoperative and Postoperative Gallbladder Disease in Bariatric Surgery. ( 27324135 )
2016
29
Functional gallbladder disease: Operative trends and short-term outcomes. ( 27129932 )
2016
30
The increasing incidence of gallbladder disease in children: A 20year perspective. ( 26951963 )
2016
31
Gallbladder disease in children. ( 27521713 )
2016
32
Contrast-enhanced ultrasound in gallbladder disease: a pictorial review. ( 27056746 )
2016
33
Surgical options for gallbladder disease. ( 27062758 )
2016
34
Vegetable protein intake is associated with lower gallbladder disease risk: Findings from the Women's Health Initiative prospective cohort. ( 27009631 )
2016
35
Tobacco smoking and the risk of gallbladder disease. ( 26898907 )
2016
36
Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies. ( 26901710 )
2016
37
Association of Bile Duct and Gallbladder Diseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus. ( 27478902 )
2016
38
Age, Predisposing Diseases, and Ultrasonographic Findings in Determining Clinical Outcome of Acute Acalculous Inflammatory Gallbladder Diseases in Children. ( 27550491 )
2016
39
Population-based cohort study of outcomes following cholecystectomy for benign gallbladder diseases. ( 27561954 )
2016
40
Population-based cohort study of variation in the use of emergency cholecystectomy for benign gallbladder diseases. ( 27748962 )
2016
41
Implications of radiologic-pathologic correlation for gallbladder disease in children and young adults with sickle cell disease. ( 26109240 )
2015
42
Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation-erratum. ( 25969942 )
2015
43
Is transpapillary gallbladder stenting better than percutaneous cholecystostomy for the treatment of symptomatic gallbladder disease in decompensated cirrhotic patients? ( 25647724 )
2015
44
Transvaginal cholecystectomy vs conventional laparoscopic cholecystectomy for gallbladder disease: A meta-analysis. ( 25954114 )
2015
45
Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. ( 25763724 )
2015
46
Polypoid Lesions of the Gallbladder: Disease Spectrum with Pathologic Correlationa89Erratum. ( 26172366 )
2015
47
Interventional Approaches to Gallbladder Disease. ( 26200981 )
2015
48
Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array. ( 25920552 )
2015
49
Emergency Management of Gallbladder Disease: Are Acute Surgical Units the New Gold Standard? ( 26296834 )
2015
50
Body mass index, abdominal fatness and the risk of gallbladder disease. ( 26374741 )
2015

Variations for Gallbladder Disease

Expression for Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for Gallbladder Disease

Pathways related to Gallbladder Disease according to KEGG:

37
# Name Kegg Source Accession
1 ABC transporters hsa02010
2 Fat digestion and absorption hsa04975
3 Bile secretion hsa04976

Pathways related to Gallbladder Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 ABCG5 ABCG8 APOA1 APOB APOE CETP
2
Show member pathways
11.96 APOA1 APOB APOE INS
3
Show member pathways
11.56 APOA1 APOB APOE
4 11.41 ABCB4 ABCG5 ABCG8 CFTR
5
Show member pathways
11.17 ABCG5 ABCG8 APOA1 APOB APOE CETP
6
Show member pathways
10.9 ABCG5 ABCG8 APOA1 APOB
7 10.68 APOA1 CFTR

GO Terms for Gallbladder Disease

Cellular components related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.84 APOA1 APOB APOE INS
2 apical plasma membrane GO:0016324 9.83 ABCB4 ABCG5 ABCG8 CFTR PDPN
3 early endosome GO:0005769 9.81 APOA1 APOB APOE CFTR
4 endosome lumen GO:0031904 9.55 APOB INS
5 high-density lipoprotein particle GO:0034364 9.54 APOA1 APOE CETP
6 very-low-density lipoprotein particle GO:0034361 9.5 APOA1 APOB APOE
7 ATP-binding cassette (ABC) transporter complex GO:0043190 9.46 ABCG5 ABCG8
8 endocytic vesicle lumen GO:0071682 9.43 APOA1 APOB APOE
9 discoidal high-density lipoprotein particle GO:0034365 9.4 APOA1 APOE
10 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOE
11 chylomicron GO:0042627 9.13 APOA1 APOB APOE
12 intermediate-density lipoprotein particle GO:0034363 8.8 APOA1 APOB APOE
13 extracellular region GO:0005576 10.13 APOA1 APOB APOE CCK CETP IL10
14 extracellular space GO:0005615 10.1 APOA1 APOB APOE CCK CETP IL10
15 integral component of plasma membrane GO:0005887 10.07 ABCB4 ABCG5 ABCG8 CCKAR CFTR PDPN

Biological processes related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.97 APOA1 APOB APOE INS
2 response to drug GO:0042493 9.95 ABCB4 ABCG5 ABCG8 APOA1 IL10 UGT1A1
3 negative regulation of inflammatory response GO:0050728 9.88 APOA1 APOE IL10
4 response to organic substance GO:0010033 9.87 APOB IL10 UGT1A1
5 cholesterol metabolic process GO:0008203 9.86 APOA1 APOB APOE CETP
6 response to nutrient GO:0007584 9.85 ABCG5 ABCG8 APOA1 UGT1A1
7 retinoid metabolic process GO:0001523 9.83 APOA1 APOB APOE
8 phospholipid transport GO:0015914 9.81 ABCG8 APOA1 CETP
9 cholesterol biosynthetic process GO:0006695 9.8 APOA1 APOE CFTR
10 lipid homeostasis GO:0055088 9.8 ABCB4 APOE CETP
11 triglyceride homeostasis GO:0070328 9.78 APOA1 APOE CETP
12 triglyceride catabolic process GO:0019433 9.77 APOA1 APOB APOE
13 steroid metabolic process GO:0008202 9.77 APOA1 APOB APOE CETP UGT1A1
14 drug transmembrane transport GO:0006855 9.75 ABCB4 ABCG5 ABCG8
15 lipoprotein metabolic process GO:0042157 9.74 APOA1 APOB APOE
16 reverse cholesterol transport GO:0043691 9.71 APOA1 APOE CETP
17 fatty acid homeostasis GO:0055089 9.7 APOE INS
18 regulation of cholesterol metabolic process GO:0090181 9.7 APOE TTC39B
19 high-density lipoprotein particle remodeling GO:0034375 9.7 APOA1 APOE CETP
20 high-density lipoprotein particle assembly GO:0034380 9.69 APOA1 APOE
21 phospholipid efflux GO:0033700 9.69 APOA1 APOE
22 positive regulation of lipid biosynthetic process GO:0046889 9.69 APOA1 APOE INS
23 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.68 APOA1 IL10
24 high-density lipoprotein particle clearance GO:0034384 9.68 APOA1 APOE
25 intestinal cholesterol absorption GO:0030299 9.68 ABCG5 ABCG8
26 phospholipid homeostasis GO:0055091 9.68 APOA1 CETP
27 positive regulation of cholesterol esterification GO:0010873 9.67 APOA1 APOE
28 low-density lipoprotein particle remodeling GO:0034374 9.67 APOB APOE CETP
29 chylomicron remnant clearance GO:0034382 9.66 APOB APOE
30 regulation of Cdc42 protein signal transduction GO:0032489 9.66 APOA1 APOE
31 regulation of cholesterol transport GO:0032374 9.65 APOA1 APOE
32 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 APOA1 IL10
33 very-low-density lipoprotein particle clearance GO:0034447 9.64 APOB APOE
34 positive regulation of dendritic spine maintenance GO:1902952 9.63 APOE INS
35 chylomicron assembly GO:0034378 9.63 APOA1 APOB APOE
36 lipoprotein catabolic process GO:0042159 9.62 APOB APOE
37 regulation of cholesterol efflux GO:0010874 9.61 CETP TTC39B
38 very-low-density lipoprotein particle remodeling GO:0034372 9.61 APOA1 APOE CETP
39 negative regulation of intestinal cholesterol absorption GO:0045796 9.59 ABCG5 ABCG8
40 negative regulation of intestinal phytosterol absorption GO:0010949 9.58 ABCG5 ABCG8
41 chylomicron remodeling GO:0034371 9.58 APOA1 APOB APOE
42 cholesterol transport GO:0030301 9.56 APOA1 APOB CETP CFTR
43 cholesterol efflux GO:0033344 9.55 ABCG5 ABCG8 APOA1 APOB APOE
44 lipoprotein biosynthetic process GO:0042158 9.5 APOA1 APOB APOE
45 lipid transport GO:0006869 9.5 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
46 cholesterol homeostasis GO:0042632 9.17 ABCG5 ABCG8 APOA1 APOB APOE CETP
47 lipid metabolic process GO:0006629 10.09 ABCB4 APOA1 APOB APOE CETP
48 regulation of signaling receptor activity GO:0010469 10.06 CCK IL10 INS MLN NODAL

Molecular functions related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.8 APOA1 APOB APOE CETP
2 ATPase activity GO:0016887 9.76 ABCB4 ABCG5 ABCG8 CFTR
3 phospholipid binding GO:0005543 9.69 APOA1 APOB APOE
4 hormone activity GO:0005179 9.65 CCK INS MLN
5 cholesterol binding GO:0015485 9.5 APOA1 APOE CETP
6 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.46 ABCB4 ABCG5 ABCG8 CFTR
7 drug transmembrane transporter activity GO:0015238 9.43 ABCG5 ABCG8
8 phospholipid transporter activity GO:0005548 9.43 ABCB4 APOA1 CETP
9 lipoprotein particle binding GO:0071813 9.4 APOA1 APOE
10 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.37 APOA1 APOE
11 lipid transporter activity GO:0005319 9.26 APOA1 APOB APOE CETP
12 cholesterol transporter activity GO:0017127 9.1 ABCG5 ABCG8 APOA1 APOB APOE CETP

Sources for Gallbladder Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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