Gallbladder Disease

Categories: Gastrointestinal diseases, Genetic diseases, Liver diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Gallbladder Disease

MalaCards integrated aliases for Gallbladder Disease:

Name: Gallbladder Disease 12 36 15 17
Gallbladder Diseases 42 44
Abnormal Gallbladder Function 70
Gall Bladder Diseases 70
Gall Bladder 54


External Ids:

Disease Ontology 12 DOID:0060262
KEGG 36 H01213
ICD9CM 34 575.9
MeSH 44 D005705
NCIt 50 C34631
SNOMED-CT 67 155807008
ICD10 32 K82.8 K82.9
UMLS 70 C0016977 C0232769

Summaries for Gallbladder Disease

MedlinePlus : 42 Your gallbladder is a pear-shaped organ under your liver. It stores bile, a fluid made by your liver to digest fat. As your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. The duct connects your gallbladder and liver to your small intestine. Your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. That is usually a gallstone. Gallstones form when substances in bile harden. Rarely, you can also get cancer in your gallbladder. Many gallbladder problems get better with removal of the gallbladder. Fortunately, you can live without a gallbladder. Bile has other ways of reaching your small intestine.

MalaCards based summary : Gallbladder Disease, also known as gallbladder diseases, is related to gallbladder disease 4 and cholecystitis, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Gallbladder Disease is GBD2 (Gallbladder Disease 2), and among its related pathways/superpathways are ABC transporters and Fat digestion and absorption. The drugs Lidocaine and Rocuronium have been mentioned in the context of this disorder. Affiliated tissues include gallbladder, liver and pancreas, and related phenotypes are Decreased free cholesterol and endocrine/exocrine gland

Disease Ontology : 12 A gastrointestinal system disease that is located in the gallbladder.

KEGG : 36 Gallbladder disease is one of the most common digestive disorders. Cholecystitis is an inflammation of the gallbladder wall, that is almost always associated with cholelithiasis, or gallstones. Cholecystitis and cholelithiasis appear to be caused by the actions of several genes and environment working together. It has been reported that an ABCB4 mutation which causes a deficiency in biliary phosphatidylcholine secretion is associated with gallstones. Recently, several common DNA polymorphisms in the ABCG8 gene were discovered that are associated with gallstone disease.

Wikipedia : 73 Gallbladder diseases are diseases involving the gallbladder and is closely linked to biliary disease,... more...

Related Diseases for Gallbladder Disease

Diseases in the Gallbladder Disease family:

Gallbladder Disease 1 Gallbladder Disease 2
Gallbladder Disease 3 Gallbladder Disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 479)
# Related Disease Score Top Affiliating Genes
1 gallbladder disease 4 33.0 ABCG8 ABCG5
2 cholecystitis 31.8 CCKAR CCK ABCB4
3 cholelithiasis 31.5 UGT1A1 INS CCKAR CCK APOE ABCG8
4 acalculous cholecystitis 31.3 CCKAR CCK
5 choledocholithiasis 31.0 UGT1A1 CCK ABCB4
6 biliary tract disease 31.0 MIR145 CCK ABCG5 ABCB4
7 leptin deficiency or dysfunction 30.8 INS IL10 CCKAR CCK
8 ileus 30.8 MLN INS IL10 CCK
9 postcholecystectomy syndrome 30.7 MLN CCK
10 acute pancreatitis 30.7 INS IL10 CCKAR CCK
11 irritable bowel syndrome 30.7 MLN IL10 CCK
12 hypercholesterolemia, familial, 1 30.6 INS CETP APOE APOB APOA1 ABCG8
13 lipid metabolism disorder 30.6 INS CETP APOE APOB APOA1
14 duodenal ulcer 30.5 MLN INS IL10 CCK
15 coronary heart disease 1 30.5 INS CETP APOE APOB APOA1
16 hypertriglyceridemia, familial 30.5 INS CETP APOE APOB APOA1
17 familial hypercholesterolemia 30.4 INS IL10 CETP APOE APOB APOA1
18 sitosterolemia 30.3 APOB APOA1 ABCG8 ABCG5 ABCB4
19 hyperlipoproteinemia, type iv 30.3 CETP APOE APOB APOA1 ABCG5
20 type 1 diabetes mellitus 30.2 INS IL10 CETP APOB APOA1
21 non-alcoholic fatty liver disease 30.2 INS IL10 APOE APOB APOA1
22 autonomic neuropathy 30.2 MLN INS CCK
23 arteries, anomalies of 30.2 MIR145 MIR143 INS APOE APOB APOA1
24 diabetes mellitus 30.2 MLN MIR145 INS IL10 CETP CCKAR
25 type 2 diabetes mellitus 30.1 INS IL10 CETP CCK APOE APOB
26 cholecystolithiasis 30.1 CCK ABCB4
27 bile duct disease 30.1 MIR145 CCK ABCB4
28 heart disease 30.1 MIR145 MIR143 INS IL10 CETP APOE
29 lipoprotein quantitative trait locus 30.1 MIR145 MIR143 INS IL10 CETP APOE
30 aortic aneurysm, familial abdominal, 1 30.0 IL10 CETP APOE
31 common bile duct disease 30.0 CCK ABCB4
32 gallbladder disease 1 11.6
33 gallbladder disease 2 11.3
34 gallbladder disease 3 11.3
35 fascioliasis 11.1
36 opisthorchiasis 11.1
37 diphyllobothriasis 11.1
38 distomatosis 11.1
39 bladder cancer 11.0
40 biliary dyskinesia 11.0
41 xanthoma disseminatum 10.5 APOE APOB
42 obstructive jaundice 10.5
43 adenocarcinoma 10.5
44 parenteral nutrition-associated cholestasis 10.5 CCK ABCB4
45 familial lcat deficiency 10.5 APOE APOA1
46 silent myocardial infarction 10.5 INS APOB APOA1
47 cholestasis, progressive familial intrahepatic, 3 10.5 ABCG8 ABCG5 ABCB4
48 cholestasis, progressive familial intrahepatic, 2 10.5 ABCG8 ABCG5 ABCB4
49 generalized atherosclerosis 10.5 INS APOE APOB
50 familial lipoprotein lipase deficiency 10.5 APOE APOB APOA1

Comorbidity relations with Gallbladder Disease via Phenotypic Disease Network (PDN):

Acute Cystitis Acute Pancreatitis
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Gallbladder Disease:

Diseases related to Gallbladder Disease

Symptoms & Phenotypes for Gallbladder Disease

UMLS symptoms related to Gallbladder Disease:

nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

GenomeRNAi Phenotypes related to Gallbladder Disease according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.32 ABCG8

MGI Mouse Phenotypes related to Gallbladder Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 ABCB4 APOA1 APOE CCK CCKAR CDO1
2 homeostasis/metabolism MP:0005376 9.77 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
3 liver/biliary system MP:0005370 9.32 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE

Drugs & Therapeutics for Gallbladder Disease

Drugs for Gallbladder Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Ibuprofen Approved Phase 4 15687-27-1 3672
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Meperidine Approved Phase 4 57-42-1 4058
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
9 Anesthetics, Local Phase 4
10 Anti-Arrhythmia Agents Phase 4
11 Sodium Channel Blockers Phase 4
12 Diuretics, Potassium Sparing Phase 4
13 Anesthetics Phase 4
14 Analgesics Phase 4
15 Neurotransmitter Agents Phase 4
16 Hypnotics and Sedatives Phase 4
17 Neuromuscular Nondepolarizing Agents Phase 4
18 Neuromuscular Blocking Agents Phase 4
19 Anticonvulsants Phase 4
20 Bromides Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Antirheumatic Agents Phase 4
23 Cyclooxygenase Inhibitors Phase 4
24 Anti-Inflammatory Agents Phase 4
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4
26 Psychotropic Drugs Phase 4
27 Anti-Anxiety Agents Phase 4
28 Calamus Phase 4
29 Narcotics Phase 4
30 Analgesics, Opioid Phase 4
31 Anesthetics, General Phase 4
32 GABA Modulators Phase 4
33 Anesthetics, Intravenous Phase 4
Ursodeoxycholic acid Approved, Investigational Phase 3 128-13-2 31401
Cisplatin Approved Phase 2, Phase 3 15663-27-1 84093 441203 2767
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
Gemcitabine Approved Phase 3 95058-81-4 60750
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
39 Immunosuppressive Agents Phase 2, Phase 3
40 Immunologic Factors Phase 2, Phase 3
41 Antimetabolites Phase 2, Phase 3
42 Antiviral Agents Phase 2, Phase 3
43 Anti-Infective Agents Phase 2, Phase 3
Neostigmine Approved, Vet_approved Phase 2 59-99-4 4456
Ondansetron Approved Phase 2 99614-02-5 4595
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
Bevacizumab Approved, Investigational Phase 2 216974-75-3
48 Cholinesterase Inhibitors Phase 2
49 Cholinergic Agents Phase 2
50 Antiemetics Phase 2

Interventional clinical trials:

(show top 50) (show all 87)
# Name Status NCT ID Phase Drugs
1 Comparison of Intravenous Lidocaine and Intraperitoneal Lidocaine Irrigation for Effective Pain Relief After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-blind, Placebo-controlled Study Unknown status NCT01608373 Phase 4 Intravenous lidocaine injection;Intraperitoneal lidocaine irrigation group;Intravenous normal saline injection
2 Randomized, Controlled, Parallel-Group, Double-Blind Trial to Compare the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures Using a 2x2 Factorial Design in Patients Undergoing Laparoscopic Cholecystectomy (Protocol No. MK-8616-076-03 Also Known as SCH 900616, P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
3 Randomized, Double Blind, Pilot Study on the Effect of Intravenous Ibuprofen on Inflammatory Responses in Patients Undergoing Surgery With General Anesthesia: Correlation With Clinical Outcomes Completed NCT01938040 Phase 4 ibuprofen
4 Cholecystocholangiography Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy: A Prospective Controlled Randomized Trial Completed NCT01103570 Phase 4
5 Multi-Port vs. Single-port Cholecystectomy Completed NCT01104727 Phase 4
6 Efficacy and Safety Profiles of Sedation With Propofol Combined With Intravenous Midazolam and Meperidine Versus Intravenous Midazolam and Meperidine for Ambulatory Endoscopic Retrograde-cholangiopancreatography(ERCP). Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
7 Cocktail Sedation Containing Propofol Versus Conventional Sedation for ERCP: a Prospective, Randomized Controlled Study Completed NCT01540084 Phase 4 propofol
8 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy: A Prospective Randomized Multicenter Placebo-Controlled Trial Unknown status NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
9 Double Blind Randomized Phase III Controlled Trial Comparing the Effect of Intraperitoneal Nebulization of Ropivacaine With Intraperitoneal Instillation of Ropivacaine on Pain Control After Laparoscopic Cholecystectomy Completed NCT01248819 Phase 3 Ropivacaine 60 mg;Ropivacaine 100 mg
10 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
11 Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers Recruiting NCT02867865 Phase 2, Phase 3 Gemcitabine;Cisplatin
12 Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Cholangiocarcinoma and Muscle Invasive Gall Bladder Carcinoma (ACTICCA-1 Trial) Recruiting NCT02170090 Phase 3 Gemcitabine;Cisplatin;Capecitabine
13 A Randomized, Multicenter, Open-label, Phase 3 Study to Compare the Efficacy and Safety of GEMOX(Gemcitabine/Oxaliplatin) vs XELOX(Xeloda/Oxaliplatin) in Advanced Biliary Tract Carcinoma Active, not recruiting NCT01470443 Phase 3 Oxaliplatin;Oxaliplatin
14 Phase II Study of Copanlisib (BAY 80-6946) in Combination With Gemcitabine and Cisplatin in Advanced Cholangiocarcinoma Completed NCT02631590 Phase 2 Cisplatin;Gemcitabine;Copanlisib
15 Prospective Evaluation of Laparoendoscopic Single Site Versus Laparoscopic Cholecystectomy Completed NCT00961506 Phase 2
16 Efficacy of Intraperitoneal Ondansetron Administration on Pain Relief After Laparoscopic Cholecystectomy Completed NCT04468685 Phase 2 Ondansetron;Normal saline
17 The Evaluation of the Analgesic Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Postoperative Pain in Laparoscopic Cholecystectomy:A Prospective, Randomized, Comparative, Double-blind Study. Completed NCT04244097 Phase 2 Bupivacaine Hydrochloride;Neostigmine
18 A Phase II Study of Triapine in Combination With Gemcitabine in Adenocarcinoma of the Biliary Ducts and Gall Bladder Completed NCT00075504 Phase 2 triapine;gemcitabine
19 A Multicenter Phase II Study of Gemcitabine, Capecitabine and Bevacizumab for Locally Advanced or Metastatic Adenocarcinoma of the Gall Bladder or Biliary Ducts. Completed NCT01007552 Phase 2 Gemcitabine, Capecitabine and Bevacizumab
20 Multi Institutional Phase II Trial of Single Agent Regorafenib in Refractory Advanced Biliary Cancers Active, not recruiting NCT02115542 Phase 2 Regorafenib
21 Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED) Terminated NCT00040131 Phase 2 IL-10
22 Phase 2, Multi-center, Open-label Trial to Evaluate Efficacy and Safety of GM-CT-01 in Combination With 5-FU as First Line Chemotherapy in Patients With Advanced Biliary Cancer Withdrawn NCT00386516 Phase 2 GM-CT-01;5-Fluorouracil
23 Altered Drug Disposition and Biomarkers for Diagnosis of Chronic Inflammatory Liver Disease. Completed NCT01766960 Phase 1 Morphine
24 Effect of Diphenhydramine Sedation During Endoscopic Retrograde Cholangio-pancreatography (ERCP) or Endoscopic Ultrasound (EUS) Withdrawn NCT00240123 Phase 1 Benadryl versus Placebo
25 Prospective Multicenter Human Randomized Controlled Evaluation of NOTES® Cholecystectomy Unknown status NCT01171027
26 Gall Bladder Status Among Children With Chronic Haemolytic Anemia Attending to Assuit University Children Hospital Unknown status NCT03533322
27 A Comparison of Robot-assisted Single Site and Laparoscopic Single-incision Cholecystectomy for Benign Gallbladder Unknown status NCT02485392
28 Evaluation Of Preoperative Scoring Method For Peridiction Of Difficult Laparoscopic Cholecystectomy Unknown status NCT03718572
29 Comparison of Postoperative Analgesia and Patient Satisfaction of Unilateral Transversus Abdominis Plane (TAP) Block and Trocar Site Infiltration Anesthesia in Laparoscopic Cholecystectomy Unknown status NCT03543202 Transversus abdominis plane block;local infiltration anesthesia;Intravenous patient controlled analgesia
30 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
31 Three-dimensional High-definition (3DHD) Laparoscopy Versus Two-dimensional High-definition (2DHD) Laparoscopy in Cholecystectomy: a Clinical Controlled Randomized Double Blinded Trial. Unknown status NCT02396927
32 A Trial to Evaluate Natural Orifice Transvaginal Endoscopic Cholecystectomy With Laparoscopic Assistance Completed NCT00889928
33 Endoscopic Retrograde CholangioPancreatography Endomicroscopy Registry Outcomes Database Completed NCT00779688
34 Does Three-Dimensional Laparoscopy Provide Significant Advantages for Patients and Surgeons? A Randomised Controlled Trial Investigating Operating Time and Surgical Errors With 3D vs 2D Visual Systems in Laparoscopic Cholecystectomies. Completed NCT01930344
35 A Novel Technique For Gall Bladder Fundus Retraction In Single Incision Laparoscopic Cholecystectomy Completed NCT01413633
36 Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine Completed NCT04407078 Sugammadex Injectable Product;Neostigmine Injectable Product
37 Cholecystoduodenal Fistula With and Without Gallstone Ileus: A Case Series Completed NCT03888976
38 "Emergency Bedside Ultrasonography of the Gallbladder: Does Fasting Matter?" Completed NCT00388830
39 Ajou University School of Medicine Completed NCT02827136 Lidocaine patch and hypafix;hypafix
40 Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine Completed NCT03583021 Sugammadex Injectable Product;Neostigmine Injectable Product
41 NOTES Transvaginal Cholecystectomy and Appendectomy Completed NCT00552162
42 The Comparison of Single Incision Laparoscopic Cholecystectomy and Three Port Laparoscopic Cholecystectomy Completed NCT01772745
43 Prospective Evaluation of Idiopathic Pancreatitis: Role of Endoscopic Ultrasonography Completed NCT00609726
44 The Feasibility and Safety of a Three-Port Laparoscopic Cholecystectomy Using a 2-mm Mini-Instrument Completed NCT01571479
45 Levita Magnetic Grasper Device Safety and Performance Study Completed NCT02049983
46 Cosmesis, Patient Satisfaction and Quality of Life After da Vinci Single Site and Multiport Laparoscopic Cholecystectomy Completed NCT01932216
47 A Prospective Investigation of the Use of the Fluorescence Imaging on the da Vinci Surgical System for Intra-operative Near Infrared Imaging of the Biliary Tree Completed NCT01410734 Indocyanine green (ICG)
48 Prospective Randomized Controlled Trial of Traditional Laparoscopic Cholecystectomy Versus SILS™ Port Laparoscopic Cholecystectomy Completed NCT00832767
49 Clipless Laparoscopic Cholecystectomy Using Harmonic Scalpel in Cirrhotic Patients a Prospective Randomized Study Completed NCT01009450
50 Interval Training Versus Electro Acupuncture on Liver Functions in Patients With Non-alcoholic Fatty Liver Disease Completed NCT03936803

Search NIH Clinical Center for Gallbladder Disease

Cochrane evidence based reviews: gallbladder diseases

Genetic Tests for Gallbladder Disease

Anatomical Context for Gallbladder Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Disease:


MalaCards organs/tissues related to Gallbladder Disease:

Liver, Pancreas, Small Intestine, Breast, Heart, Spinal Cord, Colon

Publications for Gallbladder Disease

Articles related to Gallbladder Disease:

(show top 50) (show all 2189)
# Title Authors PMID Year
Comparison of laparoscopic cholecystectomy with and without abdominal drainage in patients with non-complicated benign gallbladder disease: A protocol for systematic review and meta analysis. 42 61
32443316 2020
Association of gallbladder hyperkinesia with acalculous chronic cholecystitis: A case-control study. 42
32653205 2020
Long-term patient-reported outcomes following laparoscopic cholecystectomy: A prospective multicenter observational study. 42
32871883 2020
Nuclear medicine hepatobiliary imaging. 61 54
19879969 2010
Value of measuring gallbladder motility in clinical practice. 54 61
12974510 2003
Involvement of cholecystokinin/gastrin-related peptides and their receptors in clinical gastrointestinal disorders. 61 54
12688377 2002
Diagnostic accuracy of 99Tcm-HIDA with cholecystokinin and gallbladder ejection fraction in acalculous gallbladder disease. 61 54
11403177 2001
Sludge and stone formation in the gallbladder in bedridden elderly patients with cerebrovascular disease: influence of feeding method. 54 61
11388396 2001
Laparoscopic cholecystectomy for acalculous gallbladder disease. 61 54
16389335 2000
Endosonography/bile drainage combination for difficult-to-diagnose gallbladder disease. 61 54
9916588 1998
Acalculous gallbladder disease: US evaluation after slow-infusion cholecystokinin stimulation in symptomatic and asymptomatic adults. 61 54
9205230 1997
Cholelithiasis associated with medroxyprogesterone acetate therapy in men. 54 61
1385654 1992
Cholecystokinin cholescintigraphy: detection of abnormal gallbladder motor function in patients with chronic acalculous gallbladder disease. 54 61
1880571 1991
Results of surgical therapy for biliary dyskinesia. 61 54
1863213 1991
Clinical Yi-guan decoction for liver cirrhosis: A protocol for systematic review and meta analysis. 61
33787570 2021
[The surgical management of benign diseases of the gallbladder should be treated with caution]. 61
33706441 2021
The Impact of FASTPASS: A Collaboration With Emergency Department to Improve Management of Patients With Gallbladder Disease and Acute Appendicitis. 61
33360754 2021
Gallbladder Cryoablation: A Novel Option for High-Risk Patients with Gallbladder Disease. 61
33181108 2021
Epidemiological survey to determine the prevalence of cholecystolithiasis in Uyghur, Kazakh, and Han Ethnic Groups in the Xinjiang Uyghur Autonomous Region of China: cross-sectional studies. 61
33736598 2021
Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study. 61
33648505 2021
Selective or Routine Histology of Cholecystectomy Specimens for Diagnosing Incidental Carcinoma of Gallbladder and Correlation with Careful Intraoperative Macroscopic Examination? A Systematic Review. 61
33773526 2021
Generative models for predicting chemical composition of gallstones. 61
33755962 2021
Comparison of outcomes of single incision robotic cholecystectomy and single incision laparoscopic cholecystectomy. 61
33649258 2021
Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer. 61
33574564 2021
Minimally Invasive Approach Using Digital Single-Operator Peroral Cholangioscopy-Guided Electrohydraulic Lithotripsy and Endoscopic Nasogallbladder Drainage for the Management of HighGrade Mirizzi Syndrome. 61
33596635 2021
Natural language processing and entrustable professional activity text feedback in surgery: A machine learning model of resident autonomy. 61
33256944 2021
The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence. 61
32877720 2021
The minimally important difference of the Gastrointestinal Quality of Life Index for symptomatic gallstone surgery. 61
33398564 2021
33475504 2021
Difficult laparoscopic cholecystectomy and preoperative predictive factors. 61
33510220 2021
Early Outcomes of Robotic Single Site Cholecystectomy Using the DaVinci Xi® System. 61
33628004 2021
Emergency General Surgery and the Gallbladder: The Affordable Care Act's Impact on Practice Patterns. 61
32892131 2021
Sex Disparities in the Presentation of Gallbladder Disease. 61
33502230 2021
Outcomes of robotic and laparoscopic cholecystectomy for benign gallbladder disease in Veteran patients. 61
33400103 2021
Optimal Management of the Hyperkinetic Gallbladder: A Comparison of Outcomes Between Operative and Nonoperative Approaches. 61
33284026 2020
SARS-CoV-2 in the bile of a patient with COVID-19-associated gallbladder disease. 61
33147641 2020
A meta-analysis of indocyanine green fluorescence image-guided laparoscopic cholecystectomy for benign gallbladder disease. 61
32771612 2020
Laparoscopic cholecystectomy with two incisions: an improved, feasible and safe technique with superior cosmetic outcomes. 61
33351703 2020
Outcome after single-site robotic cholecystectomy: An initial single center's experience. 61
33264814 2020
Conversion from laparoscopic to open cholecystectomy: Risk factor analysis based on clinical, laboratory, and ultrasound parameters. 61
33358491 2020
A unique presentation of perforated duodenal ulcer in a postpartum woman: a case report. 61
33365115 2020
Port-site metastasis of unsuspected gallbladder carcinoma with ossification after laparoscopic cholecystectomy: A case report. 61
33344567 2020
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model. 61
32719544 2020
Cholecystocutaneous fistula incidence, Etiology, Clinical Manifestations, Diagnosis and treatment. A literature review. 61
33082947 2020
Impacts on outcomes and management of preoperative magnetic resonance cholangiopancreatography in patients scheduled for laparoscopic cholecystectomy: for whom it should be considered? 61
33029481 2020
Comparative Safety Assessment study for Drospirenone Induced Gallbladder Diseases using the Adverse Drug Reaction Database of USA, Europe, and Canada. 61
33109050 2020
Surgical trends in the management of acute cholecystitis during pregnancy. 61
33025256 2020
Changes in plasma bile acids are associated with gallbladder stones and polyps. 61
33129276 2020
Helicobacter pylori is not a contributing factor in gallbladder polyps or gallstones: a case-control matching study of Chinese individuals. 61
33045881 2020
Prenatal diethylstilbestrol exposure and risk of diabetes, gallbladder disease, and pancreatic disorders and malignancies. 61
33112220 2020

Variations for Gallbladder Disease

Expression for Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for Gallbladder Disease

Pathways related to Gallbladder Disease according to KEGG:

# Name Kegg Source Accession
1 ABC transporters hsa02010
2 Fat digestion and absorption hsa04975
3 Bile secretion hsa04976

GO Terms for Gallbladder Disease

Cellular components related to Gallbladder Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.09 MIR143 MECP2 INS IL10 CETP CCK
2 endoplasmic reticulum lumen GO:0005788 9.78 INS APOE APOB APOA1
3 very-low-density lipoprotein particle GO:0034361 9.54 APOE APOB APOA1
4 endocytic vesicle lumen GO:0071682 9.5 APOE APOB APOA1
5 ATP-binding cassette (ABC) transporter complex GO:0043190 9.46 ABCG8 ABCG5
6 low-density lipoprotein particle GO:0034362 9.43 APOE APOB APOA1
7 discoidal high-density lipoprotein particle GO:0034365 9.4 APOE APOA1
8 chylomicron GO:0042627 9.33 APOE APOB APOA1
9 intermediate-density lipoprotein particle GO:0034363 9.13 APOE APOB APOA1
10 high-density lipoprotein particle GO:0034364 8.92 CETP APOE APOB APOA1

Biological processes related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10.1 TTC39B CETP APOE APOB APOA1 ABCB4
2 response to drug GO:0042493 10.01 UGT1A1 IL10 APOA1 ABCG8 ABCG5
3 cellular protein metabolic process GO:0044267 10 INS APOE APOB APOA1
4 negative regulation of inflammatory response GO:0050728 9.92 MIR145 IL10 APOE APOA1
5 cholesterol metabolic process GO:0008203 9.91 CETP APOE APOB APOA1
6 response to organic substance GO:0010033 9.89 UGT1A1 IL10 APOB
7 response to glucocorticoid GO:0051384 9.87 UGT1A1 IL10 CDO1
8 retinoid metabolic process GO:0001523 9.86 APOE APOB APOA1
9 response to nutrient GO:0007584 9.85 UGT1A1 APOA1 ABCG8 ABCG5
10 lipid homeostasis GO:0055088 9.84 CETP APOE ABCB4
11 phospholipid transport GO:0015914 9.82 CETP APOA1 ABCG8
12 steroid metabolic process GO:0008202 9.8 UGT1A1 CETP APOE APOB APOA1
13 lipoprotein metabolic process GO:0042157 9.75 APOE APOB APOA1
14 cholesterol transport GO:0030301 9.74 CETP APOB APOA1
15 phosphatidylcholine metabolic process GO:0046470 9.73 MECP2 CETP APOA1
16 fatty acid homeostasis GO:0055089 9.72 INS APOE
17 phospholipid homeostasis GO:0055091 9.72 CETP APOA1
18 regulation of cholesterol metabolic process GO:0090181 9.72 TTC39B APOE
19 triglyceride homeostasis GO:0070328 9.72 CETP APOE APOA1 ABCG8 ABCG5
20 bile acid signaling pathway GO:0038183 9.71 ABCG8 ABCG5
21 high-density lipoprotein particle assembly GO:0034380 9.71 APOE APOA1
22 phospholipid efflux GO:0033700 9.71 APOE APOA1
23 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.71 IL10 APOA1
24 positive regulation of lipid biosynthetic process GO:0046889 9.71 INS APOE APOA1
25 high-density lipoprotein particle clearance GO:0034384 9.7 APOE APOA1
26 intestinal cholesterol absorption GO:0030299 9.7 ABCG8 ABCG5
27 angiotensin-activated signaling pathway GO:0038166 9.7 MIR145 MIR143
28 reverse cholesterol transport GO:0043691 9.7 CETP APOE APOA1
29 lipid transport GO:0006869 9.7 CETP APOE APOB APOA1 ABCG8 ABCG5
30 positive regulation of cholesterol esterification GO:0010873 9.69 APOE APOA1
31 high-density lipoprotein particle remodeling GO:0034375 9.69 CETP APOE APOA1
32 negative regulation of fatty acid metabolic process GO:0045922 9.68 UGT1A1 INS
33 chylomicron remnant clearance GO:0034382 9.68 APOE APOB
34 regulation of Cdc42 protein signal transduction GO:0032489 9.68 APOE APOA1
35 very-low-density lipoprotein particle clearance GO:0034447 9.68 APOE APOB
36 regulation of cholesterol efflux GO:0010874 9.67 TTC39B CETP
37 negative regulation of cytokine production involved in immune response GO:0002719 9.67 IL10 APOA1
38 low-density lipoprotein particle remodeling GO:0034374 9.67 CETP APOE APOB
39 positive regulation of phospholipid transport GO:2001140 9.66 CETP ABCB4
40 aorta smooth muscle tissue morphogenesis GO:0060414 9.66 MIR145 MIR143
41 lipoprotein catabolic process GO:0042159 9.65 APOE APOB
42 positive regulation of cholesterol transport GO:0032376 9.65 CETP ABCB4
43 glucocorticoid metabolic process GO:0008211 9.65 MECP2 APOA1
44 chylomicron assembly GO:0034378 9.65 APOE APOB APOA1
45 cholesterol efflux GO:0033344 9.65 APOE APOB APOA1 ABCG8 ABCG5
46 positive regulation of phospholipid efflux GO:1902995 9.64 APOE APOA1
47 positive regulation of dendritic spine maintenance GO:1902952 9.63 INS APOE
48 regulation of phenotypic switching GO:1900239 9.63 MIR145 MIR143
49 very-low-density lipoprotein particle remodeling GO:0034372 9.63 CETP APOE APOA1
50 chylomicron remodeling GO:0034371 9.61 APOE APOB APOA1

Molecular functions related to Gallbladder Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid transporter activity GO:0005548 9.37 CETP ABCB4
2 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.33 ABCG8 ABCG5 ABCB4
3 lipoprotein particle binding GO:0071813 9.32 APOE APOA1
4 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.26 APOE APOA1
5 lipid transporter activity GO:0005319 9.13 APOE APOB APOA1
6 intermembrane cholesterol transfer activity GO:0120020 9.1 CETP APOE APOB APOA1 ABCG8 ABCG5

Sources for Gallbladder Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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