MCID: GLL020
MIFTS: 64

Gallbladder Disease

Categories: Gastrointestinal diseases, Genetic diseases, Liver diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Gallbladder Disease

MalaCards integrated aliases for Gallbladder Disease:

Name: Gallbladder Disease 12 38 15 17
Gallbladder Diseases 44 45
Abnormality of the Gallbladder 30
Abnormal Gallbladder Function 74
Gallbladder Dysfunction 30
Gall Bladder Diseases 74
Gall Bladder 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0060262
KEGG 38 H01213
ICD9CM 36 575.9
MeSH 45 D005705
NCIt 51 C34631
SNOMED-CT 69 39621005
ICD10 34 K82.8 K82.9

Summaries for Gallbladder Disease

MedlinePlus : 44 Your gallbladder is a pear-shaped organ under your liver. It stores bile, a fluid made by your liver to digest fat. As your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. The duct connects your gallbladder and liver to your small intestine. Your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. That is usually a gallstone. Gallstones form when substances in bile harden. Rarely, you can also get cancer in your gallbladder. Many gallbladder problems get better with removal of the gallbladder. Fortunately, you can live without a gallbladder. Bile has other ways of reaching your small intestine.

MalaCards based summary : Gallbladder Disease, also known as gallbladder diseases, is related to gallbladder disease 4 and postcholecystectomy syndrome, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Gallbladder Disease is GBD2 (Gallbladder Disease 2), and among its related pathways/superpathways are ABC transporters and Fat digestion and absorption. The drugs Remifentanil and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and small intestine, and related phenotypes are Decreased free cholesterol and cardiovascular system

Disease Ontology : 12 A gastrointestinal system disease that is located in the gallbladder.

Wikipedia : 77 Gallbladder diseases are diseases involving the... more...

Related Diseases for Gallbladder Disease

Diseases in the Gallbladder Disease family:

Gallbladder Disease 1 Gallbladder Disease 2
Gallbladder Disease 3 Gallbladder Disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 gallbladder disease 4 34.3 ABCG5 ABCG8
2 postcholecystectomy syndrome 32.2 CCK MLN
3 cholecystolithiasis 30.3 ABCB4 CCK
4 irritable bowel syndrome 30.1 CCK IL10 MLN
5 coronary artery anomaly 29.9 APOA1 APOB CETP
6 acute pancreatitis 29.8 CCK CCKAR IL10
7 diabetes mellitus, noninsulin-dependent 29.8 APOA1 APOB APOE CETP INS
8 arteries, anomalies of 29.7 APOA1 APOB APOE CETP INS
9 heart disease 29.7 APOA1 APOB APOE IL10 INS
10 myocardial infarction 29.5 APOA1 APOB APOE CETP IL10 INS
11 cholelithiasis 29.4 ABCB4 ABCG5 ABCG8 APOE CCK CCKAR
12 gallbladder disease 1 12.5
13 gall bladder carcinoma in situ 12.3
14 gallbladder disease 2 12.1
15 gallbladder disease 3 12.1
16 fascioliasis 11.5
17 common bile duct disease 11.4
18 diphyllobothriasis 11.2
19 melancholia 11.2
20 distomatosis 11.2
21 biliary dyskinesia 10.9
22 bladder disease 10.9
23 bladder cancer 10.7
24 midline interhemispheric variant of holoprosencephaly 10.6
25 pleural empyema 10.5
26 xanthoma disseminatum 10.4 APOB APOE
27 familial lcat deficiency 10.4 APOA1 APOE
28 adenocarcinoma 10.4
29 hypercholesterolemia, autosomal dominant, type b 10.4 APOB APOE
30 cholestasis, progressive familial intrahepatic, 1 10.4 ABCB4 ABCG5 ABCG8
31 sitosterolemia 10.4 ABCG5 ABCG8 APOB
32 acute transverse myelitis 10.4 APOA1 IL10
33 defective apolipoprotein b-100 10.4 APOB APOE
34 leukodystrophy, hypomyelinating, 3 10.4 APOA1 APOB APOE
35 ischemic heart disease 10.4 APOA1 APOB APOE
36 hypolipoproteinemia 10.4 APOA1 APOB APOE
37 fetal macrosomia 10.4 APOA1 APOB INS
38 huntington disease-like 1 10.3 APOB APOE CETP
39 hypoalphalipoproteinemia, primary 10.3 APOA1 APOB CETP
40 hypobetalipoproteinemia, familial, 2 10.3 APOA1 APOB CETP
41 myxozoa 10.3
42 hepatic lipase deficiency 10.3 APOA1 APOE
43 carotid artery disease 10.3 APOA1 APOB APOE
44 homozygous familial hypercholesterolemia 10.3 ABCG5 ABCG8 APOB APOE
45 acquired metabolic disease 10.3 APOA1 APOB INS
46 aortic atherosclerosis 10.3 ABCG5 ABCG8 APOE CETP
47 cerebral atherosclerosis 10.3 APOA1 APOE
48 hyperlipoproteinemia, type v 10.3 APOA1 APOB APOE INS
49 functional gastric disease 10.3 CCK INS MLN
50 inherited metabolic disorder 10.3 APOA1 APOB INS UGT1A1

Comorbidity relations with Gallbladder Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Gallbladder Disease:



Diseases related to Gallbladder Disease

Symptoms & Phenotypes for Gallbladder Disease

UMLS symptoms related to Gallbladder Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Gallbladder Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.1 ABCG8 APOA1 APOB APOE CETP TTC39B

MGI Mouse Phenotypes related to Gallbladder Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ABCB4 ABCG5 APOA1 APOB APOE IL10
2 digestive/alimentary MP:0005381 9.86 ABCB4 ABCG5 ABCG8 APOE CCKAR IL10
3 endocrine/exocrine gland MP:0005379 9.81 ABCB4 APOA1 APOE CCK CCKAR IL10
4 homeostasis/metabolism MP:0005376 9.8 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
5 liver/biliary system MP:0005370 9.36 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE

Drugs & Therapeutics for Gallbladder Disease

Drugs for Gallbladder Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 405)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
2
Ketamine Approved, Vet_approved Phase 4,Not Applicable 6740-88-1 3821
3
Nefopam Approved, Investigational Phase 4 13669-70-0
4
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
5
tannic acid Approved Phase 4,Not Applicable 1401-55-4
6
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
7
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
8
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
9
Esketamine Approved, Investigational Phase 4 33643-46-8
10
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
11
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
12
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
15
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
16
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
17
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Not Applicable 128-13-2 31401
18
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
19
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
20
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
21
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
22
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
23
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
24
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
25
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
26
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
27
Ondansetron Approved Phase 4 99614-02-5 4595
28
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
29
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
30
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
31
Ketorolac Approved Phase 4,Not Applicable 66635-83-4, 74103-06-3 3826
32
Acetaminophen Approved Phase 4 103-90-2 1983
33
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
34
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
35
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
36
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
37
Sulbactam Approved Phase 4 68373-14-8
38
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
39
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
40
Sultamicillin Approved, Investigational Phase 4 76497-13-7
41
Metronidazole Approved Phase 4,Phase 1 443-48-1 4173
42
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
43
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
44
Tigecycline Approved Phase 4 220620-09-7 5282044
45
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
46
Lactulose Approved Phase 4 4618-18-2 11333
47
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173 46783403
48
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 5785 54670067
49
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
50
Taurochenodeoxycholic acid Experimental Phase 4 516-35-8 387316

Interventional clinical trials:

(show top 50) (show all 481)
# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
4 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
5 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
6 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
7 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
8 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
9 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
10 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
11 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
12 Effect IV Ibuprofen and Inflammatory Responses Completed NCT01938040 Phase 4 ibuprofen
13 A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
14 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
15 Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01540084 Phase 4 propofol
16 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
17 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
18 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
19 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
20 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
21 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
22 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
23 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
24 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
25 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
26 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
27 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
28 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
29 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
30 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
31 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
32 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
33 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
34 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
35 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
36 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
37 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Active, not recruiting NCT03168555 Phase 4 chenodeoxycholic acid
38 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
39 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
40 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
41 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
42 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
43 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
44 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
45 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
46 The Safety/Efficacy Of Rifaximin With/Without Lactulose In Subjects With A History Of Recurrent Hepatic Encephalopathy Completed NCT01842581 Phase 4 Rifaximin;Rifaximin and Lactulose
47 Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma Unknown status NCT01755013 Phase 2, Phase 3
48 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Unknown status NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
49 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
50 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3

Search NIH Clinical Center for Gallbladder Disease

Cochrane evidence based reviews: gallbladder diseases

Genetic Tests for Gallbladder Disease

Genetic tests related to Gallbladder Disease:

# Genetic test Affiliating Genes
1 Gallbladder Dysfunction 30
2 Abnormality of the Gallbladder 30

Anatomical Context for Gallbladder Disease

MalaCards organs/tissues related to Gallbladder Disease:

42
Liver, Lung, Small Intestine, Breast, Pancreas, Testes, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Disease:

20
The Gallbladder

Publications for Gallbladder Disease

Articles related to Gallbladder Disease:

(show top 50) (show all 531)
# Title Authors Year
1
Letter to Editor: Routine Pathology and Postoperative Follow-Up are Not Cost-Effective in Cholecystectomy for Benign Gallbladder Disease. ( 30680500 )
2019
2
Evaluating the early impact of Medicaid expansion on trends in diagnosis and treatment of benign gallbladder disease in Kentucky. ( 30704668 )
2019
3
Authors' Reply: Routine Pathology and Postoperative Follow-Up are not Cost-Effective in Cholecystectomy for Benign Gallbladder Disease. ( 30761405 )
2019
4
Big data and analysis of risk factors for gallbladder disease in the young generation of Korea. ( 30794560 )
2019
5
Correction to: Authors' Reply: Routine Pathology and Postoperative Follow-Up are not Cost-Effective in Cholecystectomy for Benign Gallbladder Disease. ( 30805681 )
2019
6
Correction: Big data and analysis of risk factors for gallbladder disease in the young generation of Korea. ( 30865731 )
2019
7
Gallbladder Disease in Children: A 20-year Single-centre Experience. ( 30898989 )
2019
8
Outcome of elective cholecystectomy for the treatment of gallbladder disease in dogs. ( 29595398 )
2018
9
Safety of single-incision robotic cholecystectomy for benign gallbladder disease: a systematic review. ( 29943057 )
2018
10
Is functional gallbladder disease truly increasing? Results from the Rochester Epidemiology Project. ( 29699698 )
2018
11
Routine Pathology and Postoperative Follow-Up are Not Cost-Effective in Cholecystectomy for Benign Gallbladder Disease. ( 29696323 )
2018
12
Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease. ( 29320323 )
2018
13
Scintigraphic Findings Beyond Ejection Fraction on Hepatobiliary Scintigraphy: Are They Correlated With Chronic Gallbladder Disease? ( 30153154 )
2018
14
Increased incidence of cholecystectomy related to gallbladder disease in France: Analysis of 807,307 cholecystectomy procedures over a period of seven years. ( 30573436 )
2018
15
Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study. ( 29178198 )
2018
16
Contrast-enhanced ultrasound complements two-dimensional ultrasonography in diagnosing gallbladder diseases in dogs. ( 29393556 )
2018
17
Robotic-assisted versus laparoscopic cholecystectomy for benign gallbladder diseases: a systematic review and meta-analysis. ( 29956028 )
2018
18
Relationship of Gallbladder Diseases with Sociodemographic Characteristics, Lifestyle, and Chronic Diseases in Northeastern China. ( 30469314 )
2018
19
Comet tail artifact on ultrasonography: is it a reliable finding of benign gallbladder diseases? ( 30481951 )
2018
20
Contrast-enhanced ultrasound (CEUS) for the evaluation of gallbladder diseases in comparison to cross-sectional imaging modalities and histopathological results. ( 30584126 )
2018
21
Contrast-enhanced ultrasound (CEUS) and gallbladder diseases - a retrospective mono-center analysis of imaging findings with histopathological correlation. ( 30584127 )
2018
22
Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease: Results from a population-based gallstone surgery registry. ( 28400123 )
2017
23
Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladder disease. ( 29117670 )
2017
24
Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. ( 29161283 )
2017
25
Robot-assisted single-site compared with laparoscopic single-incision cholecystectomy for benign gallbladder disease: protocol for a randomized controlled trial. ( 28183345 )
2017
26
Sex and ethnic/racial-specific risk factors for gallbladder disease. ( 29221432 )
2017
27
When Does Assessment for Bile Duct Stones Need to Be Performed Prior to Cholecystectomy for Calculus Gallbladder Disease? ( 28669660 )
2017
28
Predictors of bile tree pathology in patients presenting with gallbladder disease. ( 28520575 )
2017
29
Surgical approach to gallbladder disease in rural Guatemala. ( 28985869 )
2017
30
Feline biliary tree and gallbladder disease: Aetiology, diagnosis and treatment ( 28438089 )
2017
31
The role of endoscopic ultrasound in the diagnosis of gallbladder diseases. ( 27619811 )
2017
32
Synchronous Breast Cancer and Gallbladder Diseases-A Chromosomal Analysis: A Pilot Study at a Tertiary Care Centre. ( 29217907 )
2017
33
Management of gallbladder disease after sleeve gastrectomy in a selected Lebanese population. ( 27178610 )
2016
34
Diabetes mellitus and the risk of gallbladder disease: A systematic review and meta-analysis of prospective studies. ( 26684168 )
2016
35
MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease. ( 27563024 )
2016
36
A case report of symptomatic gallbladder disease in the setting of peritoneal carcinomatosis originating from invasive lobular carcinoma of the breast. ( 27180323 )
2016
37
A Prospective Study of the Conservative Management of Asymptomatic Preoperative and Postoperative Gallbladder Disease in Bariatric Surgery. ( 27324135 )
2016
38
Functional gallbladder disease: Operative trends and short-term outcomes. ( 27129932 )
2016
39
The increasing incidence of gallbladder disease in children: A 20year perspective. ( 26951963 )
2016
40
Gallbladder disease in children. ( 27521713 )
2016
41
Contrast-enhanced ultrasound in gallbladder disease: a pictorial review. ( 27056746 )
2016
42
Surgical options for gallbladder disease. ( 27062758 )
2016
43
Vegetable protein intake is associated with lower gallbladder disease risk: Findings from the Women's Health Initiative prospective cohort. ( 27009631 )
2016
44
Tobacco smoking and the risk of gallbladder disease. ( 26898907 )
2016
45
Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies. ( 26901710 )
2016
46
A cross-sectional study of cardiorespiratory fitness and gallbladder disease. ( 27955793 )
2016
47
Association of Bile Duct and Gallbladder Diseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus. ( 27478902 )
2016
48
Age, Predisposing Diseases, and Ultrasonographic Findings in Determining Clinical Outcome of Acute Acalculous Inflammatory Gallbladder Diseases in Children. ( 27550491 )
2016
49
Population-based cohort study of outcomes following cholecystectomy for benign gallbladder diseases. ( 27561954 )
2016
50
Population-based cohort study of variation in the use of emergency cholecystectomy for benign gallbladder diseases. ( 27748962 )
2016

Variations for Gallbladder Disease

Expression for Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for Gallbladder Disease

Pathways related to Gallbladder Disease according to KEGG:

38
# Name Kegg Source Accession
1 ABC transporters hsa02010
2 Fat digestion and absorption hsa04975
3 Bile secretion hsa04976

GO Terms for Gallbladder Disease

Cellular components related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.83 ABCB4 ABCG5 ABCG8 PDPN
2 endoplasmic reticulum lumen GO:0005788 9.8 APOA1 APOB APOE INS
3 secretory granule lumen GO:0034774 9.71 APOA1 INS SERPINA3
4 high-density lipoprotein particle GO:0034364 9.54 APOA1 APOE CETP
5 endosome lumen GO:0031904 9.51 APOB INS
6 very-low-density lipoprotein particle GO:0034361 9.5 APOA1 APOB APOE
7 ATP-binding cassette (ABC) transporter complex GO:0043190 9.46 ABCG5 ABCG8
8 endocytic vesicle lumen GO:0071682 9.43 APOA1 APOB APOE
9 discoidal high-density lipoprotein particle GO:0034365 9.4 APOA1 APOE
10 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOE
11 chylomicron GO:0042627 9.13 APOA1 APOB APOE
12 intermediate-density lipoprotein particle GO:0034363 8.8 APOA1 APOB APOE
13 extracellular region GO:0005576 10.13 APOA1 APOB APOE CCK CETP IL10
14 extracellular space GO:0005615 10.09 APOA1 APOB APOE CCK CETP IL10

Biological processes related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.97 APOA1 APOB APOE INS
2 response to drug GO:0042493 9.95 ABCB4 ABCG5 ABCG8 APOA1 IL10 UGT1A1
3 negative regulation of inflammatory response GO:0050728 9.88 APOA1 APOE IL10
4 response to organic substance GO:0010033 9.88 APOB IL10 UGT1A1
5 regulation of lipid metabolic process GO:0019216 9.87 ABCB4 APOA1 SERPINA3
6 response to nutrient GO:0007584 9.85 ABCG5 ABCG8 APOA1 UGT1A1
7 retinoid metabolic process GO:0001523 9.83 APOA1 APOB APOE
8 phospholipid transport GO:0015914 9.81 ABCG8 APOA1 CETP
9 lipid homeostasis GO:0055088 9.8 ABCB4 APOE CETP
10 acute-phase response GO:0006953 9.8 INS SERPINA3 UGT1A1
11 triglyceride homeostasis GO:0070328 9.77 APOA1 APOE CETP
12 cholesterol transport GO:0030301 9.77 APOA1 APOB CETP
13 triglyceride catabolic process GO:0019433 9.76 APOA1 APOB APOE
14 lipoprotein metabolic process GO:0042157 9.73 APOA1 APOB APOE
15 steroid metabolic process GO:0008202 9.73 APOA1 APOB APOE CETP SOAT1 UGT1A1
16 cholesterol metabolic process GO:0008203 9.72 APOA1 APOB APOE CETP SOAT1
17 fatty acid homeostasis GO:0055089 9.71 APOE INS
18 reverse cholesterol transport GO:0043691 9.71 APOA1 APOE CETP
19 regulation of cholesterol metabolic process GO:0090181 9.7 APOE TTC39B
20 high-density lipoprotein particle assembly GO:0034380 9.7 APOA1 APOE
21 high-density lipoprotein particle remodeling GO:0034375 9.7 APOA1 APOE CETP
22 lipid transport GO:0006869 9.7 ABCB4 ABCG5 ABCG8 APOA1 APOB APOE
23 phosphatidylcholine metabolic process GO:0046470 9.69 CETP MECP2
24 phospholipid efflux GO:0033700 9.69 APOA1 APOE
25 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.69 APOA1 IL10
26 positive regulation of lipid biosynthetic process GO:0046889 9.69 APOA1 APOE INS
27 very-low-density lipoprotein particle assembly GO:0034379 9.68 APOB SOAT1
28 high-density lipoprotein particle clearance GO:0034384 9.68 APOA1 APOE
29 intestinal cholesterol absorption GO:0030299 9.68 ABCG5 ABCG8
30 phospholipid homeostasis GO:0055091 9.68 APOA1 CETP
31 positive regulation of cholesterol esterification GO:0010873 9.67 APOA1 APOE
32 chylomicron remnant clearance GO:0034382 9.67 APOB APOE
33 low-density lipoprotein particle remodeling GO:0034374 9.67 APOB APOE CETP
34 regulation of Cdc42 protein signal transduction GO:0032489 9.66 APOA1 APOE
35 regulation of cholesterol transport GO:0032374 9.66 APOA1 APOE
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 APOA1 IL10
37 very-low-density lipoprotein particle clearance GO:0034447 9.65 APOB APOE
38 glucocorticoid metabolic process GO:0008211 9.64 APOA1 MECP2
39 positive regulation of dendritic spine maintenance GO:1902952 9.63 APOE INS
40 chylomicron assembly GO:0034378 9.63 APOA1 APOB APOE
41 lipoprotein catabolic process GO:0042159 9.62 APOB APOE
42 regulation of cholesterol efflux GO:0010874 9.61 CETP TTC39B
43 very-low-density lipoprotein particle remodeling GO:0034372 9.61 APOA1 APOE CETP
44 negative regulation of intestinal cholesterol absorption GO:0045796 9.58 ABCG5 ABCG8
45 chylomicron remodeling GO:0034371 9.58 APOA1 APOB APOE
46 negative regulation of intestinal phytosterol absorption GO:0010949 9.57 ABCG5 ABCG8
47 lipoprotein biosynthetic process GO:0042158 9.54 APOA1 APOB APOE
48 cholesterol efflux GO:0033344 9.43 ABCG5 ABCG8 APOA1 APOB APOE SOAT1
49 cholesterol homeostasis GO:0042632 9.23 ABCG5 ABCG8 APOA1 APOB APOE CETP
50 lipid metabolic process GO:0006629 10.08 ABCB4 APOA1 APOB APOE CETP SOAT1

Molecular functions related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.65 APOA1 APOB APOE
2 lipid binding GO:0008289 9.63 APOA1 APOE CETP
3 hormone activity GO:0005179 9.61 CCK INS MLN
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.5 ABCB4 ABCG5 ABCG8
5 low-density lipoprotein particle receptor binding GO:0050750 9.49 APOB APOE
6 cholesterol binding GO:0015485 9.46 APOA1 APOE CETP SOAT1
7 phospholipid transporter activity GO:0005548 9.43 ABCB4 APOA1 CETP
8 lipoprotein particle binding GO:0071813 9.4 APOA1 APOE
9 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.37 APOA1 APOE
10 lipid transporter activity GO:0005319 9.26 APOA1 APOB APOE CETP
11 cholesterol transporter activity GO:0017127 9.1 ABCG5 ABCG8 APOA1 APOB APOE CETP

Sources for Gallbladder Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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