MCID: GLL012
MIFTS: 29

Gallbladder Melanoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Gallbladder Melanoma

MalaCards integrated aliases for Gallbladder Melanoma:

Name: Gallbladder Melanoma 12 15 71
Malignant Melanoma of Gallbladder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8167
NCIt 49 C5735
UMLS 71 C1333749

Summaries for Gallbladder Melanoma

MalaCards based summary : Gallbladder Melanoma, also known as malignant melanoma of gallbladder, is related to melanoma and melanoma in congenital melanocytic nevus. An important gene associated with Gallbladder Melanoma is MLANA (Melan-A), and among its related pathways/superpathways are NF-kappaB Signaling and Pathways in cancer. Affiliated tissues include skin, uterus and eye, and related phenotypes are cellular and behavior/neurological

Related Diseases for Gallbladder Melanoma

Diseases related to Gallbladder Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 melanoma 28.7 WNT5A PMEL PDGFRA MLANA MITF IL2
2 melanoma in congenital melanocytic nevus 10.4 PMEL MLANA
3 halo nevi 10.4 PMEL MLANA
4 lentigo maligna melanoma 10.4 MLANA MITF
5 uterus perivascular epithelioid cell tumor 10.4 MLANA MITF
6 perivascular epithelioid cell tumor 10.4 MLANA MITF
7 epithelioid cell melanoma 10.4 MLANA MITF
8 pigmented basal cell carcinoma 10.4 MLANA MITF
9 vulvar melanoma 10.3 MLANA MAP2K7
10 benign perivascular tumor 10.3 PECAM1 MLANA
11 intravascular fasciitis 10.3 PECAM1 MLANA
12 mixed cell uveal melanoma 10.3 PMEL MLANA
13 juvenile xanthogranuloma 10.3 PMEL MLANA
14 angiolipoma 10.3 PECAM1 MLANA
15 waardenburg syndrome type 4 10.3 SOX10 MITF
16 lateral displacement of eye 10.3 SOX10 MITF
17 waardenburg syndrome, type 2b 10.3 SOX10 MITF
18 cervical mucinous adenocarcinoma 10.3 MLANA MAP2K7
19 glomangiomatosis 10.3 PECAM1 MLANA
20 epithelioid malignant peripheral nerve sheath tumor 10.3 SOX10 MLANA
21 waardenburg syndrome, type 4c 10.2 SOX10 MITF
22 waardenburg syndrome, type 2d 10.2 SOX10 MITF
23 waardenburg syndrome, type 2c 10.2 SOX10 MITF
24 albinism, ocular, with late-onset sensorineural deafness 10.2 SOX10 MITF
25 nodular malignant melanoma 10.2 MLANA MITF MAP2K7
26 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 10.1 SOX10 MITF
27 cutaneous fibrous histiocytoma 10.1 MLANA MITF
28 dermis tumor 10.1 PECAM1 MLANA MITF
29 small intestine leiomyoma 10.1 PDGFRA MLANA
30 cardiovascular cancer 10.1 PECAM1 MLANA MITF
31 waardenburg syndrome, type 2a 10.1 SOX10 MITF
32 vascular cancer 10.1 PECAM1 MLANA MITF
33 malignant choroid melanoma 10.1 SOX10 MLANA MITF
34 waardenburg syndrome, type 3 10.1 SOX10 MITF
35 waardenburg syndrome, type 4b 10.1 SOX10 PMEL MITF
36 waardenburg syndrome, type 2e 10.1 SOX10 PMEL MITF
37 tietz albinism-deafness syndrome 10.1 SOX10 PMEL MITF
38 clear cell sarcoma 10.1 SOX10 MLANA MITF
39 waardenburg syndrome, type 4a 10.1 SOX10 PMEL MITF
40 undifferentiated pleomorphic sarcoma 10.1 PDGFRA MLANA
41 angiokeratoma circumscriptum 10.1 SLC2A1 PECAM1
42 skin hemangioma 10.1 SLC2A1 PECAM1
43 uterus leiomyosarcoma 10.1 PDGFRA MLANA
44 heart leiomyosarcoma 10.1 PECAM1 PDGFRA
45 pulmonary vein stenosis 10.0 PECAM1 PDGFRA
46 amelanotic melanoma 10.0 MLANA MITF
47 cholecystitis 10.0
48 skin melanoma 9.9 PMEL MLANA MITF MAP2K7
49 capillary hemangioma 9.9 SLC2A1 PECAM1
50 malignant spindle cell melanoma 9.9 SOX10 PMEL MLANA MITF

Graphical network of the top 20 diseases related to Gallbladder Melanoma:



Diseases related to Gallbladder Melanoma

Symptoms & Phenotypes for Gallbladder Melanoma

MGI Mouse Phenotypes related to Gallbladder Melanoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 G6PD IL2 MAP2K7 MITF PDGFRA PECAM1
2 behavior/neurological MP:0005386 10.03 IL2 MAP2K7 MITF PDGFRA PMEL SLC2A1
3 homeostasis/metabolism MP:0005376 9.96 G6PD IL2 MAP2K7 MITF PDGFRA PECAM1
4 hematopoietic system MP:0005397 9.92 G6PD IL2 MITF PDGFRA PECAM1 PMEL
5 endocrine/exocrine gland MP:0005379 9.91 IL2 MAP2K7 MITF PDGFRA SOX10 VSIR
6 no phenotypic analysis MP:0003012 9.7 IL2 MITF MLANA PDGFRA PMEL SLC2A1
7 pigmentation MP:0001186 9.35 MITF MLANA PDGFRA PMEL SOX10
8 respiratory system MP:0005388 9.1 IL2 PDGFRA PECAM1 SOX10 VSIR WNT5A

Drugs & Therapeutics for Gallbladder Melanoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Melanoma

Genetic Tests for Gallbladder Melanoma

Anatomical Context for Gallbladder Melanoma

MalaCards organs/tissues related to Gallbladder Melanoma:

40
Skin, Uterus, Eye, Heart, Small Intestine

Publications for Gallbladder Melanoma

Articles related to Gallbladder Melanoma:

(show all 16)
# Title Authors PMID Year
1
Complete response for 36 months after BRAF and MEK inhibitor therapy for locally advanced gallbladder melanoma. 61
31115206 2019
2
Metastatic Gallbladder Melanoma Presenting as Acute Emphysematous Cholecystitis. 61
29853906 2018
3
Curcumin molecular targets in obesity and obesity-related cancers. 61
22335582 2012
4
Primary gallbladder melanoma in dysplastic nevus syndrome: report of case and literature review. 61
22287410 2011
5
Primary malignant melanoma of gallbladder. 61
21263401 2011
6
Malignant melanoma of the gallbladder: a report of two cases and review of the literature. 61
18060465 2008
7
Isolated metastatic melanoma to the gallbladder: is laparoscopic cholecystectomy indicated?: a case report and review of the literature. 61
17450099 2007
8
Surgical management of melanoma of the gallbladder: a report of 13 cases and review of the literature. 61
17368297 2007
9
Primary melanoma of the gallbladder: does it exist? Report of a case and review of the literature. 61
16830389 2006
10
[Secondary malignant melanoma of the gallbladder. A contribution to the differential diagnosis of pigmented lesions of the gallbladder]. 61
15011002 2004
11
Metastatic melanoma in the gallbladder: report of a case. 61
12616378 2003
12
Metastatic malignant melanoma of the gallbladder: a case report and review of the literature. 61
12459652 2002
13
Primary malignant melanoma of the gallbladder in dysplastic naevus syndrome. 61
11253118 2001
14
Gallbladder melanoma mimicking acute acalculous cholecystitis. 61
11265063 2000
15
Melanoma of the gallbladder: a review of cases seen at Duke University Medical Center. 61
9921971 1999
16
[Gallbladder melanoma]. 61
5398673 1969

Variations for Gallbladder Melanoma

Expression for Gallbladder Melanoma

Search GEO for disease gene expression data for Gallbladder Melanoma.

Pathways for Gallbladder Melanoma

GO Terms for Gallbladder Melanoma

Cellular components related to Gallbladder Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 SLC2A1 PMEL MLANA

Biological processes related to Gallbladder Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.76 WNT5A SOX10 MITF IL2
2 positive regulation of gene expression GO:0010628 9.67 WNT5A VSIR SOX10 MITF
3 positive regulation of protein phosphorylation GO:0001934 9.61 WNT5A PECAM1 IL2
4 melanocyte differentiation GO:0030318 9.4 SOX10 MITF
5 response to osmotic stress GO:0006970 9.32 SLC2A1 MAP2K7
6 morphogenesis of an epithelium GO:0002009 9.26 WNT5A SOX10
7 digestive tract morphogenesis GO:0048546 9.16 WNT5A SOX10
8 positive regulation of regulatory T cell differentiation GO:0045591 8.96 VSIR IL2
9 wound healing GO:0042060 8.8 WNT5A PECAM1 PDGFRA

Molecular functions related to Gallbladder Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 VSIR SOX10 SLC2A1 PMEL G6PD

Sources for Gallbladder Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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