MCID: GLL012
MIFTS: 25

Gallbladder Melanoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Gallbladder Melanoma

MalaCards integrated aliases for Gallbladder Melanoma:

Name: Gallbladder Melanoma 12 15 71
Malignant Melanoma of Gallbladder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8167
NCIt 50 C5735
UMLS 71 C1333749

Summaries for Gallbladder Melanoma

MalaCards based summary : Gallbladder Melanoma, also known as malignant melanoma of gallbladder, is related to melanoma and melanoacanthoma. An important gene associated with Gallbladder Melanoma is MLANA (Melan-A), and among its related pathways/superpathways are Pathways in cancer and NF-kappaB Signaling. Related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Gallbladder Melanoma

Diseases related to Gallbladder Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 melanoma 29.0 WNT5A SOX10 PMEL MLANA MITF IL2
2 melanoacanthoma 10.3 PMEL MLANA
3 halo nevi 10.2 PMEL MLANA
4 diffuse meningeal melanocytosis 10.2 PMEL MLANA
5 lentigo maligna melanoma 10.2 MLANA MITF
6 pigmented basal cell carcinoma 10.2 MLANA MITF
7 epithelioid cell melanoma 10.2 MLANA MITF
8 uterus perivascular epithelioid cell tumor 10.2 MLANA MITF
9 perivascular epithelioid cell tumor 10.2 MLANA MITF
10 juvenile xanthogranuloma 10.2 PMEL MLANA
11 glomangiosarcoma 10.2 PECAM1 MLANA
12 nodular malignant melanoma 10.2 MLANA MITF
13 benign perivascular tumor 10.2 PECAM1 MLANA
14 skin sarcoma 10.2 PECAM1 MLANA
15 intravascular fasciitis 10.2 PECAM1 MLANA
16 glomangiomatosis 10.2 PECAM1 MLANA
17 conjunctival pigmentation 10.2 SOX10 MLANA
18 angiolipoma 10.2 PECAM1 MLANA
19 malignant anus melanoma 10.1 MLANA IL2
20 conjunctival nevus 10.1 SOX10 MLANA
21 waardenburg syndrome, type 2c 10.1 SOX10 MITF
22 waardenburg syndrome, type 2b 10.1 SOX10 MITF
23 epithelioid malignant peripheral nerve sheath tumor 10.1 SOX10 MLANA
24 waardenburg syndrome type 4 10.1 SOX10 MITF
25 nasal cavity adenocarcinoma 10.1 SOX10 MLANA
26 fasciitis 10.1 MITF IL2
27 mesenchymal cell neoplasm 10.1 PECAM1 MLANA
28 waardenburg syndrome, type 2d 10.1 SOX10 MITF
29 connective tissue benign neoplasm 10.1 PECAM1 MLANA
30 waardenburg syndrome, type 4c 10.1 SOX10 MITF
31 waardenburg syndrome, type 3 10.1 SOX10 MITF
32 tietz albinism-deafness syndrome 10.1 SOX10 MITF
33 waardenburg syndrome, type 2a 10.1 SOX10 MITF
34 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 10.0 SOX10 MITF
35 lipomatosis, multiple 10.0 PECAM1 MLANA
36 angiomyolipoma 10.0 MLANA MITF
37 waardenburg syndrome, type 1 10.0 SOX10 MITF
38 waardenburg syndrome, type 4a 10.0 SOX10 MITF
39 mucosal melanoma 10.0 MITF IL2
40 vascular cancer 10.0 PECAM1 MLANA MITF
41 pigmentation disease 10.0 MITF G6PD
42 cholecystitis 10.0
43 malignant choroid melanoma 10.0 SOX10 MLANA MITF
44 large congenital melanocytic nevus 10.0 SOX10 MLANA MITF
45 clear cell sarcoma 10.0 SOX10 MLANA MITF
46 neurofibroma 10.0 SOX10 MLANA MITF
47 waardenburg syndrome, type 4b 9.9 SOX10 PMEL MITF
48 waardenburg syndrome, type 2e 9.9 SOX10 PMEL MITF
49 autoimmune disease of skin and connective tissue 9.9 PMEL MITF IL2
50 plague 9.9 PECAM1 IL2

Graphical network of the top 20 diseases related to Gallbladder Melanoma:



Diseases related to Gallbladder Melanoma

Symptoms & Phenotypes for Gallbladder Melanoma

MGI Mouse Phenotypes related to Gallbladder Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 G6PD IL2 MITF PECAM1 SLC2A1 SOX10
2 homeostasis/metabolism MP:0005376 9.76 G6PD IL2 MITF PECAM1 PMEL SLC2A1
3 no phenotypic analysis MP:0003012 9.43 IL2 MITF MLANA PMEL SLC2A1 SOX10
4 pigmentation MP:0001186 8.92 MITF MLANA PMEL SOX10

Drugs & Therapeutics for Gallbladder Melanoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Melanoma

Genetic Tests for Gallbladder Melanoma

Anatomical Context for Gallbladder Melanoma

Publications for Gallbladder Melanoma

Articles related to Gallbladder Melanoma:

(show all 16)
# Title Authors PMID Year
1
Complete response for 36 months after BRAF and MEK inhibitor therapy for locally advanced gallbladder melanoma. 61
31115206 2019
2
Metastatic Gallbladder Melanoma Presenting as Acute Emphysematous Cholecystitis. 61
29853906 2018
3
Curcumin molecular targets in obesity and obesity-related cancers. 61
22335582 2012
4
Primary gallbladder melanoma in dysplastic nevus syndrome: report of case and literature review. 61
22287410 2011
5
Primary malignant melanoma of gallbladder. 61
21263401 2011
6
Malignant melanoma of the gallbladder: a report of two cases and review of the literature. 61
18060465 2008
7
Isolated metastatic melanoma to the gallbladder: is laparoscopic cholecystectomy indicated?: a case report and review of the literature. 61
17450099 2007
8
Surgical management of melanoma of the gallbladder: a report of 13 cases and review of the literature. 61
17368297 2007
9
Primary melanoma of the gallbladder: does it exist? Report of a case and review of the literature. 61
16830389 2006
10
[Secondary malignant melanoma of the gallbladder. A contribution to the differential diagnosis of pigmented lesions of the gallbladder]. 61
15011002 2004
11
Metastatic melanoma in the gallbladder: report of a case. 61
12616378 2003
12
Metastatic malignant melanoma of the gallbladder: a case report and review of the literature. 61
12459652 2002
13
Primary malignant melanoma of the gallbladder in dysplastic naevus syndrome. 61
11253118 2001
14
Gallbladder melanoma mimicking acute acalculous cholecystitis. 61
11265063 2000
15
Melanoma of the gallbladder: a review of cases seen at Duke University Medical Center. 61
9921971 1999
16
[Gallbladder melanoma]. 61
5398673 1969

Variations for Gallbladder Melanoma

Expression for Gallbladder Melanoma

Search GEO for disease gene expression data for Gallbladder Melanoma.

Pathways for Gallbladder Melanoma

Pathways related to Gallbladder Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.18 WNT5A SLC2A1 MITF IL2
2 12.01 PECAM1 MLANA IL2
3 10.87 SOX10 MITF
4 10.16 SLC2A1 G6PD
5 9.4 SLC2A1 G6PD

GO Terms for Gallbladder Melanoma

Cellular components related to Gallbladder Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 SLC2A1 PMEL MLANA

Biological processes related to Gallbladder Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.5 WNT5A PECAM1 IL2
2 morphogenesis of an epithelium GO:0002009 9.26 WNT5A SOX10
3 negative regulation of apoptotic process GO:0043066 9.26 WNT5A SOX10 MITF IL2
4 melanocyte differentiation GO:0030318 9.16 SOX10 MITF
5 digestive tract morphogenesis GO:0048546 8.62 WNT5A SOX10

Sources for Gallbladder Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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