MCID: GLL004
MIFTS: 22

Gallbladder Papillary Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Papillary Carcinoma

MalaCards integrated aliases for Gallbladder Papillary Carcinoma:

Name: Gallbladder Papillary Carcinoma 12 15
Papillary Carcinoma of the Gallbladder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7221
NCIt 50 C5743
UMLS 70 C1333753

Summaries for Gallbladder Papillary Carcinoma

Disease Ontology : 12 A papillary carcioma that is located in the gallbladder.

MalaCards based summary : Gallbladder Papillary Carcinoma, also known as papillary carcinoma of the gallbladder, is related to papillary carcinoma and gallbladder cancer. An important gene associated with Gallbladder Papillary Carcinoma is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and NF-kappaB Signaling. Affiliated tissues include gallbladder and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Gallbladder Papillary Carcinoma

Diseases related to Gallbladder Papillary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 papillary carcinoma 10.3
2 gallbladder cancer 10.1
3 eccrine mixed tumor of skin 10.0 PECAM1 CEACAM5
4 liver leiomyoma 10.0 PECAM1 CEACAM5
5 thyroid angiosarcoma 10.0 PECAM1 CEACAM5
6 colonic benign neoplasm 9.9 PTGS2 CEACAM5
7 actinic keratosis 9.9 PTGS2 CEACAM5
8 intestinal benign neoplasm 9.9 PTGS2 CEACAM5
9 acquired hemangioma 9.9 PECAM1 PDPN
10 gastrointestinal system benign neoplasm 9.9 PTGS2 CEACAM5
11 hemangioma 9.9 PECAM1 PDPN
12 hobnail hemangioma 9.9 PECAM1 PDPN
13 esophageal adenoid cystic carcinoma 9.9 PDPN CEACAM5
14 capillary lymphangioma 9.9 PECAM1 PDPN
15 inguinal hernia 9.9 PTGS2 PECAM1
16 angiosarcoma 9.8 PECAM1 PDPN
17 lymphangiosarcoma 9.8 PECAM1 PDPN
18 xanthogranulomatous cholecystitis 9.8 PDPN CEACAM5
19 eccrine papillary adenocarcinoma 9.8 PDPN CEACAM5
20 colorectal adenocarcinoma 9.8 PTGS2 CEACAM5
21 gorham's disease 9.8 PECAM1 PDPN
22 eccrine papillary adenoma 9.8 PDPN CEACAM5
23 cystic lymphangioma 9.8 PECAM1 PDPN
24 mucinous cystadenocarcinoma 9.8 PDPN CEACAM5
25 cystadenocarcinoma 9.8 PDPN CEACAM5
26 capillary hemangioma 9.8 PECAM1 PDPN
27 signet ring cell adenocarcinoma 9.8 PDPN CEACAM5
28 microinvasive gastric cancer 9.8 PDPN CEACAM5
29 vascular cancer 9.8 PECAM1 PDPN
30 keratocystic odontogenic tumor 9.8 PTGS2 PDPN
31 neuritis 9.8 PTGS2 PECAM1
32 hemangioblastoma 9.8 PECAM1 PDPN
33 oligodendroglioma 9.7 PTGS2 PECAM1
34 gallbladder disease 9.7 PDPN CEACAM5
35 mesothelioma, malignant 9.7 PDPN CEACAM5
36 gastric adenocarcinoma 9.7 PTGS2 CEACAM5
37 cell type benign neoplasm 9.7 PTGS2 PECAM1 CEACAM5
38 lung cancer susceptibility 3 9.6 PTGS2 PECAM1 CEACAM5
39 skin carcinoma 9.6 PTGS2 PECAM1 CEACAM5
40 colonic lymphangioma 9.6 PECAM1 PDPN CEACAM5
41 lymphangitis 9.6 PECAM1 PDPN CEACAM5
42 benign peritoneal mesothelioma 9.6 PECAM1 PDPN CEACAM5
43 benign mesothelioma 9.6 PECAM1 PDPN CEACAM5
44 cardiovascular organ benign neoplasm 9.6 PECAM1 PDPN CEACAM5
45 cholangiocarcinoma 9.6 PTGS2 CEACAM5
46 squamous cell carcinoma 9.5 PTGS2 PDPN CEACAM5
47 lymphangioma 9.3 PTGS2 PECAM1 PDPN CEACAM5

Graphical network of the top 20 diseases related to Gallbladder Papillary Carcinoma:



Diseases related to Gallbladder Papillary Carcinoma

Symptoms & Phenotypes for Gallbladder Papillary Carcinoma

GenomeRNAi Phenotypes related to Gallbladder Papillary Carcinoma according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.97 PECAM1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.97 PTGS2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.97 PECAM1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.97 PTGS2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.97 PTGS2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.97 PECAM1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.97 PECAM1 PTGS2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.97 PTGS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.97 PECAM1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.97 PECAM1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.97 PECAM1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.97 PTGS2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.97 PECAM1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.97 PECAM1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.97 PTGS2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.97 PECAM1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.97 PECAM1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.97 PECAM1 PTGS2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.97 PECAM1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.97 PTGS2

Drugs & Therapeutics for Gallbladder Papillary Carcinoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Papillary Carcinoma

Genetic Tests for Gallbladder Papillary Carcinoma

Anatomical Context for Gallbladder Papillary Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Papillary Carcinoma:

19
Gallbladder

MalaCards organs/tissues related to Gallbladder Papillary Carcinoma:

40
Lymph Node

Publications for Gallbladder Papillary Carcinoma

Articles related to Gallbladder Papillary Carcinoma:

# Title Authors PMID Year
1
Gallbladder carcinoma with a large monolocular cystic cancerous component. 61
22870100 2010
2
Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery. 61
20651971 2009
3
Papillary carcinoma of the gallbladder and anomalous pancreatico-biliary junction. Report of three cases and review of the literature. 61
16001624 2005
4
Intraluminal papillary carcinoma of the gallbladder: prognostic value of computed tomography and sonography. 61
3290037 1988
5
Papillary carcinoma of the gallbladder. The importance of lymph node dissection in early cases. 61
14008097 1961

Variations for Gallbladder Papillary Carcinoma

Expression for Gallbladder Papillary Carcinoma

Search GEO for disease gene expression data for Gallbladder Papillary Carcinoma.

Pathways for Gallbladder Papillary Carcinoma

Pathways related to Gallbladder Papillary Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 PECAM1 PDPN CEACAM5
2 11.65 PTGS2 PECAM1 CEACAM5
3
Show member pathways
11.41 PECAM1 CEACAM5
4 10.75 PTGS2 PECAM1 PDPN

GO Terms for Gallbladder Papillary Carcinoma

Cellular components related to Gallbladder Papillary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.62 PDPN CEACAM5

Biological processes related to Gallbladder Papillary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.32 PECAM1 CEACAM5
2 cell-cell adhesion GO:0098609 9.26 PECAM1 PDPN
3 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.16 PECAM1 CEACAM5
4 negative regulation of apoptotic process GO:0043066 9.13 PTGS2 PDPN CEACAM5
5 maintenance of permeability of blood-brain barrier GO:0035633 8.62 PTGS2 PECAM1

Molecular functions related to Gallbladder Papillary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.8 PTGS2 PECAM1 CEACAM5

Sources for Gallbladder Papillary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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