Gallbladder Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Gallbladder Sarcoma

MalaCards integrated aliases for Gallbladder Sarcoma:

Name: Gallbladder Sarcoma ¹² ¹⁵ ⁷³

Malignant Mesenchymal Tumor of Gallbladder ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4058

NCIt ⁵⁰ C5736

UMLS ⁷³ C1333757

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Summaries for Gallbladder Sarcoma

Disease Ontology : ¹² A sarcoma that is located in the gallbladder.

MalaCards based summary : Gallbladder Sarcoma, also known as malignant mesenchymal tumor of gallbladder, is related to botryoid rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Gallbladder Sarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Developmental Biology and Hematopoietic cell lineage. Affiliated tissues include the gallbladder, and related phenotype is muscle.

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Related Diseases for Gallbladder Sarcoma

Diseases related to Gallbladder Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)

#	Related Disease	Score	Top Affiliating Genes
1	botryoid rhabdomyosarcoma	30.2	DES MYOD1
2	rhabdomyosarcoma	29.2	DES MYOD1 MYOG
3	gallbladder rhabdomyosarcoma	11.0
4	gallbladder angiosarcoma	11.0
5	gallbladder leiomyosarcoma	11.0
6	cervical polyp	10.5	DES MYOD1
7	mesenchymoma	10.5	DES MYOD1
8	spindle cell rhabdomyosarcoma	10.4	DES MYOD1
9	horner's syndrome	10.4	DES MYOD1
10	malignant fibrous histiocytoma of bone	10.4	DES MYOD1
11	undifferentiated embryonal sarcoma of the liver	10.4	MYOD1 MYOG
12	rhabdoid cancer	10.4	DES MYOD1
13	conventional leiomyosarcoma	10.4	MYOD1 MYOG
14	malignant fibroxanthoma	10.3	DES MYOD1
15	adult fibrosarcoma	10.3	MYOD1 MYOG
16	ischemic fasciitis	10.3	CD34 DES
17	pseudosarcomatous fibromatosis	10.2	DES MYOG
18	congenital epulis	10.2	CD34 DES
19	extraosseous ewing's sarcoma	10.2	MYOD1 MYOG
20	glomangioma	10.2	CD34 DES
21	alveolar soft part sarcoma	10.2	DES MYOD1
22	skeletal muscle cancer	10.1	MYOD1 MYOG
23	prostate embryonal rhabdomyosarcoma	10.0	KIT MYOD1
24	intraneural perineurioma	10.0	CD34 KRT18
25	prostate rhabdomyosarcoma	10.0	KIT MYOD1
26	ovarian fibrothecoma	10.0	DES KIT
27	pulmonary vein stenosis	9.9	DES KIT
28	cystic nephroma	9.9	DES KIT
29	gallbladder leiomyoma	9.9	CD34 KIT
30	lung leiomyosarcoma	9.9	CD34 KIT
31	liver leiomyoma	9.9	CD34 KIT
32	deep leiomyoma	9.9	CD34 KIT
33	extracutaneous mastocytoma	9.9	CD34 KIT
34	small intestine leiomyosarcoma	9.9	CD34 KIT
35	small intestinal sarcoma	9.9	CD34 KIT
36	perivascular epithelioid cell tumor	9.9	DES KIT
37	prostate leiomyosarcoma	9.9	CD34 KIT
38	adenosarcoma	9.9	DES KIT
39	breast rhabdomyosarcoma	9.9	DES MYOD1 MYOG
40	diffuse cutaneous mastocytosis	9.9	CD34 KIT
41	inflammatory leiomyosarcoma	9.9	DES MYOD1 MYOG
42	sarcomatoid squamous cell skin carcinoma	9.9	CD34 KIT
43	gastric leiomyosarcoma	9.9	CD34 KIT
44	medullomyoblastoma	9.9	DES MYOD1 MYOG
45	embryonal rhabdomyosarcoma	9.9	DES MYOD1 MYOG
46	breast angiosarcoma	9.9	CD34 KIT
47	smooth muscle tumor	9.9	DES KIT
48	rhabdomyosarcoma 2	9.9	DES MYOD1 MYOG
49	plexiform schwannoma	9.9	CD34 KIT
50	conventional fibrosarcoma	9.9	CD34 KIT

Graphical network of the top 20 diseases related to Gallbladder Sarcoma:

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Symptoms & Phenotypes for Gallbladder Sarcoma

MGI Mouse Phenotypes related to Gallbladder Sarcoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	8.92	DES KIT MYOD1 MYOG

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Drugs & Therapeutics for Gallbladder Sarcoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Sarcoma

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Genetic Tests for Gallbladder Sarcoma

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Anatomical Context for Gallbladder Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Sarcoma:

¹⁹

The Gallbladder

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Publications for Gallbladder Sarcoma

Articles related to Gallbladder Sarcoma:

#	Title	Authors	Year
1	Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. ( 19194282 )	Al-Daraji W.I....Fanburg-Smith J.C.	2009
2	Gallbladder sarcoma: a clinicopathological study of seven cases from the UK and Austria with emphasis on morphological subtypes. ( 18618258 )	Husain E.A....Al-Daraji W.I.	2009

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Genes for Gallbladder Sarcoma

Genes related to Gallbladder Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYOD1	Myogenic Differentiation 1	Protein Coding	21.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	DES	Desmin	Protein Coding	16.57	GeneCards inferred via : Publications (show sections)
3	KRT18	Keratin 18	Protein Coding	14.9	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.94	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MYOG	Myogenin	Protein Coding	11.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	CD34	CD34 Molecule	Protein Coding	3.58	DISEASES inferred ¹⁵

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Variations for Gallbladder Sarcoma

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Expression for Gallbladder Sarcoma

Search GEO for disease gene expression data for Gallbladder Sarcoma.

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Pathways for Gallbladder Sarcoma

Pathways related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	12.92	KIT KRT18 MYOD1 MYOG
2	Hematopoietic cell lineage ³⁷	11.35	CD34 KIT
3	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.22	CD34 KIT
4	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.13	CD34 KIT
5	Myogenesis ⁶⁶ Show member pathways CDO in myogenesis ⁶⁶	10.92	MYOD1 MYOG
6	C-MYB transcription factor network ¹	10.69	CD34 KIT MYOD1
7	B Cell Development Pathways ⁶⁵	10.68	CD34 KIT

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GO Terms for Gallbladder Sarcoma

Cellular components related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell periphery	GO:0071944	8.62	CD34 KRT18

Biological processes related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	hemopoiesis	GO:0030097	9.51	CD34 KIT
2	skeletal muscle tissue development	GO:0007519	9.49	MYOD1 MYOG
3	skeletal muscle cell differentiation	GO:0035914	9.48	MYOD1 MYOG
4	cellular response to estradiol stimulus	GO:0071392	9.46	MYOD1 MYOG
5	skeletal muscle fiber development	GO:0048741	9.43	MYOD1 MYOG
6	positive regulation of muscle cell differentiation	GO:0051149	9.4	MYOD1 MYOG
7	positive regulation of myoblast differentiation	GO:0045663	9.37	MYOD1 MYOG
8	myoblast differentiation	GO:0045445	9.32	MYOD1 MYOG
9	positive regulation of myoblast fusion	GO:1901741	9.26	MYOD1 MYOG
10	myotube differentiation	GO:0014902	9.16	MYOD1 MYOG
11	positive regulation of skeletal muscle fiber development	GO:0048743	8.96	MYOD1 MYOG
12	muscle cell fate commitment	GO:0042693	8.62	MYOD1 MYOG

Molecular functions related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	GO:0003705	9.26	MYOD1 MYOG
2	core promoter binding	GO:0001047	9.16	MYOD1 MYOG
3	chromatin DNA binding	GO:0031490	8.96	MYOD1 MYOG
4	E-box binding	GO:0070888	8.62	MYOD1 MYOG

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