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MCID: GLL021
MIFTS: 30

Gallbladder Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Gallbladder Sarcoma

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MalaCards integrated aliases for Gallbladder Sarcoma:

Name: Gallbladder Sarcoma 12 15 73
Malignant Mesenchymal Tumor of Gallbladder 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4058
NCIt 50 C5736
UMLS 73 C1333757
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Summaries for Gallbladder Sarcoma

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Disease Ontology : 12 A sarcoma that is located in the gallbladder.

MalaCards based summary : Gallbladder Sarcoma, also known as malignant mesenchymal tumor of gallbladder, is related to botryoid rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Gallbladder Sarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Developmental Biology and Hematopoietic cell lineage. Affiliated tissues include lung, liver and bone, and related phenotype is muscle.

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Related Diseases for Gallbladder Sarcoma

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Diseases related to Gallbladder Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 botryoid rhabdomyosarcoma 29.9 DES MYOD1
2 rhabdomyosarcoma 29.6 DES MYOD1 MYOG
3 gallbladder rhabdomyosarcoma 11.1
4 gallbladder angiosarcoma 11.1
5 gallbladder leiomyosarcoma 11.1
6 mesenchymoma 10.2 DES MYOD1
7 malignant triton tumor 10.1 DES MYOD1
8 spindle cell rhabdomyosarcoma 10.1 DES MYOD1
9 malignant fibrous histiocytoma of bone 10.1 DES MYOD1
10 horner's syndrome 10.1 DES MYOD1
11 breast rhabdomyosarcoma 10.1 MYOD1 MYOG
12 liposarcoma 10.1 CD34 DES
13 undifferentiated embryonal sarcoma of the liver 10.1 MYOD1 MYOG
14 conventional leiomyosarcoma 10.1 MYOD1 MYOG
15 malignant fibroxanthoma 10.1 DES MYOD1
16 rhabdoid tumor predisposition syndrome 1 10.1 DES MYOD1
17 ischemic fasciitis 10.1 CD34 DES
18 congenital epulis 10.1 CD34 DES
19 extraosseous ewing's sarcoma 10.1 MYOD1 MYOG
20 alveolar soft part sarcoma 10.0 DES MYOD1
21 skeletal muscle cancer 10.0 MYOD1 MYOG
22 prostate embryonal rhabdomyosarcoma 10.0 KIT MYOD1
23 prostate rhabdomyosarcoma 10.0 KIT MYOD1
24 fibromatosis 10.0 DES KIT
25 intraneural perineurioma 10.0 CD34 KRT18
26 histiocytoma 10.0 KIT MYOD1
27 ovarian fibrothecoma 10.0 DES KIT
28 pulmonary vein stenosis 10.0 DES KIT
29 gallbladder leiomyoma 10.0 CD34 KIT
30 cystic nephroma 10.0 DES KIT
31 lung leiomyosarcoma 10.0 CD34 KIT
32 liver leiomyoma 10.0 CD34 KIT
33 deep leiomyoma 10.0 CD34 KIT
34 perivascular epithelioid cell tumor 10.0 DES KIT
35 extracutaneous mastocytoma 10.0 CD34 KIT
36 small intestine leiomyosarcoma 10.0 CD34 KIT
37 small intestinal sarcoma 10.0 CD34 KIT
38 inflammatory leiomyosarcoma 10.0 DES MYOD1 MYOG
39 adenosarcoma 10.0 DES KIT
40 prostate leiomyosarcoma 10.0 CD34 KIT
41 medullomyoblastoma 10.0 DES MYOD1 MYOG
42 plexiform schwannoma 10.0 CD34 KIT
43 embryonal rhabdomyosarcoma 10.0 DES MYOD1 MYOG
44 conventional fibrosarcoma 10.0 CD34 KIT
45 sarcoma 10.0
46 smooth muscle tumor 10.0 DES KIT
47 peritoneal benign neoplasm 10.0 CD34 KIT
48 rhabdomyosarcoma 2 10.0 DES MYOD1 MYOG
49 diffuse peritoneal leiomyomatosis 9.9 CD34 KIT
50 breast angiosarcoma 9.9 CD34 KIT

Graphical network of the top 20 diseases related to Gallbladder Sarcoma:



Diseases related to Gallbladder Sarcoma
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Symptoms & Phenotypes for Gallbladder Sarcoma

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MGI Mouse Phenotypes related to Gallbladder Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 DES KIT MYOD1 MYOG
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Drugs & Therapeutics for Gallbladder Sarcoma

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Search Clinical Trials , NIH Clinical Center for Gallbladder Sarcoma

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Genetic Tests for Gallbladder Sarcoma

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Anatomical Context for Gallbladder Sarcoma

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MalaCards organs/tissues related to Gallbladder Sarcoma:

41
Lung, Liver, Bone, Prostate, Smooth Muscle, Skeletal Muscle, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Sarcoma:

19
The Gallbladder
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Publications for Gallbladder Sarcoma

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Articles related to Gallbladder Sarcoma:

# Title Authors Year
1
Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. ( 19194282 )
2009
2
Gallbladder sarcoma: a clinicopathological study of seven cases from the UK and Austria with emphasis on morphological subtypes. ( 18618258 )
2009
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Variations for Gallbladder Sarcoma

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Expression for Gallbladder Sarcoma

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Search GEO for disease gene expression data for Gallbladder Sarcoma.
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Pathways for Gallbladder Sarcoma

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Pathways related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 66
Show member pathways
 12.92 KIT KRT18 MYOD1 MYOG
2
Hematopoietic cell lineage 37
11.35 CD34 KIT
3
Innate Lymphoid Cell Differentiation Pathways 65
11.22 CD34 KIT
4
Dendritic Cells Developmental Lineage Pathway 65
11.13 CD34 KIT
5
Myogenesis 66
Show member pathways
 10.92 MYOD1 MYOG
6
C-MYB transcription factor network 1
10.69 CD34 KIT MYOD1
7
B Cell Development Pathways 65
10.68 CD34 KIT
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GO Terms for Gallbladder Sarcoma

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Cellular components related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 CD34 KRT18

Biological processes related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 9.52 MYOD1 MYOG
2 hemopoiesis GO:0030097 9.51 CD34 KIT
3 skeletal muscle tissue development GO:0007519 9.49 MYOD1 MYOG
4 skeletal muscle cell differentiation GO:0035914 9.48 MYOD1 MYOG
5 cellular response to estradiol stimulus GO:0071392 9.46 MYOD1 MYOG
6 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOD1 MYOG
7 skeletal muscle fiber development GO:0048741 9.4 MYOD1 MYOG
8 positive regulation of myoblast differentiation GO:0045663 9.37 MYOD1 MYOG
9 myoblast differentiation GO:0045445 9.32 MYOD1 MYOG
10 positive regulation of myoblast fusion GO:1901741 9.26 MYOD1 MYOG
11 myotube differentiation GO:0014902 9.16 MYOD1 MYOG
12 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
13 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.16 MYOD1 MYOG
2 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
3 E-box binding GO:0070888 8.62 MYOD1 MYOG
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Sources for Gallbladder Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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