MCID: GLL021
MIFTS: 26

Gallbladder Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Sarcoma

MalaCards integrated aliases for Gallbladder Sarcoma:

Name: Gallbladder Sarcoma 12 15 73
Malignant Mesenchymal Tumor of Gallbladder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4058
NCIt 50 C5736
UMLS 73 C1333757

Summaries for Gallbladder Sarcoma

Disease Ontology : 12 A sarcoma that is located in the gallbladder.

MalaCards based summary : Gallbladder Sarcoma, also known as malignant mesenchymal tumor of gallbladder, is related to botryoid rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Gallbladder Sarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Developmental Biology and Hematopoietic cell lineage. Affiliated tissues include the gallbladder, and related phenotype is muscle.

Related Diseases for Gallbladder Sarcoma

Diseases related to Gallbladder Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 botryoid rhabdomyosarcoma 30.2 DES MYOD1
2 rhabdomyosarcoma 29.2 DES MYOD1 MYOG
3 gallbladder rhabdomyosarcoma 11.0
4 gallbladder angiosarcoma 11.0
5 gallbladder leiomyosarcoma 11.0
6 cervical polyp 10.5 DES MYOD1
7 mesenchymoma 10.5 DES MYOD1
8 spindle cell rhabdomyosarcoma 10.4 DES MYOD1
9 horner's syndrome 10.4 DES MYOD1
10 malignant fibrous histiocytoma of bone 10.4 DES MYOD1
11 undifferentiated embryonal sarcoma of the liver 10.4 MYOD1 MYOG
12 rhabdoid cancer 10.4 DES MYOD1
13 conventional leiomyosarcoma 10.4 MYOD1 MYOG
14 malignant fibroxanthoma 10.3 DES MYOD1
15 adult fibrosarcoma 10.3 MYOD1 MYOG
16 ischemic fasciitis 10.3 CD34 DES
17 pseudosarcomatous fibromatosis 10.2 DES MYOG
18 congenital epulis 10.2 CD34 DES
19 extraosseous ewing's sarcoma 10.2 MYOD1 MYOG
20 glomangioma 10.2 CD34 DES
21 alveolar soft part sarcoma 10.2 DES MYOD1
22 skeletal muscle cancer 10.1 MYOD1 MYOG
23 prostate embryonal rhabdomyosarcoma 10.0 KIT MYOD1
24 intraneural perineurioma 10.0 CD34 KRT18
25 prostate rhabdomyosarcoma 10.0 KIT MYOD1
26 ovarian fibrothecoma 10.0 DES KIT
27 pulmonary vein stenosis 9.9 DES KIT
28 cystic nephroma 9.9 DES KIT
29 gallbladder leiomyoma 9.9 CD34 KIT
30 lung leiomyosarcoma 9.9 CD34 KIT
31 liver leiomyoma 9.9 CD34 KIT
32 deep leiomyoma 9.9 CD34 KIT
33 extracutaneous mastocytoma 9.9 CD34 KIT
34 small intestine leiomyosarcoma 9.9 CD34 KIT
35 small intestinal sarcoma 9.9 CD34 KIT
36 perivascular epithelioid cell tumor 9.9 DES KIT
37 prostate leiomyosarcoma 9.9 CD34 KIT
38 adenosarcoma 9.9 DES KIT
39 breast rhabdomyosarcoma 9.9 DES MYOD1 MYOG
40 diffuse cutaneous mastocytosis 9.9 CD34 KIT
41 inflammatory leiomyosarcoma 9.9 DES MYOD1 MYOG
42 sarcomatoid squamous cell skin carcinoma 9.9 CD34 KIT
43 gastric leiomyosarcoma 9.9 CD34 KIT
44 medullomyoblastoma 9.9 DES MYOD1 MYOG
45 embryonal rhabdomyosarcoma 9.9 DES MYOD1 MYOG
46 breast angiosarcoma 9.9 CD34 KIT
47 smooth muscle tumor 9.9 DES KIT
48 rhabdomyosarcoma 2 9.9 DES MYOD1 MYOG
49 plexiform schwannoma 9.9 CD34 KIT
50 conventional fibrosarcoma 9.9 CD34 KIT

Graphical network of the top 20 diseases related to Gallbladder Sarcoma:



Diseases related to Gallbladder Sarcoma

Symptoms & Phenotypes for Gallbladder Sarcoma

MGI Mouse Phenotypes related to Gallbladder Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 DES KIT MYOD1 MYOG

Drugs & Therapeutics for Gallbladder Sarcoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Sarcoma

Genetic Tests for Gallbladder Sarcoma

Anatomical Context for Gallbladder Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Sarcoma:

19
The Gallbladder

Publications for Gallbladder Sarcoma

Articles related to Gallbladder Sarcoma:

# Title Authors Year
1
Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. ( 19194282 )
2009
2
Gallbladder sarcoma: a clinicopathological study of seven cases from the UK and Austria with emphasis on morphological subtypes. ( 18618258 )
2009

Variations for Gallbladder Sarcoma

Expression for Gallbladder Sarcoma

Search GEO for disease gene expression data for Gallbladder Sarcoma.

Pathways for Gallbladder Sarcoma

Pathways related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.92 KIT KRT18 MYOD1 MYOG
2 11.35 CD34 KIT
3 11.22 CD34 KIT
4 11.13 CD34 KIT
5
Show member pathways
10.92 MYOD1 MYOG
6 10.69 CD34 KIT MYOD1
7 10.68 CD34 KIT

GO Terms for Gallbladder Sarcoma

Cellular components related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 CD34 KRT18

Biological processes related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 hemopoiesis GO:0030097 9.51 CD34 KIT
2 skeletal muscle tissue development GO:0007519 9.49 MYOD1 MYOG
3 skeletal muscle cell differentiation GO:0035914 9.48 MYOD1 MYOG
4 cellular response to estradiol stimulus GO:0071392 9.46 MYOD1 MYOG
5 skeletal muscle fiber development GO:0048741 9.43 MYOD1 MYOG
6 positive regulation of muscle cell differentiation GO:0051149 9.4 MYOD1 MYOG
7 positive regulation of myoblast differentiation GO:0045663 9.37 MYOD1 MYOG
8 myoblast differentiation GO:0045445 9.32 MYOD1 MYOG
9 positive regulation of myoblast fusion GO:1901741 9.26 MYOD1 MYOG
10 myotube differentiation GO:0014902 9.16 MYOD1 MYOG
11 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
12 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Gallbladder Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.26 MYOD1 MYOG
2 core promoter binding GO:0001047 9.16 MYOD1 MYOG
3 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
4 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Gallbladder Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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