MCID: GLL015
MIFTS: 34

Gallbladder Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Gallbladder Squamous Cell Carcinoma

MalaCards integrated aliases for Gallbladder Squamous Cell Carcinoma:

Name: Gallbladder Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of the Gallbladder 12 73
Epidermoid Gallbladder Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5535
NCIt 50 C9170
UMLS 73 C0279658

Summaries for Gallbladder Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the gallbladder.

MalaCards based summary : Gallbladder Squamous Cell Carcinoma, also known as squamous cell carcinoma of the gallbladder, is related to squamous cell carcinoma and epididymis cancer, and has symptoms including abdominal pain An important gene associated with Gallbladder Squamous Cell Carcinoma is CD86 (CD86 Molecule), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Alzheimers Disease Pathway. The drugs Capecitabine and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and skin.

Related Diseases for Gallbladder Squamous Cell Carcinoma

Diseases related to Gallbladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.3
2 epididymis cancer 10.1 CD86 CEACAM5
3 epididymis adenocarcinoma 10.1 CD86 CEACAM5
4 lymphohistiocytoid mesothelioma 10.1 CD86 CEACAM5
5 liver lymphoma 10.0 CEACAM5 SMUG1
6 splenic tuberculosis 10.0 CEACAM5 SMUG1
7 malignant acrospiroma 10.0 CEACAM5 SMUG1
8 malignant spiradenoma 10.0 CEACAM5 SMUG1
9 tolosa-hunt syndrome 10.0 CEACAM5 SMUG1
10 eccrine adenocarcinoma 10.0 CEACAM5 SMUG1
11 pericardial tuberculosis 10.0 CEACAM5 SMUG1
12 prostate squamous cell carcinoma 10.0 CEACAM5 SMUG1
13 tuberculous peritonitis 10.0 CEACAM5 SMUG1
14 xanthogranulomatous cholecystitis 10.0 CEACAM5 SMUG1
15 alzheimer disease 2 10.0 APP SMUG1
16 tracheal cancer 10.0 CEACAM5 SMUG1
17 pleural disease 10.0 CEACAM5 SMUG1
18 gallbladder disease 1 10.0
19 cholecystitis 10.0
20 adenocarcinoma in situ 10.0
21 adenoid squamous cell carcinoma 10.0
22 breast squamous cell carcinoma 10.0 CD86 ERBB2
23 adenocarcinoma 10.0
24 intracystic papillary adenoma 9.9 CEACAM5 ERBB2
25 rectal neoplasm 9.9 CEACAM5 SMUG1
26 mixed cell type cancer 9.9 CEACAM5 ERBB2
27 dementia, lewy body 9.9 APP SMUG1
28 papillary adenocarcinoma 9.9 CEACAM5 ERBB2
29 ovary adenocarcinoma 9.9 CEACAM5 ERBB2
30 intestinal disease 9.9 CEACAM5 SMUG1
31 ovarian cancer 1 9.9 CEACAM5 ERBB2
32 malignant ovarian surface epithelial-stromal neoplasm 9.9 CEACAM5 ERBB2
33 ovary epithelial cancer 9.9 CEACAM5 ERBB2
34 cystadenocarcinoma 9.9 CEACAM5 ERBB2
35 respiratory system disease 9.9 CEACAM5 SMUG1
36 stomach disease 9.9 CEACAM5 ERBB2
37 thyroid cancer, nonmedullary, 2 9.9 CEACAM5 SMUG1
38 mucoepidermoid carcinoma 9.9 CEACAM5 ERBB2
39 uterine anomalies 9.9 ERBB2 SMUG1
40 female reproductive system disease 9.8 ERBB2 SMUG1
41 descending colon cancer 9.8 APP CEACAM5 SMUG1
42 reproductive system disease 9.8 ERBB2 SMUG1
43 nervous system disease 9.8 APP SMUG1
44 vulval paget's disease 9.8 CD86 CEACAM5 ERBB2
45 vulva adenocarcinoma 9.8 CD86 CEACAM5 ERBB2
46 esophageal disease 9.7 CEACAM5 ERBB2 SMUG1
47 respiratory system cancer 9.7 CEACAM5 ERBB2 SMUG1
48 gastrointestinal system cancer 9.7 CEACAM5 ERBB2 SMUG1
49 endocrine gland cancer 9.7 CEACAM5 ERBB2 SMUG1
50 gastrointestinal system disease 9.7 CEACAM5 ERBB2 SMUG1

Graphical network of the top 20 diseases related to Gallbladder Squamous Cell Carcinoma:



Diseases related to Gallbladder Squamous Cell Carcinoma

Symptoms & Phenotypes for Gallbladder Squamous Cell Carcinoma

UMLS symptoms related to Gallbladder Squamous Cell Carcinoma:


abdominal pain

Drugs & Therapeutics for Gallbladder Squamous Cell Carcinoma

Drugs for Gallbladder Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3,Phase 2 154361-50-9 60953
2 Liver Extracts Phase 3
3 Antimetabolites, Antineoplastic Phase 3,Phase 2
4 Antimetabolites Phase 3,Phase 2
5
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
6
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
7
Gemcitabine Approved Phase 2 95058-81-4 60750
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
9
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
10 Micronutrients Phase 2
11 Vitamins Phase 2
12 Vitamin B9 Phase 2
13 Trace Elements Phase 2
14 Vitamin B3 Phase 2
15 Protein Kinase Inhibitors Phase 2
16 Vitamin B Complex Phase 2
17 Nicotinic Acids Phase 2
18 Folate Phase 2
19 Antiviral Agents Phase 2
20 Immunosuppressive Agents Phase 2
21 Anti-Infective Agents Phase 2
22 Immunologic Factors Phase 2
23
Dimenhydrinate Approved 523-87-5 441281
24
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
25
Ethanol Approved 64-17-5 702
26 Immunoglobulins
27 Antibodies
28 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
2 S0514 Sorafenib in Treating Patients With Unresectable or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00238212 Phase 2 sorafenib tosylate
3 S0202 Gemcitabine and Capecitabine for Unresectable Locally Advanced Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00033540 Phase 2 capecitabine;gemcitabine hydrochloride
4 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Gallbladder Squamous Cell Carcinoma

Genetic Tests for Gallbladder Squamous Cell Carcinoma

Anatomical Context for Gallbladder Squamous Cell Carcinoma

MalaCards organs/tissues related to Gallbladder Squamous Cell Carcinoma:

41
Liver, Lymph Node, Skin, Colon, Ovary, Pancreas, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Squamous Cell Carcinoma:

19
The Gallbladder

Publications for Gallbladder Squamous Cell Carcinoma

Articles related to Gallbladder Squamous Cell Carcinoma:

(show all 28)
# Title Authors Year
1
Synchronous gallbladder squamous cell carcinoma and adenocarcinoma, both as primary tumors in one patient. ( 29549846 )
2018
2
Primary squamous cell carcinoma of the gallbladder: Report of a rare neoplasm from the Eastern Province of Saudi Arabia. ( 30176555 )
2018
3
A case of primary squamous cell carcinoma of the gallbladder with local invasion of the liver and peritoneum, and metastasis to the omentum. ( 29487667 )
2018
4
Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass. ( 29515940 )
2018
5
Hepatobiliary and Pancreatic: A case of pure squamous cell carcinoma of the gallbladder. ( 29659084 )
2018
6
Acantholytic squamous cell carcinoma of the gallbladder mimicking adenocarcinoma. ( 29671927 )
2018
7
Primary Pure Squamous Cell Carcinoma of the Gallbladder Locally Invading the Liver, Duodenum, and Stomach: A Case Report and Literature Review. ( 28251014 )
2017
8
Pearls before bile: Primary squamous cell carcinoma of the gallbladder diagnosed on-site by endoscopic ultrasound-guided fine-needle aspiration. ( 26473633 )
2016
9
Squamous cell carcinoma of the gallbladder. ( 28138644 )
2016
10
Overlap of Acute Cholecystitis with Gallstones and Squamous Cell Carcinoma of the Gallbladder in an Elderly Patient. ( 26356191 )
2015
11
Locally Advanced, Unresectable Squamous Cell Carcinoma of the Gallbladder. ( 26236536 )
2015
12
Port site metastases in squamous cell carcinoma of the gallbladder. ( 24761709 )
2014
13
A case of pure endophytic squamous cell carcinoma of the gallbladder: a rare entity with aggressive behaviour. ( 22627641 )
2012
14
Preoperative diagnosis of squamous cell carcinoma of the gallbladder by ultrasound-guided aspiration cytology: clinical and cytological findings of nine cases. ( 22791136 )
2012
15
Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder. ( 21337551 )
2011
16
Case report: Primary pure squamous cell carcinoma of the gallbladder. ( 21497148 )
2011
17
Radical surgery for advanced pure squamous cell carcinoma of the gallbladder: report of a case. ( 22234081 )
2011
18
Gallbladder squamous cell carcinoma in the setting of low-dose methotrexate use. ( 19895533 )
2009
19
Adenosquamous/squamous cell carcinoma of the gallbladder. ( 17262729 )
2007
20
Radical surgery for advanced squamous cell carcinoma of the gallbladder: a report of three cases, including a 10-year survivor. ( 17523272 )
2007
21
Squamous cell carcinoma of the gallbladder. ( 11175625 )
2001
22
Minute squamous cell carcinoma of the gallbladder: a case report. ( 10770570 )
2000
23
Fine needle aspiration cytodiagnosis of primary squamous cell carcinoma of the gallbladder. Report of two cases. ( 10834014 )
2000
24
Hepatopancreatoduodenectomy for squamous cell carcinoma of the gallbladder. ( 11020855 )
2000
25
Squamous cell carcinoma of the gallbladder presenting with a biliary-colic fistula. ( 7589614 )
1995
26
Squamous cell carcinoma of the gallbladder. ( 8326694 )
1993
27
HST1 and INT2 gene coamplification in a squamous cell carcinoma of the gallbladder. ( 2921814 )
1989
28
Squamous cell carcinoma of the gallbladder associated with squamous metaplasia and adenocarcinoma in situ of the mucosal columnar epithelium. ( 3825536 )
1986

Variations for Gallbladder Squamous Cell Carcinoma

Expression for Gallbladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gallbladder Squamous Cell Carcinoma.

Pathways for Gallbladder Squamous Cell Carcinoma

Pathways related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 CD86 CEACAM5
2 10.28 APP ERBB2

GO Terms for Gallbladder Squamous Cell Carcinoma

Cellular components related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 APP CD86 CEACAM5

Biological processes related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 8.62 CD86 ERBB2

Molecular functions related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.62 CD86 ERBB2

Sources for Gallbladder Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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