MCID: GLL015
MIFTS: 31

Gallbladder Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Gallbladder Squamous Cell Carcinoma

MalaCards integrated aliases for Gallbladder Squamous Cell Carcinoma:

Name: Gallbladder Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of the Gallbladder 12 73
Epidermoid Gallbladder Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5535
NCIt 50 C9170
UMLS 73 C0279658

Summaries for Gallbladder Squamous Cell Carcinoma

MalaCards based summary : Gallbladder Squamous Cell Carcinoma, also known as squamous cell carcinoma of the gallbladder, is related to mucoepidermoid esophageal carcinoma and intracranial chondrosarcoma, and has symptoms including abdominal pain An important gene associated with Gallbladder Squamous Cell Carcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Downstream signaling events of B Cell Receptor (BCR) and DNA Damage Response (only ATM dependent). The drugs Capecitabine and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node.

Related Diseases for Gallbladder Squamous Cell Carcinoma

Diseases related to Gallbladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 mucoepidermoid esophageal carcinoma 10.4 CEACAM5 TP53
2 intracranial chondrosarcoma 10.4 CEACAM5 TP53
3 atypical follicular adenoma 10.4 CEACAM5 TP53
4 bartholin's gland benign neoplasm 10.3 CD86 TP53
5 biliary papillomatosis 10.3 CEACAM5 TP53
6 epididymis cancer 10.3 CD86 CEACAM5
7 epididymis adenocarcinoma 10.3 CD86 CEACAM5
8 lymphohistiocytoid mesothelioma 10.3 CD86 CEACAM5
9 bile duct adenocarcinoma 10.3 CEACAM5 TP53
10 gastrointestinal system benign neoplasm 10.3 CEACAM5 TP53
11 intestinal benign neoplasm 10.3 CEACAM5 TP53
12 bartholin's duct cyst 10.2 SMUG1 TP53
13 cellular ependymoma 10.2 SMUG1 TP53
14 scrotal carcinoma 10.2 SMUG1 TP53
15 mature teratoma 10.2 SMUG1 TP53
16 organ system benign neoplasm 10.2 CEACAM5 TP53
17 integumentary system cancer 10.2 CEACAM5 TP53
18 oropharynx cancer 10.2 SMUG1 TP53
19 cell type benign neoplasm 10.2 CEACAM5 TP53
20 liver lymphoma 10.2 CEACAM5 SMUG1
21 splenic tuberculosis 10.2 CEACAM5 SMUG1
22 tolosa-hunt syndrome 10.2 CEACAM5 SMUG1
23 gastric signet ring cell adenocarcinoma 10.2 CEACAM5 SMUG1
24 eccrine adenocarcinoma 10.2 CEACAM5 SMUG1
25 femoral neuropathy 10.1 CEACAM5 SMUG1
26 pericardial tuberculosis 10.1 CEACAM5 SMUG1
27 colorectal adenocarcinoma 10.1 CEACAM5 TP53
28 pharynx cancer 10.1 SMUG1 TP53
29 descending colon cancer 10.1 CEACAM5 SMUG1
30 connective tissue cancer 10.1 SMUG1 TP53
31 tuberculous peritonitis 10.1 CEACAM5 SMUG1
32 thymus cancer 10.0 SMUG1 TP53
33 gastric papillary adenocarcinoma 10.0 ERBB2 TP53
34 uterine corpus serous adenocarcinoma 10.0 ERBB2 TP53
35 non-proliferative fibrocystic change of the breast 10.0 ERBB2 TP53
36 pleomorphic adenoma carcinoma 10.0 ERBB2 TP53
37 fallopian tube adenocarcinoma 10.0 ERBB2 TP53
38 uterine body mixed cancer 10.0 ERBB2 TP53
39 squamous cell carcinoma 10.0
40 glioma susceptibility 1 10.0 ERBB2 TP53
41 oral leukoplakia 10.0 ERBB2 TP53
42 microglandular adenosis 10.0 ERBB2 TP53
43 uterine corpus cancer 10.0 ERBB2 TP53
44 breast benign neoplasm 10.0 ERBB2 TP53
45 thoracic benign neoplasm 10.0 ERBB2 TP53
46 esophagus adenocarcinoma 10.0 ERBB2 TP53
47 mixed cell type cancer 9.9 ERBB2 TP53
48 breast mucoepidermoid carcinoma 9.9 CEACAM5 ERBB2
49 granulosa cell tumor of the ovary 9.9 ERBB2 TP53
50 hidradenocarcinoma 9.9 ERBB2 TP53

Graphical network of the top 20 diseases related to Gallbladder Squamous Cell Carcinoma:



Diseases related to Gallbladder Squamous Cell Carcinoma

Symptoms & Phenotypes for Gallbladder Squamous Cell Carcinoma

UMLS symptoms related to Gallbladder Squamous Cell Carcinoma:


abdominal pain

Drugs & Therapeutics for Gallbladder Squamous Cell Carcinoma

Drugs for Gallbladder Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3,Phase 2 154361-50-9 60953
2 Liver Extracts Phase 3
3 Antimetabolites Phase 3,Phase 2
4 Antimetabolites, Antineoplastic Phase 3,Phase 2
5
Gemcitabine Approved Phase 2 95058-81-4 60750
6
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
7
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
8
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
10 Micronutrients Phase 2
11 Nicotinic Acids Phase 2
12 Trace Elements Phase 2
13 Vitamin B Complex Phase 2
14 Vitamins Phase 2
15 Immunosuppressive Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Protein Kinase Inhibitors Phase 2
18 Antiviral Agents Phase 2
19 Folate Nutraceutical Phase 2
20 Vitamin B3 Nutraceutical Phase 2
21 Vitamin B9 Nutraceutical Phase 2
22
Dimenhydrinate Approved 523-87-5 441281
23
Ethanol Approved 64-17-5 702
24
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
25 Pharmaceutical Solutions
26 Antibodies
27 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
2 S0514 Sorafenib in Treating Patients With Unresectable or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00238212 Phase 2 sorafenib tosylate
3 S0202 Gemcitabine and Capecitabine for Unresectable Locally Advanced Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00033540 Phase 2 capecitabine;gemcitabine hydrochloride
4 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Gallbladder Squamous Cell Carcinoma

Genetic Tests for Gallbladder Squamous Cell Carcinoma

Anatomical Context for Gallbladder Squamous Cell Carcinoma

MalaCards organs/tissues related to Gallbladder Squamous Cell Carcinoma:

41
Liver, Lymph Node

Publications for Gallbladder Squamous Cell Carcinoma

Articles related to Gallbladder Squamous Cell Carcinoma:

# Title Authors Year
1
Synchronous gallbladder squamous cell carcinoma and adenocarcinoma, both as primary tumors in one patient. ( 29549846 )
2018
2
Gallbladder squamous cell carcinoma in the setting of low-dose methotrexate use. ( 19895533 )
2009
3
Squamous cell carcinoma of the gallbladder associated with squamous metaplasia and adenocarcinoma in situ of the mucosal columnar epithelium. ( 3825536 )
1986

Variations for Gallbladder Squamous Cell Carcinoma

Expression for Gallbladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gallbladder Squamous Cell Carcinoma.

Pathways for Gallbladder Squamous Cell Carcinoma

Pathways related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.44 CD86 ERBB2 TP53
2 11.43 ERBB2 TP53
3 11.18 ERBB2 TP53
4 11.12 ERBB2 TP53
5 10.98 ERBB2 TP53
6 10.77 ERBB2 TP53

GO Terms for Gallbladder Squamous Cell Carcinoma

Biological processes related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.16 CD86 ERBB2
2 negative regulation of apoptotic process GO:0043066 9.13 CEACAM5 ERBB2 TP53
3 base-excision repair GO:0006284 8.62 SMUG1 TP53

Molecular functions related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 8.96 ERBB2 TP53
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.62 CD86 ERBB2

Sources for Gallbladder Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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