MCID: GLL015
MIFTS: 31

Gallbladder Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Gallbladder Squamous Cell Carcinoma

MalaCards integrated aliases for Gallbladder Squamous Cell Carcinoma:

Name: Gallbladder Squamous Cell Carcinoma 12 15 17
Squamous Cell Carcinoma of the Gallbladder 12 70
Epidermoid Gallbladder Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5535
NCIt 50 C9170
UMLS 70 C0279658

Summaries for Gallbladder Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the gallbladder.

MalaCards based summary : Gallbladder Squamous Cell Carcinoma, also known as squamous cell carcinoma of the gallbladder, is related to adenosquamous carcinoma and keratinizing squamous cell carcinoma, and has symptoms including abdominal pain An important gene associated with Gallbladder Squamous Cell Carcinoma is CD109 (CD109 Molecule), and among its related pathways/superpathways are Post-translational modification- synthesis of GPI-anchored proteins and MECP2 and Associated Rett Syndrome. The drugs Capecitabine and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include gallbladder, liver and lymph node.

Related Diseases for Gallbladder Squamous Cell Carcinoma

Diseases related to Gallbladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 30.2 KRT5 CEACAM5
2 keratinizing squamous cell carcinoma 30.0 KRT5 CEACAM5
3 gallbladder disease 1 10.4
4 gallbladder adenocarcinoma 10.4
5 squamous cell carcinoma 10.3
6 adenocarcinoma in situ 10.3
7 rare tumor 10.3
8 alcohol dependence 10.1
9 cholelithiasis 10.0
10 cholecystitis 10.0
11 adenocarcinoma 10.0
12 gallbladder cancer 10.0
13 peritonitis 10.0
14 lacrimoauriculodentodigital syndrome 9.9 FGF4 FGF3
15 apert syndrome 9.9 FGF4 FGF3
16 crouzon syndrome 9.8 FGF4 FGF3
17 mucoepidermoid esophageal carcinoma 9.8 KRT5 CEACAM5
18 ureter adenocarcinoma 9.8 KRT5 CEACAM5
19 breast cystic hypersecretory carcinoma 9.8 KRT5 CEACAM5
20 malignant acrospiroma 9.8 KRT5 CEACAM5
21 thymus adenocarcinoma 9.8 KRT5 CEACAM5
22 vulva basal cell carcinoma 9.8 KRT5 CEACAM5
23 cutaneous mucoepidermoid carcinoma 9.8 KRT5 CEACAM5
24 mucoepidermoid carcinoma 9.8 KRT5 CEACAM5
25 external ear carcinoma 9.8 KRT5 CEACAM5
26 eccrine adenocarcinoma 9.8 KRT5 CEACAM5
27 vulvar apocrine adenocarcinoma 9.8 KRT5 CEACAM5
28 colon leiomyosarcoma 9.8 KRT5 CEACAM5
29 papillary squamous carcinoma 9.8 KRT5 CEACAM5
30 malignant syringoma 9.8 KRT5 CEACAM5
31 bile duct mucoepidermoid carcinoma 9.8 KRT5 CEACAM5
32 pericardium cancer 9.8 KRT5 CEACAM5
33 clear cell hidradenoma 9.8 KRT5 CEACAM5
34 hidradenoma 9.8 KRT5 CEACAM5
35 eccrine sweat gland cancer 9.8 KRT5 CEACAM5
36 sweat gland cancer 9.8 KRT5 CEACAM5
37 eccrine papillary adenocarcinoma 9.8 KRT5 CEACAM5
38 eccrine acrospiroma 9.8 KRT5 CEACAM5
39 eccrine sweat gland neoplasm 9.8 KRT5 CEACAM5
40 esophageal adenosquamous carcinoma 9.8 KRT5 CEACAM5
41 cutaneous adenocystic carcinoma 9.8 KRT5 CEACAM5
42 lung leiomyosarcoma 9.8 KRT5 CEACAM5
43 clear cell basal cell carcinoma 9.8 KRT5 CEACAM5
44 intracystic papillary adenoma 9.8 KRT5 CEACAM5
45 papillary adenoma 9.8 KRT5 CEACAM5
46 nasal cavity olfactory neuroblastoma 9.8 KRT5 CEACAM5
47 urethral benign neoplasm 9.8 KRT5 CEACAM5
48 apocrine sweat gland neoplasm 9.8 KRT5 CEACAM5
49 cystic basal cell carcinoma 9.8 KRT5 CEACAM5
50 malignant spiradenoma 9.8 KRT5 CEACAM5

Graphical network of the top 20 diseases related to Gallbladder Squamous Cell Carcinoma:



Diseases related to Gallbladder Squamous Cell Carcinoma

Symptoms & Phenotypes for Gallbladder Squamous Cell Carcinoma

UMLS symptoms related to Gallbladder Squamous Cell Carcinoma:


abdominal pain

Drugs & Therapeutics for Gallbladder Squamous Cell Carcinoma

Drugs for Gallbladder Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
2 Antimetabolites Phase 3
3 Liver Extracts Phase 3
4
Gemcitabine Approved Phase 2 95058-81-4 60750
5 Anti-Infective Agents Phase 2
6 Immunosuppressive Agents Phase 2
7 Antiviral Agents Phase 2
8 Immunologic Factors Phase 2
9
Ethanol Approved 64-17-5 702
10
Dimenhydrinate Approved 523-87-5 441281
11
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
12 Pharmaceutical Solutions
13 Antibodies
14 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Clinical Trial Evaluating Adjuvant Chemotherapy With Capecitabine Compared to Expectant Treatment Alone (Observation) Following Surgery for Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
2 A Phase II Trial of Gemcitabine (NSC-613327) and Capecitabine (NSC-712807) in Patients With Unresectable or Metastatic Gallbladder or Cholangiocarcinoma Completed NCT00033540 Phase 2 capecitabine;gemcitabine hydrochloride
3 Study of The Examination of Sentinel Lymph Nodes for OX-40 Expression in Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Gallbladder Squamous Cell Carcinoma

Genetic Tests for Gallbladder Squamous Cell Carcinoma

Anatomical Context for Gallbladder Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Squamous Cell Carcinoma:

19
Gallbladder

MalaCards organs/tissues related to Gallbladder Squamous Cell Carcinoma:

40
Liver, Lymph Node, Colon

Publications for Gallbladder Squamous Cell Carcinoma

Articles related to Gallbladder Squamous Cell Carcinoma:

(show top 50) (show all 59)
# Title Authors PMID Year
1
Characteristics and survival prognosis of patients with pure squamous cell carcinoma of the gallbladder. 61
33236449 2021
2
A Case of Effective Endoscopic Closure of Cholecysto-duodenal and Transverse Colon Fistulas due to Squamous Cell Carcinoma of the Gallbladder using Polyglycolic Acid Sheets and a Covered Metal Stent. 61
33390496 2020
3
Adeno-squamous and squamous cell carcinoma of the gallbladder: The importance of histology in surgical management. 61
32646581 2020
4
Advanced primary squamous cell carcinoma of gallbladder and potential predictive biomarkers for prognosis. 61
32790516 2020
5
Gallbladder squamous cell carcinoma: An analysis of 1084 cases from the National Cancer Database. 61
32510655 2020
6
Surgical resection of advanced gallbladder squamous cell carcinoma accompanied by infiltration of the surrounding organs and general peritonitis. 61
32731175 2020
7
Pure squamous cell carcinoma of the gallbladder locally invading the liver and abdominal cavity: A case report and review of the literature. 61
31832423 2019
8
Giant squamous cell carcinoma of the gallbladder: A case report. 61
31616693 2019
9
Hepatobiliary and Pancreatic: A case of pure squamous cell carcinoma of the gallbladder. 61
29659084 2018
10
Acantholytic squamous cell carcinoma of the gallbladder mimicking adenocarcinoma. 61
29671927 2018
11
A case of primary squamous cell carcinoma of the gallbladder with local invasion of the liver and peritoneum, and metastasis to the omentum. 61
29487667 2018
12
Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass. 61
29515940 2018
13
Synchronous gallbladder squamous cell carcinoma and adenocarcinoma, both as primary tumors in one patient. 61
29549846 2018
14
Primary squamous cell carcinoma of the gallbladder: Report of a rare neoplasm from the Eastern Province of Saudi Arabia. 61
30176555 2018
15
Clinicopathological features and survival of gallbladder squamous cell carcinoma: analysis of 121 cases. 61
31949696 2018
16
Primary Pure Squamous Cell Carcinoma of the Gallbladder Locally Invading the Liver, Duodenum, and Stomach: A Case Report and Literature Review. 61
28251014 2017
17
Squamous cell carcinoma of the gallbladder. 61
28138644 2016
18
Pearls before bile: Primary squamous cell carcinoma of the gallbladder diagnosed on-site by endoscopic ultrasound-guided fine-needle aspiration. 61
26473633 2016
19
The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. 61
25063238 2015
20
Overlap of Acute Cholecystitis with Gallstones and Squamous Cell Carcinoma of the Gallbladder in an Elderly Patient. 61
26356191 2015
21
Locally Advanced, Unresectable Squamous Cell Carcinoma of the Gallbladder. 61
26236536 2015
22
[Squamous cell carcinoma of the gallbladder: report of a case]. 61
27047622 2015
23
Port site metastases in squamous cell carcinoma of the gallbladder. 61
24761709 2014
24
Cytohistopathological correlation of a case of squamous cell carcinoma of gallbladder with lymph node metastasis. 61
24101354 2014
25
[A long survival after the treatment of a squamous cell carcinoma of the gallbladder]. 61
23352563 2013
26
[Primary pure squamous cell carcinoma of the gallbladder revealed by an acute angiocholitis]. 61
22386111 2013
27
Preoperative diagnosis of squamous cell carcinoma of the gallbladder by ultrasound-guided aspiration cytology: clinical and cytological findings of nine cases. 61
22791136 2012
28
Primary pure squamous cell carcinoma of gallbladder presenting as acute cholecystitis. 61
23390334 2012
29
[Primary keratinizing squamous cell carcinoma of the gallbladder: report of a case]. 61
23324241 2012
30
Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy. 61
22740944 2012
31
A case of pure endophytic squamous cell carcinoma of the gallbladder: a rare entity with aggressive behaviour. 61
22627641 2012
32
Radical surgery for advanced pure squamous cell carcinoma of the gallbladder: report of a case. 61
22234081 2011
33
[Acute squamous cell carcinoma of the gallbladder: a rare cause of acute cholecystitis]. 61
21713720 2011
34
Case report: Primary pure squamous cell carcinoma of the gallbladder. 61
21497148 2011
35
Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder. 61
21337551 2011
36
Conformal radiotherapy for squamous cell carcinoma of gallbladder: a case report. 61
20339506 2010
37
Gallbladder squamous cell carcinoma in the setting of low-dose methotrexate use. 61
19895533 2009
38
Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma. 61
19390950 2009
39
Port site and distant metastases of gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography. 61
19009666 2008
40
Radical surgery for advanced squamous cell carcinoma of the gallbladder: a report of three cases, including a 10-year survivor. 61
17523272 2007
41
Adenosquamous/squamous cell carcinoma of the gallbladder. 61
17262729 2007
42
Squamous and adenosquamous cell carcinomas of the gallbladder. 61
15943044 2005
43
Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible. 61
12115390 2002
44
Squamous cell carcinoma of the gallbladder. 61
11175625 2001
45
Hepatopancreatoduodenectomy for squamous cell carcinoma of the gallbladder. 61
11020855 2000
46
Fine needle aspiration cytodiagnosis of primary squamous cell carcinoma of the gallbladder. Report of two cases. 61
10834014 2000
47
Minute squamous cell carcinoma of the gallbladder: a case report. 61
10770570 2000
48
A case of primary adenosquamous/squamous cell carcinoma of gallbladder directly invaded duodenum. 61
10228793 1999
49
[Squamous carcinoma of the gallbladder. Anatomo-clinical study of a case with reference to oncogene expression]. 61
9312737 1997
50
[Squamous cell carcinoma of the gallbladder]. 61
8705496 1996

Variations for Gallbladder Squamous Cell Carcinoma

Expression for Gallbladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gallbladder Squamous Cell Carcinoma.

Pathways for Gallbladder Squamous Cell Carcinoma

Pathways related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.15 CEACAM5 CD109
2 10.75 FGF4 FGF3
3 10.26 FGF4 FGF3

GO Terms for Gallbladder Squamous Cell Carcinoma

Biological processes related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell migration GO:0030334 9.16 FGF4 FGF3
2 fibroblast growth factor receptor signaling pathway GO:0008543 8.96 FGF4 FGF3
3 positive regulation of cell division GO:0051781 8.62 FGF4 FGF3

Molecular functions related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor binding GO:0005104 8.62 FGF4 FGF3

Sources for Gallbladder Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....