MCID: GNG008
MIFTS: 44

Ganglioneuroblastoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Ganglioneuroblastoma

MalaCards integrated aliases for Ganglioneuroblastoma:

Name: Ganglioneuroblastoma 12 59 29 55 44 15 73

Characteristics:

Orphanet epidemiological data:

59
ganglioneuroblastoma
Inheritance: Not applicable; Age of onset: Childhood,Infancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4163
MeSH 44 D018305
NCIt 50 C3790
Orphanet 59 ORPHA251877
ICD10 via Orphanet 34 C71.9
UMLS via Orphanet 74 C0206718
UMLS 73 C0206718

Summaries for Ganglioneuroblastoma

MalaCards based summary : Ganglioneuroblastoma is related to nodular ganglioneuroblastoma and carcinoid syndrome. An important gene associated with Ganglioneuroblastoma is WASF3 (WAS Protein Family Member 3), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Busulfan and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and adrenal gland, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 76 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion... more...

Related Diseases for Ganglioneuroblastoma

Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 nodular ganglioneuroblastoma 31.3 ENO2 MYCN NTRK2 SYP
2 carcinoid syndrome 29.2 ENO2 SYP
3 cystic teratoma 29.2 ENO2 SYP
4 ganglioglioma 28.7 ENO2 SYP
5 hirschsprung disease 1 28.6 PHOX2B SYP VIP
6 pheochromocytoma 28.4 ENO2 NTRK1 SYP VIP
7 neuroblastoma 26.5 ENO2 MYCN NTRK1 NTRK2 PHOX2B SYP
8 ganglioneuroma 26.3 ENO2 GALP MYCN NTRK1 NTRK2 SYP
9 hirschsprung disease ganglioneuroblastoma 12.0
10 peripheral nervous system ganglioneuroblastoma 11.9
11 mediastinum ganglioneuroblastoma 11.9
12 adrenal gland ganglioneuroblastoma 11.9
13 intermixed schwannian stroma-rich ganglioneuroblastoma 11.8
14 stroma-dominant and stroma-poor composite ganglioneuroblastoma 11.8
15 schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma 11.8
16 central hypoventilation syndrome, congenital 11.0
17 adrenal neuroblastoma 10.3 ENO2 MYCN
18 cervical neuroblastoma 10.2 MYCN VIP
19 extracranial neuroblastoma 10.2 MYCN VIP
20 diarrhea 10.2
21 bone ewing's sarcoma 10.1 ENO2 MYCN
22 somatostatinoma 10.1 ENO2 VIP
23 pericardium cancer 10.1 ENO2 MYCN
24 cervicitis 10.1
25 sudden infant death syndrome 10.0 HTR1A NTRK2 PHOX2B
26 diffuse pulmonary fibrosis 10.0 ENO2 VIP
27 mediastinitis 10.0
28 extraosseous ewing's sarcoma 10.0 ENO2 MYCN
29 desmoplastic infantile ganglioglioma 10.0 MYCN SYP
30 ureter small cell carcinoma 10.0 ENO2 SYP
31 hereditary sensory neuropathy 10.0 NTRK1 NTRK2
32 malignant sertoli cell tumor 10.0 ENO2 SYP
33 cerebritis 10.0
34 neuronitis 10.0
35 paraneoplastic syndromes 10.0
36 urinary bladder small cell neuroendocrine carcinoma 10.0 ENO2 SYP
37 auditory system cancer 9.9 ENO2 SYP
38 sinonasal undifferentiated carcinoma 9.9 ENO2 SYP
39 sensory organ benign neoplasm 9.9 ENO2 SYP
40 gallbladder small cell carcinoma 9.9 ENO2 SYP
41 pancreatic somatostatinoma 9.9 ENO2 SYP
42 cutaneous ganglioneuroma 9.9 ENO2 SYP
43 extrahepatic bile duct adenocarcinoma 9.9 ENO2 SYP
44 small cell carcinoma of the bladder 9.9 ENO2 SYP
45 papillary tumor of the pineal region 9.9 ENO2 SYP
46 orbital cancer 9.9 ENO2 SYP
47 middle ear adenoma 9.9 ENO2 SYP
48 ovarian carcinosarcoma 9.9 ENO2 SYP
49 pulmonary large cell neuroendocrine carcinoma 9.9 ENO2 SYP
50 atypical follicular adenoma 9.9 ENO2 SYP

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to Ganglioneuroblastoma

Symptoms & Phenotypes for Ganglioneuroblastoma

MGI Mouse Phenotypes related to Ganglioneuroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 GALP HTR1A MYCN NTRK1 NTRK2 PHOX2B
2 nervous system MP:0003631 9.7 ENO2 HTR1A MYCN NTRK1 NTRK2 PHOX2B
3 normal MP:0002873 9.43 MYCN NTRK1 NTRK2 PHOX2B SYP VIP
4 respiratory system MP:0005388 9.02 ENO2 MYCN NTRK2 PHOX2B VIP

Drugs & Therapeutics for Ganglioneuroblastoma

Drugs for Ganglioneuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 3,Not Applicable 55-98-1 2478
2
Cisplatin Approved Phase 3,Not Applicable 15663-27-1 84093 441203 2767
3
Cyclophosphamide Approved, Investigational Phase 3,Not Applicable 50-18-0, 6055-19-2 2907
4
Doxorubicin Approved, Investigational Phase 3,Not Applicable 23214-92-8 31703
5
Etoposide Approved Phase 3,Not Applicable 33419-42-0 36462
6
Iodine Approved, Investigational Phase 3,Not Applicable 7553-56-2 807
7
Isotretinoin Approved Phase 3,Not Applicable 4759-48-2 5538 5282379
8
Mechlorethamine Approved, Investigational Phase 3,Not Applicable 51-75-2 4033
9
Melphalan Approved Phase 3,Not Applicable 148-82-3 4053 460612
10
Topotecan Approved, Investigational Phase 3,Not Applicable 119413-54-6, 123948-87-8 60700
11
Vincristine Approved, Investigational Phase 3,Not Applicable 2068-78-2, 57-22-7 5978
12
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
13
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
14
Crizotinib Approved Phase 3 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
16
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
17
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
19
Doxil Approved June 1999 Phase 3,Not Applicable 31703
20 3-Iodobenzylguanidine Phase 3,Not Applicable
21 Alkylating Agents Phase 3,Phase 2,Not Applicable
22 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
23 Antibiotics, Antitubercular Phase 3,Phase 2,Not Applicable
24 Antimitotic Agents Phase 3,Not Applicable
25 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
26 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Not Applicable
27 Antirheumatic Agents Phase 3,Not Applicable
28 cadexomer iodine Phase 3,Not Applicable
29 Dermatologic Agents Phase 3,Not Applicable
30 Etoposide phosphate Phase 3,Not Applicable
31 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
32 Radiopharmaceuticals Phase 3,Not Applicable
33 topoisomerase I inhibitors Phase 3,Phase 2,Not Applicable
34 Topoisomerase Inhibitors Phase 3,Phase 2,Not Applicable
35 Analgesics Phase 3
36 Analgesics, Non-Narcotic Phase 3
37 Antibodies Phase 3,Phase 2
38 Antibodies, Monoclonal Phase 3,Phase 2
39 Anti-HIV Agents Phase 3
40 Anti-Infective Agents Phase 3,Phase 2
41 Anti-Retroviral Agents Phase 3
42 Antiviral Agents Phase 3
43 Immunoglobulins Phase 3,Phase 2
44 Interleukin-2 Phase 3
45 Keratolytic Agents Phase 3
46 Nitrogen Mustard Compounds Phase 3
47 Peripheral Nervous System Agents Phase 3
48 Protective Agents Phase 3
49 Protein Kinase Inhibitors Phase 3
50 razoxane Phase 3

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Testing the Addition of 131I-MIBG or Crizotinib to Intensive Therapy in People With High-risk Neuroblastoma (NBL) Recruiting NCT03126916 Phase 3 Busulfan;Carboplatin;Cisplatin;Crizotinib;Cyclophosphamide;Dexrazoxane Hydrochloride;Doxorubicin Hydrochloride;Etoposide Phosphate;Isotretinoin;Melphalan;Thiotepa;Topotecan Hydrochloride;Vincristine Sulfate
2 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3 chemotherapy
3 Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma Recruiting NCT02176967 Phase 3 Carboplatin;Etoposide;Cyclophosphamide;Doxorubicin Hydrochloride
4 Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Active, not recruiting NCT01767194 Phase 2 Irinotecan Hydrochloride;Temozolomide;Temsirolimus
5 Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01 Recruiting NCT02311621 Phase 1
6 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
7 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Unknown status NCT02559804
8 Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Completed NCT01175356 Not Applicable cyclophosphamide;topotecan hydrochloride;cisplatin;etoposide phosphate;vincristine sulfate;doxorubicin hydrochloride;busulfan;melphalan;isotretinoin
9 Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Recruiting NCT00904241
10 Phase II Study of Proton Radiation Therapy for Neuroblastoma Recruiting NCT02112617 Not Applicable
11 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroblastoma

Cochrane evidence based reviews: ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

Genetic tests related to Ganglioneuroblastoma:

# Genetic test Affiliating Genes
1 Ganglioneuroblastoma 29

Anatomical Context for Ganglioneuroblastoma

MalaCards organs/tissues related to Ganglioneuroblastoma:

41
Brain, Spinal Cord, Adrenal Gland, Testes, Bone, Lung, Kidney

Publications for Ganglioneuroblastoma

Articles related to Ganglioneuroblastoma:

(show top 50) (show all 249)
# Title Authors Year
1
Cervical ganglioneuroblastoma in a new born Japanese Black calf. ( 29526867 )
2018
2
Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents. ( 29369484 )
2018
3
Usefulness of fluorodeoxyglucose positron emission tomography/computed tomography for detection ofA a neuroblastic nodule in aA ganglioneuroblastoma: a case report. ( 29720264 )
2018
4
Pediatric Supratentorial Ganglioneuroblastoma: Case Report and Review of Literature. ( 29496580 )
2018
5
Lymphnode tuberculosis in a 4-year-old boy with relapsed ganglioneuroblastoma: a case report. ( 29506484 )
2018
6
Primary cervical ganglioneuroblastoma: A case report. ( 29561407 )
2018
7
Adrenal Ganglioneuroblastoma in an Adult: A Rare Case Report. ( 29696040 )
2018
8
Ganglioneuroblastoma Arising in an Ovarian Dermoid Cyst: First Report in the Literature. ( 28914675 )
2017
9
Hitherto unseen survival in an ALK-positive-patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine. ( 29225862 )
2017
10
Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. ( 28608056 )
2017
11
Adrenal ganglioneuroblastoma in an adult. ( 28922691 )
2017
12
Adult hippocampal ganglioneuroblastoma: Case report and literature review. ( 29390424 )
2017
13
Adrenal Ganglioneuroblastoma in Adults: A Case Report and Review of the Literature. ( 28713603 )
2017
14
Ganglioneuroblastoma in a newborn with multiple metastases: a case report. ( 28847309 )
2017
15
A case report of the first ganglioneuroblastoma of the parotid gland of an the adult. ( 28630389 )
2017
16
Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma. ( 28465480 )
2017
17
Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland. ( 27980262 )
2016
18
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. ( 27465021 )
2016
19
Intraparenchymal Spinal Cord Ganglioneuroblastoma Originating from the Peripheral Sympathetic Nervous System in a Cat. ( 26799733 )
2016
20
Ganglioneuroblastoma: Unusual presentation as a pleural mass mimicking mesothelioma. ( 27051110 )
2016
21
A Rare Tumor in the Cervical Sympathetic Trunk: Ganglioneuroblastoma. ( 27965907 )
2016
22
Role of radiotherapy in adult ganglioneuroblastoma and ganglioneuroma. ( 27569100 )
2016
23
Ganglioneuroblastoma during pregnancy--A rare case report. ( 27132425 )
2016
24
A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma. ( 27526309 )
2016
25
Ganglioneuroblastoma of Skull Base. ( 26435974 )
2015
26
Adult adrenal ganglioneuroblastoma: A rare case report. ( 25737766 )
2015
27
Adult onset of ganglioneuroblastoma of the adrenal gland: case report and review of the literature. ( 26380803 )
2015
28
A malignant transformation of a spinal epidural mass from ganglioneuroblastoma to neuroblastoma. ( 25810863 )
2015
29
Primary cervical ganglioneuroblastoma. ( 25921075 )
2015
30
Onset of adrenal ganglioneuroblastoma in an adult after delivery. ( 26448921 )
2015
31
Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma. ( 25985452 )
2015
32
Primary extradural spinal ganglioneuroblastoma: a case report. ( 24831370 )
2014
33
Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. ( 25207191 )
2014
34
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. ( 25081755 )
2014
35
Ganglioneuroblastoma of filum terminale: case report. ( 24878272 )
2014
36
Review of our experience with neuroblastoma and ganglioneuroblastoma in adults. ( 25002244 )
2014
37
Pediatric cerebral ganglioneuroblastoma. ( 25216629 )
2014
38
Approach to one lung ventilation during the surgical resection of an intrathoracic ganglioneuroblastoma in a three-year-old child: a case report and review of the literature. ( 24988827 )
2014
39
Anti-Hu-associated brainstem encephalitis with ganglioneuroblastoma in a young adult. ( 25099509 )
2014
40
Transformation of Merkel cell carcinoma to ganglioneuroblastoma in intracranial metastasis. ( 24996688 )
2014
41
First reported case of ganglioneuroblastoma in pregnancy and a review of the literature. ( 27512439 )
2014
42
Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. ( 24887835 )
2013
43
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours. ( 23835063 )
2013
44
Recurrent multiple spinal paragangliomas as a manifestation of a metastatic composite paraganglioma-ganglioneuroblastoma. ( 23532344 )
2013
45
Ganglioneuroblastoma arising within a retroperitoneal mature cystic teratoma. ( 23293755 )
2012
46
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. ( 22510501 )
2012
47
Lytic and sclerotic (mixed) vertebral metastasis in ganglioneuroblastoma. ( 23723589 )
2012
48
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. ( 23080230 )
2012
49
Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. ( 22137163 )
2012
50
High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. ( 22203052 )
2012

Variations for Ganglioneuroblastoma

Expression for Ganglioneuroblastoma

Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for Ganglioneuroblastoma

Pathways related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 ENO2 HTR1A MYCN NTRK1 NTRK2 SYP
2 11.54 HTR1A NTRK2 PHOX2B
3 10.91 NTRK1 NTRK2
4
Show member pathways
10 NTRK1 NTRK2

GO Terms for Ganglioneuroblastoma

Biological processes related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.56 HTR1A MYCN NTRK2 VIP
2 cellular response to nerve growth factor stimulus GO:1990090 9.32 NTRK1 NTRK2
3 sympathetic nervous system development GO:0048485 9.16 NTRK1 PHOX2B
4 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
5 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
2 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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