MCID: GNG008
MIFTS: 44

Ganglioneuroblastoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ganglioneuroblastoma

MalaCards integrated aliases for Ganglioneuroblastoma:

Name: Ganglioneuroblastoma 12 59 29 55 44 15 73

Characteristics:

Orphanet epidemiological data:

59
ganglioneuroblastoma
Inheritance: Not applicable; Age of onset: Childhood,Infancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4163
MeSH 44 D018305
NCIt 50 C3790
SNOMED-CT 68 69515008
Orphanet 59 ORPHA251877
ICD10 via Orphanet 34 C71.9
UMLS via Orphanet 74 C0206718
UMLS 73 C0206718

Summaries for Ganglioneuroblastoma

MalaCards based summary : Ganglioneuroblastoma is related to nodular ganglioneuroblastoma and pheochromocytoma. An important gene associated with Ganglioneuroblastoma is WASF3 (WAS Protein Family Member 3), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Busulfan and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, adrenal gland and bone, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 76 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion... more...

Related Diseases for Ganglioneuroblastoma

Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 nodular ganglioneuroblastoma 32.8 ENO2 MYCN NTRK2 SYP
2 pheochromocytoma 29.9 ENO2 NTRK1 SYP VIP
3 ganglioglioma 29.7 ENO2 SYP
4 carcinoid syndrome 29.6 ENO2 SYP
5 cystic teratoma 29.6 ENO2 SYP
6 neuroblastoma 29.6 ENO2 MYCN NTRK1 NTRK2 PHOX2B SYP
7 malignant pheochromocytoma 29.6 ENO2 SYP
8 hirschsprung disease 1 29.5 PHOX2B SYP VIP
9 ganglioneuroma 29.4 ENO2 GALP MYCN NTRK1 NTRK2 SYP
10 hirschsprung disease ganglioneuroblastoma 12.1
11 peripheral nervous system ganglioneuroblastoma 12.1
12 mediastinum ganglioneuroblastoma 12.0
13 adrenal gland ganglioneuroblastoma 12.0
14 intermixed schwannian stroma-rich ganglioneuroblastoma 12.0
15 stroma-dominant and stroma-poor composite ganglioneuroblastoma 12.0
16 schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma 12.0
17 central hypoventilation syndrome, congenital 11.1
18 diarrhea 10.3
19 adrenal neuroblastoma 10.1 ENO2 MYCN
20 cervical neuroblastoma 10.1 MYCN VIP
21 extracranial neuroblastoma 10.1 MYCN VIP
22 causalgia 10.1 ENO2 NTRK1
23 somatostatinoma 10.1 ENO2 VIP
24 bone ewing's sarcoma 10.0 ENO2 MYCN
25 pericardium cancer 10.0 ENO2 MYCN
26 sudden infant death syndrome 10.0 HTR1A NTRK2 PHOX2B
27 diffuse pulmonary fibrosis 10.0 ENO2 VIP
28 nervous system benign neoplasm 10.0 ENO2 SYP
29 large cell neuroendocrine carcinoma 10.0 ENO2 SYP
30 extraosseous ewing's sarcoma 10.0 ENO2 MYCN
31 carotid body cancer 10.0 ENO2 SYP
32 desmoplastic infantile ganglioglioma 10.0 MYCN SYP
33 malignant sertoli cell tumor 10.0 ENO2 SYP
34 urinary bladder small cell neuroendocrine carcinoma 10.0 ENO2 SYP
35 auditory system cancer 10.0 ENO2 SYP
36 sinonasal undifferentiated carcinoma 10.0 ENO2 SYP
37 gallbladder small cell carcinoma 10.0 ENO2 SYP
38 pancreatic somatostatinoma 10.0 ENO2 SYP
39 wilms tumor 6 10.0
40 paraganglioma 10.0
41 osteomalacia 10.0
42 conn's syndrome 10.0
43 turner syndrome 10.0
44 hypokalemia 10.0
45 myoclonus 10.0
46 paraneoplastic syndromes 10.0
47 cutaneous ganglioneuroma 10.0 ENO2 SYP
48 extrahepatic bile duct adenocarcinoma 10.0 ENO2 SYP
49 small cell carcinoma of the bladder 10.0 ENO2 SYP
50 papillary tumor of the pineal region 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to Ganglioneuroblastoma

Symptoms & Phenotypes for Ganglioneuroblastoma

MGI Mouse Phenotypes related to Ganglioneuroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ENO2 GALP HTR1A MYCN NTRK1 NTRK2
2 nervous system MP:0003631 9.7 ENO2 HTR1A MYCN NTRK1 NTRK2 PHOX2B
3 normal MP:0002873 9.43 MYCN NTRK1 NTRK2 PHOX2B SYP VIP
4 respiratory system MP:0005388 9.02 ENO2 MYCN NTRK2 PHOX2B VIP

Drugs & Therapeutics for Ganglioneuroblastoma

Drugs for Ganglioneuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 3,Not Applicable 55-98-1 2478
2
Vincristine Approved, Investigational Phase 3,Not Applicable 57-22-7, 2068-78-2 5978
3
Cyclophosphamide Approved, Investigational Phase 3,Not Applicable 6055-19-2, 50-18-0 2907
4
Mechlorethamine Approved, Investigational Phase 3,Not Applicable 51-75-2 4033
5
Topotecan Approved, Investigational Phase 3,Not Applicable 123948-87-8, 119413-54-6 60700
6
Iodine Approved, Investigational Phase 3,Not Applicable 7553-56-2 807
7
Cisplatin Approved Phase 3,Not Applicable 15663-27-1 2767 441203 84093
8
Etoposide Approved Phase 3,Not Applicable 33419-42-0 36462
9
Melphalan Approved Phase 3,Not Applicable 148-82-3 4053 460612
10
Doxorubicin Approved, Investigational Phase 3,Not Applicable 23214-92-8 31703
11
Isotretinoin Approved Phase 3,Not Applicable 4759-48-2 5538 5282379
12
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
13
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
14
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
15
Crizotinib Approved Phase 3 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
17
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
18
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
19
Doxil Approved June 1999 Phase 3,Not Applicable 31703
20 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
21 Alkylating Agents Phase 3,Phase 2,Not Applicable
22 Immunoglobulins Phase 3,Phase 2
23 Antirheumatic Agents Phase 3,Not Applicable
24 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
25 Antibiotics, Antitubercular Phase 3,Phase 2,Not Applicable
26 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
27 Antibodies, Monoclonal Phase 3,Phase 2
28 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
29 phenylalanine Phase 3,Not Applicable
30 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
31 Anti-Infective Agents Phase 3,Phase 2,Phase 1
32 Antimitotic Agents Phase 3,Not Applicable
33 cadexomer iodine Phase 3,Not Applicable
34 3-Iodobenzylguanidine Phase 3,Not Applicable
35 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
36 Etoposide phosphate Phase 3,Not Applicable
37 Dermatologic Agents Phase 3,Not Applicable
38 Antibodies Phase 3,Phase 2
39 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
40 Radiopharmaceuticals Phase 3,Not Applicable
41 Analgesics Phase 3
42 Antiviral Agents Phase 3,Phase 1
43 alanine Phase 3
44 Peripheral Nervous System Agents Phase 3
45 Keratolytic Agents Phase 3
46 Anti-HIV Agents Phase 3
47 Vitamins Phase 3
48 Retinol palmitate Phase 3
49 retinol Phase 3
50 tyrosine Phase 3

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma Recruiting NCT03126916 Phase 3 Busulfan;Carboplatin;Cisplatin;Crizotinib;Cyclophosphamide;Dexrazoxane Hydrochloride;Doxorubicin Hydrochloride;Etoposide Phosphate;Isotretinoin;Melphalan;Thiotepa;Topotecan Hydrochloride;Vincristine Sulfate
2 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3 chemotherapy
3 Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma Recruiting NCT02176967 Phase 3 Carboplatin;Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide
4 Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Completed NCT01767194 Phase 2 Irinotecan Hydrochloride;Temozolomide;Temsirolimus
5 Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant Recruiting NCT03786783 Phase 2 Carboplatin;Cisplatin;Cyclophosphamide;Dexrazoxane;Doxorubicin;Etoposide;Isotretinoin;Melphalan;Thiotepa;Topotecan;Vincristine
6 Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Recruiting NCT02095132 Phase 1, Phase 2 Adavosertib;Irinotecan Hydrochloride
7 Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma Not yet recruiting NCT03794349 Phase 2 Eflornithine;Irinotecan;Temozolomide
8 Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01 Recruiting NCT02311621 Phase 1
9 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
10 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Unknown status NCT02559804
11 Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Completed NCT01175356 Not Applicable cyclophosphamide;topotecan hydrochloride;cisplatin;etoposide phosphate;vincristine sulfate;doxorubicin hydrochloride;busulfan;melphalan;isotretinoin
12 Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Recruiting NCT00904241
13 Phase II Study of Proton Radiation Therapy for Neuroblastoma Recruiting NCT02112617 Not Applicable
14 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroblastoma

Cochrane evidence based reviews: ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

Genetic tests related to Ganglioneuroblastoma:

# Genetic test Affiliating Genes
1 Ganglioneuroblastoma 29

Anatomical Context for Ganglioneuroblastoma

MalaCards organs/tissues related to Ganglioneuroblastoma:

41
Brain, Adrenal Gland, Bone, Lung, Cerebellum, Spinal Cord, Myeloid

Publications for Ganglioneuroblastoma

Articles related to Ganglioneuroblastoma:

(show top 50) (show all 255)
# Title Authors Year
1
Cervical ganglioneuroblastoma in a new born Japanese Black calf. ( 29526867 )
2018
2
Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents. ( 29369484 )
2018
3
Usefulness of fluorodeoxyglucose positron emission tomography/computed tomography for detection ofA a neuroblastic nodule in aA ganglioneuroblastoma: a case report. ( 29720264 )
2018
4
Pediatric Supratentorial Ganglioneuroblastoma: Case Report and Review of Literature. ( 29496580 )
2018
5
Lymphnode tuberculosis in a 4-year-old boy with relapsed ganglioneuroblastoma: a case report. ( 29506484 )
2018
6
Primary cervical ganglioneuroblastoma: A case report. ( 29561407 )
2018
7
Adrenal Ganglioneuroblastoma in an Adult: A Rare Case Report. ( 29696040 )
2018
8
Corrigendum to Pediatric Supratentorial Ganglioneuroblastoma: Case Report and Review of Literature [World Neurosurgery 113 (2018) 261-266]. ( 30120073 )
2018
9
Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report. ( 30225726 )
2018
10
Ganglioneuroblastoma Arising in an Ovarian Dermoid Cyst: First Report in the Literature. ( 28914675 )
2017
11
Hitherto unseen survival in an ALK-positive-patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine. ( 29225862 )
2017
12
Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. ( 28608056 )
2017
13
Adrenal ganglioneuroblastoma in an adult. ( 28922691 )
2017
14
Adult hippocampal ganglioneuroblastoma: Case report and literature review. ( 29390424 )
2017
15
Adrenal Ganglioneuroblastoma in Adults: A Case Report and Review of the Literature. ( 28713603 )
2017
16
Ganglioneuroblastoma in a newborn with multiple metastases: a case report. ( 28847309 )
2017
17
A case report of the first ganglioneuroblastoma of the parotid gland of an the adult. ( 28630389 )
2017
18
Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma. ( 28465480 )
2017
19
Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland. ( 27980262 )
2016
20
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. ( 27465021 )
2016
21
Intraparenchymal Spinal Cord Ganglioneuroblastoma Originating from the Peripheral Sympathetic Nervous System in a Cat. ( 26799733 )
2016
22
Ganglioneuroblastoma: Unusual presentation as a pleural mass mimicking mesothelioma. ( 27051110 )
2016
23
A Rare Tumor in the Cervical Sympathetic Trunk: Ganglioneuroblastoma. ( 27965907 )
2016
24
Role of radiotherapy in adult ganglioneuroblastoma and ganglioneuroma. ( 27569100 )
2016
25
Ganglioneuroblastoma during pregnancy--A rare case report. ( 27132425 )
2016
26
A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma. ( 27526309 )
2016
27
Ganglioneuroblastoma of Skull Base. ( 26435974 )
2015
28
Adult adrenal ganglioneuroblastoma: A rare case report. ( 25737766 )
2015
29
Adult onset of ganglioneuroblastoma of the adrenal gland: case report and review of the literature. ( 26380803 )
2015
30
A malignant transformation of a spinal epidural mass from ganglioneuroblastoma to neuroblastoma. ( 25810863 )
2015
31
Primary cervical ganglioneuroblastoma. ( 25921075 )
2015
32
Onset of adrenal ganglioneuroblastoma in an adult after delivery. ( 26448921 )
2015
33
Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma. ( 25985452 )
2015
34
Primary extradural spinal ganglioneuroblastoma: a case report. ( 24831370 )
2014
35
Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. ( 25207191 )
2014
36
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. ( 25081755 )
2014
37
Ganglioneuroblastoma of filum terminale: case report. ( 24878272 )
2014
38
Review of our experience with neuroblastoma and ganglioneuroblastoma in adults. ( 25002244 )
2014
39
Pediatric cerebral ganglioneuroblastoma. ( 25216629 )
2014
40
Approach to one lung ventilation during the surgical resection of an intrathoracic ganglioneuroblastoma in a three-year-old child: a case report and review of the literature. ( 24988827 )
2014
41
Anti-Hu-associated brainstem encephalitis with ganglioneuroblastoma in a young adult. ( 25099509 )
2014
42
Transformation of Merkel cell carcinoma to ganglioneuroblastoma in intracranial metastasis. ( 24996688 )
2014
43
First reported case of ganglioneuroblastoma in pregnancy and a review of the literature. ( 27512439 )
2014
44
Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. ( 24887835 )
2013
45
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours. ( 23835063 )
2013
46
Recurrent multiple spinal paragangliomas as a manifestation of a metastatic composite paraganglioma-ganglioneuroblastoma. ( 23532344 )
2013
47
Ganglioneuroblastoma arising within a retroperitoneal mature cystic teratoma. ( 23293755 )
2012
48
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. ( 22510501 )
2012
49
Lytic and sclerotic (mixed) vertebral metastasis in ganglioneuroblastoma. ( 23723589 )
2012
50
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. ( 23080230 )
2012

Variations for Ganglioneuroblastoma

Expression for Ganglioneuroblastoma

Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for Ganglioneuroblastoma

Pathways related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 ENO2 HTR1A MYCN NTRK1 NTRK2 SYP
2 11.65 HTR1A NTRK2 PHOX2B
3 10.97 NTRK1 NTRK2
4 10.79 NTRK1 NTRK2 VIP
5
Show member pathways
10.2 NTRK1 NTRK2

GO Terms for Ganglioneuroblastoma

Cellular components related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 8.62 NTRK2 SYP

Biological processes related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to nerve growth factor stimulus GO:1990090 9.32 NTRK1 NTRK2
2 neurotrophin TRK receptor signaling pathway GO:0048011 9.26 NTRK1 NTRK2
3 sympathetic nervous system development GO:0048485 9.16 NTRK1 PHOX2B
4 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
5 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
2 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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