MCID: GNG002
MIFTS: 51

Ganglioneuroma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ganglioneuroma

MalaCards integrated aliases for Ganglioneuroma:

Name: Ganglioneuroma 12 59 29 55 15 73

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4817
MeSH 44 D005729
NCIt 50 C42065 C6934
Orphanet 59 ORPHA251992
UMLS via Orphanet 74 C0017075
ICD10 via Orphanet 34 D36.1

Summaries for Ganglioneuroma

Disease Ontology : 12 An autonomic nervous system benign neoplasm that is characterized by the presence of mature ganglion cells and a mature Schwannian stroma and arises from the sympathetic trunk in the mediastinum.

MalaCards based summary : Ganglioneuroma is related to cutaneous ganglioneuroma and neuroblastoma, and has symptoms including seizures An important gene associated with Ganglioneuroma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Tyrosine Kinases / Adaptors. The drugs Vincristine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, colon and bone, and related phenotypes are hypertension and gastrointestinal hemorrhage

Wikipedia : 76 Ganglioneuroma is a rare and benign tumor of the autonomic nerve fibers arising from neural crest... more...

Related Diseases for Ganglioneuroma

Diseases related to Ganglioneuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 cutaneous ganglioneuroma 33.5 ENO2 NCAM1 SYP
2 neuroblastoma 31.3 ENO2 MYCN NCAM1 NTRK1 NTRK2 SYP
3 paraganglioma 30.1 CHGA ENO2 RET SYP
4 cystic teratoma 29.9 ENO2 GFAP SYP
5 teratoma 29.9 ENO2 GFAP SYP
6 ganglioneuroblastoma 29.8 ENO2 GALP MYCN NTRK1 NTRK2 SYP
7 ependymoma 29.7 ENO2 GFAP SYP
8 pheochromocytoma 29.7 CHGA ENO2 NCAM1 NTRK1 RET SYP
9 malignant pheochromocytoma 29.5 CHGA ENO2 SYP
10 thyroid carcinoma, familial medullary 29.2 CHGA ENO2 NTRK1 RET
11 olfactory neuroblastoma 29.1 CHGA ENO2 NTRK1 NTRK2 SYP
12 gangliocytoma 11.7
13 multiple endocrine neoplasia, type iib 11.5
14 central hypoventilation syndrome, congenital 11.5
15 multiple endocrine neoplasia, type iia 11.4
16 appendix adenocarcinoma 11.0
17 scoliosis 10.3
18 neurofibromatosis, type i 10.3
19 bone benign neoplasm 10.2 ENO2 SYP
20 connective tissue benign neoplasm 10.2 ENO2 SYP
21 mixed cell type cancer 10.2 ENO2 SYP
22 glomus tumor 10.2 ENO2 SYP
23 mucinous ovarian cystadenoma 10.2 ENO2 SYP
24 optic nerve neoplasm 10.2 ENO2 SYP
25 rhabdoid cancer 10.2 ENO2 SYP
26 intraocular retinoblastoma 10.2 ENO2 SYP
27 pineal parenchymal tumor of intermediate differentiation 10.2 ENO2 SYP
28 basaloid squamous cell carcinoma 10.2 ENO2 SYP
29 prostate small cell carcinoma 10.2 ENO2 SYP
30 meningeal melanomatosis 10.2 ENO2 SYP
31 desmoplastic small round cell tumor 10.2 ENO2 SYP
32 extraskeletal ewing sarcoma 10.2 ENO2 SYP
33 papilloma of choroid plexus 10.2 GFAP SYP
34 pineoblastoma 10.2 GFAP SYP
35 childhood oligodendroglioma 10.2 GFAP SYP
36 cerebellopontine angle tumor 10.2 GFAP SYP
37 anaplastic ependymoma 10.2 GFAP SYP
38 fetal alcohol syndrome 10.2 GFAP VIP
39 sweat gland disease 10.2 GFAP NTRK1
40 ectopic cushing syndrome 10.2 RET SYP
41 spermatocele 10.2 NCAM1 SYP
42 carotid body cancer 10.2 ENO2 SYP
43 malignant sertoli cell tumor 10.2 ENO2 SYP
44 traumatic brain injury 10.2 ENO2 GFAP
45 granular cell tumor 10.2 ENO2 GFAP
46 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
47 dysgerminoma of ovary 10.2 ENO2 GFAP
48 juvenile pilocytic astrocytoma 10.2 ENO2 GFAP
49 extraventricular neurocytoma 10.2 GFAP SYP
50 pancreatic somatostatinoma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Ganglioneuroma:



Diseases related to Ganglioneuroma

Symptoms & Phenotypes for Ganglioneuroma

Human phenotypes related to Ganglioneuroma:

59 32 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0000822
2 gastrointestinal hemorrhage 59 32 very rare (1%) Very rare (<4-1%) HP:0002239
3 episodic abdominal pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0002574
4 colorectal polyposis 59 32 frequent (33%) Frequent (79-30%) HP:0200063
5 hamartomatous polyposis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004390
6 central hypoventilation 59 32 very rare (1%) Very rare (<4-1%) HP:0007110
7 abnormal bone structure 59 32 very rare (1%) Very rare (<4-1%) HP:0003330
8 functional intestinal obstruction 59 32 occasional (7.5%) Occasional (29-5%) HP:0005249
9 ganglioneuroma 59 32 obligate (100%) Obligate (100%) HP:0003005
10 neoplasm of the adrenal gland 59 32 occasional (7.5%) Occasional (29-5%) HP:0100631
11 abnormality of the mediastinum 59 32 frequent (33%) Frequent (79-30%) HP:0045026
12 multiple intestinal neurofibromatosis 59 32 frequent (33%) Frequent (79-30%) HP:0005220
13 abnormality of the orbital region 59 32 very rare (1%) Very rare (<4-1%) HP:0000315
14 abnormality of the prostate 59 32 very rare (1%) Very rare (<4-1%) HP:0008775
15 abnormality of the adrenal glands 59 Frequent (79-30%)
16 abnormality of the rectum 59 Very rare (<4-1%)

UMLS symptoms related to Ganglioneuroma:


seizures

GenomeRNAi Phenotypes related to Ganglioneuroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell viability after pRB stimulation GR00230-A-1 8.8 NTRK1 NTRK2 RET

MGI Mouse Phenotypes related to Ganglioneuroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ENO2 GALP GFAP MYCN NCAM1 NTRK1
2 growth/size/body region MP:0005378 9.86 CHGA ENO2 GALP GFAP MYCN NTRK1
3 nervous system MP:0003631 9.81 CHGA ENO2 GFAP MYCN NCAM1 NTRK1
4 normal MP:0002873 9.5 GFAP MYCN NTRK1 NTRK2 RET SYP
5 vision/eye MP:0005391 9.1 GFAP MYCN NCAM1 NTRK1 NTRK2 VIP

Drugs & Therapeutics for Ganglioneuroma

Drugs for Ganglioneuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
2
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
3
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
4
Trametinib Approved Phase 2 871700-17-3 11707110
5 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
6 Protein Kinase Inhibitors Phase 2
7 Antimitotic Agents Phase 2
8
Bevacizumab Approved, Investigational Phase 1 216974-75-3
9
Irinotecan Approved, Investigational Phase 1 100286-90-6, 97682-44-5 60838
10
Camptothecin Experimental Phase 1 7689-03-4
11 topoisomerase I inhibitors Phase 1
12 Angiogenesis Inhibitors Phase 1
13 Angiogenesis Modulating Agents Phase 1
14 Topoisomerase Inhibitors Phase 1
15
Octreotide Approved, Investigational 83150-76-9 383414 6400441
16 Edotreotide
17 Antineoplastic Agents, Hormonal
18 Fluorodeoxyglucose F18
19 Radiopharmaceuticals
20 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib;Carboplatin with vincristine
2 Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed NCT01999270 Phase 1 Irinotecan;Bevacizumab
3 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Unknown status NCT02559804
4 DOTATOC PET/CT for Imaging NET Patients Recruiting NCT03583528
5 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroma

Genetic Tests for Ganglioneuroma

Genetic tests related to Ganglioneuroma:

# Genetic test Affiliating Genes
1 Ganglioneuroma 29

Anatomical Context for Ganglioneuroma

MalaCards organs/tissues related to Ganglioneuroma:

41
Adrenal Gland, Colon, Bone, Ovary, Prostate, Lung, Pineal

Publications for Ganglioneuroma

Articles related to Ganglioneuroma:

(show top 50) (show all 652)
# Title Authors Year
1
Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents. ( 29369484 )
2018
2
Left adrenal ganglioneuroma: Report of a new case. ( 29631229 )
2018
3
Intraoperative Nerve Monitoring in Robotic-Assisted Resection Of Presacral Ganglioneuroma: Operative Technique. ( 29554323 )
2018
4
Cervical ganglioneuroma: clinical and radiological features of a rare tumour. ( 29326343 )
2018
5
Massive thoracic ganglioneuroma with significant mass effect on left hemithorax. ( 29437731 )
2018
6
Surgical approach to adrenal ganglioneuroma: Case report and literature review. ( 29974732 )
2018
7
Giant Thoracolumbar Dumbbell Ganglioneuroma. ( 29698954 )
2018
8
A rare cause of chronic ataxia in childhood: ganglioneuroma. ( 29532434 )
2018
9
Primary cutaneous ganglioneuroma: anatomico-clinical study of 4 cases with focus on Merkel cells. ( 29569258 )
2018
10
Adrenal collision tumor (parachordoma and ganglioneuroma): A case report. ( 29844903 )
2018
11
Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population. ( 29383425 )
2018
12
Simultaneous Presentation of Wilms' Tumor and Contralateral Ganglioneuroma in a Child: Case Report and Literature Review. ( 29334535 )
2018
13
Intradural ganglioneuroma mimicking lumbar disc herniation. Case Report. ( 29886296 )
2018
14
Lingual ganglioneuroma in a dog. ( 29367496 )
2018
15
Magnetic resonance neurography in the diagnosis of a retroperitoneal ganglioneuroma: Case report and literature review. ( 29904477 )
2018
16
Extensive spinal extradural ganglioneuroma of the lumbar spine: mimicking lymphoma. ( 29594468 )
2018
17
De Novo Tumors of Teratoma: Ganglioneuroma Arising From a Mature Cystic Teratoma of the Ovary. ( 28700440 )
2018
18
Artery first approach for resecting ganglioneuroma encasing superior mesenteric artery. ( 30093776 )
2018
19
Erratum: Adrenal collision tumor (parachordoma and ganglioneuroma): A case report. ( 30101030 )
2018
20
Rare adrenal ganglioneuroma encasing the inferior vena cava. ( 30117649 )
2018
21
Paediatric parapharyngeal ganglioneuroma. ( 30131403 )
2018
22
Retroperitoneal ganglioneuroma combined with scoliosis: A case report and literature review. ( 30212980 )
2018
23
An unusual cause of chronic back pain: retroperitoneal ganglioneuroma. ( 30290734 )
2018
24
Approach to a Posterior Cervico-mediastinal Ganglioneuroma. ( 30365962 )
2018
25
Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer. ( 28882936 )
2017
26
Ganglioneuroma of the Neck: A case report. ( 29148641 )
2017
27
Adrenal ganglioneuroma: The Padua Endocrine Surgery Unit experience. ( 28506406 )
2017
28
Giant Ganglioneuroma of Thoracic Spine: A Case Report and Review of Literature. ( 28490166 )
2017
29
Ganglioneuroma of the External Auditory Canal and Middle Ear. ( 28875046 )
2017
30
A Case Report of Giant Adrenal Ganglioneuroma. ( 28443238 )
2017
31
Composite paraganglioma-ganglioneuroma concomitant with adrenal metastasis of medullary thyroid carcinoma in a patient with multiple endocrine neoplasia type 2B: A case report. ( 27704704 )
2017
32
Robotic assisted laparoscopic excision of a retroperitoneal Ganglioneuroma. ( 28537695 )
2017
33
Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. ( 28608056 )
2017
34
Bilateral pheochromocytoma with ganglioneuroma component associated with multiple neuroendocrine neoplasia type 2A: a case report. ( 28760150 )
2017
35
Harlequin Syndrome Following Resection of Mediastinal Ganglioneuroma. ( 28382275 )
2017
36
Case report: Robot-assisted laparoscopic excision of giant ganglioneuroma of the adrenal gland. ( 28748502 )
2017
37
Colonic Ganglioneuroma: A Rare Finding during Colorectal Cancer Screening. ( 29033760 )
2017
38
Retroperitoneal Ganglioneuroma Mimicking a Kidney Tumor. Case Report. ( 28607627 )
2017
39
Every polyp is not an adenoma: Ganglioneuroma of the colon. ( 29198570 )
2017
40
Synchronous Ganglioneuroma and Schwannoma Mistaken for Carotid Body Tumor. ( 29147595 )
2017
41
Uveal Ganglioneuroma due to Germline PTEN Mutation (Cowden Syndrome) Presenting as Unilateral Infantile Glaucoma. ( 28868283 )
2017
42
Adrenal ganglioneuroma: What you need to know. ( 29085827 )
2017
43
Ganglioneuroma of the Sacrum. ( 29017308 )
2017
44
Chylothorax after mediastinal ganglioneuroma resection treated with fibrin sealant patch: a case report. ( 29221335 )
2017
45
Composite Pheochromocytoma/Paraganglioma-Ganglioneuroma: A Clinicopathologic Study of Eight Cases with Analysis of Succinate Dehydrogenase. ( 28752484 )
2017
46
Excision of a Presacral Ganglioneuroma in a Young Man. ( 28738920 )
2017
47
Appendiceal ganglioneuroma in neurofibromatosis type 2. ( 28578246 )
2017
48
Giant Ganglioneuroma in a 5-Year Child. ( 28302232 )
2017
49
Intrathoracic ganglioneuroma presenting as an endobronchial mass. ( 28879079 )
2017
50
Trigeminal Ganglioneuroma in the Middle-posterior Cranial Fossa: a Case Report. ( 28693694 )
2017

Variations for Ganglioneuroma

Expression for Ganglioneuroma

Search GEO for disease gene expression data for Ganglioneuroma.

Pathways for Ganglioneuroma

GO Terms for Ganglioneuroma

Cellular components related to Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 NTRK1 NTRK2 RET

Biological processes related to Ganglioneuroma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.78 NTRK1 NTRK2 RET VIP
2 axon guidance GO:0007411 9.67 NCAM1 NTRK1 RET
3 peptidyl-tyrosine phosphorylation GO:0018108 9.63 NTRK1 NTRK2 RET
4 positive regulation of MAPK cascade GO:0043410 9.54 NTRK1 NTRK2 RET
5 cellular response to nerve growth factor stimulus GO:1990090 9.51 NTRK1 NTRK2
6 negative regulation of signal transduction GO:0009968 9.5 NTRK1 NTRK2 RET
7 innervation GO:0060384 9.43 NTRK1 RET
8 positive regulation of neuron projection development GO:0010976 9.43 NTRK1 NTRK2 RET
9 neurotrophin TRK receptor signaling pathway GO:0048011 9.4 NTRK1 NTRK2
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 NTRK1 NTRK2 RET
11 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
12 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.54 NTRK1 NTRK2 RET
2 protein tyrosine kinase activity GO:0004713 9.5 NTRK1 NTRK2 RET
3 kinase binding GO:0019900 9.43 GFAP MYCN NTRK1
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 NTRK1 NTRK2 RET
5 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
6 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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