MCID: GNG002
MIFTS: 54

Ganglioneuroma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ganglioneuroma

MalaCards integrated aliases for Ganglioneuroma:

Name: Ganglioneuroma 12 60 30 56 15 17 74

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4817
MeSH 45 D005729
NCIt 51 C42065 C6934
ICD10 via Orphanet 35 D36.1
UMLS via Orphanet 75 C0017075
Orphanet 60 ORPHA251992

Summaries for Ganglioneuroma

Disease Ontology : 12 An autonomic nervous system benign neoplasm that is characterized by the presence of mature ganglion cells and a mature Schwannian stroma and arises from the sympathetic trunk in the mediastinum.

MalaCards based summary : Ganglioneuroma is related to cutaneous ganglioneuroma and neuroblastoma, and has symptoms including seizures An important gene associated with Ganglioneuroma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Tyrosine Kinases / Adaptors. The drugs Dabrafenib and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, colon and bone, and related phenotypes are ganglioneuroma and colorectal polyposis

Wikipedia : 77 Ganglioneuroma is a rare and benign tumor of the autonomic nerve fibers arising from neural crest... more...

Related Diseases for Ganglioneuroma

Diseases related to Ganglioneuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 cutaneous ganglioneuroma 33.6 ENO2 NCAM1 SYP
2 neuroblastoma 31.9 ENO2 MYCN NTRK1 NTRK2
3 cystic teratoma 29.9 ENO2 GFAP SYP
4 teratoma 29.9 ENO2 GFAP SYP
5 paraganglioma 29.9 CHGA ENO2 RET SYP
6 ependymoma 29.8 ENO2 GFAP SYP
7 ganglioneuroblastoma 29.4 ENO2 GALP MYCN NTRK1 NTRK2 SYP
8 malignant pheochromocytoma 29.4 CHGA ENO2 SYP
9 pheochromocytoma 29.1 CHGA ENO2 NCAM1 NTRK1 RET SYP
10 thyroid carcinoma, familial medullary 28.9 CHGA ENO2 NTRK1 RET
11 olfactory neuroblastoma 28.8 CHGA ENO2 NTRK1 NTRK2 SYP
12 gangliocytoma 11.7
13 multiple endocrine neoplasia, type iib 11.5
14 central hypoventilation syndrome, congenital 11.5
15 multiple endocrine neoplasia, type iia 11.4
16 appendix adenocarcinoma 11.1
17 bone benign neoplasm 10.4 ENO2 SYP
18 connective tissue benign neoplasm 10.4 ENO2 SYP
19 mixed cell type cancer 10.4 ENO2 SYP
20 glomus tumor 10.4 ENO2 SYP
21 mucinous ovarian cystadenoma 10.4 ENO2 SYP
22 optic nerve neoplasm 10.4 ENO2 SYP
23 rhabdoid cancer 10.4 ENO2 SYP
24 intraocular retinoblastoma 10.4 ENO2 SYP
25 pineal parenchymal tumor of intermediate differentiation 10.4 ENO2 SYP
26 basaloid squamous cell carcinoma 10.4 ENO2 SYP
27 meningeal melanomatosis 10.4 ENO2 SYP
28 desmoplastic small round cell tumor 10.4 ENO2 SYP
29 extraskeletal ewing sarcoma 10.4 ENO2 SYP
30 papilloma of choroid plexus 10.3 GFAP SYP
31 obstructive hydrocephalus 10.3 GFAP SYP
32 pineoblastoma 10.3 GFAP SYP
33 childhood oligodendroglioma 10.3 GFAP SYP
34 cerebellopontine angle tumor 10.3 GFAP SYP
35 medulloepithelioma 10.3 GFAP SYP
36 fetal alcohol syndrome 10.3 GFAP VIP
37 anaplastic ependymoma 10.3 GFAP SYP
38 angiocentric glioma 10.3 GFAP SYP
39 neurofibromatosis, type i 10.3
40 sweat gland disease 10.3 GFAP NTRK1
41 ectopic cushing syndrome 10.3 RET SYP
42 spermatocele 10.3 NCAM1 SYP
43 neurofibromatosis, type iv, of riccardi 10.3
44 carotid body cancer 10.3 ENO2 SYP
45 malignant sertoli cell tumor 10.3 ENO2 SYP
46 scoliosis 10.3
47 traumatic brain injury 10.3 ENO2 GFAP
48 granular cell tumor 10.3 ENO2 GFAP
49 dysgerminoma of ovary 10.3 ENO2 GFAP
50 juvenile pilocytic astrocytoma 10.3 ENO2 GFAP

Graphical network of the top 20 diseases related to Ganglioneuroma:



Diseases related to Ganglioneuroma

Symptoms & Phenotypes for Ganglioneuroma

Human phenotypes related to Ganglioneuroma:

60 33 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ganglioneuroma 60 33 obligate (100%) Obligate (100%) HP:0003005
2 colorectal polyposis 60 33 frequent (33%) Frequent (79-30%) HP:0200063
3 abnormality of the mediastinum 60 33 frequent (33%) Frequent (79-30%) HP:0045026
4 multiple intestinal neurofibromatosis 60 33 frequent (33%) Frequent (79-30%) HP:0005220
5 hypertension 60 33 occasional (7.5%) Occasional (29-5%) HP:0000822
6 episodic abdominal pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0002574
7 hamartomatous polyposis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004390
8 functional intestinal obstruction 60 33 occasional (7.5%) Occasional (29-5%) HP:0005249
9 neoplasm of the adrenal gland 60 33 occasional (7.5%) Occasional (29-5%) HP:0100631
10 gastrointestinal hemorrhage 60 33 very rare (1%) Very rare (<4-1%) HP:0002239
11 central hypoventilation 60 33 very rare (1%) Very rare (<4-1%) HP:0007110
12 abnormal bone structure 60 33 very rare (1%) Very rare (<4-1%) HP:0003330
13 abnormality of the orbital region 60 33 very rare (1%) Very rare (<4-1%) HP:0000315
14 abnormality of the prostate 60 33 very rare (1%) Very rare (<4-1%) HP:0008775
15 abnormality of the adrenal glands 60 Frequent (79-30%)
16 abnormality of the rectum 60 Very rare (<4-1%)

UMLS symptoms related to Ganglioneuroma:


seizures

GenomeRNAi Phenotypes related to Ganglioneuroma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell viability after pRB stimulation GR00230-A-1 8.8 NTRK1 NTRK2 RET

MGI Mouse Phenotypes related to Ganglioneuroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ENO2 GALP GFAP MYCN NCAM1 NTRK1
2 growth/size/body region MP:0005378 9.86 CHGA ENO2 GALP GFAP MYCN NTRK1
3 nervous system MP:0003631 9.81 CHGA ENO2 GFAP MYCN NCAM1 NTRK1
4 normal MP:0002873 9.5 GFAP MYCN NTRK1 NTRK2 RET SYP
5 vision/eye MP:0005391 9.1 GFAP MYCN NCAM1 NTRK1 NTRK2 VIP

Drugs & Therapeutics for Ganglioneuroma

Drugs for Ganglioneuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
2
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
3
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
4
Trametinib Approved Phase 2 871700-17-3 11707110
5 Protein Kinase Inhibitors Phase 2
6 Antimitotic Agents Phase 2
7 Antineoplastic Agents, Phytogenic Phase 2
8
Irinotecan Approved, Investigational Phase 1 100286-90-6, 97682-44-5 60838
9
Bevacizumab Approved, Investigational Phase 1 216974-75-3
10 topoisomerase I inhibitors Phase 1
11 Topoisomerase Inhibitors Phase 1
12 Antineoplastic Agents, Immunological Phase 1
13 Angiogenesis Inhibitors Phase 1
14 Angiogenesis Modulating Agents Phase 1
15
Octreotide Approved, Investigational 83150-76-9 6400441 383414
16 Edotreotide
17 Fluorodeoxyglucose F18
18 Antineoplastic Agents, Hormonal
19 Gastrointestinal Agents
20 Radiopharmaceuticals

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib;Carboplatin with vincristine
2 Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed NCT01999270 Phase 1 Irinotecan;Bevacizumab
3 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Unknown status NCT02559804
4 DOTATOC PET/CT for Imaging NET Patients Recruiting NCT03583528
5 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroma

Genetic Tests for Ganglioneuroma

Genetic tests related to Ganglioneuroma:

# Genetic test Affiliating Genes
1 Ganglioneuroma 30

Anatomical Context for Ganglioneuroma

MalaCards organs/tissues related to Ganglioneuroma:

42
Adrenal Gland, Colon, Bone, Prostate, Skin, Spinal Cord, Thyroid

Publications for Ganglioneuroma

Articles related to Ganglioneuroma:

(show top 50) (show all 658)
# Title Authors Year
1
Laparoscopic Extirpation of Adrenal Gland Ganglioneuroma Incidentally Diagnosed During Evaluation for Patchy Alopecia Areata in an Adolescent Boy. ( 30897574 )
2019
2
Cutaneous ganglioneuroma: A case report and discussion of the literature. ( 30632184 )
2019
3
Laparoscopic adrenalectomy for ganglioneuroma presenting as an adrenal incidentaloma. ( 30618428 )
2019
4
Parapharyngeal Ganglioneuroma Detected by 18F-FDG PET/CT in a Patient With Hodgkin Lymphoma. ( 30672755 )
2019
5
Retroperitoneoscopic resection of a T11-L2 right-sided ganglioneuroma. ( 30879753 )
2019
6
Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents. ( 29369484 )
2018
7
Left adrenal ganglioneuroma: Report of a new case. ( 29631229 )
2018
8
Intraoperative Nerve Monitoring in Robotic-Assisted Resection Of Presacral Ganglioneuroma: Operative Technique. ( 29554323 )
2018
9
Cervical ganglioneuroma: clinical and radiological features of a rare tumour. ( 29326343 )
2018
10
Massive thoracic ganglioneuroma with significant mass effect on left hemithorax. ( 29437731 )
2018
11
Surgical approach to adrenal ganglioneuroma: Case report and literature review. ( 29974732 )
2018
12
Giant Thoracolumbar Dumbbell Ganglioneuroma. ( 29698954 )
2018
13
A rare cause of chronic ataxia in childhood: ganglioneuroma. ( 29532434 )
2018
14
Primary cutaneous ganglioneuroma: anatomico-clinical study of 4 cases with focus on Merkel cells. ( 29569258 )
2018
15
Adrenal collision tumor (parachordoma and ganglioneuroma): A case report. ( 29844903 )
2018
16
Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population. ( 29383425 )
2018
17
Simultaneous Presentation of Wilms' Tumor and Contralateral Ganglioneuroma in a Child: Case Report and Literature Review. ( 29334535 )
2018
18
Intradural ganglioneuroma mimicking lumbar disc herniation. Case Report. ( 29886296 )
2018
19
Lingual ganglioneuroma in a dog. ( 29367496 )
2018
20
Magnetic resonance neurography in the diagnosis of a retroperitoneal ganglioneuroma: Case report and literature review. ( 29904477 )
2018
21
Extensive spinal extradural ganglioneuroma of the lumbar spine: mimicking lymphoma. ( 29594468 )
2018
22
Artery first approach for resecting ganglioneuroma encasing superior mesenteric artery. ( 30093776 )
2018
23
Erratum: Adrenal collision tumor (parachordoma and ganglioneuroma): A case report. ( 30101030 )
2018
24
Rare adrenal ganglioneuroma encasing the inferior vena cava. ( 30117649 )
2018
25
Paediatric parapharyngeal ganglioneuroma. ( 30131403 )
2018
26
Retroperitoneal ganglioneuroma combined with scoliosis: A case report and literature review. ( 30212980 )
2018
27
An unusual cause of chronic back pain: retroperitoneal ganglioneuroma. ( 30290734 )
2018
28
Approach to a Posterior Cervico-mediastinal Ganglioneuroma. ( 30365962 )
2018
29
Laparoscopic Excision of an Adrenal Ganglioneuroma Presented as an Incindentaloma of the Retro Peritoneum. ( 30622759 )
2018
30
Cervical Ganglioneuroma in Pediatric Age: A Case Report. ( 30701121 )
2018
31
Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer. ( 28882936 )
2017
32
Ganglioneuroma of the Neck: A case report. ( 29148641 )
2017
33
Adrenal ganglioneuroma: The Padua Endocrine Surgery Unit experience. ( 28506406 )
2017
34
Giant Ganglioneuroma of Thoracic Spine: A Case Report and Review of Literature. ( 28490166 )
2017
35
Ganglioneuroma of the External Auditory Canal and Middle Ear. ( 28875046 )
2017
36
A Case Report of Giant Adrenal Ganglioneuroma. ( 28443238 )
2017
37
Composite paraganglioma-ganglioneuroma concomitant with adrenal metastasis of medullary thyroid carcinoma in a patient with multiple endocrine neoplasia type 2B: A case report. ( 27704704 )
2017
38
Robotic assisted laparoscopic excision of a retroperitoneal Ganglioneuroma. ( 28537695 )
2017
39
Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. ( 28608056 )
2017
40
Bilateral pheochromocytoma with ganglioneuroma component associated with multiple neuroendocrine neoplasia type 2A: a case report. ( 28760150 )
2017
41
Harlequin Syndrome Following Resection of Mediastinal Ganglioneuroma. ( 28382275 )
2017
42
Case report: Robot-assisted laparoscopic excision of giant ganglioneuroma of the adrenal gland. ( 28748502 )
2017
43
Colonic Ganglioneuroma: A Rare Finding during Colorectal Cancer Screening. ( 29033760 )
2017
44
Retroperitoneal Ganglioneuroma Mimicking a Kidney Tumor. Case Report. ( 28607627 )
2017
45
Every polyp is not an adenoma: Ganglioneuroma of the colon. ( 29198570 )
2017
46
Synchronous Ganglioneuroma and Schwannoma Mistaken for Carotid Body Tumor. ( 29147595 )
2017
47
Uveal Ganglioneuroma due to Germline PTEN Mutation (Cowden Syndrome) Presenting as Unilateral Infantile Glaucoma. ( 28868283 )
2017
48
Adrenal ganglioneuroma: What you need to know. ( 29085827 )
2017
49
Ganglioneuroma of the Sacrum. ( 29017308 )
2017
50
Chylothorax after mediastinal ganglioneuroma resection treated with fibrin sealant patch: a case report. ( 29221335 )
2017

Variations for Ganglioneuroma

Expression for Ganglioneuroma

Search GEO for disease gene expression data for Ganglioneuroma.

Pathways for Ganglioneuroma

GO Terms for Ganglioneuroma

Cellular components related to Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 NTRK1 NTRK2 RET

Biological processes related to Ganglioneuroma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.65 NCAM1 NTRK1 RET
2 peptidyl-tyrosine phosphorylation GO:0018108 9.61 NTRK1 NTRK2 RET
3 positive regulation of MAPK cascade GO:0043410 9.5 NTRK1 NTRK2 RET
4 cellular response to nerve growth factor stimulus GO:1990090 9.49 NTRK1 NTRK2
5 negative regulation of apoptotic process GO:0043066 9.46 NTRK1 VIP
6 positive regulation of neuron projection development GO:0010976 9.43 NTRK1 NTRK2 RET
7 innervation GO:0060384 9.4 NTRK1 RET
8 neurotrophin TRK receptor signaling pathway GO:0048011 9.37 NTRK1 NTRK2
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 NTRK1 NTRK2 RET
10 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
11 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.5 NTRK1 NTRK2 RET
2 kinase binding GO:0019900 9.43 GFAP MYCN NTRK1
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 NTRK1 NTRK2 RET
4 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
5 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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