MCID: GNG002
MIFTS: 53

Ganglioneuroma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ganglioneuroma

MalaCards integrated aliases for Ganglioneuroma:

Name: Ganglioneuroma 12 60 30 56 15 17 74

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4817
MeSH 45 D005729
NCIt 51 C42065 C6934
ICD10 via Orphanet 35 D36.1
UMLS via Orphanet 75 C0017075
Orphanet 60 ORPHA251992

Summaries for Ganglioneuroma

Disease Ontology : 12 An autonomic nervous system benign neoplasm that is characterized by the presence of mature ganglion cells and a mature Schwannian stroma and arises from the sympathetic trunk in the mediastinum.

MalaCards based summary : Ganglioneuroma is related to cutaneous ganglioneuroma and cerebellopontine angle tumor, and has symptoms including seizures An important gene associated with Ganglioneuroma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Tyrosine Kinases / Adaptors. The drugs Carboplatin and Trametinib have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, lung and bone, and related phenotypes are ganglioneuroma and colorectal polyposis

Wikipedia : 77 Ganglioneuroma is a rare and benign tumor of the autonomic nerve fibers arising from neural crest... more...

Related Diseases for Ganglioneuroma

Diseases related to Ganglioneuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)
# Related Disease Score Top Affiliating Genes
1 cutaneous ganglioneuroma 33.6 ENO2 NCAM1 SYP
2 cerebellopontine angle tumor 30.2 GFAP SYP
3 cystic teratoma 29.9 ENO2 GFAP SYP
4 teratoma 29.9 ENO2 GFAP SYP
5 paraganglioma 29.9 CHGA ENO2 RET SYP
6 ependymoma 29.8 ENO2 GFAP SYP
7 benign ependymoma 29.7 ENO2 GFAP SYP
8 ganglioneuroblastoma 29.4 ENO2 GALP MYCN NTRK1 NTRK2 SYP
9 malignant pheochromocytoma 29.4 CHGA ENO2 SYP
10 pheochromocytoma 29.1 CHGA ENO2 NCAM1 NTRK1 RET SYP
11 thyroid carcinoma, familial medullary 28.9 CHGA ENO2 NTRK1 RET
12 olfactory neuroblastoma 28.8 CHGA ENO2 NTRK1 NTRK2 SYP
13 gangliocytoma 11.8
14 multiple endocrine neoplasia, type iib 11.6
15 central hypoventilation syndrome, congenital 11.6
16 neuroblastoma 1 11.4
17 multiple endocrine neoplasia, type iia 11.4
18 appendix adenocarcinoma 11.1
19 adrenal gland pheochromocytoma 10.4
20 neurofibromatosis, type iv, of riccardi 10.4
21 bone benign neoplasm 10.4 ENO2 SYP
22 connective tissue benign neoplasm 10.4 ENO2 SYP
23 mixed cell type cancer 10.4 ENO2 SYP
24 glomus tumor 10.4 ENO2 SYP
25 mucinous ovarian cystadenoma 10.4 ENO2 SYP
26 optic nerve neoplasm 10.4 ENO2 SYP
27 rhabdoid cancer 10.4 ENO2 SYP
28 intraocular retinoblastoma 10.4 ENO2 SYP
29 pineal parenchymal tumor of intermediate differentiation 10.4 ENO2 SYP
30 basaloid squamous cell carcinoma 10.4 ENO2 SYP
31 meningeal melanomatosis 10.4 ENO2 SYP
32 desmoplastic small round cell tumor 10.4 ENO2 SYP
33 extraskeletal ewing sarcoma 10.4 ENO2 SYP
34 papilloma of choroid plexus 10.4 GFAP SYP
35 obstructive hydrocephalus 10.3 GFAP SYP
36 pineoblastoma 10.3 GFAP SYP
37 childhood oligodendroglioma 10.3 GFAP SYP
38 medulloepithelioma 10.3 GFAP SYP
39 fetal alcohol syndrome 10.3 GFAP VIP
40 anaplastic ependymoma 10.3 GFAP SYP
41 angiocentric glioma 10.3 GFAP SYP
42 neurofibromatosis, type i 10.3
43 sweat gland disease 10.3 GFAP NTRK1
44 scoliosis 10.3
45 ectopic cushing syndrome 10.3 RET SYP
46 spermatocele 10.3 NCAM1 SYP
47 carotid body cancer 10.3 ENO2 SYP
48 malignant sertoli cell tumor 10.3 ENO2 SYP
49 traumatic brain injury 10.3 ENO2 GFAP
50 granular cell tumor 10.3 ENO2 GFAP

Graphical network of the top 20 diseases related to Ganglioneuroma:



Diseases related to Ganglioneuroma

Symptoms & Phenotypes for Ganglioneuroma

Human phenotypes related to Ganglioneuroma:

60 33 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ganglioneuroma 60 33 obligate (100%) Obligate (100%) HP:0003005
2 colorectal polyposis 60 33 frequent (33%) Frequent (79-30%) HP:0200063
3 abnormality of the mediastinum 60 33 frequent (33%) Frequent (79-30%) HP:0045026
4 multiple intestinal neurofibromatosis 60 33 frequent (33%) Frequent (79-30%) HP:0005220
5 hypertension 60 33 occasional (7.5%) Occasional (29-5%) HP:0000822
6 episodic abdominal pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0002574
7 hamartomatous polyposis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004390
8 functional intestinal obstruction 60 33 occasional (7.5%) Occasional (29-5%) HP:0005249
9 neoplasm of the adrenal gland 60 33 occasional (7.5%) Occasional (29-5%) HP:0100631
10 gastrointestinal hemorrhage 60 33 very rare (1%) Very rare (<4-1%) HP:0002239
11 central hypoventilation 60 33 very rare (1%) Very rare (<4-1%) HP:0007110
12 abnormal bone structure 60 33 very rare (1%) Very rare (<4-1%) HP:0003330
13 abnormality of the orbital region 60 33 very rare (1%) Very rare (<4-1%) HP:0000315
14 abnormality of the prostate 60 33 very rare (1%) Very rare (<4-1%) HP:0008775
15 abnormality of the adrenal glands 60 Frequent (79-30%)
16 abnormality of the rectum 60 Very rare (<4-1%)

UMLS symptoms related to Ganglioneuroma:


seizures

GenomeRNAi Phenotypes related to Ganglioneuroma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell viability after pRB stimulation GR00230-A-1 8.8 NTRK1 NTRK2 RET

MGI Mouse Phenotypes related to Ganglioneuroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ENO2 GALP GFAP MYCN NCAM1 NTRK1
2 growth/size/body region MP:0005378 9.86 CHGA ENO2 GALP GFAP MYCN NTRK1
3 nervous system MP:0003631 9.81 CHGA ENO2 GFAP MYCN NCAM1 NTRK1
4 normal MP:0002873 9.5 GFAP MYCN NTRK1 NTRK2 RET SYP
5 vision/eye MP:0005391 9.1 GFAP MYCN NCAM1 NTRK1 NTRK2 VIP

Drugs & Therapeutics for Ganglioneuroma

Drugs for Ganglioneuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
2
Trametinib Approved Phase 2 871700-17-3 11707110
3
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
4
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
5 Protein Kinase Inhibitors Phase 2
6 Antineoplastic Agents, Phytogenic Phase 2
7 Antimitotic Agents Phase 2
8
Bevacizumab Approved, Investigational Phase 1 216974-75-3
9
Irinotecan Approved, Investigational Phase 1 100286-90-6, 97682-44-5 60838
10 Topoisomerase Inhibitors Phase 1
11 Angiogenesis Inhibitors Phase 1
12 topoisomerase I inhibitors Phase 1
13 Angiogenesis Modulating Agents Phase 1
14 Antineoplastic Agents, Immunological Phase 1
15
Octreotide Approved, Investigational 83150-76-9 6400441 383414
16 Radiopharmaceuticals
17 Gastrointestinal Agents
18 Antineoplastic Agents, Hormonal
19 Fluorodeoxyglucose F18
20 Edotreotide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib;Carboplatin with vincristine
2 Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed NCT01999270 Phase 1 Irinotecan;Bevacizumab
3 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Unknown status NCT02559804
4 DOTATOC PET/CT for Imaging NET Patients Recruiting NCT03583528
5 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroma

Genetic Tests for Ganglioneuroma

Genetic tests related to Ganglioneuroma:

# Genetic test Affiliating Genes
1 Ganglioneuroma 30

Anatomical Context for Ganglioneuroma

MalaCards organs/tissues related to Ganglioneuroma:

42
Adrenal Gland, Lung, Bone, Colon, Thyroid, Ovary, Prostate

Publications for Ganglioneuroma

Articles related to Ganglioneuroma:

(show top 50) (show all 662)
# Title Authors Year
1
Laparoscopic Extirpation of Adrenal Gland Ganglioneuroma Incidentally Diagnosed During Evaluation for Patchy Alopecia Areata in an Adolescent Boy. ( 30897574 )
2019
2
Cutaneous Ganglioneuroma: A Case Report and Discussion of the Literature. ( 30632184 )
2019
3
Intraoperative Nerve Monitoring in Robotic-Assisted Resection Of Presacral Ganglioneuroma: Operative Technique. ( 29554323 )
2019
4
Approach to a Posterior Cervicomediastinal Ganglioneuroma. ( 30365962 )
2019
5
Laparoscopic adrenalectomy for ganglioneuroma presenting as an adrenal incidentaloma. ( 30618428 )
2019
6
Parapharyngeal Ganglioneuroma Detected by 18F-FDG PET/CT in a Patient With Hodgkin Lymphoma. ( 30672755 )
2019
7
Retroperitoneoscopic resection of a T11-L2 right-sided ganglioneuroma. ( 30879753 )
2019
8
Cervical ganglioneuroma: A case report and review of the literature. ( 30985715 )
2019
9
Pathological thoracic spine scoliosis due to ganglioneuroma. ( 31033504 )
2019
10
Laparoscopic celiac plexus ganglioneuroma resection: A video case report. ( 31057703 )
2019
11
Lumbar ganglioneuroma from the paravertebral body presenting in continuity between intra- and extradural spaces: a case report. ( 31102769 )
2019
12
Every polyp is not an adenoma: Ganglioneuroma of the colon. ( 29198570 )
2018
13
Primary cutaneous ganglioneuroma: anatomico-clinical study of 4 cases with focus on Merkel cells. ( 29569258 )
2018
14
De Novo Tumors of Teratoma: Ganglioneuroma Arising From a Mature Cystic Teratoma of the Ovary. ( 28700440 )
2018
15
Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents. ( 29369484 )
2018
16
What Do We Need to Know About Colonic Polypoid Ganglioneuroma? A Case Report and A Comprehensive Review. ( 27888390 )
2018
17
Case report: Robot-assisted laparoscopic excision of giant ganglioneuroma of the adrenal gland. ( 28748502 )
2018
18
Cervical ganglioneuroma: clinical and radiological features of a rare tumour. ( 29326343 )
2018
19
Simultaneous Presentation of Wilms' Tumor and Contralateral Ganglioneuroma in a Child: Case Report and Literature Review. ( 29334535 )
2018
20
Lingual ganglioneuroma in a dog. ( 29367496 )
2018
21
Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population. ( 29383425 )
2018
22
Massive thoracic ganglioneuroma with significant mass effect on left hemithorax. ( 29437731 )
2018
23
A rare cause of chronic ataxia in childhood: ganglioneuroma. ( 29532434 )
2018
24
Extensive spinal extradural ganglioneuroma of the lumbar spine: mimicking lymphoma. ( 29594468 )
2018
25
Left adrenal ganglioneuroma: Report of a new case. ( 29631229 )
2018
26
Giant Thoracolumbar Dumbbell Ganglioneuroma. ( 29698954 )
2018
27
Adrenal collision tumor (parachordoma and ganglioneuroma): A case report. ( 29844903 )
2018
28
Intradural Ganglioneuroma Mimicking Lumbar Disc Herniation: Case Report. ( 29886296 )
2018
29
Magnetic resonance neurography in the diagnosis of a retroperitoneal ganglioneuroma: Case report and literature review. ( 29904477 )
2018
30
Surgical approach to adrenal ganglioneuroma: Case report and literature review. ( 29974732 )
2018
31
Artery first approach for resecting ganglioneuroma encasing superior mesenteric artery. ( 30093776 )
2018
32
Erratum: Adrenal collision tumor (parachordoma and ganglioneuroma): A case report. ( 30101030 )
2018
33
Rare adrenal ganglioneuroma encasing the inferior vena cava. ( 30117649 )
2018
34
Paediatric parapharyngeal ganglioneuroma. ( 30131403 )
2018
35
Retroperitoneal ganglioneuroma combined with scoliosis: A case report and literature review. ( 30212980 )
2018
36
An unusual cause of chronic back pain: retroperitoneal ganglioneuroma. ( 30290734 )
2018
37
Laparoscopic Excision of an Adrenal Ganglioneuroma Presented as an Incindentaloma of the Retro Peritoneum. ( 30622759 )
2018
38
Cervical Ganglioneuroma in Pediatric Age: A Case Report. ( 30701121 )
2018
39
Images in Endocrine Pathology: Unique Composite Adrenal Adenomatoid Tumor, Ganglioneuroma, Myelolipoma, and Cortical Nodular Hyperplasia. ( 28382483 )
2017
40
Trigeminal Ganglioneuroma: A Rare Case of Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumor. ( 28043883 )
2017
41
Uveal Ganglioneuroma due to Germline PTEN Mutation (Cowden Syndrome) Presenting as Unilateral Infantile Glaucoma. ( 28868283 )
2017
42
Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. ( 28608056 )
2017
43
Adrenal ganglioneuroma in a pregnant woman. ( 27364185 )
2017
44
Composite paraganglioma-ganglioneuroma concomitant with adrenal metastasis of medullary thyroid carcinoma in a patient with multiple endocrine neoplasia type 2B: A case report. ( 27704704 )
2017
45
Ganglioneuroma with Disseminated Bone Lesions. ( 28221728 )
2017
46
Synchronous ganglioneuroma and schwannoma of the vagal inferior ganglion. ( 28291514 )
2017
47
Giant Ganglioneuroma in a 5-Year Child. ( 28302232 )
2017
48
Harlequin Syndrome Following Resection of Mediastinal Ganglioneuroma. ( 28382275 )
2017
49
A Case Report of Giant Adrenal Ganglioneuroma. ( 28443238 )
2017
50
Giant Ganglioneuroma of Thoracic Spine: A Case Report and Review of Literature. ( 28490166 )
2017

Variations for Ganglioneuroma

Expression for Ganglioneuroma

Search GEO for disease gene expression data for Ganglioneuroma.

Pathways for Ganglioneuroma

GO Terms for Ganglioneuroma

Cellular components related to Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 NTRK1 NTRK2 RET

Biological processes related to Ganglioneuroma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.65 NCAM1 NTRK1 RET
2 peptidyl-tyrosine phosphorylation GO:0018108 9.61 NTRK1 NTRK2 RET
3 positive regulation of MAPK cascade GO:0043410 9.5 NTRK1 NTRK2 RET
4 cellular response to nerve growth factor stimulus GO:1990090 9.49 NTRK1 NTRK2
5 negative regulation of apoptotic process GO:0043066 9.46 NTRK1 VIP
6 positive regulation of neuron projection development GO:0010976 9.43 NTRK1 NTRK2 RET
7 innervation GO:0060384 9.4 NTRK1 RET
8 neurotrophin TRK receptor signaling pathway GO:0048011 9.37 NTRK1 NTRK2
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 NTRK1 NTRK2 RET
10 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
11 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.5 NTRK1 NTRK2 RET
2 kinase binding GO:0019900 9.43 GFAP MYCN NTRK1
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 NTRK1 NTRK2 RET
4 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
5 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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