Aliases & Classifications for Gas Gangrene

MalaCards integrated aliases for Gas Gangrene:

Name: Gas Gangrene 38 12 55 44 15 73
Myonecrosis 12 73
Gas Bacillus Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9159
ICD10 33 A48.0
ICD9CM 35 040.0
MeSH 44 D005738

Summaries for Gas Gangrene

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary : Gas Gangrene, also known as myonecrosis, is related to toxic myocarditis and myocarditis, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Cardiac Progenitor Differentiation. The drugs Glyburide and Imidacloprid have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, liver and colon, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 toxic myocarditis 30.5 PIK3C2A TNNI3
2 myocarditis 28.7 DMD MB TNNI3
3 myositis 28.5 DMD MB PIK3C2A
4 anthrax disease 11.2
5 tick paralysis 10.7 PIK3C2A TNNI3
6 familial isolated restrictive cardiomyopathy 10.6 TNNI3 TNNT2
7 myocardial stunning 10.5 TNNI3 TNNT2
8 extrinsic cardiomyopathy 10.5 PIK3C2A TNNI3
9 chromosome xp21 deletion syndrome 10.3 DMD PIK3C2A
10 muscular dystrophy-dystroglycanopathy , type b, 6 10.3 DMD HSPG2
11 panophthalmitis 10.2
12 cardiomyopathy, dilated, 1d 10.1 DMD TNNT2
13 hepatitis 10.1
14 fasciitis 10.1
15 necrotizing fasciitis 10.1
16 virus associated hemophagocytic syndrome 10.1 MB PIK3C2A
17 interstitial myocarditis 10.1 MB PIK3C2A
18 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.0 MB PIK3C2A
19 burns 10.0
20 tetanus 10.0
21 adenocarcinoma 10.0
22 posterior myocardial infarction 10.0 MB PIK3C2A
23 myositis fibrosa 10.0 MB PIK3C2A
24 anuria 10.0 MB PIK3C2A
25 diabetes mellitus 10.0
26 cholecystitis 10.0
27 corneal dystrophy, subepithelial mucinous 10.0 MB TNNI3
28 neuroleptic malignant syndrome 10.0 MB PIK3C2A
29 plexopathy 10.0 MB PIK3C2A
30 compartment syndrome 9.9 MB PIK3C2A
31 leukemia 9.9
32 peritonitis 9.9
33 pericardium cancer 9.9 MB TNNI3
34 myotonia 9.9 DMD HSPG2
35 familial isolated dilated cardiomyopathy 9.9 DMD TNNI3 TNNT2
36 intrinsic cardiomyopathy 9.9 DMD TNNI3 TNNT2
37 dirofilariasis 9.9 MB TNNI3
38 acute mountain sickness 9.8 MB PIK3C2A
39 enterocolitis 9.8
40 liver cirrhosis 9.8
41 neutropenia 9.8
42 lymphoma 9.8
43 penicillin allergy 9.8
44 thrombosis 9.8
45 osteomyelitis 9.8
46 esophagitis 9.8
47 pancreatitis 9.8
48 emphysematous cholecystitis 9.8
49 atrial standstill 1 9.8 DMD TNNI3 TNNT2
50 pseudohyperkalemia, familial, 2, due to red cell leak 9.8 MB PIK3C2A

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to Gas Gangrene

Symptoms & Phenotypes for Gas Gangrene

Symptoms:

12
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

UMLS symptoms related to Gas Gangrene:


muscle cramp, myoclonus, torticollis

MGI Mouse Phenotypes related to Gas Gangrene:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 PIK3C2A PRF1 TNNI3 TNNT2 DMD HSPG2
2 growth/size/body region MP:0005378 9.97 CPE DMD HSPG2 MB NEU1 PIK3C2A
3 muscle MP:0005369 9.7 CPE DMD HSPG2 MB NEU1 TNNI3
4 liver/biliary system MP:0005370 9.65 CPE DMD HSPG2 NEU1 PRF1
5 nervous system MP:0003631 9.56 CPE DMD HSPG2 NEU1 PIK3C2A PRF1
6 respiratory system MP:0005388 9.02 MB NEU1 TNNI3 DMD HSPG2

Drugs & Therapeutics for Gas Gangrene

Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 2,Phase 1 10238-21-8 3488
2
Imidacloprid Vet_approved Phase 2,Phase 1 105827-78-9 86418
3 Hypoglycemic Agents Phase 2,Phase 1
4 Antibodies Phase 2
5 gamma-Globulins Phase 2
6 Immunoglobulin G Phase 2
7 Immunoglobulins Phase 2
8 Immunoglobulins, Intravenous Phase 2
9 Rho(D) Immune Globulin Phase 2
10
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
11
Protein C Approved

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals Unknown status NCT01794182 Phase 2 RP-1127 (Glyburide for Injection)
2 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
5 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
8 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
9 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Recruiting NCT03431402 Not Applicable Hyperbaric oxygen
10 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

Anatomical Context for Gas Gangrene

The Foundational Model of Anatomy Ontology organs/tissues related to Gas Gangrene:

19
Muscle Tissue

MalaCards organs/tissues related to Gas Gangrene:

41
Liver, Colon, Uterus, Pancreas, Heart, Brain, Bone

Publications for Gas Gangrene

Articles related to Gas Gangrene:

(show top 50) (show all 547)
# Title Authors Year
1
Gas Gangrene of Malignant Mixed Mullerian Tumor of Ovary Caused by Clostridium perfringens. ( 29685470 )
2018
2
Use of Viable Cryopreserved Umbilical Tissue for Soft Tissue Defects in Patients With Gas Gangrene: A Case Series. ( 29718818 )
2018
3
Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model. ( 29246581 )
2018
4
Gas gangrene of the eye: endogenous <em>Clostridium perfringens</em> endophthalmitis. ( 29385972 )
2018
5
Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat. ( 28936381 )
2017
6
Fatal liver gas gangrene after biliary surgery. ( 28783522 )
2017
7
A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens I+-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis. ( 28401477 )
2017
8
Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model. ( 28213749 )
2017
9
Non-clostridial gas gangrene in a patient with poorly controlled type 2 diabetes mellitus on hemodialysis. ( 28871383 )
2017
10
Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland. ( 28735323 )
2017
11
Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A. ( 28934314 )
2017
12
Spontaneous C.A septicum gas gangrene: A literature review. ( 28780428 )
2017
13
CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT). ( 27770534 )
2016
14
Massive gas gangrene secondary to occult colon carcinoma. ( 27257452 )
2016
15
A case of acute onset postoperative gas gangrene caused by Clostridium perfringens. ( 27488346 )
2016
16
An Uncommon Cause of Gas Gangrene. ( 27713042 )
2016
17
Blackish haematuria and gas gangrene. ( 27272762 )
2016
18
Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection. ( 27274183 )
2016
19
Radiological diagnosis of gas gangrene in a fetus at term. ( 27590386 )
2016
20
Iatrogenic non-clostridial gas gangrene - a case report. ( 26672772 )
2016
21
Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review. ( 27490157 )
2016
22
Vertebral osteomyelitis and epidural abscess caused by gas gangrene presenting with complete paraplegia: a case report. ( 25888739 )
2015
23
Interventions for treating gas gangrene. ( 26631369 )
2015
24
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. ( 26369267 )
2015
25
A case of freeze-dried gas gangrene antitoxin for the treatment of Clostridium perfringens sepsis. ( 25748160 )
2015
26
Retroperitoneal necrotizing fasciitis with gas gangrene, caused by perforated caecal diverticulitis. ( 25675887 )
2015
27
Clostridium Sacroiliitis (Gas Gangrene) Following Sacroiliac Joint Injection--Case Report and Review of the Literature. ( 26218953 )
2015
28
Necrotizing myonecrosis secondary to hematogenous spread of gas gangrene following colonic perforation. ( 25787163 )
2015
29
Hepatic gas gangrene. ( 25986279 )
2015
30
Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis. ( 26793397 )
2015
31
A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus). ( 26156080 )
2015
32
Gas Gangrene of the Diabetic Foot. ( 27159595 )
2015
33
Retraction: Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene. ( 26790486 )
2015
34
Improved vacuum sealing drainage in the treatment of gas gangrene: a case report. ( 26770624 )
2015
35
Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. ( 26223928 )
2015
36
Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression. ( 24878026 )
2014
37
Opioid analgesics stop the development of clostridial gas gangrene. ( 24550443 )
2014
38
Fatal massive infectious gas gangrene in a liver transplant recipient. ( 24415557 )
2014
39
Images in clinical medicine: Gas gangrene of a prosthetic hip. ( 25390742 )
2014
40
Gas gangrene presenting with back pain. ( 24811103 )
2014
41
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review. ( 25298910 )
2014
42
Analysis of genetic similarities between Clostridium perfringens isolates isolated from patients with gas gangrene and from hospital environment conducted with the use of the PFGE method. ( 24791817 )
2014
43
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. ( 24590337 )
2014
44
Fatal retroperitoneal gas gangrene complicating colonoscopic polypectomy without bowel perforation in a healthy adult. ( 24676832 )
2014
45
Escherichia coli gas gangrene in an immunosuppressed diabetic man. ( 24842101 )
2014
46
Gas gangrene: need for aggressive management in delayed presentation. ( 24787142 )
2014
47
Gas gangrene in the diabetic foot: lessons learned from a salvaged limb. ( 24720142 )
2014
48
Comprehensive treatment for gas gangrene of the limbs in earthquakes. ( 24157141 )
2013
49
Clostridium septicum gas gangrene in the orbit: a case report. ( 23203898 )
2013
50
Gas gangrene in orthopaedic patients. ( 24288638 )
2013

Variations for Gas Gangrene

Expression for Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for Gas Gangrene

Pathways related to Gas Gangrene according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.57 DMD TNNI3 TNNT2
2 10.98 TNNI3 TNNT2
3 10.66 DMD TNNI3 TNNT2
4 10.23 DMD HSPG2

GO Terms for Gas Gangrene

Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.67 CPE NEU1 PIK3C2A PRF1
2 secretory granule GO:0030141 9.5 CPE DMD PLA2G2A
3 sarcomere GO:0030017 9.4 TNNI3 TNNT2
4 troponin complex GO:0005861 9.26 TNNI3 TNNT2
5 cardiac myofibril GO:0097512 9.16 TNNI3 TNNT2
6 myofibril GO:0030016 9.13 DMD TNNI3 TNNT2
7 cardiac Troponin complex GO:1990584 8.62 TNNI3 TNNT2

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.37 TNNI3 TNNT2
2 skeletal muscle contraction GO:0003009 9.32 TNNI3 TNNT2
3 regulation of muscle contraction GO:0006937 9.26 TNNI3 TNNT2
4 negative regulation of ATPase activity GO:0032780 9.16 TNNI3 TNNT2
5 cardiac muscle contraction GO:0060048 9.13 DMD TNNI3 TNNT2
6 muscle filament sliding GO:0030049 8.8 DMD TNNI3 TNNT2

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 HSPG2 PLA2G2A PRF1 TNNT2
2 troponin C binding GO:0030172 8.62 TNNI3 TNNT2

Sources for Gas Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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