MCID: GSG001
MIFTS: 45

Gas Gangrene

Categories: Infectious diseases, Muscle diseases

Aliases & Classifications for Gas Gangrene

MalaCards integrated aliases for Gas Gangrene:

Name: Gas Gangrene 38 12 55 44 15 73
Myonecrosis 12 73
Gas Bacillus Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9159
ICD10 33 A48.0
ICD9CM 35 040.0
MeSH 44 D005738
SNOMED-CT 68 80466000

Summaries for Gas Gangrene

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary : Gas Gangrene, also known as myonecrosis, is related to compartment syndrome and toxic myocarditis, and has symptoms including myoclonus, torticollis and muscle cramp. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways is Muscular Dystrophies and Dystrophin-Glycoprotein Complex. The drugs Glyburide and Imidacloprid have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and uterus, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 compartment syndrome 30.3 MB PIK3C2A
2 toxic myocarditis 30.0 PIK3C2A TNNI3
3 myoglobinuria 29.9 MB PIK3C2A
4 coronary artery anomaly 29.7 MB PIK3C2A TNNI3
5 myocarditis 29.7 DMD MB TNNI3
6 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 29.6 MB PIK3C2A
7 acute myocardial infarction 29.5 MB PIK3C2A TNNI3
8 myositis 29.4 DMD MB MYOD1 PIK3C2A
9 anthrax disease 11.3
10 tetanus 10.4
11 panophthalmitis 10.3
12 tick paralysis 10.2 PIK3C2A TNNI3
13 fasciitis 10.2
14 necrotizing fasciitis 10.2
15 pericardium disease 10.2 PIK3C2A TNNI3
16 glycogen storage disease iii 10.2 PIK3C2A TNNI3
17 extrinsic cardiomyopathy 10.1 PIK3C2A TNNI3
18 sickle cell anemia 10.1
19 chromosome xp21 deletion syndrome 10.1 DMD PIK3C2A
20 adenocarcinoma 10.1
21 muscular dystrophy-dystroglycanopathy , type b, 6 10.1 DMD HSPG2
22 muscular dystrophy, becker type 10.1 DMD PIK3C2A
23 burns 10.1
24 diabetes mellitus 10.1
25 leukemia 10.1
26 cholecystitis 10.1
27 coronary stenosis 10.1 PIK3C2A TNNI3
28 familial isolated dilated cardiomyopathy 10.1 DMD TNNI3
29 virus associated hemophagocytic syndrome 10.0 MB PIK3C2A
30 interstitial myocarditis 10.0 MB PIK3C2A
31 peritonitis 10.0
32 intrinsic cardiomyopathy 10.0 DMD TNNI3
33 posterior myocardial infarction 10.0 MB PIK3C2A
34 myositis fibrosa 10.0 MB PIK3C2A
35 anuria 10.0 MB PIK3C2A
36 corneal dystrophy, subepithelial mucinous 10.0 MB TNNI3
37 neuroleptic malignant syndrome 10.0 MB PIK3C2A
38 plexopathy 10.0 MB PIK3C2A
39 aspirin resistance 10.0
40 myocardial infarction 10.0
41 ischemia 10.0
42 pericardium cancer 10.0 MB TNNI3
43 pseudohyperkalemia, familial, 2, due to red cell leak 10.0 MB PIK3C2A
44 acute mountain sickness 10.0 MB PIK3C2A
45 breast rhabdomyosarcoma 10.0 MB MYOD1
46 malignant triton tumor 9.9 MB MYOD1
47 botryoid rhabdomyosarcoma 9.9 MB MYOD1
48 mesenchymoma 9.9 MB MYOD1
49 spindle cell rhabdomyosarcoma 9.9 MB MYOD1
50 pleomorphic rhabdomyosarcoma 9.9 MB MYOD1

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to Gas Gangrene

Symptoms & Phenotypes for Gas Gangrene

UMLS symptoms related to Gas Gangrene:


myoclonus, torticollis, muscle cramp

MGI Mouse Phenotypes related to Gas Gangrene:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 DMD HSPG2 MB MYOD1 NEU1 PIK3C2A
2 growth/size/body region MP:0005378 9.97 CPE DMD HSPG2 MB MYOD1 NEU1
3 homeostasis/metabolism MP:0005376 9.86 CPE DMD HSPG2 MB MYOD1 NEU1
4 liver/biliary system MP:0005370 9.55 CPE DMD HSPG2 NEU1 PRF1
5 muscle MP:0005369 9.5 CPE DMD HSPG2 MB MYOD1 NEU1
6 respiratory system MP:0005388 9.1 DMD HSPG2 MB MYOD1 NEU1 TNNI3

Drugs & Therapeutics for Gas Gangrene

Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 2,Phase 1 10238-21-8 3488
2
Imidacloprid Vet_approved Phase 2,Phase 1 105827-78-9 86418
3 Hypoglycemic Agents Phase 2,Phase 1
4 Immunoglobulins Phase 2
5 Rho(D) Immune Globulin Phase 2
6 gamma-Globulins Phase 2
7 Immunoglobulin G Phase 2
8 Immunoglobulins, Intravenous Phase 2
9 Antibodies Phase 2
10 Immunologic Factors Phase 2
11
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
12
Protein C Approved

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals Unknown status NCT01794182 Phase 2 RP-1127 (Glyburide for Injection)
2 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
5 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
8 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
9 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Recruiting NCT03431402 Not Applicable Hyperbaric oxygen
10 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

Anatomical Context for Gas Gangrene

MalaCards organs/tissues related to Gas Gangrene:

41
Liver, Colon, Uterus, Bone, Heart, Lung, Bone Marrow

Publications for Gas Gangrene

Articles related to Gas Gangrene:

(show top 50) (show all 1156)
# Title Authors Year
1
Gas Gangrene of Malignant Mixed Mullerian Tumor of Ovary Caused by Clostridium perfringens. ( 29685470 )
2018
2
Use of Viable Cryopreserved Umbilical Tissue for Soft Tissue Defects in Patients With Gas Gangrene: A Case Series. ( 29718818 )
2018
3
Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model. ( 29246581 )
2018
4
Clostridium septicum Myonecrosis Secondary to an Occult Small Bowel Adenocarcinoma. ( 30198050 )
2018
5
Extensive septic myonecrosis related to compartment syndrome: is the upper extremity salvage achievable in precarious setting? ( 29997082 )
2018
6
Gas gangrene of the eye: endogenous <em>Clostridium perfringens</em> endophthalmitis. ( 29385972 )
2018
7
Retroperitoneal necrotizing fasciitis with gas gangrene caused by urethral stricture. ( 29984183 )
2018
8
Successful treatment of hepatic gas gangrene by open drainage: A case report and review of the Japanese literature. ( 30005363 )
2018
9
Gas gangrene following implant removal after the union of a tibial plateau fracture: a case report. ( 30045706 )
2018
10
Gas gangrene in the deep spaces of the head and neck visualized on computed tomography images. ( 30484087 )
2018
11
Calcific myonecrosis mimicking soft tissue sarcoma: A case report. ( 29731908 )
2018
12
A challenging case of calcific myonecrosis of tibialis anterior and hallucis longus muscles with a chronic discharging wound. ( 29076298 )
2018
13
The Role of FDG PET in Diabetic Myonecrosis: A Rare and Underrecognized Complication of Diabetes. ( 29232246 )
2018
14
Tendon Transfers to Restore Ankle Dorsiflexion After Anterior Compartment Myonecrosis: A Case Report. ( 29369060 )
2018
15
Atraumatic Clostridial Myonecrosis in an Immunocompromised Host. ( 29534840 )
2018
16
Concurrent Host-Pathogen Transcriptional Responses in a Clostridium perfringens Murine Myonecrosis Infection. ( 29588405 )
2018
17
Calcific myonecrosis: diagnostic dilemma. ( 29658341 )
2018
18
Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms? ( 29723952 )
2018
19
Biopsy-Proven Myonecrosis in the Right Forearm of a Type 2 Diabetic Woman. ( 29742536 )
2018
20
Don't Move a Muscle: A Case of Diabetic Myonecrosis. ( 30055124 )
2018
21
Inactivation of Venom PLA₂ Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation. ( 30065214 )
2018
22
A Wolf in Sheep's Clothing: An Unusual Presentation of Diabetic Myonecrosis. ( 30134275 )
2018
23
A Wolf in Sheep's Clothing: An Unusual Presentation of Diabetic Myonecrosis. ( 30134280 )
2018
24
Diabetic Myonecrosis: A Diagnostic and Treatment Challenge in Longstanding Diabetes. ( 30159176 )
2018
25
Management of calcific myonecrosis with a sinus tract: A case report. ( 30235769 )
2018
26
Recurrent diabetic myonecrosis -an under-diagnosed cause of acute painful swollen limb in long standing diabetics. ( 30302243 )
2018
27
Calcific myonecrosis: imaging and radiographic findings. ( 30418826 )
2018
28
Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat. ( 28936381 )
2017
29
Fatal liver gas gangrene after biliary surgery. ( 28783522 )
2017
30
A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens I+-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis. ( 28401477 )
2017
31
Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model. ( 28213749 )
2017
32
Non-clostridial gas gangrene in a patient with poorly controlled type 2 diabetes mellitus on hemodialysis. ( 28871383 )
2017
33
Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland. ( 28735323 )
2017
34
Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A. ( 28934314 )
2017
35
Spontaneous C. septicum gas gangrene: A literature review. ( 28780428 )
2017
36
Myonecrosis in Sickle Cell Anemia: Case Study. ( 28133359 )
2017
37
Clinics in diagnostic imaging (179). Severe rhabdomyolysis complicated by myonecrosis. ( 28848989 )
2017
38
Calcific myonecrosis arising in the bilateral deltoid muscles: A case report. ( 26806333 )
2017
39
Acute Lumbar Paraspinal Myonecrosis in Football Players with Sickle Cell Trait: A Case Series. ( 27875493 )
2017
40
Diabetic Myonecrosis: A Rare Complication of Diabetes Mellitus Mimicking Deep Vein Thrombosis. ( 28074044 )
2017
41
Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine. ( 28161653 )
2017
42
Antiviral Activity of Ctn[15-34], A Cathelicidin-Derived Eicosapeptide, Against Infectious Myonecrosis Virus in Litopenaeus vannamei Primary Hemocyte Cultures. ( 28210987 )
2017
43
Correlation of Systemic Inflammatory Status and Cardiac Myonecrosis in Patients Undergoing Percutaneoues Coronary Intervention. ( 28260767 )
2017
44
Hsp70 gene polymorphisms in farmed marine shrimp Litopenaeus vannamei populations exposed to white spot disease and infectious myonecrosis. ( 28481405 )
2017
45
Correlations between High Platelet Reactivity, Extent of Coronary Artery Disease, and Periprocedural Myonecrosis in Patients with Acute Coronary Syndrome. ( 28584794 )
2017
46
Studies on the occurrence of infectious myonecrosis virus in pond-reared Litopenaeus vannamei (Boone, 1931) in India. ( 28631825 )
2017
47
Fatal Clostridium septicum multifocal myonecrosis in a previously healthy 25-year-old man: Role of NSAIDs? ( 28705640 )
2017
48
Thoracolumbar Paraspinal Myonecrosis after Aortic Dissection. ( 29201858 )
2017
49
Neutralization of Naja naja venom induced lethality, edema and myonecrosis by ethanolic root extract of Coix lacryma-jobi. ( 29234602 )
2017
50
Aseptic myonecrosis following intramuscular benzathine penicllin G injection: a novel syndrome. ( 29536911 )
2017

Variations for Gas Gangrene

Expression for Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for Gas Gangrene

Pathways related to Gas Gangrene according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 DMD HSPG2

GO Terms for Gas Gangrene

Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.63 CPE HSPG2 MB NEU1 PIK3C2A PLA2G2A
2 cytoplasmic vesicle GO:0031410 9.56 CPE NEU1 PIK3C2A PRF1
3 secretory granule GO:0030141 9.13 CPE DMD PLA2G2A
4 myofibril GO:0030016 8.8 DMD MYOD1 TNNI3

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 9.26 DMD MYOD1
2 cardiac muscle contraction GO:0060048 9.16 DMD TNNI3
3 muscle filament sliding GO:0030049 8.96 DMD TNNI3
4 myotube cell development GO:0014904 8.62 DMD MYOD1

Sources for Gas Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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