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MCID: GSG001
MIFTS: 52

Gas Gangrene

Categories: Infectious diseases, Muscle diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gas Gangrene

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MalaCards integrated aliases for Gas Gangrene:

Name: Gas Gangrene 12 54 44 15 37 17 71 32
Myonecrosis 12 71
Gas Bacillus Infection 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9159
ICD9CM 34 040.0
MeSH 44 D005738
SNOMED-CT 67 186413007
ICD10 32 A48.0
UMLS 71 C0017105 C0235957
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Summaries for Gas Gangrene

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Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary : Gas Gangrene, also known as myonecrosis, is related to tetanus and myoglobinuria, and has symptoms including myoclonus, torticollis and muscle cramp. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways are Dilated cardiomyopathy and Salivary secretion. The drugs Atorvastatin and Lipid Regulating Agents have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, skin and colon, and related phenotypes are homeostasis/metabolism and behavior/neurological

Wikipedia : 74 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

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Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 433)
# Related Disease Score Top Affiliating Genes
1 tetanus 30.9 NEU1 MB IL6 CRP
2 myoglobinuria 30.5 PIK3C2A MB DMD
3 necrotizing fasciitis 30.4 PRF1 IL6 CRP
4 toxic myocarditis 30.4 TNNI3 PIK3C2A
5 compartment syndrome 30.3 PIK3C2A MB IL6 CRP
6 pyomyositis 30.3 PIK3C2A MB CRP
7 acute pancreatitis 30.2 SERPINA3 PLA2G2A IL6 CRP CPB1
8 anuria 30.2 PIK3C2A MB CRP
9 disseminated intravascular coagulation 30.2 PIK3C2A MB IL6 CRP CPB2
10 myositis 30.1 SERPINA3 PIK3C2A MB IL6 DMD
11 myocarditis 30.1 TNNI3 PIK3C2A MB IL6 DMD
12 exanthem 30.0 PIK3C2A IL6 CRP
13 muscular dystrophy 30.0 TNNT2 PIK3C2A MYOD1 MB HSPG2 DMD
14 leiomyosarcoma 29.9 SERPINA3 MYOG MB
15 arteries, anomalies of 29.8 TNNI3 SERPINA3 IL6 CRP
16 pulmonary embolism 29.8 TNNT2 TNNI3 MB CRP CPB2
17 pericarditis 29.8 TNNT2 TNNI3 IL6 CRP
18 pancreatitis 29.7 SERPINA3 PLA2G2A IL6 CRP CPB1
19 angina pectoris 29.7 TNNI3 PIK3C2A MB IL6 CRP
20 spindle cell sarcoma 29.7 SERPINA3 MYOG IL6
21 aspiration pneumonia 29.6 SERPINA3 PIK3C2A IL6 CRP
22 endophthalmitis 29.6 PRF1 IL6 CRP
23 endocarditis 29.6 TNNI3 PIK3C2A IL6 CRP
24 chronic kidney disease 29.5 TNNT2 TNNI3 SERPINA3 IL6 CRP
25 muscular dystrophy, duchenne type 29.5 TNNT2 TNNI3 PIK3C2A MYOG MYOD1 MB
26 intermediate coronary syndrome 29.4 TNNT2 TNNI3 PIK3C2A MB IL6 CRP
27 peripheral nervous system disease 29.4 SERPINA3 MYOG IL6 DMD CRP
28 respiratory failure 29.4 SERPINA3 PIK3C2A IL6 DMD CRP
29 hypertrophic cardiomyopathy 29.1 TNNT2 TNNI3 PIK3C2A MB IL6 DMD
30 pneumonia 29.1 PRF1 PIK3C2A NEU1 MB IL6 CRP
31 acute myocardial infarction 29.1 TNNT2 TNNI3 SERPINA3 PIK3C2A MB IL6
32 myocardial infarction 28.8 TNNT2 TNNI3 SERPINA3 PIK3C2A MB IL6
33 myopathy 28.8 TNNT2 TNNI3 SERPINA3 PIK3C2A MYOG MYOD1
34 lipoprotein quantitative trait locus 28.8 TNNT2 TNNI3 SERPINA3 PLA2G2A PLA2G10 PIK3C2A
35 anthrax disease 11.2
36 cellulitis 10.5
37 toxic shock syndrome 10.5
38 epidemic pleurodynia 10.4 PIK3C2A MB
39 virus associated hemophagocytic syndrome 10.4 PIK3C2A MB
40 anteroseptal myocardial infarction 10.4 PIK3C2A MB
41 fasciitis 10.4
42 panophthalmitis 10.4
43 orbital plasma cell granuloma 10.4 PIK3C2A CRP
44 surfactant dysfunction 10.4 PLA2G2D PLA2G2A
45 chronic orbital inflammation 10.4 PIK3C2A CRP
46 xanthogranulomatous pyelonephritis 10.4 SERPINA3 CRP
47 inferior myocardial infarction 10.3 TNNI3 PIK3C2A
48 malignant granular cell myoblastoma 10.3 SERPINA3 MB
49 gastric dilatation 10.3 TNNI3 CRP
50 hemopericardium 10.3 TNNI3 CRP

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to Gas Gangrene
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Symptoms & Phenotypes for Gas Gangrene

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UMLS symptoms related to Gas Gangrene:


myoclonus, torticollis, muscle cramp

MGI Mouse Phenotypes related to Gas Gangrene:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CPB1 CPB2 CPE CRP DMD HSPG2
2 behavior/neurological MP:0005386 10.18 CPE DMD HSPG2 IL4I1 IL6 MYOG
3 cardiovascular system MP:0005385 10.18 CRP DMD HSPG2 IL4I1 IL6 MB
4 growth/size/body region MP:0005378 10.13 CPB2 CPE DMD HSPG2 IL6 MB
5 mortality/aging MP:0010768 10 CPB2 DMD HSPG2 IL4I1 IL6 MB
6 muscle MP:0005369 9.7 CPE DMD HSPG2 IL6 MB MYOD1
7 respiratory system MP:0005388 9.32 CPB2 CPE DMD HSPG2 IL6 MB
Sources

Drugs & Therapeutics for Gas Gangrene

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Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atorvastatin Approved Phase 4 134523-00-5 60823
2 Lipid Regulating Agents Phase 4
3 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
4 Hypolipidemic Agents Phase 4
5 Antimetabolites Phase 4
6 Anticholesteremic Agents Phase 4
7
Adenosine Approved, Investigational Phase 3 58-61-7 60961
8 Platelet Aggregation Inhibitors Phase 3
9 Purinergic P2Y Receptor Antagonists Phase 3
10 Neurotransmitter Agents Phase 3
11 Analgesics Phase 3
12 Vasodilator Agents Phase 3
13 Anti-Arrhythmia Agents Phase 3
14
Glyburide Approved Phase 2 10238-21-8 3488
15
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
16 Hypoglycemic Agents Phase 2
17 Immunologic Factors Phase 2
18 Immunoglobulin G Phase 2
19 Immunoglobulins Phase 2
20 gamma-Globulins Phase 2
21 Immunoglobulins, Intravenous Phase 2
22 Antibodies Phase 2
23 Rho(D) Immune Globulin Phase 2
24
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
25
Protein C Approved
26
Clopidogrel Approved 120202-66-6, 113665-84-2 60606
27 Angiotensin-Converting Enzyme Inhibitors

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Effects of Single-Dose Atorvastatin on Peri-Procedural Myonecrosis During Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes - The NO-MI Study Terminated NCT00344019 Phase 4 Placebo Oral Tablet;Atorvastatin 80mg
2 Optimal P2Y12-receptor treatmeNt Guided by bedSIDe Genetic or Pharmacodynamic TESTing to Prevent Periprocedural Myonecrosis During Elective Percutaneous Coronary Intervention. Unknown status NCT01930773 Phase 3
3 Randomized Comparison of Adenosin Intracoronary Infusion and Clopidogrel Pretreatment on Myonecrosis Occurence in Elective PCI Unknown status NCT00751491 Phase 3 Adenosin;Clopidogrel
4 Prevention of Cardiac and Vascular Periprocedural Complications in Patients Undergoing Coronary Angiography or Angioplasty: Intracoronary Adenosine Administration to Prevent Periprocedural Myonecrosis in Elective Coronary Angioplasty. A Prospective Double-blind Randomized Trial. Completed NCT01148147 Phase 3 Adenosine;Placebo
5 Prophylactic Intra-coronary Adenosine to Prevent Post Coronary Artery Stenting Myonecrosis Terminated NCT00612521 Phase 3 Adenosine
6 A Randomized, Multi-center, Prospective, Double Blind, Phase II Trial of RP- 1127 (Glyburide for Injection) in Patients With a Severe Anterior Circulation Ischemic Stroke Who Are Likely to Develop Malignant Edema Unknown status NCT01794182 Phase 2 RP-1127 (Glyburide for Injection)
7 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
8 A Prospective, Non-Randomized, Open-Label Study on the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
9 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
10 Angiotensin Converting Enzyme Inhibitor Therapy and Periprocedural Myocardial Infarction in Patients With Metabolic Syndrome Completed NCT02054390
11 Biomarkers in Necrotizing Soft Tissue Infections - Aspects of the Innate Immune Response Completed NCT02180906
12 Biomarkers in Necrotizing Soft Tissue Infections - Effects of Hyperbaric Oxygen Treatment on the Immune Response Completed NCT02501382
13 ProTreat - Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Completed NCT03147352
14 COronary SIde Branch Residual IschemiA and COllateralization Assessment Study (COSIBRIA & Co Study) Completed NCT01268228
15 Effects of Short Term, High Dose Atorvastatin Therapy on Periprocedural Myonecrosis and Platelet Inhibition After PCI Terminated NCT00979940 Atorvastatin

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Cochrane evidence based reviews: gas gangrene

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Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

40
Skeletal Muscle, Skin, Colon, Uterus, Eye, Endothelial, Liver
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Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50) (show all 3170)
# Title Authors PMID Year
1
Enhanced production of phospholipase C and perfringolysin O (alpha and theta toxins) in a gatifloxacin-resistant strain of Clostridium perfringens. 61 54
18160514 2008
2
Clostridium perfringens phospholipase C-induced platelet/leukocyte interactions impede neutrophil diapedesis. 61 54
16585634 2006
3
Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens. 54 61
10950774 2000
4
Changes in basement membrane components in an experimental model of skeletal muscle degeneration and regeneration induced by snake venom and myotoxic phospholipase A2. 61
33460638 2021
5
Studies on infectious myonecrosis virus (IMNV) and infectious hypodermal and hematopoietic necrosis virus (IHHNV) in cultured penaeid shrimp in Egypt. 61
33570040 2021
6
In-solution structural studies involving a phospholipase A2-like myotoxin and a natural inhibitor: Plasticity of oligomeric assembly affects mechanisms of inhibition. 61
33333169 2021
7
Impact of the Polymorphism rs5751876 of the Purinergic Receptor ADORA2A on Periprocedural Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention. 61
33342966 2021
8
Cardiotoxic Effects of Micrurus surinamensis (Cuvier, 1817) Snake Venom. 61
33559838 2021
9
Essential oil combinations against Clostridium perfringens and Clostridium septicum - the causative agents of gas gangrene. 61
33555103 2021
10
Analyzing Outcomes Among Older Adults With Necrotizing Soft-Tissue Infections in the United States. 61
32818779 2021
11
Evaluation of Linezolid Pharmacokinetics in Critically Ill Obese Patients with Severe Skin and Soft Tissue Infections. 61
33257446 2021
12
Effects of photobiomodulation therapy on the local experimental envenoming by Bothrops leucurus snake. 61
33234463 2021
13
Intratumoral Injection of Clostridium novyi-NT Spores in Patients with Treatment-refractory Advanced Solid Tumors. 61
33046513 2021
14
Myocardial Calcification and the Demise of an Infant With Surgically Treated Hypoplastic Left Heart Syndrome. 61
33433253 2021
15
Microbubble-Facilitated Ultrasound Catheter Ablation Causes Microvascular Damage and Fibrosis. 61
33092899 2021
16
Delayed bowel perforation in electrocution: An unpredictable foe. 61
33225038 2020
17
Biochemical, pharmacological and structural characterization of BmooMP-I, a new P-I metalloproteinase from Bothrops moojeni venom. 61
32946987 2020
18
PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study. 61
33028101 2020
19
COVID-19 in Patients With Hematologic-Oncologic Risk Factors: Complications in Three Patients. 61
33489484 2020
20
A rare case of Clostridium paraputrificum bacteremia in a 78-year-old Caucasian man diagnosed with an intestinal neoplasm. 61
33171286 2020
21
Extensive gas gangrene secondary to an infected epidermal cyst on the back. 61
33277696 2020
22
Gas gangrene-associated gliding motility is regulated by the Clostridium perfringens CpAL/VirSR system. 61
33130105 2020
23
Clostridial Gas Gangrene - A Rare but Deadly Infection: Case series and Comparison to Other Necrotizing Soft Tissue Infections. 61
33015993 2020
24
Edema, hyperalgesia and myonecrosis induced by Brazilian bothropic venoms: overview of the last decade. 61
32846146 2020
25
Polymorphonuclear neutrophil leukocytes in snakebite envenoming. 61
32956681 2020
26
Fish oil attenuated dystrophic muscle markers of inflammation via FFA1 and FFA4 in the mdx mouse model of DMD. 61
33136305 2020
27
Ticagrelor versus clopidogrel in elective percutaneous coronary intervention (ALPHEUS): a randomised, open-label, phase 3b trial. 61
33202219 2020
28
Postmortem computed tomography of gas gangrene with aortic gas in a dialysis patient. 61
32323214 2020
29
Pancreas Gas Gangrene Caused by Klebsiella pneumoniae. 61
32669504 2020
30
Graft-Versus-Host Disease Presenting as a Myositis and Myonecrosis. 61
32701802 2020
31
Hereditary spherocytosis: a risk factor for thigh pressure myonecrosis in posterior spine surgery. 61
31651750 2020
32
Clostridium perfringens α-toxin specifically induces endothelial cell death by promoting ceramide-mediated apoptosis. 61
32828915 2020
33
Cardiovascular activity of Micrurus lemniscatus lemniscatus (South American coralsnake) venom. 61
32755648 2020
34
Clostridium perfringens α-toxin inhibits myogenic differentiation of C2C12 myoblasts. 61
32860931 2020
35
Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient. 61
33040432 2020
36
Clinical Rhabdomyolysis With Acute Kidney Injury Secondary to High-Intensity Rosuvastatin Use: A Case Report. 61
33194498 2020
37
Dystrophic Dmdmdx rats show early neuronal changes (increased S100β and Tau5) at 8 months, supporting severe dystropathology in this rodent model of Duchenne muscular dystrophy. 61
32890728 2020
38
A different type of acute myocarditis: a case report of acute autoimmune myocarditis mediated by anti-PD-1 T lymphocyte receptor (pembrolizumab). 61
33204987 2020
39
Analysis of wound exudates reveals differences in the patterns of tissue damage and inflammation induced by the venoms of Daboia russelii and Bothrops asper in mice. 61
32781076 2020
40
Emerging erythromycin and clindamycin resistance in group A streptococci: Efficacy of linezolid and tedizolid in experimental necrotizing infection. 61
32408046 2020
41
A brief review on the natural history, venomics and the medical importance of bushmaster (Lachesis) pit viper snakes. 61
32793880 2020
42
Muscle proteolysis via ubiquitin-proteasome system (UPS) is activated by BthTx-I Lys49 PLA2 but not by BthTx-II Asp49 PLA2 and Bothrops jararacussu venom. 61
32619552 2020
43
Sidewinder gait in horses. 61
32820825 2020
44
The Italian mobile surgical units in the Great War: the modernity of the past. 61
32876884 2020
45
Statin Associated Autoimmune Myonecrosis: Case Report With Delayed Onset and Treatment Challenges. 61
32924771 2020
46
Weakness Due to Anemia? Go Fish! Melena as a Red Herring in the Diagnosis of Statin-Induced Myopathy. 61
33145125 2020
47
SUPPORT-1 (Subjects Undergoing PCI and Perioperative Reperfusion Treatment): A Prospective, Randomized Trial of CMX-2043 in Patients Undergoing Elective Percutaneous Coronary Intervention. 61
32769849 2020
48
Cardiac and skeletal muscle changes associated with rosuvastatin therapy in dystrophic mdx mice. 61
31855314 2020
49
Factors associated with myonecrosis at time of fasciotomy in acute leg compartment syndrome. 61
32350597 2020
50
Toxinological characterization of venom from Leptodeira annulata (Banded cat-eyed snake; Dipsadidae, Imantodini). 61
32302625 2020
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Variations for Gas Gangrene

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Expression for Gas Gangrene

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Search GEO for disease gene expression data for Gas Gangrene.
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Pathways for Gas Gangrene

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Pathways related to Gas Gangrene according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Dilated cardiomyopathy 36
Show member pathways
 11.83 TNNT2 TNNI3 IL6 DMD
2
Salivary secretion 36
Show member pathways
 11.79 PLA2G2D PLA2G2A PLA2G10 CPB2 CPB1
3
Striated Muscle Contraction 65 1
11.36 TNNT2 TNNI3 DMD
4
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.08 TNNT2 TNNI3 MYOG MYOD1 IL6 HSPG2
5
Fat digestion and absorption 36
Show member pathways
 10.99 PLA2G2D PLA2G2A PLA2G10
Sources

GO Terms for Gas Gangrene

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Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 SERPINA3 PLA2G2A PLA2G10 IL6 HSPG2 CRP
2 cytoplasmic vesicle GO:0031410 9.85 PRF1 PLA2G10 PIK3C2A NEU1 IL4I1 CPE
3 extracellular region GO:0005576 9.44 SERPINA3 PRF1 PLA2G2D PLA2G2A PLA2G10 NEU1
4 troponin complex GO:0005861 9.4 TNNT2 TNNI3
5 cardiac myofibril GO:0097512 9.32 TNNT2 TNNI3
6 myofibril GO:0030016 9.26 TNNT2 TNNI3 MYOD1 DMD
7 cardiac Troponin complex GO:1990584 9.16 TNNT2 TNNI3

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 lipid catabolic process GO:0016042 9.8 PLA2G2D PLA2G2A PLA2G10 NEU1
2 phospholipid metabolic process GO:0006644 9.79 PLA2G2D PLA2G2A PLA2G10
3 skeletal muscle tissue development GO:0007519 9.74 MYOG MYOD1 DMD
4 phosphatidic acid biosynthetic process GO:0006654 9.73 PLA2G2D PLA2G2A PLA2G10
5 inflammatory response GO:0006954 9.73 SERPINA3 PLA2G2D PLA2G2A IL6 HSPG2 CRP
6 cardiac muscle contraction GO:0060048 9.71 TNNT2 TNNI3 DMD
7 acute-phase response GO:0006953 9.7 SERPINA3 IL6 CRP
8 muscle filament sliding GO:0030049 9.69 TNNT2 TNNI3 DMD
9 phosphatidylcholine acyl-chain remodeling GO:0036151 9.65 PLA2G2D PLA2G2A PLA2G10
10 myotube differentiation GO:0014902 9.63 MYOG MYOD1
11 phosphatidylethanolamine acyl-chain remodeling GO:0036152 9.63 PLA2G2D PLA2G2A PLA2G10
12 negative regulation of ATPase activity GO:0032780 9.62 TNNT2 TNNI3
13 response to denervation involved in regulation of muscle adaptation GO:0014894 9.62 MYOG DMD
14 positive regulation of skeletal muscle fiber development GO:0048743 9.61 MYOG MYOD1
15 arachidonic acid secretion GO:0050482 9.61 PLA2G2D PLA2G2A PLA2G10
16 negative regulation of lipid storage GO:0010888 9.6 IL6 CRP
17 phosphatidylglycerol metabolic process GO:0046471 9.59 PLA2G2D PLA2G10
18 phosphatidic acid metabolic process GO:0046473 9.58 PLA2G2A PLA2G10
19 muscle cell fate commitment GO:0042693 9.58 MYOG MYOD1
20 skeletal muscle tissue regeneration GO:0043403 9.58 MYOG MYOD1 DMD
21 myotube cell development GO:0014904 9.55 MYOD1 DMD
22 phosphatidylserine acyl-chain remodeling GO:0036150 9.54 PLA2G2D PLA2G2A PLA2G10
23 phosphatidylcholine metabolic process GO:0046470 9.5 PLA2G2D PLA2G2A PLA2G10
24 phosphatidylinositol acyl-chain remodeling GO:0036149 9.33 PLA2G2D PLA2G2A PLA2G10
25 phosphatidylglycerol acyl-chain remodeling GO:0036148 9.13 PLA2G2D PLA2G2A PLA2G10
26 phosphatidylethanolamine metabolic process GO:0046337 8.8 PLA2G2D PLA2G2A PLA2G10

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.18 TNNI3 PRF1 PLA2G2D PLA2G2A PLA2G10 MB
2 calcium ion binding GO:0005509 9.93 PRF1 PLA2G2D PLA2G2A PLA2G10 HSPG2 CRP
3 carboxypeptidase activity GO:0004180 9.61 CPE CPB2 CPB1
4 phospholipase A2 activity GO:0004623 9.5 PLA2G2D PLA2G2A PLA2G10
5 metallocarboxypeptidase activity GO:0004181 9.43 CPE CPB2 CPB1
6 troponin C binding GO:0030172 9.37 TNNT2 TNNI3
7 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) GO:0102568 9.33 PLA2G2D PLA2G2A PLA2G10
8 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) GO:0102567 9.13 PLA2G2D PLA2G2A PLA2G10
9 calcium-dependent phospholipase A2 activity GO:0047498 8.8 PLA2G2D PLA2G2A PLA2G10
Sources

Sources for Gas Gangrene

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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