MCID: GST008
MIFTS: 37

Gastric Adenosquamous Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Adenosquamous Carcinoma

MalaCards integrated aliases for Gastric Adenosquamous Carcinoma:

Name: Gastric Adenosquamous Carcinoma 12 15 73
Adenosquamous Carcinoma of Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5635
NCIt 50 C5474
UMLS 73 C1333761

Summaries for Gastric Adenosquamous Carcinoma

MalaCards based summary : Gastric Adenosquamous Carcinoma, also known as adenosquamous carcinoma of stomach, is related to adenosquamous carcinoma and cholangiolocellular carcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Adenosquamous Carcinoma is TFRC (Transferrin Receptor), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include lung, brain and bone, and related phenotypes are cellular and cardiovascular system

Related Diseases for Gastric Adenosquamous Carcinoma

Diseases related to Gastric Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 10.5
2 cholangiolocellular carcinoma 10.2 CDKN2A PROM1
3 protoplasmic astrocytoma 10.1 SRC TP53
4 gallbladder adenocarcinoma 10.1 PROM1 SRC
5 breast giant fibroadenoma 10.1 CD44 CDKN2A
6 lichen sclerosus 10.1 CD44 TP53
7 bladder squamous cell carcinoma 10.1 CDKN2A TP53
8 keratinizing squamous cell carcinoma 10.1 CDKN2A TP53
9 spitz nevus 10.1 CDKN2A TP53
10 bladder carcinoma in situ 10.1 CDKN2A TP53
11 vulva squamous cell carcinoma 10.1 CDKN2A TP53
12 scrotal carcinoma 10.1 CDKN2A TP53
13 vulvar disease 10.1 CDKN2A TP53
14 nasal cavity adenocarcinoma 10.1 CDKN2A TP53
15 bartholin's gland disease 10.1 CDKN2A TP53
16 anal squamous cell carcinoma 10.1 CDKN2A TP53
17 megaesophagus 10.1 CDKN2A TP53
18 glycogen-rich clear cell breast carcinoma 10.1 CDKN2A TP53
19 anogenital venereal wart 10.1 CDKN2A TP53
20 cervix uteri carcinoma in situ 10.1 CDKN2A TP53
21 uterus carcinoma in situ 10.1 CDKN2A TP53
22 oral leukoplakia 10.1 CDKN2A TP53
23 meningeal melanomatosis 10.1 CDKN2A TP53
24 suppressor of tumorigenicity 3 10.1 CDKN2A TP53
25 dedifferentiated liposarcoma 10.1 CDKN2A TP53
26 endocervical adenocarcinoma 10.1 CDKN2A TP53
27 skin carcinoma in situ 10.1 CDKN2A STAT3
28 penile disease 10.1 CDKN2A TP53
29 bone squamous cell carcinoma 10.1 CDKN2A STAT3
30 cervix small cell carcinoma 10.0 CDKN2A TP53
31 necrotizing sialometaplasia 10.0 CDKN2A TP53
32 verrucous carcinoma 10.0 CDKN2A TP53
33 basaloid squamous cell carcinoma 10.0 CDKN2A TP53
34 tongue disease 10.0 CDKN2A TP53
35 biliary tract neoplasm 10.0 CDKN2A TP53
36 optic nerve neoplasm 10.0 CDKN2A TP53
37 juvenile pilocytic astrocytoma 10.0 CDKN2A TP53
38 tonsil cancer 10.0 CDKN2A TP53
39 spinal cord astrocytoma 10.0 CD44 PROM1 TP53
40 pre-malignant neoplasm 10.0 CDKN2A TP53
41 cerebral primitive neuroectodermal tumor 10.0 CD44 SRC TP53
42 recessive dystrophic epidermolysis bullosa 10.0 CDKN2A TP53
43 laryngeal disease 10.0 CDKN2A PROM1 TP53
44 central nervous system cancer 10.0 CDKN2A PROM1 TP53
45 nervous system cancer 10.0 CDKN2A PROM1 TP53
46 vulva cancer 10.0 CDKN2A TP53
47 squamous cell papilloma 10.0 CDKN2A TP53
48 reproductive system disease 9.9 CD44 CDKN2A TP53
49 larynx cancer 9.9 CD44 CDKN2A TP53
50 small cell cancer of the lung 9.9 CD44 CDKN2A TP53

Graphical network of the top 20 diseases related to Gastric Adenosquamous Carcinoma:



Diseases related to Gastric Adenosquamous Carcinoma

Symptoms & Phenotypes for Gastric Adenosquamous Carcinoma

UMLS symptoms related to Gastric Adenosquamous Carcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Adenosquamous Carcinoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.08 CD44 CDKN2A ITGA6 PROM1 SRC STAT3
2 cardiovascular system MP:0005385 10.04 CD44 CDKN2A ITGA6 PROM1 STAT3 TFRC
3 growth/size/body region MP:0005378 10.01 CD44 CDKN2A ITGA6 PROM1 SRC STAT3
4 digestive/alimentary MP:0005381 9.93 CD44 CDKN2A ITGA6 STAT3 TFRC TP53
5 embryo MP:0005380 9.91 CDKN2A ITGA6 SRC STAT3 TFRC TP53
6 integument MP:0010771 9.91 CD44 CDKN2A ITGA6 SRC STAT3 TFRC
7 neoplasm MP:0002006 9.87 CD44 CDKN2A ITGA6 PROM1 SRC STAT3
8 nervous system MP:0003631 9.86 CD44 CDKN2A ITGA6 PROM1 SRC STAT3
9 pigmentation MP:0001186 9.55 CD44 CDKN2A PROM1 SRC TP53
10 respiratory system MP:0005388 9.43 CD44 CDKN2A ITGA6 SRC STAT3 TP53
11 vision/eye MP:0005391 9.17 CD44 CDKN2A ITGA6 PROM1 SRC STAT3

Drugs & Therapeutics for Gastric Adenosquamous Carcinoma

Search Clinical Trials , NIH Clinical Center for Gastric Adenosquamous Carcinoma

Genetic Tests for Gastric Adenosquamous Carcinoma

Anatomical Context for Gastric Adenosquamous Carcinoma

MalaCards organs/tissues related to Gastric Adenosquamous Carcinoma:

41
Lung, Brain, Bone, Colon, Spinal Cord, Pancreas, Cervix

Publications for Gastric Adenosquamous Carcinoma

Articles related to Gastric Adenosquamous Carcinoma:

(show all 12)
# Title Authors Year
1
Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor: a case of a rare malignancy. ( 28493097 )
2017
2
Clinicopathological features and prognosis of gastric adenosquamous carcinoma. ( 28676632 )
2017
3
Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma. ( 25889482 )
2015
4
Fatal submucosal invasive gastric adenosquamous carcinoma detected at surveillance after gastric endoscopic submucosal dissection. ( 25892891 )
2015
5
Fever as a first manifestation of advanced gastric adenosquamous carcinoma: a case report. ( 25110448 )
2014
6
Durable response of human epidermal growth factor receptor-2-positive gastric adenosquamous carcinoma to trastuzumab-based chemotherapy. ( 24803897 )
2014
7
Primary gastric adenosquamous carcinoma in an Indian male. ( 24441236 )
2013
8
Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells. ( 21523522 )
2012
9
A patient with gastric adenosquamous carcinoma with intraperitoneal free cancer cells who remained recurrence-free with postoperative S-1 chemotherapy. ( 23154717 )
2012
10
Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. ( 21034475 )
2010
11
Weekly paclitaxel therapy is effective for gastric adenosquamous carcinoma: a case report. ( 19579645 )
2009
12
Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor. ( 16086120 )
2005

Variations for Gastric Adenosquamous Carcinoma

Expression for Gastric Adenosquamous Carcinoma

Search GEO for disease gene expression data for Gastric Adenosquamous Carcinoma.

Pathways for Gastric Adenosquamous Carcinoma

Pathways related to Gastric Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 CDKN2A SRC STAT3 TP53
2 12.57 CDKN2A ITGA6 STAT3 TP53
3
Show member pathways
12.47 CDKN2A SRC STAT3 TP53
4 12.18 CD44 CDKN2A STAT3 TP53
5
Show member pathways
12.13 ITGA6 SRC STAT3
6 12.06 CD44 STAT3 TP53
7
Show member pathways
12.03 SRC STAT3 TP53
8
Show member pathways
12 CD44 ITGA6 SRC
9 11.93 SRC STAT3 TP53
10 11.76 CD44 SRC STAT3 TP53
11
Show member pathways
11.75 SRC STAT3 TP53
12 11.68 CDKN2A SRC TP53
13 11.6 CD44 ITGA6 TFRC
14 11.56 CDKN2A SRC STAT3 TP53
15 11.43 ITGA6 SRC STAT3
16 11.36 CDKN2A SRC TP53
17 11.14 CD44 STAT3 TP53
18 11.1 CDKN2A TP53
19 10.96 SRC STAT3
20 10.95 CD44 CDKN2A SRC TP53
21 10.87 CDKN2A TP53
22
Show member pathways
10.85 CDKN2A TP53

GO Terms for Gastric Adenosquamous Carcinoma

Cellular components related to Gastric Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD44 ITGA6 PROM1 TFRC
2 basolateral plasma membrane GO:0016323 8.8 CD44 ITGA6 TFRC

Biological processes related to Gastric Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.81 CDKN2A SRC STAT3 TP53
2 negative regulation of apoptotic process GO:0043066 9.8 CD44 SRC STAT3 TP53
3 viral process GO:0016032 9.71 SRC STAT3 TFRC TP53
4 positive regulation of gene expression GO:0010628 9.67 CDKN2A SRC STAT3 TP53
5 leukocyte migration GO:0050900 9.65 CD44 ITGA6 SRC
6 cell-cell adhesion GO:0098609 9.61 CD44 ITGA6 SRC
7 positive regulation of apoptotic process GO:0043065 9.56 CDKN2A ITGA6 SRC TP53
8 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.46 STAT3 TP53
9 replicative senescence GO:0090399 9.32 CDKN2A TP53
10 negative regulation of telomerase activity GO:0051974 9.16 SRC TP53
11 regulation of mitochondrial membrane permeability GO:0046902 8.96 STAT3 TP53
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.8 CD44 SRC TP53

Molecular functions related to Gastric Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 CDKN2A TP53
2 protein kinase binding GO:0019901 8.92 CDKN2A SRC STAT3 TP53

Sources for Gastric Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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