GAVE
MCID: GST020
MIFTS: 37

Gastric Antral Vascular Ectasia (GAVE)

Categories: Blood diseases, Cardiovascular diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Gastric Antral Vascular Ectasia

MalaCards integrated aliases for Gastric Antral Vascular Ectasia:

Name: Gastric Antral Vascular Ectasia 12 53 44 15
Watermelon Stomach 12 76 53
Gave 53

Classifications:



External Ids:

Disease Ontology 12 DOID:2493
MeSH 44 D020252
NCIt 50 C84724
SNOMED-CT 68 43935004
UMLS 73 C0267211

Summaries for Gastric Antral Vascular Ectasia

NIH Rare Diseases : 53 Watermelon stomach is a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by endoscopy. Although it can develop in men and women of all ages, watermelon stomach is most commonly observed in older women (over age 70 years). Signs and symptoms of watermelon stomach include blood in the stool, hematemesis (vomiting blood) and anemia. The exact cause of watermelon stomach is unknown; however, it is often diagnosed in people with other chronic (long-term) conditions such as cirrhosis (scarring of the liver and poor liver function), autoimmune disease, systemic sclerosis, and CREST syndrome. Treatment consists of surgery and/or medications to stop or control the bleeding.

MalaCards based summary : Gastric Antral Vascular Ectasia, also known as watermelon stomach, is related to portal hypertension and stomach disease. An important gene associated with Gastric Antral Vascular Ectasia is SST (Somatostatin). The drugs Proton Pump Inhibitors and Iron have been mentioned in the context of this disorder. Affiliated tissues include liver, myeloid and kidney.

Wikipedia : 76 Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron... more...

Related Diseases for Gastric Antral Vascular Ectasia

Diseases related to Gastric Antral Vascular Ectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 portal hypertension 30.6 CTC1 SST
2 stomach disease 29.8 SST ATP4A ATP12A
3 transcobalamin ii deficiency 11.1
4 campomelic dysplasia 11.0
5 hyperlipidemia, familial combined 11.0
6 marfan syndrome 11.0
7 pseudo-von willebrand disease 11.0
8 spherocytosis, type 1 11.0
9 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 11.0
10 smith-lemli-opitz syndrome 11.0
11 ichthyosis, x-linked 11.0
12 sacral defect with anterior meningocele 11.0
13 agammaglobulinemia 1, autosomal recessive 11.0
14 scleroderma, familial progressive 10.8
15 liver cirrhosis 10.4
16 leukemia 10.3
17 liver disease 10.3
18 angiodysplasia 10.3
19 proctitis 10.3
20 radiation proctitis 10.3
21 gastritis 10.2
22 systemic lupus erythematosus 10.2
23 crest syndrome 10.2
24 lupus erythematosus 10.2
25 biliary cirrhosis, primary, 1 10.1
26 leukemia, chronic myeloid 10.1
27 graft-versus-host disease 10.1
28 deficiency anemia 10.1
29 hemangioma 10.1
30 hematopoietic stem cell transplantation 10.1
31 primary biliary cirrhosis 10.1
32 protein-losing enteropathy 10.1
33 iron deficiency anemia 10.1
34 limited scleroderma 10.1
35 iron metabolism disease 10.1
36 capillary hemangioma 10.1
37 myeloid leukemia 10.1
38 chronic graft versus host disease 10.1
39 primary biliary cholangitis 10.1
40 solitary rectal ulcer syndrome 10.1
41 myocardial infarction 10.1
42 fungal esophagitis 10.0 ATP4A ATP12A
43 gastroduodenal crohn's disease 10.0 ATP4A ATP12A
44 diclofenac allergy 10.0 ATP4A ATP12A
45 neonatal candidiasis 10.0 ATP4A ATP12A
46 squamous papillomatosis 10.0 ATP4A ATP12A
47 photoallergic dermatitis 10.0 ATP4A ATP12A
48 aspiration pneumonitis 10.0 ATP4A ATP12A
49 toxic megacolon 10.0 ATP4A ATP12A
50 granulomatous gastritis 10.0 ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastric Antral Vascular Ectasia:



Diseases related to Gastric Antral Vascular Ectasia

Symptoms & Phenotypes for Gastric Antral Vascular Ectasia

Drugs & Therapeutics for Gastric Antral Vascular Ectasia

Drugs for Gastric Antral Vascular Ectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Proton Pump Inhibitors Phase 2, Phase 3
2
Iron Approved Phase 2,Not Applicable 7439-89-6 23925
3 Anti-Infective Agents Phase 2
4 Anti-Bacterial Agents Phase 2
5 Immunologic Factors Phase 2
6 Angiogenesis Modulating Agents Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Immunosuppressive Agents Phase 2
9
Simvastatin Approved Not Applicable 79902-63-9 54454
10
Carvedilol Approved, Investigational Not Applicable 72956-09-3 2585
11 Hydroxymethylglutaryl-CoA Reductase Inhibitors Not Applicable
12 Vasodilator Agents Not Applicable
13 Adrenergic alpha-Antagonists Not Applicable
14 Neurotransmitter Agents Not Applicable
15 Adrenergic alpha-1 Receptor Antagonists Not Applicable
16 Anticholesteremic Agents Not Applicable
17 Lipid Regulating Agents Not Applicable
18 Adrenergic beta-Antagonists Not Applicable
19 Antihypertensive Agents Not Applicable
20 Adrenergic Antagonists Not Applicable
21 Hypolipidemic Agents Not Applicable
22 Adrenergic Agents Not Applicable
23 Antimetabolites Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
2 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
3 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2 Thalidomide;Iron
4 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
5 To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices. Completed NCT02465645 Not Applicable Carvedilol;Carvedilol + Simvastatin
6 Prospective Evaluation Of Outcomes For Patients Undergoing Radiofrequency Ablation (RFA) Using HALO Ultra Device For Gastric Antral Vascular Ectasia (GAVE) Recruiting NCT03525366
7 Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT) Recruiting NCT02792023 Not Applicable
8 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395 Not Applicable

Search NIH Clinical Center for Gastric Antral Vascular Ectasia

Cochrane evidence based reviews: gastric antral vascular ectasia

Genetic Tests for Gastric Antral Vascular Ectasia

Anatomical Context for Gastric Antral Vascular Ectasia

MalaCards organs/tissues related to Gastric Antral Vascular Ectasia:

41
Liver, Myeloid, Kidney, Skin, Ovary, T Cells, Lung

Publications for Gastric Antral Vascular Ectasia

Articles related to Gastric Antral Vascular Ectasia:

(show top 50) (show all 269)
# Title Authors Year
1
Gastric Antral Vascular Ectasia: A Case Report and Literature Review. ( 29607305 )
2018
2
Insights into the management of gastric antral vascular ectasia (watermelon stomach). ( 29399041 )
2018
3
Gastric Antral Vascular Ectasia Pathogenesis and the Link to the Metabolic Syndrome. ( 29961911 )
2018
4
Radiofrequency ablation (RFA) vs. argon plasma coagulation (APC) for the management of gastric antral vascular ectasia (GAVE) in patients with and without cirrhosis: results from a retrospective analysis of a large cohort of patients treated at a single center. ( 29497685 )
2018
5
An Analysis of the Clinical, Laboratory, and Histological Features of Striped, Punctate, and Nodular Gastric Antral Vascular Ectasia. ( 29450749 )
2018
6
Case series on multimodal endoscopic therapy for gastric antral vascular ectasia, a tertiary center experience. ( 29375739 )
2018
7
Comparative Effectiveness and Safety of Radiofrequency Ablation Versus Argon Plasma Coagulation for Treatment of Gastric Antral Vascular Ectasia: A Systematic Review and Meta-Analysis. ( 29952856 )
2018
8
Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature. ( 30101944 )
2018
9
Gastric antral vascular ectasia in portal hypertensive children: Endoscopic band ligation versus argon plasma coagulation. ( 30119927 )
2018
10
Nitrous oxide cryotherapy ablation for refractory gastric antral vascular ectasia. ( 30288277 )
2018
11
Diagnosis and Management of Gastric Antral Vascular Ectasia: Experience in a Large Single Cohort of Patients With Systemic Sclerosis. ( 30431488 )
2018
12
Gastric antral vascular ectasia presenting as a polypoid mass in a patient with cirrhosis. ( 28803743 )
2017
13
Gastric antral vascular ectasia and solitary rectal ulcer syndrome - two rare diagnoses as the cause of anemia in aA single patient: case report. ( 28726433 )
2017
14
Vascular-targeted photodynamic therapy of gastric antral vascular ectasia (GAVE). ( 27871022 )
2017
15
Endoscopic Treatment for Gastric Antral Vascular Ectasia: Current Options. ( 29255747 )
2017
16
Nitrous oxide CryoBalloon therapy of refractory gastric antral vascular ectasia. ( 28679138 )
2017
17
Gastric Antral Vascular Ectasia and Metabolic Syndrome: Is There a Case for an Association? ( 29073974 )
2017
18
Gastric antral vascular ectasia in systemic sclerosis: Where do we stand? ( 28217887 )
2017
19
Endoscopic resolution and recurrence of gastric antral vascular ectasia after serial treatment with argon plasma coagulation. ( 28690769 )
2017
20
Radiofrequency Ablation for Treatment of Refractory Gastric Antral Vascular Ectasia: A Systematic Review of the Literature. ( 28835751 )
2017
21
Radiofrequency ablation using Barrx(Ar) for the endoscopic treatment of gastric antral vascular ectasia: a series of three cases and a review of the literature on treatment options. ( 28744150 )
2017
22
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
23
Orthotopic liver transplantation changes the course of gastric antral vascular ectasia: a case series from a transplant center. ( 28520574 )
2017
24
A Case of Gastric Antral Vascular Ectasia Which Was Aggravated by Acid Reducer. ( 28611555 )
2017
25
Stepwise endoscopic eradication of refractory nodular gastric antral vascular ectasia by use of detachable snare and band ligation. ( 29905245 )
2017
26
Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa. ( 27830096 )
2016
27
Gastric Antral Vascular Ectasia during the Treatment of Chronic Myelogenous Leukemia with Imatinib Mesylate. ( 26726089 )
2016
28
Treating Gastric Antral Vascular Ectasia - When Argon Therapy Is Not Enough. ( 28868470 )
2016
29
Gastric antral vascular ectasia. ( 27728256 )
2016
30
"Imatinib-induced gastric antral vascular ectasia" in a reporting system of the Japanese Adverse Drug Event Report database. ( 26980219 )
2016
31
Radiofrequency ablation of gastric antral vascular ectasia of the gastric cardia. ( 27669532 )
2016
32
Endoscopic band ligation for gastric antral vascular ectasia: time for a new indication? ( 26820079 )
2016
33
Clinical Characterization of Gastric Antral Vascular Ectasia: A Potential Manifestation of the Metabolic Syndrome. ( 27476085 )
2016
34
Radiofrequency ablation for treatment of refractory gastric antral vascular ectasia (with video). ( 26135652 )
2015
35
Gastric antral vascular ectasia: a prospective study of treatment with endoscopic band ligation. ( 25650636 )
2015
36
Development of hyperplastic polyps following argon plasma coagulation of gastric antral vascular ectasia. ( 26283860 )
2015
37
Radiofrequency ablation therapy - the grave for GAVE (gastric antral vascular ectasia)? ( 26135653 )
2015
38
Portal hypertensive gastropathy and gastric antral vascular ectasia. ( 26376475 )
2015
39
Intravenous cyclophosphamide as a therapeutic option for severe refractory gastric antral vascular ectasia in systemic sclerosis. ( 26429218 )
2015
40
Refractory gastric antral vascular ectasia: a new endoscopic approach. ( 26592837 )
2015
41
Patients with Gastric Antral Vascular Ectasia (GAVE) Are at a Higher Risk of Gastrointestinal Bleeding in the Absence of Cirrhosis. ( 26807380 )
2015
42
Autologous hematopoietic stem cell transplant for systemic sclerosis improves anemia from gastric antral vascular ectasia. ( 25729047 )
2015
43
Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia. ( 26154650 )
2015
44
Gastric Antral Vascular Ectasia (GAVE): An Overlooked Diagnosis. ( 25772970 )
2015
45
Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts. ( 26633973 )
2015
46
Dasatinib-induced gastric antral vascular ectasia in a patient with acute lymphoblastic leukaemia. ( 25855138 )
2015
47
Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia. ( 26134364 )
2015
48
Endoscopic radiofrequency ablation for APC refractory gastric antral vascular ectasia using the HALO90 system in a kidney transplant candidate. ( 25952805 )
2015
49
Portal hypertensive gastropathy and gastric antral vascular ectasia. ( 26564121 )
2015
50
Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia. ( 26398652 )
2015

Variations for Gastric Antral Vascular Ectasia

Expression for Gastric Antral Vascular Ectasia

Search GEO for disease gene expression data for Gastric Antral Vascular Ectasia.

Pathways for Gastric Antral Vascular Ectasia

GO Terms for Gastric Antral Vascular Ectasia

Biological processes related to Gastric Antral Vascular Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.46 ATP12A ATP4A
2 response to nutrient GO:0007584 9.43 OXCT1 SST
3 potassium ion import across plasma membrane GO:1990573 9.4 ATP12A ATP4A
4 potassium ion import GO:0010107 9.37 ATP12A ATP4A
5 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
6 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
8 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
9 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Gastric Antral Vascular Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Gastric Antral Vascular Ectasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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