MCID: GST020
MIFTS: 37

Gastric Antral Vascular Ectasia

Categories: Rare diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Antral Vascular Ectasia

MalaCards integrated aliases for Gastric Antral Vascular Ectasia:

Name: Gastric Antral Vascular Ectasia 12 53 44 15
Watermelon Stomach 12 76 53
Gave 53

Classifications:



External Ids:

Disease Ontology 12 DOID:2493
MeSH 44 D020252
NCIt 50 C84724
SNOMED-CT 68 412795008 43935004
UMLS 73 C0267211

Summaries for Gastric Antral Vascular Ectasia

NIH Rare Diseases : 53 Watermelon stomach is a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by endoscopy. Although it can develop in men and women of all ages, watermelon stomach is most commonly observed in older women (over age 70 years). Signs and symptoms of watermelon stomach include blood in the stool, hematemesis (vomiting blood) and anemia. The exact cause of watermelon stomach is unknown; however, it is often diagnosed in people with other chronic (long-term) conditions such as cirrhosis (scarring of the liver and poor liver function), autoimmune disease, systemic sclerosis, and CREST syndrome. Treatment consists of surgery and/or medications to stop or control the bleeding.

MalaCards based summary : Gastric Antral Vascular Ectasia, also known as watermelon stomach, is related to duodenitis and portal hypertension. An important gene associated with Gastric Antral Vascular Ectasia is SST (Somatostatin). The drugs Proton Pump Inhibitors and Iron have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and myeloid.

Wikipedia : 76 Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron... more...

Related Diseases for Gastric Antral Vascular Ectasia

Diseases related to Gastric Antral Vascular Ectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 duodenitis 30.4 ATP12A ATP4A
2 portal hypertension 29.9 CTC1 SST
3 transcobalamin ii deficiency 11.0
4 campomelic dysplasia 10.8
5 hyperlipidemia, familial combined 10.8
6 marfan syndrome 10.8
7 pseudo-von willebrand disease 10.8
8 spherocytosis, type 1 10.8
9 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 10.8
10 smith-lemli-opitz syndrome 10.8
11 ichthyosis, x-linked 10.8
12 sacral defect with anterior meningocele 10.8
13 agammaglobulinemia 1, autosomal recessive 10.8
14 scleroderma, familial progressive 10.6
15 fungal esophagitis 10.3 ATP12A ATP4A
16 bladder calculus 10.3 ATP12A ATP4A
17 neonatal candidiasis 10.3 ATP12A ATP4A
18 photoallergic dermatitis 10.3 ATP12A ATP4A
19 squamous papillomatosis 10.3 ATP12A ATP4A
20 acute laryngitis 10.3 ATP12A ATP4A
21 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
22 toxic megacolon 10.3 ATP12A ATP4A
23 aspiration pneumonitis 10.3 ATP12A ATP4A
24 postsurgical hypothyroidism 10.3 ATP12A ATP4A
25 esophageal candidiasis 10.3 ATP12A ATP4A
26 rumination disorder 10.3 ATP12A ATP4A
27 bile reflux 10.3 ATP12A ATP4A
28 granulomatous gastritis 10.3 ATP12A ATP4A
29 active peptic ulcer disease 10.3 ATP12A ATP4A
30 laryngeal disease 10.3 ATP12A ATP4A
31 ischemic neuropathy 10.3 ATP12A ATP4A
32 capillary disease 10.3 ATP12A ATP4A
33 peptic esophagitis 10.3 ATP12A ATP4A
34 duodenal disease 10.3 ATP12A ATP4A
35 hernia, hiatus 10.3 ATP12A ATP4A
36 congenital disorder of deglycosylation 10.2 ATP12A ATP4A
37 anismus 10.2 ATP12A ATP4A
38 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
39 laryngitis 10.2 ATP12A ATP4A
40 laryngeal tuberculosis 10.2 ATP12A ATP4A
41 lymphocytic colitis 10.2 ATP12A ATP4A
42 clostridium difficile colitis 10.2 ATP12A ATP4A
43 lower urinary tract calculus 10.2 ATP12A ATP4A
44 aspiration pneumonia 10.2 ATP12A ATP4A
45 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
46 chronic laryngitis 10.2 ATP12A ATP4A
47 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
48 eosinophilic gastritis 10.2 ATP12A ATP4A
49 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP12A ATP4A
50 esophagus adenocarcinoma 10.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Gastric Antral Vascular Ectasia:



Diseases related to Gastric Antral Vascular Ectasia

Symptoms & Phenotypes for Gastric Antral Vascular Ectasia

Drugs & Therapeutics for Gastric Antral Vascular Ectasia

Drugs for Gastric Antral Vascular Ectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Proton Pump Inhibitors Phase 2, Phase 3
2
Iron Approved Phase 2,Not Applicable 7439-89-6 23925
3 Angiogenesis Inhibitors Phase 2
4 Angiogenesis Modulating Agents Phase 2
5 Anti-Bacterial Agents Phase 2
6 Anti-Infective Agents Phase 2
7 Immunosuppressive Agents Phase 2
8
Carvedilol Approved, Investigational Not Applicable 72956-09-3 2585
9
Simvastatin Approved Not Applicable 79902-63-9 54454
10 Adrenergic Agents Not Applicable
11 Adrenergic alpha-1 Receptor Antagonists Not Applicable
12 Adrenergic alpha-Antagonists Not Applicable
13 Adrenergic Antagonists Not Applicable
14 Adrenergic beta-Antagonists Not Applicable
15 Anticholesteremic Agents Not Applicable
16 Antihypertensive Agents Not Applicable
17 Antimetabolites Not Applicable
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Not Applicable
19 Hypolipidemic Agents Not Applicable
20 Lipid Regulating Agents Not Applicable
21 Neurotransmitter Agents Not Applicable
22 Vasodilator Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
2 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
3 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2 Thalidomide;Iron
4 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
5 To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices. Completed NCT02465645 Not Applicable Carvedilol;Carvedilol + Simvastatin
6 Prospective Evaluation Of Outcomes For Patients Undergoing Radiofrequency Ablation (RFA) Using HALO Ultra Device For Gastric Antral Vascular Ectasia (GAVE) Recruiting NCT03525366
7 Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT) Recruiting NCT02792023 Not Applicable
8 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395 Not Applicable

Search NIH Clinical Center for Gastric Antral Vascular Ectasia

Cochrane evidence based reviews: gastric antral vascular ectasia

Genetic Tests for Gastric Antral Vascular Ectasia

Anatomical Context for Gastric Antral Vascular Ectasia

MalaCards organs/tissues related to Gastric Antral Vascular Ectasia:

41
Liver, Testes, Myeloid, Kidney

Publications for Gastric Antral Vascular Ectasia

Articles related to Gastric Antral Vascular Ectasia:

(show top 50) (show all 180)
# Title Authors Year
1
Gastric Antral Vascular Ectasia: A Case Report and Literature Review. ( 29607305 )
2018
2
Insights into the management of gastric antral vascular ectasia (watermelon stomach). ( 29399041 )
2018
3
Gastric Antral Vascular Ectasia Pathogenesis and the Link to the Metabolic Syndrome. ( 29961911 )
2018
4
Radiofrequency ablation (RFA) vs. argon plasma coagulation (APC) for the management of gastric antral vascular ectasia (GAVE) in patients with and without cirrhosis: results from a retrospective analysis of a large cohort of patients treated at a single center. ( 29497685 )
2018
5
An Analysis of the Clinical, Laboratory, and Histological Features of Striped, Punctate, and Nodular Gastric Antral Vascular Ectasia. ( 29450749 )
2018
6
Case series on multimodal endoscopic therapy for gastric antral vascular ectasia, a tertiary center experience. ( 29375739 )
2018
7
Comparative Effectiveness and Safety of Radiofrequency Ablation Versus Argon Plasma Coagulation for Treatment of Gastric Antral Vascular Ectasia: A Systematic Review and Meta-Analysis. ( 29952856 )
2018
8
Gastric antral vascular ectasia presenting as a polypoid mass in a patient with cirrhosis. ( 28803743 )
2017
9
Gastric antral vascular ectasia and solitary rectal ulcer syndrome - two rare diagnoses as the cause of anemia in aA single patient: case report. ( 28726433 )
2017
10
Vascular-targeted photodynamic therapy of gastric antral vascular ectasia (GAVE). ( 27871022 )
2017
11
Endoscopic Treatment for Gastric Antral Vascular Ectasia: Current Options. ( 29255747 )
2017
12
Nitrous oxide CryoBalloon therapy of refractory gastric antral vascular ectasia. ( 28679138 )
2017
13
Gastric Antral Vascular Ectasia and Metabolic Syndrome: Is There a Case for an Association? ( 29073974 )
2017
14
Gastric antral vascular ectasia in systemic sclerosis: Where do we stand? ( 28217887 )
2017
15
Endoscopic resolution and recurrence of gastric antral vascular ectasia after serial treatment with argon plasma coagulation. ( 28690769 )
2017
16
Radiofrequency Ablation for Treatment of Refractory Gastric Antral Vascular Ectasia: A Systematic Review of the Literature. ( 28835751 )
2017
17
Radiofrequency ablation using Barrx(Ar) for the endoscopic treatment of gastric antral vascular ectasia: a series of three cases and a review of the literature on treatment options. ( 28744150 )
2017
18
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
19
A Case of Gastric Antral Vascular Ectasia Which Was Aggravated by Acid Reducer. ( 28611555 )
2017
20
Orthotopic liver transplantation changes the course of gastric antral vascular ectasia: a case series from a transplant center. ( 28520574 )
2017
21
Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa. ( 27830096 )
2016
22
Gastric Antral Vascular Ectasia during the Treatment of Chronic Myelogenous Leukemia with Imatinib Mesylate. ( 26726089 )
2016
23
Treating Gastric Antral Vascular Ectasia - When Argon Therapy Is Not Enough. ( 28868470 )
2016
24
Gastric antral vascular ectasia. ( 27728256 )
2016
25
Radiofrequency ablation of gastric antral vascular ectasia of the gastric cardia. ( 27669532 )
2016
26
Clinical Characterization of Gastric Antral Vascular Ectasia: A Potential Manifestation of the Metabolic Syndrome. ( 27476085 )
2016
27
Endoscopic band ligation for gastric antral vascular ectasia: time for a new indication? ( 26820079 )
2016
28
Radiofrequency ablation for treatment of refractory gastric antral vascular ectasia (with video). ( 26135652 )
2015
29
Gastric antral vascular ectasia: a prospective study of treatment with endoscopic band ligation. ( 25650636 )
2015
30
Development of hyperplastic polyps following argon plasma coagulation of gastric antral vascular ectasia. ( 26283860 )
2015
31
Radiofrequency ablation therapy - the grave for GAVE (gastric antral vascular ectasia)? ( 26135653 )
2015
32
Portal hypertensive gastropathy and gastric antral vascular ectasia. ( 26376475 )
2015
33
Intravenous cyclophosphamide as a therapeutic option for severe refractory gastric antral vascular ectasia in systemic sclerosis. ( 26429218 )
2015
34
Refractory gastric antral vascular ectasia: a new endoscopic approach. ( 26592837 )
2015
35
Patients with Gastric Antral Vascular Ectasia (GAVE) Are at a Higher Risk of Gastrointestinal Bleeding in the Absence of Cirrhosis. ( 26807380 )
2015
36
Autologous hematopoietic stem cell transplant for systemic sclerosis improves anemia from gastric antral vascular ectasia. ( 25729047 )
2015
37
Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia. ( 26154650 )
2015
38
Gastric Antral Vascular Ectasia (GAVE): An Overlooked Diagnosis. ( 25772970 )
2015
39
Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts. ( 26633973 )
2015
40
Dasatinib-induced gastric antral vascular ectasia in a patient with acute lymphoblastic leukaemia. ( 25855138 )
2015
41
Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia. ( 26134364 )
2015
42
Endoscopic radiofrequency ablation for APC refractory gastric antral vascular ectasia using the HALO90 system in a kidney transplant candidate. ( 25952805 )
2015
43
Portal hypertensive gastropathy and gastric antral vascular ectasia. ( 26564121 )
2015
44
Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia. ( 26398652 )
2015
45
Transjugular intrahepatic portosystemic shunt as bridge-to-surgery in refractory gastric antral vascular ectasia. ( 25987803 )
2015
46
Microvascular architecture in a case of gastric antral vascular ectasia (watermelon stomach). ( 24594964 )
2014
47
Radiofrequency Ablation of Treatment-refractory Gastric Antral Vascular Ectasia (GAVE). ( 24743681 )
2014
48
Gastric antral vascular ectasia unresponsive to endoscopic treatment requiring antrectomy. ( 25240797 )
2014
49
Watermelon stomach: gastric antral vascular ectasia. ( 25475404 )
2014
50
Gastric Antral Vascular Ectasia. ( 26259325 )
2014

Variations for Gastric Antral Vascular Ectasia

Expression for Gastric Antral Vascular Ectasia

Search GEO for disease gene expression data for Gastric Antral Vascular Ectasia.

Pathways for Gastric Antral Vascular Ectasia

GO Terms for Gastric Antral Vascular Ectasia

Biological processes related to Gastric Antral Vascular Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.43 ATP12A ATP4A
2 response to nutrient GO:0007584 9.4 OXCT1 SST
3 potassium ion import GO:0010107 9.37 ATP12A ATP4A
4 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
5 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Gastric Antral Vascular Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Gastric Antral Vascular Ectasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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