MCID: GST029
MIFTS: 31

Gastric Cardia Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Cardia Adenocarcinoma

MalaCards integrated aliases for Gastric Cardia Adenocarcinoma:

Name: Gastric Cardia Adenocarcinoma 12 15 73
Adenocarcinoma of Cardia of Stomach 12
Adenocarcinoma of Gastric Cardia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6271
NCIt 50 C5247
UMLS 73 C1333762

Summaries for Gastric Cardia Adenocarcinoma

MalaCards based summary : Gastric Cardia Adenocarcinoma, also known as adenocarcinoma of cardia of stomach, is related to esophageal cancer and squamous cell carcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Cardia Adenocarcinoma is HOTAIR (HOX Transcript Antisense RNA
T allele of rs12826786 was found to increase the risk of developing GCA and was associated with smoking habit and tumor-node-metastasis (TNM) stage. In addition,higher expression levels of HOTAIR were found in tumor tissues and rs12826786 SNP has a genotype-specific effect on HOTAIR expression.A high HOTAIR expression level was associated with poor GCA patients' survival.
Dysfunction Pattern: Regulation [up-regulated]), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Oxaliplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and lymph node.

Related Diseases for Gastric Cardia Adenocarcinoma

Diseases related to Gastric Cardia Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 esophageal cancer 32.5 C5orf66-AS1 H19 HOTAIR MEG3
2 squamous cell carcinoma 30.1 C5orf66-AS1 H19 HOTAIR LOC100130476
3 adenocarcinoma 10.9
4 functionless pituitary adenoma 10.7 HOTAIR MEG3
5 esophagus squamous cell carcinoma 10.6 HOTAIR MEG3
6 esophagitis 10.6
7 prostate disease 10.5 H19 MEG3
8 malignant glioma 10.4 H19 MEG3
9 pancreatic ductal adenocarcinoma 10.2 H19 HOTAIR
10 pituitary adenoma 10.2 H19 HOTAIR MEG3
11 ovarian epithelial cancer 10.2 H19 HOTAIR MEG3
12 kidney cancer 10.2 H19 HOTAIR MEG3
13 osteogenic sarcoma 10.2 H19 HOTAIR MEG3
14 gallbladder cancer 10.2 H19 HOTAIR MEG3
15 oral squamous cell carcinoma 10.1 H19 HOTAIR MEG3
16 thyroid cancer, nonmedullary, 1 10.1 H19 HOTAIR MEG3
17 osteoarthritis 10.1 H19 HOTAIR MEG3
18 adamantinoma of long bones 10.1 H19 HOTAIR MEG3
19 silver-russell syndrome 10.1 H19 MEG3
20 myeloma, multiple 10.1 H19 HOTAIR MEG3
21 helicobacter pylori infection 10.0
22 leukemia, chronic myeloid 10.0 H19 HOTAIR MEG3
23 lung cancer susceptibility 3 10.0 H19 HOTAIR MEG3
24 gastrointestinal system cancer 10.0 H19 HOTAIR
25 squamous cell carcinoma, head and neck 10.0 C5orf66-AS1 H19 HOTAIR
26 glioma 10.0 H19 HOTAIR MEG3
27 nasopharyngeal carcinoma 9.9 H19 HOTAIR MEG3
28 cervical cancer 9.9 H19 HOTAIR MEG3
29 gastric diffuse adenocarcinoma 9.9
30 aging 9.9
31 body mass index quantitative trait locus 1 9.9
32 glioblastoma 9.9 H19 HOTAIR MEG3
33 bladder cancer 9.7 C5orf66-AS1 H19 HOTAIR MEG3
34 melanoma 9.4 H19 HOTAIR MEG3

Graphical network of the top 20 diseases related to Gastric Cardia Adenocarcinoma:



Diseases related to Gastric Cardia Adenocarcinoma

Symptoms & Phenotypes for Gastric Cardia Adenocarcinoma

UMLS symptoms related to Gastric Cardia Adenocarcinoma:


abdominal pain, dyspepsia

Drugs & Therapeutics for Gastric Cardia Adenocarcinoma

Drugs for Gastric Cardia Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
2
Fluorouracil Approved Phase 2,Phase 1 51-21-8 3385
3
Carboplatin Approved Phase 1, Phase 2,Phase 2 41575-94-4 10339178 498142 38904
4
Paclitaxel Approved, Vet_approved Phase 1, Phase 2,Phase 2 33069-62-4 36314
5
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
6
Levoleucovorin Approved, Investigational Phase 1, Phase 2,Phase 2 68538-85-2
7
leucovorin Approved, Nutraceutical Phase 2,Phase 1 58-05-9 143 6006
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
9
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
10 Protein Kinase Inhibitors Phase 2
11 Micronutrients Phase 1, Phase 2
12 Albumin-Bound Paclitaxel Phase 1, Phase 2,Phase 2
13 Hematinics Phase 1, Phase 2
14 Trace Elements Phase 1, Phase 2
15 Vitamin B Complex Phase 1, Phase 2
16 Vitamins Phase 1, Phase 2
17 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
18 Antidotes Phase 1, Phase 2,Phase 2
19 Protective Agents Phase 1, Phase 2,Phase 2
20 Antimetabolites Phase 1, Phase 2,Phase 2
21 Bone Density Conservation Agents Phase 1, Phase 2
22 Antimetabolites, Antineoplastic Phase 1, Phase 2,Phase 2
23 Antimitotic Agents Phase 1, Phase 2,Phase 2
24 Calcium, Dietary Phase 1, Phase 2,Phase 2
25 Antineoplastic Agents, Phytogenic Phase 1, Phase 2,Phase 2
26 Folate Nutraceutical Phase 1, Phase 2
27 Vitamin B9 Nutraceutical Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Erlotinib and Chemotherapy for Unresectable or Metastatic Cancer of the Esophagus and Gastric Cardia Completed NCT00591123 Phase 2 FOLFOX and Erlotinib
2 Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery Recruiting NCT02730546 Phase 1, Phase 2 Carboplatin;Fluorouracil;Leucovorin Calcium;Oxaliplatin;Paclitaxel
3 FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma Recruiting NCT02037048 Phase 2 oxaliplatin;leucovorin calcium;fluorouracil;carboplatin;paclitaxel
4 Nodal Status in Adenocarcinoma of the Esophagus an Cardia Completed NCT01635595
5 Non-endoscopic EC Screening Program in Northern Iran Active, not recruiting NCT02311712 Not Applicable

Search NIH Clinical Center for Gastric Cardia Adenocarcinoma

Genetic Tests for Gastric Cardia Adenocarcinoma

Anatomical Context for Gastric Cardia Adenocarcinoma

MalaCards organs/tissues related to Gastric Cardia Adenocarcinoma:

41
Bone, T Cells, Lymph Node

Publications for Gastric Cardia Adenocarcinoma

Articles related to Gastric Cardia Adenocarcinoma:

(show top 50) (show all 84)
# Title Authors Year
1
MicroRNA-141 inhibits proliferation of gastric cardia adenocarcinoma by targeting MACC1. ( 29765447 )
2018
2
Aberrant methylation-mediated downregulation of long noncoding RNA C5orf66-AS1 promotes the development of gastric cardia adenocarcinoma. ( 29566283 )
2018
3
Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men. ( 29788475 )
2018
4
Postoperative Eyelid Metastasis of a Gastric Cardia Adenocarcinoma. ( 28469215 )
2017
5
Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma. ( 28345805 )
2017
6
A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA. ( 29040685 )
2017
7
Association of genotypes of rs671 withinALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas. ( 28443204 )
2017
8
CyclinD1 and p57<sup>kip2</sup>as biomarkers in differentiation, metastasis and prognosis of gastric cardia adenocarcinoma. ( 29088752 )
2017
9
Comparative analysis of gene expression profiles of gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma. ( 27895742 )
2016
10
Investigation of Cytotoxic T-lymphocyte antigen 4 Polymorphisms in Gastric Cardia Adenocarcinoma. ( 26709093 )
2016
11
Aberrant CpG Island Shore Region Methylation of CAV1 Is Associated with Tumor Progression and Poor Prognosis in Gastric Cardia Adenocarcinoma. ( 27986126 )
2016
12
Methylation-mediated downregulation of long noncoding RNA LOC100130476 in gastric cardia adenocarcinoma. ( 27189370 )
2016
13
CYR61 (CCN1) is a metastatic biomarker of gastric cardia adenocarcinoma. ( 27105510 )
2016
14
Gastric cardia adenocarcinoma microRNA profiling in Chinese patients. ( 26781873 )
2016
15
Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma. ( 27791400 )
2016
16
Clinicopathological features of Siewert type II adenocarcinoma: comparison of gastric cardia adenocarcinoma and Barrett's esophageal adenocarcinoma following endoscopic submucosal dissection. ( 27783167 )
2016
17
XPG Gene Polymorphisms and the Risk of Gastric Cardia Adenocarcinoma. ( 27228234 )
2016
18
Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation. ( 27384681 )
2016
19
FBXO32, aA new TGF-I^/Smad signaling pathway target gene, is epigenetically inactivated in gastric cardia adenocarcinoma. ( 25997968 )
2015
20
Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma. ( 26456015 )
2015
21
Programmed death-1 (PD-1) polymorphism is associated with gastric cardia adenocarcinoma. ( 26221374 )
2015
22
Correlation among RKIP expression, NF-I_B p65 levels, and T-lymphocyte subsets in gastric cardia adenocarcinoma. ( 26662448 )
2015
23
Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. ( 25476857 )
2015
24
RANK rs1805034 T&amp;gt;C Polymorphism Is Associated with Susceptibility to Gastric Cardia Adenocarcinoma in a Chinese Population. ( 26451891 )
2015
25
Down-regulation of C/EBP homologous protein (CHOP) expression in gastric cardia adenocarcinoma: Their relationship with clinicopathological parameters and prognostic significance. ( 25582300 )
2015
26
Esophageal Squamous Cell Carcinoma and Gastric Cardia Adenocarcinoma Shared Susceptibility Locus in C20orf54: Evidence from Published Studies. ( 26154995 )
2015
27
Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population. ( 26770518 )
2015
28
Variant TP53BP1 rs560191 G&amp;gt;C is associated with risk of gastric cardia adenocarcinoma in a Chinese Han population. ( 25937777 )
2015
29
Two distinct etiologies of gastric cardia adenocarcinoma: interactions among pH, Helicobacter pylori, and bile acids. ( 26029176 )
2015
30
Association between gastric cardia adenocarcinoma risk and alcohol flushing response, but not alcohol consumption. ( 24477652 )
2014
31
Identification of a novel gene fusion (BMX-ARHGAP) in gastric cardia adenocarcinoma. ( 25499959 )
2014
32
Microarray expression profile analysis of long non-coding RNAs of advanced stage human gastric cardia adenocarcinoma. ( 24414129 )
2014
33
Cutaneous metastasis of gastric cardia adenocarcinoma in a patient: a case report. ( 24753779 )
2014
34
Interleukin 17A rs3819024 A&amp;gt;G polymorphism is associated with an increased risk of gastric cardia adenocarcinoma in a Chinese population. ( 24893702 )
2014
35
Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi-institutional U.S. study. ( 25308915 )
2014
36
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis. ( 25395181 )
2014
37
Detection of autoantibodies to a panel of tumor-associated antigens for the diagnosis values of gastric cardia adenocarcinoma. ( 24612004 )
2014
38
Shorter dinner-to-bed time is associated with gastric cardia adenocarcinoma risk partly in a reflux-dependent manner. ( 24866433 )
2014
39
Obesity and related risk factors in gastric cardia adenocarcinoma. ( 25209115 )
2014
40
p21, p53, TP53BP1 and p73 polymorphisms and the risk of gastric cardia adenocarcinoma in a Chinese population. ( 25532599 )
2014
41
Decreased expression and aberrant methylation of RASSF5A correlates with malignant progression of gastric cardia adenocarcinoma. ( 25420558 )
2014
42
Esophageal squamous cell carcinoma and gastric cardia adenocarcinoma shared susceptibility locus in PLCE1: a meta-analysis. ( 23874915 )
2013
43
Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma. ( 23435833 )
2013
44
A meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma. ( 22898040 )
2013
45
Genetic and epigenetic alterations of WWOX in the development of gastric cardia adenocarcinoma. ( 23197378 )
2013
46
Despite shared susceptibility loci, esophageal squamous cell carcinoma embraces more familial cancer than gastric cardia adenocarcinoma in the Taihang Mountains high-risk region of northern central China. ( 23286478 )
2013
47
Gastric cardia adenocarcinoma pathway analysis. ( 24834279 )
2013
48
Expression of Das-1, Ki67 and sulfuric proteins in gastric cardia adenocarcinoma and intestinal metaplasia lesions. ( 23837030 )
2013
49
Aberrant methylation and loss expression of RKIP is associated with tumor progression and poor prognosis in gastric cardia adenocarcinoma. ( 22983529 )
2013
50
Methylation-mediated repression of GADD45A and GADD45G expression in gastric cardia adenocarcinoma. ( 23616123 )
2013

Variations for Gastric Cardia Adenocarcinoma

Expression for Gastric Cardia Adenocarcinoma

Search GEO for disease gene expression data for Gastric Cardia Adenocarcinoma.

Pathways for Gastric Cardia Adenocarcinoma

Pathways related to Gastric Cardia Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 HOTAIR MEG3

GO Terms for Gastric Cardia Adenocarcinoma

Sources for Gastric Cardia Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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