MCID: GST029
MIFTS: 29

Gastric Cardia Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Cardia Adenocarcinoma

MalaCards integrated aliases for Gastric Cardia Adenocarcinoma:

Name: Gastric Cardia Adenocarcinoma 12 15 71
Adenocarcinoma of Cardia of Stomach 12
Adenocarcinoma of Gastric Cardia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6271
NCIt 50 C5247
UMLS 71 C1333762

Summaries for Gastric Cardia Adenocarcinoma

MalaCards based summary : Gastric Cardia Adenocarcinoma, also known as adenocarcinoma of cardia of stomach, is related to esophageal cancer and cardia cancer, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Cardia Adenocarcinoma is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Levoleucovorin and Pembrolizumab have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and neutrophil.

Related Diseases for Gastric Cardia Adenocarcinoma

Diseases related to Gastric Cardia Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 esophageal cancer 31.5 SLC52A3 PLCE1 MTHFR MMP2 MIR203A MEG3
2 cardia cancer 30.7 SLC52A3 SEMA3B-AS1 PLCE1 MTHFR
3 adenocarcinoma 10.7
4 squamous cell carcinoma 10.4
5 helicobacter pylori infection 10.4
6 gastric adenocarcinoma 10.3
7 gastritis 10.3
8 lemierre's syndrome 10.3 MTHFR HOTAIR
9 functionless pituitary adenoma 10.3 MEG3 HOTAIR
10 gastroesophageal reflux 10.3
11 barrett esophagus 10.3
12 atrophic gastritis 10.3
13 esophagus squamous cell carcinoma 10.2 MEG3 HOTAIR
14 gastric cardia carcinoma 10.2 NEDD4 MTHFR
15 body mass index quantitative trait locus 1 10.2
16 ovarian epithelial cancer 10.1 MEG3 HOTAIR H19
17 thyroid cancer, nonmedullary, 1 10.1 MEG3 HOTAIR H19
18 laryngeal squamous cell carcinoma 10.1 MMP2 HOTAIR H19
19 hernia, hiatus 10.0
20 proteasome-associated autoinflammatory syndrome 1 10.0
21 gastrointestinal carcinoma 10.0
22 hyperuricemia 10.0
23 gastroesophageal junction adenocarcinoma 10.0
24 b-cell lymphoma 10.0
25 gallbladder cancer 10.0 MEG3 HOTAIR H19
26 osteogenic sarcoma 10.0 MMP2 MEG3 HOTAIR H19
27 high grade glioma 10.0 MEG3 HOTAIR H19
28 glioma 10.0 MMP2 MEG3 HOTAIR H19
29 pituitary adenoma 10.0 MEG3 HOTAIR H19 GADD45G
30 leukemia, chronic myeloid 9.9 MIR203A MEG3 HOTAIR H19
31 oral squamous cell carcinoma 9.9 MMP2 MIR203A MEG3 HOTAIR H19
32 nasopharyngeal carcinoma 9.8 MMP2 MEG3 HOTAIR H19
33 lung cancer susceptibility 3 9.8 MMP2 MEG3 HOTAIR H19
34 squamous cell carcinoma, head and neck 9.6 MMP2 HOTAIR H19 C5orf66-AS1
35 bladder cancer 9.6 MMP2 MIR203A MEG3 HOTAIR H19 C5orf66-AS1

Graphical network of the top 20 diseases related to Gastric Cardia Adenocarcinoma:



Diseases related to Gastric Cardia Adenocarcinoma

Symptoms & Phenotypes for Gastric Cardia Adenocarcinoma

UMLS symptoms related to Gastric Cardia Adenocarcinoma:


abdominal pain, dyspepsia

Drugs & Therapeutics for Gastric Cardia Adenocarcinoma

Drugs for Gastric Cardia Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2 149436
2
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
3
leucovorin Approved Phase 1, Phase 2 58-05-9 6006
4
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
5
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 5310940 9887054 6857599 43805
6
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
7
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
8
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
9 Nutrients Phase 1, Phase 2
10 Protective Agents Phase 1, Phase 2
11 Vitamin B Complex Phase 1, Phase 2
12 Micronutrients Phase 1, Phase 2
13 Hematinics Phase 1, Phase 2
14 Immunosuppressive Agents Phase 1, Phase 2
15 Antineoplastic Agents, Immunological Phase 1, Phase 2
16 Trace Elements Phase 1, Phase 2
17 Tubulin Modulators Phase 1, Phase 2
18 Albumin-Bound Paclitaxel Phase 1, Phase 2
19 Vitamins Phase 1, Phase 2
20 Immunologic Factors Phase 1, Phase 2
21 Antimetabolites Phase 1, Phase 2
22 Hormones Phase 1, Phase 2
23 Folate Phase 1, Phase 2
24 Antimitotic Agents Phase 1, Phase 2
25 Vitamin B9 Phase 1, Phase 2
26 Calcium, Dietary Phase 1, Phase 2
27 Antidotes Phase 1, Phase 2
28
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1b/2 Clinical Trial of Neoadjuvant Pembrolizumab Plus Concurrent Chemoradiotherapy With Weekly Carboplatin and Paclitaxel in Adult Patients With Resectable, Locally Advanced Adenocarcinoma of the Gastroesophageal Junction or Gastric Cardia Suspended NCT02730546 Phase 1, Phase 2 Carboplatin;Fluorouracil;Leucovorin Calcium;Oxaliplatin;Paclitaxel

Search NIH Clinical Center for Gastric Cardia Adenocarcinoma

Genetic Tests for Gastric Cardia Adenocarcinoma

Anatomical Context for Gastric Cardia Adenocarcinoma

MalaCards organs/tissues related to Gastric Cardia Adenocarcinoma:

40
Lymph Node, Endothelial, Neutrophil

Publications for Gastric Cardia Adenocarcinoma

Articles related to Gastric Cardia Adenocarcinoma:

(show top 50) (show all 283)
# Title Authors PMID Year
1
Long non-coding RNA ZFAS1 promotes the expression of EPAS1 in gastric cardia adenocarcinoma. 61
33364040 2021
2
miR-1262 suppresses gastric cardia adenocarcinoma via targeting oncogene ULK1. 61
33442421 2021
3
Trefoil factor 1 and gastrokine 2 inhibit Helicobacter pylori-induced proliferation and inflammation in gastric cardia and distal carcinogenesis. 61
33133254 2020
4
Long Non-coding RNA LINC01503 Promotes Gastric Cardia Adenocarcinoma Progression via miR-133a-5p/VIM Axis and EMT Process. 61
33200343 2020
5
Clinical profile of patients presenting with dysphagia - an experience from a tertiary care center in North India. 61
32514456 2020
6
Serum ghrelin and esophageal and gastric cancer in two cohorts in China. 61
31351006 2020
7
MiR-638 regulates gastric cardia adenocarcinoma cell proliferation, apoptosis, migration and invasion by targeting MACC1. 61
32064885 2020
8
Epigenetically silenced PD-L1 confers drug resistance to anti-PD1 therapy in gastric cardia adenocarcinoma. 61
32088639 2020
9
Gastric Cardia Adenocarcinoma with Metastasis to the Scalp: A Case Report. 61
32140341 2020
10
A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. 61
31897184 2020
11
Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma. 61
33194702 2020
12
Helicobacter pylori Is Associated With Precancerous and Cancerous Lesions of the Gastric Cardia Mucosa: Results of a Large Population-Based Study in China. 61
32195175 2020
13
Changing Disparity of Gastric Cancer Incidence by Histological Types in US Race-Specific Populations. 61
33297759 2020
14
A Comparison of Biopsy and Mucosal Swab Specimens for Examining the Microbiota of Upper Gastrointestinal Carcinoma. 61
31519703 2019
15
Serologic Profile of Antiparietal Cell Antibodies, Pepsinogens, and H. pylori and Risk of Upper Gastrointestinal Cancer: A Nested Case-Control Study in China. 61
31501152 2019
16
Interaction of 22 risk SNPs with Helicobacter pylori infection and risk of gastric cardia adenocarcinoma. 61
31650851 2019
17
[The association of Bcl-2 gene polymorphism with the esophageal cancer and gastric cardia adenocarcinoma in Hebei Province]. 61
31683398 2019
18
Microbial characterization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-risk region of China. 61
31355925 2019
19
Genetic variations associated with telomere length confer risk of gastric cardia adenocarcinoma. 61
30900102 2019
20
MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells. 61
31251699 2019
21
Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma. 61
30927083 2019
22
Overweight Patterns Between Childhood and Early Adulthood and Esophageal and Gastric Cardia Adenocarcinoma Risk. 61
31380608 2019
23
Mediterranean diet adherence and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. 61
30771119 2019
24
MiR-6872 host gene SEMA3B and its antisense lncRNA SEMA3B-AS1 function synergistically to suppress gastric cardia adenocarcinoma progression. 61
30656427 2019
25
Local and Systemic IL-7 Concentration in Gastrointestinal-Tract Cancers. 61
31185636 2019
26
Circumferential Endoscopic Submucosal Tunnel Dissection of Gastric Cardia Adenocarcinoma. 61
31620500 2019
27
Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997-2014. 61
29902641 2019
28
Hypoglycemia caused by co-secretion of insulin from lung tumor and cardia cancer: first case report. 61
29166433 2019
29
The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma. 61
30976198 2019
30
Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men. 61
29788475 2019
31
Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma: A 16-year prospective analysis from the NIH-AARP diet and health cohort. 61
29992560 2018
32
Tree nut, peanut, and peanut butter consumption and the risk of gastric and esophageal cancer subtypes: the Netherlands Cohort Study. 61
29594821 2018
33
Leukocyte telomere length and risk of gastric cardia adenocarcinoma. 61
30275518 2018
34
Aberrant methylation-mediated downregulation of long noncoding RNA C5orf66-AS1 promotes the development of gastric cardia adenocarcinoma. 61
29566283 2018
35
Periurethral Mass Mimicking Neoplasm After Injection of Macroplastique for Postprostatectomy Stress Incontinence: A Pitfall on 18F-FDG PET/CT. 61
29517541 2018
36
MicroRNA-141 inhibits proliferation of gastric cardia adenocarcinoma by targeting MACC1. 61
29765447 2018
37
Five serum-based miRNAs were identified as potential diagnostic biomarkers in gastric cardia adenocarcinoma. 61
30198863 2018
38
A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA. 61
29040685 2017
39
Association of high-evidence gastric cancer susceptibility loci and somatic gene expression levels with survival. 61
29028942 2017
40
Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes. 61
28768652 2017
41
CyclinD1 and p57kip2 as biomarkers in differentiation, metastasis and prognosis of gastric cardia adenocarcinoma. 61
29088752 2017
42
Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma. 61
28345805 2017
43
Body mass index and risk of gastric cancer: A 30-year follow-up study in the Linxian general population trial cohort. 61
28594442 2017
44
Clinicopathological features of Siewert type II adenocarcinoma: comparison of gastric cardia adenocarcinoma and Barrett's esophageal adenocarcinoma following endoscopic submucosal dissection. 61
27783167 2017
45
Gastric microbiota features associated with cancer risk factors and clinical outcomes: A pilot study in gastric cardia cancer patients from Shanxi, China. 61
28319273 2017
46
Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies. 61
28336766 2017
47
Red and processed meat consumption and gastric cancer risk: a systematic review and meta-analysis. 61
28430644 2017
48
Postoperative Eyelid Metastasis of a Gastric Cardia Adenocarcinoma. 61
28469215 2017
49
Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies. 61
28196067 2017
50
Association of genotypes of rs671 withinALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas. 61
28443204 2017

Variations for Gastric Cardia Adenocarcinoma

Expression for Gastric Cardia Adenocarcinoma

Search GEO for disease gene expression data for Gastric Cardia Adenocarcinoma.

Pathways for Gastric Cardia Adenocarcinoma

Pathways related to Gastric Cardia Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 MEG3 HOTAIR

GO Terms for Gastric Cardia Adenocarcinoma

Sources for Gastric Cardia Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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