MCID: GST029
MIFTS: 31

Gastric Cardia Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Cardia Adenocarcinoma

MalaCards integrated aliases for Gastric Cardia Adenocarcinoma:

Name: Gastric Cardia Adenocarcinoma 12 15 71
Adenocarcinoma of Cardia of Stomach 12
Adenocarcinoma of Gastric Cardia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6271
NCIt 49 C5247
UMLS 71 C1333762

Summaries for Gastric Cardia Adenocarcinoma

MalaCards based summary : Gastric Cardia Adenocarcinoma, also known as adenocarcinoma of cardia of stomach, is related to esophageal cancer and cardia cancer, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Cardia Adenocarcinoma is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Trioxsalen and Dihematoporphyrin Ether have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone and lung.

Related Diseases for Gastric Cardia Adenocarcinoma

Diseases related to Gastric Cardia Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 esophageal cancer 32.2 TP53 SLC52A3 PLCE1 MTHFR MIR203A MEG3
2 cardia cancer 30.1 TP53 SLC52A3 SEMA3B-AS1 PLCE1 MTHFR MIR770
3 adenocarcinoma 11.0
4 helicobacter pylori infection 10.4
5 squamous cell carcinoma 10.4
6 lemierre's syndrome 10.4 MTHFR HOTAIR
7 functionless pituitary adenoma 10.3 MEG3 HOTAIR
8 barrett esophagus 10.3
9 gastric adenocarcinoma 10.3
10 gastritis 10.3
11 pregnancy loss, recurrent 1 10.3 MTHFR HOTAIR
12 gastric cardia carcinoma 10.3 NEDD4 MTHFR
13 gastroesophageal reflux 10.3
14 atrophic gastritis 10.3
15 marek disease 10.2 TP53 H19
16 thyroid cancer, nonmedullary, 1 10.2 MEG3 HOTAIR H19
17 body mass index quantitative trait locus 1 10.2
18 gastric cancer 10.2
19 esophagus squamous cell carcinoma 10.1 MEG3 HOTAIR
20 vulva squamous cell carcinoma 10.1 TP53 MEG3
21 wilms tumor predisposition 10.0 TP53 H19
22 hernia, hiatus 10.0
23 lung cancer 10.0
24 proteasome-associated autoinflammatory syndrome 1 10.0
25 body mass index quantitative trait locus 11 10.0
26 body mass index quantitative trait locus 9 10.0
27 body mass index quantitative trait locus 8 10.0
28 body mass index quantitative trait locus 4 10.0
29 body mass index quantitative trait locus 10 10.0
30 body mass index quantitative trait locus 7 10.0
31 body mass index quantitative trait locus 12 10.0
32 body mass index quantitative trait locus 14 10.0
33 body mass index quantitative trait locus 18 10.0
34 body mass index quantitative trait locus 19 10.0
35 body mass index quantitative trait locus 20 10.0
36 gastrointestinal carcinoma 10.0
37 hyperuricemia 10.0
38 palmoplantar keratosis 10.0
39 gastroesophageal junction adenocarcinoma 10.0
40 b-cell lymphoma 10.0
41 retinoblastoma 10.0
42 familial retinoblastoma 10.0
43 pituitary adenoma 10.0 MEG3 HOTAIR H19 GADD45G
44 glioma susceptibility 1 10.0 TP53 MEG3 HOTAIR H19
45 glioma 10.0 TP53 MEG3 HOTAIR H19
46 malignant glioma 9.9 TP53 MEG3 HOTAIR H19
47 laryngeal squamous cell carcinoma 9.9 TP53 HOTAIR H19
48 gallbladder cancer 9.9 TP53 MEG3 HOTAIR H19
49 pancreatic ductal adenocarcinoma 9.9 TP53 MIR203A HOTAIR H19
50 pituitary carcinoma 9.9 TP53 MEG3

Graphical network of the top 20 diseases related to Gastric Cardia Adenocarcinoma:



Diseases related to Gastric Cardia Adenocarcinoma

Symptoms & Phenotypes for Gastric Cardia Adenocarcinoma

UMLS symptoms related to Gastric Cardia Adenocarcinoma:


abdominal pain, dyspepsia

Drugs & Therapeutics for Gastric Cardia Adenocarcinoma

Drugs for Gastric Cardia Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trioxsalen Approved Phase 3 3902-71-4 5585
2 Dihematoporphyrin Ether Phase 3
3 Photosensitizing Agents Phase 3
4 Hematoporphyrins Phase 3
5 Dermatologic Agents Phase 3
6 Hematoporphyrin Derivative Phase 3
7 Ether Phase 3
8
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
9
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
10
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
11
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
12
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
13
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 43805 6857599 5310940 9887054
14
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2
15
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
16
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
17
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
18
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
19 Protein Kinase Inhibitors Phase 2
20
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
21 Micronutrients Phase 1, Phase 2
22 Trace Elements Phase 1, Phase 2
23 Vitamins Phase 1, Phase 2
24 Antidotes Phase 1, Phase 2
25 Vitamin B Complex Phase 1, Phase 2
26 Nutrients Phase 1, Phase 2
27 Folate Phase 1, Phase 2
28 Protective Agents Phase 1, Phase 2
29 Vitamin B9 Phase 1, Phase 2
30 Immunologic Factors Phase 1, Phase 2
31 Albumin-Bound Paclitaxel Phase 1, Phase 2
32 Hormones Phase 1, Phase 2
33 Hematinics Phase 1, Phase 2
34 Immunosuppressive Agents Phase 1, Phase 2
35 Tubulin Modulators Phase 1, Phase 2
36 Calcium, Dietary Phase 1, Phase 2
37 Antimitotic Agents Phase 1, Phase 2
38 Antimetabolites Phase 1, Phase 2
39 Antineoplastic Agents, Immunological Phase 1, Phase 2
40
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Two-arm Phase III Trial Comparing Different Time of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer Unknown status NCT02628665 Phase 3 photosensitizer(photofrin)
2 A Phase II, Open-Label Study Evaluating Clinical Efficacy, Safety, Pharmacokinetic and Pharmacodynamic Effects of Lapatinib (GW572016) in Patients With Relapsed Adenocarcinoma of the Esophagus, Including Tumors of the Gastroesophageal Junction and Gastric Cardia Completed NCT00259987 Phase 2 Lapatinib (GW572016) oral tablets
3 A Phase II Study of Erlotinib and Modified FOLFOX-6 (5-Fluorouracil, Leucovorin and Oxaliplatin) in Previously Untreated Patients With Unresectable or Metastatic Adenocarcinoma of the Esophagus and Gastric Cardia Completed NCT00591123 Phase 2 FOLFOX and Erlotinib
4 Randomized Phase II Trial of Extended Neoadjuvant Therapy for Locally Advanced Adenocarcinoma of the Esophagus, Gastroesophageal Junction, and Gastric Cardia Completed NCT00938470 Phase 2 capecitabine;docetaxel;fluorouracil;oxaliplatin
5 Phase 1b/2 Clinical Trial of Neoadjuvant Pembrolizumab Plus Concurrent Chemoradiotherapy With Weekly Carboplatin and Paclitaxel in Adult Patients With Resectable, Locally Advanced Adenocarcinoma of the Gastroesophageal Junction or Gastric Cardia Recruiting NCT02730546 Phase 1, Phase 2 Carboplatin;Fluorouracil;Leucovorin Calcium;Oxaliplatin;Paclitaxel
6 A Phase II Trial of Modified FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Response Based Concurrent Chemoradiotherapy in Patients With Locoregionally Advanced Adenocarcinoma of the Esophagus, Gastro-esophageal Junction, and Gastric Cardia Recruiting NCT02037048 Phase 2 oxaliplatin;leucovorin calcium;fluorouracil;carboplatin;paclitaxel
7 Prevalence of Dysplasia of the Gastric Cardia Completed NCT01787864

Search NIH Clinical Center for Gastric Cardia Adenocarcinoma

Genetic Tests for Gastric Cardia Adenocarcinoma

Anatomical Context for Gastric Cardia Adenocarcinoma

MalaCards organs/tissues related to Gastric Cardia Adenocarcinoma:

40
Lymph Node, Bone, Lung, T Cells, Endothelial, Neutrophil

Publications for Gastric Cardia Adenocarcinoma

Articles related to Gastric Cardia Adenocarcinoma:

(show top 50) (show all 281)
# Title Authors PMID Year
1
Clinical profile of patients presenting with dysphagia - an experience from a tertiary care center in North India. 61
32514456 2020
2
Serum ghrelin and esophageal and gastric cancer in two cohorts in China. 61
31351006 2020
3
MiR-638 regulates gastric cardia adenocarcinoma cell proliferation, apoptosis, migration and invasion by targeting MACC1. 61
32064885 2020
4
Epigenetically silenced PD-L1 confers drug resistance to anti-PD1 therapy in gastric cardia adenocarcinoma. 61
32088639 2020
5
Gastric Cardia Adenocarcinoma with Metastasis to the Scalp: A Case Report. 61
32140341 2020
6
A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. 61
31897184 2020
7
Helicobacter pylori Is Associated With Precancerous and Cancerous Lesions of the Gastric Cardia Mucosa: Results of a Large Population-Based Study in China. 61
32195175 2020
8
Serologic Profile of Antiparietal Cell Antibodies, Pepsinogens, and H. pylori and Risk of Upper Gastrointestinal Cancer: A Nested Case-Control Study in China. 61
31501152 2019
9
A Comparison of Biopsy and Mucosal Swab Specimens for Examining the Microbiota of Upper Gastrointestinal Carcinoma. 61
31519703 2019
10
Microbial characterization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-risk region of China. 61
31355925 2019
11
Interaction of 22 risk SNPs with Helicobacter pylori infection and risk of gastric cardia adenocarcinoma. 61
31650851 2019
12
[The association of Bcl-2 gene polymorphism with the esophageal cancer and gastric cardia adenocarcinoma in Hebei Province]. 61
31683398 2019
13
Genetic variations associated with telomere length confer risk of gastric cardia adenocarcinoma. 61
30900102 2019
14
MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells. 61
31251699 2019
15
Overweight Patterns Between Childhood and Early Adulthood and Esophageal and Gastric Cardia Adenocarcinoma Risk. 61
31380608 2019
16
Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma. 61
30927083 2019
17
Mediterranean diet adherence and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. 61
30771119 2019
18
MiR-6872 host gene SEMA3B and its antisense lncRNA SEMA3B-AS1 function synergistically to suppress gastric cardia adenocarcinoma progression. 61
30656427 2019
19
Local and Systemic IL-7 Concentration in Gastrointestinal-Tract Cancers. 61
31185636 2019
20
Circumferential Endoscopic Submucosal Tunnel Dissection of Gastric Cardia Adenocarcinoma. 61
31620500 2019
21
Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997-2014. 61
29902641 2019
22
Hypoglycemia caused by co-secretion of insulin from lung tumor and cardia cancer: first case report. 61
29166433 2019
23
Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men. 61
29788475 2019
24
The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma. 61
30976198 2019
25
Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma: A 16-year prospective analysis from the NIH-AARP diet and health cohort. 61
29992560 2018
26
Tree nut, peanut, and peanut butter consumption and the risk of gastric and esophageal cancer subtypes: the Netherlands Cohort Study. 61
29594821 2018
27
Leukocyte telomere length and risk of gastric cardia adenocarcinoma. 61
30275518 2018
28
Aberrant methylation-mediated downregulation of long noncoding RNA C5orf66-AS1 promotes the development of gastric cardia adenocarcinoma. 61
29566283 2018
29
Periurethral Mass Mimicking Neoplasm After Injection of Macroplastique for Postprostatectomy Stress Incontinence: A Pitfall on 18F-FDG PET/CT. 61
29517541 2018
30
MicroRNA-141 inhibits proliferation of gastric cardia adenocarcinoma by targeting MACC1. 61
29765447 2018
31
Five serum-based miRNAs were identified as potential diagnostic biomarkers in gastric cardia adenocarcinoma. 61
30198863 2018
32
A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA. 61
29040685 2017
33
Expression of TGF-b and CD-44 in age specific subgroup of patients with adenocarcinoma of gastric cardia. 61
31952750 2017
34
Association of high-evidence gastric cancer susceptibility loci and somatic gene expression levels with survival. 61
29028942 2017
35
Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes. 61
28768652 2017
36
CyclinD1 and p57kip2 as biomarkers in differentiation, metastasis and prognosis of gastric cardia adenocarcinoma. 61
29088752 2017
37
Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma. 61
28345805 2017
38
Body mass index and risk of gastric cancer: A 30-year follow-up study in the Linxian general population trial cohort. 61
28594442 2017
39
Gastric microbiota features associated with cancer risk factors and clinical outcomes: A pilot study in gastric cardia cancer patients from Shanxi, China. 61
28319273 2017
40
Clinicopathological features of Siewert type II adenocarcinoma: comparison of gastric cardia adenocarcinoma and Barrett's esophageal adenocarcinoma following endoscopic submucosal dissection. 61
27783167 2017
41
Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies. 61
28336766 2017
42
Impact of TGF-b and CD-44 for the benefit of radical surgery in elderly patients with adenocarcinoma of gastric cardia. 61
32135922 2017
43
Postoperative Eyelid Metastasis of a Gastric Cardia Adenocarcinoma. 61
28469215 2017
44
Red and processed meat consumption and gastric cancer risk: a systematic review and meta-analysis. 61
28430644 2017
45
Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies. 61
28196067 2017
46
Association of genotypes of rs671 withinALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas. 61
28443204 2017
47
Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population. 61
28367233 2017
48
Adenocarcinoma risk in patients registered with Polish Barrett's Oesophagus Registry. 61
27377059 2017
49
Comparative analysis of gene expression profiles of gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma. 61
27895742 2016
50
Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma. 61
27791400 2016

Variations for Gastric Cardia Adenocarcinoma

Expression for Gastric Cardia Adenocarcinoma

Search GEO for disease gene expression data for Gastric Cardia Adenocarcinoma.

Pathways for Gastric Cardia Adenocarcinoma

Pathways related to Gastric Cardia Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.88 TP53 MEG3 HOTAIR

GO Terms for Gastric Cardia Adenocarcinoma

Sources for Gastric Cardia Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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