MCID: GST041
MIFTS: 32

Gastric Cardia Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Cardia Carcinoma

MalaCards integrated aliases for Gastric Cardia Carcinoma:

Name: Gastric Cardia Carcinoma 12 15 73
Carcinoma of Cardia of Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6270
NCIt 50 C6794
UMLS 73 C1333763

Summaries for Gastric Cardia Carcinoma

MalaCards based summary : Gastric Cardia Carcinoma, also known as carcinoma of cardia of stomach, is related to gastrointestinal stromal tumor and esophageal adenosquamous carcinoma. An important gene associated with Gastric Cardia Carcinoma is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Adhesion. The drugs Capecitabine and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and liver, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Gastric Cardia Carcinoma

Diseases related to Gastric Cardia Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 gastrointestinal stromal tumor 29.2 ANO1 CD44 CHGA KIT MTHFR
2 esophageal adenosquamous carcinoma 10.3 CDH1 WWOX
3 goblet cell carcinoid 10.2 CDH1 CHGA
4 hemifacial spasm 10.2 MTHFR TYMS
5 biphasic synovial sarcoma 10.2 CDH1 MUC1
6 urethral benign neoplasm 10.2 CHGA SMAD4
7 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA MUC1
8 chordoid meningioma 10.2 CHGA MUC1
9 clear cell meningioma 10.1 CHGA MUC1
10 lobular neoplasia 10.1 CDH1 MUC1
11 lymphoepithelioma-like carcinoma 10.1 CDH1 MUC1
12 pancreatoblastoma 10.1 CHGA MUC1
13 esophagus sarcoma 10.1 KIT WWOX
14 acinar cell cystadenocarcinoma 10.1 CHGA MUC5AC
15 gastrointestinal neuroendocrine tumor 10.1 CD44 CHGA
16 mucositis 10.1 MTHFR TYMS XRCC1
17 suppression of tumorigenicity 12 10.1 CDH1 CHGA SMAD4
18 breast mucoepidermoid carcinoma 10.1 MUC1 MUC5AC
19 solid adenocarcinoma with mucin production 10.1 MUC1 MUC5AC
20 tubular adenocarcinoma 10.1 CDH1 CHGA MUC1
21 signet ring cell adenocarcinoma 10.1 CDH1 CHGA MUC1
22 bile duct mucoepidermoid carcinoma 10.1 MUC1 MUC5AC
23 chronic ethmoiditis 10.1 MUC1 MUC5AC
24 intestinal disease 10.1 CDH1 TLR4 TYMS
25 bile duct cystadenocarcinoma 10.1 MUC1 MUC5AC
26 reticular perineurioma 10.1 KIT MUC1
27 perineurioma 10.1 KIT MUC1
28 chondroid chordoma 10.1 CDH1 MUC1
29 nondisjunction 10.1 KIT MTHFR
30 mixed ductal-endocrine carcinoma 10.1 CHGA MUC1 SMAD4
31 sclerosing hemangioma 10.1 CHGA MUC1
32 mucinous ovarian cystadenoma 10.1 MUC1 MUC5AC
33 filamentary keratitis 10.0 MUC1 MUC5AC
34 testicular infarct 10.0 KIT MTHFR
35 biliary papillomatosis 10.0 MUC1 MUC5AC
36 aggressive digital papillary adenocarcinoma 10.0 KIT MUC1
37 ethmoid sinusitis 10.0 MUC1 MUC5AC
38 bile duct adenocarcinoma 10.0 CDH1 MUC1 MUC5AC
39 cardia cancer 10.0 MTHFR TYMS WWOX XRCC1
40 perivascular epithelioid cell tumor 10.0 KIT MUC1
41 intrahepatic cholangiocarcinoma 10.0 CDH1 MUC1 MUC5AC
42 dental abscess 10.0 KIT TLR4
43 prostate leiomyosarcoma 10.0 CD44 KIT
44 limbal stem cell deficiency 10.0 MUC1 MUC5AC
45 colloid carcinoma of the pancreas 10.0 MUC1 MUC5AC SMAD4
46 respiratory system disease 10.0 CDH1 MUC5AC TLR4
47 sarcomatoid renal cell carcinoma 10.0 CDH1 KIT MUC1
48 gastric tubular adenocarcinoma 10.0 CHGA MUC1 MUC5AC
49 sarcoma, synovial 10.0 CDH1 KIT MUC1
50 mucoepidermoid carcinoma 10.0 CHGA MUC1 MUC5AC

Graphical network of the top 20 diseases related to Gastric Cardia Carcinoma:



Diseases related to Gastric Cardia Carcinoma

Symptoms & Phenotypes for Gastric Cardia Carcinoma

GenomeRNAi Phenotypes related to Gastric Cardia Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CD44 CDH1 CHGA MUC5AC SMAD4 TYMS

MGI Mouse Phenotypes related to Gastric Cardia Carcinoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ANO1 CD44 CDH1 CHGA KISS1 KIT
2 growth/size/body region MP:0005378 10.25 ANO1 CD44 CDH1 CHGA KISS1 KIT
3 mortality/aging MP:0010768 10.17 ANO1 CD44 CDH1 CHGA KISS1 KIT
4 digestive/alimentary MP:0005381 10.14 ANO1 CD44 CDH1 KISS1 KIT MUC5AC
5 integument MP:0010771 10.08 ANO1 CD44 CDH1 KISS1 KIT MTHFR
6 endocrine/exocrine gland MP:0005379 10.07 CD44 CDH1 CHGA KISS1 KIT SMAD4
7 nervous system MP:0003631 10.02 ANO1 CD44 CHGA KISS1 KIT MTHFR
8 liver/biliary system MP:0005370 10 CD44 KISS1 KIT MTHFR SMAD4 TLR4
9 neoplasm MP:0002006 9.91 CD44 CDH1 KIT SMAD4 TLR4 WWOX
10 muscle MP:0005369 9.88 ANO1 CD44 CHGA KIT SMAD4 TLR4
11 no phenotypic analysis MP:0003012 9.73 CDH1 CHGA KISS1 KIT MTHFR WWOX
12 renal/urinary system MP:0005367 9.7 ANO1 CD44 CHGA KISS1 KIT SMAD4
13 reproductive system MP:0005389 9.61 CD44 CDH1 CHGA KISS1 KIT MTHFR
14 skeleton MP:0005390 9.17 ANO1 CD44 KIT MTHFR SMAD4 TLR4

Drugs & Therapeutics for Gastric Cardia Carcinoma

Drugs for Gastric Cardia Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
2
Docetaxel Approved, Investigational Phase 1, Phase 2 114977-28-5 148124
3
leucovorin Approved Phase 1, Phase 2,Phase 2 58-05-9 6006 143
4
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2
5
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
6
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
7
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
8
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 43805 6857599 5310940 9887054
9
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
11 Antimetabolites Phase 1, Phase 2,Phase 2
12 Antimetabolites, Antineoplastic Phase 1, Phase 2,Phase 2
13 Antimitotic Agents Phase 1, Phase 2,Phase 2
14 Micronutrients Phase 1, Phase 2,Not Applicable
15 Trace Elements Phase 1, Phase 2,Not Applicable
16 Bone Density Conservation Agents Phase 1, Phase 2
17 Vitamin B9 Phase 1, Phase 2
18 Immunosuppressive Agents Phase 1, Phase 2
19 Immunologic Factors Phase 1, Phase 2
20 Vitamins Phase 1, Phase 2
21 Calcium, Dietary Phase 1, Phase 2
22 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
23 Albumin-Bound Paclitaxel Phase 1, Phase 2
24 Hematinics Phase 1, Phase 2
25 Folate Phase 1, Phase 2
26 Protective Agents Phase 1, Phase 2
27 Vitamin B Complex Phase 1, Phase 2
28 Antidotes Phase 1, Phase 2
29
Iodine Approved, Investigational Not Applicable 7553-56-2 807
30 cadexomer iodine Not Applicable
31 Anti-Infective Agents Not Applicable
32 Anti-Infective Agents, Local Not Applicable
33 Lugol's solution Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 TaxXel: Taxotere and Xeloda in Esophageal Cancer Unknown status NCT00821912 Phase 1, Phase 2 Docetaxel;Capecitabine
2 Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery Recruiting NCT02730546 Phase 1, Phase 2 Carboplatin;Fluorouracil;Leucovorin Calcium;Oxaliplatin;Paclitaxel
3 Endoscopic Screening on Esophageal Cancer Completed NCT02094105 Not Applicable
4 Esophageal Cancer Genetics Studies Recruiting NCT00341276

Search NIH Clinical Center for Gastric Cardia Carcinoma

Genetic Tests for Gastric Cardia Carcinoma

Anatomical Context for Gastric Cardia Carcinoma

MalaCards organs/tissues related to Gastric Cardia Carcinoma:

41
Lung, Skin, Liver, Ovary, Prostate, Pancreas, Small Intestine

Publications for Gastric Cardia Carcinoma

Articles related to Gastric Cardia Carcinoma:

# Title Authors Year
1
Gastric cardia carcinoma is associated with the promoter -77T>C gene polymorphism of X-ray cross-complementing group 1 (XRCC1). ( 19662459 )
2009
2
[Expression and clinical significance of KiSS-1 and E-cadherin in gastric cardia carcinoma]. ( 17659469 )
2007
3
Infusional chemotherapy and cyclic radiation therapy in inoperable esophageal and gastric cardia carcinoma. ( 6829494 )
1983
4
MODIFICATIONS IN THE ORGANISM FOLLOWING REMOVAL OF GASTRIC CARDIA CARCINOMA AND METHODS OF THEIR COMPENSATION. ( 14103916 )
1963

Variations for Gastric Cardia Carcinoma

Expression for Gastric Cardia Carcinoma

Search GEO for disease gene expression data for Gastric Cardia Carcinoma.

Pathways for Gastric Cardia Carcinoma

Pathways related to Gastric Cardia Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.55 CDH1 SMAD4 TLR4
2 10.89 CD44 CDH1 MUC1
3 10.21 CDH1 SMAD4

GO Terms for Gastric Cardia Carcinoma

Cellular components related to Gastric Cardia Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell granule GO:0042629 8.96 CHGA KIT
2 apical plasma membrane GO:0016324 8.92 ANO1 CD44 KISS1 MUC1

Biological processes related to Gastric Cardia Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.71 CDH1 MTHFR TYMS XRCC1
2 response to hypoxia GO:0001666 9.65 MTHFR SMAD4 XRCC1
3 developmental growth GO:0048589 9.49 SMAD4 TYMS
4 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.46 CD44 MUC1
5 mast cell degranulation GO:0043303 9.43 CHGA KIT
6 tetrahydrofolate interconversion GO:0035999 9.37 MTHFR TYMS
7 tetrahydrofolate metabolic process GO:0046653 9.32 MTHFR TYMS
8 response to folic acid GO:0051593 9.26 MTHFR TYMS
9 mast cell chemotaxis GO:0002551 9.16 CHGA KIT
10 positive regulation of luteinizing hormone secretion GO:0033686 8.96 KISS1 SMAD4
11 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Gastric Cardia Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cofactor binding GO:0048037 8.62 TYMS WWOX

Sources for Gastric Cardia Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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