MCID: GST041
MIFTS: 27

Gastric Cardia Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Cardia Carcinoma

MalaCards integrated aliases for Gastric Cardia Carcinoma:

Name: Gastric Cardia Carcinoma 12 15 73
Carcinoma of Cardia of Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6270
NCIt 50 C6794
UMLS 73 C1333763

Summaries for Gastric Cardia Carcinoma

MalaCards based summary : Gastric Cardia Carcinoma, also known as carcinoma of cardia of stomach, is related to squamous cell carcinoma and esophageal adenosquamous carcinoma. An important gene associated with Gastric Cardia Carcinoma is XRCC1 (X-Ray Repair Cross Complementing 1). The drugs Capecitabine and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Gastric Cardia Carcinoma

Diseases related to Gastric Cardia Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.4 CDH1 WWOX XRCC1
2 esophageal adenosquamous carcinoma 10.4 CDH1 WWOX
3 esophagitis 10.1
4 squamous cell papilloma 10.1 ELP1 WWOX
5 gastrointestinal system benign neoplasm 10.0 CDH1 MTHFR
6 intestinal benign neoplasm 10.0 CDH1 MTHFR
7 riboflavin deficiency 9.9 MTHFR SLC52A3
8 mucositis 9.9 MTHFR XRCC1
9 gastrointestinal stromal tumor 9.9
10 cleft lip/palate 9.7 CDH1 MTHFR
11 differentiated thyroid carcinoma 9.5 MTHFR XRCC1
12 esophageal cancer 9.4 CDH1 PLCE1 SLC52A3 WWOX

Graphical network of the top 20 diseases related to Gastric Cardia Carcinoma:



Diseases related to Gastric Cardia Carcinoma

Symptoms & Phenotypes for Gastric Cardia Carcinoma

MGI Mouse Phenotypes related to Gastric Cardia Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.92 PLCE1 SLC52A3 WWOX XRCC1 CDH1 ELP1
2 growth/size/body region MP:0005378 9.91 CDH1 ELP1 KISS1 MTHFR SLC52A3 WWOX
3 mortality/aging MP:0010768 9.76 CDH1 ELP1 KISS1 MAD1L1 MTHFR SLC52A3
4 integument MP:0010771 9.65 CDH1 ELP1 KISS1 MTHFR SLC52A3
5 neoplasm MP:0002006 9.35 CDH1 MAD1L1 PLCE1 WWOX XRCC1
6 no phenotypic analysis MP:0003012 9.1 CDH1 ELP1 KISS1 MAD1L1 MTHFR WWOX

Drugs & Therapeutics for Gastric Cardia Carcinoma

Drugs for Gastric Cardia Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
2
Docetaxel Approved, Investigational Phase 1, Phase 2 114977-28-5 148124
3
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
4
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 5310940 9887054 43805 6857599
5
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
6
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
7
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
8
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2
9
leucovorin Approved, Nutraceutical Phase 1, Phase 2,Phase 2 58-05-9 143 6006
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
11 Antimetabolites Phase 1, Phase 2,Phase 2
12 Antimetabolites, Antineoplastic Phase 1, Phase 2,Phase 2
13 Antimitotic Agents Phase 1, Phase 2,Phase 2
14 Micronutrients Phase 1, Phase 2,Not Applicable
15 Trace Elements Phase 1, Phase 2,Not Applicable
16 Albumin-Bound Paclitaxel Phase 1, Phase 2
17 Hematinics Phase 1, Phase 2
18 Vitamin B Complex Phase 1, Phase 2
19 Vitamins Phase 1, Phase 2
20 Immunosuppressive Agents Phase 1, Phase 2
21 Antidotes Phase 1, Phase 2
22 Protective Agents Phase 1, Phase 2
23 Bone Density Conservation Agents Phase 1, Phase 2
24 Calcium, Dietary Phase 1, Phase 2
25 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
26 Folate Nutraceutical Phase 1, Phase 2
27 Vitamin B9 Nutraceutical Phase 1, Phase 2
28
Iodine Approved, Investigational Not Applicable 7553-56-2 807
29 cadexomer iodine Not Applicable
30 Anti-Infective Agents Not Applicable
31 Anti-Infective Agents, Local Not Applicable
32 Lugol's solution Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 TaxXel: Taxotere and Xeloda in Esophageal Cancer Unknown status NCT00821912 Phase 1, Phase 2 Docetaxel;Capecitabine
2 Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery Recruiting NCT02730546 Phase 1, Phase 2 Carboplatin;Fluorouracil;Leucovorin Calcium;Oxaliplatin;Paclitaxel
3 Endoscopic Screening on Esophageal Cancer Completed NCT02094105 Not Applicable
4 Esophageal Cancer Genetics Studies Recruiting NCT00341276

Search NIH Clinical Center for Gastric Cardia Carcinoma

Genetic Tests for Gastric Cardia Carcinoma

Anatomical Context for Gastric Cardia Carcinoma

MalaCards organs/tissues related to Gastric Cardia Carcinoma:

41
Bone

Publications for Gastric Cardia Carcinoma

Articles related to Gastric Cardia Carcinoma:

# Title Authors Year
1
Coexistence of gastrointestinal stromal tumor, esophageal and gastric cardia carcinomas. ( 23569349 )
2013
2
Gastric cardia carcinoma is associated with the promoter -77T>C gene polymorphism of X-ray cross-complementing group 1 (XRCC1). ( 19662459 )
2009
3
Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas. ( 18197935 )
2008
4
[Expression and clinical significance of KiSS-1 and E-cadherin in gastric cardia carcinoma]. ( 17659469 )
2007
5
Infusional chemotherapy and cyclic radiation therapy in inoperable esophageal and gastric cardia carcinoma. ( 6829494 )
1983
6
MODIFICATIONS IN THE ORGANISM FOLLOWING REMOVAL OF GASTRIC CARDIA CARCINOMA AND METHODS OF THEIR COMPENSATION. ( 14103916 )
1963

Variations for Gastric Cardia Carcinoma

Expression for Gastric Cardia Carcinoma

Search GEO for disease gene expression data for Gastric Cardia Carcinoma.

Pathways for Gastric Cardia Carcinoma

GO Terms for Gastric Cardia Carcinoma

Biological processes related to Gastric Cardia Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.13 CDH1 MTHFR XRCC1
2 regulation of protein kinase activity GO:0045859 8.62 ELP1 PLCE1

Molecular functions related to Gastric Cardia Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.8 PLCE1 WWOX XRCC1

Sources for Gastric Cardia Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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