MCID: GST042
MIFTS: 33

Gastric Diffuse Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Diffuse Adenocarcinoma

MalaCards integrated aliases for Gastric Diffuse Adenocarcinoma:

Name: Gastric Diffuse Adenocarcinoma 12 15
Carcinoma, Diffuse Type 12 74
Adenocarcinoma of Linitis Plastica Type 12
Diffuse Gastric Adenocarcinoma 17
Diffuse Type Adenocarcinoma 12
Diffuse Type Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6217
NCIt 51 C4127 C9159
SNOMED-CT 69 24505004

Summaries for Gastric Diffuse Adenocarcinoma

MalaCards based summary : Gastric Diffuse Adenocarcinoma, also known as carcinoma, diffuse type, is related to gastric adenocarcinoma and gastric cancer, hereditary diffuse. An important gene associated with Gastric Diffuse Adenocarcinoma is CDH1 (Cadherin 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Arf6 trafficking events. The drugs acetic acid and Retinol acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, appendix and lung.

Related Diseases for Gastric Diffuse Adenocarcinoma

Diseases related to Gastric Diffuse Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 gastric adenocarcinoma 29.8 CDH1 CDX2 KRT20 KRT7
2 gastric cancer, hereditary diffuse 11.6
3 goblet cell carcinoid 10.3 CDH1 KRT20
4 morpheaform basal cell carcinoma 10.3 CDH1 KRT20
5 vaginal benign neoplasm 10.3 CDX2 KRT20
6 vaginal adenoma 10.3 CDX2 KRT20
7 vaginal tubulovillous adenoma 10.3 CDX2 KRT20
8 villous adenoma 10.3 CDX2 KRT20
9 microinvasive gastric cancer 10.3 CDH1 CDX2
10 lobular neoplasia 10.3 CDH1 CTNNA1
11 sarcomatoid renal cell carcinoma 10.2 CDH1 GATA3
12 chronic cholangitis 10.2 CDX2 MMP15
13 renal pelvis adenocarcinoma 10.2 CDH1 KRT7
14 diffuse gastric cancer 10.2 CDH1 CTNNA1
15 embryoma 10.2 CDX2 GATA3
16 cystic basal cell carcinoma 10.2 KRT20 KRT7
17 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
18 transverse colon cancer 10.2 KRT20 KRT7
19 malignant syringoma 10.2 KRT20 KRT7
20 papillary transitional carcinoma 10.2 KRT20 KRT7
21 eyelid carcinoma 10.2 KRT20 KRT7
22 krukenberg carcinoma 10.2 KRT20 KRT7
23 lung acinar adenocarcinoma 10.2 KRT20 KRT7
24 small cell carcinoma of the bladder 10.2 KRT20 KRT7
25 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
26 small cell carcinoma 10.2 KRT20 KRT7
27 intratubular embryonal carcinoma 10.2 KRT20 KRT7
28 vulval paget's disease 10.2 KRT20 KRT7
29 bile duct cystadenocarcinoma 10.2 KRT20 KRT7
30 mucinous adenofibroma 10.2 CDX2 KRT7
31 anus adenocarcinoma 10.2 CDX2 KRT7
32 bile duct adenoma 10.2 KRT20 KRT7
33 meibomian cyst 10.2 KRT20 KRT7
34 bladder lymphoma 10.2 KRT20 KRT7
35 papillary serous adenocarcinoma 10.1 KRT20 KRT7
36 tubular adenocarcinoma 10.1 CDH1 CDX2 KRT20
37 duodenum adenocarcinoma 10.1 CDX2 KRT7
38 epithelial predominant wilms' tumor 10.1 CDX2 KRT7
39 breast adenomyoepithelioma 10.1 CDH1 KRT7
40 medulloepithelioma 10.1 KRT20 KRT7
41 breast myoepithelial neoplasm 10.1 CDH1 KRT7
42 glycogen-rich clear cell breast carcinoma 10.1 KRT20 KRT7
43 nasal cavity cancer 10.1 CDX2 KRT7
44 cystadenoma 10.1 KRT20 KRT7
45 renal pelvis carcinoma 10.1 KRT20 KRT7
46 paget disease, extramammary 10.1 KRT20 KRT7
47 nasal cavity adenocarcinoma 10.1 CDX2 KRT7
48 anal canal adenocarcinoma 10.1 CDX2 KRT7
49 eccrine sweat gland neoplasm 10.1 KRT20 KRT7
50 mucinous ovarian cystadenoma 10.1 CDX2 KRT7

Graphical network of the top 20 diseases related to Gastric Diffuse Adenocarcinoma:



Diseases related to Gastric Diffuse Adenocarcinoma

Symptoms & Phenotypes for Gastric Diffuse Adenocarcinoma

Drugs & Therapeutics for Gastric Diffuse Adenocarcinoma

Drugs for Gastric Diffuse Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
acetic acid Approved Not Applicable 64-19-7 176
2
Retinol acetate Not Applicable 127-47-9 10245972

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Screening for Familial Gastric Cancer in First Degree Relatives Unknown status NCT01727908 Not Applicable

Search NIH Clinical Center for Gastric Diffuse Adenocarcinoma

Genetic Tests for Gastric Diffuse Adenocarcinoma

Anatomical Context for Gastric Diffuse Adenocarcinoma

MalaCards organs/tissues related to Gastric Diffuse Adenocarcinoma:

42
Breast, Appendix, Lung, Kidney, Ovary, Thymus, Small Intestine

Publications for Gastric Diffuse Adenocarcinoma

Articles related to Gastric Diffuse Adenocarcinoma:

# Title Authors Year
1
Concurrence of duodenal carcinoid and diffuse gastric adenocarcinoma: a rare phenomenon. ( 19858647 )
2007
2
E-cadherin mutation-associated diffuse gastric adenocarcinoma: penetrance and non-penetrance. ( 16292101 )
2005
3
[Microangiopathic hemolytic anemia and thrombocytopenia (cancer-related thrombotic thrombocytopenic purpura) in a patient with diffuse gastric adenocarcinoma]. ( 12673940 )
2003

Variations for Gastric Diffuse Adenocarcinoma

Expression for Gastric Diffuse Adenocarcinoma

Search GEO for disease gene expression data for Gastric Diffuse Adenocarcinoma.

Pathways for Gastric Diffuse Adenocarcinoma

GO Terms for Gastric Diffuse Adenocarcinoma

Cellular components related to Gastric Diffuse Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 8.96 CDH1 CTNNA1
2 flotillin complex GO:0016600 8.62 CDH1 CTNNA1

Biological processes related to Gastric Diffuse Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell differentiation GO:0045597 9.32 CDX2 GATA3
2 adherens junction organization GO:0034332 9.26 CDH1 CTNNA1
3 negative regulation of cell motility GO:2000146 9.16 CTNNA1 GATA3
4 male gonad development GO:0008584 9.13 CTNNA1 GATA3 NUDT1
5 cellular response to indole-3-methanol GO:0071681 8.62 CDH1 CTNNA1

Molecular functions related to Gastric Diffuse Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gamma-catenin binding GO:0045295 8.62 CDH1 CTNNA1

Sources for Gastric Diffuse Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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