MCID: GST042
MIFTS: 29

Gastric Diffuse Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Diffuse Adenocarcinoma

MalaCards integrated aliases for Gastric Diffuse Adenocarcinoma:

Name: Gastric Diffuse Adenocarcinoma 12 15
Diffuse Gastric Adenocarcinoma 17
Carcinoma, Diffuse Type 70

Classifications:



External Ids:

Disease Ontology 12 DOID:6217
NCIt 50 C4127 C9159
SNOMED-CT 67 24505004
UMLS 70 C0279635 C0334280

Summaries for Gastric Diffuse Adenocarcinoma

Disease Ontology : 12 A gastric adenocarcinoma that is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma.

MalaCards based summary : Gastric Diffuse Adenocarcinoma, also known as diffuse gastric adenocarcinoma, is related to gastric adenocarcinoma and adenocarcinoma. An important gene associated with Gastric Diffuse Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Gastric cancer and Preimplantation Embryo. Affiliated tissues include breast, colon and liver, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Gastric Diffuse Adenocarcinoma

Diseases related to Gastric Diffuse Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 gastric adenocarcinoma 30.0 KRT20 ERBB2 CEACAM5 CDX2 CDH1
2 adenocarcinoma 29.3 KRT7 KRT20 ERBB2 CEACAM5 CDX2 CDH1
3 gastric cancer, hereditary diffuse 11.5
4 ceruminoma 10.4 PIP KRT7
5 bile duct adenoma 10.4 KRT7 KRT20
6 gallbladder signet ring cell adenocarcinoma 10.4 KRT7 CDH1
7 ceruminous adenocarcinoma 10.4 PIP KRT7
8 ovarian cystadenoma 10.3 KRT7 CEACAM5
9 syringoma 10.3 KRT7 CEACAM5
10 bladder benign neoplasm 10.3 KRT7 KRT20
11 nephrogenic adenoma of urinary bladder 10.3 KRT7 KRT20
12 nipples, supernumerary 10.3 PIP KRT20
13 atrophic vulva 10.3 KRT7 KRT20
14 ovary neuroendocrine neoplasm 10.3 KRT7 CDX2
15 erysipeloid 10.3 PIP KRT7
16 papillary adenoma 10.3 KRT7 CEACAM5
17 lung acinar adenocarcinoma 10.3 PIP KRT20
18 anal gland adenocarcinoma 10.3 KRT7 CDX2
19 anus adenocarcinoma 10.3 KRT7 CDX2
20 dacryocystocele 10.3 PIP KRT7
21 chronic inflammation of lacrimal passage 10.3 PIP KRT7
22 adenosquamous colon carcinoma 10.3 KRT7 CDX2
23 leukoplakia of penis 10.3 KRT7 CEACAM5
24 jejunal neoplasm 10.3 KRT7 KRT20
25 tinea cruris 10.3 PIP KRT7
26 intratubular embryonal carcinoma 10.3 KRT7 KRT20
27 ovarian large-cell neuroendocrine carcinoma 10.3 KRT7 KRT20
28 papillary transitional carcinoma 10.3 KRT7 KRT20
29 supine hypotensive syndrome 10.3 KRT7 KRT20
30 meibomian cyst 10.3 KRT7 KRT20
31 mucinous intrahepatic cholangiocarcinoma 10.3 KRT7 CDX2
32 rectum neuroendocrine neoplasm 10.3 KRT7 CDX2
33 acute orbital inflammation 10.3 KRT7 KRT20
34 nephrogenic adenoma of the urethra 10.3 KRT7 KRT20
35 goblet cell carcinoid 10.3 KRT20 CDH1
36 eccrine porocarcinoma 10.3 KRT7 CEACAM5
37 ovarian brenner tumor 10.3 KRT7 KRT20
38 fox-fordyce disease 10.3 PIP CEACAM5
39 bile duct cystadenocarcinoma 10.3 KRT7 CEACAM5
40 prostate neuroendocrine neoplasm 10.3 KRT7 KRT20
41 mucinous stomach adenocarcinoma 10.3 KRT7 CDX2
42 vulvar eccrine porocarcinoma 10.3 PIP CEACAM5
43 papillary squamous carcinoma 10.3 KRT7 CEACAM5
44 nodular hidradenoma 10.3 PIP CEACAM5
45 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
46 biliary papillomatosis 10.3 KRT7 CEACAM5
47 bile duct mucoepidermoid carcinoma 10.3 KRT7 CEACAM5
48 pericardium cancer 10.3 KRT7 CEACAM5
49 liver sarcoma 10.3 KRT7 CEACAM5
50 maxillary sinus benign neoplasm 10.3 CEACAM5 CDH1

Graphical network of the top 20 diseases related to Gastric Diffuse Adenocarcinoma:



Diseases related to Gastric Diffuse Adenocarcinoma

Symptoms & Phenotypes for Gastric Diffuse Adenocarcinoma

MGI Mouse Phenotypes related to Gastric Diffuse Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CDH1 CDX2 ERBB2 GATA3 HSF4 PGR
2 digestive/alimentary MP:0005381 9.43 ATP4B CDH1 CDX2 ERBB2 GATA3 PIP
3 endocrine/exocrine gland MP:0005379 9.17 ATP4B CDH1 CDX2 ERBB2 GATA3 PGR

Drugs & Therapeutics for Gastric Diffuse Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Gastric Diffuse Adenocarcinoma

Genetic Tests for Gastric Diffuse Adenocarcinoma

Anatomical Context for Gastric Diffuse Adenocarcinoma

MalaCards organs/tissues related to Gastric Diffuse Adenocarcinoma:

40
Breast, Colon, Liver, Lung, Ovary, Appendix, Kidney

Publications for Gastric Diffuse Adenocarcinoma

Articles related to Gastric Diffuse Adenocarcinoma:

(show all 20)
# Title Authors PMID Year
1
Anti-fibrotic properties of an adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma. 61
33442414 2021
2
Mining topoisomerase isoforms in gastric cancer. 61
32535049 2020
3
Predictors of self-expanding metallic stent dysfunction in malignant gastric outlet obstruction. 61
32229056 2020
4
Biflorin inhibits the proliferation of gastric cancer cells by decreasing MYC expression. 61
31751609 2020
5
Tailoring subtractive cell biopanning to identify diffuse gastric adenocarcinoma-associated antigens via human scFv antibodies. 61
31596953 2020
6
Specific Histopathologic Features Aid in Distinguishing Diffuse-type Gastric Adenocarcinoma From Metastatic Lobular Breast Carcinoma. 61
31403964 2020
7
Is prophylactic gastrectomy indicated for healthy carriers of CDH1 gene mutations associated with hereditary diffuse gastric cancer? 61
30466290 2019
8
Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer. 61
28943959 2017
9
A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer. 61
28911091 2017
10
Survival following operative management of gastric linitis plastica compared with non-operative management. 61
27809576 2017
11
Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer. 61
27015121 2016
12
Synchronous gastric and colonic cancer--A case report. 61
26364460 2015
13
[Diffuse gastric cancer associated with Ménétrier's disease]. 61
21894728 2011
14
Concurrence of duodenal carcinoid and diffuse gastric adenocarcinoma: a rare phenomenon. 61
19858647 2007
15
Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer. 61
17659675 2007
16
CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. 61
17522512 2007
17
E-cadherin mutation-associated diffuse gastric adenocarcinoma: penetrance and non-penetrance. 61
16292101 2005
18
[Microangiopathic hemolytic anemia and thrombocytopenia (cancer-related thrombotic thrombocytopenic purpura) in a patient with diffuse gastric adenocarcinoma]. 61
12673940 2003
19
'Mucin-positive' epithelial mesothelioma of the peritoneum: an unusual diagnostic pitfall. 61
10931216 2000
20
[Gastric carcinoma in patients younger than 30 years of age. Report of 11 cases]. 61
9453753 1997

Variations for Gastric Diffuse Adenocarcinoma

Expression for Gastric Diffuse Adenocarcinoma

Search GEO for disease gene expression data for Gastric Diffuse Adenocarcinoma.

Pathways for Gastric Diffuse Adenocarcinoma

Pathways related to Gastric Diffuse Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 PGR ERBB2 CDX2 CDH1
2 10.58 GATA3 CDX2 CDH1

GO Terms for Gastric Diffuse Adenocarcinoma

Biological processes related to Gastric Diffuse Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell differentiation GO:0045597 8.8 HSF4 GATA3 CDX2

Molecular functions related to Gastric Diffuse Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.26 PGR HSF4 GATA3 CDX2
2 identical protein binding GO:0042802 9.17 PIP PGR HSF4 GATA3 ERBB2 CEACAM5

Sources for Gastric Diffuse Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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