MCID: GST007
MIFTS: 32

Gastric Dilatation

Categories: Gastrointestinal diseases
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Aliases & Classifications for Gastric Dilatation

MalaCards integrated aliases for Gastric Dilatation:

Name: Gastric Dilatation 11 43 14 71
Stomach Dilatation 11

Classifications:



External Ids:

Disease Ontology 11 DOID:3229
MeSH 43 D013271
UMLS 71 C0038353

Summaries for Gastric Dilatation

MalaCards based summary: Gastric Dilatation, also known as stomach dilatation, is related to volvulus of midgut and diaphragmatic hernia, congenital. An important gene associated with Gastric Dilatation is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Sphingolipid metabolism and "Gamma carboxylation, hypusine formation and arylsulfatase activation". The drugs Peppermint and Papain have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, adrenal cortex and lung.

Related Diseases for Gastric Dilatation

Diseases related to Gastric Dilatation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 431)
# Related Disease Score Top Affiliating Genes
1 volvulus of midgut 30.7 TNNI3 CRP ATP4A ATP12A ALB
2 diaphragmatic hernia, congenital 30.7 CRP ATP4A ATP12A
3 megaesophagus 30.4 ATP4A ATP12A
4 compartment syndrome 30.2 CRP ALB
5 superior mesenteric artery syndrome 30.2 CRP ATP4A ATP12A ALB
6 third-degree atrioventricular block 30.0 TNNI3 CRP
7 aspiration pneumonia 29.9 CRP ATP4A ATP12A ALB
8 intestinal obstruction 29.8 CRP ATP4A ATP12A ALB
9 gastroesophageal reflux 29.7 GHRL ATP4A ATP12A
10 splenic infarction 29.6 CRP ALB
11 graves disease 1 29.6 CRP ALB
12 hernia, hiatus 29.5 GHRL CRP ATP4A ATP12A ALB
13 anuria 29.5 CRP ALB
14 aortic dissection 29.4 TNNI3 CRP ALB
15 pulmonary embolism 29.4 TNNI3 CRP ALB
16 duodenal obstruction 29.3 ST7 CRP ATP4A ATP12A ALB
17 chronic intestinal vascular insufficiency 29.3 CRP ATP4A ATP12A ALB
18 paralytic ileus 29.3 CRP ATP4A ATP12A ALB
19 bronchopneumonia 29.2 CRP ALB
20 nutritional deficiency disease 28.9 GHRL CRP ATP4A ATP12A ALB
21 anorexia nervosa 10.5
22 bulimia nervosa 10.5
23 eating disorder 10.4
24 pancreatic vasoactive intestinal peptide producing tumor 10.3 ATP4A ATP12A
25 acquired laryngomalacia 10.3 ATP4A ATP12A
26 laryngomalacia 10.3 ATP4A ATP12A
27 scalp dermatosis 10.3 ATP4A ATP12A
28 acquired gastric outlet stenosis 10.3 ATP4A ATP12A
29 lingual goiter 10.3 ATP4A ATP12A
30 esophageal diverticulosis 10.3 ATP4A ATP12A
31 displacement of cardia through esophageal hiatus 10.3 ATP4A ATP12A
32 benign shuddering attacks 10.3 ATP4A ATP12A
33 persistent moderate asthma 10.3 ATP4A ATP12A
34 viral esophagitis 10.3 ATP4A ATP12A
35 cervix erosion 10.3 ATP4A ATP12A
36 bacterial esophagitis 10.3 ATP4A ATP12A
37 angiodysplasia of intestine 10.3 ATP4A ATP12A
38 angiodysplasia 10.3 ATP4A ATP12A
39 benzylpenicillin allergy 10.3 ATP4A ATP12A
40 granulomatous gastritis 10.3 ATP4A ATP12A
41 fungal gastritis 10.3 ATP4A ATP12A
42 fungal esophagitis 10.3 ATP4A ATP12A
43 esophagus melanoma 10.3 ATP4A ATP12A
44 afferent loop syndrome 10.3 ATP4A ATP12A
45 laryngeal tuberculosis 10.3 ATP4A ATP12A
46 gastrojejunal ulcer 10.3 ATP4A ATP12A
47 cefuroxime allergy 10.3 ATP4A ATP12A
48 bacterial gastritis 10.3 ATP4A ATP12A
49 dieulafoy lesion 10.3 ATP4A ATP12A
50 hypopigmentation of eyelid 10.3 ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastric Dilatation:



Diseases related to Gastric Dilatation

Symptoms & Phenotypes for Gastric Dilatation

Drugs & Therapeutics for Gastric Dilatation

Drugs for Gastric Dilatation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Peppermint Approved
2
Papain Approved 9001-73-4
3
Ginger Approved
4
Fennel Approved, Experimental

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Examining the Effectiveness of Digestive Enzymes at Reducing Bloating and Stomach Distension Active, not recruiting NCT05520411

Search NIH Clinical Center for Gastric Dilatation

Cochrane evidence based reviews: gastric dilatation

Genetic Tests for Gastric Dilatation

Anatomical Context for Gastric Dilatation

Organs/tissues related to Gastric Dilatation:

MalaCards : Spinal Cord, Adrenal Cortex, Lung, Ovary, Liver, Cortex, Colon

Publications for Gastric Dilatation

Articles related to Gastric Dilatation:

(show top 50) (show all 733)
# Title Authors PMID Year
1
Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide. 62
35983392 2022
2
An atypical gastric duplication cyst as a rare cause of gastric dilatation: the key role of the endoscopy ultrasound. 62
35899693 2022
3
Early career clinicians euthanize more dogs with nontraumatic hemoabdomen but not gastric dilatation and volvulus than more experienced clinicians. 62
35905147 2022
4
Outcomes of dogs undergoing surgery for gastric dilatation volvulus after rapid versus prolonged medical stabilization. 62
34989433 2022
5
Counterclockwise gastric dilatation and volvulus in a dog. 62
35784770 2022
6
Allogeneic peripheral blood haematopoietic stem cell transplantation for the treatment of dogs with high-grade B-cell lymphoma. 62
35789057 2022
7
Endoscopic management of giant gastric dilatation in an anorexia nervosa patient after binge eating. 62
34820803 2022
8
[Studies on the use of iodine-containing contrast agent diatrizoate in rabbits (Oryctolagus cuniculus)]. 62
35523165 2022
9
Gastric Pneumatosis with Portal Venous Gas can be Treated Non-operatively: A Retrospective Multi-institutional Study. 62
35128570 2022
10
Military Working Dogs Operating in Afghanistan Theater: Comparison between Pre- and Post-Mission Blood Analyses to Monitor Physical Fitness and Training. 62
35268187 2022
11
Updated Information on Gastric Dilatation and Volvulus and Gastropexy in Dogs. 62
35082096 2022
12
Prenatal imaging features and perinatal outcomes of foetal volvulus-A literature review. 62
34981841 2022
13
Pathophysiology of intraabdominal hypertension and abdominal compartment syndrome and relevance to veterinary critical care. 62
35044059 2022
14
Acupuncture Enhances Gastrointestinal Motility and Improves Autonomic Nervous Function in Patients with Septic Gastrointestinal Dysfunction. 62
36188104 2022
15
Mortality trends for five species of macropods from a single institution from 1995 to 2016. 62
34455635 2022
16
Chronic gastric dilatation with gastric fundus perforation in anorexia nervosa patient. 62
34991050 2022
17
Anorexia nervosa and pancreatitis. 62
34983221 2021
18
Medical conditions associated with gastroduodenal ulceration or erosion in 168 dogs: 2008-2018. 62
34596276 2021
19
Comparison of Perinatal Outcomes between Patients with Suspected Complex and Simple Gastroschisis. 62
34666388 2021
20
Sleeve gastrectomy for idiopathic acute gastric dilatation with transmural necrosis. 62
34431688 2021
21
Pet health insurance reduces the likelihood of pre-surgical euthanasia of dogs with gastric dilatation-volvulus in the emergency room of an Australian referral hospital. 62
33896404 2021
22
Acute Gastric Dilatation Leading to Ischemic Necrosis: A rare complication following sigmoid volvulus. 62
34522424 2021
23
Liver Lobe Torsion in a Guinea Pig (Cavia porcellus). 62
33548548 2021
24
Hepatic portal vein gas associated with intestinal ischemia and acute gastric dilatation: a case report. 62
33691431 2021
25
Acute gastric dilatation in a patient with anorexia nervosa. 62
33207908 2021
26
Acute gastric dilatation is a potentially fatal complication in Parkinson's disease. 62
33744692 2021
27
Comparison of total laparoscopic gastropexy with the Ethicon Securestrap fixation device versus knotless barbed suture in dogs. 62
33835588 2021
28
Acute gastric dilatation: a life-threatening early complication following laparoscopic hiatus hernia repair. 62
32820843 2021
29
Massive Acute Gastric Dilatation in a Patient with Anorexia Nervosa. 62
32632731 2021
30
Adult hypertrophic pyloric stenosis that improved by spontaneous double channel pylorus formation. 62
33553675 2021
31
Acute Massive Gastric Dilatation and Gastric Perforation as a Result of Closed-Loop Obstruction of the Stomach. 62
33747660 2021
32
Acute gastric dilatation in a patient with severe anorexia nervosa: a case report. 62
33557865 2021
33
Unusual complication after laparoscopic Nissen fundoplication. 62
33613966 2021
34
Development of Sciatic Neuropraxia following Abdominal Surgery in 3 Giant Breed Dogs. 62
34616581 2021
35
Longitudinal Gastrectomy for Nonbariatric Indications. 62
34035960 2021
36
Development of a prenatal clinical care pathway for uncomplicated gastroschisis and literature review. 62
32145003 2021
37
Kinetics of Plasma Cytokines, Angiopoietin-2, and C-Reactive Protein in Dogs With Gastric Dilatation Volvulus. 62
34222394 2021
38
Evaluation of a staged technique of immediate decompressive and delayed surgical treatment for gastric dilatation-volvulus in dogs. 62
33314975 2021
39
Acute Gastric Dilatation: A Cause for Concern. 62
33708066 2021
40
A case of gastric ischemia caused by massive gastric dilatation due to superior mesenteric artery syndrome. 62
32720221 2020
41
CT findings in dogs with gastric malposition: 6 cases (2016-2019). 62
32974915 2020
42
Identification of Genetic Susceptibility Factors Associated with Canine Gastric Dilatation-Volvulus. 62
33167491 2020
43
Groove pancreatitis: a rare cause of severe gastric dilation. 62
33054295 2020
44
Sounds unrealistic: an adolescent girl with anorexia nervosa consumes 19 L of fluid in a few hours: what happens to the physiology? 62
31522380 2020
45
Acupuncture Combined with Early Enteral Nutrition on Patients with Postoperative Laparoscopic Common Bile Duct Exploration: A Prospective Randomized Trial. 62
31848889 2020
46
Acute massive gastric dilatation as a result of closed-loop obstruction of stomach: an unusual and rare phenomenon. 62
32878832 2020
47
Colonic torsion in 4 Great Danes. 62
32710595 2020
48
[Wilkie's syndrome caused by exogenous hyperthyroidism in a patient with primary autoimmune hypothyroidism: a case report and literature review]. 62
33181816 2020
49
Retrospective analysis of 736 cases of canine gastric dilatation volvulus. 62
32253749 2020
50
Acute massive gastric dilatation: a rare, forgotten complication of fundoplication. 62
32467115 2020

Variations for Gastric Dilatation

Expression for Gastric Dilatation

Search GEO for disease gene expression data for Gastric Dilatation.

Pathways for Gastric Dilatation

GO Terms for Gastric Dilatation

Cellular components related to Gastric Dilatation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.47 GHRL ARSK ARSI ARSH ARSF ARSD

Biological processes related to Gastric Dilatation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion export across plasma membrane GO:0036376 9.46 ATP4A ATP12A
2 cellular potassium ion homeostasis GO:0030007 9.26 ATP4A ATP12A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.92 ATP4A ATP12A

Molecular functions related to Gastric Dilatation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.22 TNNI3 CRP ATP4A ATP12A ARSK ARSI
2 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.67 ATP4A ATP12A
3 arylsulfatase activity GO:0004065 9.65 ARSK ARSI ARSH ARSF ARSD
4 P-type potassium:proton transporter activity GO:0008900 9.46 ATP4A ATP12A
5 P-type potassium transmembrane transporter activity GO:0008556 9.26 ATP12A ATP4A
6 sulfuric ester hydrolase activity GO:0008484 9.02 ARSK ARSI ARSH ARSF ARSD

Sources for Gastric Dilatation

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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