MCID: GST026
MIFTS: 32

Gastric Fundus Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Fundus Cancer

MalaCards integrated aliases for Gastric Fundus Cancer:

Name: Gastric Fundus Cancer 12 15
Gastric Fundus Carcinoma 12 15 71
Malignant Neoplasm of Fundus of Stomach 12
Malignant Tumor of Fundus of Stomach 12
Malignant Neoplasm of Gastric Fundus 71
Carcinoma of Fundus of Stomach 12
Cancer of Fundus of Stomach 12
Ca Fundus - Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10538 DOID:6700
ICD9CM 34 151.3
NCIt 50 C8398
SNOMED-CT 67 254555008 93809003
ICD10 32 C16.1
UMLS 71 C0153420 C0345799

Summaries for Gastric Fundus Cancer

MalaCards based summary : Gastric Fundus Cancer, also known as gastric fundus carcinoma, is related to tuberculous peritonitis and duodenal obstruction, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Fundus Cancer is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are ERK Signaling and Developmental Biology. Related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Gastric Fundus Cancer

Diseases related to Gastric Fundus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 10.3 CEACAM5 ALB
2 duodenal obstruction 10.2 CEACAM5 ALB
3 gastrointestinal tuberculosis 10.2 CEACAM5 ALB
4 mucinous ovarian cystadenoma 10.2 GAST CEACAM5
5 cerebral hypoxia 10.2 ITGB1 ITGAV
6 acute cholangitis 10.2 CEACAM5 ALB
7 common bile duct disease 10.2 CEACAM5 ALB
8 abdominal tuberculosis 10.2 CEACAM5 ALB
9 renal pelvis adenocarcinoma 10.2 KRT19 CEACAM5
10 vulvar apocrine adenocarcinoma 10.2 KRT19 CEACAM5
11 paratesticular lipoma 10.1 KRT19 CEACAM5
12 lipoma of spermatic cord 10.1 KRT19 CEACAM5
13 anal canal adenocarcinoma 10.1 KRT19 CEACAM5
14 pericardium cancer 10.1 KRT19 CEACAM5
15 eccrine sweat gland cancer 10.1 KRT19 CEACAM5
16 hidrocystoma 10.1 KRT19 CEACAM5
17 eccrine papillary adenocarcinoma 10.1 KRT19 CEACAM5
18 biliary tract benign neoplasm 10.1 KRT19 CEACAM5
19 sarcomatous intrahepatic cholangiocarcinoma 10.1 KRT19 CEACAM5
20 cutaneous adenocystic carcinoma 10.1 KRT19 CEACAM5
21 ostertagiasis 10.1 GAST ALB
22 clear cell basal cell carcinoma 10.1 KRT19 CEACAM5
23 nasal cavity olfactory neuroblastoma 10.1 KRT19 CEACAM5
24 sveinsson chorioretinal atrophy 10.1 YAP1 TEAD1 ALB
25 vaginal discharge 10.1 CEACAM5 ALB
26 tropical sprue 10.1 GAST ALB
27 eccrine porocarcinoma 10.1 KRT19 CEACAM5
28 ovarian germ cell cancer 10.0 KRT19 CEACAM5
29 melon allergy 10.0 GAST ALB
30 intrahepatic gall duct cancer 10.0 KRT19 ALB
31 gastritis, familial giant hypertrophic 10.0 GAST ALB
32 intrahepatic bile duct adenoma 10.0 KRT19 ITGAV CEACAM5
33 mandibular cancer 10.0 KRT19 CEACAM5
34 spinocerebellar ataxia 45 10.0 YAP1 FAT1 CDH17
35 benign peritoneal mesothelioma 10.0 KRT19 CEACAM5
36 peptic esophagitis 10.0 GAST ALB
37 eccrine acrospiroma 10.0 YAP1 KRT19 CEACAM5
38 eccrine sweat gland neoplasm 10.0 YAP1 KRT19 CEACAM5
39 duodenitis 10.0 GAST ALB
40 eccrine papillary adenoma 10.0 KRT19 CEACAM5
41 hemorrhoid 10.0 CEACAM5 ALB
42 splenic tuberculosis 9.9 KRT19 CEACAM5 ALB
43 bile duct cysts 9.9 KRT19 CEACAM5 ALB
44 klatskin's tumor 9.9 KRT19 CEACAM5 ALB
45 bile reflux 9.9 GAST ALB
46 bile duct adenocarcinoma 9.9 KRT19 CEACAM5 ALB
47 cholangitis, primary sclerosing 9.9 KRT19 CEACAM5 ALB
48 bile duct disease 9.9 KRT19 CEACAM5 ALB
49 colon neuroendocrine neoplasm 9.9 KRT19 GAST CEACAM5
50 gastrointestinal carcinoma 9.9 KRT19 GAST CEACAM5

Comorbidity relations with Gastric Fundus Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Deficiency Anemia
Gastric Cancer

Graphical network of the top 20 diseases related to Gastric Fundus Cancer:



Diseases related to Gastric Fundus Cancer

Symptoms & Phenotypes for Gastric Fundus Cancer

UMLS symptoms related to Gastric Fundus Cancer:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Fundus Cancer:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.35 ALB ERBB3 FAT1 FGF10 IGF2R ITGAV
2 endocrine/exocrine gland MP:0005379 10.34 ALB ERBB3 FGF10 GAST IGF2R ITGAV
3 cellular MP:0005384 10.31 ALB ERBB3 FGF10 IGF2R ITGAV ITGB1
4 homeostasis/metabolism MP:0005376 10.31 ALB ERBB3 FAT1 FGF10 GAST IGF2R
5 mortality/aging MP:0010768 10.31 ALB ERBB3 FAT1 FGF10 GAST IGF2R
6 immune system MP:0005387 10.29 ALB CDH17 ERBB3 FAT1 FGF10 GAST
7 digestive/alimentary MP:0005381 10.25 ALB CDH17 ERBB3 FGF10 GAST ITGAV
8 embryo MP:0005380 10.24 ERBB3 FGF10 IGF2R ITGAV ITGB1 KRT19
9 craniofacial MP:0005382 10.21 FAT1 FGF10 IGF2R ITGAV ITGB1 KRT19
10 muscle MP:0005369 10.1 ALB ERBB3 FAT1 FGF10 ITGAV ITGB1
11 nervous system MP:0003631 10.1 ALCAM ERBB3 FAT1 FGF10 IGF2R ITGAV
12 integument MP:0010771 10.06 ERBB3 FAT1 FGF10 ITGB1 KRT19 NOG
13 hearing/vestibular/ear MP:0005377 9.99 FAT1 FGF10 ITGB1 NOG TEAD1 WNT1
14 neoplasm MP:0002006 9.91 ALB ERBB3 GAST ITGAV ITGB1 KRT19
15 normal MP:0002873 9.86 ALB ERBB3 FGF10 IGF2R ITGB1 KRT19
16 renal/urinary system MP:0005367 9.81 ALB FAT1 FGF10 IGF2R ITGAV ITGB1
17 respiratory system MP:0005388 9.56 ERBB3 FGF10 IGF2R ITGB1 KRT19 NOG
18 skeleton MP:0005390 9.28 FAT1 FGF10 IGF2R ITGB1 KRT19 NOG

Drugs & Therapeutics for Gastric Fundus Cancer

Search Clinical Trials , NIH Clinical Center for Gastric Fundus Cancer

Genetic Tests for Gastric Fundus Cancer

Anatomical Context for Gastric Fundus Cancer

Publications for Gastric Fundus Cancer

Variations for Gastric Fundus Cancer

Expression for Gastric Fundus Cancer

Search GEO for disease gene expression data for Gastric Fundus Cancer.

Pathways for Gastric Fundus Cancer

Pathways related to Gastric Fundus Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 WNT1 TEAD1 ITGB1 ITGAV IGF2R FGF10
2
Show member pathways
13.3 WNT1 KRT19 ITGB1 ITGAV FGF10 ERBB3
3
Show member pathways
12.79 WNT1 ITGB1 ITGAV FGF10 ERBB3
4
Show member pathways
12.29 WNT1 RSPO1 IGF2R ERBB3
5 12.21 WNT1 TEAD1 GAST CDH17
6
Show member pathways
12.2 ITGB1 ITGAV IGF2R ERBB3
7 12.07 WNT1 ITGB1 ITGAV ERBB3
8
Show member pathways
11.96 PPIA ITGB1 ITGAV CEACAM5
9
Show member pathways
11.9 YAP1 ITGB1 ITGAV IGF2R ERBB3
10
Show member pathways
11.85 ITGB1 ITGAV ALCAM
11
Show member pathways
11.84 ITGB1 ITGAV ERBB3
12 11.65 ITGB1 ITGAV CEACAM5 CDH17
13 11.53 ITGB1 ITGAV FGF10 ERBB3
14 11.43 NOG ITGB1 FGF10 ALCAM
15 11.36 ITGB1 ITGAV ERBB3
16 11.23 WNT1 NOG FGF10
17 11.22 NOG KRT19 ITGB1 FGF10 ALCAM ALB
18 11.13 WNT1 ITGB1 ITGAV FAT1
19 10.91 ITGB1 ITGAV
20 10.8 ITGB1 ITGAV FGF10 ERBB3 CDH17

GO Terms for Gastric Fundus Cancer

Cellular components related to Gastric Fundus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 WNT1 RSPO1 PPIA NOG GAST FGF10
2 extracellular space GO:0005615 9.92 WNT1 PPIA NOG IGF2R GAST FGF10
3 extracellular exosome GO:0070062 9.85 WNT1 PPIA KRT19 ITGB1 ITGAV IGF2R
4 focal adhesion GO:0005925 9.43 PPIA ITGB1 ITGAV IGF2R FAT1 ALCAM
5 cell surface GO:0009986 9.17 WNT1 ITGB1 ITGAV IGF2R FGF10 CEACAM5

Biological processes related to Gastric Fundus Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 YAP1 WNT1 ITGAV FGF10 ERBB3
2 positive regulation of protein phosphorylation GO:0001934 9.76 WNT1 RSPO1 PPIA FGF10
3 integrin-mediated signaling pathway GO:0007229 9.7 ITGB1 ITGAV CDH17
4 positive regulation of epithelial cell proliferation GO:0050679 9.67 YAP1 NOG FGF10
5 leukocyte migration GO:0050900 9.67 PPIA ITGB1 ITGAV CEACAM5
6 cell adhesion GO:0007155 9.63 ITGB1 ITGAV FAT1 CEACAM5 CDH17 ALCAM
7 somatic stem cell population maintenance GO:0035019 9.61 YAP1 NOG FGF10
8 negative regulation of cell differentiation GO:0045596 9.58 WNT1 NOG FGF10
9 lung morphogenesis GO:0060425 9.56 NOG FGF10
10 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.56 ITGB1 FAT1 CEACAM5 CDH17
11 cell-substrate adhesion GO:0031589 9.55 ITGB1 ITGAV
12 negative regulation of anoikis GO:2000811 9.54 ITGB1 CEACAM5
13 positive regulation of Notch signaling pathway GO:0045747 9.5 YAP1 WNT1 FGF10
14 bud elongation involved in lung branching GO:0060449 9.48 YAP1 FGF10
15 prostatic bud formation GO:0060513 8.96 NOG FGF10
16 wound healing GO:0042060 8.92 YAP1 NOG FGF10 ERBB3

Molecular functions related to Gastric Fundus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuregulin binding GO:0038132 9.16 ITGAV ERBB3
2 C-X3-C chemokine binding GO:0019960 8.96 ITGB1 ITGAV
3 integrin binding GO:0005178 8.92 PPIA ITGB1 ITGAV CDH17

Sources for Gastric Fundus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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