Gastric Gastrinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Gastric Gastrinoma

MalaCards integrated aliases for Gastric Gastrinoma:

Name: Gastric Gastrinoma ¹² ¹⁵

Gastric Gastrin-Producing Neuroendocrine Tumor ⁷¹

Gastric G-Cell Gastrin Producing Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5579

NCIt ⁴⁹ C27444

UMLS ⁷¹ C1333767

Sources

Summaries for Gastric Gastrinoma

MalaCards based summary : Gastric Gastrinoma, also known as gastric gastrin-producing neuroendocrine tumor, is related to gastrinoma and gastritis. An important gene associated with Gastric Gastrinoma is GAST (Gastrin), and among its related pathways/superpathways is Secretion of Hydrochloric Acid in Parietal Cells. Affiliated tissues include small intestine, lung and thyroid.

Sources

Related Diseases for Gastric Gastrinoma

Diseases related to Gastric Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)

#	Related Disease	Score	Top Affiliating Genes
1	gastrinoma	30.2	MEN1 GAST CHGA
2	gastritis	30.0	GAST CHGA ATP4A
3	atrophic gastritis	29.8	MEN1 GAST CHGA
4	zollinger-ellison syndrome	29.1	MEN1 GAST CHGA ATP4A ATP12A
5	autoimmune atrophic gastritis	10.4	GAST CHGA
6	mixed ductal-endocrine carcinoma	10.4	GAST CHGA
7	glucagonoma	10.3	GAST CHGA
8	appendiceal neoplasm	10.3	SPINK5 CHGA
9	tropical sprue	10.3	GAST ATP12A
10	extracranial neuroblastoma	10.3	SPINK5 CHGA
11	meckel diverticulum	10.2	SPINK5 CHGA
12	ureter small cell carcinoma	10.2	ENO2 CHGA
13	vaginal glandular tumor	10.2	ENO2 CHGA
14	small cell carcinoma of the bladder	10.2	ENO2 CHGA
15	urinary bladder small cell neuroendocrine carcinoma	10.2	ENO2 CHGA
16	acinar cell carcinoma	10.2	GAST CHGA
17	appendix carcinoid tumor	10.2	ENO2 CHGA
18	auditory system cancer	10.2	ENO2 CHGA
19	thymus small cell carcinoma	10.2	ENO2 CHGA
20	cauda equina neoplasm	10.2	ENO2 CHGA
21	duodenal benign neoplasm	10.2	ENO2 CHGA
22	ampulla of vater neoplasm	10.2	ENO2 CHGA
23	middle ear adenoma	10.2	ENO2 CHGA
24	nodular ganglioneuroblastoma	10.2	ENO2 CHGA
25	gastric small cell carcinoma	10.2	ENO2 CHGA
26	sensory organ benign neoplasm	10.2	ENO2 CHGA
27	subependymoma	10.2	ENO2 CHGA
28	anal neuroendocrine tumor	10.2	SPINK5 ENO2
29	pineocytoma	10.2	ENO2 CHGA
30	cervical large cell neuroendocrine carcinoma	10.2	ENO2 CHGA
31	large cell neuroendocrine carcinoma	10.2	ENO2 CHGA
32	lung oat cell carcinoma	10.2	ENO2 CHGA
33	cutaneous ganglioneuroma	10.2	ENO2 CHGA
34	ganglioneuroma	10.2	ENO2 CHGA
35	cervix small cell carcinoma	10.2	ENO2 CHGA
36	liver leiomyosarcoma	10.2	ENO2 CHGA
37	prostate neuroendocrine neoplasm	10.2	ENO2 CHGA
38	mediastinal cancer	10.2	ENO2 CHGA
39	pancreatic vasoactive intestinal peptide producing tumor	10.2	ATP4A ATP12A
40	olfactory nerve neoplasm	10.2	ENO2 CHGA
41	cranial nerve malignant neoplasm	10.2	ENO2 CHGA
42	hemangioma of intra-abdominal structure	10.2	ATP4A ATP12A
43	granulosa cell tumor of the ovary	10.2	ENO2 CHGA
44	gastric hemangioma	10.2	ATP4A ATP12A
45	acquired gastric outlet stenosis	10.2	ATP4A ATP12A
46	angiodysplasia of intestine	10.2	ATP4A ATP12A
47	angiodysplasia	10.2	ATP4A ATP12A
48	benzylpenicillin allergy	10.2	ATP4A ATP12A
49	median arcuate ligament syndrome	10.2	ATP4A ATP12A
50	bacterial esophagitis	10.2	ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastric Gastrinoma:

Sources

Symptoms & Phenotypes for Gastric Gastrinoma

Sources

Drugs & Therapeutics for Gastric Gastrinoma

Search Clinical Trials , NIH Clinical Center for Gastric Gastrinoma

Sources

Genetic Tests for Gastric Gastrinoma

Sources

Anatomical Context for Gastric Gastrinoma

MalaCards organs/tissues related to Gastric Gastrinoma:

⁴⁰

Small Intestine, Lung, Thyroid, Cervix, Appendix, Thymus, Colon

Sources

Publications for Gastric Gastrinoma

Articles related to Gastric Gastrinoma:

#	Title	Authors	PMID	Year
1	Gastric gastrinoma. ⁶¹	Liu TH...Yie SF	2517058	1989
2	Gastric gastrinoma and diffuse G cell hyperplasia associated with chronic atrophic gastritis. Endoscopic detection and removal. ⁶¹	Russo A...Solcia E	6250933	1980
3	[Zollinger-Ellison syndrome due to a gastric gastrinoma (author's transl)]. ⁶¹	Soule JC...Bader JP	962485	1976

Sources

Genes for Gastric Gastrinoma

Genes related to Gastric Gastrinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GAST	Gastrin	Protein Coding	5.52	DISEASES inferred ¹⁵
2	CHGA	Chromogranin A	Protein Coding	5.12	DISEASES inferred ¹⁵
3	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	5.1	DISEASES inferred ¹⁵
4	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	4.7	DISEASES inferred ¹⁵
5	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	4.7	DISEASES inferred ¹⁵
6	MEN1	Menin 1	Protein Coding	3.95	DISEASES inferred ¹⁵
7	NPS	Neuropeptide S	Protein Coding	3.66	DISEASES inferred ¹⁵
8	ENO2	Enolase 2	Protein Coding	3.63	DISEASES inferred ¹⁵

Sources

Variations for Gastric Gastrinoma

Sources

Expression for Gastric Gastrinoma

Search GEO for disease gene expression data for Gastric Gastrinoma.

Sources

Pathways for Gastric Gastrinoma

Pathways related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Secretion of Hydrochloric Acid in Parietal Cells ¹	9.32	GAST ATP4A

Sources

GO Terms for Gastric Gastrinoma

Biological processes related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	potassium ion import across plasma membrane	GO:1990573	9.32	ATP4A ATP12A
2	cellular sodium ion homeostasis	GO:0006883	9.26	ATP4A ATP12A
3	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.16	ATP4A ATP12A
4	sodium ion export across plasma membrane	GO:0036376	8.96	ATP4A ATP12A
5	cellular potassium ion homeostasis	GO:0030007	8.62	ATP4A ATP12A

Molecular functions related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP4A ATP12A
2	potassium-transporting ATPase activity	GO:0008556	8.96	ATP4A ATP12A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP4A ATP12A

Sources

Sources for Gastric Gastrinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia