MCID: GST031
MIFTS: 23

Gastric Gastrinoma

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Gastric Gastrinoma

MalaCards integrated aliases for Gastric Gastrinoma:

Name: Gastric Gastrinoma 12 15
Gastric Gastrin-Producing Neuroendocrine Tumor 71
Gastric G-Cell Gastrin Producing Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5579
NCIt 49 C27444
UMLS 71 C1333767

Summaries for Gastric Gastrinoma

MalaCards based summary : Gastric Gastrinoma, also known as gastric gastrin-producing neuroendocrine tumor, is related to gastrinoma and gastritis. An important gene associated with Gastric Gastrinoma is GAST (Gastrin), and among its related pathways/superpathways is Secretion of Hydrochloric Acid in Parietal Cells. Affiliated tissues include small intestine, lung and thyroid.

Related Diseases for Gastric Gastrinoma

Diseases related to Gastric Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 gastrinoma 30.2 MEN1 GAST CHGA
2 gastritis 30.0 GAST CHGA ATP4A
3 atrophic gastritis 29.8 MEN1 GAST CHGA
4 zollinger-ellison syndrome 29.1 MEN1 GAST CHGA ATP4A ATP12A
5 autoimmune atrophic gastritis 10.4 GAST CHGA
6 mixed ductal-endocrine carcinoma 10.4 GAST CHGA
7 glucagonoma 10.3 GAST CHGA
8 appendiceal neoplasm 10.3 SPINK5 CHGA
9 tropical sprue 10.3 GAST ATP12A
10 extracranial neuroblastoma 10.3 SPINK5 CHGA
11 meckel diverticulum 10.2 SPINK5 CHGA
12 ureter small cell carcinoma 10.2 ENO2 CHGA
13 vaginal glandular tumor 10.2 ENO2 CHGA
14 small cell carcinoma of the bladder 10.2 ENO2 CHGA
15 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 CHGA
16 acinar cell carcinoma 10.2 GAST CHGA
17 appendix carcinoid tumor 10.2 ENO2 CHGA
18 auditory system cancer 10.2 ENO2 CHGA
19 thymus small cell carcinoma 10.2 ENO2 CHGA
20 cauda equina neoplasm 10.2 ENO2 CHGA
21 duodenal benign neoplasm 10.2 ENO2 CHGA
22 ampulla of vater neoplasm 10.2 ENO2 CHGA
23 middle ear adenoma 10.2 ENO2 CHGA
24 nodular ganglioneuroblastoma 10.2 ENO2 CHGA
25 gastric small cell carcinoma 10.2 ENO2 CHGA
26 sensory organ benign neoplasm 10.2 ENO2 CHGA
27 subependymoma 10.2 ENO2 CHGA
28 anal neuroendocrine tumor 10.2 SPINK5 ENO2
29 pineocytoma 10.2 ENO2 CHGA
30 cervical large cell neuroendocrine carcinoma 10.2 ENO2 CHGA
31 large cell neuroendocrine carcinoma 10.2 ENO2 CHGA
32 lung oat cell carcinoma 10.2 ENO2 CHGA
33 cutaneous ganglioneuroma 10.2 ENO2 CHGA
34 ganglioneuroma 10.2 ENO2 CHGA
35 cervix small cell carcinoma 10.2 ENO2 CHGA
36 liver leiomyosarcoma 10.2 ENO2 CHGA
37 prostate neuroendocrine neoplasm 10.2 ENO2 CHGA
38 mediastinal cancer 10.2 ENO2 CHGA
39 pancreatic vasoactive intestinal peptide producing tumor 10.2 ATP4A ATP12A
40 olfactory nerve neoplasm 10.2 ENO2 CHGA
41 cranial nerve malignant neoplasm 10.2 ENO2 CHGA
42 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
43 granulosa cell tumor of the ovary 10.2 ENO2 CHGA
44 gastric hemangioma 10.2 ATP4A ATP12A
45 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
46 angiodysplasia of intestine 10.2 ATP4A ATP12A
47 angiodysplasia 10.2 ATP4A ATP12A
48 benzylpenicillin allergy 10.2 ATP4A ATP12A
49 median arcuate ligament syndrome 10.2 ATP4A ATP12A
50 bacterial esophagitis 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastric Gastrinoma:



Diseases related to Gastric Gastrinoma

Symptoms & Phenotypes for Gastric Gastrinoma

Drugs & Therapeutics for Gastric Gastrinoma

Search Clinical Trials , NIH Clinical Center for Gastric Gastrinoma

Genetic Tests for Gastric Gastrinoma

Anatomical Context for Gastric Gastrinoma

MalaCards organs/tissues related to Gastric Gastrinoma:

40
Small Intestine, Lung, Thyroid, Cervix, Appendix, Thymus, Colon

Publications for Gastric Gastrinoma

Articles related to Gastric Gastrinoma:

# Title Authors PMID Year
1
Gastric gastrinoma. 61
2517058 1989
2
Gastric gastrinoma and diffuse G cell hyperplasia associated with chronic atrophic gastritis. Endoscopic detection and removal. 61
6250933 1980
3
[Zollinger-Ellison syndrome due to a gastric gastrinoma (author's transl)]. 61
962485 1976

Variations for Gastric Gastrinoma

Expression for Gastric Gastrinoma

Search GEO for disease gene expression data for Gastric Gastrinoma.

Pathways for Gastric Gastrinoma

Pathways related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.32 GAST ATP4A

GO Terms for Gastric Gastrinoma

Biological processes related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
2 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 8.96 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.62 ATP4A ATP12A

Molecular functions related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Gastric Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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