Gastric Gastrinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Gastric Gastrinoma

MalaCards integrated aliases for Gastric Gastrinoma:

Name: Gastric Gastrinoma ¹² ¹⁵

Gastric Gastrin-Producing Neuroendocrine Tumor ⁷¹

Gastric G-Cell Gastrin Producing Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5579

NCIt ⁴⁹ C27444

UMLS ⁷¹ C1333767

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Summaries for Gastric Gastrinoma

MalaCards based summary : Gastric Gastrinoma, also known as gastric gastrin-producing neuroendocrine tumor, is related to atrophic gastritis and gastrinoma. An important gene associated with Gastric Gastrinoma is GAST (Gastrin), and among its related pathways/superpathways are Gastric acid production and Secretion of Hydrochloric Acid in Parietal Cells.

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Related Diseases for Gastric Gastrinoma

Diseases related to Gastric Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)

#	Related Disease	Score	Top Affiliating Genes
1	atrophic gastritis	30.0	MEN1 GAST CHGA
2	gastrinoma	29.7	SCT MEN1 GAST CHGA
3	gastritis	29.4	SCT GAST CHGA ATP4A
4	zollinger-ellison syndrome	28.7	SCT MEN1 GAST CHGA ATP4A ATP12A
5	autoimmune atrophic gastritis	10.4	GAST CHGA
6	mixed ductal-endocrine carcinoma	10.4	GAST CHGA
7	esophageal neuroendocrine tumor	10.3	SPINK5 CHGA
8	appendiceal neoplasm	10.3	SPINK5 CHGA
9	postgastrectomy syndrome	10.3	GAST ATP12A
10	meckel diverticulum	10.3	SPINK5 CHGA
11	vagus nerve disease	10.2	ATP4A ATP12A
12	hemangioma of intra-abdominal structure	10.2	ATP4A ATP12A
13	acquired gastric outlet stenosis	10.2	ATP4A ATP12A
14	breast neuroendocrine neoplasm	10.2	ENO2 CHGA
15	angiodysplasia of intestine	10.2	ATP4A ATP12A
16	benzylpenicillin allergy	10.2	ATP4A ATP12A
17	vaginal glandular tumor	10.2	ENO2 CHGA
18	penicillin allergy	10.2	ATP4A ATP12A
19	bacterial esophagitis	10.2	ATP4A ATP12A
20	lingual goiter	10.2	ATP4A ATP12A
21	cascade stomach	10.2	ATP4A ATP12A
22	gastrojejunal ulcer	10.2	ATP4A ATP12A
23	median arcuate ligament syndrome	10.2	ATP4A ATP12A
24	small cell carcinoma of the bladder	10.2	ENO2 CHGA
25	laryngeal tuberculosis	10.2	ATP4A ATP12A
26	fungal esophagitis	10.2	ATP4A ATP12A
27	ureter transitional cell carcinoma	10.2	ENO2 CHGA
28	dieulafoy lesion	10.2	ATP4A ATP12A
29	esophagus melanoma	10.2	ATP4A ATP12A
30	auditory system benign neoplasm	10.2	ENO2 CHGA
31	emphysematous cholecystitis	10.2	ATP4A ATP12A
32	appendix carcinoid tumor	10.2	ENO2 CHGA
33	auditory system cancer	10.2	ENO2 CHGA
34	necrotizing gastritis	10.2	ATP4A ATP12A
35	cervix erosion	10.2	ATP4A ATP12A
36	cauda equina neoplasm	10.2	ENO2 CHGA
37	pneumatosis cystoides intestinalis	10.2	ATP4A ATP12A
38	duodenal benign neoplasm	10.2	ENO2 CHGA
39	ampulla of vater neoplasm	10.2	ENO2 CHGA
40	urinary bladder small cell neuroendocrine carcinoma	10.2	ENO2 CHGA
41	ureter small cell carcinoma	10.2	ENO2 CHGA
42	superior mesenteric artery syndrome	10.2	ATP4A ATP12A
43	middle ear adenoma	10.2	ENO2 CHGA
44	chronic laryngitis	10.2	ATP4A ATP12A
45	nodular ganglioneuroblastoma	10.2	ENO2 CHGA
46	laryngitis	10.2	ATP4A ATP12A
47	cefuroxime allergy	10.2	ATP4A ATP12A
48	polyposis, skin pigmentation, alopecia, and fingernail changes	10.2	ATP4A ATP12A
49	anal neuroendocrine tumor	10.2	SPINK5 ENO2
50	chronic intestinal vascular insufficiency	10.2	ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastric Gastrinoma:

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Symptoms & Phenotypes for Gastric Gastrinoma

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Drugs & Therapeutics for Gastric Gastrinoma

Search Clinical Trials , NIH Clinical Center for Gastric Gastrinoma

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Genetic Tests for Gastric Gastrinoma

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Anatomical Context for Gastric Gastrinoma

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Publications for Gastric Gastrinoma

Articles related to Gastric Gastrinoma:

#	Title	Authors	PMID	Year
1	Gastric gastrinoma. ⁶¹	Liu TH...Yie SF	2517058	1989
2	Gastric gastrinoma and diffuse G cell hyperplasia associated with chronic atrophic gastritis. Endoscopic detection and removal. ⁶¹	Russo A...Solcia E	6250933	1980
3	[Zollinger-Ellison syndrome due to a gastric gastrinoma (author's transl)]. ⁶¹	Soule JC...Bader JP	962485	1976

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Genes for Gastric Gastrinoma

Genes related to Gastric Gastrinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GAST	Gastrin	Protein Coding	5.71	DISEASES inferred ¹⁵
2	CHGA	Chromogranin A	Protein Coding	5.04	DISEASES inferred ¹⁵
3	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	4.97	DISEASES inferred ¹⁵
4	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	4.95	DISEASES inferred ¹⁵
5	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	4.95	DISEASES inferred ¹⁵
6	MEN1	Menin 1	Protein Coding	4.69	DISEASES inferred ¹⁵
7	SCT	Secretin	Protein Coding	4.33	DISEASES inferred ¹⁵
8	NPS	Neuropeptide S	Protein Coding	3.55	DISEASES inferred ¹⁵
9	ENO2	Enolase 2	Protein Coding	3.54	DISEASES inferred ¹⁵

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Variations for Gastric Gastrinoma

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Expression for Gastric Gastrinoma

Search GEO for disease gene expression data for Gastric Gastrinoma.

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Pathways for Gastric Gastrinoma

Pathways related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastric acid production ¹	9.8	SCT GAST
2	Secretion of Hydrochloric Acid in Parietal Cells ¹	9.32	GAST ATP4A

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GO Terms for Gastric Gastrinoma

Biological processes related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	potassium ion import across plasma membrane	GO:1990573	9.32	ATP4A ATP12A
2	cellular sodium ion homeostasis	GO:0006883	9.26	ATP4A ATP12A
3	sodium ion export across plasma membrane	GO:0036376	9.16	ATP4A ATP12A
4	cellular potassium ion homeostasis	GO:0030007	8.96	ATP4A ATP12A
5	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	8.62	ATP4A ATP12A

Molecular functions related to Gastric Gastrinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP4A ATP12A
2	potassium-transporting ATPase activity	GO:0008556	8.96	ATP4A ATP12A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP4A ATP12A

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Sources for Gastric Gastrinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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⁸ Cochrane Library

⁹ Cosmic

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia