MCID: GST006
MIFTS: 33

Gastric Leiomyoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Leiomyoma

MalaCards integrated aliases for Gastric Leiomyoma:

Name: Gastric Leiomyoma 12 15 73
Leiomyoma of the Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10087
NCIt 50 C3876
UMLS 73 C0238440

Summaries for Gastric Leiomyoma

MalaCards based summary : Gastric Leiomyoma, also known as leiomyoma of the stomach, is related to leiomyoma and papillary ependymoma. An important gene associated with Gastric Leiomyoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Pathways in cancer and DNA Damage. Affiliated tissues include pituitary, pancreas and thyroid, and related phenotype is Increased viability with MLN4924 (a NAE inhibitor).

Related Diseases for Gastric Leiomyoma

Diseases related to Gastric Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 10.8
2 papillary ependymoma 10.1 KRT18 CHGA
3 pleomorphic xanthoastrocytoma 10.1 MGMT CHGA
4 appendix carcinoid tumor 10.0 MSH6 MLH1
5 glycogen storage disease vi 10.0 GCG CHGA
6 adenosquamous colon carcinoma 10.0 MSH6 MLH1
7 colorectal cancer 5 10.0 MSH6 MLH1
8 pancreatic cystadenoma 10.0 GCG CHGA
9 sebaceous adenoma 10.0 MSH6 MLH1
10 leiomyoma cutis 10.0 FH CALD1
11 gastrointestinal system benign neoplasm 10.0 GCG CHGA
12 lynch syndrome i 10.0 MSH6 MLH1
13 sebaceous adenocarcinoma 10.0 MSH6 MLH1
14 skin sarcoma 10.0 FH CALD1
15 muir-torre syndrome 10.0 MSH6 MLH1
16 skin benign neoplasm 10.0 MSH6 MLH1
17 small intestine cancer 10.0 MSH6 MLH1
18 mismatch repair cancer syndrome 10.0 MSH6 MLH1
19 leiomyosarcoma 10.0
20 adenoma 10.0
21 colorectal cancer, hereditary nonpolyposis, type 5 10.0 MSH6 MLH1
22 nephrogenic adenofibroma 10.0 KRT18 CALD1
23 uterine anomalies 9.9 MSH6 MLH1
24 colonic disease 9.9 MSH6 MLH1
25 cell type benign neoplasm 9.9 MLH1 FH CHGA
26 familial adenomatous polyposis 9.9 MSH6 MSH3 MLH1
27 colorectal adenocarcinoma 9.9 MSH6 MLH1
28 adenocarcinoma 9.9
29 bizarre leiomyoma 9.9
30 hereditary breast ovarian cancer syndrome 9.9 MSH6 MLH1
31 cecum adenocarcinoma 9.8 MSH6 MLH1 CHGA
32 intestinal disease 9.8 MSH6 MLH1 GCG
33 endocrine gland cancer 9.8 MLH1 GCG CHGA
34 intussusception 9.8
35 thrombophilia due to thrombin defect 9.8
36 thyroid cancer, nonmedullary, 1 9.8
37 paraganglioma 9.8
38 thrombosis 9.8
39 granular cell tumor 9.8
40 pituitary adenoma 9.8
41 leiomyomatosis 9.8
42 multicentric papillary thyroid carcinoma 9.8
43 amyloidosis 9.8
44 pancreatic adenoma 9.8
45 multiple endocrine neoplasia 9.8
46 adenoma of the pancreas 9.8
47 female reproductive system disease 9.8 MSH6 MLH1
48 gastric adenocarcinoma 9.8 MLH1 MGMT CHGA
49 lynch syndrome 9.8 MSH6 MSH3 MLH1 MGMT
50 large intestine cancer 9.8 MSH6 MSH3 MLH1 MGMT

Graphical network of the top 20 diseases related to Gastric Leiomyoma:



Diseases related to Gastric Leiomyoma

Symptoms & Phenotypes for Gastric Leiomyoma

GenomeRNAi Phenotypes related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MGMT MLH1 MSH3 MSH6

Drugs & Therapeutics for Gastric Leiomyoma

Search Clinical Trials , NIH Clinical Center for Gastric Leiomyoma

Genetic Tests for Gastric Leiomyoma

Anatomical Context for Gastric Leiomyoma

MalaCards organs/tissues related to Gastric Leiomyoma:

41
Pituitary, Pancreas, Thyroid, Skin, Colon, Small Intestine, Appendix

Publications for Gastric Leiomyoma

Articles related to Gastric Leiomyoma:

(show top 50) (show all 107)
# Title Authors Year
1
Synchronous gastric leiomyoma and intramuscular abdominal wall granular cell tumor with similar imaging features: A case report. ( 29529541 )
2018
2
Ulcerated gastric leiomyoma causing massive upper gastrointestinal bleeding: A case report. ( 29725533 )
2018
3
Aseptic cerebral venous thrombosis associated with a gastric leiomyoma. ( 29560682 )
2017
4
Intragastric Single-Incision Laparoscopic Surgery for Gastric Leiomyoma: A Stepwise Approach. ( 28466402 )
2017
5
Endoscopic dissection of a symptomatic giant gastric leiomyoma arising from the muscularis propria. ( 28355652 )
2017
6
Partial gastrectomy for resection of a gastric leiomyoma in a guinea pig (Cavia porcellus). ( 27901456 )
2016
7
Laparoscopic Transgastric Enucleation of a Gastric Leiomyoma near the Esophagogastric Junction and Concomitant Sleeve Gastrectomy: Video Report. ( 26883931 )
2016
8
Gastric leiomyoma in a child with Gorlin-Goltz syndrome: First pediatric case. ( 26567923 )
2015
9
Epigenetic alterations in a gastric leiomyoma. ( 25544907 )
2014
10
Laparoscopic-Assisted Endoscopic Resection of a Gastric Leiomyoma. ( 25642406 )
2014
11
Intragastric endoscopic assisted single incision surgery for gastric leiomyoma of the esophagogastric junction. ( 24416603 )
2013
12
Gastric leiomyoma and hyperplastic polyposis coli in a patient with multiple cutaneous and uterine leiomyomatosis. ( 22713448 )
2012
13
Robotic-assisted laparoscopic wedge resection of a gastric leiomyoma with intraoperative ultrasound localization. ( 21919811 )
2011
14
Simultaneous adenocarcinoma and leiomyoma of the stomach presenting as a collision tumor. ( 26192793 )
2009
15
Gastric leiomyoma in a free-living Atlantic bottlenosed dolphin (Tursiops truncatus). ( 17259457 )
2007
16
Laparoscopic wedge resection of gastric leiomyoma. ( 17212898 )
2006
17
Laparoscopic wedge resection of gastric leiomyoma. ( 14974670 )
2004
18
Gastric leiomyoma. Is there an association with Helicobacter pylori? ( 15573227 )
2004
19
Symptomatic gastric leiomyoma mimicking giant gastric polyp: endoscopic diagnosis and removal. ( 15368793 )
2004
20
Gastric leiomyoma presenting as gastric volvulus. ( 15030039 )
2003
21
Laparoscopic intragastric resection of gastric leiomyoma using needlescopic instruments. Case report. ( 11409411 )
2001
22
Laparoscopic wedge resection of a gastric leiomyoma. ( 11443434 )
2001
23
Laparoscopic intragastric resection of gastric leiomyoma close to the cardia using a flexible endocutter intraluminally. ( 10636561 )
1999
24
Gastroduodenal intussusception secondary to a gastric leiomyoma resulting in an ulceration. ( 10344450 )
1999
25
Surgical treatment of gastric leiomyoma in a dog. ( 10197242 )
1999
26
An undescribed coexistence of a subserosal exophytic gastric leiomyoma with a serous microcystic pancreatic adenoma. ( 10670168 )
1999
27
Laparoscopic management of a gastric perforation after snare removal of a gastric leiomyoma. ( 9689521 )
1998
28
Combined laparoscopic treatment of gastric leiomyoma and gallstones. ( 9830549 )
1998
29
Posterior wall gastric leiomyoma: endoscopic tattooing facilitates laparoscopic resection. ( 9876718 )
1998
30
Resection of a gastric leiomyoma using combined laparoscopic and gastroscopic approach. ( 9079612 )
1997
31
Cystic gastric leiomyoma--a diagnostic pitfall. ( 9396182 )
1997
32
Laparoscopic intragastric surgery for gastric leiomyoma. ( 9079613 )
1997
33
Laparoscopic resection of posterior gastric leiomyoma. ( 9079609 )
1997
34
Calcified gastric leiomyoma: a rare cause of calcification in the abdomen. ( 8583116 )
1995
35
Combined laparoscopic and endoscopic approach to resection of gastric leiomyoma. ( 7612942 )
1995
36
Ossified gastric leiomyoma in a child: a case report. ( 7761163 )
1995
37
Laparoscopic gastric resection for gastric leiomyoma. ( 7992156 )
1994
38
Case report: simple liver cyst masquerading as a gastric leiomyoma--a diagnostic pitfall. ( 8243013 )
1993
39
Endoscopic closure of a perforation using metallic clips after snare excision of a gastric leiomyoma. ( 8495838 )
1993
40
Large polypoid gastric leiomyoma with intermittent duodenal prolapse. ( 8253656 )
1993
41
Kinking of splenic artery mimicking gastric leiomyoma. ( 8262001 )
1993
42
Gastric leiomyoma: an unusual presentation. ( 1561201 )
1992
43
Injection therapy for bleeding gastric leiomyoma. ( 1473688 )
1992
44
Leiomyomatous tumors: presentation of a giant gastric leiomyoma and a review of the literature. ( 2668809 )
1989
45
Cystic leiomyoma of the stomach. ( 2599838 )
1989
46
Ossified leiomyoma of the stomach: demonstration on computed tomography. ( 2914197 )
1989
47
Enucleation of a gastric leiomyoma by a combined laser and snare electrocutting technique. ( 3366329 )
1988
48
Technetium-99m labeled RBC imaging in gastrointestinal bleeding from gastric leiomyoma. ( 3258215 )
1988
49
[X-ray computed tomographic aspect of gastric leiomyoma. Apropos of a case]. ( 3560033 )
1987
50
Drug-induced bleeding of gastric leiomyoma. ( 3495170 )
1987

Variations for Gastric Leiomyoma

Expression for Gastric Leiomyoma

Search GEO for disease gene expression data for Gastric Leiomyoma.

Pathways for Gastric Leiomyoma

GO Terms for Gastric Leiomyoma

Cellular components related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.8 MLH1 MSH3 MSH6

Biological processes related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 MGMT MLH1 MSH3 MSH6
2 DNA repair GO:0006281 9.71 MGMT MLH1 MSH3 MSH6
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.52 MLH1 MSH6
4 reciprocal meiotic recombination GO:0007131 9.51 MLH1 MSH3
5 negative regulation of DNA recombination GO:0045910 9.48 MSH3 MSH6
6 somatic hypermutation of immunoglobulin genes GO:0016446 9.46 MLH1 MSH6
7 isotype switching GO:0045190 9.43 MLH1 MSH6
8 positive regulation of helicase activity GO:0051096 9.37 MSH3 MSH6
9 replication fork arrest GO:0043111 9.32 MSH3 MSH6
10 maintenance of DNA repeat elements GO:0043570 9.26 MSH3 MSH6
11 meiotic mismatch repair GO:0000710 9.16 MSH3 MSH6
12 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MLH1 MSH6
13 mismatch repair GO:0006298 8.8 MLH1 MSH3 MSH6

Molecular functions related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.61 MLH1 MSH3 MSH6
2 damaged DNA binding GO:0003684 9.4 MSH3 MSH6
3 DNA-dependent ATPase activity GO:0008094 9.37 MSH3 MSH6
4 oxidized purine DNA binding GO:0032357 9.32 MSH3 MSH6
5 single thymine insertion binding GO:0032143 9.26 MSH3 MSH6
6 single guanine insertion binding GO:0032142 9.16 MSH3 MSH6
7 mismatched DNA binding GO:0030983 9.13 MLH1 MSH3 MSH6
8 guanine/thymine mispair binding GO:0032137 8.8 MLH1 MSH3 MSH6

Sources for Gastric Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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