MCID: GST036
MIFTS: 31

Gastric Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Leiomyosarcoma

MalaCards integrated aliases for Gastric Leiomyosarcoma:

Name: Gastric Leiomyosarcoma 12 15
Leiomyosarcoma of Stomach 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5280
NCIt 50 C27200
SNOMED-CT 67 447785000
UMLS 70 C0744295

Summaries for Gastric Leiomyosarcoma

MalaCards based summary : Gastric Leiomyosarcoma, also known as leiomyosarcoma of stomach, is related to paragangliomas 1 and carney triad. An important gene associated with Gastric Leiomyosarcoma is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are Prion disease and Carbon metabolism. Affiliated tissues include smooth muscle, liver and pancreas, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Gastric Leiomyosarcoma

Diseases related to Gastric Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 30.8 SDHD SDHC SDHB SDHA
2 carney triad 30.3 SDHD SDHC SDHB SDHA PDGFRA KIT
3 paraganglioma 28.5 SDHD SDHC SDHB SDHAF2 SDHA KIT
4 chondroma 27.9 SDHD SDHC SDHB SDHAF2 SDHA PDGFRA
5 gastrointestinal stromal tumor 27.8 SDHD SDHC SDHB SDHA PDGFRA KIT
6 leiomyosarcoma 10.9
7 sporadic pheochromocytoma/secreting paraganglioma 10.2 SDHD SDHB
8 plethora of newborn 10.2 SDHD SDHB
9 reticular perineurioma 10.2 PDGFRA KIT
10 laryngeal small cell carcinoma 10.2 PDGFRA KIT
11 pulmonary vein stenosis 10.2 PDGFRA KIT
12 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.1 PDGFRA KIT
13 hypereosinophilic syndrome, idiopathic 10.1 PDGFRA KIT
14 sm-ahnmd 10.1 PDGFRA KIT
15 cranial nerve palsy 10.1 SDHD SDHB
16 nonsyndromic paraganglioma 10.1
17 endometrial small cell carcinoma 10.1 PDGFRA KIT
18 autonomic nervous system benign neoplasm 10.1 SDHD SDHB
19 peripheral nervous system benign neoplasm 10.1 SDHD SDHB
20 conventional fibrosarcoma 10.1 PDGFRA KIT
21 small intestine leiomyosarcoma 10.1 KIT ANO1
22 gastric liposarcoma 10.1 KIT ANO1
23 gliofibroma 10.1 PDGFRA KIT
24 jejunal neoplasm 10.1 KIT ANO1
25 liver leiomyoma 10.1 KIT ANO1
26 esophageal adenoid cystic carcinoma 10.1 KIT ANO1
27 gastric hemangioma 10.1 KIT ANO1
28 retroperitoneal leiomyosarcoma 10.1 KIT ANO1
29 glomus tumor 10.1 SDHD SDHB
30 endobronchial leiomyoma 10.1 KIT ANO1
31 fibrosarcoma of bone 10.1 PDGFRA KIT
32 mucinous stomach adenocarcinoma 10.1 KIT ANO1
33 pleomorphic liposarcoma 10.1 PDGFRA KIT
34 retroperitoneal sarcoma 10.1 KIT ANO1
35 sarcomatous intrahepatic cholangiocarcinoma 10.1 KIT ANO1
36 prostate stromal sarcoma 10.1 KIT ANO1
37 bladder leiomyoma 10.1 KIT ANO1
38 small intestine benign neoplasm 10.1 KIT ANO1
39 myelodysplastic/myeloproliferative neoplasm 10.1 PDGFRA KIT
40 active peptic ulcer disease 10.1 KIT ANO1
41 plexiform neurofibroma 10.1 PDGFRA KIT
42 colon leiomyoma 10.1 KIT ANO1
43 chronic eosinophilic leukemia 10.1 PDGFRA KIT
44 large cell neuroendocrine carcinoma 10.1 PDGFRA KIT
45 perivascular tumor 10.1 KIT ANO1
46 intussusception 10.1 KIT ANO1
47 desmoid tumor 10.1 PDGFRA KIT
48 neurofibromatosis, type ii 10.1 SDHD SDHB
49 cavernous hemangioma 10.1 PDGFRA KIT
50 smooth muscle tumor 10.1 KIT ANO1

Graphical network of the top 20 diseases related to Gastric Leiomyosarcoma:



Diseases related to Gastric Leiomyosarcoma

Symptoms & Phenotypes for Gastric Leiomyosarcoma

MGI Mouse Phenotypes related to Gastric Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 ANO1 KIT PDGFRA SDHA SDHAF2 SDHC
2 mortality/aging MP:0010768 9.56 ANO1 KIT PDGFRA SDHA SDHAF2 SDHB
3 neoplasm MP:0002006 9.02 KIT PDGFRA SDHB SDHC SDHD

Drugs & Therapeutics for Gastric Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Gastric Leiomyosarcoma

Genetic Tests for Gastric Leiomyosarcoma

Anatomical Context for Gastric Leiomyosarcoma

MalaCards organs/tissues related to Gastric Leiomyosarcoma:

40
Smooth Muscle, Liver, Pancreas, Colon, Thyroid, T Cells

Publications for Gastric Leiomyosarcoma

Articles related to Gastric Leiomyosarcoma:

(show top 50) (show all 199)
# Title Authors PMID Year
1
Carney triad: A case report, characteristics and literature review of this rare entity. 61
33422846 2021
2
Epstein-Barr virus negative smooth muscle neoplasm of the stomach in a young woman. 61
32565203 2021
3
Primary Gastric Leiomyosarcoma-a Rarely Encountered Clinical Entity. 61
33169323 2020
4
An Unusual Case of Gastric Leiomyosarcoma Presenting as a Giant Polyp. 61
32473349 2020
5
Primary Gastric Leiomyosarcoma: a Case Report and Review of the Literature. 61
31227984 2020
6
Gastric Leiomyosarcoma Unmasked by Bleeding From a Percutaneous Endoscopic Gastrostomy Tube. 61
32309495 2020
7
Long lasting response of trabectedin in patient with gastric leiomyosarcoma with liver metastasis: an update to previous report. 61
31915533 2019
8
Leiomyosarcoma of the stomach: A case report. 61
31750340 2019
9
Multimodality palliative treatment with transarterial chemoembolization and high-intensity focused ultrasound for gastric leiomyosarcoma multiple liver metastasis pain: A case report. 61
31574868 2019
10
Gastric leiomyosarcoma revealed by bleeding. 61
30391271 2018
11
Gastric leiomyosarcoma and diagnostic pitfalls: a case report. 61
30119659 2018
12
Leiomyosarcoma of the stomach treated by endoscopic submucosal dissection. 61
29500609 2018
13
A case of gastric leiomyosarcoma in a domestic shorthair cat. 61
30559970 2018
14
Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. 61
28426279 2017
15
[A case of gastric leiomyosarcoma with multiple metastases]. 61
25716714 2015
16
[Gastric leiomyosarcoma simulating splenic hilum tumor: report of a case]. 61
26526400 2015
17
Gastric leiomyosarcoma as a rare cause of gastric outlet obstruction and perforation: a case report. 61
25069607 2014
18
A case of incomplete Carney's triad. 61
24867050 2014
19
Primary leiomyosarcomas of the gastrointestinal tract in the post-gastrointestinal stromal tumor era. 61
22917807 2012
20
[Gastric leiomyosarcoma: case report and review of literature]. 61
23007823 2012
21
Primary leiomyosarcoma of the pancreas. 61
22319744 2011
22
Cardiac paraganglioma and gastrointestinal stromal tumor: a pediatric case of Carney-Stratakis syndrome. 61
22051283 2011
23
Clinical, radiologic and pathologic characteristics of the Carney triad: a case report and literature review. 61
20705254 2010
24
Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation. 61
19432672 2009
25
Primary gastric leiomyosarcoma in young revealed by a massive hematemesis. 61
19728181 2009
26
Intramucosal leiomyosarcoma of the stomach following hereditary retinoblastoma in childhood - a case report and review of the literature. 61
19077296 2008
27
Unusual acute onset of pedunculated extragastric leiomyosarcoma. Case report. 61
17626770 2007
28
Carney's triad: case report and review. 61
19089668 2007
29
Leiomyosarcoma of stomach: a case report. 61
18603965 2006
30
Hemoperitoneum secondary to spontaneous rupture of metastatic gastric leiomyosarcoma of the liver: report of a case. 61
16830295 2006
31
[Combined multiple organ resection in 16 patients with adenocarcinoma of the body or tail of the pancreas]. 61
16274034 2005
32
Interventional radiology in Carney triad. 61
15108016 2005
33
Pheochromocytoma of the organ of Zuckerkandl. Unusually small lesion detected with magnetic resonance imaging. 61
15756364 2005
34
[Gastric leiomyosarcoma]. 61
15692409 2004
35
Malignant tumor, of the gastrointestinal stromal tumor type, in the greater omentum. 61
14614607 2003
36
[Simultaneous development of factor V inhibitor and autoimmune thrombocytopenia in a patient with dermatomyositis]. 61
12607994 2002
37
[Resection for pulmonary metastasis of gastrointestinal stromal tumor of the stomach at 10 years after gastrectomy; report of a case]. 61
12233115 2002
38
Canine gastric adenocarcinoma and leiomyosarcoma: a retrospective study of 21 cases (1986-1999) and literature review. 61
11908834 2002
39
Multifocal soft-tissue metastases of gastric leiomyosarcoma. 61
11880915 2002
40
[Hepatic actinomycosis associated with gastric leiomyosarcoma. A case report]. 61
11938055 2002
41
Gastrointestinal stromal tumor of the stomach diagnosed preoperatively. 61
11598631 2001
42
[Radiology of gastrointestinal stromal tumors (GIST) and a case of Carney syndrome]. 61
10778462 2000
43
[Carney's triad: update and report of one case]. 61
10671723 2000
44
Hemorrhagic gastric glomus tumor mimicks a leiomyosarcoma on both transabdominal and endoscopic ultrasonography: case report. 61
10695223 1999
45
Gastric leiomyosarcoma presenting as a sentinel hemorrhage. 61
10578561 1999
46
Gastric leiomyosarcoma presenting as severe iron-deficiency anaemia. 61
10468006 1999
47
Gastrocolic fistula due to adenocarcinoma of the colon: simulation of primary gastric leiomyosarcoma on CT. 61
10665346 1999
48
A case of the Carney triad. 61
15251665 1999
49
CT of gastric leiomyosarcoma: patterns of involvement. 61
10430139 1999
50
Leiomyosarcoma of the gastric cardia and fundus. 61
10418174 1999

Variations for Gastric Leiomyosarcoma

Expression for Gastric Leiomyosarcoma

Search GEO for disease gene expression data for Gastric Leiomyosarcoma.

Pathways for Gastric Leiomyosarcoma

GO Terms for Gastric Leiomyosarcoma

Cellular components related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.65 SDHD SDHC SDHB SDHAF2 SDHA
2 mitochondrial inner membrane GO:0005743 9.46 SDHD SDHC SDHB SDHA
3 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.73 SDHD SDHC SDHB SDHA
2 hematopoietic progenitor cell differentiation GO:0002244 9.48 PDGFRA KIT
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.46 PDGFRA KIT
4 electron transport chain GO:0022900 9.43 SDHC SDHB SDHA
5 aerobic respiration GO:0009060 9.4 SDHC SDHB
6 respiratory electron transport chain GO:0022904 9.37 SDHB SDHA
7 tricarboxylic acid cycle GO:0006099 9.35 SDHD SDHC SDHB SDHAF2 SDHA
8 positive regulation of phospholipase C activity GO:0010863 9.32 PDGFRA KIT
9 succinate metabolic process GO:0006105 9.16 SDHB SDHA
10 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHC SDHAF2 SDHA

Molecular functions related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.37 PDGFRA KIT
2 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHC SDHA
3 ubiquinone binding GO:0048039 9.26 SDHD SDHB
4 electron transfer activity GO:0009055 9.26 SDHD SDHC SDHB SDHA
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.16 SDHB SDHA
6 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Gastric Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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