MCID: GST036
MIFTS: 32

Gastric Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Leiomyosarcoma

MalaCards integrated aliases for Gastric Leiomyosarcoma:

Name: Gastric Leiomyosarcoma 12 15
Leiomyosarcoma of Stomach 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5280
NCIt 50 C27200
UMLS 73 C0744295

Summaries for Gastric Leiomyosarcoma

MalaCards based summary : Gastric Leiomyosarcoma, also known as leiomyosarcoma of stomach, is related to carney triad and leiomyosarcoma. An important gene associated with Gastric Leiomyosarcoma is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are Immune response IFN alpha/beta signaling pathway and Central carbon metabolism in cancer. Affiliated tissues include liver, lung and bone, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Gastric Leiomyosarcoma

Diseases related to Gastric Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 carney triad 31.9 KIT PDGFRA SDHD
2 leiomyosarcoma 30.8 ENO2 IGF2 KIT PDGFRA
3 paraganglioma 30.0 ENO2 SDHD
4 paragangliomas 1 11.2
5 neurofibroma 10.2 KIT PDGFRA
6 neurofibromatosis, type i 10.2 KIT PDGFRA
7 reticular perineurioma 10.2 KIT PDGFRA
8 sm-ahnmd 10.2 KIT PDGFRA
9 desmoid tumor 10.2 KIT PDGFRA
10 hypereosinophilic syndrome, idiopathic 10.2 KIT PDGFRA
11 lung adenoid cystic carcinoma 10.2 KIT PDGFRA
12 pulmonary vein stenosis 10.2 KIT PDGFRA
13 chronic eosinophilic leukemia 10.2 KIT PDGFRA
14 mesenchymal cell neoplasm 10.2 KIT PDGFRA
15 undifferentiated pleomorphic sarcoma 10.2 KIT PDGFRA
16 fibrosarcoma of bone 10.1 KIT PDGFRA
17 embryoma 10.1 IGF2 KIT
18 piebald trait 10.1 KIT PDGFRA
19 congenital mesoblastic nephroma 10.1 IGF2 KIT
20 cutaneous ganglioneuroma 10.1 ENO2 KIT
21 plexiform schwannoma 10.1 ENO2 KIT
22 cavernous hemangioma 10.1 KIT PDGFRA
23 rete testis adenocarcinoma 10.1 ENO2 KIT
24 systemic mastocytosis 10.1 KIT PDGFRA
25 angiomyoma 10.1 ENO2 KIT
26 adenosquamous lung carcinoma 10.1 ENO2 PDGFRA
27 prostate small cell carcinoma 10.1 ENO2 KIT
28 mastocytosis 10.1 KIT PDGFRA
29 ileum cancer 10.1 ENO2 PDGFRA
30 meningeal melanocytoma 10.1 ENO2 YARS
31 rete testis neoplasm 10.1 ENO2 KIT
32 cerebral neuroblastoma 10.1 ENO2 IGF2
33 mixed cell type cancer 10.1 ENO2 KIT
34 large cell neuroendocrine carcinoma 10.1 ENO2 KIT
35 myeloproliferative neoplasm 10.1 KIT PDGFRA
36 spinal meningioma 10.1 ENO2 IGF2
37 dysgerminoma of ovary 10.1 ENO2 KIT
38 spinal canal and spinal cord meningioma 10.1 ENO2 IGF2
39 dysgerminoma 10.1 ENO2 KIT
40 dermatofibrosarcoma protuberans 10.1 KIT PDGFRA
41 nervous system benign neoplasm 10.1 ENO2 KIT
42 chondroma 10.1
43 nonsyndromic paraganglioma 10.1
44 connective tissue cancer 10.1 ENO2 KIT
45 achalasia 10.1 ENO2 KIT
46 carcinoid tumors, intestinal 10.0 ENO2 SDHD
47 merkel cell carcinoma 10.0 ENO2 KIT
48 glomus tumor 10.0 ENO2 SDHD
49 adrenal carcinoma 10.0 ENO2 IGF2
50 liver leiomyoma 10.0 ANO1 KIT

Graphical network of the top 20 diseases related to Gastric Leiomyosarcoma:



Diseases related to Gastric Leiomyosarcoma

Symptoms & Phenotypes for Gastric Leiomyosarcoma

MGI Mouse Phenotypes related to Gastric Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 ANO1 ENO2 IGF2 KIT PDGFRA SDHD
2 growth/size/body region MP:0005378 9.7 ANO1 ENO2 IGF2 KIT PDGFRA SDHD
3 embryo MP:0005380 9.65 IGF2 KIT PDGFRA SDHD YARS
4 nervous system MP:0003631 9.43 ANO1 ENO2 IGF2 KIT PDGFRA SDHD
5 respiratory system MP:0005388 9.02 ANO1 ENO2 IGF2 KIT PDGFRA

Drugs & Therapeutics for Gastric Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Gastric Leiomyosarcoma

Genetic Tests for Gastric Leiomyosarcoma

Anatomical Context for Gastric Leiomyosarcoma

MalaCards organs/tissues related to Gastric Leiomyosarcoma:

41
Liver, Lung, Bone, Heart, Spinal Cord, Testis, Small Intestine

Publications for Gastric Leiomyosarcoma

Articles related to Gastric Leiomyosarcoma:

(show top 50) (show all 65)
# Title Authors Year
1
Gastric leiomyosarcoma and diagnostic pitfalls: a case report. ( 30119659 )
2018
2
Gastric leiomyosarcoma revealed by bleeding. ( 30391271 )
2018
3
Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. ( 28426279 )
2017
4
Gastric leiomyosarcoma as a rare cause of gastric outlet obstruction and perforation: a case report. ( 25069607 )
2014
5
Primary gastric leiomyosarcoma in young revealed by a massive hematemesis. ( 19728181 )
2009
6
Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation. ( 19432672 )
2009
7
Hemoperitoneum secondary to spontaneous rupture of metastatic gastric leiomyosarcoma of the liver: report of a case. ( 16830295 )
2006
8
Multifocal soft-tissue metastases of gastric leiomyosarcoma. ( 11880915 )
2002
9
Gastric leiomyosarcoma presenting as severe iron-deficiency anaemia. ( 10468006 )
1999
10
Torricelli-Bernoulli sign in an ulcerating gastric leiomyosarcoma. ( 10397126 )
1999
11
CT of gastric leiomyosarcoma: patterns of involvement. ( 10430139 )
1999
12
Gastrocolic fistula due to adenocarcinoma of the colon: simulation of primary gastric leiomyosarcoma on CT. ( 10665346 )
1999
13
Gastric leiomyosarcoma presenting as a sentinel hemorrhage. ( 10578561 )
1999
14
Gastric leiomyosarcoma mimicking a cystic tumor at the pancreatic tail--one case report. ( 9951946 )
1998
15
Progesterone receptors in gastric leiomyosarcoma. ( 9840313 )
1998
16
Surgical treatment for gastric leiomyosarcoma. ( 9891769 )
1998
17
Intranuclear cytoplasmic inclusions in gastric leiomyosarcoma. ( 9626527 )
1998
18
Gastric leiomyosarcoma presenting as a gastric wall abscess. ( 9820406 )
1998
19
Where does gastric leiomyosarcoma originate? ( 9283880 )
1997
20
Laparoscopic resection of gastric leiomyosarcoma. ( 9449085 )
1997
21
Gastric leiomyosarcoma: detection on plain chest radiograph. ( 9168752 )
1997
22
Surgical management of gastric leiomyosarcoma: evaluation of the propriety of laparoscopic wedge resection. ( 9143578 )
1997
23
Wedge resection of the stomach for gastric leiomyosarcoma. ( 9112920 )
1997
24
Computed tomography of the retropancreatic peritoneal recess: a case of gastric leiomyosarcoma. ( 9311038 )
1997
25
High-dose chemotherapy with autologous peripheral blood stem cell transplantation for metastatic gastric leiomyosarcoma. ( 9384483 )
1997
26
Two cases of low-grade gastric leiomyosarcoma with monosomy 14 as the only change. ( 8830733 )
1996
27
Gastric leiomyosarcoma in a child. ( 8886720 )
1996
28
Gastric leiomyosarcoma associated with hypoglycemia in a dog. ( 8784717 )
1996
29
Gastric leiomyosarcoma (Review). ( 21544445 )
1996
30
Reevaluation of prognostic factors in gastric leiomyosarcoma. ( 7639235 )
1995
31
Gastric leiomyosarcoma: a clinicopathological review. ( 7888469 )
1994
32
Gastric leiomyosarcoma. ( 7961380 )
1994
33
Unique imagings of CT and MR in liver metastasis from gastric leiomyosarcoma. ( 8082867 )
1994
34
Prognostic value of DNA ploidy in primary gastric leiomyosarcoma. ( 8298922 )
1993
35
Gastric leiomyosarcoma in a horse. ( 1601725 )
1992
36
Gastric leiomyosarcoma. ( 1609721 )
1992
37
Immunostaining of gastric leiomyosarcoma for muscle-specific actin. ( 1371904 )
1992
38
A huge gastric leiomyosarcoma diagnosed preoperatively through diagnostic imaging. ( 1771246 )
1991
39
Rare presentation of gastric leiomyosarcoma. ( 1924039 )
1991
40
Gastric leiomyosarcoma. Prognostic factors and surgical management. ( 1863217 )
1991
41
A case of rapidly growing gastric leiomyosarcoma: observations over 18 months. ( 2389729 )
1990
42
Advanced gastric leiomyosarcoma. ( 2729771 )
1989
43
Metastatic potential of gastric leiomyosarcoma. ( 2616371 )
1989
44
Cytogenetic observations in a human gastric leiomyosarcoma. ( 2702621 )
1989
45
Gastric leiomyosarcoma: two unusual cases. ( 2740893 )
1989
46
Gastric leiomyosarcoma. Comparative value of barium examinations, ultrasonography and CT scans. ( 3308463 )
1987
47
Gastric leiomyosarcoma: report of a case. ( 3610696 )
1987
48
Gastric leiomyosarcoma with massive myxoid degeneration. A histochemical and ultrastructural study. ( 3012933 )
1986
49
Carney's triad: gastric leiomyosarcoma, pulmonary chondroma and extra-adrenal paraganglioma in young females. ( 3028925 )
1986
50
Gastric leiomyosarcoma: a clinicopathologic study. ( 3771120 )
1986

Variations for Gastric Leiomyosarcoma

Expression for Gastric Leiomyosarcoma

Search GEO for disease gene expression data for Gastric Leiomyosarcoma.

Pathways for Gastric Leiomyosarcoma

Pathways related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 IGF2 KIT PDGFRA
2 10.97 KIT PDGFRA
3 10.52 IGF2 KIT PDGFRA

GO Terms for Gastric Leiomyosarcoma

Biological processes related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.33 IGF2 KIT PDGFRA
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.32 KIT PDGFRA
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.26 KIT PDGFRA
4 positive regulation of MAPK cascade GO:0043410 9.13 IGF2 KIT PDGFRA
5 positive regulation of phospholipase C activity GO:0010863 8.62 KIT PDGFRA

Molecular functions related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.33 KIT PDGFRA YARS
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 KIT PDGFRA
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 KIT PDGFRA

Sources for Gastric Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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