MCID: GST036
MIFTS: 35

Gastric Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Leiomyosarcoma

MalaCards integrated aliases for Gastric Leiomyosarcoma:

Name: Gastric Leiomyosarcoma 12 15
Leiomyosarcoma of Stomach 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5280
NCIt 51 C27200
UMLS 74 C0744295

Summaries for Gastric Leiomyosarcoma

MalaCards based summary : Gastric Leiomyosarcoma, also known as leiomyosarcoma of stomach, is related to carney triad and leiomyosarcoma. An important gene associated with Gastric Leiomyosarcoma is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are p70S6K Signaling and PI3K-Akt signaling pathway. Affiliated tissues include liver, colon and lung, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Gastric Leiomyosarcoma

Diseases related to Gastric Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 carney triad 32.5 KIT PDGFRA
2 leiomyosarcoma 30.7 ENO2 IGF2 KIT PDGFRA
3 paragangliomas 1 11.3
4 reticular perineurioma 10.3 KIT PDGFRA
5 sm-ahnmd 10.3 KIT PDGFRA
6 desmoid tumor 10.3 KIT PDGFRA
7 hypereosinophilic syndrome, idiopathic 10.3 KIT PDGFRA
8 lung adenoid cystic carcinoma 10.3 KIT PDGFRA
9 pulmonary vein stenosis 10.3 KIT PDGFRA
10 chronic eosinophilic leukemia 10.3 KIT PDGFRA
11 mesenchymal cell neoplasm 10.3 KIT PDGFRA
12 undifferentiated pleomorphic sarcoma 10.3 KIT PDGFRA
13 neurofibroma 10.2 KIT PDGFRA
14 neurofibromatosis, type i 10.2 KIT PDGFRA
15 fibrosarcoma of bone 10.2 KIT PDGFRA
16 embryoma 10.2 IGF2 KIT
17 congenital mesoblastic nephroma 10.2 IGF2 KIT
18 cutaneous ganglioneuroma 10.2 ENO2 KIT
19 plexiform schwannoma 10.2 ENO2 KIT
20 cavernous hemangioma 10.2 KIT PDGFRA
21 rete testis adenocarcinoma 10.2 ENO2 KIT
22 prostate small cell carcinoma 10.2 ENO2 KIT
23 angiomyoma 10.2 ENO2 KIT
24 piebald trait 10.2 KIT PDGFRA
25 meningeal melanocytoma 10.2 ENO2 YARS
26 adenosquamous lung carcinoma 10.2 ENO2 PDGFRA
27 rete testis neoplasm 10.2 ENO2 KIT
28 systemic mastocytosis 10.2 KIT PDGFRA
29 ileum cancer 10.2 ENO2 PDGFRA
30 cerebral neuroblastoma 10.1 ENO2 IGF2
31 mastocytosis 10.1 KIT PDGFRA
32 mixed cell type cancer 10.1 ENO2 KIT
33 large cell neuroendocrine carcinoma 10.1 ENO2 KIT
34 spinal meningioma 10.1 ENO2 IGF2
35 spinal canal and spinal cord meningioma 10.1 ENO2 IGF2
36 dysgerminoma 10.1 ENO2 KIT
37 neurofibromatosis, type iv, of riccardi 10.1 KIT PDGFRA
38 dysgerminoma of ovary 10.1 ENO2 KIT
39 type 1 diabetes mellitus 2 10.1 IGF2 INS
40 hypoglycemic coma 10.1 IGF2 INS
41 insulinomatosis and diabetes mellitus 10.1 IGF2 INS
42 connective tissue cancer 10.1 ENO2 KIT
43 achalasia 10.1 ENO2 KIT
44 paraganglioma 10.1
45 chondroma 10.1
46 nonsyndromic paraganglioma 10.1
47 duodenal somatostatinoma 10.1 ENO2 INS
48 somatostatinoma 10.1 ENO2 INS
49 fetal macrosomia 10.0 IGF2 INS
50 adult syndrome 10.0 IGF2 INS

Graphical network of the top 20 diseases related to Gastric Leiomyosarcoma:



Diseases related to Gastric Leiomyosarcoma

Symptoms & Phenotypes for Gastric Leiomyosarcoma

MGI Mouse Phenotypes related to Gastric Leiomyosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 ANO1 ENO2 IGF2 INS KIT PDGFRA
2 growth/size/body region MP:0005378 9.91 ANO1 ENO2 IGF2 INS KIT PDGFRA
3 digestive/alimentary MP:0005381 9.83 ANO1 IGF2 INS KIT PDGFRA
4 embryo MP:0005380 9.8 IGF2 INS KIT PDGFRA YARS
5 integument MP:0010771 9.72 ANO1 IGF2 INS KIT PDGFRA
6 muscle MP:0005369 9.65 ANO1 IGF2 INS KIT PDGFRA
7 nervous system MP:0003631 9.63 ANO1 ENO2 IGF2 INS KIT PDGFRA
8 renal/urinary system MP:0005367 9.35 ANO1 IGF2 INS KIT PDGFRA
9 respiratory system MP:0005388 9.02 ANO1 ENO2 IGF2 KIT PDGFRA

Drugs & Therapeutics for Gastric Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Gastric Leiomyosarcoma

Genetic Tests for Gastric Leiomyosarcoma

Anatomical Context for Gastric Leiomyosarcoma

MalaCards organs/tissues related to Gastric Leiomyosarcoma:

42
Liver, Colon, Lung, Ovary, Testis, Small Intestine, Bone

Publications for Gastric Leiomyosarcoma

Articles related to Gastric Leiomyosarcoma:

(show top 50) (show all 66)
# Title Authors Year
1
Gastric leiomyosarcoma and diagnostic pitfalls: a case report. ( 30119659 )
2018
2
Gastric leiomyosarcoma revealed by bleeding. ( 30391271 )
2018
3
A case of gastric leiomyosarcoma in a domestic shorthair cat. ( 30559970 )
2018
4
Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. ( 28426279 )
2017
5
Gastric leiomyosarcoma as a rare cause of gastric outlet obstruction and perforation: a case report. ( 25069607 )
2014
6
Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation. ( 19432672 )
2009
7
Primary gastric leiomyosarcoma in young revealed by a massive hematemesis. ( 19728181 )
2009
8
Hemoperitoneum secondary to spontaneous rupture of metastatic gastric leiomyosarcoma of the liver: report of a case. ( 16830295 )
2006
9
Multifocal soft-tissue metastases of gastric leiomyosarcoma. ( 11880915 )
2002
10
Torricelli-Bernoulli sign in an ulcerating gastric leiomyosarcoma. ( 10397126 )
1999
11
CT of gastric leiomyosarcoma: patterns of involvement. ( 10430139 )
1999
12
Gastric leiomyosarcoma presenting as severe iron-deficiency anaemia. ( 10468006 )
1999
13
Gastric leiomyosarcoma presenting as a sentinel hemorrhage. ( 10578561 )
1999
14
Gastrocolic fistula due to adenocarcinoma of the colon: simulation of primary gastric leiomyosarcoma on CT. ( 10665346 )
1999
15
Intranuclear cytoplasmic inclusions in gastric leiomyosarcoma. ( 9626527 )
1998
16
Gastric leiomyosarcoma presenting as a gastric wall abscess. ( 9820406 )
1998
17
Progesterone receptors in gastric leiomyosarcoma. ( 9840313 )
1998
18
Surgical treatment for gastric leiomyosarcoma. ( 9891769 )
1998
19
Gastric leiomyosarcoma mimicking a cystic tumor at the pancreatic tail--one case report. ( 9951946 )
1998
20
Wedge resection of the stomach for gastric leiomyosarcoma. ( 9112920 )
1997
21
Surgical management of gastric leiomyosarcoma: evaluation of the propriety of laparoscopic wedge resection. ( 9143578 )
1997
22
Gastric leiomyosarcoma: detection on plain chest radiograph. ( 9168752 )
1997
23
Where does gastric leiomyosarcoma originate? ( 9283880 )
1997
24
Computed tomography of the retropancreatic peritoneal recess: a case of gastric leiomyosarcoma. ( 9311038 )
1997
25
High-dose chemotherapy with autologous peripheral blood stem cell transplantation for metastatic gastric leiomyosarcoma. ( 9384483 )
1997
26
Laparoscopic resection of gastric leiomyosarcoma. ( 9449085 )
1997
27
Gastric leiomyosarcoma associated with hypoglycemia in a dog. ( 8784717 )
1996
28
Two cases of low-grade gastric leiomyosarcoma with monosomy 14 as the only change. ( 8830733 )
1996
29
Gastric leiomyosarcoma in a child. ( 8886720 )
1996
30
Gastric leiomyosarcoma (Review). ( 21544445 )
1996
31
Reevaluation of prognostic factors in gastric leiomyosarcoma. ( 7639235 )
1995
32
Gastric leiomyosarcoma: a clinicopathological review. ( 7888469 )
1994
33
Gastric leiomyosarcoma. ( 7961380 )
1994
34
Unique imagings of CT and MR in liver metastasis from gastric leiomyosarcoma. ( 8082867 )
1994
35
Prognostic value of DNA ploidy in primary gastric leiomyosarcoma. ( 8298922 )
1993
36
Immunostaining of gastric leiomyosarcoma for muscle-specific actin. ( 1371904 )
1992
37
Gastric leiomyosarcoma in a horse. ( 1601725 )
1992
38
Gastric leiomyosarcoma. ( 1609721 )
1992
39
A huge gastric leiomyosarcoma diagnosed preoperatively through diagnostic imaging. ( 1771246 )
1991
40
Gastric leiomyosarcoma. Prognostic factors and surgical management. ( 1863217 )
1991
41
Rare presentation of gastric leiomyosarcoma. ( 1924039 )
1991
42
A case of rapidly growing gastric leiomyosarcoma: observations over 18 months. ( 2389729 )
1990
43
Metastatic potential of gastric leiomyosarcoma. ( 2616371 )
1989
44
Cytogenetic observations in a human gastric leiomyosarcoma. ( 2702621 )
1989
45
Advanced gastric leiomyosarcoma. ( 2729771 )
1989
46
Gastric leiomyosarcoma: two unusual cases. ( 2740893 )
1989
47
Gastric leiomyosarcoma. Comparative value of barium examinations, ultrasonography and CT scans. ( 3308463 )
1987
48
Gastric leiomyosarcoma: report of a case. ( 3610696 )
1987
49
Carney's triad: gastric leiomyosarcoma, pulmonary chondroma and extra-adrenal paraganglioma in young females. ( 3028925 )
1986
50
Gastric leiomyosarcoma with massive myxoid degeneration. A histochemical and ultrastructural study. ( 3012933 )
1986

Variations for Gastric Leiomyosarcoma

Expression for Gastric Leiomyosarcoma

Search GEO for disease gene expression data for Gastric Leiomyosarcoma.

Pathways for Gastric Leiomyosarcoma

GO Terms for Gastric Leiomyosarcoma

Cellular components related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ENO2 IGF2 INS KIT YARS

Biological processes related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 IGF2 INS KIT PDGFRA
2 positive regulation of cell migration GO:0030335 9.63 INS KIT PDGFRA
3 glucose metabolic process GO:0006006 9.49 IGF2 INS
4 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.48 KIT PDGFRA
5 positive regulation of mitotic nuclear division GO:0045840 9.43 IGF2 INS
6 positive regulation of glycogen biosynthetic process GO:0045725 9.37 IGF2 INS
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.33 INS KIT PDGFRA
8 positive regulation of insulin receptor signaling pathway GO:0046628 9.32 IGF2 INS
9 positive regulation of phospholipase C activity GO:0010863 9.26 KIT PDGFRA
10 positive regulation of protein kinase B signaling GO:0051897 9.26 IGF2 INS KIT PDGFRA
11 positive regulation of MAPK cascade GO:0043410 8.92 IGF2 INS KIT PDGFRA

Molecular functions related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 KIT PDGFRA
2 insulin receptor binding GO:0005158 8.96 IGF2 INS
3 insulin-like growth factor receptor binding GO:0005159 8.62 IGF2 INS

Sources for Gastric Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....