MCID: GST036
MIFTS: 30

Gastric Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Leiomyosarcoma

MalaCards integrated aliases for Gastric Leiomyosarcoma:

Name: Gastric Leiomyosarcoma 12 15
Leiomyosarcoma of Stomach 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5280
NCIt 50 C27200
SNOMED-CT 68 447785000
UMLS 73 C0744295

Summaries for Gastric Leiomyosarcoma

MalaCards based summary : Gastric Leiomyosarcoma, also known as leiomyosarcoma of stomach, is related to carney triad and leiomyosarcoma. An important gene associated with Gastric Leiomyosarcoma is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are B Cell Development Pathways and Cardiac Progenitor Differentiation. Affiliated tissues include liver and colon, and related phenotypes are growth/size/body region and respiratory system

Related Diseases for Gastric Leiomyosarcoma

Diseases related to Gastric Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 carney triad 31.9 KIT PDGFRA SDHD
2 leiomyosarcoma 30.4 ENO2 IGF2 KIT PDGFRA
3 paragangliomas 1 11.1
4 reticular perineurioma 10.7 KIT PDGFRA
5 sm-ahnmd 10.7 KIT PDGFRA
6 desmoid tumor 10.6 KIT PDGFRA
7 sarcomatoid renal cell carcinoma 10.6 KIT PDGFRA
8 pulmonary vein stenosis 10.6 KIT PDGFRA
9 hypereosinophilic syndrome, idiopathic 10.6 KIT PDGFRA
10 undifferentiated pleomorphic sarcoma 10.6 KIT PDGFRA
11 lung adenoid cystic carcinoma 10.6 KIT PDGFRA
12 chronic eosinophilic leukemia 10.6 KIT PDGFRA
13 neurofibromatosis, type i 10.5 KIT PDGFRA
14 cutaneous ganglioneuroma 10.5 ENO2 KIT
15 rete testis adenocarcinoma 10.5 ENO2 KIT
16 congenital mesoblastic nephroma 10.5 IGF2 KIT
17 gallbladder leiomyoma 10.5 CD34 KIT
18 lung leiomyosarcoma 10.5 CD34 KIT
19 adenosquamous cell lung carcinoma 10.4 ENO2 PDGFRA
20 cerebral neuroblastoma 10.4 ENO2 IGF2
21 fibrosarcoma of bone 10.4 KIT PDGFRA
22 deep leiomyoma 10.4 CD34 KIT
23 meningeal melanocytoma 10.4 ENO2 YARS
24 extracutaneous mastocytoma 10.4 CD34 KIT
25 rete testis neoplasm 10.4 ENO2 KIT
26 gallbladder sarcoma 10.4 CD34 KIT
27 prostate leiomyosarcoma 10.4 CD34 KIT
28 mixed cell type cancer 10.4 ENO2 KIT
29 diffuse cutaneous mastocytosis 10.4 CD34 KIT
30 sarcomatoid squamous cell skin carcinoma 10.4 CD34 KIT
31 breast angiosarcoma 10.4 CD34 KIT
32 meninges sarcoma 10.4 CD34 IGF2
33 senile angioma 10.4 CD34 KIT
34 spindle cell liposarcoma 10.4 CD34 KIT
35 piebald trait 10.4 KIT PDGFRA
36 spinal meningioma 10.3 ENO2 IGF2
37 dysgerminoma of ovary 10.3 ENO2 KIT
38 spinal canal and spinal cord meningioma 10.3 ENO2 IGF2
39 large cell neuroendocrine carcinoma 10.3 ENO2 KIT
40 periosteal osteogenic sarcoma 10.3 CD34 IGF2
41 lung meningioma 10.3 CD34 ENO2
42 systemic mastocytosis 10.3 KIT PDGFRA
43 carcinoid tumors, intestinal 10.3 ENO2 SDHD
44 neurofibroma 10.2 KIT PDGFRA
45 spindle cell synovial sarcoma 10.2 CD34 KIT
46 rubeosis iridis 10.2 ENO2 IGF2
47 glomus tumor 10.2 ENO2 SDHD
48 mast cell disease 10.2 KIT PDGFRA
49 congenital epulis 10.2 CD34 ENO2
50 liver angiosarcoma 10.2 CD34 ENO2

Graphical network of the top 20 diseases related to Gastric Leiomyosarcoma:



Diseases related to Gastric Leiomyosarcoma

Symptoms & Phenotypes for Gastric Leiomyosarcoma

MGI Mouse Phenotypes related to Gastric Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.5 YARS ANO1 ENO2 IGF2 KIT PDGFRA
2 respiratory system MP:0005388 9.02 ANO1 ENO2 IGF2 KIT PDGFRA

Drugs & Therapeutics for Gastric Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Gastric Leiomyosarcoma

Genetic Tests for Gastric Leiomyosarcoma

Anatomical Context for Gastric Leiomyosarcoma

MalaCards organs/tissues related to Gastric Leiomyosarcoma:

41
Liver, Colon

Publications for Gastric Leiomyosarcoma

Articles related to Gastric Leiomyosarcoma:

(show top 50) (show all 63)
# Title Authors Year
1
Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. ( 28426279 )
2017
2
Gastric leiomyosarcoma as a rare cause of gastric outlet obstruction and perforation: a case report. ( 25069607 )
2014
3
Primary gastric leiomyosarcoma in young revealed by a massive hematemesis. ( 19728181 )
2009
4
Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation. ( 19432672 )
2009
5
Hemoperitoneum secondary to spontaneous rupture of metastatic gastric leiomyosarcoma of the liver: report of a case. ( 16830295 )
2006
6
Multifocal soft-tissue metastases of gastric leiomyosarcoma. ( 11880915 )
2002
7
Gastric leiomyosarcoma presenting as severe iron-deficiency anaemia. ( 10468006 )
1999
8
Torricelli-Bernoulli sign in an ulcerating gastric leiomyosarcoma. ( 10397126 )
1999
9
CT of gastric leiomyosarcoma: patterns of involvement. ( 10430139 )
1999
10
Gastrocolic fistula due to adenocarcinoma of the colon: simulation of primary gastric leiomyosarcoma on CT. ( 10665346 )
1999
11
Gastric leiomyosarcoma presenting as a sentinel hemorrhage. ( 10578561 )
1999
12
Gastric leiomyosarcoma mimicking a cystic tumor at the pancreatic tail--one case report. ( 9951946 )
1998
13
Progesterone receptors in gastric leiomyosarcoma. ( 9840313 )
1998
14
Surgical treatment for gastric leiomyosarcoma. ( 9891769 )
1998
15
Intranuclear cytoplasmic inclusions in gastric leiomyosarcoma. ( 9626527 )
1998
16
Gastric leiomyosarcoma presenting as a gastric wall abscess. ( 9820406 )
1998
17
Where does gastric leiomyosarcoma originate? ( 9283880 )
1997
18
Laparoscopic resection of gastric leiomyosarcoma. ( 9449085 )
1997
19
Gastric leiomyosarcoma: detection on plain chest radiograph. ( 9168752 )
1997
20
Surgical management of gastric leiomyosarcoma: evaluation of the propriety of laparoscopic wedge resection. ( 9143578 )
1997
21
Wedge resection of the stomach for gastric leiomyosarcoma. ( 9112920 )
1997
22
Computed tomography of the retropancreatic peritoneal recess: a case of gastric leiomyosarcoma. ( 9311038 )
1997
23
High-dose chemotherapy with autologous peripheral blood stem cell transplantation for metastatic gastric leiomyosarcoma. ( 9384483 )
1997
24
Two cases of low-grade gastric leiomyosarcoma with monosomy 14 as the only change. ( 8830733 )
1996
25
Gastric leiomyosarcoma in a child. ( 8886720 )
1996
26
Gastric leiomyosarcoma associated with hypoglycemia in a dog. ( 8784717 )
1996
27
Gastric leiomyosarcoma (Review). ( 21544445 )
1996
28
Reevaluation of prognostic factors in gastric leiomyosarcoma. ( 7639235 )
1995
29
Gastric leiomyosarcoma: a clinicopathological review. ( 7888469 )
1994
30
Gastric leiomyosarcoma. ( 7961380 )
1994
31
Unique imagings of CT and MR in liver metastasis from gastric leiomyosarcoma. ( 8082867 )
1994
32
Prognostic value of DNA ploidy in primary gastric leiomyosarcoma. ( 8298922 )
1993
33
Gastric leiomyosarcoma in a horse. ( 1601725 )
1992
34
Gastric leiomyosarcoma. ( 1609721 )
1992
35
Immunostaining of gastric leiomyosarcoma for muscle-specific actin. ( 1371904 )
1992
36
A huge gastric leiomyosarcoma diagnosed preoperatively through diagnostic imaging. ( 1771246 )
1991
37
Rare presentation of gastric leiomyosarcoma. ( 1924039 )
1991
38
Gastric leiomyosarcoma. Prognostic factors and surgical management. ( 1863217 )
1991
39
A case of rapidly growing gastric leiomyosarcoma: observations over 18 months. ( 2389729 )
1990
40
Advanced gastric leiomyosarcoma. ( 2729771 )
1989
41
Metastatic potential of gastric leiomyosarcoma. ( 2616371 )
1989
42
Cytogenetic observations in a human gastric leiomyosarcoma. ( 2702621 )
1989
43
Gastric leiomyosarcoma: two unusual cases. ( 2740893 )
1989
44
Gastric leiomyosarcoma. Comparative value of barium examinations, ultrasonography and CT scans. ( 3308463 )
1987
45
Gastric leiomyosarcoma: report of a case. ( 3610696 )
1987
46
Gastric leiomyosarcoma with massive myxoid degeneration. A histochemical and ultrastructural study. ( 3012933 )
1986
47
Carney's triad: gastric leiomyosarcoma, pulmonary chondroma and extra-adrenal paraganglioma in young females. ( 3028925 )
1986
48
Gastric leiomyosarcoma: a clinicopathologic study. ( 3771120 )
1986
49
Gastric leiomyosarcoma: CT observations. ( 3973157 )
1985
50
Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. ( 6692300 )
1984

Variations for Gastric Leiomyosarcoma

Expression for Gastric Leiomyosarcoma

Search GEO for disease gene expression data for Gastric Leiomyosarcoma.

Pathways for Gastric Leiomyosarcoma

Pathways related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.68 CD34 KIT
2 10.52 IGF2 KIT PDGFRA

GO Terms for Gastric Leiomyosarcoma

Cellular components related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD34 KIT PDGFRA

Biological processes related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.43 IGF2 KIT PDGFRA
2 positive regulation of MAPK cascade GO:0043410 9.33 IGF2 KIT PDGFRA
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.32 KIT PDGFRA
4 positive regulation of phospholipase C activity GO:0010863 8.96 KIT PDGFRA
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 IGF2 KIT PDGFRA

Molecular functions related to Gastric Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 KIT PDGFRA
2 growth factor binding GO:0019838 8.62 KIT PDGFRA

Sources for Gastric Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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