MCID: GST027
MIFTS: 54

Gastric Lymphoma

Categories: Cancer diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Gastric Lymphoma

MalaCards integrated aliases for Gastric Lymphoma:

Name: Gastric Lymphoma 12 76 53 29 55 15 73
Familial Primary Gastric Lymphoma 53 44 73
Lymphoma, Gastric, Primary 40
Primary Gastric Lymphoma 53
Lymphoma of the Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10540
MeSH 44 C535648
NCIt 50 C4636

Summaries for Gastric Lymphoma

MalaCards based summary : Gastric Lymphoma, also known as familial primary gastric lymphoma, is related to lymphoma, mucosa-associated lymphoid type and lymphoma. An important gene associated with Gastric Lymphoma is BCL10 (BCL10, Immune Signaling Adaptor), and among its related pathways/superpathways are Regulation of TP53 Activity and Human cytomegalovirus infection. The drugs Clarithromycin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Primary gastric lymphoma (lymphoma that originates in the stomach itself) is an uncommon condition,... more...

Related Diseases for Gastric Lymphoma

Diseases related to Gastric Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 lymphoma, mucosa-associated lymphoid type 32.1 BCL6 BCL2 BCL10 ATP4A ATP12A
2 lymphoma 31.2 BAX BCL10 BCL2 BCL6
3 follicular lymphoma 30.0 BCL6 BCL2 BCL10
4 marginal zone b-cell lymphoma 30.0 BCL6 BCL2 BCL10
5 burkitt lymphoma 29.9 BCL6 BCL2 BAX
6 gastric adenocarcinoma 29.8 VEGFA TP53 BCL2 BAX
7 lymphoma, non-hodgkin, familial 29.6 TP53 BCL6 BCL2 BCL10 BAX
8 acquired immunodeficiency syndrome 29.6 ALB BCL6 TP53
9 granulomatous gastritis 29.4 ATP4A ATP12A
10 b-cell lymphomas 29.4 TP53 BCL6 BCL2 BCL10 BAX
11 microinvasive gastric cancer 29.3 ATP4A ATP12A
12 lymphoma, gastric non hodgkins type 11.1
13 nodal marginal zone lymphoma 10.3
14 helicobacter pylori infection 10.2
15 adenocarcinoma 10.2
16 mature teratoma 10.2 TP53 PCNA
17 oral leukoplakia 10.2 TP53 PCNA
18 fibrillary astrocytoma 10.2 TP53 PCNA
19 central nervous system hematologic cancer 10.2 TP53 BCL6
20 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.2 BCL6 BCL2
21 nodal marginal zone b-cell lymphoma 10.2 BCL2 BCL6
22 intravascular large b-cell lymphoma 10.2 BCL6 BCL2
23 primary mediastinal large b-cell lymphoma 10.2 BCL6 BCL2
24 primary effusion lymphoma 10.2 VEGFA BCL6
25 lipodermatosclerosis 10.2 VEGFA PCNA
26 severe nonproliferative diabetic retinopathy 10.2 VEGFA ALB
27 primary central nervous system lymphoma 10.2 BCL6 BCL2
28 human herpesvirus 8 10.1 BCL6 BCL2
29 acroosteolysis 10.1 VEGFA ALB
30 gastritis 10.1
31 autoimmune lymphoproliferative syndrome, type v 10.1 BCL6 BCL2
32 ulcerative stomatitis 10.1 TP53 ALB
33 background diabetic retinopathy 10.1 VEGFA ALB
34 cervical carcinosarcoma 10.1 TP53 BCL2
35 plasmablastic lymphoma 10.1
36 rh isoimmunization 10.1 BCL10 ALB
37 hypertensive nephropathy 10.1 VEGFA ALB
38 acinar cell carcinoma 10.1 TP53 BCL10
39 lymphoma, hodgkin, classic 10.1
40 primary peritoneal carcinoma 10.1 VEGFA TP53
41 hidradenocarcinoma 10.1 TP53 BCL2
42 gastric cancer 10.1
43 follicular lymphoma 1 10.1 BCL6 BCL2 BCL10
44 grade iii astrocytoma 10.1 VEGFA TP53 PCNA
45 meningioma, familial 10.1 VEGFA TP53 PCNA
46 testicular torsion 10.0 TP53 PCNA BCL2
47 mantle cell lymphoma 10.0 TP53 BCL6 BCL2
48 hydrops, lactic acidosis, and sideroblastic anemia 10.0 VEGFA ALB
49 gastrointestinal system cancer 10.0 VEGFA TP53 ALB
50 respiratory system disease 10.0 VEGFA TP53 ALB

Graphical network of the top 20 diseases related to Gastric Lymphoma:



Diseases related to Gastric Lymphoma

Symptoms & Phenotypes for Gastric Lymphoma

GenomeRNAi Phenotypes related to Gastric Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 BAX BCL10 BCL2 PCNA TP53
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 BAX BCL10 BCL2 PCNA TP53

MGI Mouse Phenotypes related to Gastric Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.11 ALB ATP4A BAX BCL10 BCL2 BCL6
2 hematopoietic system MP:0005397 10.03 ATP4A BAX BCL10 BCL2 BCL6 PCNA
3 homeostasis/metabolism MP:0005376 10.01 ALB ATP12A ATP4A BAX BCL2 BCL6
4 immune system MP:0005387 9.97 ATP4A BAX BCL10 BCL2 BCL6 PCNA
5 mortality/aging MP:0010768 9.97 ALB ATP4A BAX BCL10 BCL2 BCL6
6 digestive/alimentary MP:0005381 9.95 ALB ATP12A ATP4A BCL2 TP53 VEGFA
7 muscle MP:0005369 9.73 ALB BAX BCL2 BCL6 TP53 VEGFA
8 neoplasm MP:0002006 9.63 ALB ATP4A BAX BCL2 TP53 VEGFA
9 renal/urinary system MP:0005367 9.43 ALB ATP12A BAX BCL2 TP53 VEGFA
10 reproductive system MP:0005389 9.1 BAX BCL2 BCL6 PCNA TP53 VEGFA

Drugs & Therapeutics for Gastric Lymphoma

Drugs for Gastric Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4,Phase 3,Phase 2 81103-11-9 84029
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
3
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
4
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
5
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
6
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
7 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
8 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2
10 Proton Pump Inhibitors Phase 4,Phase 3,Phase 2
11 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2
12 Antacids Phase 4,Phase 3,Phase 2
13 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
14 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
15 Antiparasitic Agents Phase 4,Phase 3,Phase 2
16 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 4,Phase 2
18
Chlorambucil Approved Phase 3,Phase 2 305-03-3 2708
19
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
20
Omeprazole Approved, Investigational, Vet_approved Phase 3,Phase 2 73590-58-6 4594
21 Antineoplastic Agents, Alkylating Phase 3,Phase 2
22 Alkylating Agents Phase 3,Phase 2
23
Tetracycline Approved, Vet_approved Phase 2 60-54-8 5353990
24
Loperamide Approved Phase 2 53179-11-6 3955
25
Bismuth Subsalicylate Approved, Vet_approved Phase 2 14882-18-9 53629521
26
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
27
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
28
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
29
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
30
rituximab Approved Phase 2 174722-31-7 10201696
31
Lenalidomide Approved Phase 2 191732-72-6 216326
32
Doxil Approved June 1999 Phase 2 31703
33
Bismuth Phase 2 7440-69-9 16682734 105143
34 Bismuth tripotassium dicitrate Phase 2
35 Antidiarrheals Phase 2
36 Antitubercular Agents Phase 2
37 Antirheumatic Agents Phase 2
38 Immunologic Factors Phase 2
39 Angiogenesis Inhibitors Phase 2
40 Immunosuppressive Agents Phase 2
41 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Intraluminal Therapy for Helicobacter Pylori Infection Completed NCT03124420 Phase 4 Lansoprazole;Amoxicillin;Clarithromycin
2 Intraluminal Amoxicillin Powder Monotherapy for Helicobacter Pylori Infection Recruiting NCT03521726 Phase 4 Amoxicillin;Rabeprazole, Amoxicillin
3 Intraluminal Clarithromycin Powder Monotherapy for Helicobacter Pylori Infection Recruiting NCT03516669 Phase 4 Clarithromycin;Amoxicillin, Clarithromycin
4 Intraluminal Metronidazole Powder Monotherapy for Helicobacter Pylori Infection Not yet recruiting NCT03524833 Phase 4 Metronidazole;Lansoprazole, Amoxicillin, Metronidazole
5 Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the Stomach Unknown status NCT00003617 Phase 3 chlorambucil;clarithromycin;omeprazole;tinidazole
6 Helicobacter – Lymphoma – Radiation Part I: Eradication, Part II: Radiation Unknown status NCT00154440 Phase 3 proton pump inhibitor;clarithromycin;amoxicillin;metronidazole
7 Antibiotic Therapy in Treating Patients With Low Grade Gastric Lymphoma Completed NCT00003151 Phase 2 amoxicillin;clarithromycin;metronidazole hydrochloride;omeprazole;tetracycline hydrochloride
8 Antibiotic Therapy and Antacids in Patients With Malt Lymphoma of the Stomach Completed NCT00002682 Phase 2 Amoxicillin;Bismuth Subsalicylate;Clarithromycin;Metronidazole Hydrochloride;Omeprazole;Tetracycline Hydrochloride
9 Phase II Study With Rituximab and Cyclophosphamide, Doxorubicin, Vincristine, Prednisone (CHOP) in Patients With Gastric Diffuse Large B-Cell Non-Hodgkin`s Lymphoma Completed NCT00204659 Phase 2 Rituximab + CHOP chemotherapy
10 Clarithromycin + Lenalidomide Combination: a Full Oral Treatment for Patients With Relapsed/Refractory Extranodal Marginal Zone Lymphoma Recruiting NCT03031483 Phase 2 clarithromycin and lenalidomide
11 Phase II Study of Chlorambucil and Subcutaneous Rituximab in Patients With Extranodal MALT Lymphoma Active, not recruiting NCT01808599 Phase 2 Chlorambucil;Rituximab i.v.;Rituximab s.c.
12 Immediate Detection of Helicobacter Infection With a New Electrochemical System. Unknown status NCT01234389 Not Applicable
13 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831

Search NIH Clinical Center for Gastric Lymphoma

Cochrane evidence based reviews: familial primary gastric lymphoma

Genetic Tests for Gastric Lymphoma

Genetic tests related to Gastric Lymphoma:

# Genetic test Affiliating Genes
1 Gastric Lymphoma 29 BCL10

Anatomical Context for Gastric Lymphoma

MalaCards organs/tissues related to Gastric Lymphoma:

41
B Cells, T Cells, Lung, Liver, Skin, Bone, Thyroid

Publications for Gastric Lymphoma

Articles related to Gastric Lymphoma:

(show top 50) (show all 439)
# Title Authors Year
1
Gastric inflammatory fibroid polyp tumor with acute intestinal obstruction-Vanek's tumor can mimick a giant gastrointestinal stromal tumor or a gastric lymphoma. ( 29682464 )
2018
2
Four-dimensional cone-beam computed tomography-guided radiotherapy for gastric lymphoma. ( 29086348 )
2018
3
Primary Gastric Lymphoma: Clinicopathological Profile. ( 29963454 )
2018
4
Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment. ( 29779412 )
2018
5
Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study. ( 30008745 )
2018
6
Severe upper gastrointestinal bleeding determined by a gastric lymphoma associated with Helicobacter pylori-positive atrophic gastritis. ( 28730251 )
2017
7
Gastric Kaposi's sarcoma simulating gastric lymphoma during endoscopic ultrasound examination. ( 28685740 )
2017
8
Isolated Pulmonary Valve Vegetations in a Patient with Gastric Lymphoma Diagnosed by Endoscopic Ultrasound. ( 29560679 )
2017
9
Gastric lymphoma: association with Helicobacter pylori outer membrane protein Q (HopQ) and cytotoxic-pathogenicity activity island (CPAI) genes. ( 29143724 )
2017
10
The Role of Endoscopic Ultrasound in the Diagnosis and Management of Primary Gastric Lymphoma. ( 28400819 )
2017
11
CT-based radiomics signature for differentiating Borrmann type IV gastric cancer from primary gastric lymphoma. ( 28629560 )
2017
12
Multimodality Treatment of Gastric Lymphoma. ( 28325194 )
2017
13
Clinical manifestations and endoscopic presentations of gastric lymphoma: a multicenter seven year retrospective survey. ( 28617031 )
2017
14
Diffuse large B cell gastric lymphoma a rare disease: the effort to obtain scientific data in a multicenter, multinational retrospective trial. ( 27521853 )
2016
15
Prognostic value of SUVmax measured by pretreatment 18F-FDG PET/CT in patients with primary gastric lymphoma. ( 27482643 )
2016
16
The clinical characteristics of primary gastric lymphoma detected during screening for gastric cancer in Korea. ( 26850225 )
2016
17
18F-FDG PET/CT Imaging of Primary Gastric Lymphoma. ( 27493260 )
2016
18
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography comparison of gastric lymphoma and gastric carcinoma. ( 27678362 )
2016
19
4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma : Determination of intra- and interfractional gastric motion. ( 26902523 )
2016
20
H. pylori-associated gastric lymphoma: Complete remission in an HIV-positive patient treated with HAART and H. pylori eradication therapy. ( 27206927 )
2016
21
Clinical characteristics and prognostic factors of primary gastric lymphoma: A retrospective study with 165 cases. ( 27495029 )
2016
22
Indication for liver transplantation in a patient with a history of a gastric lymphoma. ( 26937630 )
2016
23
High expression of PTPN21 in B-cell non-Hodgkin's gastric lymphoma, a positive mediator of STAT5 activity. ( 26771814 )
2016
24
Massive gastrointestinal bleeding after chemotherapy for gastric lymphoma. ( 26921535 )
2016
25
Survival of patients with gastric lymphoma in Germany and in the United States. ( 25967274 )
2015
26
Colonic inflammation in a samoan immigrant with gastric lymphoma shown by positron emission tomography. ( 25948555 )
2015
27
Primary gastric lymphoma in a soldier presenting as acute gastrointestinal bleeding. ( 28265419 )
2015
28
Refractory peptic ulceration following radiation therapy in primary gastric lymphoma: A report of two cases. ( 25435934 )
2015
29
Spontaneous regression of high grade primary gastric Lymphoma in an untreated viral hepatitis infection. ( 24512317 )
2014
30
Gastrocolic fistula secondary to primary gastric lymphoma. ( 24932326 )
2014
31
A retrospective study of feline gastric lymphoma in 16 chemotherapy-treated cats. ( 24216491 )
2014
32
Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy. ( 25161174 )
2014
33
Treatment modalities in primary gastric lymphoma: the effect of rituximab and surgical treatment. A study by the Anatolian Society of Medical Oncology. ( 25258586 )
2014
34
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography findings of gastric lymphoma: Comparisons with gastric cancer. ( 25202405 )
2014
35
Clinicopathological characteristics and therapeutic outcomes of synchronous gastric adenocarcinoma and gastric lymphoma. ( 25202092 )
2014
36
The evolving role of surgery for gastric lymphoma: from curative resection to surgical management of complications. ( 25347493 )
2014
37
Malignant gastric lymphoma with spontaneous perforation. ( 23329705 )
2013
38
Hepatic dysfunction after radiotherapy for primary gastric lymphoma. ( 23283868 )
2013
39
Primary Gastric Lymphoma Presenting as Acute Pancreatitis: A Case Report. ( 23846949 )
2013
40
Clonal immunoglobulin heavy chain and T-cell receptor I^ gene rearrangements in primary gastric lymphoma. ( 24039368 )
2013
41
Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma. ( 23425357 )
2013
42
Primary gastric lymphoma: utility of 18F-fluorodeoxyglucose positron emission tomography-computed tomography for detecting relapse after treatment. ( 23043310 )
2013
43
Predictive value of endoscopic ultrasound in diagnosis and staging of primary gastric lymphoma. ( 23837259 )
2013
44
Unconvincing diagnosis of a rare subtype of primary gastric lymphoma with incongruent endoscopic presentation: a case of gastric schwannoma. ( 24365735 )
2013
45
Review of the molecular profile and modern prognostic markers for gastric lymphoma: how do they affect clinical practice? ( 22564515 )
2012
46
Primary gastric lymphoma: conservative treatment modality is not inferior to surgery for early-stage disease. ( 22988526 )
2012
47
Correlational study of vascular endothelial growth factor expression and microvessel density in primary malignant gastric lymphoma. ( 21710234 )
2012
48
A case of eosinophilic gastroenteritis mimicking gastric lymphoma associated with pancreatitis due to duodenal involvement. ( 23161306 )
2012
49
The diagnostic characteristics of a group of patients with primary gastric lymphoma: macroscopic, histopathological and immunohistochemical aspects. ( 22732804 )
2012
50
The remarkably distensible stomach: Case report highlighting the implications of gastric filling on radiation treatment planning for gastric lymphoma. ( 24674162 )
2012

Variations for Gastric Lymphoma

Expression for Gastric Lymphoma

Search GEO for disease gene expression data for Gastric Lymphoma.

Pathways for Gastric Lymphoma

Pathways related to Gastric Lymphoma according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 BAX BCL6 PCNA TP53
2
Show member pathways
12.78 BAX BCL2 PCNA TP53 VEGFA
3 12.65 BAX BCL2 TP53 VEGFA
4
Show member pathways
12.6 BAX BCL2 PCNA TP53 VEGFA
5
Show member pathways
12.58 BAX BCL2 TP53 VEGFA
6
Show member pathways
12.51 BAX BCL2 PCNA TP53
7
Show member pathways
12.24 BAX BCL2 TP53
8 12.16 BAX BCL2 TP53
9 12.11 BAX BCL6 TP53
10 12.1 BAX BCL10 BCL2
11
Show member pathways
12.1 BAX BCL2 TP53
12 12.08 BAX BCL10 BCL2
13 12.02 BAX TP53 VEGFA
14 11.99 BAX BCL2 TP53
15 11.92 BCL2 TP53 VEGFA
16 11.9 BCL2 TP53 VEGFA
17
Show member pathways
11.86 BAX BCL2 TP53
18 11.83 BAX BCL2 TP53
19
Show member pathways
11.81 BAX BCL2 TP53
20 11.81 BAX BCL2 TP53 VEGFA
21 11.77 BCL2 PCNA TP53
22
Show member pathways
11.76 BAX BCL6 TP53
23
Show member pathways
11.73 BAX PCNA TP53
24 11.7 BAX BCL2 VEGFA
25 11.65 BAX BCL2 TP53
26 11.62 BAX BCL2 BCL6 TP53
27 11.55 BCL2 TP53 VEGFA
28 11.52 BAX BCL2 TP53
29 11.51 BCL2 BCL6 TP53 VEGFA
30 11.44 BCL10 PCNA TP53
31 11.32 BAX BCL2 TP53
32 11.24 BAX BCL2 TP53
33 11.19 BAX BCL2
34 11.19 PCNA TP53
35 11.14 PCNA TP53
36 11.14 BAX BCL2 BCL6 PCNA TP53
37 11.12 BAX BCL2
38 11.11 BAX TP53 VEGFA
39 11.01 BAX BCL2
41 10.9 BAX BCL2
42 10.54 BAX BCL2
43
Show member pathways
10.47 BAX BCL2 TP53

GO Terms for Gastric Lymphoma

Cellular components related to Gastric Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.46 ALB BCL10 BCL2 TP53
2 replication fork GO:0005657 8.96 BCL6 PCNA
3 pore complex GO:0046930 8.62 BAX BCL2

Biological processes related to Gastric Lymphoma according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.93 BAX BCL2 BCL6 TP53
2 cell proliferation GO:0008283 9.89 BAX BCL2 PCNA TP53
3 negative regulation of apoptotic process GO:0043066 9.89 ALB BCL2 BCL6 TP53 VEGFA
4 positive regulation of apoptotic process GO:0043065 9.88 BAX BCL10 BCL6 TP53
5 cytokine-mediated signaling pathway GO:0019221 9.83 BCL2 BCL6 TP53 VEGFA
6 cellular response to DNA damage stimulus GO:0006974 9.83 BAX BCL2 BCL6 PCNA TP53
7 cellular response to hypoxia GO:0071456 9.8 BCL2 TP53 VEGFA
8 negative regulation of cell growth GO:0030308 9.79 BCL2 BCL6 TP53
9 kidney development GO:0001822 9.77 BAX BCL2 VEGFA
10 neuron apoptotic process GO:0051402 9.7 BAX BCL2
11 potassium ion import GO:0010107 9.7 ATP12A ATP4A
12 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.7 BAX BCL2
13 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.69 BAX BCL2
14 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.69 BAX BCL2
15 negative regulation of fibroblast proliferation GO:0048147 9.69 BAX TP53
16 homeostasis of number of cells within a tissue GO:0048873 9.68 BAX BCL2
17 intrinsic apoptotic signaling pathway GO:0097193 9.68 BAX TP53
18 ATP hydrolysis coupled proton transport GO:0015991 9.68 ATP12A ATP4A
19 cell aging GO:0007569 9.68 BCL2 TP53
20 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.67 BAX TP53
21 regulation of mitochondrial membrane potential GO:0051881 9.67 BAX BCL2
22 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.67 BAX TP53
23 negative regulation of apoptotic signaling pathway GO:2001234 9.66 BAX BCL2
24 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.66 BCL2 TP53
25 B cell homeostasis GO:0001782 9.65 BAX BCL2
26 apoptotic mitochondrial changes GO:0008637 9.65 BAX BCL2
27 release of cytochrome c from mitochondria GO:0001836 9.65 BAX BCL2
28 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.65 BAX PCNA TP53
29 cellular sodium ion homeostasis GO:0006883 9.64 ATP12A ATP4A
30 positive regulation of protein oligomerization GO:0032461 9.64 BAX TP53
31 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.63 BAX BCL2
32 cellular response to UV GO:0034644 9.63 BAX PCNA TP53
33 cellular potassium ion homeostasis GO:0030007 9.61 ATP12A ATP4A
34 sodium ion export across plasma membrane GO:0036376 9.61 ATP12A ATP4A
35 regulation of mitochondrial membrane permeability GO:0046902 9.58 BCL2 TP53
36 ovarian follicle development GO:0001541 9.58 BAX BCL2 VEGFA
37 positive regulation of cellular component movement GO:0051272 9.57 BCL6 VEGFA
38 regulation of protein heterodimerization activity GO:0043497 9.56 BAX BCL2
39 B cell apoptotic process GO:0001783 9.55 BAX BCL10
40 regulation of protein homodimerization activity GO:0043496 9.54 BAX BCL2
41 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.54 BAX BCL2 TP53
42 leukocyte homeostasis GO:0001776 9.51 BAX BCL2
43 regulation of apoptotic process GO:0042981 9.35 BAX BCL10 BCL2 BCL6 TP53
44 response to gamma radiation GO:0010332 9.33 BAX BCL2 TP53
45 positive regulation of developmental pigmentation GO:0048087 9.32 BAX BCL2
46 regulation of nitrogen utilization GO:0006808 9.26 BAX BCL2
47 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.8 ATP12A ATP4A BAX

Molecular functions related to Gastric Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.71 BAX BCL2 TP53 VEGFA
2 chaperone binding GO:0051087 9.5 ALB BAX TP53
3 channel activity GO:0015267 9.48 BAX BCL2
4 histone acetyltransferase binding GO:0035035 9.46 PCNA TP53
5 protein phosphatase 2A binding GO:0051721 9.43 BCL2 TP53
6 protease binding GO:0002020 9.43 BCL10 BCL2 TP53
7 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP12A ATP4A
8 identical protein binding GO:0042802 9.23 ALB BAX BCL10 BCL2 BCL6 PCNA
9 BH3 domain binding GO:0051434 9.16 BAX BCL2
10 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Gastric Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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