Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: GST027
MIFTS: 43

Gastric Lymphoma

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Gastric Lymphoma

About this section

MalaCards integrated aliases for Gastric Lymphoma:

Name: Gastric Lymphoma 12 73 20 29 54 15 70
Familial Primary Gastric Lymphoma 20 70
Primary Gastric Lymphoma 20
Lymphoma of the Stomach 12

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Genetic diseases
Anatomical: Immune diseases Blood diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10540
NCIt 50 C4636
SNOMED-CT 67 276811008
UMLS 70 C0349532 C1850900
Sources

Summaries for Gastric Lymphoma

About this section
MalaCards based summary : Gastric Lymphoma, also known as familial primary gastric lymphoma, is related to lymphoma, hodgkin, classic and nodal marginal zone lymphoma. An important gene associated with Gastric Lymphoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and NF-kappaB Signaling. The drugs Clarithromycin and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and myeloid, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Primary gastric lymphoma (lymphoma that originates in the stomach itself) is an uncommon condition,... more...

Sources

Related Diseases for Gastric Lymphoma

About this section

Diseases related to Gastric Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 lymphoma, hodgkin, classic 30.5 IRF4 ICOSLG BCL6
2 nodal marginal zone lymphoma 30.3 IRF4 IGHV4-38-2 BCL6
3 peripheral t-cell lymphoma 30.3 TP53 CXCL13 BCL6
4 primary central nervous system lymphoma 30.3 CXCR5 CXCL13 BCL6
5 peptic ulcer disease 30.2 TP53 S100A8 ATP4A ATP12A
6 gastrointestinal lymphoma 30.2 MALT1 CD79A BCL6
7 lymphocytic gastritis 30.2 ATP4A ATP12A
8 granulomatous gastritis 30.2 ATP4A ATP12A
9 follicular lymphoma 30.1 IRF4 CXCR5 BCL6 BCL10
10 diffuse large b-cell lymphoma 30.1 TP53 MALT1 IRF4 CD79A BCL6 BCL10
11 active peptic ulcer disease 30.0 ATP4A ATP12A ALB
12 lymphoblastic lymphoma 30.0 TP53 CD7 BCL6
13 adult t-cell leukemia 30.0 TP53 IRF4 CD7
14 microinvasive gastric cancer 29.9 TP53 S100A8 ATP4A ATP12A
15 b-cell lymphoma 29.8 TP53 MALT1 IRF4 CXCR5 CXCL13 BIRC3
16 lymphoma 29.8 TP53 MALT1 IRF4 CXCR5 CXCL13 BIRC3
17 adult lymphoma 29.8 IRF4 BCL6
18 mantle cell lymphoma 29.8 TP53 MALT1 CXCR5 BCL6 BCL10
19 paralytic ileus 29.7 ATP4A ATP12A ALB
20 pleural empyema 29.7 CD79A BCL6 ALB
21 intestinal obstruction 29.7 ATP4A ATP12A ALB
22 central nervous system lymphoma 29.7 TP53 MALT1 CXCR5 CXCL13 BCL6
23 acquired immunodeficiency syndrome 29.5 TP53 CXCR5 CD79A BCL6 ALB
24 composite lymphoma 29.5 IGHV4-38-2 CD79A BCL6
25 burkitt lymphoma 29.5 TP53 IRF4 CXCR5 CXCL13 BIRC3 BCL6
26 vitamin b12 deficiency 29.4 CD79A ATP4A ATP12A
27 richter's syndrome 29.4 TP53 IRF4 IGHV4-38-2
28 lymphoplasmacytic lymphoma 29.2 IGHV4-38-2 CD79A BCL6
29 duodenitis 29.1 S100A8 MALT1 ATP4A ATP12A ALB
30 deficiency anemia 28.9 IRF4 ICOSLG CD7 ATP4A ATP12A ALB
31 lymphoma, mucosa-associated lymphoid type 28.8 TP53 S100A8 MALT1 IRF4 IGHV4-38-2 ICOSLG
32 lymphoma, non-hodgkin, familial 28.0 TP53 MALT1 IRF4 IGHV4-38-2 ICOSLG CXCR5
33 marginal zone b-cell lymphoma 27.8 S100A8 MALT1 IRF4 IGHV4-38-2 CD79A BIRC3
34 leukemia, chronic lymphocytic 27.4 TP53 IRF4 IGHV4-38-2 ICOSLG CXCR5 CD79A
35 gastric non-hodgkin lymphoma 11.1
36 helicobacter pylori infection 10.6
37 gastritis 10.6
38 gastric adenocarcinoma 10.4
39 primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma 10.4 CXCR5 BCL6
40 neurosyphilis 10.3 CXCR5 CXCL13
41 meningovascular neurosyphilis 10.3 CXCL13 ALB
42 plasmablastic lymphoma 10.3
43 nodal marginal zone b-cell lymphoma 10.3 MALT1 BCL6
44 granulomatous hepatitis 10.3 CCL21 ALB
45 primary mediastinal large b-cell lymphoma 10.2 IRF4 BCL6
46 vagus nerve disease 10.2 ATP4A ATP12A
47 bladder lymphoma 10.2 CD79A BCL6
48 splenic abscess 10.2 ATP12A ALB
49 necrotizing gastritis 10.2 ATP4A ATP12A
50 scalp dermatosis 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastric Lymphoma:



Diseases related to Gastric Lymphoma
Sources

Symptoms & Phenotypes for Gastric Lymphoma

About this section

MGI Mouse Phenotypes related to Gastric Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 ATP4A BCL10 BCL6 BIRC3 CCL21 CD7
2 immune system MP:0005387 9.44 ALB ATP4A BCL10 BCL6 BIRC3 CCL21
Sources

Drugs & Therapeutics for Gastric Lymphoma

About this section

Drugs for Gastric Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 3 81103-11-9 84029
2
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
3
Chlorambucil Approved Phase 3 305-03-3 2708
4
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
5 Cytochrome P-450 CYP3A Inhibitors Phase 3
6 Antiparasitic Agents Phase 3
7 Anti-Bacterial Agents Phase 3
8 Antiprotozoal Agents Phase 3
9 Proton Pump Inhibitors Phase 3
10 Anti-Infective Agents Phase 3
11 Cytochrome P-450 Enzyme Inhibitors Phase 3
12 Antacids Phase 3
13 Anti-Ulcer Agents Phase 3
14 Gastrointestinal Agents Phase 3
15 Alkylating Agents Phase 3
16
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
17
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
18
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
19
rituximab Approved Phase 2 174722-31-7 10201696
20
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
21
Metronidazole Approved Phase 2 443-48-1 4173
22
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
23
Tetracycline Approved, Vet_approved Phase 2 60-54-8 5353990
24 Antirheumatic Agents Phase 2
25
Liposomal doxorubicin Phase 2 31703
26 Antineoplastic Agents, Immunological Phase 2
27 Immunologic Factors Phase 2
28 Antibiotics, Antitubercular Phase 2
29
Bismuth Phase 2 7440-69-9 16682734 105143
30 Bismuth tripotassium dicitrate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Low-Grade Gastric Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Type Stages IE & II1E (HELYX-Study) Unknown status NCT00154440 Phase 3 proton pump inhibitor;clarithromycin;amoxicillin;metronidazole
2 Protocol for a Randomised Trial of Observation Versus Chlorambucil After Anti-Helicobacter Therapy in Low Grade Gastric Lymphoma Unknown status NCT00003617 Phase 3 chlorambucil;clarithromycin;omeprazole;tinidazole
3 Phase II Study With Rituximab and CHOP in Patients With Gastric Diffuse Large B-Cell Non-Hodgkin's Lymphoma Completed NCT00204659 Phase 2 Rituximab + CHOP chemotherapy
4 A Phase II Clinical Trial of Anti-Helicobacter Pylori Treatment in Endoscopically Diagnosed Low-Grade Localized Gastric Lymphoma Completed NCT00003151 Phase 2 amoxicillin;clarithromycin;metronidazole hydrochloride;omeprazole;tetracycline hydrochloride

Search NIH Clinical Center for Gastric Lymphoma

Sources

Genetic Tests for Gastric Lymphoma

About this section

Genetic tests related to Gastric Lymphoma:

# Genetic test Affiliating Genes
1 Gastric Lymphoma 29
Sources

Anatomical Context for Gastric Lymphoma

About this section

MalaCards organs/tissues related to Gastric Lymphoma:

40
Liver, Bone, Myeloid, Skin, Colon, Bone Marrow, Eye
Sources

Publications for Gastric Lymphoma

About this section

Articles related to Gastric Lymphoma:

(show top 50) (show all 1282)
# Title Authors PMID Year
1
[Gastric lymphoma. Morphological and immunohistochemical study]. 54 61
18677925 2008
2
High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma. 61 54
16772602 2006
3
Helicobacter pylori and gastric lymphoma: high seroprevalence of CagA in diffuse large B-cell lymphoma but not in low-grade lymphoma of mucosa-associated lymphoid tissue type. 54 61
11513169 2001
4
BCL10 somatic mutations rarely occur in gastric lymphoma: detection of high frequency of polymorphisms in BCL10 coding region. 54 61
11425462 2001
5
Mutational analysis of the 5' noncoding region of the bcl-6 gene in primary gastric lymphomas. 61 54
11353050 2001
6
Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease. 54 61
11316139 2001
7
Mutation of the 5' noncoding region of the BCL-6 gene in low-grade gastric lymphoma of the mucosa-associated lymphoid tissue. 61 54
9546062 1998
8
Aggressive primary gastric lymphoma (PGL) masquerading as hepatocellular cancer (HCC) in alcoholic cirrhosis. 61
33663398 2021
9
Biophysical Analysis of Acute and Late Toxicity of Radiotherapy in Gastric Marginal Zone Lymphoma-Impact of Radiation Dose and Planning Target Volume. 61
33808548 2021
10
Eruptive lichen planus-like keratoses induced during R-CHOP 21 chemotherapy for diffuse large B-cell (gastric) lymphoma. 61
33660843 2021
11
A Heterogeneity Radiomic Nomogram for Preoperative Differentiation of Primary Gastric Lymphoma From Borrmann Type IV Gastric Cancer. 61
33273161 2021
12
Difficulty in distinguishing malignant gastric lymphoma from advanced gastric cancer: Focusing on endoscopic findings of the Borrmann type. 61
33607858 2021
13
PTEN Loss and Cyclin A2 Upregulation Define a PI3K/AKT Pathway Activation in Helicobacter pylori-induced MALT and DLBCL Gastric Lymphoma With Features of MALT. 61
32134755 2021
14
Expression of HSP60 in gastric lymphoma treated by a combination of trichosanthin and radiotherapy and its mechanism. 61
33500097 2021
15
Targeting the neighbour: Primary gastric lymphoma with concealed splenic perforation. 61
33475573 2020
16
Absolute Monocyte and Platelet Counts May Provide Additional Prognostic Information in Primary Gastric Diffuse Large B-cell Lymphoma Patients Treated with Rituximab and CHOP. 61
33415923 2020
17
Multiple metabolic parameters and visual assessment of 18F-FDG uptake heterogeneity of PET/CT in advanced gastric cancer and primary gastric lymphoma. 61
32274551 2020
18
Differentiating gastric cancer and gastric lymphoma using texture analysis (TA) of positron emission tomography (PET). 61
33230019 2020
19
First Line Systemic Treatment for MALT Lymphoma-Do We Still Need Chemotherapy? Real World Data from the Medical University Vienna. 61
33256131 2020
20
Primary gastric lymphoma: A report of 16 pediatric cases treated at a single institute and review of the literature. 61
32705927 2020
21
Prevalence and clinical relevance of hypercobalaminaemia in dogs and cats. 61
33129556 2020
22
Is mucosa-associated lymphoid tissue lymphoma an infectious disease? Role of Helicobacter pylori and eradication antibiotic therapy (Review). 61
32905014 2020
23
Value of staging information provided by linear-array endoscopic ultrasound for therapeutic response and prognosis prediction in gastric lymphoma. 61
33124105 2020
24
De Novo Antral Stenosis After Chemotherapy for Primary Malignant Gastric Lymphoma. 61
33125275 2020
25
Secondary gastric lymphoma - Do we know its endoscopic findings? 61
32755150 2020
26
[Helicobacter pylori related chronic inflammation and gastric lymphoma pathogenesis and progression]. 61
32892576 2020
27
Surveilling Russell body Helicobacter pylori-negative gastritis: A case report and review of literature. 61
32952348 2020
28
Decreased heart dose with deep inspiration breath hold for the treatment of gastric lymphoma with IMRT. 61
32642563 2020
29
Has-miR-17 increases the malignancy of gastric lymphoma by HSP60/TNFR2 pathway. 61
32924373 2020
30
Gastrointestinal Hemorrhage due to Large B-Cell Lymphoma Treated With Hemospray. 61
32656041 2020
31
Perineuritis or infiltration of optic nerve sheath? A presentation of diffuse large B cell Gastric lymphoma. 61
32461486 2020
32
Gastric lymphoma complicated by phlegmonous gastritis and Guillain-Barré syndrome: A case report. 61
32358382 2020
33
Onset and Progression of Precancerous Lesions on Gastric Mucosa of Patients Treated for Gastric Lymphoma. 61
32176756 2020
34
Heterogeneity of clinical management of low-grade gastric lymphoma of mucosa-associated lymphoid tissue. An audit of 198 patients in Spain. 61
31787375 2020
35
Gastrointestinal Bleeding in a Patient With Gastric Lymphoma, Tuberculosis Enteritis, and Cytomegalovirus Enteritis. 61
32309509 2020
36
[Laparoscopic Partial Colectomy for Transverse Colon Cancer after Open Laparotomy for Gastric Cancer Resection]. 61
32381996 2020
37
Helicobacter pylori-Negative MALT Lymphoma Presenting as a Massive Recurrent Gastrointestinal Hemorrhage. 61
32583695 2020
38
Splenic lymphoma with complex gastro-spleno-diaphragmatic fistula: 3D laparoscopic multivisceral resection. The first literature case report. 61
33191193 2020
39
Gastrosplenocolic fistula secondary to non-Hodgkin B-cell lymphoma. 61
31976059 2020
40
Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin's Lymphoma of the Duodenum: A SEER Database Analysis. 61
32399459 2020
41
A Retrospective Analysis of Primary Gastrointestinal Non-Hodgkin Lymphomas: Clinical Features, Prognostic Factors and Treatment Outcomes. 61
32606752 2020
42
Gastric Cancer in History: A Perspective Interdisciplinary Study. 61
31978985 2020
43
The Epidemiology of Gastric Cancers in the Era of Helicobacter pylori Eradication: A Nationwide Cancer Registry-Based Study in Taiwan. 61
31350264 2019
44
Prolonged follow-up on lenalidomide-based treatment for mucosa-associated lymphoid tissue lymphoma (MALT lymphoma)-Real-world data from the Medical University of Vienna. 61
31283840 2019
45
Atypical Lymphoid Proliferations and Clonality in Helicobacter-associated Inflammatory Infiltrates in Children. 61
31261290 2019
46
Are Histopathological Changes of H. pylori Infection in Young Dyspeptic Patients Necessitate Endoscopy? 61
31949518 2019
47
Low-Stage Gastric MALT Lymphoma Causing Life-Threatening Upper Gastrointestinal Bleeding. 61
31616232 2019
48
Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan. 61
31177299 2019
49
Upper gastrointestinal bleeding caused by direct invasion of diffuse large B-cell lymphoma into the stomach in a patient with HIV infection: A case report. 61
31305432 2019
50
Antigen of 49.6-kDa subunitpili protein of Helicobacter pylori as a potential biomarker for early and rapid detection of the infection. 61
31439991 2019
Sources

Variations for Gastric Lymphoma

About this section
Sources

Expression for Gastric Lymphoma

About this section
Search GEO for disease gene expression data for Gastric Lymphoma.
Sources

Pathways for Gastric Lymphoma

About this section

Pathways related to Gastric Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
B cell receptor signaling pathway (KEGG) 36
Show member pathways
 11.95 MALT1 IRF4 CD79A BCL6 BCL10
2
NF-kappaB Signaling 4
11.61 MALT1 IRF4 CXCR5 CD79A BCL6 BCL10
3
Interleukin-4 and 13 signaling 65
11.6 TP53 IRF4 BCL6
4
NF-kappa B signaling pathway 36
11.57 MALT1 CCL21 BIRC3 BCL10
5
Innate Lymphoid Cell Differentiation Pathways 64
11.4 IRF4 CXCR5 CD7
6
IgA-Producing B Cells in the Intestine 64
11.08 ICOSLG CXCR5 CXCL13 BCL6
Sources

GO Terms for Gastric Lymphoma

About this section

Cellular components related to Gastric Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CBM complex GO:0032449 8.96 MALT1 BCL10
2 polkadots GO:0002096 8.62 MALT1 BCL10

Biological processes related to Gastric Lymphoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 TP53 MALT1 BIRC3 BCL6 ALB
2 regulation of inflammatory response GO:0050727 9.73 S100A8 BIRC3 BCL6
3 cell chemotaxis GO:0060326 9.72 CXCR5 CXCL13 CCL21
4 neutrophil chemotaxis GO:0030593 9.7 S100A8 CXCL13 CCL21
5 positive regulation of protein ubiquitination GO:0031398 9.67 MALT1 BIRC3 BCL10
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.67 MALT1 CCL21 BIRC3 BCL10
7 chemokine-mediated signaling pathway GO:0070098 9.65 CXCR5 CXCL13 CCL21
8 positive regulation of T cell chemotaxis GO:0010820 9.6 CXCL13 CCL21
9 sodium ion export across plasma membrane GO:0036376 9.59 ATP4A ATP12A
10 cellular potassium ion homeostasis GO:0030007 9.58 ATP4A ATP12A
11 positive regulation of histone deacetylation GO:0031065 9.58 TP53 BCL6
12 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.57 ATP4A ATP12A
13 chemotaxis GO:0006935 9.56 S100A8 CXCR5 CXCL13 CCL21
14 regulation of apoptotic process GO:0042981 9.55 TP53 MALT1 BIRC3 BCL6 BCL10
15 chronic inflammatory response GO:0002544 9.51 S100A8 CXCL13
16 T cell activation GO:0042110 9.5 IRF4 ICOSLG CD7
17 immune system process GO:0002376 9.5 S100A8 IRF4 ICOSLG CD79A CD7 BCL6
18 germinal center formation GO:0002467 9.46 CXCL13 BCL6
19 regulation of T cell receptor signaling pathway GO:0050856 9.43 MALT1 BCL10
20 response to fungus GO:0009620 9.4 MALT1 BCL10
21 B cell activation GO:0042113 8.92 MALT1 ICOSLG CXCR5 CD79A

Molecular functions related to Gastric Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 TP53 MALT1 ICOSLG CD79A BCL6 BCL10
2 protease binding GO:0002020 9.58 TP53 MALT1 BCL10
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 9.26 ATP4A ATP12A
5 kinase activator activity GO:0019209 9.16 MALT1 BCL10
6 protein self-association GO:0043621 9.13 TP53 MALT1 BCL10
7 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
Sources

Sources for Gastric Lymphoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....