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MCID: GST027
MIFTS: 53

Gastric Lymphoma

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Immune diseases, Genetic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Gastric Lymphoma

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MalaCards integrated aliases for Gastric Lymphoma:

Name: Gastric Lymphoma 12 76 53 29 55 15 73
Familial Primary Gastric Lymphoma 53 44 73
Primary Gastric Lymphoma 53
Lymphoma of the Stomach 12

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Genetic diseases
Anatomical: Gastrointestinal diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10540
MeSH 44 C535648
NCIt 50 C4636
SNOMED-CT 68 276811008
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Summaries for Gastric Lymphoma

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MalaCards based summary : Gastric Lymphoma, also known as familial primary gastric lymphoma, is related to lymphoma and lymphoma, mucosa-associated lymphoid type. An important gene associated with Gastric Lymphoma is BCL10 (B Cell CLL/Lymphoma 10), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of TP53 Activity. The drugs Amoxicillin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Primary gastric lymphoma (lymphoma that originates in the stomach itself) is an uncommon condition,... more...

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Related Diseases for Gastric Lymphoma

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Diseases related to Gastric Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 lymphoma 30.7 BAX BCL10 BCL2 BCL6
2 lymphoma, mucosa-associated lymphoid type 30.5 ATP12A ATP4A BCL10 BCL2 BCL6
3 diffuse large b-cell lymphoma 29.8 BCL10 BCL6 TP53
4 duodenitis 29.4 ATP12A ATP4A
5 granulomatous gastritis 29.2 ATP12A ATP4A
6 gastric adenocarcinoma 28.8 BAX BCL2 TP53 VEGFA
7 b-cell lymphomas 28.5 BAX BCL10 BCL2 BCL6 TP53
8 lymphoma, gastric non hodgkins type 11.0
9 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.7 BCL2 BCL6
10 nodal marginal zone b-cell lymphoma 10.7 BCL2 BCL6
11 mature teratoma 10.6 PCNA TP53
12 oral leukoplakia 10.6 PCNA TP53
13 intravascular large b-cell lymphoma 10.6 BCL2 BCL6
14 fibrillary astrocytoma 10.6 PCNA TP53
15 primary mediastinal large b-cell lymphoma 10.6 BCL2 BCL6
16 epidural neoplasm 10.6 BCL6 TP53
17 primary central nervous system lymphoma 10.6 BCL2 BCL6
18 human herpesvirus 8 10.5 BCL2 BCL6
19 cervical carcinosarcoma 10.5 BCL2 TP53
20 inverted papilloma 10.4 PCNA TP53
21 rh isoimmunization 10.4 ALB BCL10
22 kashin-beck disease 10.4 BAX BCL2
23 ulcerative stomatitis 10.4 ALB TP53
24 malignant teratoma 10.3 BAX BCL2
25 severe nonproliferative diabetic retinopathy 10.3 ALB VEGFA
26 primary effusion lymphoma 10.3 BCL6 VEGFA
27 lipodermatosclerosis 10.3 PCNA VEGFA
28 alk-negative anaplastic large cell lymphoma 10.3 BAX BCL2
29 acute t cell leukemia 10.3 BAX BCL10
30 follicular lymphoma 1 10.3 BCL10 BCL2 BCL6
31 acroosteolysis 10.3 ALB VEGFA
32 ovary adenocarcinoma 10.3 BAX TP53
33 marginal zone b-cell lymphoma 10.3 BCL10 BCL2 BCL6
34 background diabetic retinopathy 10.2 ALB VEGFA
35 hidradenocarcinoma 10.2 BCL2 TP53
36 follicular lymphoma 10.2 BCL10 BCL2 BCL6
37 cartilage-hair hypoplasia 10.2 BAX BCL2
38 testicular torsion 10.2 BCL2 PCNA TP53
39 mantle cell lymphoma 10.2 BCL2 BCL6 TP53
40 hypertensive nephropathy 10.2 ALB VEGFA
41 acinar cell carcinoma 10.2 BCL10 TP53
42 adenoid cystic carcinoma 10.1 BCL2 PCNA TP53
43 helicobacter pylori infection 10.1
44 adenocarcinoma 10.1
45 testicular germ cell tumor 10.1 BAX BCL10 TP53
46 gastritis 10.0
47 grade iii astrocytoma 10.0 PCNA TP53 VEGFA
48 primary peritoneal carcinoma 10.0 TP53 VEGFA
49 focal cortical dysplasia, type ii 10.0 BAX BCL2 TP53
50 keratocystic odontogenic tumor 10.0 BCL2 TP53

Graphical network of the top 20 diseases related to Gastric Lymphoma:



Diseases related to Gastric Lymphoma
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Symptoms & Phenotypes for Gastric Lymphoma

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GenomeRNAi Phenotypes related to Gastric Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 BCL2 PCNA TP53 BAX BCL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 BCL2 PCNA TP53 BAX BCL10

MGI Mouse Phenotypes related to Gastric Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.11 VEGFA ATP4A BCL6 BAX PCNA TP53
2 hematopoietic system MP:0005397 10.03 VEGFA ATP4A BCL6 BAX PCNA TP53
3 homeostasis/metabolism MP:0005376 10.01 VEGFA TP53 BCL2 ATP12A ATP4A BCL6
4 immune system MP:0005387 9.97 VEGFA ATP4A BCL6 BAX PCNA TP53
5 mortality/aging MP:0010768 9.97 VEGFA ATP4A BCL6 BAX PCNA TP53
6 digestive/alimentary MP:0005381 9.95 VEGFA TP53 ATP4A ALB BCL2 ATP12A
7 muscle MP:0005369 9.73 VEGFA TP53 BCL6 BAX ALB BCL2
8 neoplasm MP:0002006 9.55 VEGFA TP53 BAX ALB BCL2
9 renal/urinary system MP:0005367 9.43 VEGFA BAX TP53 ALB BCL2 ATP12A
10 reproductive system MP:0005389 9.1 VEGFA TP53 BCL2 BCL6 PCNA BAX
Sources

Drugs & Therapeutics for Gastric Lymphoma

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Drugs for Gastric Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
2
Clarithromycin Approved Phase 4,Phase 3,Phase 2 81103-11-9 84029
3
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
4
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
5 Antacids Phase 4,Phase 3,Phase 2
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2
8 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2
9 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2
10 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
11 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
12 Proton Pump Inhibitors Phase 4,Phase 3,Phase 2
13 Antibiotics, Antitubercular Phase 4,Phase 2
14
Chlorambucil Approved Phase 3,Phase 2 305-03-3 2708
15
Omeprazole Approved, Investigational, Vet_approved Phase 3,Phase 2 73590-58-6 4594
16
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
17
Metronidazole Approved Phase 3,Phase 2 443-48-1 4173
18 Alkylating Agents Phase 3,Phase 2
19 Antineoplastic Agents, Alkylating Phase 3,Phase 2
20 Antiparasitic Agents Phase 3,Phase 2
21 Antiprotozoal Agents Phase 3,Phase 2
22
Tetracycline Approved, Vet_approved Phase 2 60-54-8 5353990
23
Bismuth Subsalicylate Approved, Vet_approved Phase 2 14882-18-9 53629521
24
Loperamide Approved Phase 2 53179-11-6 3955
25
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
26
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
27
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
28
rituximab Approved Phase 2 174722-31-7 10201696
29
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
30
Lenalidomide Approved Phase 2 191732-72-6 216326
31
Doxil Approved June 1999 Phase 2 31703
32
Bismuth Phase 2 7440-69-9 16682734 105143
33 Bismuth tripotassium dicitrate Phase 2
34 Antidiarrheals Phase 2
35 Antitubercular Agents Phase 2
36 Antirheumatic Agents Phase 2
37 Angiogenesis Inhibitors Phase 2
38 Angiogenesis Modulating Agents Phase 2
39 Immunosuppressive Agents Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Intraluminal Therapy for Helicobacter Pylori Infection Completed NCT03124420 Phase 4 Lansoprazole;Amoxicillin;Clarithromycin
2 Intraluminal Amoxicillin Powder Monotherapy for Helicobacter Pylori Infection Recruiting NCT03521726 Phase 4 Amoxicillin;Rabeprazole, Amoxicillin
3 Intraluminal Clarithromycin Powder Monotherapy for Helicobacter Pylori Infection Recruiting NCT03516669 Phase 4 Clarithromycin;Amoxicillin, Clarithromycin
4 Intraluminal Metronidazole Powder Monotherapy for Helicobacter Pylori Infection Not yet recruiting NCT03524833 Phase 4 Metronidazole;Lansoprazole, Amoxicillin, Metronidazole
5 Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the Stomach Unknown status NCT00003617 Phase 3 chlorambucil;clarithromycin;omeprazole;tinidazole
6 Helicobacter – Lymphoma – Radiation Part I: Eradication, Part II: Radiation Unknown status NCT00154440 Phase 3 proton pump inhibitor;clarithromycin;amoxicillin;metronidazole
7 Antibiotic Therapy in Treating Patients With Low Grade Gastric Lymphoma Completed NCT00003151 Phase 2 amoxicillin;clarithromycin;metronidazole hydrochloride;omeprazole;tetracycline hydrochloride
8 Antibiotic Therapy and Antacids in Patients With Malt Lymphoma of the Stomach Completed NCT00002682 Phase 2 Amoxicillin;Bismuth Subsalicylate;Clarithromycin;Metronidazole Hydrochloride;Omeprazole;Tetracycline Hydrochloride
9 Phase II Study With Rituximab and Cyclophosphamide, Doxorubicin, Vincristine, Prednisone (CHOP) in Patients With Gastric Diffuse Large B-Cell Non-Hodgkin`s Lymphoma Completed NCT00204659 Phase 2 Rituximab + CHOP chemotherapy
10 Clarithromycin + Lenalidomide Combination: a Full Oral Treatment for Patients With Relapsed/Refractory Extranodal Marginal Zone Lymphoma Recruiting NCT03031483 Phase 2 clarithromycin and lenalidomide
11 Phase II Study of Chlorambucil and Subcutaneous Rituximab in Patients With Extranodal MALT Lymphoma Active, not recruiting NCT01808599 Phase 2 Chlorambucil;Rituximab i.v.;Rituximab s.c.
12 Immediate Detection of Helicobacter Infection With a New Electrochemical System. Unknown status NCT01234389 Not Applicable
13 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831

Search NIH Clinical Center for Gastric Lymphoma

Cochrane evidence based reviews: familial primary gastric lymphoma

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Genetic Tests for Gastric Lymphoma

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Genetic tests related to Gastric Lymphoma:

# Genetic test Affiliating Genes
1 Gastric Lymphoma 29 BCL10
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Anatomical Context for Gastric Lymphoma

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MalaCards organs/tissues related to Gastric Lymphoma:

41
B Cells, T Cells, Liver, Kidney, Pancreas, Lymph Node, Bone
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Publications for Gastric Lymphoma

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Articles related to Gastric Lymphoma:

(show top 50) (show all 439)
# Title Authors Year
1
Gastric inflammatory fibroid polyp tumor with acute intestinal obstruction-Vanek's tumor can mimick a giant gastrointestinal stromal tumor or a gastric lymphoma. ( 29682464 )
2018
2
Four-dimensional cone-beam computed tomography-guided radiotherapy for gastric lymphoma. ( 29086348 )
2018
3
Primary Gastric Lymphoma: Clinicopathological Profile. ( 29963454 )
2018
4
Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment. ( 29779412 )
2018
5
Severe upper gastrointestinal bleeding determined by a gastric lymphoma associated with Helicobacter pylori-positive atrophic gastritis. ( 28730251 )
2017
6
Gastric Kaposi's sarcoma simulating gastric lymphoma during endoscopic ultrasound examination. ( 28685740 )
2017
7
Isolated Pulmonary Valve Vegetations in a Patient with Gastric Lymphoma Diagnosed by Endoscopic Ultrasound. ( 29560679 )
2017
8
Gastric lymphoma: association with Helicobacter pylori outer membrane protein Q (HopQ) and cytotoxic-pathogenicity activity island (CPAI) genes. ( 29143724 )
2017
9
The Role of Endoscopic Ultrasound in the Diagnosis and Management of Primary Gastric Lymphoma. ( 28400819 )
2017
10
CT-based radiomics signature for differentiating Borrmann type IV gastric cancer from primary gastric lymphoma. ( 28629560 )
2017
11
Multimodality Treatment of Gastric Lymphoma. ( 28325194 )
2017
12
Clinical manifestations and endoscopic presentations of gastric lymphoma: a multicenter seven year retrospective survey. ( 28617031 )
2017
13
Diffuse large B cell gastric lymphoma a rare disease: the effort to obtain scientific data in a multicenter, multinational retrospective trial. ( 27521853 )
2016
14
Prognostic value of SUVmax measured by pretreatment 18F-FDG PET/CT in patients with primary gastric lymphoma. ( 27482643 )
2016
15
The clinical characteristics of primary gastric lymphoma detected during screening for gastric cancer in Korea. ( 26850225 )
2016
16
18F-FDG PET/CT Imaging of Primary Gastric Lymphoma. ( 27493260 )
2016
17
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography comparison of gastric lymphoma and gastric carcinoma. ( 27678362 )
2016
18
4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma : Determination of intra- and interfractional gastric motion. ( 26902523 )
2016
19
H. pylori-associated gastric lymphoma: Complete remission in an HIV-positive patient treated with HAART and H. pylori eradication therapy. ( 27206927 )
2016
20
Clinical characteristics and prognostic factors of primary gastric lymphoma: A retrospective study with 165 cases. ( 27495029 )
2016
21
Indication for liver transplantation in a patient with a history of a gastric lymphoma. ( 26937630 )
2016
22
High expression of PTPN21 in B-cell non-Hodgkin's gastric lymphoma, a positive mediator of STAT5 activity. ( 26771814 )
2016
23
Massive gastrointestinal bleeding after chemotherapy for gastric lymphoma. ( 26921535 )
2016
24
Survival of patients with gastric lymphoma in Germany and in the United States. ( 25967274 )
2015
25
Colonic inflammation in a samoan immigrant with gastric lymphoma shown by positron emission tomography. ( 25948555 )
2015
26
Primary gastric lymphoma in a soldier presenting as acute gastrointestinal bleeding. ( 28265419 )
2015
27
Refractory peptic ulceration following radiation therapy in primary gastric lymphoma: A report of two cases. ( 25435934 )
2015
28
Spontaneous regression of high grade primary gastric Lymphoma in an untreated viral hepatitis infection. ( 24512317 )
2014
29
Gastrocolic fistula secondary to primary gastric lymphoma. ( 24932326 )
2014
30
A retrospective study of feline gastric lymphoma in 16 chemotherapy-treated cats. ( 24216491 )
2014
31
Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy. ( 25161174 )
2014
32
Treatment modalities in primary gastric lymphoma: the effect of rituximab and surgical treatment. A study by the Anatolian Society of Medical Oncology. ( 25258586 )
2014
33
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography findings of gastric lymphoma: Comparisons with gastric cancer. ( 25202405 )
2014
34
Clinicopathological characteristics and therapeutic outcomes of synchronous gastric adenocarcinoma and gastric lymphoma. ( 25202092 )
2014
35
The evolving role of surgery for gastric lymphoma: from curative resection to surgical management of complications. ( 25347493 )
2014
36
Malignant gastric lymphoma with spontaneous perforation. ( 23329705 )
2013
37
Hepatic dysfunction after radiotherapy for primary gastric lymphoma. ( 23283868 )
2013
38
Primary Gastric Lymphoma Presenting as Acute Pancreatitis: A Case Report. ( 23846949 )
2013
39
Clonal immunoglobulin heavy chain and T-cell receptor I^ gene rearrangements in primary gastric lymphoma. ( 24039368 )
2013
40
Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma. ( 23425357 )
2013
41
Primary gastric lymphoma: utility of 18F-fluorodeoxyglucose positron emission tomography-computed tomography for detecting relapse after treatment. ( 23043310 )
2013
42
Predictive value of endoscopic ultrasound in diagnosis and staging of primary gastric lymphoma. ( 23837259 )
2013
43
Unconvincing diagnosis of a rare subtype of primary gastric lymphoma with incongruent endoscopic presentation: a case of gastric schwannoma. ( 24365735 )
2013
44
Review of the molecular profile and modern prognostic markers for gastric lymphoma: how do they affect clinical practice? ( 22564515 )
2012
45
Primary gastric lymphoma: conservative treatment modality is not inferior to surgery for early-stage disease. ( 22988526 )
2012
46
Correlational study of vascular endothelial growth factor expression and microvessel density in primary malignant gastric lymphoma. ( 21710234 )
2012
47
A case of eosinophilic gastroenteritis mimicking gastric lymphoma associated with pancreatitis due to duodenal involvement. ( 23161306 )
2012
48
The diagnostic characteristics of a group of patients with primary gastric lymphoma: macroscopic, histopathological and immunohistochemical aspects. ( 22732804 )
2012
49
The remarkably distensible stomach: Case report highlighting the implications of gastric filling on radiation treatment planning for gastric lymphoma. ( 24674162 )
2012
50
SUVmax/THKmax as a biomarker for distinguishing advanced gastric carcinoma from primary gastric lymphoma. ( 23226547 )
2012
Sources

Variations for Gastric Lymphoma

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Expression for Gastric Lymphoma

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Search GEO for disease gene expression data for Gastric Lymphoma.
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Pathways for Gastric Lymphoma

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Pathways related to Gastric Lymphoma according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 37
Show member pathways
 12.82 BAX BCL2 TP53 VEGFA
2
Regulation of TP53 Activity 66
Show member pathways
 12.8 BAX BCL6 PCNA TP53
3
Pathways in cancer 37
12.66 BAX BCL2 TP53 VEGFA
4
Endometrial cancer 37
Show member pathways
 12.62 BAX BCL2 PCNA TP53 VEGFA
5
Glioma 37
Show member pathways
 12.59 BAX BCL2 TP53 VEGFA
6
Chks in Checkpoint Regulation 64
Show member pathways
 12.51 BAX BCL2 PCNA TP53
7
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.24 BAX BCL2 PCNA TP53 VEGFA
8
DNA Damage Response 1
Show member pathways
 12.23 BAX BCL2 TP53
9
p53 Signaling 64
Show member pathways
 12.11 BAX BCL2 TP53
10
Transcriptional misregulation in cancer 37
12.1 BAX BCL6 TP53
11
Apoptosis and Autophagy 4
12.1 BAX BCL10 BCL2
12
Tuberculosis 37
12.08 BAX BCL10 BCL2
13
Colorectal Cancer Metastasis 64
12.02 BAX TP53 VEGFA
14
AKT Signaling Pathway 67
12.01 BAX BCL2 TP53
15
Fluid shear stress and atherosclerosis 37
11.93 BCL2 TP53 VEGFA
16
SMAD Signaling Network 64
11.91 BCL2 TP53 VEGFA
17
Development IGF-1 receptor signaling 22
Show member pathways
 11.87 BAX PCNA TP53
18
Activation of BH3-only proteins 66
Show member pathways
 11.86 BAX BCL2 TP53
19
Integrated Breast Cancer Pathway 1
11.86 BAX BCL2 TP53 VEGFA
20
Sphingolipid signaling pathway 37
11.83 BAX BCL2 TP53
21
Amyotrophic lateral sclerosis (ALS) 1 37
Show member pathways
 11.81 BAX BCL2 TP53
22
Senescence and Autophagy in Cancer 1
11.77 BCL2 PCNA TP53
23
TP53 Regulates Transcription of Cell Death Genes 66
Show member pathways
 11.76 BAX BCL6 TP53
24
TP53 Regulates Transcription of Cell Cycle Genes 66
Show member pathways
 11.73 BAX PCNA TP53
25
AGE-RAGE signaling pathway in diabetic complications 37
11.71 BAX BCL2 VEGFA
26
Small cell lung cancer 37
11.65 BAX BCL2 TP53
27
DNA Damage Response (only ATM dependent) 1
11.62 BAX BCL2 BCL6 TP53
28
Platinum drug resistance 37
11.53 BAX BCL2 TP53
29
Interleukin-4 and 13 signaling 66
11.51 BCL2 BCL6 TP53 VEGFA
30
Photodynamic therapy-induced AP-1 survival signaling. 1
11.34 BAX BCL2 TP53
31
Integrated Cancer Pathway 1
11.27 BAX BCL2 TP53
32
14-3-3 and Regulation of BAD Activity 64
11.18 BAX BCL2
33
GADD45 Pathway 64
11.18 PCNA TP53
34
Photodynamic therapy-induced HIF-1 survival signaling 1
11.15 BAX TP53 VEGFA
35
Direct p53 effectors 1
11.14 BAX BCL2 BCL6 PCNA TP53
36
BARD1 signaling events 1
11.13 PCNA TP53
37
Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 22
11.11 BAX BCL2
38
Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics 61
11 BAX BCL2
40
Overview of nanoparticle effects 1
10.9 BAX BCL2
41
Vinka Alkaloid Pathway, Pharmacokinetics 61
10.52 BAX BCL2
42
TP53 Network 1
Show member pathways
 10.47 BAX BCL2 TP53
Sources

GO Terms for Gastric Lymphoma

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Cellular components related to Gastric Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.46 ALB BCL10 BCL2 TP53
2 pore complex GO:0046930 8.96 BAX BCL2
3 replication fork GO:0005657 8.8 BCL6 PCNA TP53

Biological processes related to Gastric Lymphoma according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.94 BAX BCL2 BCL6 TP53
2 cell proliferation GO:0008283 9.9 BAX BCL2 PCNA TP53
3 positive regulation of apoptotic process GO:0043065 9.88 BAX BCL10 BCL6 TP53
4 negative regulation of apoptotic process GO:0043066 9.88 ALB BCL2 BCL6 TP53 VEGFA
5 cytokine-mediated signaling pathway GO:0019221 9.86 BCL2 BCL6 TP53 VEGFA
6 cellular response to DNA damage stimulus GO:0006974 9.83 BAX BCL2 BCL6 PCNA TP53
7 negative regulation of cell growth GO:0030308 9.8 BCL2 BCL6 TP53
8 cellular response to hypoxia GO:0071456 9.78 BCL2 TP53 VEGFA
9 kidney development GO:0001822 9.77 BAX BCL2 VEGFA
10 neuron apoptotic process GO:0051402 9.71 BAX BCL2
11 cellular response to glucose starvation GO:0042149 9.7 BCL2 TP53
12 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.7 BAX TP53
13 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.7 BAX BCL2
14 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.7 BAX BCL2
15 negative regulation of fibroblast proliferation GO:0048147 9.69 BAX TP53
16 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.69 BCL2 TP53
17 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.69 BAX BCL2
18 intrinsic apoptotic signaling pathway GO:0097193 9.68 BAX TP53
19 ATP hydrolysis coupled proton transport GO:0015991 9.68 ATP12A ATP4A
20 cell aging GO:0007569 9.68 BCL2 TP53
21 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.68 BAX TP53
22 regulation of mitochondrial membrane potential GO:0051881 9.67 BAX BCL2
23 homeostasis of number of cells within a tissue GO:0048873 9.67 BAX BCL2
24 release of cytochrome c from mitochondria GO:0001836 9.67 BAX BCL2
25 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.67 BAX PCNA TP53
26 negative regulation of apoptotic signaling pathway GO:2001234 9.66 BAX BCL2
27 B cell homeostasis GO:0001782 9.66 BAX BCL2
28 apoptotic mitochondrial changes GO:0008637 9.65 BAX BCL2
29 cellular sodium ion homeostasis GO:0006883 9.65 ATP12A ATP4A
30 positive regulation of protein oligomerization GO:0032461 9.65 BAX TP53
31 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.64 BAX BCL2
32 cellular potassium ion homeostasis GO:0030007 9.63 ATP12A ATP4A
33 sodium ion export across plasma membrane GO:0036376 9.63 ATP12A ATP4A
34 cellular response to UV GO:0034644 9.63 BAX PCNA TP53
35 growth GO:0040007 9.62 BCL2 VEGFA
36 regulation of mitochondrial membrane permeability GO:0046902 9.61 BCL2 TP53
37 positive regulation of histone deacetylation GO:0031065 9.58 BCL6 TP53
38 ovarian follicle development GO:0001541 9.58 BAX BCL2 VEGFA
39 positive regulation of cellular component movement GO:0051272 9.57 BCL6 VEGFA
40 regulation of protein heterodimerization activity GO:0043497 9.55 BAX BCL2
41 regulation of protein homodimerization activity GO:0043496 9.54 BAX BCL2
42 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.54 BAX BCL2 TP53
43 B cell apoptotic process GO:0001783 9.52 BAX BCL10
44 leukocyte homeostasis GO:0001776 9.51 BAX BCL2
45 regulation of apoptotic process GO:0042981 9.35 BAX BCL10 BCL2 BCL6 TP53
46 response to gamma radiation GO:0010332 9.33 BAX BCL2 TP53
47 regulation of nitrogen utilization GO:0006808 9.32 BAX BCL2
48 positive regulation of developmental pigmentation GO:0048087 9.26 BAX BCL2
49 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.8 ATP12A ATP4A BAX

Molecular functions related to Gastric Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.71 BAX BCL2 TP53 VEGFA
2 protease binding GO:0002020 9.5 BCL10 BCL2 TP53
3 channel activity GO:0015267 9.48 BAX BCL2
4 histone acetyltransferase binding GO:0035035 9.46 PCNA TP53
5 protein phosphatase 2A binding GO:0051721 9.43 BCL2 TP53
6 chaperone binding GO:0051087 9.43 ALB BAX TP53
7 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP12A ATP4A
8 identical protein binding GO:0042802 9.23 ALB BAX BCL10 BCL2 BCL6 PCNA
9 BH3 domain binding GO:0051434 9.16 BAX BCL2
10 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
Sources

Sources for Gastric Lymphoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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