MCID: GST004
MIFTS: 37

Gastric Neuroendocrine Neoplasm

Categories: Gastrointestinal diseases, Endocrine diseases, Rare diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Gastric Neuroendocrine Neoplasm

MalaCards integrated aliases for Gastric Neuroendocrine Neoplasm:

Name: Gastric Neuroendocrine Neoplasm 12 15 73
Gastric Neuroendocrine Tumor 59 73
Neuroendocrine Tumor of the Stomach 12
Neuroendocrine Tumor of Stomach 59
Net of Stomach 59
Gastric Net 59
Gnet 59

Characteristics:

Orphanet epidemiological data:

59
neuroendocrine tumor of stomach
Prevalence: 1-9/100000 (Europe),1-9/100000 (United States),1-9/1000000 (United Kingdom),1-9/1000000 (Japan);

Classifications:



Summaries for Gastric Neuroendocrine Neoplasm

MalaCards based summary : Gastric Neuroendocrine Neoplasm, also known as gastric neuroendocrine tumor, is related to neuroendocrine tumor and atrophic gastritis. An important gene associated with Gastric Neuroendocrine Neoplasm is ATRX (ATRX, Chromatin Remodeler), and among its related pathways/superpathways are Salivary secretion and Secretion of Hydrochloric Acid in Parietal Cells. Affiliated tissues include liver, and related phenotypes are weight loss and iron deficiency anemia

Related Diseases for Gastric Neuroendocrine Neoplasm

Diseases related to Gastric Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 29.8 CHGA GAST SST
2 atrophic gastritis 29.3 CHGA GAST SST
3 gastritis 29.1 CHGA GAST
4 clear cell sarcoma 10.9
5 melanoma of soft tissue 10.9
6 nodular ganglioneuroblastoma 10.4 ATRX CHGA
7 adenoma of the pancreas 10.4 CHGA SST
8 pylorospasm 10.4 GAST SST
9 gastrointestinal neuroendocrine tumor 10.4 CHGA SST
10 postcholecystectomy syndrome 10.3 GAST SST
11 pituitary carcinoma 10.3 CHGA SST
12 alpha-thalassemia/mental retardation syndrome, x-linked 10.3 ATRX DAXX
13 glucagonoma 10.3 CHGA SST
14 autoimmune atrophic gastritis 10.3 CHGA GAST
15 duodenogastric reflux 10.3 GAST SST
16 pancreatoblastoma 10.3 CHGA SST
17 carcinoid tumors, intestinal 10.3 CHGA SST
18 retinitis pigmentosa 40 10.3 GAST SST
19 goblet cell carcinoid 10.3 CHGA GAST
20 pancreatic cholera 10.3 GAST SST
21 somatostatinoma 10.3 CHGA SST
22 pernicious anemia 10.2 GAST SST
23 binswanger's disease 10.2 CHGA SST
24 carcinoid syndrome 10.2 CHGA SST
25 non-functioning pancreatic endocrine tumor 10.2 CHGA GAST
26 phaeochromocytoma 10.1 CHGA SST
27 alpha-thalassemia 10.1 ATRX DAXX
28 cell type benign neoplasm 10.1 CHGA SST
29 duodenal ulcer 10.0 GAST SST
30 merkel cell carcinoma 10.0 CHGA SST
31 paraganglioma 10.0 CHGA SST
32 constipation 9.9 GAST SST
33 fungal esophagitis 9.8 ATP12A ATP4A
34 bladder calculus 9.8 ATP12A ATP4A
35 neonatal candidiasis 9.8 ATP12A ATP4A
36 photoallergic dermatitis 9.8 ATP12A ATP4A
37 squamous papillomatosis 9.8 ATP12A ATP4A
38 acute laryngitis 9.8 ATP12A ATP4A
39 gastroduodenal crohn's disease 9.8 ATP12A ATP4A
40 toxic megacolon 9.8 ATP12A ATP4A
41 aspiration pneumonitis 9.8 ATP12A ATP4A
42 postsurgical hypothyroidism 9.8 ATP12A ATP4A
43 esophageal candidiasis 9.8 ATP12A ATP4A
44 rumination disorder 9.8 ATP12A ATP4A
45 bile reflux 9.8 ATP12A ATP4A
46 amyotrophic lateral sclerosis 1 9.8
47 active peptic ulcer disease 9.8 ATP12A ATP4A
48 laryngeal disease 9.8 ATP12A ATP4A
49 insulinoma 9.8 CHGA SST
50 ischemic neuropathy 9.8 ATP12A ATP4A

Graphical network of the top 20 diseases related to Gastric Neuroendocrine Neoplasm:



Diseases related to Gastric Neuroendocrine Neoplasm

Symptoms & Phenotypes for Gastric Neuroendocrine Neoplasm

Human phenotypes related to Gastric Neuroendocrine Neoplasm:

59 32 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
2 iron deficiency anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001891
3 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
4 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
5 intermittent diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002254
6 episodic abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002574
7 poor appetite 59 32 frequent (33%) Frequent (79-30%) HP:0004396
8 dermatological manifestations of systemic disorders 59 32 occasional (7.5%) Occasional (29-5%) HP:0001005
9 zollinger-ellison syndrome 59 32 occasional (7.5%) Occasional (29-5%) HP:0002044
10 hepatomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0002240
11 hematemesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002248
12 melena 59 32 occasional (7.5%) Occasional (29-5%) HP:0002249
13 chronic noninfectious lymphadenopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002730
14 elevated hepatic transaminases 59 32 occasional (7.5%) Occasional (29-5%) HP:0002910
15 lack of bowel sounds 59 32 occasional (7.5%) Occasional (29-5%) HP:0030145
16 atypical pulmonary carcinoid tumor 59 32 occasional (7.5%) Occasional (29-5%) HP:0030446
17 hepatic failure 59 32 very rare (1%) Very rare (<4-1%) HP:0001399
18 right ventricular failure 59 32 very rare (1%) Very rare (<4-1%) HP:0001708
19 palpitations 59 32 very rare (1%) Very rare (<4-1%) HP:0001962
20 hypotension 59 32 very rare (1%) Very rare (<4-1%) HP:0002615
21 paraganglioma 59 32 very rare (1%) Very rare (<4-1%) HP:0002668
22 increased serum serotonin 59 32 very rare (1%) Very rare (<4-1%) HP:0003144
23 increased circulating acth level 59 32 very rare (1%) Very rare (<4-1%) HP:0003154
24 protracted diarrhea 59 32 very rare (1%) Very rare (<4-1%) HP:0004385
25 tricuspid regurgitation 59 32 very rare (1%) Very rare (<4-1%) HP:0005180
26 facial telangiectasia 59 32 very rare (1%) Very rare (<4-1%) HP:0007380
27 bowel urgency 59 32 very rare (1%) Very rare (<4-1%) HP:0012701
28 bronchospasm 59 32 very rare (1%) Very rare (<4-1%) HP:0025428
29 cardiogenic shock 59 32 very rare (1%) Very rare (<4-1%) HP:0030149
30 abnormal pulmonary valve cusp morphology 59 32 very rare (1%) Very rare (<4-1%) HP:0031566
31 carcinoid tumor 59 Obligate (100%)
32 bloody diarrhea 59 Occasional (29-5%)

GenomeRNAi Phenotypes related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 ATP4A ATRX CHGA DAXX

Drugs & Therapeutics for Gastric Neuroendocrine Neoplasm

Search Clinical Trials , NIH Clinical Center for Gastric Neuroendocrine Neoplasm

Genetic Tests for Gastric Neuroendocrine Neoplasm

Anatomical Context for Gastric Neuroendocrine Neoplasm

MalaCards organs/tissues related to Gastric Neuroendocrine Neoplasm:

41
Liver

Publications for Gastric Neuroendocrine Neoplasm

Articles related to Gastric Neuroendocrine Neoplasm:

# Title Authors Year
1
A Case of Gastric Neuroendocrine Neoplasm with Mixed Grade: a Distinct Type of &amp;quot;High&amp;quot;-grade Well-Differentiated Neuroendocrine Neoplasm. ( 29675587 )
2018
2
Gastric neuroendocrine neoplasm with liver metastases: a case report. ( 28138622 )
2016
3
Clinical management of patients with gastric neuroendocrine neoplasms associated with chronic atrophic gastritis: a retrospective, multicentre study. ( 25814125 )
2015
4
Mucin phenotype expression of gastric neuroendocrine neoplasms: analysis of histopathology and carcinogenesis. ( 23828549 )
2014
5
Gastric neuroendocrine neoplasms: tumour clonality and malignancy-associated large X-chromosomal deletions. ( 10547602 )
1999

Variations for Gastric Neuroendocrine Neoplasm

Expression for Gastric Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Gastric Neuroendocrine Neoplasm.

Pathways for Gastric Neuroendocrine Neoplasm

Pathways related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 ATP4A GAST SST
2 9.32 ATP4A GAST

GO Terms for Gastric Neuroendocrine Neoplasm

Cellular components related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF superfamily-type complex GO:0070603 8.62 ATRX DAXX

Biological processes related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.37 ATP12A ATP4A
2 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
4 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
5 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Gastric Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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