GNET
MCID: GST004
MIFTS: 46

Gastric Neuroendocrine Neoplasm (GNET)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Gastric Neuroendocrine Neoplasm

MalaCards integrated aliases for Gastric Neuroendocrine Neoplasm:

Name: Gastric Neuroendocrine Neoplasm 12 15 73
Gastric Neuroendocrine Tumor 59 73
Neuroendocrine Tumor of the Stomach 12
Neuroendocrine Tumor of Stomach 59
Net of Stomach 59
Gastric Net 59
Gnet 59

Characteristics:

Orphanet epidemiological data:

59
neuroendocrine tumor of stomach
Prevalence: 1-9/100000 (Europe),1-9/100000 (United States),1-9/1000000 (United Kingdom),1-9/1000000 (Japan);

Classifications:



Summaries for Gastric Neuroendocrine Neoplasm

MalaCards based summary : Gastric Neuroendocrine Neoplasm, also known as gastric neuroendocrine tumor, is related to neuroendocrine tumor and gastrinoma. An important gene associated with Gastric Neuroendocrine Neoplasm is ATRX (ATRX, Chromatin Remodeler), and among its related pathways/superpathways are Salivary secretion and Gastric acid production. The drugs Feridex I.V. and GastroMARK have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and skin, and related phenotypes are nausea and vomiting and hypotension

Related Diseases for Gastric Neuroendocrine Neoplasm

Diseases related to Gastric Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 30.0 CHGA GAST SST
2 gastrinoma 29.9 CHGA GAST SST
3 atrophic gastritis 29.9 CHGA GAST SST
4 microinvasive gastric cancer 29.8 ATP12A ATP4A
5 duodenal gastrinoma 29.8 CHGA GAST SST
6 autoimmune atrophic gastritis 29.8 CHGA GAST
7 multiple endocrine neoplasia, type i 29.8 CHGA GAST SST
8 zollinger-ellison syndrome 29.6 CHGA GAST SST
9 duodenal ulcer 29.6 GAST SST
10 clear cell sarcoma 11.1
11 melanoma of soft tissue 11.1
12 nodular ganglioneuroblastoma 10.2 ATRX CHGA
13 adenoma of the pancreas 10.2 CHGA SST
14 gastrointestinal neuroendocrine tumor 10.2 CHGA SST
15 pituitary carcinoma 10.2 CHGA SST
16 glucagonoma 10.2 CHGA SST
17 pancreatoblastoma 10.2 CHGA SST
18 carcinoid tumors, intestinal 10.2 CHGA SST
19 somatostatinoma 10.2 CHGA SST
20 binswanger's disease 10.1 CHGA SST
21 carcinoid syndrome 10.1 CHGA SST
22 pancreatic cystadenoma 10.1 CHGA SST
23 alpha-thalassemia/mental retardation syndrome, x-linked 10.1 ATRX DAXX
24 fungal esophagitis 10.1 ATP12A ATP4A
25 diclofenac allergy 10.1 ATP12A ATP4A
26 neonatal candidiasis 10.1 ATP12A ATP4A
27 photoallergic dermatitis 10.1 ATP12A ATP4A
28 squamous papillomatosis 10.1 ATP12A ATP4A
29 toxic megacolon 10.1 ATP12A ATP4A
30 aspiration pneumonitis 10.1 ATP12A ATP4A
31 esophageal candidiasis 10.1 ATP12A ATP4A
32 acute laryngitis 10.1 ATP12A ATP4A
33 laryngitis 10.1 ATP12A ATP4A
34 rumination disorder 10.1 ATP12A ATP4A
35 active peptic ulcer disease 10.1 ATP12A ATP4A
36 malignant pheochromocytoma 10.1 CHGA SST
37 congenital disorder of deglycosylation 10.1 ATP12A ATP4A
38 bladder calculus 10.1 ATP12A ATP4A
39 ischemic neuropathy 10.1 ATP12A ATP4A
40 bile reflux 10.1 ATP12A ATP4A
41 capillary disease 10.1 ATP12A ATP4A
42 peptic esophagitis 10.1 ATP12A ATP4A
43 dyskinesia of esophagus 10.1 ATP12A ATP4A
44 hernia, hiatus 10.1 ATP12A ATP4A
45 anismus 10.1 ATP12A ATP4A
46 postsurgical hypothyroidism 10.1 ATP12A ATP4A
47 esophageal atresia/tracheoesophageal fistula 10.1 ATP12A ATP4A
48 clostridium difficile colitis 10.1 ATP12A ATP4A
49 diarrhea 1, secretory chloride, congenital 10.1 ATP12A ATP4A
50 microscopic colitis 10.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Gastric Neuroendocrine Neoplasm:



Diseases related to Gastric Neuroendocrine Neoplasm

Symptoms & Phenotypes for Gastric Neuroendocrine Neoplasm

Human phenotypes related to Gastric Neuroendocrine Neoplasm:

59 32 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
2 hypotension 59 32 very rare (1%) Very rare (<4-1%) HP:0002615
3 hepatomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0002240
4 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
5 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
6 iron deficiency anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001891
7 zollinger-ellison syndrome 59 32 occasional (7.5%) Occasional (29-5%) HP:0002044
8 episodic abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002574
9 hematemesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002248
10 hepatic failure 59 32 very rare (1%) Very rare (<4-1%) HP:0001399
11 increased circulating acth level 59 32 very rare (1%) Very rare (<4-1%) HP:0003154
12 tricuspid regurgitation 59 32 very rare (1%) Very rare (<4-1%) HP:0005180
13 poor appetite 59 32 frequent (33%) Frequent (79-30%) HP:0004396
14 paraganglioma 59 32 very rare (1%) Very rare (<4-1%) HP:0002668
15 intermittent diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002254
16 palpitations 59 32 very rare (1%) Very rare (<4-1%) HP:0001962
17 cardiogenic shock 59 32 very rare (1%) Very rare (<4-1%) HP:0030149
18 right ventricular failure 59 32 very rare (1%) Very rare (<4-1%) HP:0001708
19 chronic noninfectious lymphadenopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002730
20 facial telangiectasia 59 32 very rare (1%) Very rare (<4-1%) HP:0007380
21 lack of bowel sounds 59 32 occasional (7.5%) Occasional (29-5%) HP:0030145
22 dermatological manifestations of systemic disorders 59 32 occasional (7.5%) Occasional (29-5%) HP:0001005
23 increased serum serotonin 59 32 very rare (1%) Very rare (<4-1%) HP:0003144
24 protracted diarrhea 59 32 very rare (1%) Very rare (<4-1%) HP:0004385
25 bowel urgency 59 32 very rare (1%) Very rare (<4-1%) HP:0012701
26 bronchospasm 59 32 very rare (1%) Very rare (<4-1%) HP:0025428
27 abnormal pulmonary valve cusp morphology 59 32 very rare (1%) Very rare (<4-1%) HP:0031566
28 melena 59 32 occasional (7.5%) Occasional (29-5%) HP:0002249
29 atypical pulmonary carcinoid tumor 59 32 occasional (7.5%) Occasional (29-5%) HP:0030446
30 elevated hepatic transaminases 59 Occasional (29-5%)
31 carcinoid tumor 59 Obligate (100%)
32 bloody diarrhea 59 Occasional (29-5%)
33 elevated hepatic transaminase 32 occasional (7.5%) HP:0002910

MGI Mouse Phenotypes related to Gastric Neuroendocrine Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 ATP12A ATRX CBLIF CHGA DAXX SST
2 digestive/alimentary MP:0005381 9.65 ATP12A ATP4A GAST SST TP63
3 homeostasis/metabolism MP:0005376 9.5 ATP12A ATP4A CBLIF CHGA GAST SST
4 mortality/aging MP:0010768 9.23 ATP4A ATRX CBLIF CHGA DAXX GAST

Drugs & Therapeutics for Gastric Neuroendocrine Neoplasm

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Feridex I.V. 18 FERUMOXIDES Advanced Magnetics February 1996
2
GastroMARK 18 FERUMOXSIL Advanced Magnetics May 1996
3
Ixempra 18 49 IXABEPILONE Bristol-Myers Squibb October 2007
4
Sutent 18 49 SUNITINIB MALATE Pfizer May 2011/ January 2006

Search Clinical Trials , NIH Clinical Center for Gastric Neuroendocrine Neoplasm

Genetic Tests for Gastric Neuroendocrine Neoplasm

Anatomical Context for Gastric Neuroendocrine Neoplasm

MalaCards organs/tissues related to Gastric Neuroendocrine Neoplasm:

41
Liver, Lung, Skin, Pituitary, Pancreas, Thyroid

Publications for Gastric Neuroendocrine Neoplasm

Articles related to Gastric Neuroendocrine Neoplasm:

# Title Authors Year
1
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. ( 30531243 )
2019
2
A Case of Gastric Neuroendocrine Neoplasm with Mixed Grade: a Distinct Type of &amp;quot;High&amp;quot;-grade Well-Differentiated Neuroendocrine Neoplasm. ( 29675587 )
2018
3
Gastric neuroendocrine neoplasm with late liver metastasis. ( 30083348 )
2018
4
Huge recurrent gastric neuroendocrine tumor: a second-line chemotherapeutic dilemma. ( 29515980 )
2018
5
An atypical type I gastric neuroendocrine tumor. ( 28710883 )
2017
6
Gastric neuroendocrine neoplasm with liver metastases: a case report. ( 28138622 )
2016

Variations for Gastric Neuroendocrine Neoplasm

Expression for Gastric Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Gastric Neuroendocrine Neoplasm.

Pathways for Gastric Neuroendocrine Neoplasm

Pathways related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.55 ATP4A GAST SST
2 9.8 CBLIF GAST
3 9.32 ATP4A GAST

GO Terms for Gastric Neuroendocrine Neoplasm

Cellular components related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ATP4A CBLIF CHGA GAST SST

Biological processes related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.43 ATP12A ATP4A
2 potassium ion import GO:0010107 9.4 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.37 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.32 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
8 chromatin remodeling GO:0006338 8.8 ATRX DAXX TP63

Molecular functions related to Gastric Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.16 DAXX TP63
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Gastric Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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