GNET
MCID: GST004
MIFTS: 36

Gastric Neuroendocrine Neoplasm (GNET)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Gastric Neuroendocrine Neoplasm

MalaCards integrated aliases for Gastric Neuroendocrine Neoplasm:

Name: Gastric Neuroendocrine Neoplasm 12 15 70
Gastric Neuroendocrine Tumor 58 70
Neuroendocrine Tumor of the Stomach 12
Neuroendocrine Tumor of Stomach 58
Net of Stomach 58
Gastric Net 58
Gnet 58

Characteristics:

Orphanet epidemiological data:

58
neuroendocrine tumor of stomach
Prevalence: 1-9/100000 (Europe),1-9/100000 (United States),1-9/1000000 (United Kingdom),1-9/1000000 (Japan);

Classifications:

Orphanet: 58  
Rare gastroenterological diseases
Rare endocrine diseases


Summaries for Gastric Neuroendocrine Neoplasm

MalaCards based summary : Gastric Neuroendocrine Neoplasm, also known as gastric neuroendocrine tumor, is related to autoimmune atrophic gastritis and pernicious anemia. An important gene associated with Gastric Neuroendocrine Neoplasm is ATRX (ATRX Chromatin Remodeler). The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, kidney and pancreas, and related phenotypes are nausea and vomiting and anorexia

Related Diseases for Gastric Neuroendocrine Neoplasm

Diseases related to Gastric Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 autoimmune atrophic gastritis 30.5 GAST CHGA
2 pernicious anemia 30.2 SST GAST CHGA
3 gastritis 30.1 SST GAST CHGA
4 zollinger-ellison syndrome 30.0 SST MEN1 GAST CHGA
5 pituitary tumors 29.9 SST MEN1
6 gastrinoma 29.9 SST MEN1 GAST CHGA
7 multiple endocrine neoplasia 29.9 SST MEN1 GAST CHGA
8 constipation 29.8 SST GAST CHGA
9 neuroendocrine tumor 29.7 SYP SST MEN1 GAST CHGA
10 atrophic gastritis 29.6 SST MEN1 GAST CHGA
11 duodenal gastrinoma 29.5 SST MEN1 GAST CHGA
12 adenoma 29.4 SYP SST MEN1 CHGA
13 multiple endocrine neoplasia, type i 29.3 SYP SST MEN1 GAST DAXX CHGA
14 neuroendocrine carcinoma 29.2 SYP SST MEN1 GAST CHGA
15 clear cell sarcoma 11.0
16 melanoma of soft tissue 10.9
17 goblet cell carcinoid 10.3 GAST CHGA
18 alpha-thalassemia/mental retardation syndrome, x-linked 10.2 DAXX ATRX
19 postgastrectomy syndrome 10.2 SST GAST
20 spinal cord oligodendroglioma 10.2 SYP ATRX
21 gastric antral vascular ectasia 10.2 SST GAST
22 alpha thalassemia-x-linked intellectual disability syndrome 10.2 DAXX ATRX
23 ectopic cushing syndrome 10.2 SST CHGA
24 primary hepatic neuroendocrine carcinoma 10.2 SYP CHGA
25 esophageal neuroendocrine tumor 10.2 SYP CHGA
26 auditory system benign neoplasm 10.2 SYP CHGA
27 auditory system cancer 10.2 SYP CHGA
28 acinar cell cystadenocarcinoma 10.2 SYP CHGA
29 vulvar eccrine porocarcinoma 10.2 SYP CHGA
30 pancreatic serous cystadenocarcinoma 10.2 SYP CHGA
31 cauda equina neoplasm 10.2 SYP CHGA
32 appendix carcinoid tumor 10.2 SYP CHGA
33 vaginal tubulovillous adenoma 10.2 SYP CHGA
34 laryngeal small cell carcinoma 10.2 SYP CHGA
35 gallbladder small cell carcinoma 10.2 SYP CHGA
36 ureter small cell carcinoma 10.2 SYP CHGA
37 papillary thymic adenocarcinoma 10.2 SYP CHGA
38 middle ear adenoma 10.2 SYP CHGA
39 urinary bladder small cell neuroendocrine carcinoma 10.2 SYP CHGA
40 gastric small cell carcinoma 10.2 SYP CHGA
41 breast papillary carcinoma 10.2 SYP CHGA
42 extracranial neuroblastoma 10.2 SYP CHGA
43 sensory organ benign neoplasm 10.2 SYP CHGA
44 cervical neuroblastoma 10.2 SYP CHGA
45 duodenogastric reflux 10.2 SST GAST
46 esophageal adenoid cystic carcinoma 10.2 SYP CHGA
47 ovarian large-cell neuroendocrine carcinoma 10.2 SYP CHGA
48 anal neuroendocrine tumor 10.2 SYP SST
49 appendix adenocarcinoma 10.2 SYP CHGA
50 subependymoma 10.2 SYP CHGA

Graphical network of the top 20 diseases related to Gastric Neuroendocrine Neoplasm:



Diseases related to Gastric Neuroendocrine Neoplasm

Symptoms & Phenotypes for Gastric Neuroendocrine Neoplasm

Human phenotypes related to Gastric Neuroendocrine Neoplasm:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
2 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
3 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
4 intermittent diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002254
5 poor appetite 58 31 frequent (33%) Frequent (79-30%) HP:0004396
6 iron deficiency anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001891
7 episodic abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002574
8 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
9 elevated hepatic transaminase 58 31 occasional (7.5%) Occasional (29-5%) HP:0002910
10 hematemesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002248
11 zollinger-ellison syndrome 58 31 occasional (7.5%) Occasional (29-5%) HP:0002044
12 chronic noninfectious lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002730
13 melena 58 31 occasional (7.5%) Occasional (29-5%) HP:0002249
14 lack of bowel sounds 58 31 occasional (7.5%) Occasional (29-5%) HP:0030145
15 dermatological manifestations of systemic disorders 58 31 occasional (7.5%) Occasional (29-5%) HP:0001005
16 atypical pulmonary carcinoid tumor 58 31 occasional (7.5%) Occasional (29-5%) HP:0030446
17 hypotension 58 31 very rare (1%) Very rare (<4-1%) HP:0002615
18 hepatic failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001399
19 tricuspid regurgitation 58 31 very rare (1%) Very rare (<4-1%) HP:0005180
20 facial telangiectasia 58 31 very rare (1%) Very rare (<4-1%) HP:0007380
21 paraganglioma 58 31 very rare (1%) Very rare (<4-1%) HP:0002668
22 increased circulating acth level 58 31 very rare (1%) Very rare (<4-1%) HP:0003154
23 palpitations 58 31 very rare (1%) Very rare (<4-1%) HP:0001962
24 right ventricular failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001708
25 cardiogenic shock 58 31 very rare (1%) Very rare (<4-1%) HP:0030149
26 increased serum serotonin 58 31 very rare (1%) Very rare (<4-1%) HP:0003144
27 bronchospasm 58 31 very rare (1%) Very rare (<4-1%) HP:0025428
28 protracted diarrhea 58 31 very rare (1%) Very rare (<4-1%) HP:0004385
29 bowel urgency 58 31 very rare (1%) Very rare (<4-1%) HP:0012701
30 abnormal pulmonary valve cusp morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0031566
31 carcinoid tumor 58 Obligate (100%)
32 bloody diarrhea 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Gastric Neuroendocrine Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.23 ATRX CHGA DAXX MEN1 SPEN SST

Drugs & Therapeutics for Gastric Neuroendocrine Neoplasm

Drugs for Gastric Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational 83150-76-9 6400441 383414
2
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
3 Antineoplastic Agents, Hormonal
4 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Observational Study Investigating Recurrence Rates of Type I Gastric Neuroendocrine Tumors Treated With Long-acting Somatostatin Analogs Unknown status NCT03812939 Octreotide

Search NIH Clinical Center for Gastric Neuroendocrine Neoplasm

Genetic Tests for Gastric Neuroendocrine Neoplasm

Anatomical Context for Gastric Neuroendocrine Neoplasm

MalaCards organs/tissues related to Gastric Neuroendocrine Neoplasm:

40
Lymph Node, Kidney, Pancreas, Thyroid

Publications for Gastric Neuroendocrine Neoplasm

Articles related to Gastric Neuroendocrine Neoplasm:

(show top 50) (show all 81)
# Title Authors PMID Year
1
An Incidental Uptake of 18F-Choline at PET/CT in Gastric Neuroendocrine Tumor. 61
33031248 2021
2
Risk factors for lymph node metastasis in gastric neuroendocrine tumor: a retrospective study. 61
33789664 2021
3
A rare case of multiple endocrine neoplasia type 1 initially presenting as an asymptomatic, huge mediastinal mass: case report. 61
33632163 2021
4
Single-incision laparoscopic antrectomy for type I gastric neuroendocrine tumor: a case report. 61
33433761 2021
5
Impact of endoscopic sedation on gastric polyp detection: A one-center retrospective observational study. 61
33031301 2020
6
Endoscopic submucosal dissection and tunneling procedures using a novel all-in-one bipolar device. 61
33015331 2020
7
Gastric neuroendocrine tumor as a rare type of neoplasm in a kidney transplant recipient. 61
32491303 2020
8
Gastric neuroendocrine tumor: A practical literature review. 61
32879663 2020
9
Gastric Neuroendocrine Tumor Presenting as a Mucinous Appearing Cystic Lesion. 61
32675588 2020
10
Trends of incidence and prognosis of gastric neuroendocrine neoplasms: a study based on SEER and our multicenter research. 61
32026156 2020
11
A Very Unusual Pattern of Intraperitoneal and Extraperitoneal Heterotropic Splenic Tissue-Mimicking Metastases Identified on 68Ga-DOTA-NOC Positron Emission Tomography/Computed Tomography and 99mTc Heat-denatured Erythrocyte Study. 61
33082689 2020
12
Coexisting Somatostatin Receptor Expressing Gastric Neuroendocrine Tumor Primary and Lymph Nodal Tuberculosis on 68Ga-DOTANOC Positron Emission Tomography/Computed Tomography. 61
33082684 2020
13
Marital status, an independent predictor for survival of gastric neuroendocrine neoplasm patients: a SEER database analysis. 61
32703291 2020
14
[Clinical features and prognostic factors of primary gastric neuroendocrine neoplasms]. 61
32209196 2020
15
Inflammatory Myofibroblastic Tumor: Findings on 68Ga-DOTA-NOC Positron-emission Tomography-Computed Tomography. 61
32351276 2020
16
Response and relapse rates after treatment with long-acting somatostatin analogs in multifocal or recurrent type-1 gastric carcinoids: A systematic review and meta-analysis. 61
32213066 2020
17
[Retrospect of 2019: focus on the research progress of gastric neoplasm]. 61
31958924 2020
18
Gastric neuroendocrine tumor with Helicobacter pylori-associated chronic gastritis. 61
32980709 2020
19
The Altered Metabolic Molecular Signatures Contribute to the RAD001 Resistance in Gastric Neuroendocrine Tumor. 61
32373532 2020
20
Pathologic Complete Response After Neoadjuvant Chemoradiation in a Patient with Gastric Neuroendocrine Cancer. 61
31565618 2019
21
Type 1 Gastric Neuroendocrine Tumor Found on Endoscopic Polypectomy. 61
31106093 2019
22
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. 61
30531243 2019
23
[Endoscopic treatment for gastric carcinoid tumor in a patient with type A gastritis complicated with autoimmune polyendocrine syndrome: a case report]. 61
31406070 2019
24
Factors related to gastric neuroendocrine tumors. 61
29705524 2019
25
Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis. 61
30740042 2019
26
[A 3mm Gastric Neuroendocrine Tumor That Metastasized to a Lymph Node]. 61
30692371 2018
27
A Case of Gastric Neuroendocrine Neoplasm with Mixed Grade: a Distinct Type of "High"-grade Well-Differentiated Neuroendocrine Neoplasm. 61
29675587 2018
28
Systemic sclerosis and malignancy. 61
29673080 2018
29
[Research progress of the clinically uncommon gastric carcinoma]. 61
29492923 2018
30
Gastric neuroendocrine tumor arising from heterotopic pancreas. 61
29218566 2018
31
Case Report of a Small Gastric Neuroendocrine Tumor in a Deep Layer of Submucosa With Diagnosis by Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Treatment With Laparoscopic and Endoscopic Cooperative Surgery. 61
29371789 2018
32
Huge recurrent gastric neuroendocrine tumor: a second-line chemotherapeutic dilemma. 61
29515980 2018
33
Gastric neuroendocrine neoplasm with late liver metastasis. 61
30083348 2018
34
An atypical type I gastric neuroendocrine tumor. 61
28710883 2017
35
A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis. 61
28474257 2017
36
HIGH-RISK GASTRIC PATHOLOGY AND PREVALENT AUTOIMMUNE DISEASES IN PATIENTS WITH PERNICIOUS ANEMIA. 61
29190137 2017
37
[Laparoscopic Total Gastrectomy(LTG)in Patient with Multiple Gastric Neuroendocrine Tumor Related to Multiple Endocrine Neoplasia Type 1 - Two Case Reports]. 61
29394551 2017
38
Gastric neuroendocrine tumor mimicking early gastric cancer. 61
28478029 2017
39
GASTRIC NEUROENDOCRINE TUMOR: REVIEW AND UPDATE. 61
29257854 2017
40
Gastric neuroendocrine tumor with hypergastrinemia following type B chronic atrophic gastritis: a case report. 61
28163290 2017
41
[Subtype classification and clinicopathological characteristics of gastric neuroendocrine neoplasms: an analysis of 241 cases]. 61
27928793 2016
42
Pedunculated gastric neuroendocrine tumor: a case report. 61
27853738 2016
43
[Gastric neuroendocrine tumor with G2 and G3 components: report of a case]. 61
27821238 2016
44
Type 3 gastric neuroendocrine tumor with unique endoscopic features. 61
27476464 2016
45
Synchronous Peripancreatic Lymph Node Gastrinoma and Gastric Neuroendocrine Tumor Type 2. 61
27209642 2016
46
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies. 61
27491072 2016
47
Comparison of the prognostic values of the 2010 WHO classification, AJCC 7th edition, and ENETS classification of gastric neuroendocrine tumors. 61
27472674 2016
48
Gastric neuroendocrine tumor presenting with gastrointestinal bleeding. 61
26838499 2016
49
Gastric neuroendocrine tumor (NET): report of one case. 61
28138650 2016
50
Gastric neuroendocrine neoplasm with liver metastases: a case report. 61
28138622 2016

Variations for Gastric Neuroendocrine Neoplasm

Expression for Gastric Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Gastric Neuroendocrine Neoplasm.

Pathways for Gastric Neuroendocrine Neoplasm

GO Terms for Gastric Neuroendocrine Neoplasm

Sources for Gastric Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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