Gastric Papillary Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Gastric Papillary Adenocarcinoma

MalaCards integrated aliases for Gastric Papillary Adenocarcinoma:

Name: Gastric Papillary Adenocarcinoma ¹² ¹⁵ ¹⁷ ⁷⁴

Papillary Adenocarcinoma of Stomach ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5593

NCIt ⁵¹ C5472

EFO ¹⁷ EFO_1000276

UMLS ⁷⁴ C1333785

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Summaries for Gastric Papillary Adenocarcinoma

Disease Ontology : ¹² A papillary adenocarcinoma that is located in the stomach.

MalaCards based summary : Gastric Papillary Adenocarcinoma, also known as papillary adenocarcinoma of stomach, is related to papillary adenocarcinoma and gastric adenocarcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Papillary Adenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Direct p53 effectors and MAPK Pathway. Affiliated tissues include the stomach.

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Related Diseases for Gastric Papillary Adenocarcinoma

Diseases related to Gastric Papillary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)

#	Related Disease	Score	Top Affiliating Genes
1	papillary adenocarcinoma	30.1	ERBB2 TP53
2	gastric adenocarcinoma	29.7	AFP ERBB2 TP53
3	nonseminomatous germ cell tumor	10.2	AFP ERBB2
4	pleomorphic adenoma	10.2	ERBB2 TP53
5	pleomorphic adenoma carcinoma	10.2	ERBB2 TP53
6	non-proliferative fibrocystic change of the breast	10.2	ERBB2 TP53
7	uterine corpus serous adenocarcinoma	10.2	ERBB2 TP53
8	breast squamous cell carcinoma	10.2	ERBB2 TP53
9	uterine body mixed cancer	10.2	ERBB2 TP53
10	glioma susceptibility 1	10.2	ERBB2 TP53
11	microglandular adenosis	10.1	ERBB2 TP53
12	esophagus adenocarcinoma	10.1	ERBB2 TP53
13	breast benign neoplasm	10.1	ERBB2 TP53
14	thoracic benign neoplasm	10.1	ERBB2 TP53
15	uterine corpus cancer	10.1	ERBB2 TP53
16	granulosa cell tumor of the ovary	10.1	ERBB2 TP53
17	hidradenocarcinoma	10.1	ERBB2 TP53
18	primary peritoneal carcinoma	10.1	ERBB2 TP53
19	tubular adenocarcinoma	10.1	AFP ERBB2
20	tonsil cancer	10.1	ERBB2 TP53
21	pre-malignant neoplasm	10.1	ERBB2 TP53
22	fallopian tube carcinoma	10.1	ERBB2 TP53
23	ovary adenocarcinoma	10.1	ERBB2 TP53
24	barrett's adenocarcinoma	10.1	ERBB2 TP53
25	in situ carcinoma	10.1	ERBB2 TP53
26	scrotal carcinoma	10.1	AFP TP53
27	breast carcinoma in situ	10.1	ERBB2 TP53
28	malignant teratoma	10.1	AFP TP53
29	ovarian cancer 1	10.1	ERBB2 TP53
30	teratoma	10.1	AFP TP53
31	malignant ovarian surface epithelial-stromal neoplasm	10.1	ERBB2 TP53
32	mature teratoma	10.1	AFP TP53
33	ovary epithelial cancer	10.1	ERBB2 TP53
34	esophageal disease	10.1	ERBB2 TP53
35	female breast cancer	10.1	ERBB2 TP53
36	serous cystadenocarcinoma	10.1	ERBB2 TP53
37	cystadenocarcinoma	10.1	ERBB2 TP53
38	acinar cell carcinoma	10.1	AFP TP53
39	cervical adenocarcinoma	10.1	ERBB2 TP53
40	estrogen-receptor positive breast cancer	10.1	ERBB2 TP53
41	sweat gland cancer	10.1	ERBB2 TP53
42	germ cell and embryonal cancer	10.1	AFP TP53
43	sporadic breast cancer	10.1	ERBB2 TP53
44	bile duct adenocarcinoma	10.1	AFP TP53
45	bladder disease	10.1	ERBB2 TP53
46	ductal carcinoma in situ	10.1	ERBB2 TP53
47	carcinosarcoma	10.1	ERBB2 TP53
48	ovarian serous cystadenocarcinoma	10.1	ERBB2 TP53
49	stomach disease	10.1	ERBB2 TP53
50	female reproductive system disease	10.1	ERBB2 TP53

Graphical network of the top 20 diseases related to Gastric Papillary Adenocarcinoma:

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Symptoms & Phenotypes for Gastric Papillary Adenocarcinoma

UMLS symptoms related to Gastric Papillary Adenocarcinoma:

abdominal pain, dyspepsia

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Drugs & Therapeutics for Gastric Papillary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Gastric Papillary Adenocarcinoma

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Genetic Tests for Gastric Papillary Adenocarcinoma

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Anatomical Context for Gastric Papillary Adenocarcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gastric Papillary Adenocarcinoma:

²⁰

The Stomach

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Publications for Gastric Papillary Adenocarcinoma

Articles related to Gastric Papillary Adenocarcinoma:

#	Title	Authors	Year
1	Clinicopathological and molecular stability and methylation analyses of gastric papillary adenocarcinoma. ( 28830689 )	Uesugi N....Matsumoto T.	2017

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Genes for Gastric Papillary Adenocarcinoma

Genes related to Gastric Papillary Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	19.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TP53	Tumor Protein P53	Protein Coding	16.69	GeneCards inferred via : Publications (show sections)
3	SIL1	SIL1 Nucleotide Exchange Factor	Protein Coding	15.04	DISEASES inferred ¹⁵
4	PCSK9	Proprotein Convertase Subtilisin/Kexin Type 9	Protein Coding	14.75	DISEASES inferred ¹⁵
5	AFP	Alpha Fetoprotein	Protein Coding	13.38	DISEASES inferred ¹⁵

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Variations for Gastric Papillary Adenocarcinoma

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Expression for Gastric Papillary Adenocarcinoma

Search GEO for disease gene expression data for Gastric Papillary Adenocarcinoma.

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Pathways for Gastric Papillary Adenocarcinoma

Pathways related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Direct p53 effectors ¹	11.55	AFP TP53
2	MAPK Pathway ⁷³ Show member pathways Toll-like Receptor Pathway ⁷³	11.5	ERBB2 TP53
3	DNA Damage Response (only ATM dependent) ¹	11.43	ERBB2 TP53
4	Glucocorticoid receptor regulatory network ¹	11.24	AFP TP53
5	Bladder cancer ³⁸ ¹	11.12	ERBB2 TP53
6	Platinum drug resistance ³⁸	11.02	ERBB2 TP53
7	Pathways Affected in Adenoid Cystic Carcinoma ¹	10.78	ERBB2 TP53
8	Central carbon metabolism in cancer ³⁸	10.44	ERBB2 TP53

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GO Terms for Gastric Papillary Adenocarcinoma

Cellular components related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	8.8	AFP PCSK9 SIL1

Molecular functions related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphatase binding	GO:0019903	8.96	ERBB2 TP53
2	protein self-association	GO:0043621	8.62	PCSK9 TP53

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Sources for Gastric Papillary Adenocarcinoma

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