Gastric Papillary Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Gastric Papillary Adenocarcinoma

MalaCards integrated aliases for Gastric Papillary Adenocarcinoma:

Name: Gastric Papillary Adenocarcinoma ¹² ¹⁵ ¹⁷ ⁷⁰

Papillary Adenocarcinoma of Stomach ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5593

NCIt ⁵⁰ C5472

EFO ¹⁷ EFO_1000276

UMLS ⁷⁰ C1333785

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Summaries for Gastric Papillary Adenocarcinoma

Disease Ontology : ¹² A papillary adenocarcinoma that is located in the stomach.

MalaCards based summary : Gastric Papillary Adenocarcinoma, also known as papillary adenocarcinoma of stomach, is related to microinvasive gastric cancer and papillary adenocarcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Papillary Adenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and DNA Damage Response (only ATM dependent). Affiliated tissues include stomach, breast and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Gastric Papillary Adenocarcinoma

Diseases related to Gastric Papillary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)

#	Related Disease	Score	Top Affiliating Genes
1	microinvasive gastric cancer	30.2	TP53 ERBB2
2	papillary adenocarcinoma	30.1	TP53 ERBB2
3	gastric tubular adenocarcinoma	29.8	ENAH CTSE
4	apocrine adenosis of breast	10.1	TP53 ERBB2
5	breast squamous cell carcinoma	10.1	TP53 ERBB2
6	parotid gland cancer	10.1	TP53 ERBB2
7	comedo carcinoma	10.1	TP53 ERBB2
8	breast sarcoma	10.1	TP53 ERBB2
9	breast malignant phyllodes tumor	10.1	TP53 ERBB2
10	pleomorphic adenoma carcinoma	10.1	TP53 ERBB2
11	pleomorphic adenoma	10.1	TP53 ERBB2
12	esophageal adenosquamous carcinoma	10.1	TP53 ERBB2
13	localized osteosarcoma	10.1	TP53 ERBB2
14	ovarian carcinosarcoma	10.1	TP53 ERBB2
15	carcinosarcoma	10.1	TP53 ERBB2
16	primary peritoneal carcinoma	10.1	TP53 ERBB2
17	granulosa cell tumor of the ovary	10.1	TP53 ERBB2
18	synchronous bilateral breast carcinoma	10.1	TP53 ERBB2
19	large intestine adenocarcinoma	10.1	TP53 ERBB2
20	microglandular adenosis	10.1	TP53 ERBB2
21	vulvar disease	10.1	TP53 ERBB2
22	endometrial serous adenocarcinoma	10.1	TP53 ERBB2
23	hypertrophy of breast	10.1	TP53 ERBB2
24	female reproductive endometrioid cancer	10.1	TP53 ERBB2
25	mature teratoma	10.1	TP53 ERBB2
26	adenosarcoma	10.1	TP53 ERBB2
27	uterine body mixed cancer	10.1	TP53 ERBB2
28	sebaceous adenocarcinoma	10.1	TP53 ERBB2
29	endocervical carcinoma	10.1	TP53 ERBB2
30	lobular neoplasia	10.1	TP53 ERBB2
31	sweat gland cancer	10.1	TP53 ERBB2
32	sweat gland disease	10.1	TP53 ERBB2
33	thoracic benign neoplasm	10.1	TP53 ERBB2
34	breast benign neoplasm	10.1	TP53 ERBB2
35	mixed cell type cancer	10.1	TP53 ERBB2
36	gallbladder adenocarcinoma	10.1	TP53 ERBB2
37	short syndrome	10.1	TP53 ERBB2
38	barrett's adenocarcinoma	10.1	TP53 ERBB2
39	esophagus adenocarcinoma	10.1	TP53 ERBB2
40	rectum adenocarcinoma	10.1	TP53 ERBB2
41	tonsil cancer	10.1	TP53 ERBB2
42	ovarian cystadenocarcinoma	10.1	TP53 ERBB2
43	cystadenocarcinoma	10.1	TP53 ERBB2
44	vulva cancer	10.1	TP53 ERBB2
45	endocervical adenocarcinoma	10.1	TP53 ERBB2
46	cervical adenocarcinoma	10.1	TP53 ERBB2
47	uterine corpus cancer	10.1	TP53 ERBB2
48	childhood medulloblastoma	10.1	TP53 ERBB2
49	breast fibroadenoma	10.1	TP53 ERBB2
50	oropharynx cancer	10.1	TP53 ERBB2

Graphical network of the top 20 diseases related to Gastric Papillary Adenocarcinoma:

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Symptoms & Phenotypes for Gastric Papillary Adenocarcinoma

UMLS symptoms related to Gastric Papillary Adenocarcinoma:

abdominal pain; dyspepsia

GenomeRNAi Phenotypes related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-104	9.44	ENAH
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-117	9.44	ENAH
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-119	9.44	ENAH
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-126	9.44	CTSE
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-144	9.44	ENAH
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-145	9.44	CTSE
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-163	9.44	ENAH
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-184	9.44	ENAH
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-189	9.44	ENAH
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-25	9.44	CTSE ENAH
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-26	9.44	ENAH
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-80	9.44	ENAH

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Drugs & Therapeutics for Gastric Papillary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Gastric Papillary Adenocarcinoma

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Genetic Tests for Gastric Papillary Adenocarcinoma

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Anatomical Context for Gastric Papillary Adenocarcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gastric Papillary Adenocarcinoma:

¹⁹

Stomach

MalaCards organs/tissues related to Gastric Papillary Adenocarcinoma:

⁴⁰

Breast, Ovary, Salivary Gland, Small Intestine, Thyroid, Skin, Cervix

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Publications for Gastric Papillary Adenocarcinoma

Articles related to Gastric Papillary Adenocarcinoma:

#	Title	Authors	PMID	Year
1	Endoscopic submucosal dissection of papillary adenocarcinoma of stomach; protocol for a systematic review and meta-analysis. ⁶¹	Bang CS...Baik GH	30593208	2018
2	Clinicopathological and molecular stability and methylation analyses of gastric papillary adenocarcinoma. ⁶¹	Uesugi N...Matsumoto T	28830689	2017
3	Clinical and prognostic characteristics of papillary clear carcinoma of stomach. ⁶¹	Uefuji K...Tamakuma S	8845606	1996
4	Localization and alteration of mono-, di-, and trifucosyl alpha 1----3 type 2 chain structures during human embryogenesis and in human cancer. ⁶¹	Fukushi Y...Shepard T	6147386	1984

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Genes for Gastric Papillary Adenocarcinoma

Genes related to Gastric Papillary Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	10.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	ARFIP2	ADP Ribosylation Factor Interacting Protein 2	Protein Coding	6.65	DISEASES inferred ¹⁵
3	TP53	Tumor Protein P53	Protein Coding	6.61	GeneCards inferred via : Publications (show sections)
4	ENAH	ENAH Actin Regulator	Protein Coding	6.33	DISEASES inferred ¹⁵
5	CTSE	Cathepsin E	Protein Coding	6.01	DISEASES inferred ¹⁵

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Variations for Gastric Papillary Adenocarcinoma

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Expression for Gastric Papillary Adenocarcinoma

Search GEO for disease gene expression data for Gastric Papillary Adenocarcinoma.

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Pathways for Gastric Papillary Adenocarcinoma

Pathways related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	12.1	TP53 ERBB2 ENAH CTSE
2	DNA Damage Response (only ATM dependent) ¹	11.46	TP53 ERBB2
3	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	11.43	ERBB2 ENAH ARFIP2
4	Platinum drug resistance ³⁶	11.23	TP53 ERBB2
5	Bladder cancer ³⁶ ¹	11.18	TP53 ERBB2
6	Central carbon metabolism in cancer ³⁶	11.1	TP53 ERBB2
7	Pathways Affected in Adenoid Cystic Carcinoma ¹	10.98	TP53 ERBB2

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GO Terms for Gastric Papillary Adenocarcinoma

Molecular functions related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphatase binding	GO:0019903	8.96	TP53 ERBB2
2	identical protein binding	GO:0042802	8.92	TP53 ERBB2 CTSE ARFIP2

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Sources for Gastric Papillary Adenocarcinoma

¹ BioSystems

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²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

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²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

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³⁵ IUPHAR

³⁶ KEGG

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³⁸ LncRNADisease

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⁴⁰ MalaCards

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⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia