MCID: GST032
MIFTS: 27

Gastric Papillary Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Papillary Adenocarcinoma

MalaCards integrated aliases for Gastric Papillary Adenocarcinoma:

Name: Gastric Papillary Adenocarcinoma 12 15 17 70
Papillary Adenocarcinoma of Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5593
NCIt 50 C5472
UMLS 70 C1333785

Summaries for Gastric Papillary Adenocarcinoma

Disease Ontology : 12 A papillary adenocarcinoma that is located in the stomach.

MalaCards based summary : Gastric Papillary Adenocarcinoma, also known as papillary adenocarcinoma of stomach, is related to microinvasive gastric cancer and papillary adenocarcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Papillary Adenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and DNA Damage Response (only ATM dependent). Affiliated tissues include stomach, breast and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Gastric Papillary Adenocarcinoma

Diseases related to Gastric Papillary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 microinvasive gastric cancer 30.2 TP53 ERBB2
2 papillary adenocarcinoma 30.1 TP53 ERBB2
3 gastric tubular adenocarcinoma 29.8 ENAH CTSE
4 apocrine adenosis of breast 10.1 TP53 ERBB2
5 breast squamous cell carcinoma 10.1 TP53 ERBB2
6 parotid gland cancer 10.1 TP53 ERBB2
7 comedo carcinoma 10.1 TP53 ERBB2
8 breast sarcoma 10.1 TP53 ERBB2
9 breast malignant phyllodes tumor 10.1 TP53 ERBB2
10 pleomorphic adenoma carcinoma 10.1 TP53 ERBB2
11 pleomorphic adenoma 10.1 TP53 ERBB2
12 esophageal adenosquamous carcinoma 10.1 TP53 ERBB2
13 localized osteosarcoma 10.1 TP53 ERBB2
14 ovarian carcinosarcoma 10.1 TP53 ERBB2
15 carcinosarcoma 10.1 TP53 ERBB2
16 primary peritoneal carcinoma 10.1 TP53 ERBB2
17 granulosa cell tumor of the ovary 10.1 TP53 ERBB2
18 synchronous bilateral breast carcinoma 10.1 TP53 ERBB2
19 large intestine adenocarcinoma 10.1 TP53 ERBB2
20 microglandular adenosis 10.1 TP53 ERBB2
21 vulvar disease 10.1 TP53 ERBB2
22 endometrial serous adenocarcinoma 10.1 TP53 ERBB2
23 hypertrophy of breast 10.1 TP53 ERBB2
24 female reproductive endometrioid cancer 10.1 TP53 ERBB2
25 mature teratoma 10.1 TP53 ERBB2
26 adenosarcoma 10.1 TP53 ERBB2
27 uterine body mixed cancer 10.1 TP53 ERBB2
28 sebaceous adenocarcinoma 10.1 TP53 ERBB2
29 endocervical carcinoma 10.1 TP53 ERBB2
30 lobular neoplasia 10.1 TP53 ERBB2
31 sweat gland cancer 10.1 TP53 ERBB2
32 sweat gland disease 10.1 TP53 ERBB2
33 thoracic benign neoplasm 10.1 TP53 ERBB2
34 breast benign neoplasm 10.1 TP53 ERBB2
35 mixed cell type cancer 10.1 TP53 ERBB2
36 gallbladder adenocarcinoma 10.1 TP53 ERBB2
37 short syndrome 10.1 TP53 ERBB2
38 barrett's adenocarcinoma 10.1 TP53 ERBB2
39 esophagus adenocarcinoma 10.1 TP53 ERBB2
40 rectum adenocarcinoma 10.1 TP53 ERBB2
41 tonsil cancer 10.1 TP53 ERBB2
42 ovarian cystadenocarcinoma 10.1 TP53 ERBB2
43 cystadenocarcinoma 10.1 TP53 ERBB2
44 vulva cancer 10.1 TP53 ERBB2
45 endocervical adenocarcinoma 10.1 TP53 ERBB2
46 cervical adenocarcinoma 10.1 TP53 ERBB2
47 uterine corpus cancer 10.1 TP53 ERBB2
48 childhood medulloblastoma 10.1 TP53 ERBB2
49 breast fibroadenoma 10.1 TP53 ERBB2
50 oropharynx cancer 10.1 TP53 ERBB2

Graphical network of the top 20 diseases related to Gastric Papillary Adenocarcinoma:



Diseases related to Gastric Papillary Adenocarcinoma

Symptoms & Phenotypes for Gastric Papillary Adenocarcinoma

UMLS symptoms related to Gastric Papillary Adenocarcinoma:


abdominal pain; dyspepsia

GenomeRNAi Phenotypes related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.44 ENAH
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.44 ENAH
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.44 ENAH
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.44 CTSE
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.44 ENAH
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.44 CTSE
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-163 9.44 ENAH
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.44 ENAH
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-189 9.44 ENAH
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 9.44 CTSE ENAH
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.44 ENAH
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-80 9.44 ENAH

Drugs & Therapeutics for Gastric Papillary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Gastric Papillary Adenocarcinoma

Genetic Tests for Gastric Papillary Adenocarcinoma

Anatomical Context for Gastric Papillary Adenocarcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gastric Papillary Adenocarcinoma:

19
Stomach

MalaCards organs/tissues related to Gastric Papillary Adenocarcinoma:

40
Breast, Ovary, Salivary Gland, Small Intestine, Thyroid, Skin, Cervix

Publications for Gastric Papillary Adenocarcinoma

Articles related to Gastric Papillary Adenocarcinoma:

# Title Authors PMID Year
1
Endoscopic submucosal dissection of papillary adenocarcinoma of stomach; protocol for a systematic review and meta-analysis. 61
30593208 2018
2
Clinicopathological and molecular stability and methylation analyses of gastric papillary adenocarcinoma. 61
28830689 2017
3
Clinical and prognostic characteristics of papillary clear carcinoma of stomach. 61
8845606 1996
4
Localization and alteration of mono-, di-, and trifucosyl alpha 1----3 type 2 chain structures during human embryogenesis and in human cancer. 61
6147386 1984

Variations for Gastric Papillary Adenocarcinoma

Expression for Gastric Papillary Adenocarcinoma

Search GEO for disease gene expression data for Gastric Papillary Adenocarcinoma.

Pathways for Gastric Papillary Adenocarcinoma

Pathways related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 TP53 ERBB2 ENAH CTSE
2 11.46 TP53 ERBB2
3
Show member pathways
11.43 ERBB2 ENAH ARFIP2
4 11.23 TP53 ERBB2
5 11.18 TP53 ERBB2
6 11.1 TP53 ERBB2
7 10.98 TP53 ERBB2

GO Terms for Gastric Papillary Adenocarcinoma

Molecular functions related to Gastric Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 8.96 TP53 ERBB2
2 identical protein binding GO:0042802 8.92 TP53 ERBB2 CTSE ARFIP2

Sources for Gastric Papillary Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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