MCID: GST016
MIFTS: 26

Gastric Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Gastric Signet Ring Cell Adenocarcinoma:

Name: Gastric Signet Ring Cell Adenocarcinoma 12 15
Signet Ring Cell Gastric Adenocarcinoma 17 70
Signet Ring Cell Adenocarcinoma of the Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8025
NCIt 50 C5250
UMLS 70 C1335965

Summaries for Gastric Signet Ring Cell Adenocarcinoma

MalaCards based summary : Gastric Signet Ring Cell Adenocarcinoma, also known as signet ring cell gastric adenocarcinoma, is related to signet ring cell adenocarcinoma and linitis plastica, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Signet Ring Cell Adenocarcinoma is PIP (Prolactin Induced Protein). The drugs Cisplatin and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include breast, appendix and colon.

Related Diseases for Gastric Signet Ring Cell Adenocarcinoma

Diseases related to Gastric Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 30.7 PIP KRT7 CDX2
2 linitis plastica 30.1 PIP KRT7 CDX2
3 intestinal obstruction 29.9 KRT7 CDX2
4 gastric adenocarcinoma 10.5
5 adenocarcinoma 10.4
6 autoimmune disease 10.2
7 pernicious anemia 10.2
8 sarcoidosis 1 10.2
9 adrenocortical carcinoma, hereditary 10.2
10 ascites, chylous 10.2
11 lung cancer 10.2
12 rothmund-thomson syndrome, type 2 10.2
13 deficiency anemia 10.2
14 adrenal cortical carcinoma 10.2
15 thrombosis 10.2
16 hereditary lymphedema i 10.2
17 disseminated intravascular coagulation 10.2
18 paracoccidioidomycosis 10.2
19 iritis 10.2
20 angioedema 10.2
21 thrombocytopenia 10.2
22 squamous cell carcinoma 10.2
23 kidney cancer 10.2
24 antiphospholipid syndrome 10.2
25 adrenal cortical adenocarcinoma 10.2
26 gastritis 10.2
27 hemolytic anemia 10.2
28 back pain 10.2
29 gastric linitis plastica 10.2
30 ceruminoma 10.0 PIP KRT7
31 malignant acrospiroma 10.0 PIP KRT7
32 oncocytic breast carcinoma 10.0 PIP KRT7
33 ceruminous adenocarcinoma 10.0 PIP KRT7
34 cutaneous mucoepidermoid carcinoma 10.0 PIP KRT7
35 vulval paget's disease 10.0 PIP KRT7
36 eccrine adenocarcinoma 10.0 PIP KRT7
37 vulvar apocrine adenocarcinoma 9.9 PIP KRT7
38 apocrine adenocarcinoma 9.9 PIP KRT7
39 eyelid carcinoma 9.9 PIP KRT7
40 malignant syringoma 9.9 PIP KRT7
41 breast mucinous carcinoma 9.9 PIP KRT7
42 erysipeloid 9.9 PIP KRT7
43 clear cell hidradenoma 9.9 PIP KRT7
44 hidradenoma 9.9 PIP KRT7
45 eccrine sweat gland cancer 9.9 PIP KRT7
46 sweat gland cancer 9.9 PIP KRT7
47 hidrocystoma 9.9 PIP KRT7
48 eccrine papillary adenocarcinoma 9.9 PIP KRT7
49 papillary adenocarcinoma 9.9 PIP KRT7
50 eccrine acrospiroma 9.9 PIP KRT7

Graphical network of the top 20 diseases related to Gastric Signet Ring Cell Adenocarcinoma:



Diseases related to Gastric Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Gastric Signet Ring Cell Adenocarcinoma

UMLS symptoms related to Gastric Signet Ring Cell Adenocarcinoma:


abdominal pain; dyspepsia

Drugs & Therapeutics for Gastric Signet Ring Cell Adenocarcinoma

Drugs for Gastric Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved 15663-27-1 84093 441203 2767
2
Epirubicin Approved 56420-45-2 41867
3
Fluorouracil Approved 51-21-8 3385

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Randomized Controlled Trial to Evaluate the Strategy of Primary Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma (ADCI002 Study) Recruiting NCT01717924

Search NIH Clinical Center for Gastric Signet Ring Cell Adenocarcinoma

Genetic Tests for Gastric Signet Ring Cell Adenocarcinoma

Anatomical Context for Gastric Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Gastric Signet Ring Cell Adenocarcinoma:

40
Breast, Appendix, Colon, Kidney, Lung, Ovary, Bone Marrow

Publications for Gastric Signet Ring Cell Adenocarcinoma

Articles related to Gastric Signet Ring Cell Adenocarcinoma:

(show all 50)
# Title Authors PMID Year
1
Should Signet Ring Cell Histology Alter the Treatment Approach for Clinical Stage I Gastric Cancer? 61
32524459 2021
2
Rare Presentation of a Rare Disease: Signet-Ring Cell Gastric Adenocarcinoma in Rothmund-Thomson Syndrome. 61
33409099 2020
3
ASO Author Reflections: A Surgery-First Approach for Patients With Clinical Stage 1 Signet Ring Cell Gastric Adenocarcinoma. 61
32533396 2020
4
Metastatic Gastric Signet Ring Cell Adenocarcinoma Masquerading as Low Back Pain. 61
33282574 2020
5
Dural Metastasis without Subdural Hematoma or Subdural Fluid Collection in a Patient with Signet Ring Cell Gastric Adenocarcinoma. 61
33010147 2020
6
Clinicopathological Evaluation of Gastric Signet Ring Cell Carcinoma: Our Experience. 61
33511069 2020
7
Metastatic Gastric Signet Ring Cell Adenocarcinoma Presenting With Colonic Stenosis. 61
32642336 2020
8
Metastasis From Gastric Signet Ring Cell Adenocarcinoma Presenting as a Rectosigmoid Stricture: A Rare Case. 61
32670689 2020
9
Massive gastric distension due to signet-ring cell gastric adenocarcinoma. 61
32754546 2020
10
Paracoccidiodomycosis lung reactivation in a patient with signet-ring cell gastric adenocarcinoma after chemotherapy: Case report. 61
32420028 2020
11
A Case of Antiphospholipid Syndrome Following Gastric Signet Ring Cell Adenocarcinoma. 61
31953377 2020
12
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma. 61
30333909 2018
13
An elderly man with gastric cancer, Saint's triad and Heyde's syndrome. 61
30540734 2018
14
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. 61
29801472 2018
15
Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma. 61
28740840 2017
16
Signet Cell in the Brain: A Case Report of Leptomeningeal Carcinomatosis as the Presenting Feature of Gastric Signet Cell Cancer. 61
28405535 2017
17
Radiographic and endoscopic regression of metastatic gastric cancer to the colon in the setting of 5-aminosalicylic acid use. 61
28078130 2016
18
An Unusual Recurrence of Signet Ring Cell Gastric Adenocarcinoma Treated by Right Hemicolectomy, Pancreaticoduodenectomy, and IVC Resection: Controversies and Dilemmas of Following Standard Treatment Pathways. 61
26848413 2015
19
Pulmonary lymphangitic carcinomatosis from metastatic gastric adenocarcinoma: case report. 61
25938528 2015
20
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. 61
25436133 2014
21
Osteoblastic metastasis from signet ring cell gastric cancer in a young male. 61
25910343 2014
22
[Gastric signet ring cell adenocarcinoma: A distinct entity]. 61
24440764 2014
23
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. 61
25524189 2014
24
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. 61
23313257 2013
25
Chylous ascites due to signet ring cell gastric adenocarcinoma. 61
23238204 2012
26
Diffuse Signet-Ring Cell Gastric Adenocarcinoma "Linitis Plastica" and Pernicious Anemia: a Rare Association. 61
22760711 2012
27
Signet-ring cell gastric adenocarcinoma metastasizing into a primary cutaneous squamous cell carcinoma of the scalp. 61
22616597 2012
28
Mid-abdominal bulging after breast reconstruction due to peritoneal carcinomatosis of advanced gastric adenocarcinoma. 61
21764654 2011
29
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. 61
22005144 2011
30
[Coexistence of multifocal gastric adenocarcinoma with signet-ring cell morphology and a gastrointestinal stromal tumour in a stomach with hp-associated gastritis]. 61
21298606 2011
31
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. 61
20739130 2010
32
Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation. 61
20624523 2010
33
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. 61
20425670 2010
34
Colonic anastomosis and colonic polyp mucosal metastasis of signet ring cell gastric adenocarcinoma. 61
20231131 2010
35
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. 61
18263634 2008
36
A rare case of signet ring cell gastric adenocarcinoma. 61
19292116 2007
37
Metastatic signet ring gastric adenocarcinoma presenting with microangiopathic hemolytic anemia. 61
17986749 2007
38
'Signet-ring' cell gastric adenocarcinoma metastatic to a neurogenous hyperplasia of the appendix. 61
17394504 2007
39
[Intestinal linitis plastica: late metastasis from gastric signet ring cell adenocarcinoma]. 61
16956554 2006
40
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. 61
16831674 2006
41
Signet ring cell carcinoma in the prostate. 61
15074731 2004
42
Epididymal metastasis from gastric signet ring cell adenocarcinoma. 61
12010596 2002
43
Gastric signet ring cell adenocarcinoma metastatic to the iris. 61
11239875 2001
44
[Bladder metastasis of signet-ring cell adenocarcinoma from the stomach]. 61
11196392 2000
45
Gastric adenocarcinoma and low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. 61
9114837 1997
46
Acquired deficiency in C1-inhibitor associated with signet ring cell gastric adenocarcinoma: a probable connection of antitumor-associated antibodies, hemolytic anemia, and complement turnover. 61
7822653 1995
47
Polyvinylpyrrolidone storage disease: a source of error in the diagnosis of signet ring cell gastric adenocarcinoma. 61
8191638 1994
48
Metastases of a gastric adenocarcinoma presenting as colonic polyposis. Report of a case. 61
1647292 1991
49
Characterization of a newly established cell line (JR-St) derived from human gastric signet ring cell cancer, producing tumor markers. 61
1848829 1991
50
Progressive blindness caused by metastatic occult signet-ring cell gastric carcinoma. 61
3006649 1986

Variations for Gastric Signet Ring Cell Adenocarcinoma

Expression for Gastric Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Gastric Signet Ring Cell Adenocarcinoma.

Pathways for Gastric Signet Ring Cell Adenocarcinoma

GO Terms for Gastric Signet Ring Cell Adenocarcinoma

Sources for Gastric Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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