MCID: GST016
MIFTS: 40

Gastric Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Gastric Signet Ring Cell Adenocarcinoma:

Name: Gastric Signet Ring Cell Adenocarcinoma 12 15
Signet Ring Cell Adenocarcinoma of the Stomach 12
Signet Ring Cell Gastric Adenocarcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8025
NCIt 50 C5250
UMLS 73 C1335965

Summaries for Gastric Signet Ring Cell Adenocarcinoma

MalaCards based summary : Gastric Signet Ring Cell Adenocarcinoma, also known as signet ring cell adenocarcinoma of the stomach, is related to signet ring cell adenocarcinoma and adenocarcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Signet Ring Cell Adenocarcinoma is UPK2 (Uroplakin 2), and among its related pathways/superpathways are PAK Pathway and Gastric cancer. The drugs Epirubicin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and colon, and related phenotypes are cardiovascular system and cellular

Related Diseases for Gastric Signet Ring Cell Adenocarcinoma

Diseases related to Gastric Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 31.3 CDH1 CDX2
2 adenocarcinoma 10.7
3 embryoma 10.2 CDX2 GATA3
4 cochlear disease 10.2 GATA3 SNAI2
5 sarcomatoid renal cell carcinoma 10.2 CDH1 GATA3
6 spastic paraplegia 25, autosomal recessive 10.2 FGF13 FGF2
7 anal paget's disease 10.2 CDX2 CEACAM5
8 mucinous adenofibroma 10.2 CDX2 CEACAM5
9 anus adenocarcinoma 10.1 CDX2 CEACAM5
10 diffuse glomerulonephritis 10.1 FGF13 FGF2
11 thymus adenocarcinoma 10.1 CDX2 CEACAM5
12 microinvasive gastric cancer 10.1 CDH1 CDX2
13 rectum adenocarcinoma 10.1 CDX2 CEACAM5
14 mucinous ovarian cystadenoma 10.1 CDX2 CEACAM5
15 cystitis cystica 10.1 CDX2 GATA3 UPK2
16 clivus chordoma 10.1 FGF13 FGF2
17 brachydactyly, type b2 10.1 FGF13 FGF2
18 biliary papillomatosis 10.1 CDX2 CEACAM5
19 esophageal adenosquamous carcinoma 10.1 CDH1 CEACAM5
20 thrombosis 10.1
21 gastric diffuse adenocarcinoma 10.1 CDH1 CDX2 UPK2
22 ovarian mucinous neoplasm 10.1 CDX2 CEACAM5
23 cribriform carcinoma 10.1 GATA3 PGR
24 breast adenomyoepithelioma 10.1 CDH1 CEACAM5
25 breast myoepithelial neoplasm 10.1 CDH1 CEACAM5
26 clear cell acanthoma 10.1 CEACAM5 GATA3
27 tonsil cancer 10.1 CDH1 SNAI2
28 infiltrative basal cell carcinoma 10.1 CDH1 CEACAM5
29 luminal breast carcinoma 10.1 GATA3 PGR
30 cecum adenocarcinoma 10.1 CDX2 FGF2
31 chondroid chordoma 10.1 CDH1 CEACAM5
32 brachydactyly, type b1 10.1 FGF13 FGF2
33 inflammatory breast carcinoma 10.1 CDH1 PGR
34 spastic paraplegia 3, autosomal dominant 10.1 CDH1 SNAI1
35 disuse amblyopia 10.1 FGF13 FGF2
36 granulomatous endometritis 10.0 CEACAM5 PGR
37 intracystic papillary adenoma 10.0 CEACAM5 PGR
38 breast mucoepidermoid carcinoma 10.0 CEACAM5 PGR
39 bartholin's duct cyst 10.0 GATA3 PIP
40 adenoid basal cell carcinoma 10.0 CEACAM5 PGR
41 pancreatic serous cystadenoma 10.0 CEACAM5 PGR
42 ecthyma 10.0 FGF2 GATA3
43 colonic disease 10.0 CDH1 CDX2 CEACAM5
44 colorectal adenocarcinoma 10.0 CDH1 CDX2 CEACAM5
45 stomach disease 10.0 CDH1 CDX2 CEACAM5
46 large intestine adenocarcinoma 10.0 CDH1 PIP
47 intestinal disease 10.0 CDH1 CDX2 CEACAM5
48 angiomatous meningioma 10.0 FGF2 PGR
49 bronchiolo-alveolar adenocarcinoma 10.0 CDH1 CDX2
50 intestinal benign neoplasm 10.0 CDX2 CEACAM5

Graphical network of the top 20 diseases related to Gastric Signet Ring Cell Adenocarcinoma:



Diseases related to Gastric Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Gastric Signet Ring Cell Adenocarcinoma

UMLS symptoms related to Gastric Signet Ring Cell Adenocarcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Signet Ring Cell Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 CDH1 CDX2 FGF2 GATA3 HPSE PGR
2 cellular MP:0005384 10.06 CDH1 CDX2 FGF13 FGF2 GATA3 HPSE
3 digestive/alimentary MP:0005381 9.85 CDH1 CDX2 GATA3 PIP SNAI1 SNAI2
4 mortality/aging MP:0010768 9.81 CDH1 CDX2 FGF13 FGF2 GATA3 PGR
5 embryo MP:0005380 9.8 CDH1 CDX2 GATA3 PGR SNAI1 SNAI2
6 endocrine/exocrine gland MP:0005379 9.8 CDH1 CDX2 GATA3 HPSE PGR PIP
7 reproductive system MP:0005389 9.5 CDH1 CDX2 FGF2 GATA3 PGR PIP
8 skeleton MP:0005390 9.17 CDX2 FGF2 GATA3 HPSE PGR SNAI1

Drugs & Therapeutics for Gastric Signet Ring Cell Adenocarcinoma

Drugs for Gastric Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epirubicin Approved Not Applicable 56420-45-2 41867
2
Fluorouracil Approved Not Applicable 51-21-8 3385
3
Cisplatin Approved Not Applicable 15663-27-1 2767 441203 84093

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma Recruiting NCT01717924 Not Applicable

Search NIH Clinical Center for Gastric Signet Ring Cell Adenocarcinoma

Genetic Tests for Gastric Signet Ring Cell Adenocarcinoma

Anatomical Context for Gastric Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Gastric Signet Ring Cell Adenocarcinoma:

41
Bone, Lung, Colon, Ovary, Tonsil, Pancreas, Thymus

Publications for Gastric Signet Ring Cell Adenocarcinoma

Articles related to Gastric Signet Ring Cell Adenocarcinoma:

(show all 12)
# Title Authors Year
1
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. ( 29801472 )
2018
2
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma. ( 30333909 )
2018
3
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
4
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
5
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
6
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
7
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
8
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
9
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
10
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
11
Epididymal metastasis from gastric signet ring cell adenocarcinoma. ( 12010596 )
2002
12
Gastric signet ring cell adenocarcinoma metastatic to the iris. ( 11239875 )
2001

Variations for Gastric Signet Ring Cell Adenocarcinoma

Expression for Gastric Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Gastric Signet Ring Cell Adenocarcinoma.

Pathways for Gastric Signet Ring Cell Adenocarcinoma

GO Terms for Gastric Signet Ring Cell Adenocarcinoma

Biological processes related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.92 CDX2 FGF2 SNAI1 SNAI2 UPK2
2 positive regulation of transcription, DNA-templated GO:0045893 9.72 CDH1 CDX2 FGF2 GATA3 SNAI1
3 positive regulation of protein kinase B signaling GO:0051897 9.69 FGF2 GATA3 HPSE
4 animal organ morphogenesis GO:0009887 9.61 CDX2 FGF2 GATA3
5 epithelial to mesenchymal transition GO:0001837 9.54 SNAI1 SNAI2
6 negative regulation of anoikis GO:2000811 9.49 CEACAM5 SNAI2
7 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 9.48 SNAI1 SNAI2
8 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.46 SNAI1 SNAI2
9 regulation of bicellular tight junction assembly GO:2000810 9.4 SNAI1 SNAI2
10 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.37 SNAI1 SNAI2
11 cartilage morphogenesis GO:0060536 9.26 SNAI1 SNAI2
12 paracrine signaling GO:0038001 9.16 FGF2 PGR
13 negative regulation of vitamin D biosynthetic process GO:0010957 8.96 SNAI1 SNAI2
14 aortic valve morphogenesis GO:0003180 8.8 GATA3 SNAI1 SNAI2

Molecular functions related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.55 CDX2 GATA3 PGR SNAI1 SNAI2
2 protein dimerization activity GO:0046983 9.54 GATA3 HPSE PIP
3 proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001078 9.5 GATA3 SNAI1 SNAI2
4 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 9.43 CDX2 SNAI1 SNAI2
5 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.26 CDX2 GATA3 SNAI1 SNAI2
6 E-box binding GO:0070888 8.8 GATA3 SNAI1 SNAI2

Sources for Gastric Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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