MCID: GST016
MIFTS: 35

Gastric Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Gastric Signet Ring Cell Adenocarcinoma:

Name: Gastric Signet Ring Cell Adenocarcinoma 12 15
Signet Ring Cell Adenocarcinoma of the Stomach 12
Signet Ring Cell Gastric Adenocarcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8025
NCIt 50 C5250
UMLS 73 C1335965

Summaries for Gastric Signet Ring Cell Adenocarcinoma

MalaCards based summary : Gastric Signet Ring Cell Adenocarcinoma, also known as signet ring cell adenocarcinoma of the stomach, is related to signet ring cell adenocarcinoma and anal paget's disease, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Signet Ring Cell Adenocarcinoma is UPK2 (Uroplakin 2), and among its related pathways/superpathways are Gastric cancer and Preimplantation Embryo. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related phenotypes are cellular and cardiovascular system

Related Diseases for Gastric Signet Ring Cell Adenocarcinoma

Diseases related to Gastric Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 31.5 CDH1 CDX2
2 anal paget's disease 10.5 CDX2 CEACAM5
3 anus adenocarcinoma 10.5 CDX2 CEACAM5
4 adenocarcinoma 10.5
5 thymus adenocarcinoma 10.5 CDX2 CEACAM5
6 mucinous ovarian cystadenoma 10.5 CDX2 CEACAM5
7 rectum adenocarcinoma 10.5 CDX2 CEACAM5
8 esophageal adenosquamous carcinoma 10.5 CDH1 CEACAM5
9 biliary papillomatosis 10.4 CDX2 CEACAM5
10 superior mesenteric artery syndrome 10.4 CDX2 CEACAM5
11 ovarian mucinous neoplasm 10.4 CDX2 CEACAM5
12 granulomatous endometritis 10.4 CEACAM5 PGR
13 vulvar syringoma 10.4 ESR1 PGR
14 lung leiomyoma 10.4 ESR1 PGR
15 vestibular gland benign neoplasm 10.4 ESR1 PGR
16 bartholin's gland adenoma 10.4 ESR1 PGR
17 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
18 vulvar benign neoplasm 10.4 ESR1 PGR
19 trigonitis 10.4 ESR1 PGR
20 vulvar leiomyoma 10.4 ESR1 PGR
21 breast mucoepidermoid carcinoma 10.4 CEACAM5 PGR
22 intracystic papillary adenoma 10.4 CEACAM5 PGR
23 predominantly cortical thymoma 10.4 ESR1 PGR
24 breast medullary carcinoma 10.4 ESR1 PGR
25 breast scirrhous carcinoma 10.4 ESR1 PGR
26 progesterone resistance 10.4 ESR1 PGR
27 progesterone-receptor positive breast cancer 10.4 ESR1 PGR
28 cribriform carcinoma 10.4 ESR1 PGR
29 endometrial squamous cell carcinoma 10.4 ESR1 PGR
30 breast adenomyoepithelioma 10.4 CDH1 CEACAM5
31 endometrial mucinous adenocarcinoma 10.4 ESR1 PGR
32 clear cell acanthoma 10.4 CEACAM5 GATA3
33 apocrine adenocarcinoma 10.4 ESR1 PGR
34 gender identity disorder 10.4 ESR1 PGR
35 breast myoepithelial neoplasm 10.4 CDH1 CEACAM5
36 bartholin's gland benign neoplasm 10.4 ESR1 PGR
37 jejunal adenocarcinoma 10.4 CDX2 SMUG1
38 deep angioma 10.4 ESR1 PGR
39 pancreatic serous cystadenoma 10.4 CEACAM5 PGR
40 lobular neoplasia 10.4 CDH1 ESR1
41 synchronous bilateral breast carcinoma 10.4 ESR1 PGR
42 breast adenoid cystic carcinoma 10.4 ESR1 PGR
43 cervical carcinosarcoma 10.4 ESR1 PGR
44 estrogen excess 10.4 ESR1 PGR
45 infiltrative basal cell carcinoma 10.4 CDH1 CEACAM5
46 intramuscular hemangioma 10.4 ESR1 PGR
47 cystitis cystica 10.4 CDX2 GATA3 UPK2
48 glycogen-rich clear cell breast carcinoma 10.3 ESR1 PGR
49 mammographic density 10.3 ESR1 PGR
50 chondroid chordoma 10.3 CDH1 CEACAM5

Graphical network of the top 20 diseases related to Gastric Signet Ring Cell Adenocarcinoma:



Diseases related to Gastric Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Gastric Signet Ring Cell Adenocarcinoma

UMLS symptoms related to Gastric Signet Ring Cell Adenocarcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Signet Ring Cell Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 PIP CDH1 SMUG1 CDX2 ESR1 GATA3
2 cardiovascular system MP:0005385 9.85 PIP CDH1 CDX2 ESR1 GATA3 PGR
3 digestive/alimentary MP:0005381 9.65 PIP CDH1 CDX2 ESR1 GATA3
4 endocrine/exocrine gland MP:0005379 9.63 PIP CDH1 CDX2 ESR1 GATA3 PGR
5 neoplasm MP:0002006 9.35 SMUG1 CDX2 ESR1 PGR CDH1
6 reproductive system MP:0005389 9.1 CDH1 CDX2 ESR1 GATA3 PGR PIP

Drugs & Therapeutics for Gastric Signet Ring Cell Adenocarcinoma

Drugs for Gastric Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Not Applicable 15663-27-1 84093 441203 2767
2
Fluorouracil Approved Not Applicable 51-21-8 3385
3
Epirubicin Approved Not Applicable 56420-45-2 41867

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma Recruiting NCT01717924 Not Applicable

Search NIH Clinical Center for Gastric Signet Ring Cell Adenocarcinoma

Genetic Tests for Gastric Signet Ring Cell Adenocarcinoma

Anatomical Context for Gastric Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Gastric Signet Ring Cell Adenocarcinoma:

41
Bone, Bone Marrow

Publications for Gastric Signet Ring Cell Adenocarcinoma

Articles related to Gastric Signet Ring Cell Adenocarcinoma:

(show all 11)
# Title Authors Year
1
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. ( 29801472 )
2018
2
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
3
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
4
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
5
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
6
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
7
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
8
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
9
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
10
Epididymal metastasis from gastric signet ring cell adenocarcinoma. ( 12010596 )
2002
11
Gastric signet ring cell adenocarcinoma metastatic to the iris. ( 11239875 )
2001

Variations for Gastric Signet Ring Cell Adenocarcinoma

Expression for Gastric Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Gastric Signet Ring Cell Adenocarcinoma.

Pathways for Gastric Signet Ring Cell Adenocarcinoma

Pathways related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CDH1 CDX2 ESR1 PGR
2 10.58 CDH1 CDX2 GATA3

GO Terms for Gastric Signet Ring Cell Adenocarcinoma

Biological processes related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.33 ESR1 GATA3 PGR
2 positive regulation of cell differentiation GO:0045597 9.26 CDX2 GATA3
3 positive regulation of transcription, DNA-templated GO:0045893 9.26 CDH1 CDX2 ESR1 GATA3
4 uterus development GO:0060065 8.62 ESR1 GATA3

Molecular functions related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.5 ESR1 GATA3 PGR
2 nuclear receptor activity GO:0004879 9.26 ESR1 PGR
3 sequence-specific DNA binding GO:0043565 9.26 CDX2 ESR1 GATA3 PGR
4 core promoter sequence-specific DNA binding GO:0001046 9.16 ESR1 GATA3
5 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Gastric Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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