MCID: GST016
MIFTS: 41

Gastric Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Gastric Signet Ring Cell Adenocarcinoma:

Name: Gastric Signet Ring Cell Adenocarcinoma 12 15
Signet Ring Cell Gastric Adenocarcinoma 17 74
Signet Ring Cell Adenocarcinoma of the Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8025
NCIt 51 C5250
UMLS 74 C1335965

Summaries for Gastric Signet Ring Cell Adenocarcinoma

MalaCards based summary : Gastric Signet Ring Cell Adenocarcinoma, also known as signet ring cell gastric adenocarcinoma, is related to signet ring cell adenocarcinoma and adenocarcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Signet Ring Cell Adenocarcinoma is UPK2 (Uroplakin 2), and among its related pathways/superpathways are PAK Pathway and Gastric cancer. The drugs Epirubicin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and colon, and related phenotypes are cardiovascular system and cellular

Related Diseases for Gastric Signet Ring Cell Adenocarcinoma

Diseases related to Gastric Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 31.5 CDH1 CDX2
2 adenocarcinoma 10.7
3 gastric adenocarcinoma 10.6
4 embryoma 10.3 CDX2 GATA3
5 cochlear disease 10.3 GATA3 SNAI2
6 spastic paraplegia 25, autosomal recessive 10.3 FGF13 FGF2
7 sarcomatoid renal cell carcinoma 10.3 CDH1 GATA3
8 diffuse glomerulonephritis 10.3 FGF13 FGF2
9 anal paget's disease 10.3 CDX2 CEACAM5
10 mucinous adenofibroma 10.2 CDX2 CEACAM5
11 anus adenocarcinoma 10.2 CDX2 CEACAM5
12 microinvasive gastric cancer 10.2 CDH1 CDX2
13 clivus chordoma 10.2 FGF13 FGF2
14 brachydactyly, type b2 10.2 FGF13 FGF2
15 cystitis cystica 10.2 CDX2 GATA3 UPK2
16 thymus adenocarcinoma 10.2 CDX2 CEACAM5
17 cribriform carcinoma 10.2 GATA3 PGR
18 rectum adenocarcinoma 10.2 CDX2 CEACAM5
19 mucinous ovarian cystadenoma 10.2 CDX2 CEACAM5
20 gastric diffuse adenocarcinoma 10.2 CDH1 CDX2 UPK2
21 esophageal adenosquamous carcinoma 10.2 CDH1 CEACAM5
22 biliary papillomatosis 10.2 CDX2 CEACAM5
23 luminal breast carcinoma 10.2 GATA3 PGR
24 ovarian mucinous neoplasm 10.2 CDX2 CEACAM5
25 inflammatory breast carcinoma 10.2 CDH1 PGR
26 breast adenomyoepithelioma 10.2 CDH1 CEACAM5
27 breast myoepithelial neoplasm 10.2 CDH1 CEACAM5
28 clear cell acanthoma 10.1 CEACAM5 GATA3
29 infiltrative basal cell carcinoma 10.1 CDH1 CEACAM5
30 pernicious anemia 10.1
31 ascites, chylous 10.1
32 hemolytic anemia 10.1
33 thrombosis 10.1
34 squamous cell carcinoma 10.1
35 linitis plastica 10.1
36 granulomatous endometritis 10.1 CEACAM5 PGR
37 chondroid chordoma 10.1 CDH1 CEACAM5
38 intracystic papillary adenoma 10.1 CEACAM5 PGR
39 cecum adenocarcinoma 10.1 CDX2 FGF2
40 breast mucoepidermoid carcinoma 10.1 CEACAM5 PGR
41 tonsil cancer 10.1 CDH1 SNAI2
42 adenoid basal cell carcinoma 10.1 CEACAM5 PGR
43 pancreatic serous cystadenoma 10.1 CEACAM5 PGR
44 spastic paraplegia 3, autosomal dominant 10.1 CDH1 SNAI1
45 angiomatous meningioma 10.1 FGF2 PGR
46 calcifying aponeurotic fibroma 10.1 FN1 PGR
47 brachydactyly, type b1 10.1 FGF13 FGF2
48 bartholin's duct cyst 10.1 GATA3 PIP
49 lymphomatous meningitis 10.1 CEACAM5 FN1
50 tubular adenocarcinoma 10.0 CDH1 CDX2 PGR

Graphical network of the top 20 diseases related to Gastric Signet Ring Cell Adenocarcinoma:



Diseases related to Gastric Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Gastric Signet Ring Cell Adenocarcinoma

UMLS symptoms related to Gastric Signet Ring Cell Adenocarcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Signet Ring Cell Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 CDH1 CDX2 FGF2 FN1 GATA3 HPSE
2 cellular MP:0005384 10.16 CDH1 CDX2 FGF13 FGF2 FN1 GATA3
3 mortality/aging MP:0010768 9.96 CDH1 CDX2 FGF13 FGF2 FN1 GATA3
4 embryo MP:0005380 9.95 CDH1 CDX2 FN1 GATA3 PGR SNAI1
5 digestive/alimentary MP:0005381 9.91 CDH1 CDX2 GATA3 PIP SNAI1 SNAI2
6 endocrine/exocrine gland MP:0005379 9.91 CDH1 CDX2 GATA3 HPSE PGR PIP
7 integument MP:0010771 9.8 CDH1 FN1 GATA3 HPSE PGR SNAI2
8 reproductive system MP:0005389 9.56 CDH1 CDX2 FGF2 FN1 GATA3 PGR
9 neoplasm MP:0002006 9.55 CDH1 CDX2 FGF2 FN1 PGR
10 skeleton MP:0005390 9.17 CDX2 FGF2 FN1 GATA3 PGR SNAI1

Drugs & Therapeutics for Gastric Signet Ring Cell Adenocarcinoma

Drugs for Gastric Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epirubicin Approved Not Applicable 56420-45-2 41867
2
Fluorouracil Approved Not Applicable 51-21-8 3385
3
Cisplatin Approved Not Applicable 15663-27-1 2767 441203 84093

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma Recruiting NCT01717924 Not Applicable

Search NIH Clinical Center for Gastric Signet Ring Cell Adenocarcinoma

Genetic Tests for Gastric Signet Ring Cell Adenocarcinoma

Anatomical Context for Gastric Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Gastric Signet Ring Cell Adenocarcinoma:

42
Breast, Bone, Colon, Bone Marrow, Appendix, Lung, Thymus

Publications for Gastric Signet Ring Cell Adenocarcinoma

Articles related to Gastric Signet Ring Cell Adenocarcinoma:

(show all 22)
# Title Authors Year
1
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma. ( 30333909 )
2018
2
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. ( 29801472 )
2018
3
Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma. ( 28740840 )
2017
4
An Unusual Recurrence of Signet Ring Cell Gastric Adenocarcinoma Treated by Right Hemicolectomy, Pancreaticoduodenectomy, and IVC Resection: Controversies and Dilemmas of Following Standard Treatment Pathways. ( 26848413 )
2015
5
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
6
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
7
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
8
Chylous ascites due to signet ring cell gastric adenocarcinoma. ( 23238204 )
2012
9
Signet-ring cell gastric adenocarcinoma metastasizing into a primary cutaneous squamous cell carcinoma of the scalp. ( 22616597 )
2012
10
Diffuse Signet-Ring Cell Gastric Adenocarcinoma "Linitis Plastica" and Pernicious Anemia: a Rare Association. ( 22760711 )
2012
11
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
12
Colonic anastomosis and colonic polyp mucosal metastasis of signet ring cell gastric adenocarcinoma. ( 20231131 )
2010
13
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
14
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
15
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
16
A rare case of signet ring cell gastric adenocarcinoma. ( 19292116 )
2007
17
'Signet-ring' cell gastric adenocarcinoma metastatic to a neurogenous hyperplasia of the appendix. ( 17394504 )
2007
18
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
19
Epididymal metastasis from gastric signet ring cell adenocarcinoma. ( 12010596 )
2002
20
Gastric signet ring cell adenocarcinoma metastatic to the iris. ( 11239875 )
2001
21
Acquired deficiency in C1-inhibitor associated with signet ring cell gastric adenocarcinoma: a probable connection of antitumor-associated antibodies, hemolytic anemia, and complement turnover. ( 7822653 )
1995
22
Polyvinylpyrrolidone storage disease: a source of error in the diagnosis of signet ring cell gastric adenocarcinoma. ( 8191638 )
1994

Variations for Gastric Signet Ring Cell Adenocarcinoma

Expression for Gastric Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Gastric Signet Ring Cell Adenocarcinoma.

Pathways for Gastric Signet Ring Cell Adenocarcinoma

GO Terms for Gastric Signet Ring Cell Adenocarcinoma

Cellular components related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CDH1 CEACAM5 FGF13 FGF2 FN1 HPSE

Biological processes related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.95 CDX2 FGF2 SNAI1 SNAI2 UPK2
2 positive regulation of transcription, DNA-templated GO:0045893 9.72 CDH1 CDX2 FGF2 GATA3 SNAI1
3 extracellular matrix organization GO:0030198 9.71 CDH1 FGF2 FN1
4 positive regulation of protein kinase B signaling GO:0051897 9.7 FGF2 GATA3 HPSE
5 wound healing GO:0042060 9.54 FGF2 FN1 HPSE
6 negative regulation of anoikis GO:2000811 9.51 CEACAM5 SNAI2
7 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 9.49 SNAI1 SNAI2
8 animal organ morphogenesis GO:0009887 9.48 CDX2 FGF2
9 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.46 SNAI1 SNAI2
10 regulation of bicellular tight junction assembly GO:2000810 9.43 SNAI1 SNAI2
11 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.4 SNAI1 SNAI2
12 cartilage morphogenesis GO:0060536 9.26 SNAI1 SNAI2
13 paracrine signaling GO:0038001 9.16 FGF2 PGR
14 negative regulation of vitamin D biosynthetic process GO:0010957 8.96 SNAI1 SNAI2
15 aortic valve morphogenesis GO:0003180 8.8 GATA3 SNAI1 SNAI2

Molecular functions related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.55 CDX2 GATA3 PGR SNAI1 SNAI2
2 protein dimerization activity GO:0046983 9.5 GATA3 HPSE PIP
3 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 9.43 CDX2 SNAI1 SNAI2
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.26 CDX2 GATA3 SNAI1 SNAI2
5 E-box binding GO:0070888 8.8 GATA3 SNAI1 SNAI2

Sources for Gastric Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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