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MCID: GST028
MIFTS: 41

Gastric Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gastric Squamous Cell Carcinoma

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MalaCards integrated aliases for Gastric Squamous Cell Carcinoma:

Name: Gastric Squamous Cell Carcinoma 12 59 15 73
Squamous Cell Carcinoma of the Stomach 59
Squamous Cell Carcinoma of Stomach 12

Characteristics:

Orphanet epidemiological data:

59
squamous cell carcinoma of the stomach
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide);

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:5516
NCIt 50 C5475
Orphanet 59 ORPHA418959
ICD10 via Orphanet 34 C16.0 C16.1 C16.2 more
UMLS 73 C1333789
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Summaries for Gastric Squamous Cell Carcinoma

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Disease Ontology : 12 A squamous cell carcinoma that is located in the stomach.

MalaCards based summary : Gastric Squamous Cell Carcinoma, also known as squamous cell carcinoma of the stomach, is related to large cell neuroendocrine carcinoma and squamous cell carcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Squamous Cell Carcinoma is DCC (DCC Netrin 1 Receptor), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. The drugs Oxaliplatin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and ovary, and related phenotypes are craniofacial and nervous system

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Related Diseases for Gastric Squamous Cell Carcinoma

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Diseases related to Gastric Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 28.9 CHGA ENO2 KRT7 NCAM1 SYP
2 squamous cell carcinoma 10.4
3 epidermolysis bullosa simplex, dowling-meara type 10.3 KRT10 KRT5
4 dowling-degos disease 1 10.3 KITLG KRT5
5 cutaneous solitary mastocytoma 10.2 KITLG SERPINA3
6 pallister-hall syndrome 10.2 GLI1 SHH
7 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 GLI1 SHH
8 keratocystic odontogenic tumor 10.2 GLI1 SHH
9 prostate squamous cell carcinoma 10.2 KRT5 KRT7
10 necrotizing sialometaplasia 10.2 KRT5 KRT7
11 sweat gland disease 10.2 KRT5 KRT7
12 anus cancer 10.2 KRT5 KRT7
13 peritoneum cancer 10.2 KRT5 KRT7
14 breast secretory carcinoma 10.2 KRT5 KRT7
15 nasal cavity squamous cell carcinoma 10.2 KRT5 KRT7
16 cystitis cystica 10.2 KRT5 KRT7
17 pregnancy adenoma 10.2 KRT5 KRT7
18 tonsil cancer 10.2 KRT5 KRT7
19 hidradenocarcinoma 10.2 KRT5 KRT7
20 mucinous tubular and spindle renal cell carcinoma 10.2 KRT10 KRT7
21 breast squamous cell carcinoma 10.2 KRT10 KRT5
22 inverted transitional papilloma 10.2 KRT5 KRT7
23 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT10 KRT5
24 balloon cell malignant melanoma 10.2 KRT5 KRT7
25 benign breast adenomyoepithelioma 10.2 KRT5 KRT7
26 ceruminoma 10.2 KRT5 KRT7
27 malignant spiradenoma 10.2 KRT5 KRT7
28 benign mesothelioma 10.2 KRT5 KRT7
29 malignant skin fibrous histiocytoma 10.1 CHGA NCAM1
30 dermoid cyst 10.1 CHGA KRT7
31 acinar cell carcinoma 10.1 CHGA KRT7
32 cecum adenocarcinoma 10.1 CHGA KRT7
33 signet ring cell adenocarcinoma 10.1 CHGA KRT7
34 bile duct mucoepidermoid carcinoma 10.1 KRT5 KRT7
35 malignant dermis tumor 10.1 CHGA NCAM1
36 apocrine sweat gland neoplasm 10.1 KRT5 KRT7
37 breast papillary carcinoma 10.1 KRT5 SYP
38 nephrogenic adenofibroma 10.1 KRT7 NCAM1
39 anterior cranial fossa meningioma 10.1 CHGA SYP
40 pulmonary blastoma 10.1 CHGA SYP
41 pleomorphic xanthoastrocytoma 10.1 CHGA SYP
42 tanycytic ependymoma 10.1 CHGA SYP
43 pancreatoblastoma 10.1 CHGA SYP
44 non-functioning pancreatic endocrine tumor 10.1 CHGA SYP
45 binswanger's disease 10.1 CHGA SYP
46 tubular adenocarcinoma 10.1 CHGA SYP
47 cloacogenic carcinoma 10.1 ENO2 KRT5
48 adenoid cystic carcinoma 10.1 KRT5 KRT7 SERPINA3
49 immune system organ benign neoplasm 10.1 KRT7 SYP
50 spermatocele 10.1 NCAM1 SYP

Graphical network of the top 20 diseases related to Gastric Squamous Cell Carcinoma:



Diseases related to Gastric Squamous Cell Carcinoma
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Symptoms & Phenotypes for Gastric Squamous Cell Carcinoma

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UMLS symptoms related to Gastric Squamous Cell Carcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.35 ENO2 GLI1 KITLG KRT5 SHH
2 nervous system MP:0003631 9.23 CHGA DCC ENO2 GLI1 KITLG NCAM1
Sources

Drugs & Therapeutics for Gastric Squamous Cell Carcinoma

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Drugs for Gastric Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
2
leucovorin Approved Phase 2 58-05-9 6006 143
3
Pembrolizumab Approved Phase 2 1374853-91-4
4
Nivolumab Approved Phase 2 946414-94-4
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
6 Vitamin B9 Phase 2
7 10-deazaaminopterin Phase 2
8 Folic Acid Antagonists Phase 2
9 Folate Phase 2
10 Vitamin B Complex Phase 2
11 Immunoglobulins Phase 2
12 Immunologic Factors Phase 2
13 Antibodies, Monoclonal Phase 2
14 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer Completed NCT01178944 Phase 2 Oxaliplatin;Pralatrexate
2 Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer Recruiting NCT02830594 Phase 2
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Gastric Squamous Cell Carcinoma

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Genetic Tests for Gastric Squamous Cell Carcinoma

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Anatomical Context for Gastric Squamous Cell Carcinoma

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MalaCards organs/tissues related to Gastric Squamous Cell Carcinoma:

41
Lung, Skin, Ovary, Prostate, Thyroid, Thymus, Pineal

The Foundational Model of Anatomy Ontology organs/tissues related to Gastric Squamous Cell Carcinoma:

19
The Stomach
Sources

Publications for Gastric Squamous Cell Carcinoma

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Articles related to Gastric Squamous Cell Carcinoma:

(show top 50) (show all 57)
# Title Authors Year
1
Primary Gastric Squamous Cell Carcinoma. ( 29850384 )
2018
2
Primary squamous cell carcinoma of the stomach: a rare entity. ( 30511579 )
2018
3
Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report. ( 29390350 )
2017
4
Primary Squamous Cell Carcinoma of the Stomach. ( 28469507 )
2017
5
The clinicopathological features and prognostic factors of gastric squamous cell carcinoma. ( 27559983 )
2016
6
Clinicopathological Characteristics, Treatment, and Prognosis of 21 Patients with Primary Gastric Squamous Cell Carcinoma. ( 27478431 )
2016
7
Primary squamous cell carcinoma of the stomach presenting as a huge retroperitoneal tumor: a case report. ( 26181433 )
2016
8
Primary Squamous Cell Carcinoma of the Stomach: A Case Report and Review of the Literature. ( 27265923 )
2016
9
Primary squamous cell carcinoma of the stomach. ( 27528817 )
2016
10
A Rare Case of a Primary Squamous Cell Carcinoma of the Stomach Presenting as a Submucosal Mass. ( 26185704 )
2015
11
Primary squamous cell carcinoma of the stomach: a case report and literature review. ( 26464735 )
2015
12
Metastatic Squamous Cell Carcinoma of the Stomach. ( 26673808 )
2015
13
Primary pure squamous cell carcinoma of the stomach treated with neoadjuvant chemotherapy and surgical resection. ( 26838004 )
2015
14
Synchronous double cancers of colonic large cell neuroendocrine carcinoma and gastric squamous-cell carcinoma: a case report and review of literature. ( 25197393 )
2014
15
A rare case of primary squamous cell carcinoma of the stomach and a review of the 56 cases reported in Japan. ( 24765539 )
2014
16
Primary squamous cell carcinoma of the stomach: A case report. ( 25289093 )
2014
17
Squamous cell carcinoma of the stomach. ( 26012332 )
2014
18
The clinicopathologic and prognostic analysis of adenosquamous and squamous cell carcinoma of the stomach. ( 23635572 )
2013
19
Primary squamous cell carcinoma of the stomach: a rare entity. ( 23709554 )
2013
20
A case of two primary gastric malignancies: adenocarcinoma and squamous cell carcinoma of the stomach. ( 21802677 )
2012
21
Primary squamous cell carcinoma of the stomach in a 68-years-old man. ( 21166967 )
2011
22
Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia. ( 21113875 )
2010
23
Primary squamous cell carcinoma of the stomach: a case report. ( 19960279 )
2010
24
Primary squamous cell carcinoma of the stomach with paraneoplastic leukocytosis: a case report and review of literature. ( 19467693 )
2009
25
Primary squamous cell carcinoma of the stomach that developed with Menetrier's disease. ( 17443414 )
2007
26
Primary squamous cell carcinoma of the stomach: a case report with immunohistochemical and molecular biologic studies. ( 15966243 )
2005
27
Primary squamous cell carcinoma of the stomach: a case report. ( 16459645 )
2005
28
Exophytic primary squamous cell carcinoma of the stomach. ( 15065010 )
2004
29
Synchronous squamous cell carcinoma of the stomach, the lung and the skin. ( 15249720 )
2004
30
Primary squamous cell carcinoma of the stomach: a case report and review of the literature. ( 12610330 )
2003
31
Primary squamous cell carcinoma of the stomach: a case report. ( 12891931 )
2003
32
Primary squamous cell carcinoma of the stomach. Report of a case and review of literature. ( 11490793 )
2001
33
Primary squamous cell carcinoma of the stomach: a case report with a review of Japanese and Western literature. ( 10576394 )
1999
34
Primary squamous cell carcinoma of the stomach. ( 11957086 )
1999
35
Squamous cell carcinoma of the stomach. ( 11957107 )
1999
36
Gastric squamous cell carcinoma in three llamas. ( 9087939 )
1997
37
Gastric squamous cell carcinoma in three horses. ( 9412445 )
1997
38
Squamous cell carcinoma of the stomach. ( 7486450 )
1995
39
Primary squamous cell carcinoma of the stomach in a seventeen-year-old boy. ( 1472799 )
1992
40
Squamous cell carcinoma of the stomach following gastric surgery. ( 2102219 )
1990
41
Gastric squamous cell carcinoma and fascioliasis in a llama. ( 3402219 )
1988
42
Hypercalcemia in primary squamous cell carcinoma of the stomach. ( 3373475 )
1988
43
Hypercalcaemia in primary squamous cell carcinoma of the stomach. ( 3681874 )
1987
44
Squamous cell carcinoma of the stomach. ( 3699859 )
1986
45
Squamous cell carcinoma of the stomach: report of three cases. ( 3706247 )
1986
46
Primary squamous cell carcinoma of the stomach. ( 3970006 )
1985
47
Squamous cell carcinoma of the stomach: a study of four patients with comments on histogenesis. ( 4079395 )
1985
48
Six cases of squamous cell carcinoma of the stomach of the horse. ( 7106089 )
1982
49
Pleural effusion associated with squamous cell carcinoma of the stomach of a horse. ( 7250111 )
1981
50
Gastric squamous cell carcinoma in a dog. ( 7361385 )
1980
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Variations for Gastric Squamous Cell Carcinoma

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Cosmic variations for Gastric Squamous Cell Carcinoma:

9 (show all 16)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM11123 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 13
2 COSM6904034 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 13
3 COSM6904040 NOTCH2 stomach,NS,carcinoma,squamous cell carcinoma c.2898C>G p.D966E 1:119941609-119941609 13
4 COSM6904039 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 13
5 COSM6904037 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 13
6 COSM532 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 13
7 COSM498 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 13
8 COSM487 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 13
9 COSM562339 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 13
10 COSM6904038 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 13
11 COSM99664 stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 13
12 COSM3448605 stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 13
13 COSM1649339 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 13
14 COSM6904035 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 13
15 COSM3378442 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 13
16 COSM6904036 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 13
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Expression for Gastric Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Gastric Squamous Cell Carcinoma.
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Pathways for Gastric Squamous Cell Carcinoma

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Pathways related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 66
Show member pathways
 12.84 DCC KITLG KRT10 KRT5 KRT7 NCAM1
2
Pathways in cancer 37
12.28 DCC GLI1 KITLG SHH
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.26 KITLG NCAM1 SHH
4
Dopaminergic Neurogenesis 1
10.8 GLI1 SHH
5
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.7 NCAM1 SHH SYP
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GO Terms for Gastric Squamous Cell Carcinoma

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Cellular components related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT10 KRT5 KRT7
2 extracellular space GO:0005615 9.1 CHGA ENO2 KITLG KRT10 SERPINA3 SHH

Biological processes related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.63 DCC NCAM1 SHH
2 keratinization GO:0031424 9.54 KRT10 KRT5 KRT7
3 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 DCC KITLG
4 positive regulation of smoothened signaling pathway GO:0045880 9.4 GLI1 SHH
5 cornification GO:0070268 9.33 KRT10 KRT5 KRT7
6 digestive tract morphogenesis GO:0048546 9.32 GLI1 SHH
7 prostate gland development GO:0030850 9.26 GLI1 SHH
8 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 8.96 GLI1 SHH
9 ventral midline development GO:0007418 8.62 GLI1 SHH
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Sources for Gastric Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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