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MCID: GST028
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Gastric Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gastric Squamous Cell Carcinoma

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MalaCards integrated aliases for Gastric Squamous Cell Carcinoma:

Name: Gastric Squamous Cell Carcinoma 12 60 15 17 74
Squamous Cell Carcinoma of the Stomach 60
Squamous Cell Carcinoma of Stomach 12

Characteristics:

Orphanet epidemiological data:

60
squamous cell carcinoma of the stomach
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide);

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:5516
NCIt 51 C5475
ICD10 via Orphanet 35 C16.0 C16.1 C16.2 more
Orphanet 60 ORPHA418959
UMLS 74 C1333789
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Summaries for Gastric Squamous Cell Carcinoma

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Disease Ontology : 12 A squamous cell carcinoma that is located in the stomach.

MalaCards based summary : Gastric Squamous Cell Carcinoma, also known as squamous cell carcinoma of the stomach, is related to large cell neuroendocrine carcinoma and epidermolysis bullosa simplex, dowling-meara type, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Squamous Cell Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. The drugs leucovorin and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and colon, and related phenotypes are cellular and digestive/alimentary

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Related Diseases for Gastric Squamous Cell Carcinoma

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Diseases related to Gastric Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 28.4 CHGA ENO2 KRT7 NCAM1 SYP
2 epidermolysis bullosa simplex, dowling-meara type 10.5 KRT10 KRT5
3 epidermolysis bullosa simplex with mottled pigmentation 10.5 KRT10 KRT5
4 breast squamous cell carcinoma 10.5 KRT10 KRT5
5 cutaneous solitary mastocytoma 10.4 KITLG SERPINA3
6 dowling-degos disease 1 10.4 KITLG KRT5
7 squamous cell carcinoma 10.4
8 pallister-hall syndrome 10.4 GLI1 SHH
9 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.4 GLI1 SHH
10 prostate squamous cell carcinoma 10.3 KRT5 KRT7
11 necrotizing sialometaplasia 10.3 KRT5 KRT7
12 peritoneum cancer 10.3 KRT5 KRT7
13 breast secretory carcinoma 10.3 KRT5 KRT7
14 nasal cavity squamous cell carcinoma 10.3 KRT5 KRT7
15 pregnancy adenoma 10.3 KRT5 KRT7
16 mucinous tubular and spindle renal cell carcinoma 10.3 KRT10 KRT7
17 bowen's disease 10.3 KRT10 KRT7
18 endocervical adenocarcinoma 10.3 CDX2 KRT7
19 mucinous bronchioloalveolar adenocarcinoma 10.3 CDX2 KRT7
20 appendix cancer 10.3 CDX2 KRT7
21 chronic cystitis 10.3 CDX2 KRT7
22 rectum adenocarcinoma 10.3 CDX2 KRT7
23 vulva adenocarcinoma 10.3 CDX2 KRT7
24 prostatic acinar adenocarcinoma 10.3 CDX2 KRT7
25 ampulla of vater adenocarcinoma 10.3 CDX2 KRT7
26 ovarian mucinous adenocarcinoma 10.3 CDX2 KRT7
27 anal canal adenocarcinoma 10.3 CDX2 KRT7
28 bladder adenocarcinoma 10.3 CDX2 KRT7
29 thymus adenocarcinoma 10.3 CDX2 KRT7
30 nasal cavity adenocarcinoma 10.3 CDX2 KRT7
31 biliary papillomatosis 10.3 CDX2 KRT7
32 appendix disease 10.3 CDX2 KRT7
33 gastric diffuse adenocarcinoma 10.3 CDX2 KRT7
34 schneiderian carcinoma 10.3 KRT5 SYP
35 inverted transitional papilloma 10.2 KRT5 KRT7
36 vaginal benign neoplasm 10.2 CDX2 CHGA
37 balloon cell malignant melanoma 10.2 KRT5 KRT7
38 benign breast adenomyoepithelioma 10.2 KRT5 KRT7
39 vaginal adenoma 10.2 CDX2 CHGA
40 ceruminoma 10.2 KRT5 KRT7
41 vaginal tubulovillous adenoma 10.2 CDX2 CHGA
42 malignant spiradenoma 10.2 KRT5 KRT7
43 dermoid cyst 10.2 CHGA KRT7
44 benign mesothelioma 10.2 KRT5 KRT7
45 appendix adenocarcinoma 10.2 CDX2 KRT7
46 vulvar intraepithelial neoplasia 10.2 KRT10 KRT7
47 intestinal perforation 10.2 KRT7 NCAM1
48 anus adenocarcinoma 10.2 CDX2 KRT7
49 bile duct mucoepidermoid carcinoma 10.2 KRT5 KRT7
50 glandular cystitis 10.2 CDX2 KRT7

Graphical network of the top 20 diseases related to Gastric Squamous Cell Carcinoma:



Diseases related to Gastric Squamous Cell Carcinoma
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Symptoms & Phenotypes for Gastric Squamous Cell Carcinoma

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UMLS symptoms related to Gastric Squamous Cell Carcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Squamous Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 CDX2 DCC ENO2 GLI1 KITLG KRT7
2 digestive/alimentary MP:0005381 9.63 CDX2 DCC GLI1 KITLG KRT5 SHH
3 neoplasm MP:0002006 9.35 CDX2 DCC GLI1 KITLG SHH
4 nervous system MP:0003631 9.23 CHGA DCC ENO2 GLI1 KITLG NCAM1
Sources

Drugs & Therapeutics for Gastric Squamous Cell Carcinoma

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Drugs for Gastric Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2 58-05-9 6006 143
2
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 6857599 5310940 9887054 43805
3
Pembrolizumab Approved Phase 2 1374853-91-4
4
nivolumab Approved Phase 2 946414-94-4
5
Ipilimumab Approved Phase 2 477202-00-9
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
7 10-deazaaminopterin Phase 2
8 Folate Phase 2
9 Folic Acid Antagonists Phase 2
10 Vitamin B9 Phase 2
11 Vitamin B Complex Phase 2
12 Antineoplastic Agents, Immunological Phase 2
13 Immunoglobulins Phase 2
14 Antibodies, Monoclonal Phase 2
15 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer Completed NCT01178944 Phase 2 Oxaliplatin;Pralatrexate
2 Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer Recruiting NCT02830594 Phase 2
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Gastric Squamous Cell Carcinoma

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Genetic Tests for Gastric Squamous Cell Carcinoma

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Anatomical Context for Gastric Squamous Cell Carcinoma

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MalaCards organs/tissues related to Gastric Squamous Cell Carcinoma:

42
Lung, Skin, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Gastric Squamous Cell Carcinoma:

20
The Stomach
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Publications for Gastric Squamous Cell Carcinoma

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Articles related to Gastric Squamous Cell Carcinoma:

(show top 50) (show all 59)
# Title Authors Year
1
Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis. ( 30788163 )
2019
2
The origin of p40-negative and CDX2-positive primary squamous cell carcinoma of the stomach: case report. ( 30890174 )
2019
3
Primary Gastric Squamous Cell Carcinoma. ( 29850384 )
2018
4
Primary squamous cell carcinoma of the stomach: a rare entity. ( 30511579 )
2018
5
Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report. ( 29390350 )
2017
6
Primary Squamous Cell Carcinoma of the Stomach. ( 28469507 )
2017
7
The clinicopathological features and prognostic factors of gastric squamous cell carcinoma. ( 27559983 )
2016
8
Clinicopathological Characteristics, Treatment, and Prognosis of 21 Patients with Primary Gastric Squamous Cell Carcinoma. ( 27478431 )
2016
9
Primary squamous cell carcinoma of the stomach presenting as a huge retroperitoneal tumor: a case report. ( 26181433 )
2016
10
Primary Squamous Cell Carcinoma of the Stomach: A Case Report and Review of the Literature. ( 27265923 )
2016
11
Primary squamous cell carcinoma of the stomach. ( 27528817 )
2016
12
A Rare Case of a Primary Squamous Cell Carcinoma of the Stomach Presenting as a Submucosal Mass. ( 26185704 )
2015
13
Primary squamous cell carcinoma of the stomach: a case report and literature review. ( 26464735 )
2015
14
Metastatic Squamous Cell Carcinoma of the Stomach. ( 26673808 )
2015
15
Primary pure squamous cell carcinoma of the stomach treated with neoadjuvant chemotherapy and surgical resection. ( 26838004 )
2015
16
Synchronous double cancers of colonic large cell neuroendocrine carcinoma and gastric squamous-cell carcinoma: a case report and review of literature. ( 25197393 )
2014
17
A rare case of primary squamous cell carcinoma of the stomach and a review of the 56 cases reported in Japan. ( 24765539 )
2014
18
Primary squamous cell carcinoma of the stomach: A case report. ( 25289093 )
2014
19
Squamous cell carcinoma of the stomach. ( 26012332 )
2014
20
The clinicopathologic and prognostic analysis of adenosquamous and squamous cell carcinoma of the stomach. ( 23635572 )
2013
21
Primary squamous cell carcinoma of the stomach: a rare entity. ( 23709554 )
2013
22
A case of two primary gastric malignancies: adenocarcinoma and squamous cell carcinoma of the stomach. ( 21802677 )
2012
23
Primary squamous cell carcinoma of the stomach in a 68-years-old man. ( 21166967 )
2011
24
Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia. ( 21113875 )
2010
25
Primary squamous cell carcinoma of the stomach: a case report. ( 19960279 )
2010
26
Primary squamous cell carcinoma of the stomach with paraneoplastic leukocytosis: a case report and review of literature. ( 19467693 )
2009
27
Primary squamous cell carcinoma of the stomach that developed with Menetrier's disease. ( 17443414 )
2007
28
Primary squamous cell carcinoma of the stomach: a case report with immunohistochemical and molecular biologic studies. ( 15966243 )
2005
29
Primary squamous cell carcinoma of the stomach: a case report. ( 16459645 )
2005
30
Exophytic primary squamous cell carcinoma of the stomach. ( 15065010 )
2004
31
Synchronous squamous cell carcinoma of the stomach, the lung and the skin. ( 15249720 )
2004
32
Primary squamous cell carcinoma of the stomach: a case report and review of the literature. ( 12610330 )
2003
33
Primary squamous cell carcinoma of the stomach: a case report. ( 12891931 )
2003
34
Primary squamous cell carcinoma of the stomach. Report of a case and review of literature. ( 11490793 )
2001
35
Primary squamous cell carcinoma of the stomach: a case report with a review of Japanese and Western literature. ( 10576394 )
1999
36
Primary squamous cell carcinoma of the stomach. ( 11957086 )
1999
37
Squamous cell carcinoma of the stomach. ( 11957107 )
1999
38
Gastric squamous cell carcinoma in three llamas. ( 9087939 )
1997
39
Gastric squamous cell carcinoma in three horses. ( 9412445 )
1997
40
Squamous cell carcinoma of the stomach. ( 7486450 )
1995
41
Primary squamous cell carcinoma of the stomach in a seventeen-year-old boy. ( 1472799 )
1992
42
Squamous cell carcinoma of the stomach following gastric surgery. ( 2102219 )
1990
43
Gastric squamous cell carcinoma and fascioliasis in a llama. ( 3402219 )
1988
44
Hypercalcemia in primary squamous cell carcinoma of the stomach. ( 3373475 )
1988
45
Hypercalcaemia in primary squamous cell carcinoma of the stomach. ( 3681874 )
1987
46
Squamous cell carcinoma of the stomach. ( 3699859 )
1986
47
Squamous cell carcinoma of the stomach: report of three cases. ( 3706247 )
1986
48
Primary squamous cell carcinoma of the stomach. ( 3970006 )
1985
49
Squamous cell carcinoma of the stomach: a study of four patients with comments on histogenesis. ( 4079395 )
1985
50
Six cases of squamous cell carcinoma of the stomach of the horse. ( 7106089 )
1982
Sources

Variations for Gastric Squamous Cell Carcinoma

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Cosmic variations for Gastric Squamous Cell Carcinoma:

9 (show all 16)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM11123 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 0
2 COSM6904034 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 0
3 COSM6904040 NOTCH2 stomach,NS,carcinoma,squamous cell carcinoma c.2898C>G p.D966E 1:119941609-119941609 0
4 COSM6904039 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 0
5 COSM6904037 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 0
6 COSM532 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 0
7 COSM498 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 0
8 COSM487 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 0
9 COSM562339 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 0
10 COSM6904038 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 0
11 COSM99664 stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 0
12 COSM3448605 stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 0
13 COSM1649339 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 0
14 COSM6904035 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 0
15 COSM3378442 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 0
16 COSM6904036 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 0
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Expression for Gastric Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Gastric Squamous Cell Carcinoma.
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Pathways for Gastric Squamous Cell Carcinoma

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Pathways related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 67
Show member pathways
 12.84 DCC KITLG KRT10 KRT5 KRT7 NCAM1
2
Pathways in cancer 38
12.39 DCC GLI1 KITLG SHH
3
Wnt / Hedgehog / Notch 4
11.69 CDX2 GLI1 SHH
4
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.05 CDX2 KITLG NCAM1 SHH
5
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.03 NCAM1 SHH SYP
6
Dopaminergic Neurogenesis 1
10.8 GLI1 SHH
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GO Terms for Gastric Squamous Cell Carcinoma

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Biological processes related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.33 KRT10 KRT5 KRT7
2 digestive tract morphogenesis GO:0048546 9.32 GLI1 SHH
3 prostate gland development GO:0030850 9.26 GLI1 SHH
4 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 8.96 GLI1 SHH
5 ventral midline development GO:0007418 8.62 GLI1 SHH
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Sources for Gastric Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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