MCID: GST028
MIFTS: 36

Gastric Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Gastric Squamous Cell Carcinoma

MalaCards integrated aliases for Gastric Squamous Cell Carcinoma:

Name: Gastric Squamous Cell Carcinoma 12 58 15 17 71
Squamous Cell Carcinoma of the Stomach 58
Squamous Cell Carcinoma of Stomach 12

Characteristics:

Orphanet epidemiological data:

58
squamous cell carcinoma of the stomach
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide);

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:5516
NCIt 50 C5475
SNOMED-CT 67 766980008
ICD10 via Orphanet 33 C16.0 C16.1 C16.2 more
Orphanet 58 ORPHA418959
UMLS 71 C1333789

Summaries for Gastric Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the stomach.

MalaCards based summary : Gastric Squamous Cell Carcinoma, also known as squamous cell carcinoma of the stomach, is related to papilloma and adenosquamous carcinoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Squamous Cell Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include stomach, skin and cervix.

Related Diseases for Gastric Squamous Cell Carcinoma

Diseases related to Gastric Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 papilloma 30.0 KRT7 KRT5 KRT10
2 adenosquamous carcinoma 30.0 SERPINA3 KRT7 KRT5
3 squamous cell carcinoma 10.5
4 gastric adenocarcinoma 10.3
5 rare tumor 10.3
6 dysphagia 10.3
7 sarcomatoid squamous cell skin carcinoma 10.2 SERPINA3 KRT5
8 breast secretory carcinoma 10.2 SERPINA3 KRT5
9 breast malignant phyllodes tumor 10.2 SERPINA3 KRT5
10 central nervous system vasculitis 10.2 SERPINA3 CCR6
11 heart cancer 10.2 SERPINA3 KRT5
12 progressive relapsing multiple sclerosis 10.2 SERPINA3 CCR6
13 hypersensitivity reaction type iii disease 10.2 SERPINA3 CCR6
14 gingival disease 10.2 SERPINA3 CCR6
15 plasma protein metabolism disease 10.2 SERPINA3 CCR6
16 autoimmune disease of blood 10.2 SERPINA3 CCR6
17 middle ear disease 10.2 SERPINA3 CCR6
18 panuveitis 10.2 SERPINA3 CCR6
19 lipoadenoma 10.2 SERPINA3 KRT7
20 sebaceous gland disease 10.2 SERPINA3 CCR6
21 liver sarcoma 10.2 SERPINA3 KRT7
22 fibroma 10.2 SERPINA3 KRT7
23 coronavirus infectious disease 10.2 SERPINA3 CCR6
24 acanthoma 10.2 KRT5 KRT10
25 autoimmune disease of cardiovascular system 10.2 SERPINA3 CCR6
26 papillary adenoma 10.2 KRT7 KRT5
27 ureter squamous cell carcinoma 10.2 KRT7 KRT5
28 inverted transitional papilloma 10.2 KRT7 KRT5
29 ceruminoma 10.2 KRT7 KRT5
30 syphilis 10.2 SERPINA3 CCR6
31 papillary cystadenocarcinoma 10.2 SERPINA3 KRT7
32 ureter adenocarcinoma 10.2 KRT7 KRT5
33 subareolar duct papillomatosis 10.2 KRT7 KRT5
34 malignant acrospiroma 10.2 KRT7 KRT5
35 nipple benign neoplasm 10.2 KRT7 KRT5
36 auditory system benign neoplasm 10.2 KRT7 KRT5
37 microinvasive cervical squamous cell carcinoma 10.2 KRT7 KRT5
38 ceruminous adenocarcinoma 10.2 KRT7 KRT5
39 cutaneous mucoepidermoid carcinoma 10.2 KRT7 KRT5
40 external ear carcinoma 10.2 KRT7 KRT5
41 hidradenoma 10.2 KRT7 KRT5
42 benign breast adenomyoepithelioma 10.2 KRT7 KRT5
43 eccrine adenocarcinoma 10.2 KRT7 KRT5
44 vein disease 10.2 SERPINA3 CCR6
45 lung clear cell carcinoma 10.2 KRT7 KRT5
46 vulvar apocrine adenocarcinoma 10.2 KRT7 KRT5
47 papillary squamous carcinoma 10.2 KRT7 KRT5
48 necrotizing sialometaplasia 10.2 KRT7 KRT5
49 sensory organ benign neoplasm 10.2 KRT7 KRT5
50 malignant syringoma 10.2 KRT7 KRT5

Graphical network of the top 20 diseases related to Gastric Squamous Cell Carcinoma:



Diseases related to Gastric Squamous Cell Carcinoma

Symptoms & Phenotypes for Gastric Squamous Cell Carcinoma

UMLS symptoms related to Gastric Squamous Cell Carcinoma:


abdominal pain, dyspepsia

Drugs & Therapeutics for Gastric Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Gastric Squamous Cell Carcinoma

Genetic Tests for Gastric Squamous Cell Carcinoma

Anatomical Context for Gastric Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gastric Squamous Cell Carcinoma:

19
Stomach

MalaCards organs/tissues related to Gastric Squamous Cell Carcinoma:

40
Skin, Cervix

Publications for Gastric Squamous Cell Carcinoma

Articles related to Gastric Squamous Cell Carcinoma:

(show top 50) (show all 104)
# Title Authors PMID Year
1
A rare case of gastric squamous-cell carcinoma metastasized from the cervix. 61
32712841 2020
2
Equus caballus papillomavirus type 2 (EcPV2) in co-occurring vulvar and gastric lesions of a pony. 61
32590224 2020
3
Primary gastric squamous cell carcinoma presenting as a large submucosal mass: A case report and literature review. 61
32899097 2020
4
Gastric squamous cell carcinoma presenting in ascites: Negative to P63 and P40 after one course of chemotherapy. 61
32365276 2020
5
Primary squamous cell carcinoma of the stomach: a rare case report. 61
31215208 2019
6
Exophytic primary gastric squamous cell carcinoma and H. pylori gastritis. 61
31296623 2019
7
A first case of primary gastric verrucous carcinoma with isolated squamous epithelium in the stomach. 61
30761414 2019
8
A type of neoplasia deadlier than gastric adenocarcinoma? Report of a case of primary gastric squamous cell carcinoma. 61
31255175 2019
9
Primary squamous cell carcinoma of the stomach: a rare entity. 61
30511579 2019
10
The origin of p40-negative and CDX2-positive primary squamous cell carcinoma of the stomach: case report. 61
30890174 2019
11
[Metachronous Gastric Intramural Metastasis following Esophageal Cancer ESD-A Case Study]. 61
30914617 2019
12
Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis. 61
30788163 2019
13
Primary lung squamous cell carcinoma with gastric metastasis: A case report. 61
30561123 2019
14
Metastatic Primary Gastric Squamous Cell Carcinoma: An Uncommon Presentation of a Rare Malignancy. 61
31687225 2019
15
[Primary squamous cell carcinoma of the stomach. Report of three cases]. 61
30724986 2018
16
Paget's disease derived in situ from reserve cell hyperplasia, squamous metaplasia, and squamous cell carcinoma of the esophagogastric junction: a case report. 61
30046968 2018
17
Primary Gastric Squamous Cell Carcinoma. 61
29850384 2018
18
Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report. 61
29390350 2017
19
Primary Squamous Cell Carcinoma of the Stomach. 61
28469507 2017
20
The clinicopathological features and prognostic factors of gastric squamous cell carcinoma. 61
27559983 2016
21
Primary squamous cell carcinoma of the stomach presenting as a huge retroperitoneal tumor: a case report. 61
26181433 2016
22
Primary Squamous Cell Carcinoma of the Stomach: A Case Report and Review of the Literature. 61
27265923 2016
23
Primary squamous cell carcinoma of the stomach. 61
27528817 2016
24
Clinicopathological Characteristics, Treatment, and Prognosis of 21 Patients with Primary Gastric Squamous Cell Carcinoma. 61
27478431 2016
25
Metastatic Squamous Cell Carcinoma of the Stomach. 61
26673808 2015
26
Primary pure squamous cell carcinoma of the stomach treated with neoadjuvant chemotherapy and surgical resection. 61
26838004 2015
27
Primary squamous cell carcinoma of the stomach: a case report and literature review. 61
26464735 2015
28
A Rare Case of a Primary Squamous Cell Carcinoma of the Stomach Presenting as a Submucosal Mass. 61
26185704 2015
29
Primary squamous cell carcinoma of the stomach: A case report. 61
25289093 2014
30
Squamous cell carcinoma of the stomach. 61
26012332 2014
31
A rare case of primary squamous cell carcinoma of the stomach and a review of the 56 cases reported in Japan. 61
24765539 2014
32
Synchronous double cancers of colonic large cell neuroendocrine carcinoma and gastric squamous-cell carcinoma: a case report and review of literature. 61
25197393 2014
33
Role of genetic variants of deleted in colorectal carcinoma (DCC) polymorphisms and esophageal and gastric cancers risk in Kashmir Valley and meta-analysis. 61
23765761 2013
34
Primary squamous cell carcinoma of the stomach: a rare entity. 61
23709554 2013
35
The clinicopathologic and prognostic analysis of adenosquamous and squamous cell carcinoma of the stomach. 61
23635572 2013
36
Primary squamous cell carcinoma in the gastric remnant. 61
22350299 2012
37
A case of two primary gastric malignancies: adenocarcinoma and squamous cell carcinoma of the stomach. 61
21802677 2012
38
[Diagnostic assessment of peritoneal fluid cytology in horses with abdominal neoplasia]. 61
22526721 2012
39
Primary squamous cell carcinoma of the stomach in a 68-years-old man. 61
21166967 2011
40
Immunohistochemical characterization of a squamous cell carcinoma in a harbour porpoise (Phocoena phocoena) from German waters. 61
20096418 2010
41
Primary squamous cell carcinoma of the stomach: a case report. 61
19960279 2010
42
[Histological complete response in a case of primary squamous cell carcinoma of the stomach treated by chemotherapy with docetaxel and cisplatin plus 5-fluorouracil]. 61
20154491 2010
43
Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia. 61
21113875 2010
44
[A case of the gastric squamous cell carcinoma recurred in the kidney 5 years and 4 months after curative resection]. 61
20037413 2009
45
Primary squamous cell carcinoma of the stomach with paraneoplastic leukocytosis: a case report and review of literature. 61
19467693 2009
46
Primary squamous cell carcinoma of the stomach that developed with Menetrier's disease. 61
17443414 2007
47
Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma. 61
16810741 2006
48
[Clinicopathological features and differences of p53 and Ki-67 expression in adenosquamous and squamous cell carcinomas of the stomach]. 61
16809949 2006
49
Squamous cell carcinoma of stomach. 61
17089621 2006
50
Primary squamous cell carcinoma of the stomach: a case report. 61
16459645 2005

Variations for Gastric Squamous Cell Carcinoma

Cosmic variations for Gastric Squamous Cell Carcinoma:

9 (show top 50) (show all 55)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122874337 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
2 COSM87899067 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
3 COSM112389930 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
4 COSM122272106 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.442A>G p.R148G 17:7673782-7673782 9
5 COSM144422902 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.976C>T p.H326Y 17:7670616-7670616 9
6 COSM121876918 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.442A>G p.R148G 17:7673782-7673782 9
7 COSM144310794 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
8 COSM105621035 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.782+399A>G p.? 17:7673782-7673782 9
9 COSM143271103 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
10 COSM106188079 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
11 COSM143944515 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.361A>G p.R121G 17:7673782-7673782 9
12 COSM142837846 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
13 COSM144131149 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.1060C>T p.H354Y 17:7670616-7670616 9
14 COSM111894158 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 9
15 COSM144651833 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
16 COSM122021881 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
17 COSM142953005 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
18 COSM144067731 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
19 COSM88054450 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 9
20 COSM143157273 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.361A>G p.R121G 17:7673782-7673782 9
21 COSM144797256 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
22 COSM93320759 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.993+2919C>T p.? 17:7670616-7670616 9
23 COSM143501622 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
24 COSM145018343 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
25 COSM142695528 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.976C>T p.H326Y 17:7670616-7670616 9
26 COSM145143529 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.976C>T p.H326Y 17:7670616-7670616 9
27 COSM144199360 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.616C>T p.H206Y 17:7670616-7670616 9
28 COSM105773940 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.782+3565C>T p.? 17:7670616-7670616 9
29 COSM144014053 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.805A>G p.R269G 17:7673782-7673782 9
30 COSM106053774 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
31 COSM112254260 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
32 COSM142560887 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
33 COSM122401099 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.697C>T p.H233Y 17:7670616-7670616 9
34 COSM122734668 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.442A>G p.R148G 17:7673782-7673782 9
35 COSM93184392 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
36 COSM143371515 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
37 COSM144087500 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.361A>G p.R121G 17:7673782-7673782 9
38 COSM111759216 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
39 COSM88395179 NOTCH2 stomach,NS,carcinoma,squamous cell carcinoma c.2898C>G p.D966E 1:119941609-119941609 9
40 COSM87657983 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 9
41 COSM87657993 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 9
42 COSM134990131 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
43 COSM134614942 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
44 COSM91859734 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
45 COSM87804028 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
46 COSM91331222 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 9
47 COSM91331151 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
48 COSM101967270 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
49 COSM101951599 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
50 COSM105721452 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 9

Expression for Gastric Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gastric Squamous Cell Carcinoma.

Pathways for Gastric Squamous Cell Carcinoma

Pathways related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 KRT7 KRT5 KRT10
2
Show member pathways
11.25 KRT7 KRT5 KRT10

GO Terms for Gastric Squamous Cell Carcinoma

Cellular components related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT7 KRT5 KRT10
2 extracellular exosome GO:0070062 9.1 UPK3A SERPINA3 KRT7 KRT5 KRT10 IST1

Biological processes related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT7 KRT5 KRT10
2 cornification GO:0070268 8.8 KRT7 KRT5 KRT10

Sources for Gastric Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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