MCID: GST028
MIFTS: 36

Gastric Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Gastric Squamous Cell Carcinoma

MalaCards integrated aliases for Gastric Squamous Cell Carcinoma:

Name: Gastric Squamous Cell Carcinoma 12 58 15 17 71
Squamous Cell Carcinoma of the Stomach 58
Squamous Cell Carcinoma of Stomach 12

Characteristics:

Orphanet epidemiological data:

58
squamous cell carcinoma of the stomach
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide);

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:5516
NCIt 49 C5475
SNOMED-CT 67 766980008
ICD10 via Orphanet 33 C16.0 C16.1 C16.2 more
Orphanet 58 ORPHA418959
UMLS 71 C1333789

Summaries for Gastric Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the stomach.

MalaCards based summary : Gastric Squamous Cell Carcinoma, also known as squamous cell carcinoma of the stomach, is related to adenosquamous carcinoma and papilloma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Squamous Cell Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include stomach, lung and colon.

Related Diseases for Gastric Squamous Cell Carcinoma

Diseases related to Gastric Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 29.8 SERPINA3 KRT7 KRT5
2 papilloma 29.3 KRT7 KRT5 KRT10 CCR6
3 squamous cell carcinoma 10.5
4 sarcomatoid squamous cell skin carcinoma 10.3 SERPINA3 KRT5
5 breast secretory carcinoma 10.3 SERPINA3 KRT5
6 breast malignant phyllodes tumor 10.3 SERPINA3 KRT5
7 central nervous system vasculitis 10.3 SERPINA3 CCR6
8 gastric adenocarcinoma 10.3
9 bullous skin disease 10.3 SERPINA3 CCR6
10 pyelitis 10.3 SERPINA3 CCR6
11 hypersensitivity reaction type iii disease 10.3 SERPINA3 CCR6
12 plasma protein metabolism disease 10.2 SERPINA3 CCR6
13 gingival disease 10.2 SERPINA3 CCR6
14 autoimmune disease of blood 10.2 SERPINA3 CCR6
15 lipoadenoma 10.2 SERPINA3 KRT7
16 liver sarcoma 10.2 SERPINA3 KRT7
17 rare tumor 10.2
18 panuveitis 10.2 SERPINA3 CCR6
19 middle ear disease 10.2 SERPINA3 CCR6
20 papillary cystadenocarcinoma 10.2 SERPINA3 KRT7
21 ureter squamous cell carcinoma 10.2 KRT7 KRT5
22 inverted transitional papilloma 10.2 KRT7 KRT5
23 sebaceous gland disease 10.2 SERPINA3 CCR6
24 ureter adenocarcinoma 10.2 KRT7 KRT5
25 ceruminoma 10.2 KRT7 KRT5
26 malignant acrospiroma 10.2 KRT7 KRT5
27 microinvasive cervical squamous cell carcinoma 10.2 KRT7 KRT5
28 subareolar duct papillomatosis 10.2 KRT7 KRT5
29 cutaneous mucoepidermoid carcinoma 10.2 KRT7 KRT5
30 nipple benign neoplasm 10.2 KRT7 KRT5
31 secretory meningioma 10.2 SERPINA3 KRT7
32 benign breast adenomyoepithelioma 10.2 KRT7 KRT5
33 auditory system benign neoplasm 10.2 KRT7 KRT5
34 ceruminous adenocarcinoma 10.2 KRT7 KRT5
35 eccrine adenocarcinoma 10.2 KRT7 KRT5
36 external ear carcinoma 10.2 KRT7 KRT5
37 vulvar apocrine adenocarcinoma 10.2 KRT7 KRT5
38 middle ear adenoma 10.2 KRT7 KRT5
39 lung clear cell carcinoma 10.2 KRT7 KRT5
40 necrotizing sialometaplasia 10.2 KRT7 KRT5
41 sensory organ benign neoplasm 10.2 KRT7 KRT5
42 autoimmune disease of skin and connective tissue 10.2 SERPINA3 CCR6
43 squamous cell bile duct carcinoma 10.2 KRT7 KRT5
44 bile duct mucoepidermoid carcinoma 10.2 KRT7 KRT5
45 ovarian mucinous adenocarcinoma 10.2 SERPINA3 KRT7
46 breast mucinous carcinoma 10.2 KRT7 KRT5
47 clear cell hidradenoma 10.2 KRT7 KRT5
48 hidradenoma 10.2 KRT7 KRT5
49 middle ear adenocarcinoma 10.2 KRT7 KRT5
50 malignant biphasic mesothelioma 10.2 KRT7 KRT5

Graphical network of the top 20 diseases related to Gastric Squamous Cell Carcinoma:



Diseases related to Gastric Squamous Cell Carcinoma

Symptoms & Phenotypes for Gastric Squamous Cell Carcinoma

UMLS symptoms related to Gastric Squamous Cell Carcinoma:


abdominal pain, dyspepsia

Drugs & Therapeutics for Gastric Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Gastric Squamous Cell Carcinoma

Genetic Tests for Gastric Squamous Cell Carcinoma

Anatomical Context for Gastric Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gastric Squamous Cell Carcinoma:

19
Stomach

MalaCards organs/tissues related to Gastric Squamous Cell Carcinoma:

40
Lung, Colon, Kidney, Skin

Publications for Gastric Squamous Cell Carcinoma

Articles related to Gastric Squamous Cell Carcinoma:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Gastric squamous cell carcinoma presenting in ascites: Negative to P63 and P40 after one course of chemotherapy. 61
32365276 2020
2
A first case of primary gastric verrucous carcinoma with isolated squamous epithelium in the stomach. 61
30761414 2019
3
Exophytic primary gastric squamous cell carcinoma and H. pylori gastritis. 61
31296623 2019
4
Primary squamous cell carcinoma of the stomach: a rare case report. 61
31215208 2019
5
A type of neoplasia deadlier than gastric adenocarcinoma? Report of a case of primary gastric squamous cell carcinoma. 61
31255175 2019
6
The origin of p40-negative and CDX2-positive primary squamous cell carcinoma of the stomach: case report. 61
30890174 2019
7
[Metachronous Gastric Intramural Metastasis following Esophageal Cancer ESD-A Case Study]. 61
30914617 2019
8
Primary squamous cell carcinoma of the stomach: a rare entity. 61
30511579 2019
9
Primary lung squamous cell carcinoma with gastric metastasis: A case report. 61
30561123 2019
10
Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis. 61
30788163 2019
11
Metastatic Primary Gastric Squamous Cell Carcinoma: An Uncommon Presentation of a Rare Malignancy. 61
31687225 2019
12
[Primary squamous cell carcinoma of the stomach. Report of three cases]. 61
30724986 2018
13
Paget's disease derived in situ from reserve cell hyperplasia, squamous metaplasia, and squamous cell carcinoma of the esophagogastric junction: a case report. 61
30046968 2018
14
Primary Gastric Squamous Cell Carcinoma. 61
29850384 2018
15
Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report. 61
29390350 2017
16
Primary Squamous Cell Carcinoma of the Stomach. 61
28469507 2017
17
The clinicopathological features and prognostic factors of gastric squamous cell carcinoma. 61
27559983 2016
18
Primary squamous cell carcinoma of the stomach presenting as a huge retroperitoneal tumor: a case report. 61
26181433 2016
19
Primary Squamous Cell Carcinoma of the Stomach: A Case Report and Review of the Literature. 61
27265923 2016
20
Primary squamous cell carcinoma of the stomach. 61
27528817 2016
21
Clinicopathological Characteristics, Treatment, and Prognosis of 21 Patients with Primary Gastric Squamous Cell Carcinoma. 61
27478431 2016
22
Metastatic Squamous Cell Carcinoma of the Stomach. 61
26673808 2015
23
Primary pure squamous cell carcinoma of the stomach treated with neoadjuvant chemotherapy and surgical resection. 61
26838004 2015
24
Primary squamous cell carcinoma of the stomach: a case report and literature review. 61
26464735 2015
25
A Rare Case of a Primary Squamous Cell Carcinoma of the Stomach Presenting as a Submucosal Mass. 61
26185704 2015
26
Primary squamous cell carcinoma of the stomach: A case report. 61
25289093 2014
27
Squamous cell carcinoma of the stomach. 61
26012332 2014
28
A rare case of primary squamous cell carcinoma of the stomach and a review of the 56 cases reported in Japan. 61
24765539 2014
29
Synchronous double cancers of colonic large cell neuroendocrine carcinoma and gastric squamous-cell carcinoma: a case report and review of literature. 61
25197393 2014
30
Role of genetic variants of deleted in colorectal carcinoma (DCC) polymorphisms and esophageal and gastric cancers risk in Kashmir Valley and meta-analysis. 61
23765761 2013
31
Primary squamous cell carcinoma of the stomach: a rare entity. 61
23709554 2013
32
The clinicopathologic and prognostic analysis of adenosquamous and squamous cell carcinoma of the stomach. 61
23635572 2013
33
Primary squamous cell carcinoma in the gastric remnant. 61
22350299 2012
34
A case of two primary gastric malignancies: adenocarcinoma and squamous cell carcinoma of the stomach. 61
21802677 2012
35
[Diagnostic assessment of peritoneal fluid cytology in horses with abdominal neoplasia]. 61
22526721 2012
36
Primary squamous cell carcinoma of the stomach in a 68-years-old man. 61
21166967 2011
37
Immunohistochemical characterization of a squamous cell carcinoma in a harbour porpoise (Phocoena phocoena) from German waters. 61
20096418 2010
38
Primary squamous cell carcinoma of the stomach: a case report. 61
19960279 2010
39
[Histological complete response in a case of primary squamous cell carcinoma of the stomach treated by chemotherapy with docetaxel and cisplatin plus 5-fluorouracil]. 61
20154491 2010
40
Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia. 61
21113875 2010
41
[A case of the gastric squamous cell carcinoma recurred in the kidney 5 years and 4 months after curative resection]. 61
20037413 2009
42
Primary squamous cell carcinoma of the stomach with paraneoplastic leukocytosis: a case report and review of literature. 61
19467693 2009
43
Primary squamous cell carcinoma of the stomach that developed with Menetrier's disease. 61
17443414 2007
44
Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma. 61
16810741 2006
45
[Clinicopathological features and differences of p53 and Ki-67 expression in adenosquamous and squamous cell carcinomas of the stomach]. 61
16809949 2006
46
Squamous cell carcinoma of stomach. 61
17089621 2006
47
Primary squamous cell carcinoma of the stomach: a case report. 61
16459645 2005
48
Primary squamous cell carcinoma of the stomach: a case report with immunohistochemical and molecular biologic studies. 61
15966243 2005
49
Synchronous squamous cell carcinoma of the stomach, the lung and the skin. 61
15249720 2004
50
Exophytic primary squamous cell carcinoma of the stomach. 61
15065010 2004

Variations for Gastric Squamous Cell Carcinoma

Cosmic variations for Gastric Squamous Cell Carcinoma:

9 (show top 50) (show all 55)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87899067 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
2 COSM88054450 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 9
3 COSM88395179 NOTCH2 stomach,NS,carcinoma,squamous cell carcinoma c.2898C>G p.D966E 1:119941609-119941609 9
4 COSM87657983 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 9
5 COSM87657993 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 9
6 COSM87804028 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
7 COSM112988906 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 9
8 COSM112988842 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
9 COSM91331222 stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 9
10 COSM91331151 stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
11 COSM122874337 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
12 COSM101967270 stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
13 COSM112389930 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
14 COSM122272106 stomach,NS,carcinoma,squamous cell carcinoma c.442A>G p.R148G 17:7673782-7673782 9
15 COSM144422902 stomach,NS,carcinoma,squamous cell carcinoma c.976C>T p.H326Y 17:7670616-7670616 9
16 COSM121876918 stomach,NS,carcinoma,squamous cell carcinoma c.442A>G p.R148G 17:7673782-7673782 9
17 COSM144310794 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
18 COSM105621035 stomach,NS,carcinoma,squamous cell carcinoma c.782+399A>G p.? 17:7673782-7673782 9
19 COSM101951599 stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
20 COSM105721452 stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 9
21 COSM143271103 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
22 COSM106188079 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
23 COSM143944515 stomach,NS,carcinoma,squamous cell carcinoma c.361A>G p.R121G 17:7673782-7673782 9
24 COSM105721382 stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 9
25 COSM134990131 stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
26 COSM142837846 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
27 COSM144131149 stomach,NS,carcinoma,squamous cell carcinoma c.1060C>T p.H354Y 17:7670616-7670616 9
28 COSM111894158 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 9
29 COSM144651833 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
30 COSM122021881 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
31 COSM142953005 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
32 COSM144067731 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
33 COSM101967324 stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 9
34 COSM143157273 stomach,NS,carcinoma,squamous cell carcinoma c.361A>G p.R121G 17:7673782-7673782 9
35 COSM134614942 stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
36 COSM101951669 stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 9
37 COSM144797256 stomach,NS,carcinoma,squamous cell carcinoma c.*200C>T p.? 17:7670616-7670616 9
38 COSM93320759 stomach,NS,carcinoma,squamous cell carcinoma c.993+2919C>T p.? 17:7670616-7670616 9
39 COSM143501622 stomach,NS,carcinoma,squamous cell carcinoma c.*112C>T p.? 17:7670616-7670616 9
40 COSM91859734 stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
41 COSM145018343 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
42 COSM142695528 stomach,NS,carcinoma,squamous cell carcinoma c.976C>T p.H326Y 17:7670616-7670616 9
43 COSM145143529 stomach,NS,carcinoma,squamous cell carcinoma c.976C>T p.H326Y 17:7670616-7670616 9
44 COSM144199360 stomach,NS,carcinoma,squamous cell carcinoma c.616C>T p.H206Y 17:7670616-7670616 9
45 COSM105773940 stomach,NS,carcinoma,squamous cell carcinoma c.782+3565C>T p.? 17:7670616-7670616 9
46 COSM144014053 stomach,NS,carcinoma,squamous cell carcinoma c.805A>G p.R269G 17:7673782-7673782 9
47 COSM106053774 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
48 COSM112254260 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
49 COSM142560887 stomach,NS,carcinoma,squamous cell carcinoma c.721A>G p.R241G 17:7673782-7673782 9
50 COSM122401099 stomach,NS,carcinoma,squamous cell carcinoma c.697C>T p.H233Y 17:7670616-7670616 9

Expression for Gastric Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gastric Squamous Cell Carcinoma.

Pathways for Gastric Squamous Cell Carcinoma

Pathways related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 KRT7 KRT5 KRT10
2
Show member pathways
11.25 KRT7 KRT5 KRT10

GO Terms for Gastric Squamous Cell Carcinoma

Cellular components related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT7 KRT5 KRT10
2 extracellular exosome GO:0070062 9.1 UPK3A SERPINA3 KRT7 KRT5 KRT10 IST1

Biological processes related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT7 KRT5 KRT10
2 cornification GO:0070268 8.8 KRT7 KRT5 KRT10

Sources for Gastric Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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