MCID: GST028
MIFTS: 37

Gastric Squamous Cell Carcinoma

Categories: Gastrointestinal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Gastric Squamous Cell Carcinoma

MalaCards integrated aliases for Gastric Squamous Cell Carcinoma:

Name: Gastric Squamous Cell Carcinoma 12 59 15 73
Squamous Cell Carcinoma of the Stomach 59
Squamous Cell Carcinoma of Stomach 12

Characteristics:

Orphanet epidemiological data:

59
squamous cell carcinoma of the stomach
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide);

Classifications:



External Ids:

Disease Ontology 12 DOID:5516
NCIt 50 C5475
Orphanet 59 ORPHA418959
ICD10 via Orphanet 34 C16.0 C16.1 C16.2 more
UMLS 73 C1333789

Summaries for Gastric Squamous Cell Carcinoma

MalaCards based summary : Gastric Squamous Cell Carcinoma, also known as squamous cell carcinoma of the stomach, is related to large cell neuroendocrine carcinoma and large cell acanthoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Squamous Cell Carcinoma is DCC (DCC Netrin 1 Receptor), and among its related pathways/superpathways are Pathways in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Oxaliplatin and Pembrolizumab have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotype is craniofacial.

Related Diseases for Gastric Squamous Cell Carcinoma

Diseases related to Gastric Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 27.6 CHGA ENO2 NCAM1 SYP
2 large cell acanthoma 10.7 KRT10 KRT5
3 epidermolysis bullosa simplex with mottled pigmentation 10.7 KRT10 KRT5
4 breast squamous cell carcinoma 10.7 KRT10 KRT5
5 nodular hidradenoma 10.7 KITLG KRT10
6 malignant biphasic mesothelioma 10.7 KRT10 KRT5
7 epidermolysis bullosa simplex, dowling-meara type 10.7 KRT10 KRT5
8 cutaneous solitary mastocytoma 10.6 KITLG SERPINA3
9 lipoadenoma 10.6 KRT5 SERPINA3
10 pallister-hall syndrome 10.5 GLI1 SHH
11 intraneural perineurioma 10.5 KRT10 KRT5
12 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.5 GLI1 SHH
13 dowling-degos disease 1 10.5 KITLG KRT5
14 keratosis, seborrheic 10.3 KRT10 KRT5
15 cystadenofibroma 10.3 KRT5 NCAM1
16 keratocystic odontogenic tumor 10.3 GLI1 SHH
17 central nervous system tuberculosis 10.3 GLI1 SHH
18 atypical choroid plexus papilloma 10.3 KRT5 SYP
19 squamous cell carcinoma 10.3
20 lung combined type small cell carcinoma 10.2 NCAM1 SYP
21 adenoma of the pancreas 10.2 CHGA SYP
22 peritoneal serous adenocarcinoma 10.2 CHGA SYP
23 cellular ependymoma 10.2 CHGA SYP
24 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
25 gastrointestinal neuroendocrine tumor 10.2 CHGA SYP
26 epithelioid leiomyosarcoma 10.2 ENO2 SERPINA3
27 chordoid meningioma 10.2 CHGA SYP
28 hypoganglionosis 10.2 NCAM1 SYP
29 pancreatic endocrine carcinoma 10.2 NCAM1 SYP
30 supratentorial primitive neuroectodermal tumor 10.2 NCAM1 SYP
31 mediastinal cancer 10.2 NCAM1 SYP
32 pulmonary sclerosing hemangioma 10.1 CHGA SYP
33 pancreatoblastoma 10.1 CHGA SYP
34 pulmonary blastoma 10.1 CHGA SYP
35 malignant skin fibrous histiocytoma 10.1 CHGA NCAM1
36 ureter, cancer of 10.1 CHGA SYP
37 tanycytic ependymoma 10.1 CHGA SYP
38 non-functioning pancreatic endocrine tumor 10.1 CHGA SYP
39 cystitis cystica 10.1 KRT5 SYP
40 pleomorphic xanthoastrocytoma 10.1 CHGA SYP
41 malignant dermis tumor 10.1 CHGA NCAM1
42 spermatocele 10.1 NCAM1 SYP
43 granular cell tumor 10.1 ENO2 SERPINA3
44 binswanger's disease 10.1 CHGA SYP
45 lymphoepithelioma-like carcinoma 10.0 ENO2 KRT5
46 basal cell carcinoma 10.0 GLI1 KRT10 SHH
47 multiple mucosal neuroma 10.0 ENO2 NCAM1
48 intracranial primitive neuroectodermal tumor 10.0 CHGA ENO2
49 lung meningioma 10.0 ENO2 NCAM1
50 adrenal rest tumor 10.0 NCAM1 SYP

Graphical network of the top 20 diseases related to Gastric Squamous Cell Carcinoma:



Diseases related to Gastric Squamous Cell Carcinoma

Symptoms & Phenotypes for Gastric Squamous Cell Carcinoma

UMLS symptoms related to Gastric Squamous Cell Carcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.02 GLI1 KITLG KRT5 SHH ENO2

Drugs & Therapeutics for Gastric Squamous Cell Carcinoma

Drugs for Gastric Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
2
Pembrolizumab Approved Phase 2 1374853-91-4
3
nivolumab Approved Phase 2 946414-94-4
4
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
6 10-deazaaminopterin Phase 2
7 Folic Acid Antagonists Phase 2
8 Vitamin B Complex Phase 2
9 Antibodies Phase 2
10 Immunoglobulins Phase 2
11 Antibodies, Monoclonal Phase 2
12 Folate Nutraceutical Phase 2
13 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer Completed NCT01178944 Phase 2 Oxaliplatin;Pralatrexate
2 Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer Recruiting NCT02830594 Phase 2
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Gastric Squamous Cell Carcinoma

Genetic Tests for Gastric Squamous Cell Carcinoma

Anatomical Context for Gastric Squamous Cell Carcinoma

MalaCards organs/tissues related to Gastric Squamous Cell Carcinoma:

41
Colon

Publications for Gastric Squamous Cell Carcinoma

Articles related to Gastric Squamous Cell Carcinoma:

# Title Authors Year
1
Primary Gastric Squamous Cell Carcinoma. ( 29850384 )
2018
2
Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report. ( 29390350 )
2017
3
The clinicopathological features and prognostic factors of gastric squamous cell carcinoma. ( 27559983 )
2016
4
Clinicopathological Characteristics, Treatment, and Prognosis of 21 Patients with Primary Gastric Squamous Cell Carcinoma. ( 27478431 )
2016
5
Synchronous double cancers of colonic large cell neuroendocrine carcinoma and gastric squamous-cell carcinoma: a case report and review of literature. ( 25197393 )
2014
6
Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia. ( 21113875 )
2010
7
Gastric squamous cell carcinoma in three llamas. ( 9087939 )
1997
8
Gastric squamous cell carcinoma in three horses. ( 9412445 )
1997
9
Gastric squamous cell carcinoma and fascioliasis in a llama. ( 3402219 )
1988
10
Gastric squamous cell carcinoma in a dog. ( 7361385 )
1980

Variations for Gastric Squamous Cell Carcinoma

Cosmic variations for Gastric Squamous Cell Carcinoma:

9
(show all 16)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM11123 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 10
2 COSM6904034 TP53 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 10
3 COSM6904040 NOTCH2 stomach,NS,carcinoma,squamous cell carcinoma c.2898C>G p.D966E 1:119941609-119941609 10
4 COSM6904039 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 10
5 COSM6904037 NOTCH1 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 10
6 COSM532 KRAS stomach,NS,carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 10
7 COSM498 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 10
8 COSM487 HRAS stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 10
9 COSM562339 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 10
10 COSM6904038 stomach,NS,carcinoma,squamous cell carcinoma c.2055C>G p.N685K 9:136514662-136514662 10
11 COSM99664 stomach,NS,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 11:533874-533874 10
12 COSM3448605 stomach,NS,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 10
13 COSM1649339 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 10
14 COSM6904035 stomach,NS,carcinoma,squamous cell carcinoma c.1093C>T p.H365Y 17:7670616-7670616 10
15 COSM3378442 stomach,NS,carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 10
16 COSM6904036 stomach,NS,carcinoma,squamous cell carcinoma c.2213A>G p.K738R 9:136513532-136513532 10

Expression for Gastric Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gastric Squamous Cell Carcinoma.

Pathways for Gastric Squamous Cell Carcinoma

GO Terms for Gastric Squamous Cell Carcinoma

Cellular components related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CHGA ENO2 KITLG KRT10 SERPINA3 SHH

Biological processes related to Gastric Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.5 DCC NCAM1 SHH
2 positive regulation of DNA replication GO:0045740 9.46 GLI1 KITLG
3 neural crest cell migration GO:0001755 9.43 KITLG SHH
4 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.4 DCC KITLG
5 positive regulation of smoothened signaling pathway GO:0045880 9.37 GLI1 SHH
6 prostate gland development GO:0030850 9.26 GLI1 SHH
7 digestive tract morphogenesis GO:0048546 9.16 GLI1 SHH
8 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 8.96 GLI1 SHH
9 ventral midline development GO:0007418 8.62 GLI1 SHH

Sources for Gastric Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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