MCID: GST023
MIFTS: 57

Gastric Ulcer

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastric Ulcer

MalaCards integrated aliases for Gastric Ulcer:

Name: Gastric Ulcer 12 55 15 73
Acute Gastric Ulcer Without Mention of Hemorrhage or Perforation, Without Mention of Obstruction 12
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation but with Obstruction 12
Chronic Gastric Ulcer Without Mention of Hemorrhage or Perforation, with Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation, Without Mention of Obstruction 12
Acute Gastric Ulcer Without Hemorrhage, Without Perforation and Without Obstruction 12
Acute Gastric Ulcer with Hemorrhage and with Perforation but Without Obstruction 12
Acute Gastric Ulcer with Hemorrhage, with Perforation and with Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation, with Obstruction 12
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastric Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastric Ulcer with Perforation, with Obstruction 12
Acute Gastric Ulcer with Hemorrhage, with Obstruction 12
Acute Gastric Ulcer with Haemorrhage and Perforation 12
Acute Gastric Ulcer with Perforation and Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation 12
Acute Gastric Ulcer with Perforation 12
Bleeding Acute Gastric Ulcer 12
Stomach Ulcer 44

Classifications:



External Ids:

Disease Ontology 12 DOID:10808
ICD9CM 35 531
MeSH 44 D013276
NCIt 50 C3388
SNOMED-CT 68 6034002
UMLS 73 C0038358

Summaries for Gastric Ulcer

MalaCards based summary : Gastric Ulcer, also known as acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction, is related to peptic ulcer disease and helicobacter pylori infection. An important gene associated with Gastric Ulcer is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Amoxicillin and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and bone, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Gastric Ulcer

Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 31.7 PTGS2 IL1RN IL1B HRH2 GAST CYP2C19
2 helicobacter pylori infection 30.5 IL1B GAST CYP2C19 CXCL8
3 bile reflux 30.4 TFF1 PTGS2
4 gastritis 30.4 PTGS2 IL1RN IL1B HRH2 GAST CXCL8
5 atrophic gastritis 30.1 IL1RN IL1B GAST CXCL8
6 peptic esophagitis 30.0 CXCL8 CYP2C19 HRH2 IL1B
7 arthritis 29.9 PTGS2 IL1RN IL1B CXCL8
8 esophagitis 29.9 CXCL8 CYP2C19 HRH2 IL1B PTGS2
9 duodenal ulcer 29.9 IL1RN IL1B HRH2 GAST CYP2C19 CXCL8
10 colitis 29.9 IL1B CXCL8 PTGS2
11 rheumatic disease 29.8 PTGS2 PTGS1 IL1B
12 active peptic ulcer disease 29.6 PTGS2 PTGS1 HRH2
13 gastric cancer 29.3 EGF GAST HGF IL1B IL1RN MMP7
14 rheumatoid arthritis 29.2 PTGS2 IL1RN IL1B CXCL8
15 gastroesophageal reflux 29.1 PTGS2 PTGS1 IL1B HRH2 GAST CYP2C19
16 dyspepsia 29.0 CXCL8 CYP2C19 HRH2 PTGS1 PTGS2
17 gastric adenocarcinoma 28.8 CXCL8 EGF GAST IL1B IL1RN PTGS2
18 chronic erosive gastritis 11.3
19 alcoholic gastritis 10.2 PTGS2 IL1B
20 acute generalized exanthematous pustulosis 10.2 PTGS2 CXCL8
21 exudative glomerulonephritis 10.2 IL1B CXCL8
22 leukoregulin 10.2 PTGS2 CXCL8
23 recurrent corneal erosion 10.2 IL1B CXCL8
24 vulvar vestibulitis syndrome 10.2 IL1RN IL1B
25 bagassosis 10.2 IL1B CXCL8
26 gastric cancer, hereditary diffuse 10.2 IL1RN IL1B
27 schnitzler syndrome 10.2 IL1RN IL1B
28 pancreatic cholera 10.2 HRH2 GAST
29 haemophilus influenzae 10.2 IL1B CXCL8
30 funisitis 10.2 IL1B CXCL8
31 peptic ulcer perforation 10.2 PTGS2 HRH2 GAST
32 osteosclerotic myeloma 10.2 IL1RN IL1B
33 chronic ulcer of skin 10.2 FGF2 EGF
34 aspirin resistance 10.2 PTGS2 PTGS1
35 esophageal disease 10.1 PTGS2 HRH2 GAST
36 opisthorchiasis 10.1 CXCL8 IL1B
37 duodenogastric reflux 10.1
38 pouchitis 10.1 IL1RN CXCL8
39 burns 10.1 IL1B HGF
40 ascaris lumbricoides infection 10.1 IL1B CXCL8
41 laryngitis 10.1 IL1B HRH2 FGF2
42 crohn's colitis 10.1 IL1B CXCL8
43 meningococcemia 10.1 IL1RN IL1B
44 chronic myocardial ischemia 10.1 HGF FGF2
45 endometrial disease 10.1 PTGS2 IL1B CXCL8
46 pharyngitis 10.1 PTGS2 IL1B CXCL8
47 cystitis 10.1 PTGS2 EGF CXCL8
48 dental pulp disease 10.1 IL1B CXCL8
49 ischemia 10.1
50 pancreatitis 10.1

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to Gastric Ulcer

Symptoms & Phenotypes for Gastric Ulcer

MGI Mouse Phenotypes related to Gastric Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 EGF GAST HRH2 MMP7 PTGS1 PTGS2
2 homeostasis/metabolism MP:0005376 9.61 FGF2 GAST HRH2 IL1B IL1RN MMP7
3 neoplasm MP:0002006 9.17 FGF2 GAST IL1B MMP7 PTGS1 PTGS2

Drugs & Therapeutics for Gastric Ulcer

Drugs for Gastric Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
2
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1 103577-45-3 3883
3
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
4
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1 103577-45-3, 138530-94-6 9578005
5
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 117976-89-3 5029
6
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
8
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
9
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
10
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
11
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 73590-58-6 4594
12
Pantoprazole Approved Phase 4,Phase 3,Not Applicable 102625-70-7 4679
13
Tetracycline Approved, Vet_approved Phase 4,Not Applicable 60-54-8 5353990
14
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Colchicine Approved Phase 4 64-86-8 6167 2833
17
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
18
Iron Approved Phase 4,Phase 2 7439-89-6 23925
19
Deferasirox Approved, Investigational Phase 4,Phase 2 201530-41-8 5493381
20
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
21
Famotidine Approved Phase 4,Phase 3 76824-35-6 3325
22
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 51-45-6, 75614-87-8 774
23
Ranitidine Approved Phase 4,Phase 3 66357-35-5, 66357-59-3 3001055
24
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
25
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565
26
Loperamide Approved Phase 4 53179-11-6 3955
27
Simethicone Approved Phase 4 8050-81-5
28
Ecabet Investigational Phase 4 86408-72-2, 33159-27-2 65781
29
Furazolidone Experimental, Vet_approved Phase 4,Not Applicable 67-45-8 5323714 3435
30 Rebamipide Investigational Phase 4,Phase 3,Phase 2,Not Applicable 90098-04-7
31 Benzimidazole Experimental, Investigational Phase 4 51-17-2
32 Antacids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
37 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Proton Pump Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
41 Antiparasitic Agents Phase 4,Phase 2,Phase 3
42 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Antipyretics Phase 4,Phase 3,Phase 2,Not Applicable
50 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 151)
# Name Status NCT ID Phase Drugs
1 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
2 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
3 The Safety and Efficacy of Albis®: The Prevention of Aspirin-induced Gastrointestinal Ulcers in Patients Unknown status NCT01397240 Phase 4 Albis Tab;Placebo
4 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
5 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
6 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
7 Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection Unknown status NCT01308177 Phase 4 Ecabet
8 Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy Completed NCT00272467 Phase 4 Rebamipide;Omeprazole
9 Post-Marketing Clinical Study of Rebamipide in Patients With Gastric Ulcer Completed NCT00233389 Phase 4 Rebamipide
10 A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium Completed NCT00125736 Phase 4 E0671;rabeprazole sodium;E0671 placebo
11 Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer Completed NCT01190657 Phase 4 Selbex;Selbex
12 An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium Completed NCT00428701 Phase 4 Esomeprazole Sodium
13 Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer Completed NCT00239551 Phase 4 Prevacid
14 Opioid-induced Hyperalgesia After Remifentanil Infusion Completed NCT01702389 Phase 4 Remifentanil
15 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
16 Colchicine Or Naproxen Treatment for ACute gouT Completed NCT01994226 Phase 4 Low-dose colchicine;Naproxen 750 mg/250 mg
17 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
18 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
19 Effect of ALBIS on Gastroduodenal Mucosal Injury in Patients Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention Recruiting NCT02175186 Phase 4 ALBIS;Placebo
20 Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy Recruiting NCT03609892 Phase 4 Berberine;Amoxicillin;Esomeprazole;Bismuth;Tetracycline;Furazolidone;Esomeprazole;Bismuth
21 Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis Recruiting NCT03372083 Phase 4 Deferasirox
22 Comparison of Misoprostol Ripening Efficacy With Dilapan Recruiting NCT03670836 Phase 4 Misoprostol
23 Helicobacter Eradication Aspirin Trial Active, not recruiting NCT01506986 Phase 4 Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg;Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
24 Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft Not yet recruiting NCT03038009 Phase 4 Pantoprazole
25 Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis Terminated NCT00839488 Phase 4 pantoprazole 40 mg iv;famotidine 20 mg iv
26 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
27 Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation Terminated NCT02217982 Phase 4 Simethicone;Loperamide
28 A Study To Assess The Efficacy And Safety Of Bismuth Tripotassium Dicitrate (De-Nol) In Combination With Pantoprazole And Pantoprazole Monotherapy In Treatment Of Subjects With Nonsteroidal Anti-Inflammatory Drugs (NSAID)-Induced Gastropathy Terminated NCT02788123 Phase 4 bismuth tripotassium dicitrate;pantoprazole
29 Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1% Unknown status NCT02068859 Phase 3 Diclofenac Cream 8%;Diclofenac Gel 1%
30 Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection Unknown status NCT00197418 Phase 2, Phase 3 rabeprazole, amoxicillin, clarithromycin, metronidazole
31 Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori Unknown status NCT00149084 Phase 3 Lansoprazole, clarithromycin, amoxicillin
32 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00960869 Phase 3 PA32540;EC-Aspirin 325 mg
33 A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00961350 Phase 3 PA32540;EC Aspirin 325
34 Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric Ulcer Completed NCT00401752 Phase 3 Esomeprazole;Ranitidine
35 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT01129011 Phase 3 PN400 (VIMOVO);Naproxen
36 Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Gastric Ulcer Completed NCT01452711 Phase 3 TAK-438;Placebo;Lansoprazole;Placebo
37 Mucosta in Gastric Ulcer Treatment, Effectiveness and Safety Evaluation Completed NCT01150162 Phase 3 Rebamipide and Omeprazole;Omeprazole
38 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT00527787 Phase 3 PN400 (VIMOVO);Naproxen
39 Healing Effects of Autologous Platelet Rich Plasma on Gastric Ulcer Caused by Endoscopic Submucosal Dissection Completed NCT03220334 Phase 3 Platelet rich plasma;Normal saline
40 A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued Completed NCT00633672 Phase 3 Esomeprazole;Ranitidine;Esomeprazole
41 Prevention of Gastric Ulcers Completed NCT00629512 Phase 3 Esomeprazole;Esomeprazole;Placebo
42 A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only Completed NCT00633412 Phase 3 Esomeprazole;Ranitidine;Esomeprazole
43 Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn® Completed NCT01063920 Phase 2, Phase 3 LT-NS001;Naprosyn®
44 Study to Evaluate the Long-Term Safety of PA32540 in Subjects Who Are at Risk for Developing Aspirin-Associated Gastric Ulcers Completed NCT00995410 Phase 3 PA32540
45 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers. Completed NCT00367211 Phase 3 PN 200 tablets (500 mg naproxen and 20 mg omeprazole);Naproxen 500 mg tablets (PN 200 minus omeprazole)
46 Ulcer Prevention II Completed NCT00629928 Phase 3 Esomeprazole;Esomeprazole;Placebo
47 Efficacy and Safety of Lansoprazole on Gastric and Duodenal Ulcers in Patients Taking Nonsteroidal Anti-Inflammatory Drugs Completed NCT00787254 Phase 3 Lansoprazole;Gefarnate
48 Effect of Selective COX-2 Inhibition on Ulcer Healing Completed NCT00153673 Phase 3 celecoxib;Dologesics
49 A 12-month, Phase 3, Open-label, Multi-center Study to Evaluate the Long-term Safety of PN400 (VIMOVO) Completed NCT00527904 Phase 3 PN400 (VIMOVO);PN 400 (VIMOVO)
50 Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA) Completed NCT00441727 Phase 3 Esomeprazole 40 mg;Esomeprazole 20 mg;Placebo

Search NIH Clinical Center for Gastric Ulcer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: stomach ulcer

Genetic Tests for Gastric Ulcer

Anatomical Context for Gastric Ulcer

MalaCards organs/tissues related to Gastric Ulcer:

41
Endothelial, Liver, Bone, Heart, Pancreas, Skin, Testes

Publications for Gastric Ulcer

Articles related to Gastric Ulcer:

(show top 50) (show all 1076)
# Title Authors Year
1
Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile. ( 29626382 )
2018
2
Accelerated gastric ulcer healing in thyroxine-treated rats; roles of gastric acid, mucus and inflammatory response. ( 29406826 )
2018
3
Prophylactic therapy with omeprazole for prevention of equine gastric ulcer syndrome (EGUS) in horses in active training: A meta-analysis. ( 29665126 )
2018
4
Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat. ( 29702486 )
2018
5
Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats. ( 29944876 )
2018
6
Hemorrhagic Stress-induced Gastric Ulcer in a Healthy Toddler. ( 29780141 )
2018
7
Therapeutic Endoscopy in Combination with Quadruple Therapy in Treating Bleeding Caused by Gastric Ulcer. ( 29643870 )
2018
8
Protective effect of bovine milk against HCl and ethanol-induced gastric ulcer in mice. ( 29477532 )
2018
9
Gastric Ulcer Bleeding Due to Left Gastric Artery Pseudoaneurysm. ( 29899435 )
2018
10
Pharmacogenetic testing by polymorphic markers 681G>A and 636G>A CYP2C19 gene in patients with acute coronary syndrome and gastric ulcer in the Republic of Sakha (Yakutia). ( 29738309 )
2018
11
Anti-<i>Helicobacter pylori</i> and Anti-Inflammatory Effects and Constituent Analysis of Modified Xiaochaihutang for the Treatment of Chronic Gastritis and Gastric Ulcer. ( 29681980 )
2018
12
Combination therapy with polydeoxyribonucleotide and proton pump inhibitor enhances therapeutic effectiveness for gastric ulcer in rats. ( 29665355 )
2018
13
Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models. ( 29136948 )
2018
14
Gastric ulcer related with gastrostomy feeding tube: Description of 3 cases and review of literature. ( 29366827 )
2018
15
Diagnostic accuracy of blood sucrose as a screening test for equine gastric ulcer syndrome (EGUS) in weanling foals. ( 29653546 )
2018
16
Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities. ( 29455967 )
2018
17
Antioxidant and anti-inflammatory activities of alpha lipoic acid protect against indomethacin-induced gastric ulcer in rats. ( 29486337 )
2018
18
Protective role of I^-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. ( 29433672 )
2018
19
Porcine stomachs with and without gastric ulcer differ in Lactobacillus load and strain characteristics. ( 29554439 )
2018
20
Prophylactic efficacy of patchoulene epoxide against ethanol-induced gastric ulcer in rats: Influence on oxidative stress, inflammation and apoptosis. ( 29339218 )
2018
21
Nonhealing Gastric Ulcer Due to Mesh Eroding Through GastricA Wall. ( 29574032 )
2018
22
A Rare Case of Systemic Lupus Erythematosus with Gastric Ulcer and Acute Pancreatitis: A Case Report and Literature Review. ( 30116433 )
2018
23
Nonhealing gastric ulcer: progression from gastric adenoma to early gastric cancer over 9 years. ( 30176228 )
2018
24
Role of gastroscopic biopsy of gastric ulcer margins and healed sites in the diagnosis of early gastric cancer: A clinical controlled study of 513 cases. ( 30250534 )
2018
25
Protective effect of oleane-12-en-3β-ol-28-oic acid 3β-D-glucopyranoside in ethanol induced gastric ulcer by enhancing the prostaglandin E2 level. ( 28942137 )
2018
26
1-Deoxynojirimycin (DNJ) Ameliorates Indomethacin-Induced Gastric Ulcer in Mice by Affecting NF-kappaB Signaling Pathway. ( 29725297 )
2018
27
Cytomegalovirus associated with gastric ulcer: case report and literature review. ( 30007786 )
2018
28
Nivolumab-Induced Hemophilia A Presenting as Gastric Ulcer Bleeding in a Patient With NSCLC. ( 30017828 )
2018
29
Gastroprotective and anti-ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival mechanisms. ( 30024074 )
2018
30
Splenic artery pseudoaneurysm with splenic infarction induced by a benign gastric ulcer: A case report. ( 30024561 )
2018
31
The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior. ( 30073231 )
2018
32
Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats. ( 30081206 )
2018
33
Neuroendocrine Tumor Presenting as a Large Gastric Ulcer. ( 30099100 )
2018
34
Antiulcer Effect of Honey in Nonsteroidal Anti-Inflammatory Drugs Induced Gastric Ulcer Model in Rats: A Systematic Review. ( 30105063 )
2018
35
Gastric Ulcer from the Pressure of a Gastrostomy Tube: A Rare Cause of Upper Gastrointestinal Bleeding. ( 30112259 )
2018
36
Pharmacokinetics of costunolide and dehydrocostuslactone after oral administration of Radix aucklandiae extract in normal and gastric ulcer rats. ( 30130142 )
2018
37
Medial arcuate ligament syndrome as an infrequent cause of refractory gastric ulcer. ( 30146359 )
2018
38
Gastric ulcer induced changes in substance P and Nk1, Nk2, Nk3 receptors expression in different stomach localizations with regard to intrinsic neuronal system. ( 30155561 )
2018
39
Effect of ilaprazole on the healing of endoscopic submucosal dissection-induced gastric ulcer: randomized-controlled, multicenter study. ( 30167954 )
2018
40
Randomized Controlled Trial Comparing the Effects of Vonoprazan Plus Rebamipide and Esomeprazole Plus Rebamipide on Gastric Ulcer Healing Induced by Endoscopic Submucosal Dissection. ( 30210115 )
2018
41
Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats. ( 30344421 )
2018
42
Antiulcer effects of Zataria multiflora Boiss. on indomethacin-induced gastric ulcer in rats. ( 30345228 )
2018
43
Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. ( 30396089 )
2018
44
Protective Effects of Dioscorea batatas Flesh and Peel Extracts against Ethanol-Induced Gastric Ulcer in Mice. ( 30400615 )
2018
45
Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcer in Sprague-Dawley rats. ( 30426792 )
2018
46
Protective Effect of Silkworm Pupa Oil on Hydrochloric Acid/Ethanol-Induced Gastric Ulcer. ( 30479041 )
2018
47
Antichronic Gastric Ulcer Effect of Zinc-Baicalin Complex on the Acetic Acid-Induced Chronic Gastric Ulcer Rat Model. ( 30510570 )
2018
48
Pulicaria crispa mitigates gastric ulcer induced by ethanol in rats: Role of treatment and auto healing. ( 30512969 )
2018
49
Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway. ( 30523551 )
2018
50
Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-α, NF-ĸB, and COX-2 levels, and upregulation of TFF-2 levels. ( 30530291 )
2018

Variations for Gastric Ulcer

Expression for Gastric Ulcer

Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for Gastric Ulcer

Pathways related to Gastric Ulcer according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 CXCL8 EGF FGF2 HGF IL1B IL1RN
2 12.64 CXCL8 EGF FGF2 HGF PTGS2
3 12.61 EGF FGF2 HGF IL1B
4
Show member pathways
12.55 EGF FGF2 HGF IL1B
5 12.4 IL1B IL1RN PTGS1 PTGS2
6
Show member pathways
12.16 CXCL8 FGF2 IL1B PTGS2
7
Show member pathways
12.14 EGF HRH2 PTGS2 TFF1
8
Show member pathways
12.1 CXCL8 FGF2 HGF IL1B
9 12.05 EGF MMP7 PTGS2
10
Show member pathways
12.04 CYP2C19 PTGS1 PTGS2
11 12.04 CXCL8 IL1B IL1RN
12
Show member pathways
11.98 CXCL8 IL1B IL1RN PTGS2
13 11.93 EGF FGF2 HGF
14 11.87 CXCL8 IL1B PTGS2
15
Show member pathways
11.85 CYP2C19 PTGS1 PTGS2
16 11.84 CYP2C19 PTGS1 PTGS2
17
Show member pathways
11.78 CXCL8 EGF FGF2 HGF IL1B
18 11.73 CXCL8 IL1B PTGS2
19 11.59 IL1B IL1RN PTGS2
20
Show member pathways
11.51 CXCL8 IL1B PTGS2
21 11.51 FGF2 HGF MMP7 PTGS2
22 11.41 CXCL8 FGF2 HGF IL1B PTGS2
23 11.34 CXCL8 HGF IL1B
24 11.31 EGF FGF2 HGF
25 11.15 CXCL8 IL1B IL1RN PTGS2
26 11.11 PTGS1 PTGS2
27
Show member pathways
11.09 PTGS1 PTGS2
28 11.08 CXCL8 HGF IL1B
29 11.03 PTGS1 PTGS2
30 11 PTGS1 PTGS2
31 10.85 HGF MMP7
32 10.85 CXCL8 EGF FGF2 HGF IL1B
33 10.82 CXCL8 EGF FGF2 HGF IL1B
34 10.79 PTGS1 PTGS2
35 10.78 CXCL8 PTGS1 PTGS2
36 10.19 GAST HRH2

GO Terms for Gastric Ulcer

Cellular components related to Gastric Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL8 EGF FGF2 GAST HGF IL1B
2 organelle membrane GO:0031090 9.33 CYP2C19 PTGS1 PTGS2
3 extracellular space GO:0005615 9.28 CXCL8 EGF FGF2 GAST HGF IL1B

Biological processes related to Gastric Ulcer according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CXCL8 HRH2 IL1B IL1RN
2 negative regulation of cell proliferation GO:0008285 9.9 CXCL8 IL1B PTGS2 TFF1
3 peptidyl-tyrosine phosphorylation GO:0018108 9.82 EGF FGF2 HGF
4 positive regulation of protein kinase B signaling GO:0051897 9.8 EGF FGF2 HGF
5 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL1B IL1RN
6 angiogenesis GO:0001525 9.78 CXCL8 EGF FGF2 PTGS2
7 inflammatory response GO:0006954 9.77 CXCL8 IL1B IL1RN PTGS1 PTGS2
8 MAPK cascade GO:0000165 9.76 EGF FGF2 HGF IL1B
9 phosphatidylinositol phosphorylation GO:0046854 9.74 EGF FGF2 HGF
10 neutrophil chemotaxis GO:0030593 9.71 CXCL8 IL1B IL1RN
11 cellular response to mechanical stimulus GO:0071260 9.7 IL1B MMP7 PTGS2
12 response to glucocorticoid GO:0051384 9.67 IL1B IL1RN PTGS2
13 positive regulation of mitotic nuclear division GO:0045840 9.64 EGF IL1B
14 positive regulation of vascular endothelial growth factor production GO:0010575 9.63 IL1B PTGS2
15 response to immobilization stress GO:0035902 9.62 IL1B TFF1
16 positive regulation of angiogenesis GO:0045766 9.62 CXCL8 FGF2 HGF IL1B
17 positive regulation of neutrophil chemotaxis GO:0090023 9.61 CXCL8 IL1B
18 prostaglandin metabolic process GO:0006693 9.61 PTGS1 PTGS2
19 response to vitamin D GO:0033280 9.59 IL1B PTGS2
20 prostaglandin biosynthetic process GO:0001516 9.58 PTGS1 PTGS2
21 positive regulation of DNA biosynthetic process GO:2000573 9.58 FGF2 HGF
22 ovulation GO:0030728 9.56 IL1B PTGS2
23 activation of MAPK activity GO:0000187 9.56 EGF FGF2 HGF IL1B
24 cyclooxygenase pathway GO:0019371 9.55 PTGS1 PTGS2
25 negative regulation of glutamate secretion GO:0014050 9.51 IL1B IL1RN
26 memory GO:0007613 9.46 HRH2 IL1B IL1RN PTGS2
27 positive regulation of fever generation GO:0031622 9.43 IL1B PTGS2
28 cytokine-mediated signaling pathway GO:0019221 9.43 CXCL8 FGF2 HGF IL1B IL1RN PTGS2
29 chronic inflammatory response to antigenic stimulus GO:0002439 9.4 IL1B IL1RN
30 regulation of signaling receptor activity GO:0010469 9.17 CXCL8 FGF2 GAST HGF IL1B IL1RN

Molecular functions related to Gastric Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.61 EGF FGF2 HGF
2 heme binding GO:0020037 9.58 CYP2C19 PTGS1 PTGS2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 EGF FGF2 HGF
4 cytokine activity GO:0005125 9.46 CXCL8 FGF2 IL1B IL1RN
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 EGF FGF2 HGF
6 interleukin-1 receptor binding GO:0005149 9.32 IL1B IL1RN
7 growth factor activity GO:0008083 9.26 EGF FGF2 HGF TFF1
8 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2

Sources for Gastric Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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