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MCID: GST023
MIFTS: 57

Gastric Ulcer

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Gastric Ulcer

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MalaCards integrated aliases for Gastric Ulcer:

Name: Gastric Ulcer 12 55 15 73
Acute Gastric Ulcer Without Mention of Hemorrhage or Perforation, Without Mention of Obstruction 12
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation but with Obstruction 12
Chronic Gastric Ulcer Without Mention of Hemorrhage or Perforation, with Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation, Without Mention of Obstruction 12
Acute Gastric Ulcer Without Hemorrhage, Without Perforation and Without Obstruction 12
Acute Gastric Ulcer with Hemorrhage and with Perforation but Without Obstruction 12
Acute Gastric Ulcer with Hemorrhage, with Perforation and with Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation, with Obstruction 12
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastric Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastric Ulcer with Perforation, with Obstruction 12
Acute Gastric Ulcer with Hemorrhage, with Obstruction 12
Acute Gastric Ulcer with Haemorrhage and Perforation 12
Acute Gastric Ulcer with Perforation and Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation 12
Acute Gastric Ulcer with Perforation 12
Bleeding Acute Gastric Ulcer 12
Stomach Ulcer 44

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Gastric Ulcer

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MalaCards based summary : Gastric Ulcer, also known as acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction, is related to bile reflux and peptic ulcer disease. An important gene associated with Gastric Ulcer is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Amoxicillin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and thyroid, and related phenotypes are digestive/alimentary and homeostasis/metabolism

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Related Diseases for Gastric Ulcer

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Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 bile reflux 30.8 PTGS2 TFF1
2 peptic ulcer disease 29.9 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
3 atrophic gastritis 29.7 CXCL8 GAST IL1B IL1RN
4 colitis 29.6 CXCL8 IL1B PTGS2
5 rheumatic disease 29.6 IL1B PTGS1 PTGS2
6 arthritis 29.6 CXCL8 IL1B IL1RN PTGS2
7 gastritis 29.4 CXCL8 GAST HRH2 IL1B IL1RN PTGS2
8 esophagitis 29.1 CXCL8 CYP2C19 HRH2 IL1B PTGS2
9 helicobacter pylori infection 29.0 CXCL8 CYP2C19 GAST IL1B IL1RN
10 gastric cancer 29.0 EGF GAST HGF IL1RN TFF1
11 peptic esophagitis 28.7 CXCL8 CYP2C19 HRH2 IL1B
12 duodenal ulcer 28.3 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
13 dyspepsia 27.9 CXCL8 CYP2C19 HRH2 PTGS1 PTGS2
14 gastric adenocarcinoma 27.7 CXCL8 GAST IL1B IL1RN PTGS2 TFF1
15 gastroesophageal reflux 27.0 CXCL8 CYP2C19 GAST HRH2 IL1B PTGS1
16 chronic erosive gastritis 11.1
17 acute generalized exanthematous pustulosis 10.6 CXCL8 PTGS2
18 leukoregulin 10.6 CXCL8 PTGS2
19 vulvar vestibulitis syndrome 10.6 IL1B IL1RN
20 pancreatic cholera 10.6 GAST HRH2
21 recurrent corneal erosion 10.6 CXCL8 IL1B
22 bagassosis 10.6 CXCL8 IL1B
23 gastric cancer, hereditary diffuse 10.6 IL1B IL1RN
24 schnitzler syndrome 10.6 IL1B IL1RN
25 cerebral artery occlusion 10.6 IL1B IL1RN
26 funisitis 10.5 CXCL8 IL1B
27 aspirin resistance 10.5 PTGS1 PTGS2
28 haemophilus influenzae 10.5 CXCL8 IL1B
29 opisthorchiasis 10.5 CXCL8 IL1B
30 burns 10.5 HGF IL1B
31 peptic ulcer perforation 10.5 GAST HRH2 PTGS2
32 pouchitis 10.5 CXCL8 IL1RN
33 crohn's colitis 10.5 CXCL8 IL1B
34 osteosclerotic myeloma 10.5 IL1B IL1RN
35 chronic myocardial ischemia 10.4 FGF2 HGF
36 vaginal disease 10.4 CXCL8 IL1B
37 laryngitis 10.4 FGF2 HRH2 IL1B
38 meningococcemia 10.4 IL1B IL1RN
39 functional gastric disease 10.4 HRH2 PTGS2
40 dental pulp disease 10.4 CXCL8 IL1B
41 zollinger-ellison syndrome 10.4 GAST HRH2
42 endometrial disease 10.3 CXCL8 IL1B PTGS2
43 pharyngitis 10.3 CXCL8 IL1B PTGS2
44 cystitis 10.3 CXCL8 EGF PTGS2
45 chronic leukemia 10.3 HGF PTGS2
46 vaginitis 10.3 CXCL8 IL1B
47 perinatal necrotizing enterocolitis 10.3 CXCL8 EGF IL1B
48 active peptic ulcer disease 10.3 HRH2 PTGS1 PTGS2
49 chronic laryngitis 10.3 CYP2C19 HRH2
50 adamantinoma of long bones 10.2 EGF FGF2 PTGS2

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to Gastric Ulcer
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Symptoms & Phenotypes for Gastric Ulcer

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MGI Mouse Phenotypes related to Gastric Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 EGF GAST HRH2 MMP7 PTGS1 PTGS2
2 homeostasis/metabolism MP:0005376 9.61 TFF1 FGF2 GAST HRH2 IL1B IL1RN
3 neoplasm MP:0002006 9.17 FGF2 GAST IL1B MMP7 PTGS1 PTGS2
Sources

Drugs & Therapeutics for Gastric Ulcer

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Drugs for Gastric Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
2
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
3
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1 138530-94-6, 103577-45-3 9578005
4
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1 103577-45-3 3883
5
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
6
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 117976-89-3 5029
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
8
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
9
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
10
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
11
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 73590-58-6 4594
12
Ecabet Approved, Investigational Phase 4 33159-27-2, 86408-72-2 65781
13
Pantoprazole Approved Phase 4,Phase 3,Not Applicable 102625-70-7 4679
14
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Colchicine Approved Phase 4 64-86-8 6167 2833
17
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
18
Famotidine Approved Phase 4,Phase 3 76824-35-6 3325
19
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 75614-87-8, 51-45-6 774
20
Ranitidine Approved Phase 4,Phase 3 66357-59-3, 66357-35-5 3001055
21
Deferasirox Approved, Investigational Phase 4,Phase 2 201530-41-8 5493381
22
Iron Approved Phase 4,Phase 2 7439-89-6 23925
23
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
24
Loperamide Approved Phase 4 53179-11-6 3955
25
Simethicone Approved Phase 4 8050-81-5
26 Benzimidazole Experimental, Investigational Phase 4 51-17-2
27 Rebamipide Investigational Phase 4,Phase 3,Phase 2,Not Applicable 90098-04-7
28 Antacids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Proton Pump Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Antiparasitic Agents Phase 4,Phase 2,Phase 3
37 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
38 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Antipyretics Phase 4,Phase 3,Phase 2,Not Applicable
43 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
49 HIV Protease Inhibitors Phase 4
50
protease inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 148)
# Name Status NCT ID Phase Drugs
1 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
2 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
3 The Safety and Efficacy of Albis®: The Prevention of Aspirin-induced Gastrointestinal Ulcers in Patients Unknown status NCT01397240 Phase 4 Albis Tab;Placebo
4 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
5 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
6 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
7 Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection Unknown status NCT01308177 Phase 4 Ecabet
8 Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy Completed NCT00272467 Phase 4 Rebamipide;Omeprazole
9 Post-Marketing Clinical Study of Rebamipide in Patients With Gastric Ulcer Completed NCT00233389 Phase 4 Rebamipide
10 A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium Completed NCT00125736 Phase 4 Teprenone
11 Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer Completed NCT01190657 Phase 4 Selbex;Selbex
12 An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium Completed NCT00428701 Phase 4 Esomeprazole Sodium
13 Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer Completed NCT00239551 Phase 4 Prevacid
14 Opioid-induced Hyperalgesia After Remifentanil Infusion Completed NCT01702389 Phase 4 Remifentanil
15 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
16 Colchicine Or Naproxen Treatment for ACute gouT Completed NCT01994226 Phase 4 Low-dose colchicine;Naproxen 750 mg/250 mg
17 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
18 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
19 Effect of ALBIS on Gastroduodenal Mucosal Injury in Patients Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention Recruiting NCT02175186 Phase 4 ALBIS;Placebo
20 Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis Recruiting NCT03372083 Phase 4 Deferasirox
21 Helicobacter Eradication Aspirin Trial Active, not recruiting NCT01506986 Phase 4 Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg;Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
22 Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft Not yet recruiting NCT03038009 Phase 4 Pantoprazole
23 Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis Terminated NCT00839488 Phase 4 pantoprazole 40 mg iv;famotidine 20 mg iv
24 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
25 Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation Terminated NCT02217982 Phase 4 Simethicone;Loperamide
26 A Study To Assess The Efficacy And Safety Of Bismuth Tripotassium Dicitrate (De-Nol) In Combination With Pantoprazole And Pantoprazole Monotherapy In Treatment Of Subjects With Nonsteroidal Anti-Inflammatory Drugs (NSAID)-Induced Gastropathy Terminated NCT02788123 Phase 4 bismuth tripotassium dicitrate;pantoprazole
27 Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1% Unknown status NCT02068859 Phase 3 Diclofenac Cream 8%;Diclofenac Gel 1%
28 Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection Unknown status NCT00197418 Phase 2, Phase 3 rabeprazole, amoxicillin, clarithromycin, metronidazole
29 Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori Unknown status NCT00149084 Phase 3 Lansoprazole, clarithromycin, amoxicillin
30 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00960869 Phase 3 PA32540;EC-Aspirin 325 mg
31 A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00961350 Phase 3 PA32540;EC Aspirin 325
32 Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric Ulcer Completed NCT00401752 Phase 3 Esomeprazole;Ranitidine
33 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT01129011 Phase 3 PN400 (VIMOVO);Naproxen
34 Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Gastric Ulcer Completed NCT01452711 Phase 3 TAK-438;Placebo;Lansoprazole;Placebo
35 Mucosta in Gastric Ulcer Treatment, Effectiveness and Safety Evaluation Completed NCT01150162 Phase 3 Rebamipide and Omeprazole;Omeprazole
36 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT00527787 Phase 3 PN400 (VIMOVO);Naproxen
37 Healing Effects of Autologous Platelet Rich Plasma on Gastric Ulcer Caused by Endoscopic Submucosal Dissection Completed NCT03220334 Phase 3 Platelet rich plasma;Normal saline
38 A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued Completed NCT00633672 Phase 3 Esomeprazole;Ranitidine;Esomeprazole
39 Prevention of Gastric Ulcers Completed NCT00629512 Phase 3 Esomeprazole;Esomeprazole;Placebo
40 A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only Completed NCT00633412 Phase 3 Esomeprazole;Ranitidine;Esomeprazole
41 Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn® Completed NCT01063920 Phase 2, Phase 3 LT-NS001;Naprosyn®
42 Study to Evaluate the Long-Term Safety of PA32540 in Subjects Who Are at Risk for Developing Aspirin-Associated Gastric Ulcers Completed NCT00995410 Phase 3 PA32540
43 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers. Completed NCT00367211 Phase 3 PN 200 tablets (500 mg naproxen and 20 mg omeprazole);Naproxen 500 mg tablets (PN 200 minus omeprazole)
44 Ulcer Prevention II Completed NCT00629928 Phase 3 Esomeprazole;Esomeprazole;Placebo
45 Efficacy and Safety of Lansoprazole on Gastric and Duodenal Ulcers in Patients Taking Nonsteroidal Anti-Inflammatory Drugs Completed NCT00787254 Phase 3 Lansoprazole;Gefarnate
46 Effect of Selective COX-2 Inhibition on Ulcer Healing Completed NCT00153673 Phase 3 celecoxib;Dologesics
47 A 12-month, Phase 3, Open-label, Multi-center Study to Evaluate the Long-term Safety of PN400 (VIMOVO) Completed NCT00527904 Phase 3 PN400 (VIMOVO);PN 400 (VIMOVO)
48 Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA) Completed NCT00441727 Phase 3 Esomeprazole 40 mg;Esomeprazole 20 mg;Placebo
49 Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study) Completed NCT01398410 Phase 2, Phase 3 Rabeprazole;Rabeprazole
50 PReventive Efficacy and Safety of rEbamipide on Nsaid Induced Mucosal Toxicity Completed NCT00576706 Phase 3 Rebamipide;Misoprostol

Search NIH Clinical Center for Gastric Ulcer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: stomach ulcer

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Genetic Tests for Gastric Ulcer

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Anatomical Context for Gastric Ulcer

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MalaCards organs/tissues related to Gastric Ulcer:

41
Testes, Endothelial, Thyroid, Spinal Cord, Liver, Eye, Heart
Sources

Publications for Gastric Ulcer

About this section

Articles related to Gastric Ulcer:

(show top 50) (show all 838)
# Title Authors Year
1
Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile. ( 29626382 )
2018
2
Accelerated gastric ulcer healing in thyroxine-treated rats; roles of gastric acid, mucus and inflammatory response. ( 29406826 )
2018
3
Prophylactic therapy with omeprazole for prevention of equine gastric ulcer syndrome (EGUS) in horses in active training: A meta-analysis. ( 29665126 )
2018
4
Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat. ( 29702486 )
2018
5
Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats. ( 29944876 )
2018
6
Hemorrhagic Stress-induced Gastric Ulcer in a Healthy Toddler. ( 29780141 )
2018
7
Therapeutic Endoscopy in Combination with Quadruple Therapy in Treating Bleeding Caused by Gastric Ulcer. ( 29643870 )
2018
8
Protective effect of bovine milk against HCl and ethanol-induced gastric ulcer in mice. ( 29477532 )
2018
9
Gastric Ulcer Bleeding Due to Left Gastric Artery Pseudoaneurysm. ( 29899435 )
2018
10
Pharmacogenetic testing by polymorphic markers 681G>A and 636G>A CYP2C19 gene in patients with acute coronary syndrome and gastric ulcer in the Republic of Sakha (Yakutia). ( 29738309 )
2018
11
Anti-<i>Helicobacter pylori</i> and Anti-Inflammatory Effects and Constituent Analysis of Modified Xiaochaihutang for the Treatment of Chronic Gastritis and Gastric Ulcer. ( 29681980 )
2018
12
Combination therapy with polydeoxyribonucleotide and proton pump inhibitor enhances therapeutic effectiveness for gastric ulcer in rats. ( 29665355 )
2018
13
Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models. ( 29136948 )
2018
14
Gastric ulcer related with gastrostomy feeding tube: Description of 3 cases and review of literature. ( 29366827 )
2018
15
Diagnostic accuracy of blood sucrose as a screening test for equine gastric ulcer syndrome (EGUS) in weanling foals. ( 29653546 )
2018
16
Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities. ( 29455967 )
2018
17
Antioxidant and anti-inflammatory activities of alpha lipoic acid protect against indomethacin-induced gastric ulcer in rats. ( 29486337 )
2018
18
Protective role of I^-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. ( 29433672 )
2018
19
Porcine stomachs with and without gastric ulcer differ in Lactobacillus load and strain characteristics. ( 29554439 )
2018
20
Prophylactic efficacy of patchoulene epoxide against ethanol-induced gastric ulcer in rats: Influence on oxidative stress, inflammation and apoptosis. ( 29339218 )
2018
21
Nonhealing Gastric Ulcer Due to Mesh Eroding Through GastricA Wall. ( 29574032 )
2018
22
1-Deoxynojirimycin (DNJ) Ameliorates Indomethacin-Induced Gastric Ulcer in Mice by Affecting NF-kappaB Signaling Pathway. ( 29725297 )
2018
23
Effects of quinine on gastric ulcer healing in Wistar rats. ( 28665790 )
2017
24
Comparison of the therapeutic effects of sildenafil citrate, heparin and neuropeptides in a rat model of acetic acid-induced gastric ulcer. ( 28807720 )
2017
25
Protective effects of bilobalide against ethanol-induced gastric ulcer in vivo/vitro. ( 27903426 )
2017
26
Enhancement of Gastric Ulcer Healing and Angiogenesis by Hepatocyte Growth Factor Gene Mediated by Attenuated Salmonella in Rats. ( 28049228 )
2017
27
Mean platelet volume, platelet distribution width and carcinoembryonic antigen to discriminate gastric cancer from gastric ulcer. ( 28977972 )
2017
28
Gastroprotective and Antiulcer Effects of Celastrus paniculatus Seed Oil Against Several Gastric Ulcer Models in Rats. ( 28816560 )
2017
29
Gastro-protective effect of methanol extract of <i>Vernonia amygdalina</i> (del.) leaf on aspirin-induced gastric ulcer in Wistar rats. ( 29657922 )
2017
30
An ulcerated gastric ulcer and pseudotumour with pancreatic affectation associated with immunoglobulin G4-related disease: a case report and literature review. ( 29082738 )
2017
31
Volatile organic metabolites identify patients with gastric carcinoma, gastric ulcer, or gastritis and control patients. ( 29200968 )
2017
32
Metastatic Renal Cell Carcinoma Presenting as Gastric Ulcer: Case Report and Literature Review. ( 28713604 )
2017
33
A Case of Gastric Ulcer With Mucosal Bridge. ( 29308020 )
2017
34
Surgical Scales: Primary Closure versus Gastric Resection for Perforated Gastric Ulcer - A Surgical Debate. ( 28584503 )
2017
35
Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer. ( 29243969 )
2017
36
Involvement of MAPK/NF-I_B signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer. ( 28926923 )
2017
37
Analyzing the influence of gastric intestinal metaplasia on gastric ulcer healing in Helicobacter pylori-infected patients without atrophic gastritis. ( 28049442 )
2017
38
Perforated Gastric Ulcer Associated with Anti-Angiogenic Therapy. ( 29255770 )
2017
39
Protective effect of salusin-I+ and salusin-I^ against ethanol-induced gastric ulcer in rats. ( 28917082 )
2017
40
Acute ischemic gastric ulcer. ( 28991536 )
2017
41
Exendin-4, a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats. ( 29095895 )
2017
42
Cigarette Lighter Fluid Induced Gastric Ulcer: A Severe Complication of Delayed Foreign Body Removal. ( 28894611 )
2017
43
Cytomegalovirus Gastric Ulcer Complicated with Pyloric Obstruction in a Patient with Ulcerative Colitis. ( 28637105 )
2017
44
Large intramural hematoma and gastric ulcer after EMR of a small gastric polyp. ( 29223380 )
2017
45
Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf. ( 29258255 )
2017
46
Anti-inflammatory effects of nesfatin-1 on acetic acid-induced gastric ulcer in rats: involvement of cyclo-oxygenase pathway. ( 29375052 )
2017
47
Mechanistic evaluation of gastroprotective effects of Kangfuxin on ethanol-induced gastric ulcer in mice. ( 28606470 )
2017
48
A Rare Case of Gastric Ulcer Penetrating the Pancreas that was Successfully Managed by Conservative Therapy. ( 28794357 )
2017
49
Discovery of a COX-2 selective inhibitor hit with anti-inflammatory activity and gastric ulcer protective effect. ( 29076755 )
2017
50
Antiplatelet drug ticagrelor delays gastric ulcer healing in rats. ( 29042978 )
2017
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Variations for Gastric Ulcer

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Expression for Gastric Ulcer

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Search GEO for disease gene expression data for Gastric Ulcer.
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Pathways for Gastric Ulcer

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Pathways related to Gastric Ulcer according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 13.06 CXCL8 EGF FGF2 HGF IL1B IL1RN
2
Pathways in cancer 37
12.66 CXCL8 EGF FGF2 HGF PTGS2
3
MAPK signaling pathway 1 37
12.6 EGF FGF2 HGF IL1B
4
NF-KappaB Family Pathway 64
Show member pathways
 12.53 EGF FGF2 HGF IL1B
5
NF-kappaB Signaling 4
12.37 IL1B IL1RN PTGS1 PTGS2
6
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.14 EGF HRH2 PTGS2 TFF1
7
Toll Comparative Pathway 64
Show member pathways
 12.12 CXCL8 IL1B PTGS2
8
Colorectal Cancer Metastasis 64
12.04 EGF MMP7 PTGS2
9
Arachidonic acid metabolism 66
Show member pathways
 12.03 CYP2C19 PTGS1 PTGS2
10
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.02 CXCL8 IL1B IL1RN
11
IL-1 Family Signaling Pathways 65
Show member pathways
 11.98 CXCL8 IL1B IL1RN PTGS2
12
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.9 EGF FGF2 HGF
13
Spinal Cord Injury 1
11.85 CXCL8 IL1B PTGS2
14
Linoleic acid metabolism 37
Show member pathways
 11.82 CYP2C19 PTGS1 PTGS2
15
Serotonergic synapse 37
11.8 CYP2C19 PTGS1 PTGS2
16
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.78 CXCL8 EGF FGF2 HGF IL1B
17
NF-kappa B signaling pathway 37
11.7 CXCL8 IL1B PTGS2
18
Angiogenesis (CST) 4
11.51 FGF2 HGF MMP7 PTGS2
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.5 CXCL8 IL1B PTGS2
20
Interleukin-4 and 13 signaling 66
11.41 CXCL8 FGF2 HGF IL1B PTGS2
21
Malaria 37
11.34 CXCL8 HGF IL1B
22
Differentiation Pathway 1
11.31 EGF FGF2 HGF
23
Interleukin-10 signaling 66
11.15 CXCL8 IL1B IL1RN PTGS2
24
Prostaglandin Synthesis and Regulation 1
11.14 PTGS1 PTGS2
25
Ibuprofen Pathway, Pharmacodynamics 61
11.1 PTGS1 PTGS2
26
HETE and HPETE biosynthesis and metabolism 22
Show member pathways
 11.08 PTGS1 PTGS2
27
Eicosanoid Synthesis 1
11 PTGS1 PTGS2
28
Prostaglandin 2 biosynthesis and metabolism FM 22
10.98 PTGS1 PTGS2
29
Syndecan-1-mediated signaling events 1
10.83 HGF MMP7
30
Lung fibrosis 1
10.82 CXCL8 EGF FGF2 HGF IL1B
31
Overview of nanoparticle effects 1
10.78 CXCL8 PTGS1 PTGS2
32
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 61
10.76 PTGS1 PTGS2
33
Secretion of Hydrochloric Acid in Parietal Cells 1
10.19 GAST HRH2
Sources

GO Terms for Gastric Ulcer

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Cellular components related to Gastric Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL8 EGF FGF2 GAST HGF IL1B
2 organelle membrane GO:0031090 9.33 CYP2C19 PTGS1 PTGS2
3 extracellular space GO:0005615 9.28 CXCL8 EGF FGF2 GAST HGF IL1B

Biological processes related to Gastric Ulcer according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.9 CXCL8 HRH2 IL1B IL1RN
2 negative regulation of cell proliferation GO:0008285 9.85 CXCL8 IL1B PTGS2 TFF1
3 positive regulation of cell proliferation GO:0008284 9.83 EGF FGF2 HGF IL1B PTGS2
4 MAPK cascade GO:0000165 9.8 EGF FGF2 HGF IL1B
5 angiogenesis GO:0001525 9.76 CXCL8 EGF FGF2 PTGS2
6 peptidyl-tyrosine phosphorylation GO:0018108 9.75 EGF FGF2 HGF
7 positive regulation of protein kinase B signaling GO:0051897 9.74 EGF FGF2 HGF
8 inflammatory response GO:0006954 9.72 CXCL8 IL1B IL1RN PTGS1 PTGS2
9 phosphatidylinositol phosphorylation GO:0046854 9.7 EGF FGF2 HGF
10 cellular response to mechanical stimulus GO:0071260 9.65 IL1B MMP7 PTGS2
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.59 IL1B PTGS2
12 positive regulation of mitotic nuclear division GO:0045840 9.58 EGF IL1B
13 prostaglandin metabolic process GO:0006693 9.56 PTGS1 PTGS2
14 positive regulation of angiogenesis GO:0045766 9.56 CXCL8 FGF2 HGF IL1B
15 prostaglandin biosynthetic process GO:0001516 9.54 PTGS1 PTGS2
16 cyclooxygenase pathway GO:0019371 9.51 PTGS1 PTGS2
17 activation of MAPK activity GO:0000187 9.46 EGF FGF2 HGF IL1B
18 cytokine-mediated signaling pathway GO:0019221 9.43 CXCL8 FGF2 HGF IL1B IL1RN PTGS2
19 positive regulation of fever generation GO:0031622 9.4 IL1B PTGS2
20 fever generation GO:0001660 9.37 IL1B IL1RN
21 regulation of signaling receptor activity GO:0010469 9.17 CXCL8 FGF2 GAST HGF IL1B IL1RN

Molecular functions related to Gastric Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.63 EGF FGF2 HGF
2 heme binding GO:0020037 9.58 CYP2C19 PTGS1 PTGS2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.5 EGF FGF2 HGF
4 cytokine activity GO:0005125 9.46 CXCL8 FGF2 IL1B IL1RN
5 peroxidase activity GO:0004601 9.43 PTGS1 PTGS2
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 EGF FGF2 HGF
7 interleukin-1 receptor binding GO:0005149 9.37 IL1B IL1RN
8 growth factor activity GO:0008083 9.26 EGF FGF2 HGF TFF1
9 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2
Sources

Sources for Gastric Ulcer

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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