MCID: GST090
MIFTS: 28

Gastroduodenal Crohn's Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastroduodenal Crohn's Disease

MalaCards integrated aliases for Gastroduodenal Crohn's Disease:

Name: Gastroduodenal Crohn's Disease 12 15
Upper Gi Crohn's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060191
ICD10 34 K50.0

Summaries for Gastroduodenal Crohn's Disease

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in stomach and located in duodenum, has symptom nausea, has symptom vomiting, has symptom weight loss and has symptom loss of appetite.

MalaCards based summary : Gastroduodenal Crohn's Disease, also known as upper gi crohn's disease, is related to crohn's disease and pancreatitis, and has symptoms including vomiting, weight loss and nausea. An important gene associated with Gastroduodenal Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2). Affiliated tissues include small intestine, skin and stomach.

Related Diseases for Gastroduodenal Crohn's Disease

Diseases related to Gastroduodenal Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 10.7
2 pancreatitis 10.1
3 acute pancreatitis 9.9
4 fungal esophagitis 9.9 ATP12A ATP4A
5 diclofenac allergy 9.9 ATP12A ATP4A
6 neonatal candidiasis 9.9 ATP12A ATP4A
7 photoallergic dermatitis 9.9 ATP12A ATP4A
8 squamous papillomatosis 9.9 ATP12A ATP4A
9 toxic megacolon 9.9 ATP12A ATP4A
10 aspiration pneumonitis 9.9 ATP12A ATP4A
11 gastric antral vascular ectasia 9.9 ATP12A ATP4A
12 esophageal candidiasis 9.9 ATP12A ATP4A
13 acute laryngitis 9.9 ATP12A ATP4A
14 laryngitis 9.9 ATP12A ATP4A
15 duodenitis 9.9 ATP12A ATP4A
16 rumination disorder 9.9 ATP12A ATP4A
17 active peptic ulcer disease 9.9 ATP12A ATP4A
18 congenital disorder of deglycosylation 9.9 ATP12A ATP4A
19 bladder calculus 9.9 ATP12A ATP4A
20 ischemic neuropathy 9.9 ATP12A ATP4A
21 bile reflux 9.9 ATP12A ATP4A
22 capillary disease 9.9 ATP12A ATP4A
23 peptic esophagitis 9.9 ATP12A ATP4A
24 dyskinesia of esophagus 9.9 ATP12A ATP4A
25 hernia, hiatus 9.9 ATP12A ATP4A
26 anismus 9.9 ATP12A ATP4A
27 postsurgical hypothyroidism 9.8 ATP12A ATP4A
28 lymphocytic colitis 9.8 ATP12A ATP4A
29 esophageal atresia/tracheoesophageal fistula 9.8 ATP12A ATP4A
30 clostridium difficile colitis 9.8 ATP12A ATP4A
31 diarrhea 1, secretory chloride, congenital 9.8 ATP12A ATP4A
32 esophagitis, eosinophilic, 1 9.8 ATP12A ATP4A
33 microscopic colitis 9.8 ATP12A ATP4A
34 laryngeal tuberculosis 9.8 ATP12A ATP4A
35 chronic laryngitis 9.8 ATP12A ATP4A
36 eosinophilic gastritis 9.8 ATP12A ATP4A
37 esophagus adenocarcinoma 9.8 ATP12A ATP4A
38 chronic intestinal vascular insufficiency 9.8 ATP12A ATP4A
39 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8 ATP12A ATP4A
40 jejunoileitis 9.8 ATP12A ATP4A
41 esophageal varix 9.8 ATP12A ATP4A
42 superior mesenteric artery syndrome 9.8 ATP12A ATP4A
43 gastric lymphoma 9.8 ATP12A ATP4A
44 lower urinary tract calculus 9.8 ATP12A ATP4A
45 myopathy, x-linked, with excessive autophagy 9.8 ATP12A ATP4A
46 aspiration pneumonia 9.8 ATP12A ATP4A
47 functional gastric disease 9.8 ATP12A ATP4A
48 pneumatosis cystoides intestinalis 9.8 ATP12A ATP4A
49 lateral medullary syndrome 9.8 ATP12A ATP4A
50 microinvasive gastric cancer 9.7 ATP12A ATP4A

Graphical network of the top 20 diseases related to Gastroduodenal Crohn's Disease:



Diseases related to Gastroduodenal Crohn's Disease

Symptoms & Phenotypes for Gastroduodenal Crohn's Disease

Symptoms:

12
  • vomiting
  • weight loss
  • nausea
  • loss of appetite

Drugs & Therapeutics for Gastroduodenal Crohn's Disease

Search Clinical Trials , NIH Clinical Center for Gastroduodenal Crohn's Disease

Genetic Tests for Gastroduodenal Crohn's Disease

Anatomical Context for Gastroduodenal Crohn's Disease

MalaCards organs/tissues related to Gastroduodenal Crohn's Disease:

42
Small Intestine, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Gastroduodenal Crohn's Disease:

20
Stomach, Duodenum

Publications for Gastroduodenal Crohn's Disease

Articles related to Gastroduodenal Crohn's Disease:

(show all 28)
# Title Authors Year
1
Efficacy of Endoscopic Dilation of Gastroduodenal Crohn's Disease Strictures: A Systematic Review and Meta-Analysis of Individual Patient Data. ( 30503966 )
2018
2
Isolated gastroduodenal Crohn's disease in a septuagenarian man. ( 24756277 )
2014
3
Infliximab treatment of massive upper gastrointestinal bleeding in gastroduodenal Crohn's disease. ( 19115158 )
2008
4
Isolated gastroduodenal Crohn's disease presenting with acute pancreatitis. ( 21960926 )
2008
5
Gastroduodenal Crohn's disease and pancreatitis. ( 21960927 )
2008
6
Treatment of gastroduodenal Crohn's disease. ( 15711048 )
2005
7
Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity. ( 16416181 )
2005
8
Gastroduodenal Crohn's disease. ( 15605018 )
2004
9
Gastroduodenal Crohn's disease: medical management. ( 12769447 )
2003
10
Severe gastroduodenal Crohn's disease: surgical treatment. ( 12769448 )
2003
11
Gastroduodenal Crohn's disease. ( 16278730 )
2003
12
Gastroduodenal Crohn's disease: the focus is on focality. ( 9041268 )
1997
13
Long-term outcome of endoscopic balloon dilation in obstructive gastroduodenal Crohn's disease. ( 9360875 )
1997
14
Repeated hydrostatic balloon dilation in obstructive gastroduodenal Crohn's disease. ( 1916177 )
1991
15
The diagnosis of gastroduodenal Crohn's disease by endoscopic biopsy. ( 2617164 )
1989
16
Clinical features of gastroduodenal Crohn's disease in adolescents. ( 2709248 )
1989
17
Gastroduodenal Crohn's disease in childhood. ( 2809935 )
1989
18
The surgical treatment of gastroduodenal Crohn's disease. ( 4073768 )
1985
19
Gastric retention of enteric-coated sulfasalazine tablets. A complication of gastroduodenal Crohn's disease. ( 6149106 )
1984
20
Gastroduodenal Crohn's disease. ( 6726063 )
1984
21
Gastroduodenal Crohn's disease with radiographic, endoscopic, and histologic correlation. ( 6629882 )
1983
22
Recurrent free perforation in gastroduodenal Crohn's disease. ( 6637961 )
1983
23
Gastroduodenal Crohn's disease. Differential diagnosis and treatment. ( 6647159 )
1983
24
Gastroduodenal Crohn's disease: diagnosis and selection of treatment. ( 6861031 )
1983
25
Isolated gastroduodenal Crohn's disease in a ten-year-old girl. ( 7433335 )
1980
26
Gastroduodenal Crohn's disease. ( 441766 )
1979
27
Endoscopic features of gastroduodenal Crohn's disease. ( 1245289 )
1976
28
Gastroduodenal Crohn's disease presenting as biliary colic. ( 1146804 )
1975

Variations for Gastroduodenal Crohn's Disease

Expression for Gastroduodenal Crohn's Disease

Search GEO for disease gene expression data for Gastroduodenal Crohn's Disease.

Pathways for Gastroduodenal Crohn's Disease

GO Terms for Gastroduodenal Crohn's Disease

Cellular components related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.62 ATP12A NOD2

Biological processes related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.58 ATP12A ATP4A CBLIF
2 potassium ion transport GO:0006813 9.43 ATP12A ATP4A
3 potassium ion import across plasma membrane GO:1990573 9.37 ATP12A ATP4A
4 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
5 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
7 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
8 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Gastroduodenal Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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