MCID: GST090
MIFTS: 31

Gastroduodenal Crohn's Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastroduodenal Crohn's Disease

MalaCards integrated aliases for Gastroduodenal Crohn's Disease:

Name: Gastroduodenal Crohn's Disease 12 15
Upper Gi Crohn's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060191
ICD10 32 K50.0

Summaries for Gastroduodenal Crohn's Disease

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in stomach and located in duodenum, has symptom nausea, has symptom vomiting, has symptom weight loss and has symptom loss of appetite.

MalaCards based summary : Gastroduodenal Crohn's Disease, also known as upper gi crohn's disease, is related to crohn's disease and duodenal obstruction, and has symptoms including vomiting, weight loss and nausea. An important gene associated with Gastroduodenal Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Apoptosis-related network due to altered Notch3 in ovarian cancer and Aryl Hydrocarbon Receptor Pathway. Affiliated tissues include stomach, duodenum and small intestine, and related phenotype is homeostasis/metabolism.

Related Diseases for Gastroduodenal Crohn's Disease

Diseases related to Gastroduodenal Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 30.7 TPMT TNF NOD2
2 duodenal obstruction 30.2 ATP4A ATP12A
3 ileitis 30.0 TNF NOD2
4 vagus nerve disease 10.2 ATP4A ATP12A
5 necrotizing gastritis 10.2 ATP4A ATP12A
6 scalp dermatosis 10.2 ATP4A ATP12A
7 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
8 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
9 lingual goiter 10.2 ATP4A ATP12A
10 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
11 bacterial esophagitis 10.2 ATP4A ATP12A
12 cascade stomach 10.2 ATP4A ATP12A
13 benzylpenicillin allergy 10.2 ATP4A ATP12A
14 median arcuate ligament syndrome 10.2 ATP4A ATP12A
15 afferent loop syndrome 10.2 ATP4A ATP12A
16 cervix erosion 10.2 ATP4A ATP12A
17 angiodysplasia of intestine 10.2 ATP4A ATP12A
18 angiodysplasia 10.2 ATP4A ATP12A
19 granulomatous gastritis 10.2 ATP4A ATP12A
20 laryngeal tuberculosis 10.2 ATP4A ATP12A
21 fungal esophagitis 10.2 ATP4A ATP12A
22 dieulafoy lesion 10.2 ATP4A ATP12A
23 esophagus melanoma 10.2 ATP4A ATP12A
24 cefuroxime allergy 10.2 ATP4A ATP12A
25 emphysematous cholecystitis 10.2 ATP4A ATP12A
26 gastric gastrinoma 10.2 ATP4A ATP12A
27 superior mesenteric artery syndrome 10.2 ATP4A ATP12A
28 pneumatosis cystoides intestinalis 10.2 ATP4A ATP12A
29 chronic laryngitis 10.2 ATP4A ATP12A
30 peptic ulcer perforation 10.2 ATP4A ATP12A
31 viral laryngitis 10.2 ATP4A ATP12A
32 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP4A ATP12A
33 central nervous system origin vertigo 10.2 ATP4A ATP12A
34 rumination disorder 10.2 ATP4A ATP12A
35 internal hemorrhoid 10.2 ATP4A ATP12A
36 acute laryngitis 10.2 ATP4A ATP12A
37 gastroduodenitis 10.2 ATP4A ATP12A
38 chronic intestinal vascular insufficiency 10.2 ATP4A ATP12A
39 barbiturate abuse 10.2 ATP4A ATP12A
40 duodenal gastrinoma 10.2 ATP4A ATP12A
41 gastric dilatation 10.2 ATP4A ATP12A
42 sigmoid disease 10.2 TNF NOD2
43 gastric hemangioma 10.2 ATP4A ATP12A
44 blind loop syndrome 10.2 ATP4A ATP12A
45 polycystic echinococcosis 10.2 ATP4A ATP12A
46 diclofenac allergy 10.2 ATP4A ATP12A
47 lymphocytic gastritis 10.2 ATP4A ATP12A
48 x-linked chondrodysplasia punctata 1 10.2 ATP4A ATP12A
49 mediastinitis 10.2 ATP4A ATP12A
50 pancreatic gastrinoma 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastroduodenal Crohn's Disease:



Diseases related to Gastroduodenal Crohn's Disease

Symptoms & Phenotypes for Gastroduodenal Crohn's Disease

Symptoms:

12
  • vomiting
  • weight loss
  • nausea
  • loss of appetite

MGI Mouse Phenotypes related to Gastroduodenal Crohn's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 ATP12A ATP4A CCK NOD2 NQO1 TNF

Drugs & Therapeutics for Gastroduodenal Crohn's Disease

Search Clinical Trials , NIH Clinical Center for Gastroduodenal Crohn's Disease

Genetic Tests for Gastroduodenal Crohn's Disease

Anatomical Context for Gastroduodenal Crohn's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gastroduodenal Crohn's Disease:

19
Stomach, Duodenum

MalaCards organs/tissues related to Gastroduodenal Crohn's Disease:

40
Small Intestine, Bone, Heart, Skin, Cervix

Publications for Gastroduodenal Crohn's Disease

Articles related to Gastroduodenal Crohn's Disease:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Efficacy of Endoscopic Dilation of Gastroduodenal Crohn's Disease Strictures: A Systematic Review and Meta-Analysis of Individual Patient Data. 61
30503966 2019
2
Increased Prevalence of Esophageal Eosinophilia in Patients with Inflammatory Bowel Disease. 61
31111034 2019
3
Stricturing and Fistulizing Crohn's Disease Is Associated with Anti-tumor Necrosis Factor-Induced Psoriasis in Patients with Inflammatory Bowel Disease. 61
29736839 2018
4
Duodenal Crohn's Disease-a Diagnostic Conundrum. 61
29043578 2018
5
Crohn's disease confined to the duodenum: A case report. 61
27326400 2016
6
Crohn's Disease of the Foregut. 61
26596921 2015
7
Crohn's disease presenting as gastric outlet obstruction. 61
25477016 2014
8
Isolated gastroduodenal Crohn's disease in a septuagenarian man. 61
24756277 2014
9
[Infliximab in the treatment of refractory gastroduodenal Crohn's disease]. 61
24029174 2014
10
Pyloric stenosis associated Crohn's disease responding to adalimumab therapy. 61
23494865 2012
11
Surgical management of localized Crohn's disease of the fourth part of the duodenum. 61
25197511 2010
12
Infliximab treatment of massive upper gastrointestinal bleeding in gastroduodenal Crohn's disease. 61
19115158 2008
13
Isolated gastroduodenal Crohn's disease presenting with acute pancreatitis. 61
21960926 2008
14
Gastroduodenal Crohn's disease and pancreatitis. 61
21960927 2008
15
Screening for celiac disease in short bowel syndrome. 61
18203966 2008
16
[Fistulizing gastroduodenal Crohn's disease histologically mimicking MALT lymphoma]. 61
17198481 2006
17
[Gastric Crohn's disease as a cause of gastrointestinal bleeding after gastroscopy--diagnostic difficulties]. 61
17441387 2006
18
Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity. 61
16416181 2005
19
Treatment of gastroduodenal Crohn's disease. 61
15711048 2005
20
Gastroduodenal Crohn's disease. 61
15605018 2004
21
Gastroduodenal Crohn's disease. 61
16278730 2003
22
Gastroduodenal Crohn's disease: medical management. 61
12769447 2003
23
Severe gastroduodenal Crohn's disease: surgical treatment. 61
12769448 2003
24
[Isolated gastroduodenal Crohn's disease: a case report]. 61
11432174 2001
25
[Gastroduodenal Crohn's disease - report of 4 cases and review of the literature]. 61
11586998 2001
26
Helicobacter pylori-negative ulcer disease. 61
10779218 2000
27
Gastroduodenal fistulas in Crohn's disease: clinical features and management. 61
9788393 1998
28
[Gastroduodenal involvement and circumscribed intestinal stricture in Crohn disease]. 61
9622891 1998
29
Long-term outcome of endoscopic balloon dilation in obstructive gastroduodenal Crohn's disease. 61
9360875 1997
30
Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. 61
9149205 1997
31
Gastroduodenal Crohn's disease: the focus is on focality. 61
9041268 1997
32
Prolonged use of gastrostomy for enteral hyperalimentation in children with Crohn's disease. 61
7611202 1995
33
[Gastroduodenal Crohn's disease: report of a case and review of Japanese literatures]. 61
8361061 1993
34
[Gastroduodenal Crohn's disease associated with an alpha 1 antitrypsin deficiency]. 61
1570653 1992
35
Repeated hydrostatic balloon dilation in obstructive gastroduodenal Crohn's disease. 61
1916177 1991
36
Perianal complications of pediatric Crohn's disease. 61
2061798 1991
37
Gastroduodenal Crohn's disease in childhood. 61
2809935 1989
38
Clinical features of gastroduodenal Crohn's disease in adolescents. 61
2709248 1989
39
The diagnosis of gastroduodenal Crohn's disease by endoscopic biopsy. 61
2617164 1989
40
Gastric and duodenal fistulas in Crohn's disease. 61
4054528 1985
41
The surgical treatment of gastroduodenal Crohn's disease. 61
4073768 1985
42
Gastric retention of enteric-coated sulfasalazine tablets. A complication of gastroduodenal Crohn's disease. 61
6149106 1984
43
Gastroduodenal Crohn's disease. 61
6726063 1984
44
Gastroduodenal Crohn's disease. Differential diagnosis and treatment. 61
6647159 1983
45
Recurrent free perforation in gastroduodenal Crohn's disease. 61
6637961 1983
46
Crohn's disease of the stomach with outlet obstruction: a case report and review of therapy. 61
6415159 1983
47
Gastroduodenal Crohn's disease with radiographic, endoscopic, and histologic correlation. 61
6629882 1983
48
[Endoscopic and histologic findings in gastroduodenal Crohn's disease]. 61
6632333 1983
49
[Gastroduodenal Crohn disease--a case report]. 61
6622953 1983
50
Gastroduodenal Crohn's disease: diagnosis and selection of treatment. 61
6861031 1983

Variations for Gastroduodenal Crohn's Disease

Expression for Gastroduodenal Crohn's Disease

Search GEO for disease gene expression data for Gastroduodenal Crohn's Disease.

Pathways for Gastroduodenal Crohn's Disease

Pathways related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2 10.84 TNF NQO1
3 10.64 TNF NQO1
4 9.98 TNF NOD2

GO Terms for Gastroduodenal Crohn's Disease

Biological processes related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.55 TNF NOD2
2 positive regulation of MAP kinase activity GO:0043406 9.54 TNF NOD2
3 positive regulation of interleukin-8 production GO:0032757 9.52 TNF NOD2
4 positive regulation of interleukin-1 beta production GO:0032731 9.51 TNF NOD2
5 positive regulation of neuron apoptotic process GO:0043525 9.49 TNF NQO1
6 positive regulation of protein complex assembly GO:0031334 9.48 TNF CCK
7 JNK cascade GO:0007254 9.46 TNF NOD2
8 positive regulation of phagocytosis GO:0050766 9.43 TNF NOD2
9 potassium ion import across plasma membrane GO:1990573 9.4 ATP4A ATP12A
10 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.37 TNF NOD2
11 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
12 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
13 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
14 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP4A ATP12A
15 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 8.62 TNF NOD2

Molecular functions related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Gastroduodenal Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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