MCID: GST090
MIFTS: 28

Gastroduodenal Crohn's Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastroduodenal Crohn's Disease

MalaCards integrated aliases for Gastroduodenal Crohn's Disease:

Name: Gastroduodenal Crohn's Disease 12 15
Upper Gi Crohn's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060191
ICD10 33 K50.0

Summaries for Gastroduodenal Crohn's Disease

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in stomach and located in duodenum, has symptom nausea, has symptom vomiting, has symptom weight loss and has symptom loss of appetite.

MalaCards based summary : Gastroduodenal Crohn's Disease, also known as upper gi crohn's disease, is related to fungal esophagitis and bladder calculus, and has symptoms including nausea, vomiting and weight loss. An important gene associated with Gastroduodenal Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2). Affiliated tissues include stomach, duodenum and small intestine, and related phenotype is homeostasis/metabolism.

Related Diseases for Gastroduodenal Crohn's Disease

Diseases related to Gastroduodenal Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.1 ATP12A ATP4A
2 bladder calculus 10.1 ATP12A ATP4A
3 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
4 neonatal candidiasis 10.1 ATP12A ATP4A
5 photoallergic dermatitis 10.1 ATP12A ATP4A
6 squamous papillomatosis 10.1 ATP12A ATP4A
7 acute laryngitis 10.1 ATP12A ATP4A
8 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
9 toxic megacolon 10.1 ATP12A ATP4A
10 aspiration pneumonitis 10.1 ATP12A ATP4A
11 postsurgical hypothyroidism 10.1 ATP12A ATP4A
12 gastric antral vascular ectasia 10.1 ATP12A ATP4A
13 esophageal candidiasis 10.1 ATP12A ATP4A
14 duodenitis 10.1 ATP12A ATP4A
15 rumination disorder 10.1 ATP12A ATP4A
16 bile reflux 10.1 ATP12A ATP4A
17 active peptic ulcer disease 10.1 ATP12A ATP4A
18 laryngeal disease 10.1 ATP12A ATP4A
19 ischemic neuropathy 10.1 ATP12A ATP4A
20 capillary disease 10.1 ATP12A ATP4A
21 peptic esophagitis 10.1 ATP12A ATP4A
22 duodenal disease 10.1 ATP12A ATP4A
23 dyskinesia of esophagus 10.1 ATP12A ATP4A
24 hernia, hiatus 10.1 ATP12A ATP4A
25 congenital disorder of deglycosylation 10.1 ATP12A ATP4A
26 anismus 10.0 ATP12A ATP4A
27 esophageal atresia/tracheoesophageal fistula 10.0 ATP12A ATP4A
28 laryngitis 10.0 ATP12A ATP4A
29 laryngeal tuberculosis 10.0 ATP12A ATP4A
30 lymphocytic colitis 10.0 ATP12A ATP4A
31 clostridium difficile colitis 10.0 ATP12A ATP4A
32 lower urinary tract calculus 10.0 ATP12A ATP4A
33 aspiration pneumonia 10.0 ATP12A ATP4A
34 diarrhea 1, secretory chloride, congenital 10.0 ATP12A ATP4A
35 chronic laryngitis 10.0 ATP12A ATP4A
36 chronic intestinal vascular insufficiency 10.0 ATP12A ATP4A
37 eosinophilic gastritis 10.0 ATP12A ATP4A
38 polyposis, skin pigmentation, alopecia, and fingernail changes 10.0 ATP12A ATP4A
39 esophageal varix 10.0 ATP12A ATP4A
40 esophagus adenocarcinoma 9.9 ATP12A ATP4A
41 myopathy, x-linked, with excessive autophagy 9.9 ATP12A ATP4A
42 gastric lymphoma 9.9 ATP12A ATP4A
43 pneumatosis cystoides intestinalis 9.9 ATP12A ATP4A
44 superior mesenteric artery syndrome 9.9 ATP12A ATP4A
45 jejunoileitis 9.9 ATP12A ATP4A
46 functional gastric disease 9.8 ATP12A ATP4A
47 lateral medullary syndrome 9.8 ATP12A ATP4A
48 paine syndrome 9.8 ATP12A ATP4A
49 esophagitis, eosinophilic, 1 9.8 ATP12A ATP4A
50 cloacal exstrophy 9.7 ATP12A ATP4A

Graphical network of the top 20 diseases related to Gastroduodenal Crohn's Disease:



Diseases related to Gastroduodenal Crohn's Disease

Symptoms & Phenotypes for Gastroduodenal Crohn's Disease

Symptoms:

12
  • nausea
  • vomiting
  • weight loss
  • loss of appetite

MGI Mouse Phenotypes related to Gastroduodenal Crohn's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 ATP12A ATP4A GIF NOD2 TGM2

Drugs & Therapeutics for Gastroduodenal Crohn's Disease

Search Clinical Trials , NIH Clinical Center for Gastroduodenal Crohn's Disease

Genetic Tests for Gastroduodenal Crohn's Disease

Anatomical Context for Gastroduodenal Crohn's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gastroduodenal Crohn's Disease:

19
Stomach, Duodenum

MalaCards organs/tissues related to Gastroduodenal Crohn's Disease:

41
Small Intestine

Publications for Gastroduodenal Crohn's Disease

Articles related to Gastroduodenal Crohn's Disease:

(show all 21)
# Title Authors Year
1
Isolated gastroduodenal Crohn's disease in a septuagenarian man. ( 24756277 )
2014
2
Isolated gastroduodenal Crohn's disease presenting with acute pancreatitis. ( 21960926 )
2008
3
Infliximab treatment of massive upper gastrointestinal bleeding in gastroduodenal Crohn's disease. ( 19115158 )
2008
4
Gastroduodenal Crohn's disease and pancreatitis. ( 21960927 )
2008
5
Treatment of gastroduodenal Crohn's disease. ( 15711048 )
2005
6
Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity. ( 16416181 )
2005
7
Gastroduodenal Crohn's disease. ( 15605018 )
2004
8
Gastroduodenal Crohn's disease. ( 16278730 )
2003
9
Severe gastroduodenal Crohn's disease: surgical treatment. ( 12769448 )
2003
10
Gastroduodenal Crohn's disease: medical management. ( 12769447 )
2003
11
Long-term outcome of endoscopic balloon dilation in obstructive gastroduodenal Crohn's disease. ( 9360875 )
1997
12
Gastroduodenal Crohn's disease: the focus is on focality. ( 9041268 )
1997
13
Repeated hydrostatic balloon dilation in obstructive gastroduodenal Crohn's disease. ( 1916177 )
1991
14
The diagnosis of gastroduodenal Crohn's disease by endoscopic biopsy. ( 2617164 )
1989
15
Gastroduodenal Crohn's disease in childhood. ( 2809935 )
1989
16
Clinical features of gastroduodenal Crohn's disease in adolescents. ( 2709248 )
1989
17
The surgical treatment of gastroduodenal Crohn's disease. ( 4073768 )
1985
18
Gastric retention of enteric-coated sulfasalazine tablets. A complication of gastroduodenal Crohn's disease. ( 6149106 )
1984
19
Gastroduodenal Crohn's disease. ( 6726063 )
1984
20
Gastroduodenal Crohn's disease. Differential diagnosis and treatment. ( 6647159 )
1983
21
Endoscopic features of gastroduodenal Crohn's disease. ( 1245289 )
1976

Variations for Gastroduodenal Crohn's Disease

Expression for Gastroduodenal Crohn's Disease

Search GEO for disease gene expression data for Gastroduodenal Crohn's Disease.

Pathways for Gastroduodenal Crohn's Disease

GO Terms for Gastroduodenal Crohn's Disease

Biological processes related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.58 ATP12A ATP4A GIF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.48 NOD2 TGM2
3 potassium ion transport GO:0006813 9.46 ATP12A ATP4A
4 sodium ion transport GO:0006814 9.43 ATP12A ATP4A
5 potassium ion import GO:0010107 9.37 ATP12A ATP4A
6 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
7 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
8 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
9 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Gastroduodenal Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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