MCID: GST038
MIFTS: 20

Gastrointestinal Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal Adenoma

MalaCards integrated aliases for Gastrointestinal Adenoma:

Name: Gastrointestinal Adenoma 12 15
Digestive System Adenoma 71
Gi Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4147
NCIt 49 C36207
UMLS 71 C0948101

Summaries for Gastrointestinal Adenoma

MalaCards based summary : Gastrointestinal Adenoma, also known as digestive system adenoma, is related to familial adenomatous polyposis and jejunal cancer. An important gene associated with Gastrointestinal Adenoma is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component). Affiliated tissues include colon, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Gastrointestinal Adenoma

Diseases related to Gastrointestinal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 familial adenomatous polyposis 28.9 SMAD4 PMS2 MUTYH
2 jejunal cancer 10.2 PMS2 MUTYH
3 jejunal adenocarcinoma 10.2 PMS2 MUTYH
4 colorectal cancer, hereditary nonpolyposis, type 6 10.2 PMS2 MUTYH
5 sebaceous gland neoplasm 10.1 PMS2 MUTYH
6 sebaceous adenoma 10.1 PMS2 MUTYH
7 colorectal cancer, hereditary nonpolyposis, type 5 10.1 PMS2 MUTYH
8 adenoma 10.1
9 muir-torre syndrome 9.8 PMS2 MUTYH AFAP1
10 desmoid tumor 9.8 MUTYH AFAP1
11 small intestine adenocarcinoma 9.8 SMAD4 PMS2
12 colorectal adenoma 9.7
13 adenocarcinoma 9.7
14 apc-associated polyposis conditions 9.7
15 hereditary mixed polyposis syndrome 9.6 SMAD4 PMS2 MUTYH
16 juvenile polyposis syndrome 9.6 SMAD4 PMS2 MUTYH
17 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.6 PMS2 MUTYH MIR483
18 colonic benign neoplasm 9.6 SMAD4 PMS2
19 hereditary breast ovarian cancer syndrome 9.6 SMAD4 PMS2 MUTYH
20 autosomal genetic disease 9.5 PMS2 MUTYH MIR483
21 polyposis, skin pigmentation, alopecia, and fingernail changes 9.4 SMAD4 MUTYH AFAP1
22 aortic aneurysm, familial thoracic 1 9.2 SMAD4 GATA5
23 duodenum cancer 9.2 SMAD4 PMS2 MUTYH AFAP1
24 duodenum disease 9.2 SMAD4 PMS2 MUTYH AFAP1
25 small intestine cancer 9.2 SMAD4 PMS2 MUTYH AFAP1
26 cell type benign neoplasm 9.2 SMAD4 MUTYH MIR483
27 cowden syndrome 9.2 SMAD4 PMS2 MUTYH AFAP1
28 lynch syndrome 9.2 SMAD4 PMS2 MUTYH AFAP1
29 intestinal benign neoplasm 9.1 SMAD4 PMS2 MUTYH MIR483
30 li-fraumeni syndrome 9.1 SMAD4 PMS2 MUTYH MIR483

Graphical network of the top 20 diseases related to Gastrointestinal Adenoma:



Diseases related to Gastrointestinal Adenoma

Symptoms & Phenotypes for Gastrointestinal Adenoma

MGI Mouse Phenotypes related to Gastrointestinal Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 GATA5 PMS2 SMAD4 TFF2 XPNPEP1
2 endocrine/exocrine gland MP:0005379 9.43 AFAP1 GATA5 PMS2 SMAD4 TFF2 XPNPEP1
3 immune system MP:0005387 9.17 CCDC86 EVL GATA5 PMS2 SMAD4 TFF2

Drugs & Therapeutics for Gastrointestinal Adenoma

Search Clinical Trials , NIH Clinical Center for Gastrointestinal Adenoma

Genetic Tests for Gastrointestinal Adenoma

Anatomical Context for Gastrointestinal Adenoma

MalaCards organs/tissues related to Gastrointestinal Adenoma:

40
Colon

Publications for Gastrointestinal Adenoma

Articles related to Gastrointestinal Adenoma:

# Title Authors PMID Year
1
[Consensus on pathological diagnosis of gastrointestinal adenoma and benign epithelial polyps]. 61
31914527 2020
2
Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia. 61
26083576 2015
3
Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse. 61
16505954 2006
4
Pseudomyxoma peritonei arising from colonic polyps. 61
16765563 2006
5
An immunohistochemical study of P53 and Ki-67 in gastrointestinal adenoma and adenocarcinoma using tissue microarray. 61
16821616 2006
6
Gastrointestinal: adenoma of the ampulla of Vater. 61
12164969 2002

Variations for Gastrointestinal Adenoma

Expression for Gastrointestinal Adenoma

Search GEO for disease gene expression data for Gastrointestinal Adenoma.

Pathways for Gastrointestinal Adenoma

GO Terms for Gastrointestinal Adenoma

Biological processes related to Gastrointestinal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to BMP stimulus GO:0071773 9.16 SMAD4 GATA5
2 mismatch repair GO:0006298 8.96 PMS2 MUTYH
3 negative regulation of cardiac muscle hypertrophy GO:0010614 8.62 SMAD4 GATA5

Molecular functions related to Gastrointestinal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutSalpha complex binding GO:0032407 8.62 PMS2 MUTYH

Sources for Gastrointestinal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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