MCID: GST078
MIFTS: 35

Gastrointestinal Allergy

Categories: Immune diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal Allergy

MalaCards integrated aliases for Gastrointestinal Allergy:

Name: Gastrointestinal Allergy 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060502
UMLS 73 C0221034

Summaries for Gastrointestinal Allergy

Disease Ontology : 12 A hypersensitivity reaction type I disease located in the gastrointestinal tract.

MalaCards based summary : Gastrointestinal Allergy is related to schistosomiasis and pemphigoid gestationis. An important gene associated with Gastrointestinal Allergy is TSLP (Thymic Stromal Lymphopoietin), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drug Acidophilus has been mentioned in the context of this disorder. Affiliated tissues include testes, skin and breast, and related phenotypes are hematopoietic system and immune system

Related Diseases for Gastrointestinal Allergy

Diseases related to Gastrointestinal Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 27.7 CD79A IGHE IL4 IL5 RNASE3
2 pemphigoid gestationis 10.8 CCL11 IL5
3 enteropathy-associated t-cell lymphoma 10.8 CCL11 ITGAE
4 chronic meningitis 10.8 CCL11 IL5
5 ascaris lumbricoides infection 10.7 IL5 TSLP
6 vulvovaginitis 10.7 CCL11 CCL5
7 respiratory syncytial virus infectious disease 10.7 CCL5 IL5
8 loeffler endocarditis 10.6 IL5 RNASE3
9 papillary conjunctivitis 10.6 CCL11 IL4
10 esophagitis, eosinophilic, 1 10.6 CCL11 IL5 TSLP
11 paragonimiasis 10.6 IL5 RNASE3
12 esophagitis 10.5 CCL11 IL5 TSLP
13 blepharitis 10.5 CCL11 IL4
14 scleritis 10.5 IL4 IL5
15 cold urticaria 10.5 CMA1 RNASE3
16 trichinosis 10.5 IL4 IL5
17 apple allergy 10.5 IL4 IL5
18 non-suppurative otitis media 10.5 IL4 IL5
19 cercarial dermatitis 10.4 IL4 IL5
20 intestinal schistosomiasis 10.4 IL4 IL5
21 chronic tic disorder 10.4 IL4 IL5
22 cellulitis 10.4 IL5 RNASE3
23 eosinophilic gastroenteritis 10.4 CCL11 IL5 RNASE3
24 chronic interstitial cystitis 10.4 CD79A RNASE3
25 pneumonia 10.4 CCL11 CCL5 IL5
26 sinusitis 10.4 IL5 RNASE3
27 cryptosporidiosis 10.4 CCL11 CD79A
28 radiculopathy 10.3 CCL5 IL5
29 anisakiasis 10.3 CD79A RNASE3
30 non-secretory myeloma 10.3 CD79A ITGAE
31 angiostrongyliasis 10.3 CCL11 IL4 IL5
32 eosinophilic meningitis 10.3 CCL11 IL4 IL5
33 immunoglobulin a deficiency 1 10.3 CD79A IL4
34 congenital hypogammaglobulinemia 10.3 CD79A IL4
35 inclusion conjunctivitis 10.3 CCL5 CD79A
36 status asthmaticus 10.3 CCL5 IL5 RNASE3
37 allergic contact dermatitis 10.3 IL33 IL4 IL5
38 parasitic ichthyosporea infectious disease 10.2 CD79A IL4
39 strongyloidiasis 10.2 CCL11 CD79A IL5
40 urticaria 10.2 AOC1 CMA1 RNASE3
41 rhinosporidiosis 10.2 CD79A IL4
42 toxocariasis 10.2 IGHE RNASE3
43 giant papillary conjunctivitis 10.2 CCL11 IL4 RNASE3
44 pulmonary disease, chronic obstructive 10.2 CCL11 CCL5 RNASE3
45 microscopic colitis 10.1 CD79A IL4
46 cough variant asthma 10.1 IL4 IL5 RNASE3
47 inflammatory bowel disease 4 10.1 IL4 IL5 RNASE3
48 intrinsic asthma 10.1 IL4 IL5 RNASE3
49 urinary schistosomiasis 10.1 IL4 IL5 RNASE3
50 exercise-induced anaphylaxis 10.1 CD79A IGHE

Graphical network of the top 20 diseases related to Gastrointestinal Allergy:



Diseases related to Gastrointestinal Allergy

Symptoms & Phenotypes for Gastrointestinal Allergy

MGI Mouse Phenotypes related to Gastrointestinal Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 IL4 IL5 ITGAE TSLP AOC1 CCL11
2 immune system MP:0005387 9.65 IL4 IL5 ITGAE TSLP CCL11 CCL5
3 respiratory system MP:0005388 9.1 IL4 IL5 TSLP CCL11 CRLF2 IL33

Drugs & Therapeutics for Gastrointestinal Allergy

Drugs for Gastrointestinal Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acidophilus Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Primary Prevention of Allergic Disease in Early Child by Lactobacillus Reuteri Completed NCT01285830 Phase 2
2 Study to Identify Non-Invasive Markers of Gastrointestinal Allergy Completed NCT00272818

Search NIH Clinical Center for Gastrointestinal Allergy

Genetic Tests for Gastrointestinal Allergy

Anatomical Context for Gastrointestinal Allergy

MalaCards organs/tissues related to Gastrointestinal Allergy:

41
Testes, Skin, Breast

Publications for Gastrointestinal Allergy

Articles related to Gastrointestinal Allergy:

(show all 24)
# Title Authors Year
1
IL-33 promotes gastrointestinal allergy in a TSLP-independent manner. ( 28656964 )
2018
2
IL-33 promotes gastrointestinal allergy in a TSLP-independent manner. ( 29067997 )
2017
3
Effect of raw milk on allergic responses in a murine model of gastrointestinal allergy. ( 24870507 )
2014
4
Dietary elimination of children with food protein induced gastrointestinal allergy - micronutrient adequacy with and without a hypoallergenic formula? ( 25328667 )
2014
5
Guidance for the nutrition management of gastrointestinal allergy in pediatrics. ( 24565537 )
2013
6
Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance. ( 20600023 )
2010
7
Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens. ( 16890767 )
2006
8
Gastrointestinal allergy in adults. ( 16292080 )
2005
9
Revisiting the "hygiene hypothesis" in gastrointestinal allergy. ( 17033352 )
2002
10
Gastrointestinal allergy: clinical symptoms and immunological mechanisms. ( 11380898 )
2001
11
A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. ( 10841566 )
2000
12
The involvement of the histamine degradation pathway by diamine oxidase in manifest gastrointestinal allergies. ( 10350171 )
1999
13
Anti-schistosomal IgE and its relation to gastrointestinal allergy in breast-fed infants of Schistosoma mansoni infected mothers. ( 9707682 )
1998
14
Gastrointestinal allergy to food: a review. ( 9661317 )
1997
15
Analysis and characteristics of mast cell tryptase and eosinophilic cationic protein from human gut mucosa in gastrointestinal allergy. ( 8813193 )
1996
16
Gastrointestinal allergy. ( 7975041 )
1994
17
Food allergens as causative factors of respiratory, skin and gastrointestinal allergy confirmed by skin prick test and specific IgE and IgG4 FAST in children. ( 1292838 )
1992
18
Malrotation in children with symptoms of gastrointestinal allergy and psychosomatic abdominal pain. ( 3993380 )
1985
19
Cromolyn in combined gastrointestinal allergy. ( 6771419 )
1980
20
Childhood gastrointestinal allergy: forbidden fruits. ( 6902927 )
1980
21
Use of cromolyn in combined gastrointestinal allergy. ( 112265 )
1979
22
Gastrointestinal allergy to soyabean protein in preruminant calves. Allergenic constituents of soyabean products. ( 575571 )
1979
23
Gastrointestinal allergy to soyabean protein in preruminant calves. Antibody production and digestive disturbances in calves fed heated soyabean flour. ( 575570 )
1979
24
Protein-losing enteropathy associated with gastrointestinal allergy. ( 4168025 )
1967

Variations for Gastrointestinal Allergy

Expression for Gastrointestinal Allergy

Search GEO for disease gene expression data for Gastrointestinal Allergy.

Pathways for Gastrointestinal Allergy

Pathways related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 AOC1 CCL11 CCL5 CD79A IGHE IL33
2
Show member pathways
13.42 CCL11 CCL5 CRLF2 IL33 IL4 IL5
3
Show member pathways
13.08 CCL11 CCL5 IGHE IL33 IL4 IL5
4
Show member pathways
12.3 CRLF2 IL4 IL5 TSLP
5
Show member pathways
12.27 CD79A IGHE IL4 IL5
6
Show member pathways
11.82 CCL11 CCL5 IL4 IL5
7 11.72 CD79A IL4 IL5
8 11.69 CCL11 IGHE IL4
9 11.42 CCL11 IGHE IL4 IL5
10 11.35 CCL11 CCL5 CMA1 IL4 IL5
11 11.22 CCL11 CRLF2 TSLP
12 11.06 IL33 IL4 IL5 TSLP
13 11.03 IL4 IL5
14 11.02 CCL11 CRLF2 IL33 IL4 IL5
15 11 CRLF2 IL33 IL4 IL5 ITGAE TSLP
16 10.96 IL4 IL5

GO Terms for Gastrointestinal Allergy

Cellular components related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 AOC1 CCL11 CCL5 CMA1 IL33 IL4
2 extracellular region GO:0005576 9.4 AOC1 CCL11 CCL5 CMA1 CRLF2 IGHE

Biological processes related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 CCL11 CCL5 CMA1 IGHE IL4 IL5
2 regulation of signaling receptor activity GO:0010469 9.63 CCL11 CCL5 IL33 IL4 IL5 TSLP
3 B cell activation GO:0042113 9.54 CD79A IL4
4 interleukin-7-mediated signaling pathway GO:0038111 9.52 CRLF2 TSLP
5 positive regulation of JAK-STAT cascade GO:0046427 9.51 CCL5 IL5
6 eosinophil chemotaxis GO:0048245 9.49 CCL11 CCL5
7 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL33 IL5
8 positive regulation of interleukin-5 production GO:0032754 9.46 IL33 TSLP
9 positive regulation of interleukin-5 secretion GO:2000664 9.43 CRLF2 TSLP
10 type 2 immune response GO:0042092 9.4 IL33 IL4
11 positive regulation of mast cell activation GO:0033005 9.37 CRLF2 TSLP
12 positive regulation of STAT cascade GO:1904894 9.32 CRLF2 TSLP
13 positive regulation of interleukin-13 production GO:0032736 9.13 IL33 IL4 TSLP
14 cytokine-mediated signaling pathway GO:0019221 9.1 CCL11 CCL5 CRLF2 IGHE IL4 IL5

Molecular functions related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL11 CCL5 IL33 IL4 IL5 TSLP
2 CCR chemokine receptor binding GO:0048020 8.96 CCL11 CCL5

Sources for Gastrointestinal Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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