MCID: GST071
MIFTS: 39

Gastrointestinal Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal Carcinoma

MalaCards integrated aliases for Gastrointestinal Carcinoma:

Name: Gastrointestinal Carcinoma 12 29 55 6 15 73
Gastrointestinal Neoplasms 73
Gastrointestinal Neoplasm 76

Classifications:



External Ids:

Disease Ontology 12 DOID:0050922
UMLS 73 C0151544

Summaries for Gastrointestinal Carcinoma

Disease Ontology : 12 A gastrointestinal system cancer that has material basis in epithelial cells.

MalaCards based summary : Gastrointestinal Carcinoma, also known as gastrointestinal neoplasms, is related to gastrointestinal system cancer and dihydropyrimidine dehydrogenase deficiency, and has symptoms including signs and symptoms, digestive An important gene associated with Gastrointestinal Carcinoma is EPCAM (Epithelial Cell Adhesion Molecule), and among its related pathways/superpathways are DNA Damage and O-linked glycosylation. The drugs Bevacizumab and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and lung.

Wikipedia : 76 Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and... more...

Related Diseases for Gastrointestinal Carcinoma

Diseases related to Gastrointestinal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 gastrointestinal system cancer 31.3 EPCAM MUC2 TYMS
2 dihydropyrimidine dehydrogenase deficiency 10.6 DPYD TYMS
3 chondroid chordoma 10.6 EPCAM MUC1
4 mucinous bronchioloalveolar adenocarcinoma 10.6 KRT20 MUC1
5 paget disease, extramammary 10.6 KRT20 MUC1
6 villous adenoma 10.6 KRT20 MUC1
7 lymphoepithelioma-like carcinoma 10.5 KRT20 MUC1
8 dermoid cyst 10.5 KRT20 MUC1
9 cystadenofibroma 10.5 KRT20 MUC1
10 cholangiolocellular carcinoma 10.5 ABCB1 MUC1
11 dendritic cell tumor 10.5 KRT20 MUC1
12 plasmablastic lymphoma 10.4 ABCB1 MUC1
13 mammary paget's disease 10.4 KRT20 MUC1
14 rectal neoplasm 10.3 DPYD KRT20 TYMS
15 benign mesothelioma 10.3 KRT20 MUC1 TYMS
16 mucositis 10.3 ABCB1 DPYD TYMS
17 acute lymphoblastic leukemia, childhood 10.2 ABCB1 TYMS
18 colon adenocarcinoma 10.2 ABCB1 KRT20 TYMS
19 pancreatic intraductal papillary-mucinous neoplasm 10.0 MUC1 MUC2
20 tumor of exocrine pancreas 10.0 MUC1 MUC2
21 bile duct mucoepidermoid carcinoma 10.0 MUC1 MUC2
22 chronic ethmoiditis 10.0 MUC1 MUC2
23 tn polyagglutination syndrome 10.0 MUC1 MUC2
24 mucinous tubular and spindle renal cell carcinoma 10.0 MUC1 MUC2
25 ethmoid sinusitis 10.0 MUC1 MUC2
26 polycystic liver disease 1 with or without kidney cysts 10.0 KRT20 MUC1
27 colloid carcinoma of the pancreas 10.0 MUC1 MUC2
28 adenoid cystic carcinoma 10.0 CHEK2 KRT20 MUC1
29 ovarian mucinous neoplasm 10.0 KRT20 MUC2
30 cystic teratoma 9.9 KRT20 MUC2
31 meconium ileus 9.9 MUC1 MUC2
32 biliary tract neoplasm 9.9 MUC1 MUC2
33 duodenum cancer 9.9 MUC1 MUC2
34 cystitis cystica 9.9 KRT20 MUC2
35 gastric tubular adenocarcinoma 9.8 MUC1 MUC2
36 papillary adenocarcinoma 9.8 MUC1 MUC2
37 renal cell carcinoma, nonpapillary 9.8 ABCB1 EPCAM KRT20 MUC1
38 small intestine cancer 9.8 KRT20 MUC2
39 small intestinal adenocarcinoma 9.8 MUC1 MUC2
40 colorectal cancer 1 9.7 MUC1 MUC2
41 bile duct adenocarcinoma 9.7 EPCAM MUC1 MUC2
42 intrahepatic cholangiocarcinoma 9.7 EPCAM MUC1 MUC2
43 bile duct cystadenocarcinoma 9.7 KRT20 MUC1 MUC2
44 ampulla of vater neoplasm 9.7 KRT20 MUC1 MUC2
45 appendix cancer 9.7 KRT20 MUC1 MUC2
46 ampulla of vater adenocarcinoma 9.7 KRT20 MUC1 MUC2
47 mucinous cystadenocarcinoma 9.7 KRT20 MUC1 MUC2
48 biliary papillomatosis 9.7 KRT20 MUC1 MUC2
49 pancreatic mucinous cystadenoma 9.7 KRT20 MUC1 MUC2
50 pseudomyxoma peritonei 9.7 KRT20 MUC1 MUC2

Graphical network of the top 20 diseases related to Gastrointestinal Carcinoma:



Diseases related to Gastrointestinal Carcinoma

Symptoms & Phenotypes for Gastrointestinal Carcinoma

UMLS symptoms related to Gastrointestinal Carcinoma:


signs and symptoms, digestive

Drugs & Therapeutics for Gastrointestinal Carcinoma

Drugs for Gastrointestinal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Oxaliplatin Approved, Investigational Phase 2,Not Applicable 61825-94-3 5310940 9887054 43805 6857599
3 Angiogenesis Inhibitors Phase 2,Phase 1
4 Angiogenesis Modulating Agents Phase 2,Phase 1
5
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
6 Protein Kinase Inhibitors Phase 2
7
s 1 (combination) Phase 2
8
Cetuximab Approved Phase 1 205923-56-4 56842117 2333
9
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
10
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
11
Xylometazoline Approved, Investigational Phase 1 526-36-3 5709
12 Alkylating Agents Phase 1
13 Analgesics Phase 1
14 Analgesics, Non-Narcotic Phase 1
15 Antimetabolites Phase 1
16 Antimetabolites, Antineoplastic Phase 1
17 Antineoplastic Agents, Alkylating Phase 1
18 Antirheumatic Agents Phase 1
19 Immunosuppressive Agents Phase 1
20 Interleukin-2 Phase 1
21 Peripheral Nervous System Agents Phase 1
22 Adjuvants, Immunologic Phase 1
23 Interleukin-12 Phase 1
24 Complement Factor B Phase 1
25 Endothelial Growth Factors Phase 1
26 Mitogens Phase 1
27 Cola Nutraceutical Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Avastin and Tarceva for Upper Gastrointestinal Cancers Completed NCT00350753 Phase 2 Erlotinib and bevacizumab
2 Study of DPD for Predicting Efficacy and Safety to S-1 Plus Oxaliplatin in Gastrointestinal Cancer Recruiting NCT01608646 Phase 2 S-1 plus oxaliplatin
3 Study to Assess the Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations Recruiting NCT02795156 Phase 2 afatinib;regorafenib;Cabozantinib
4 Allogenic Immunotherapy Based on Natural Killer (NK) Cell Adoptive Transfer in Metastatic Gastrointestinal Carcinoma Treated With Cetuximab Completed NCT02845999 Phase 1 Cyclophosphamide;fludarabine;interleukin-2
5 Interleukin-12 in Treating Patients With Cancer in the Abdomen Completed NCT00003046 Phase 1
6 Ganetespib and Ziv-Aflibercept in Refractory Gastrointestinal Carcinomas, Non-Squamous Non-Small Cell Lung Carcinomas, Urothelial Carcinomas, and Sarcomas Terminated NCT02192541 Phase 1 Ziv-Aflibercept;Ganetespib
7 MLN0264 in Previously Treated Asian Participants With Advanced Gastrointestinal Carcinoma or Metastatic or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Guanylyl Cyclase C Terminated NCT02391038 Phase 1 MLN0264
8 Continuous Activity Monitoring During Fractionated Radiotherapy in Patients With Head and Neck, Lung, or Gastrointestinal Cancer Completed NCT02649569
9 Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma Recruiting NCT01048281
10 Web-based Mindfulness Meditation in Reducing Distress in Participants With Metastatic Gastrointestinal Cancer and Their Caregivers Recruiting NCT03528863 Not Applicable
11 Clinical Trial of Electroacupuncture Stimulation on Prevention and Treatment of Oxaliplatin Neurotoxicity Recruiting NCT03330964 Not Applicable
12 Narrow Band Imaging (NBI): A Novel Imaging Modality in Minimally Invasive Active, not recruiting NCT01262040 Not Applicable
13 Clinical Trial on Acupuncture Adjuvant Treatment in the Pain After the Surgery of Gastrointestinal Carcinoma Not yet recruiting NCT02871999 Not Applicable
14 Detection of MicroRNA-25 in the Diagnosis of Pancreatic Cancer Not yet recruiting NCT03432624

Search NIH Clinical Center for Gastrointestinal Carcinoma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Gastrointestinal Carcinoma

Genetic tests related to Gastrointestinal Carcinoma:

# Genetic test Affiliating Genes
1 Gastrointestinal Carcinoma 29

Anatomical Context for Gastrointestinal Carcinoma

MalaCards organs/tissues related to Gastrointestinal Carcinoma:

41
Small Intestine, Pancreas, Lung, Nk Cells, Endothelial, Lymph Node, Liver

Publications for Gastrointestinal Carcinoma

Articles related to Gastrointestinal Carcinoma:

(show top 50) (show all 86)
# Title Authors Year
1
Immunotherapy in Gastrointestinal Carcinoma - How to Separate Hope from Hype. ( 29705785 )
2018
2
In situ delivery of allogeneic natural killer cell (NK) combined with Cetuximab in liver metastases of gastrointestinal carcinoma: A phase I clinical trial. ( 29721386 )
2018
3
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma. ( 29723071 )
2018
4
Outlook: Immunotherapy in Gastrointestinal Carcinoma - Innovative Strategies. ( 29705792 )
2018
5
TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-label, Non-randomized Phase 1 Study. ( 28494535 )
2017
6
Advanced gastrointestinal carcinoma with massive ascites and hydrothorax during pregnancy: A case report and review of the literature. ( 29390520 )
2017
7
Osteoprotegerin: A novel biomarker for inflammatory bowel disease and gastrointestinal carcinoma. ( 26896745 )
2016
8
Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine. ( 26436698 )
2015
9
Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. ( 25364431 )
2014
10
Immunohistochemical expression of nuclear and cytoplasmic survivin in gastrointestinal carcinoma. ( 24294379 )
2013
11
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). ( 23620673 )
2013
12
Ascites as the initial presentation of gastrointestinal carcinoma. ( 22766406 )
2013
13
Parenteral nutrition and preOp preparation in prevention of post-operative insulin resistance in gastrointestinal carcinoma. ( 23612677 )
2013
14
Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review). ( 24649035 )
2013
15
Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome. ( 23430953 )
2013
16
Comparison of 2 monoclonal antibodies for immunohistochemical detection of BRAF V600E mutation in malignant melanoma, pulmonary carcinoma, gastrointestinal carcinoma, thyroid carcinoma, and gliomas. ( 24071017 )
2013
17
Combination therapies with oxaliplatin and oral capecitabine or intravenous 5-FU show similar toxicity profiles in gastrointestinal carcinoma patients if hand-food syndrome prophylaxis is performed continuously. ( 22783416 )
2012
18
Young patient age as the cause of delayed diagnosis of gastrointestinal carcinoma. ( 22842745 )
2012
19
Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12. ( 21515097 )
2011
20
Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. ( 20202824 )
2010
21
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study. ( 20378407 )
2010
22
Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells. ( 19781661 )
2010
23
H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1. ( 19896696 )
2010
24
[Relationship of cyclooxygenase-2 and multidrug resistance associated factors to chemosensitivities in gastrointestinal carcinomas]. ( 20369487 )
2010
25
Multicenter randomized comparison of LigaSure versus conventional surgery for gastrointestinal carcinoma. ( 21046504 )
2010
26
Surgical management for a malignant bowel obstruction with recurrent gastrointestinal carcinoma. ( 20039277 )
2010
27
[Expression features of P-glycoprotein, glutathione S transferase-pi and inhibitor of apoptosis proteins in lymph node metastases of gastrointestinal carcinomas]. ( 19563003 )
2009
28
[Investigation of the presence of human papillomavirus DNA in various gastrointestinal carcinoma samples]. ( 19621611 )
2009
29
Modulation of key signal transduction molecules by a novel peptide combination effective for the treatment of gastrointestinal carcinomas. ( 18322652 )
2008
30
[Correlation of expression of P-glycoprotein and inhibitor of apoptosis proteins to chemosensitivity in gastrointestinal carcinoma tissues]. ( 19000447 )
2008
31
Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. ( 18566219 )
2008
32
Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas. ( 17636327 )
2008
33
[A comparison of the metabolic effect of postoperative analgesia with lornoxicam and morphine or morphine on patients undergoing gastrointestinal carcinoma operation]. ( 18344081 )
2008
34
Unsymmetrical DMH - an isomer of 1,2 DMH - is it potent to induce gastrointestinal carcinoma in rats? ( 18222660 )
2008
35
Novel clinical staging for patients with end-stage gastrointestinal carcinoma. ( 16378189 )
2006
36
Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas. ( 16328347 )
2006
37
Tissue-type plasminogen activator activity in morphologically normal tissues adjacent to gastrointestinal carcinomas is associated with the degree of tumor progression. ( 16369808 )
2006
38
Reliability and validity of a new scale to assess postoperative dysfunction after resection of upper gastrointestinal carcinoma. ( 15976949 )
2005
39
Prognostic impact of CK-20-positive cells in peripheral venous blood of patients with gastrointestinal carcinoma. ( 15770378 )
2005
40
Effects of 7.5% hypertonic saline on fluid balance after radical surgery for gastrointestinal carcinoma. ( 15786530 )
2005
41
Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas. ( 16061638 )
2005
42
[CK20 mRNA expression in peripheral blood of patients with gastrointestinal carcinoma and its clinical significance]. ( 15522189 )
2004
43
Relationship between immunohistochemical evaluation of thymidylate synthase and proliferating cell nuclear antigen labeling index in gastrointestinal carcinoma. ( 15547732 )
2004
44
Rapid immunohistochemical detection of lymph node micrometastasis during operation for upper gastrointestinal carcinoma. ( 12734863 )
2003
45
Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. ( 14525978 )
2003
46
Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options. ( 12790326 )
2003
47
Expression of cell adhesion molecules, their ligands and tumour necrosis factor alpha in the liver of patients with metastatic gastrointestinal carcinomas. ( 12365802 )
2002
48
Circadian variation of dihydropyrimidine dehydrogenase mRNA expression in leukocytes and serum cortisol levels in patients with advanced gastrointestinal carcinomas compared to healthy controls. ( 11862480 )
2002
49
Impact of thrombophilic gene mutations on thrombosis risk in patients with gastrointestinal carcinoma. ( 12115343 )
2002
50
Variant WISPs as targets for gastrointestinal carcinomas. ( 12105881 )
2002

Variations for Gastrointestinal Carcinoma

ClinVar genetic disease variations for Gastrointestinal Carcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHEK2 NM_007194.3(CHEK2): c.470T> C (p.Ile157Thr) single nucleotide variant risk factor rs17879961 GRCh37 Chromosome 22, 29121087: 29121087
2 CHEK2 NM_007194.3(CHEK2): c.470T> C (p.Ile157Thr) single nucleotide variant risk factor rs17879961 GRCh38 Chromosome 22, 28725099: 28725099
3 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh37 Chromosome 7, 73466262: 73466262
4 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh38 Chromosome 7, 74051932: 74051932

Copy number variations for Gastrointestinal Carcinoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19435 1 150300000 155000000 Amplification Gastrointestinal cancer
2 119187 18 1 2900000 LOH TS Gastrointestinal cancer
3 119685 18 16100000 23300000 Deletion HRH4 Gastrointestinal cancer

Expression for Gastrointestinal Carcinoma

Search GEO for disease gene expression data for Gastrointestinal Carcinoma.

Pathways for Gastrointestinal Carcinoma

GO Terms for Gastrointestinal Carcinoma

Cellular components related to Gastrointestinal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 ABCB1 EPCAM MUC1

Biological processes related to Gastrointestinal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 CHEK2 MUC1
2 O-glycan processing GO:0016266 8.8 MUC1 MUC2 ST3GAL3

Sources for Gastrointestinal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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