MCID: GST071
MIFTS: 43

Gastrointestinal Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal Carcinoma

MalaCards integrated aliases for Gastrointestinal Carcinoma:

Name: Gastrointestinal Carcinoma 12 29 55 6 15 73
Gastrointestinal Neoplasms 73
Gastrointestinal Neoplasm 76

Classifications:



External Ids:

Disease Ontology 12 DOID:0050922

Summaries for Gastrointestinal Carcinoma

Disease Ontology : 12 A gastrointestinal system cancer that has material basis in epithelial cells.

MalaCards based summary : Gastrointestinal Carcinoma, also known as gastrointestinal neoplasms, is related to mammary paget's disease and colorectal cancer, and has symptoms including signs and symptoms, digestive An important gene associated with Gastrointestinal Carcinoma is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Cytoskeletal Signaling and DNA Damage. The drugs Oxaliplatin and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and small intestine.

Wikipedia : 76 Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and... more...

Related Diseases for Gastrointestinal Carcinoma

Diseases related to Gastrointestinal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 mammary paget's disease 29.7 KRT20 MUC1
2 colorectal cancer 28.7 ABCB1 CHEK2 DPYD EPCAM KRT20 MUC1
3 gastrointestinal system cancer 11.2
4 dihydropyrimidine dehydrogenase deficiency 10.2 DPYD TYMS
5 chondroid chordoma 10.2 EPCAM MUC1
6 bile duct cystadenocarcinoma 10.2 KRT20 MUC1
7 bile duct adenoma 10.2 KRT20 MUC1
8 mucinous adenocarcinoma 10.2 KRT20 MUC1
9 paget disease, extramammary 10.2 KRT20 MUC1
10 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT20 MUC1
11 ampulla of vater adenocarcinoma 10.1 KRT20 MUC1
12 biliary papillomatosis 10.1 KRT20 MUC1
13 villous adenoma 10.1 KRT20 MUC1
14 lymphoepithelioma-like carcinoma 10.1 KRT20 MUC1
15 ovarian mucinous adenocarcinoma 10.1 ABCB1 KRT20
16 dermoid cyst 10.1 KRT20 MUC1
17 cystadenofibroma 10.1 KRT20 MUC1
18 mucinous cystadenocarcinoma 10.1 KRT20 MUC1
19 gastric cardia carcinoma 10.1 MUC1 TYMS
20 appendix cancer 10.1 KRT20 MUC1
21 cholangiolocellular carcinoma 10.1 ABCB1 MUC1
22 pancreatic mucinous cystadenoma 10.1 KRT20 MUC1
23 cystadenoma 10.1 KRT20 MUC1
24 dendritic cell tumor 10.1 KRT20 MUC1
25 plasmablastic lymphoma 10.1 ABCB1 MUC1
26 brachydactyly, type e1 10.1 KRT20 MUC1
27 bile duct adenocarcinoma 10.1 EPCAM MUC1
28 pseudomyxoma peritonei 10.1 KRT20 MUC1
29 signet ring cell adenocarcinoma 10.1 KRT20 MUC1
30 tubular adenocarcinoma 10.1 KRT20 MUC1
31 ampulla of vater cancer 10.1 KRT20 MUC1
32 rectal neoplasm 10.1 DPYD KRT20 TYMS
33 pancreatic ductal carcinoma 10.1 KRT20 MUC1
34 dysgerminoma 10.1 KRT20 MUC1
35 cavernous hemangioma 10.0 KRT20 MUC1
36 mucositis 10.0 ABCB1 DPYD TYMS
37 mesothelioma, malignant 10.0 KRT20 MUC1 TYMS
38 polycystic liver disease 1 with or without kidney cysts 10.0 KRT20 MUC1
39 adenoid cystic carcinoma 10.0 CHEK2 KRT20 MUC1
40 colon adenocarcinoma 10.0 ABCB1 KRT20 TYMS
41 merkel cell carcinoma 10.0 KRT20 MUC1
42 malignant pleural mesothelioma 10.0 MUC1 TYMS
43 gastric adenocarcinoma 9.9 EPCAM KRT20 MUC1 TYMS
44 esophageal cancer 9.9 CHEK2 DPYD MUC1 TYMS
45 fuchs' endothelial dystrophy 9.9 KRT20 MUC1
46 renal cell carcinoma, nonpapillary 9.9 ABCB1 EPCAM KRT20 MUC1
47 peutz-jeghers syndrome 9.7
48 familial adenomatous polyposis 9.7
49 hepatocellular carcinoma 9.6
50 insulin-like growth factor i 9.6

Graphical network of the top 20 diseases related to Gastrointestinal Carcinoma:



Diseases related to Gastrointestinal Carcinoma

Symptoms & Phenotypes for Gastrointestinal Carcinoma

UMLS symptoms related to Gastrointestinal Carcinoma:


signs and symptoms, digestive

Drugs & Therapeutics for Gastrointestinal Carcinoma

Drugs for Gastrointestinal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2,Not Applicable 61825-94-3 43805 6857599 5310940 9887054
2
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
3
s 1 (combination) Phase 2
4
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
5 Angiogenesis Modulating Agents Phase 2,Phase 1
6 Protein Kinase Inhibitors Phase 2
7 Angiogenesis Inhibitors Phase 2,Phase 1
8
Cyclophosphamide Approved, Investigational Phase 1 6055-19-2, 50-18-0 2907
9
Fludarabine Approved Phase 1 75607-67-9, 21679-14-1 30751
10
Cetuximab Approved Phase 1 205923-56-4 56842117 2333
11
Sirolimus Approved, Investigational Phase 1 53123-88-9 46835353 6436030 5284616
12
Everolimus Approved Phase 1 159351-69-6 6442177
13
Valproic Acid Approved, Investigational Phase 1 99-66-1 3121
14
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
15
Aldesleukin Approved Phase 1 85898-30-2, 110942-02-4
16
Pembrolizumab Approved Phase 1 1374853-91-4
17
Xylometazoline Approved, Investigational Phase 1 526-36-3 5709
18 Interleukin-2 Phase 1
19 Antineoplastic Agents, Alkylating Phase 1
20 Alkylating Agents Phase 1
21 Antimetabolites, Antineoplastic Phase 1
22 Antimetabolites Phase 1
23 Immunosuppressive Agents Phase 1
24 Antirheumatic Agents Phase 1
25 Peripheral Nervous System Agents Phase 1
26 Immunologic Factors Phase 1
27 Analgesics, Non-Narcotic Phase 1
28 Analgesics Phase 1
29 Cola Phase 1
30 Adjuvants, Immunologic Phase 1
31 Interleukin-12 Phase 1
32 Immunoglobulin G Phase 1
33 GABA Agents Phase 1
34 Psychotropic Drugs Phase 1
35 Central Nervous System Depressants Phase 1
36 Antibiotics, Antitubercular Phase 1
37 Anti-Bacterial Agents Phase 1
38 Endothelial Growth Factors Phase 1
39 Tranquilizing Agents Phase 1
40 Antifungal Agents Phase 1
41 Antibodies, Monoclonal Phase 1
42 Antimanic Agents Phase 1
43 Anticonvulsants Phase 1
44 Mitogens Phase 1
45 Neurotransmitter Agents Phase 1
46 Antibodies Phase 1
47 Anti-Infective Agents Phase 1
48 Immunoglobulins Phase 1
49 Anti-HIV Agents Phase 1
50 Antiviral Agents Phase 1

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Study of DPD for Predicting Efficacy and Safety to S-1 Plus Oxaliplatin in Gastrointestinal Cancer Unknown status NCT01608646 Phase 2 S-1 plus oxaliplatin
2 Avastin and Tarceva for Upper Gastrointestinal Cancers Completed NCT00350753 Phase 2 Erlotinib and bevacizumab
3 Study to Assess the Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations Recruiting NCT02795156 Phase 2 afatinib;regorafenib;Cabozantinib
4 Allogenic Immunotherapy Based on Natural Killer (NK) Cell Adoptive Transfer in Metastatic Gastrointestinal Carcinoma Treated With Cetuximab Completed NCT02845999 Phase 1 Cyclophosphamide;fludarabine;interleukin-2
5 Interleukin-12 in Treating Patients With Cancer in the Abdomen Completed NCT00003046 Phase 1
6 Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease Recruiting NCT01552434 Phase 1 Temsirolimus;Valproic Acid
7 CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors Not yet recruiting NCT02757391 Phase 1 Cyclophosphamide
8 Ganetespib and Ziv-Aflibercept in Refractory Gastrointestinal Carcinomas, Non-Squamous Non-Small Cell Lung Carcinomas, Urothelial Carcinomas, and Sarcomas Terminated NCT02192541 Phase 1 Ziv-Aflibercept;Ganetespib
9 MLN0264 in Previously Treated Asian Participants With Advanced Gastrointestinal Carcinoma or Metastatic or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Guanylyl Cyclase C Terminated NCT02391038 Phase 1 MLN0264
10 Clinical Trial on Acupuncture Adjuvant Treatment in the Pain After the Surgery of Gastrointestinal Carcinoma Completed NCT02871999 Not Applicable
11 Continuous Activity Monitoring During Fractionated Radiotherapy in Patients With Head and Neck, Lung, or Gastrointestinal Cancer Completed NCT02649569
12 Narrow Band Imaging (NBI): A Novel Imaging Modality in Minimally Invasive Completed NCT01262040 Not Applicable
13 Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma Recruiting NCT01048281
14 Web-based Mindfulness Meditation in Reducing Distress in Participants With Metastatic Gastrointestinal Cancer and Their Caregivers Recruiting NCT03528863 Not Applicable
15 Clinical Trial of Electroacupuncture Stimulation on Prevention and Treatment of Oxaliplatin Neurotoxicity Recruiting NCT03330964 Not Applicable
16 Detection of MicroRNA-25 in the Diagnosis of Pancreatic Cancer Not yet recruiting NCT03432624

Search NIH Clinical Center for Gastrointestinal Carcinoma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Gastrointestinal Carcinoma

Genetic tests related to Gastrointestinal Carcinoma:

# Genetic test Affiliating Genes
1 Gastrointestinal Carcinoma 29

Anatomical Context for Gastrointestinal Carcinoma

MalaCards organs/tissues related to Gastrointestinal Carcinoma:

41
Pancreas, Testes, Small Intestine, Colon, Liver, Lung, Skin

Publications for Gastrointestinal Carcinoma

Articles related to Gastrointestinal Carcinoma:

(show top 50) (show all 208)
# Title Authors Year
1
Immunotherapy in Gastrointestinal Carcinoma - How to Separate Hope from Hype. ( 29705785 )
2018
2
In situ delivery of allogeneic natural killer cell (NK) combined with Cetuximab in liver metastases of gastrointestinal carcinoma: A phase I clinical trial. ( 29721386 )
2018
3
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma. ( 29723071 )
2018
4
Outlook: Immunotherapy in Gastrointestinal Carcinoma - Innovative Strategies. ( 29705792 )
2018
5
The incidence and risk factors of hepatotoxicity induced by perioperative hyperthermic intraperitoneal chemotherapy in gastrointestinal carcinoma patients: a retrospective study. ( 30254464 )
2018
6
A novel gel immersion technique using a bipolar needle-knife in endoscopic submucosal dissection for superficial gastrointestinal neoplasms. ( 29507476 )
2018
7
TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-label, Non-randomized Phase 1 Study. ( 28494535 )
2017
8
Advanced gastrointestinal carcinoma with massive ascites and hydrothorax during pregnancy: A case report and review of the literature. ( 29390520 )
2017
9
Comparison of endoscopic ultrasonography and magnifying endoscopy for assessment of the invasion depth of shallow gastrointestinal neoplasms: a systematic review and meta-analysis. ( 28547665 )
2017
10
Biomedical optical spectroscopy for the early diagnosis of gastrointestinal neoplasms. ( 28671054 )
2017
11
Osteoprotegerin: A novel biomarker for inflammatory bowel disease and gastrointestinal carcinoma. ( 26896745 )
2016
12
Fecal Recovery of Ingested Cellular DNA: Implications for Noninvasive Detection of Upper Gastrointestinal Neoplasms. ( 26297132 )
2016
13
Clinical outcomes and toxicities of proton radiotherapy for gastrointestinal neoplasms: a systematic review. ( 27563457 )
2016
14
Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine. ( 26436698 )
2015
15
Conventional radiological strategy of common gastrointestinal neoplasms. ( 25628800 )
2015
16
Usefulness of Ready-to-Use 0.4% Sodium Hyaluronate (Endo-Ease) in the Endoscopic Resection of Gastrointestinal Neoplasms. ( 26473122 )
2015
17
Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. ( 25364431 )
2014
18
Targeted lymph node assessment in gastrointestinal neoplasms. ( 24331086 )
2014
19
Treating scar tissues during endoscopic submucosal dissection for gastrointestinal neoplasms. ( 25314172 )
2014
20
Immunohistochemical expression of nuclear and cytoplasmic survivin in gastrointestinal carcinoma. ( 24294379 )
2013
21
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). ( 23620673 )
2013
22
Ascites as the initial presentation of gastrointestinal carcinoma. ( 22766406 )
2013
23
Parenteral nutrition and preOp preparation in prevention of post-operative insulin resistance in gastrointestinal carcinoma. ( 23612677 )
2013
24
Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review). ( 24649035 )
2013
25
Comparison of 2 monoclonal antibodies for immunohistochemical detection of BRAF V600E mutation in malignant melanoma, pulmonary carcinoma, gastrointestinal carcinoma, thyroid carcinoma, and gliomas. ( 24071017 )
2013
26
The accumulating appreciation of endoscopic submucosal dissection in the treatment of gastrointestinal neoplasms: preliminary experience in local eastern China. ( 23425807 )
2013
27
Contributions of molecular analysis to the diagnosis and treatment of gastrointestinal neoplasms. ( 24342289 )
2013
28
Combination therapies with oxaliplatin and oral capecitabine or intravenous 5-FU show similar toxicity profiles in gastrointestinal carcinoma patients if hand-food syndrome prophylaxis is performed continuously. ( 22783416 )
2012
29
Young patient age as the cause of delayed diagnosis of gastrointestinal carcinoma. ( 22842745 )
2012
30
The impact of incidental gastrointestinal stromal tumours on patients undergoing resection of upper gastrointestinal neoplasms. ( 22992402 )
2012
31
Recent advances in targeted endoscopic imaging: Early detection of gastrointestinal neoplasms. ( 22442742 )
2012
32
Endoscopic submucosal dissection for removal of superficial gastrointestinal neoplasms: A technical review. ( 22523613 )
2012
33
Splenic metastasis from gastrointestinal neoplasms: a review. ( 22567739 )
2012
34
Cutoff values of serum ferritin and TIBC saturation for the evaluation of gastrointestinal neoplasms in adult anemic patients. ( 22740376 )
2012
35
Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12. ( 21515097 )
2011
36
Ultraslim endoscopy with flexible spectral imaging color enhancement for upper gastrointestinal neoplasms. ( 21258601 )
2011
37
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study. ( 20378407 )
2010
38
Multicenter randomized comparison of LigaSure versus conventional surgery for gastrointestinal carcinoma. ( 21046504 )
2010
39
Surgical management for a malignant bowel obstruction with recurrent gastrointestinal carcinoma. ( 20039277 )
2010
40
[Investigation of the presence of human papillomavirus DNA in various gastrointestinal carcinoma samples]. ( 19621611 )
2009
41
[Correlation of expression of P-glycoprotein and inhibitor of apoptosis proteins to chemosensitivity in gastrointestinal carcinoma tissues]. ( 19000447 )
2008
42
[A comparison of the metabolic effect of postoperative analgesia with lornoxicam and morphine or morphine on patients undergoing gastrointestinal carcinoma operation]. ( 18344081 )
2008
43
Unsymmetrical DMH - an isomer of 1,2 DMH - is it potent to induce gastrointestinal carcinoma in rats? ( 18222660 )
2008
44
Extramammary Paget's disease in Korea: its association with gastrointestinal neoplasms. ( 18535830 )
2008
45
Application of immunohistochemistry to liver and gastrointestinal neoplasms: liver, stomach, colon, and pancreas. ( 18318589 )
2008
46
Endoscopic submucosal dissection for gastrointestinal neoplasms. ( 18494043 )
2008
47
Perspective on the practical indications of endoscopic submucosal dissection of gastrointestinal neoplasms. ( 18666315 )
2008
48
Correlation of endoscopic brush cytology with biopsy in diagnosis of upper gastrointestinal neoplasms. ( 19008572 )
2008
49
Technology insight: endoscopic submucosal dissection of gastrointestinal neoplasms. ( 17768396 )
2007
50
Novel clinical staging for patients with end-stage gastrointestinal carcinoma. ( 16378189 )
2006

Variations for Gastrointestinal Carcinoma

ClinVar genetic disease variations for Gastrointestinal Carcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHEK2 NM_007194.4(CHEK2): c.470T> C (p.Ile157Thr) single nucleotide variant risk factor rs17879961 GRCh37 Chromosome 22, 29121087: 29121087
2 CHEK2 NM_007194.4(CHEK2): c.470T> C (p.Ile157Thr) single nucleotide variant risk factor rs17879961 GRCh38 Chromosome 22, 28725099: 28725099
3 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh37 Chromosome 7, 73466262: 73466262
4 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh38 Chromosome 7, 74051932: 74051932

Copy number variations for Gastrointestinal Carcinoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19435 1 150300000 155000000 Amplification Gastrointestinal cancer
2 119187 18 1 2900000 LOH TS Gastrointestinal cancer
3 119685 18 16100000 23300000 Deletion HRH4 Gastrointestinal cancer

Expression for Gastrointestinal Carcinoma

Search GEO for disease gene expression data for Gastrointestinal Carcinoma.

Pathways for Gastrointestinal Carcinoma

Pathways related to Gastrointestinal Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 EPCAM KRT20 MUC1
2 11.8 CHEK2 DPYD TYMS
3 10.39 FUT6 ST3GAL3
4 9.98 ABCB1 CHEK2

GO Terms for Gastrointestinal Carcinoma

Cellular components related to Gastrointestinal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.13 ABCB1 EPCAM MUC1
2 extracellular exosome GO:0070062 9.1 ABCB1 EEF1G EPCAM FUT6 MUC1 PLOD1

Biological processes related to Gastrointestinal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 O-glycan processing GO:0016266 9.16 MUC1 ST3GAL3
2 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.96 CHEK2 MUC1
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.62 CHEK2 MUC1

Molecular functions related to Gastrointestinal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.92 CHEK2 DPYD PLOD1 TYMS

Sources for Gastrointestinal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....