MCID: GST014
MIFTS: 30

Gastrointestinal Lymphoma

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Gastrointestinal Lymphoma

MalaCards integrated aliases for Gastrointestinal Lymphoma:

Name: Gastrointestinal Lymphoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:903
NCIt 50 C38162
SNOMED-CT 67 449072004
UMLS 70 C0740372

Summaries for Gastrointestinal Lymphoma

MalaCards based summary : Gastrointestinal Lymphoma is related to gastric lymphoma and lymphoma, hodgkin, classic. An important gene associated with Gastrointestinal Lymphoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are NF-kappaB Signaling and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include colon, bone marrow and pancreas, and related phenotypes are hematopoietic system and immune system

Related Diseases for Gastrointestinal Lymphoma

Diseases related to Gastrointestinal Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 gastric lymphoma 30.5 MALT1 CD79A BCL6
2 lymphoma, hodgkin, classic 30.3 TNFRSF8 TIA1 BCL6
3 heavy chain disease 30.2 SERPINA3 CD79A
4 hodgkin's lymphoma, lymphocytic-histiocytic predominance 30.2 TNFRSF8 BCL6
5 lymphosarcoma 30.2 TNFRSF8 BCL6
6 nodal marginal zone lymphoma 30.0 SPN MME CD5 BCL6
7 follicular lymphoma 29.7 MME CD5 CCND1 BCL6
8 colon lymphoma 29.5 MME CD79A CD5 BCL6
9 adult lymphoma 29.5 TNFRSF8 MME CD5 BCL6
10 celiac disease 1 29.5 TIA1 NCAM1 CD79A
11 lymphoblastic lymphoma 29.5 TNFRSF8 MME CD5 BCL6
12 lymphoma 29.5 TNFRSF8 TIA1 MALT1 CD5 CCND1 BCL6
13 amyloidosis 29.5 SERPINA3 MME CCND1
14 b-cell lymphoma 29.3 TNFRSF8 TIA1 MME MALT1 CD5 CCND1
15 diffuse large b-cell lymphoma 28.9 TNFRSF8 SPN MME MALT1 CD79A CD5
16 mantle cell lymphoma 28.9 SPN MME MALT1 CD5 CCND1 BCL6
17 lymphoma, mucosa-associated lymphoid type 28.6 TNFRSF8 SPN MME MALT1 CD79A CD5
18 marginal zone b-cell lymphoma 28.6 TNFRSF8 SPN MME MALT1 CD79A CD5
19 alpha chain disease 28.5 SPN MALT1 CD79A CD5 CCND1 BCL6
20 peripheral t-cell lymphoma 28.2 TNFRSF8 TIA1 NCAM1 MME CD5 CCND1
21 mature t-cell and nk-cell lymphoma 28.2 TNFRSF8 TIA1 NCAM1 MME CD79A CD5
22 gallbladder lymphoma 28.0 TNFRSF8 SPN MME MALT1 CD79A CD5
23 lymphoma, non-hodgkin, familial 27.6 TNFRSF8 SPN SERPINA3 NCAM1 NBN MME
24 type c thymoma 10.3 SERPINA3 CD5
25 endocrine exophthalmos 10.3 MME CD5
26 sarcomatoid squamous cell skin carcinoma 10.3 SERPINA3 MME
27 breast malignant phyllodes tumor 10.3 SERPINA3 MME
28 hilar lung carcinoma 10.3 MME CD79A
29 lung hilum cancer 10.3 MME CD79A
30 liver lymphoma 10.3 MME CD79A
31 testicular malignant germ cell cancer 10.3 TNFRSF8 SERPINA3
32 parapsoriasis 10.3 TNFRSF8 CD5
33 retroperitoneal lymphoma 10.3 TNFRSF8 MME
34 follicular mucinosis 10.3 TNFRSF8 CD5
35 histiocytic and dendritic cell cancer 10.3 TNFRSF8 SERPINA3
36 hodgkin's lymphoma, lymphocytic depletion 10.3 TNFRSF8 CD79A
37 polyclonal hypergammaglobulinemia 10.3 SERPINA3 MME
38 chest wall lymphoma 10.3 MME BCL6
39 heart lymphoma 10.3 MME BCL6
40 eye lymphoma 10.3 CD5 BCL6
41 ovarian lymphoma 10.3 MME BCL6
42 mediastinal malignant lymphoma 10.3 TNFRSF8 CD79A
43 mediastinal gray zone lymphoma 10.3 TNFRSF8 CD79A
44 arteriolosclerosis 10.3 SERPINA3 CD79A
45 central epithelioid sarcoma 10.2 TNFRSF8 MME
46 actinobacillosis 10.2 CD79A CD5
47 sweat gland benign neoplasm 10.2 SERPINA3 MME
48 vulvar proximal-type epithelioid sarcoma 10.2 TNFRSF8 MME
49 perivascular tumor 10.2 SERPINA3 MME
50 pilar sheath acanthoma 10.2 TNFRSF8 MME

Graphical network of the top 20 diseases related to Gastrointestinal Lymphoma:



Diseases related to Gastrointestinal Lymphoma

Symptoms & Phenotypes for Gastrointestinal Lymphoma

MGI Mouse Phenotypes related to Gastrointestinal Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 BCL6 CCND1 CD5 CD79A MALT1 NBN
2 immune system MP:0005387 9.32 BCL6 CCND1 CD5 CD79A MALT1 MME

Drugs & Therapeutics for Gastrointestinal Lymphoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients Recruiting NCT03930043

Search NIH Clinical Center for Gastrointestinal Lymphoma

Genetic Tests for Gastrointestinal Lymphoma

Anatomical Context for Gastrointestinal Lymphoma

MalaCards organs/tissues related to Gastrointestinal Lymphoma:

40
Colon, Bone Marrow, Pancreas, Appendix

Publications for Gastrointestinal Lymphoma

Articles related to Gastrointestinal Lymphoma:

(show top 50) (show all 385)
# Title Authors PMID Year
1
A 10-year cohort study of 175 primary gastrointestinal lymphoma cases in Thailand: clinical features and outcomes in the immunochemotherapy era. 61
33618613 2021
2
Double percutaneous transesophageal gastrotubing precluded high risk surgery for intestinal malignant lymphoma. 61
33747497 2021
3
Prognostic value of small intestinal dilatation in dogs with protein-losing enteropathy. 61
33431757 2021
4
Can cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) be diagnosed in a patient with non-steroidal anti-inflammatory drug exposure? 61
33542016 2021
5
Small Intestinal Adenocarcinoma in a Patient With Celiac Disease. 61
33665060 2021
6
Primary appendiceal Burkitt's lymphoma presenting as acute appendicitis: An extremely rare case report and review of the literatture. 61
33363721 2021
7
A Complicated Case of Diffuse Large B-Cell Lymphoma in an Elderly Presenting with Massive Gastrointestinal Bleeding Successfully Treated with R-mini CHOP. 61
33776714 2021
8
Genomic Mutation Profile of Primary Gastrointestinal Diffuse Large B-Cell Lymphoma. 61
33747936 2021
9
Ileo-Colonic Fistula Due to Diffuse Large B Cell Lymphoma: Unusual Presentation of a Rare Disease. 61
33659111 2021
10
Retrospective assessment of the clinical relevance of surgical biopsies of abdominal lymph nodes in cats: 51 cases (2014-2018). 61
32419573 2020
11
Presumptive precursor-targeted immune-mediated anemia concurrent with gastrointestinal lymphoma in a cat. 61
32863286 2020
12
Secondary gastric lymphoma - Do we know its endoscopic findings? 61
32755150 2020
13
Non-Hodgkin Lymphoma of the jejunum presenting as perforation peritonitis: A case report. 61
32477511 2020
14
An Endoscopic Biopsy Specimen Contains Adequate Lymphocytes for Flow Cytometric Analysis of Light Chain Expression in the Gastrointestinal Mucosa. 61
32581024 2020
15
Genome-wide DNA methylation analysis in canine gastrointestinal lymphoma. 61
32213750 2020
16
Hair nicotine concentration of cats with gastrointestinal lymphoma and unaffected control cases. 61
31974267 2020
17
Mucosa-associated Lymphoid Tissue Lymphoma-mimicking Primary Gastrointestinal Small Lymphocytic Lymphoma. 61
32326688 2020
18
Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma. 61
31493237 2020
19
Technique for single-step lymphocyte isolation from an endoscopic biopsy specimen for the diagnosis of gastrointestinal lymphoma. 61
33102158 2020
20
Successful Endoscopic Resection of Mucosa-Associated Lymphoid Tissue Lymphoma of the Colon. 61
31832456 2019
21
Outcomes in 40 cats with discrete intermediate- or large-cell gastrointestinal lymphoma masses treated with surgical mass resection (2005-2015). 61
31287179 2019
22
Favorable radiation field decrease in gastric marginal zone lymphoma : Experience of the German Study Group on Gastrointestinal Lymphoma (DSGL). 61
30859254 2019
23
Primary Diffuse Large B-cell Lymphoma of the Sigmoid Colon. 61
31501739 2019
24
Gastrointestinal lymphoma: an unusual presentation. 61
31079047 2019
25
Development and internal validation of a risk scoring system for gastrointestinal events requiring surgery in gastrointestinal lymphoma patients. 61
30151937 2019
26
Feline large-cell lymphoma following previous treatment for small-cell gastrointestinal lymphoma: incidence, clinical signs, clinicopathologic data, treatment of a secondary malignancy, response and survival. 61
29877752 2019
27
Evaluation of 22 Primary Gastrointestinal Lymphoma Patients. 61
30911257 2019
28
Gastrointestinal lymphoma: the new mimic. 61
31645987 2019
29
Aneurysmal dilation of bowel mimicking an abscess in pediatric primary gastrointestinal lymphoma. 61
30338011 2019
30
[Malignant gastrointestinal lymphoma with cicatricial stenosis after complete response to chemotherapy]. 61
31597881 2019
31
Spontaneous cholecystopleural fistula leading to biliothorax and sepsis in a cat. 61
30792876 2019
32
Transabdominal ultrasonographic features in the diagnosis of gastrointestinal lymphoma. 61
30603141 2018
33
[Imaging characteristics of gastrointestinal neoplastic acute abdomen]. 61
30506532 2018
34
Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease. 61
30305106 2018
35
Gastric Cancer Screening in Common Variable Immunodeficiency. 61
30219982 2018
36
Primary Gastrointestinal Diffuse Large B-cell Lymphoma. 61
30430047 2018
37
Post-chemotherapy perforation in cats with discrete intermediate- or large-cell gastrointestinal lymphoma. 61
28809125 2018
38
Incidence Rate, Subtype Frequency, and Occurrence Site of Malignant Lymphoma in the Gastrointestinal Tract: Population-Based Analysis in Miyagi, Japan. 61
29998914 2018
39
Burkitt's lymphoma presenting as acute appendicitis: a case report. 61
29942479 2018
40
Expression of programmed cell death 1/programmed cell death ligand 1 in the tumor microenvironments of primary gastrointestinal diffuse large B cell lymphomas. 61
29598887 2018
41
Low-grade gastrointestinal lymphoma in dogs: 20 cases (2010 to 2016). 61
29027206 2018
42
World Health Organisation Classification of Lymphoid Tumours in Veterinary and Human Medicine: a Comparative Evaluation of Gastrointestinal Lymphomas in 61 Cats. 61
29598998 2018
43
The clinical manifestation, survival outcome and predictive prognostic factors of 137 patients with primary gastrointestinal lymphoma (PGIL): Strobe compliant. 61
29505542 2018
44
A retrospective evaluation of lomustine (CeeNU) in 32 treatment naïve cats with intermediate to large cell gastrointestinal lymphoma (2006-2013). 61
27277825 2017
45
[Surgical treatment and prognostic analysis for 57 patients with gastrointestinal lymphoma]. 61
28900997 2017
46
Specific immunotypes of canine T cell lymphoma are associated with different outcomes. 61
28895866 2017
47
Colonic basidiobolomycosis with liver involvement masquerading as gastrointestinal lymphoma: a case report and literature review. 61
29160525 2017
48
The value of EUS in combination with cytological, flow cytometry, and gene rearrangement in the diagnosis of gastrointestinal lymphoma. 61
27139890 2017
49
Extensive colorectal lymphomatous polyposis complicated by acute intestinal obstruction: a case report. 61
28705174 2017
50
EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features. 61
28438623 2017

Variations for Gastrointestinal Lymphoma

Expression for Gastrointestinal Lymphoma

Search GEO for disease gene expression data for Gastrointestinal Lymphoma.

Pathways for Gastrointestinal Lymphoma

Pathways related to Gastrointestinal Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 TNFRSF8 NCAM1 MALT1 CD79A BCL6
2 11.2 SPN NCAM1 MME
3 11.09 SPN NCAM1 MME CD79A CD5
4 10.54 SERPINA3 CCND1

GO Terms for Gastrointestinal Lymphoma

Cellular components related to Gastrointestinal Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.96 NBN BCL6
2 external side of plasma membrane GO:0009897 8.92 SPN NCAM1 CD79A CD5

Sources for Gastrointestinal Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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