MCID: GST048
MIFTS: 22

Gastrointestinal System Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Benign Neoplasm

MalaCards integrated aliases for Gastrointestinal System Benign Neoplasm:

Name: Gastrointestinal System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050624

Summaries for Gastrointestinal System Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm located in gastrointestinal tract organs.

MalaCards based summary : Gastrointestinal System Benign Neoplasm is related to intestinal benign neoplasm and gastric leiomyoma. An important gene associated with Gastrointestinal System Benign Neoplasm is MIR21 (MicroRNA 21), and among its related pathways/superpathways are MicroRNAs in cancer and Parkinsons Disease Pathway. Affiliated tissues include gastrointestinal tract.

Related Diseases for Gastrointestinal System Benign Neoplasm

Diseases related to Gastrointestinal System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 intestinal benign neoplasm 31.8 SERPINA3 MIR532 MIR21 MIR20A MIR199A1 MIR196A1
2 gastric leiomyoma 11.2
3 pleomorphic adenoma 11.2
4 extrahepatic bile duct leiomyoma 11.2
5 anus leiomyoma 11.2
6 gallbladder leiomyoma 11.2
7 appendix leiomyoma 11.2
8 pyelitis 10.5 SERPINA3 INS CCR6
9 persistent generalized lymphadenopathy 10.5 SERPINA3 MIR21 MEN1
10 progressive relapsing multiple sclerosis 10.5 SERPINA3 H2AC18 CCR6
11 sebaceous gland disease 10.5 SERPINA3 INS CCR6
12 pancreatic endocrine carcinoma 10.5 SERPINA3 MEN1 INS
13 microvascular complications of diabetes 3 10.5 MIR21 MIR192 INS
14 coronavirus infectious disease 10.5 SERPINA3 MIR17 H2AC18 CCR6
15 parasitic helminthiasis infectious disease 10.5 SERPINA3 MIR21 H2AC18 CCR6
16 central nervous system hematologic cancer 10.5 MIR199A1 MIR18A CCR6
17 autoimmune disease of cardiovascular system 10.5 SERPINA3 H2AC18 CCR6
18 vein disease 10.5 SERPINA3 INS CCR6
19 connective tissue benign neoplasm 10.5 SERPINA3 H2AC18 CTNNB1
20 feingold syndrome 1 10.5 MIR20A MIR18A MIR17
21 acute cystitis 10.5 SERPINA3 INS H2AC18 CCR6
22 blood protein disease 10.5 MIR17 H2AC18 CCR6
23 esophagus adenocarcinoma 10.5 MIR21 MIR199A1 MIR196A1 MIR143
24 hepatic vascular disease 10.5 MIR199A1 INS CCR6
25 cerebral arterial disease 10.5 SERPINA3 MIR199A1 MIR143
26 pancreatic cystadenoma 10.5 MIR21 MIR196A1 MEN1 INS
27 duodenum cancer 10.5 MIR196A1 MEN1 KRAS
28 mental depression 10.5 SERPINA3 INS H2AC18 CCR6
29 autoimmune disease of skin and connective tissue 10.5 SERPINA3 H2AC18 CCR6
30 duodenum disease 10.5 MIR196A1 MEN1 KRAS
31 aortic valve disease 2 10.5 SERPINA3 MIR21 MIR199A1 MIR17
32 collagen disease 10.5 SERPINA3 H2AC18 CCR6
33 central nervous system benign neoplasm 10.5 SERPINA3 H2AC18 CTNNB1
34 eye degenerative disease 10.5 SERPINA3 MIR17 H2AC18 CCR6
35 ovarian cystadenocarcinoma 10.5 SERPINA3 MIR17 KRAS CTNNB1
36 salivary gland disease 10.5 SERPINA3 PLAG1 H2AC18 CCR6
37 hypersensitivity reaction type iv disease 10.5 SERPINA3 H2AC18 CCR6
38 adrenal gland disease 10.5 MIR139 MEN1 INS CCR6
39 breast carcinoma in situ 10.5 SERPINA3 MIR143 H2AC18 CTNNB1
40 mature t-cell and nk-cell lymphoma 10.5 MIR199A1 MIR17 H2AC18 CCR6
41 microvascular complications of diabetes 5 10.5 MIR21 MIR20A INS H2AC18
42 commensal bacterial infectious disease 10.5 SERPINA3 H2AC18 CCR6
43 respiratory system benign neoplasm 10.5 KRAS H2AC18 CTNNB1
44 autoimmune disease of endocrine system 10.5 MIR142 INS H2AC18 CCR6
45 ureteral disease 10.5 MIR199A1 MIR142 CCR6
46 gastric squamous cell carcinoma 10.5 SERPINA3 CCR6
47 pleural cancer 10.5 MIR17 MIR142 MIR139 H2AC18
48 pleural disease 10.5 MIR199A1 MIR17 H2AC18 CCR6
49 lipomatosis, multiple 10.5 SERPINA3 PLAG1 MEN1
50 chromosomal deletion syndrome 10.5 MIR17 MIR142 H2AC18 CCR6

Graphical network of the top 20 diseases related to Gastrointestinal System Benign Neoplasm:



Diseases related to Gastrointestinal System Benign Neoplasm

Symptoms & Phenotypes for Gastrointestinal System Benign Neoplasm

Drugs & Therapeutics for Gastrointestinal System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Gastrointestinal System Benign Neoplasm

Genetic Tests for Gastrointestinal System Benign Neoplasm

Anatomical Context for Gastrointestinal System Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal System Benign Neoplasm:

19
Gastrointestinal Tract

Publications for Gastrointestinal System Benign Neoplasm

Variations for Gastrointestinal System Benign Neoplasm

Expression for Gastrointestinal System Benign Neoplasm

Search GEO for disease gene expression data for Gastrointestinal System Benign Neoplasm.

Pathways for Gastrointestinal System Benign Neoplasm

Pathways related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 MIR21 MIR20A MIR199A1 MIR192 MIR18A MIR17
2 11.06 MIR20A MIR18A MIR17
3 10.27 MEN1 CTNNB1

GO Terms for Gastrointestinal System Benign Neoplasm

Cellular components related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.44 INS MIR139 MIR142 MIR143 MIR15A MIR17
2 extracellular vesicle GO:1903561 9.35 MIR21 MIR20A MIR192 MIR17 MIR15A

Biological processes related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10 CTNNB1 INS KRAS MIR21 PLAG1
2 negative regulation of gene expression GO:0010629 9.89 PLAG1 MIR21 MIR20A MIR17 CTNNB1
3 positive regulation of protein kinase B signaling GO:0051897 9.86 INS MIR143 MIR199A1 MIR21
4 positive regulation of angiogenesis GO:0045766 9.83 MIR143 MIR199A1 MIR20A MIR21
5 positive regulation of osteoblast differentiation GO:0045669 9.75 CTNNB1 MIR20A MIR21
6 negative regulation of angiogenesis GO:0016525 9.73 MIR21 MIR15A MIR143 CTNNB1
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.72 MIR17 MIR20A MIR21
8 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.69 MIR20A MIR199A1 MIR21
9 miRNA mediated inhibition of translation GO:0035278 9.67 MIR15A MIR17 MIR20A MIR21
10 negative regulation of sprouting angiogenesis GO:1903671 9.65 MIR20A MIR18A MIR17
11 activation of protein kinase B activity GO:0032148 9.63 MIR21 MIR143 INS
12 endothelial tube morphogenesis GO:0061154 9.59 CTNNB1 MIR21
13 positive regulation of metalloendopeptidase activity GO:1904685 9.58 MIR17 MIR21
14 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.58 MIR143 MIR20A MIR21
15 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.57 MIR17 MIR21
16 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.56 MIR15A MIR196A1 MIR199A1 MIR20A
17 negative regulation of interleukin-21 production GO:0032705 9.54 MIR192 MIR21
18 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.5 MIR17 MIR199A1 MIR20A
19 negative regulation of vascular endothelial growth factor production GO:1904046 9.46 MIR15A MIR17 MIR199A1 MIR20A
20 gene silencing by miRNA GO:0035195 9.4 MIR139 MIR142 MIR143 MIR15A MIR17 MIR18A
21 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.13 MIR143 MIR17 MIR20A

Molecular functions related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.5 MIR139 MIR142 MIR143 MIR15A MIR17 MIR20A
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.36 MIR139 MIR142 MIR143 MIR15A MIR17 MIR18A

Sources for Gastrointestinal System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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