MCID: GST048
MIFTS: 33

Gastrointestinal System Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Benign Neoplasm

MalaCards integrated aliases for Gastrointestinal System Benign Neoplasm:

Name: Gastrointestinal System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050624

Summaries for Gastrointestinal System Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm located in gastrointestinal tract organs.

MalaCards based summary : Gastrointestinal System Benign Neoplasm is related to intestinal benign neoplasm and thymic neuroendocrine tumor. An important gene associated with Gastrointestinal System Benign Neoplasm is INS (Insulin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. Affiliated tissues include lung, bone and colon, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Gastrointestinal System Benign Neoplasm

Diseases in the Gastrointestinal System Cancer family:

Gastrointestinal System Benign Neoplasm

Diseases related to Gastrointestinal System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 intestinal benign neoplasm 31.4 CEACAM5 CTNNB1 GAST HRAS KRAS PTGS2
2 thymic neuroendocrine tumor 10.3 HRAS MEN1
3 adult hepatocellular carcinoma 10.3 CTNNB1 TP53
4 adenoma of the pancreas 10.3 CHGA SST
5 pituitary gland disease 10.3 INS MEN1 SST
6 hyperinsulinemic hypoglycemia 10.3 INS MEN1 SST
7 rare adenocarcinoma of the breast 10.3 KRAS TP53
8 pancreatic somatostatinoma 10.3 MEN1 SST
9 diabetes mellitus, ketosis-prone 10.3 INS SLC30A10 SLC30A8
10 duodenal disease 10.3 KRAS MEN1 SST
11 somatostatinoma 10.3 CHGA INS SST
12 carcinoid tumors, intestinal 10.3 CHGA MEN1 SST
13 carcinoid syndrome 10.3 CHGA MEN1 SST
14 maturity-onset diabetes of the young, type 9 10.2 FOXM1 GCG INS
15 protoplasmic astrocytoma 10.2 PTGS2 TP53
16 cellular ependymoma 10.2 CHGA TP53
17 dumping syndrome 10.2 GCG INS SST
18 acromegaly 10.2 INS MEN1 SST
19 granulosa cell tumor of the ovary 10.2 CHGA INS TP53
20 periampullary adenoma 10.2 HRAS KRAS SST
21 autoimmune atrophic gastritis 10.2 CHGA GAST
22 autosomal genetic disease 10.2 INS MEN1 TP53
23 hyperinsulinemic hypoglycemia, familial, 7 10.2 GCG INS
24 acinar cell carcinoma 10.2 CHGA CTNNB1 TP53
25 type 1 diabetes mellitus 15 10.2 GCG HRAS INS
26 prediabetes syndrome 10.2 GCG INS SLC30A8
27 ureteral obstruction 10.2 CTNNB1 PTGS2 TP53
28 pylorospasm 10.2 GAST SST
29 maturity-onset diabetes of the young, type 6 10.2 FOXM1 INS PTPRN
30 pulmonary blastoma 10.2 CHGA KRAS TP53
31 barrett's adenocarcinoma 10.2 KRAS PTGS2 TP53
32 hyperplastic polyposis syndrome 10.2 KRAS TP53
33 merkel cell carcinoma 10.2 CHGA SST TP53
34 duodenal somatostatinoma 10.2 INS SST
35 endocrine organ benign neoplasm 10.2 CHGA INS MEN1 SST
36 male reproductive organ cancer 10.2 CHGA CTNNB1 TP53
37 biliary tract neoplasm 10.2 HRAS KRAS TP53
38 liver angiosarcoma 10.2 HRAS KRAS TP53
39 endometrial adenocarcinoma 10.2 CTNNB1 KRAS TP53
40 intrahepatic cholangiocarcinoma 10.2 CTNNB1 KRAS TP53
41 paronychia 10.2 HRAS KRAS
42 ampulla of vater cancer 10.2 HRAS KRAS TP53
43 gastrointestinal neuroendocrine tumor 10.2 CHGA SST
44 female urethral cancer 10.2 CEACAM5 CHGA
45 intracranial chondrosarcoma 10.2 CEACAM5 TP53
46 duodenal ulcer 10.2 GAST INS SST
47 gastrointestinal neuroendocrine benign tumor 10.2 CHGA GAST SST
48 cecum adenocarcinoma 10.2 CHGA HRAS KRAS
49 gastric neuroendocrine neoplasm 10.2 CHGA GAST SST
50 goblet cell carcinoid 10.2 CHGA CTNNB1 GAST

Graphical network of the top 20 diseases related to Gastrointestinal System Benign Neoplasm:



Diseases related to Gastrointestinal System Benign Neoplasm

Symptoms & Phenotypes for Gastrointestinal System Benign Neoplasm

MGI Mouse Phenotypes related to Gastrointestinal System Benign Neoplasm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 CHGA CTNNB1 FOXM1 GAST HRAS IAPP
2 endocrine/exocrine gland MP:0005379 10.37 CHGA CTNNB1 FOXM1 GAST HRAS INS
3 growth/size/body region MP:0005378 10.32 CHGA CTNNB1 HRAS IAPP INS KRAS
4 digestive/alimentary MP:0005381 10.25 CTNNB1 FOXM1 GAST HRAS INS KRAS
5 mortality/aging MP:0010768 10.18 CHGA CTNNB1 FOXM1 GAST HRAS INS
6 immune system MP:0005387 10.17 CTNNB1 FOXM1 GAST IAPP INS KRAS
7 liver/biliary system MP:0005370 10.06 CTNNB1 FOXM1 INS KRAS MEN1 PTGS2
8 muscle MP:0005369 9.92 CHGA CTNNB1 FOXM1 INS KRAS MEN1
9 neoplasm MP:0002006 9.91 CTNNB1 FOXM1 GAST HRAS KRAS MEN1
10 no phenotypic analysis MP:0003012 9.81 CHGA CTNNB1 HRAS INS KRAS PTGS2
11 normal MP:0002873 9.61 CTNNB1 HRAS INS KRAS NIT1 PTGS2
12 renal/urinary system MP:0005367 9.17 CHGA CTNNB1 HRAS INS KRAS PTGS2

Drugs & Therapeutics for Gastrointestinal System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Gastrointestinal System Benign Neoplasm

Genetic Tests for Gastrointestinal System Benign Neoplasm

Anatomical Context for Gastrointestinal System Benign Neoplasm

MalaCards organs/tissues related to Gastrointestinal System Benign Neoplasm:

41
Lung, Bone, Colon, Ovary, Pancreas, Thyroid, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal System Benign Neoplasm:

19
Gastrointestinal Tract Organs

Publications for Gastrointestinal System Benign Neoplasm

Variations for Gastrointestinal System Benign Neoplasm

Expression for Gastrointestinal System Benign Neoplasm

Search GEO for disease gene expression data for Gastrointestinal System Benign Neoplasm.

Pathways for Gastrointestinal System Benign Neoplasm

Pathways related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 CTNNB1 HRAS INS KRAS PTGS2 TP53
2
Show member pathways
12.78 CTNNB1 HRAS INS KRAS TP53
3 12.72 CTNNB1 HRAS KRAS PTGS2 TP53
4
Show member pathways
12.55 CTNNB1 HRAS KRAS PTGS2 TP53
5 12.33 CTNNB1 GAST PTGS2 TP53
6
Show member pathways
12.33 CTNNB1 HRAS KRAS TP53
7
Show member pathways
12.3 CTNNB1 HRAS KRAS MEN1
8 12.29 CTNNB1 HRAS KRAS TP53
9
Show member pathways
12.26 CTNNB1 HRAS KRAS PTGS2
10 12.14 CTNNB1 HRAS KRAS TP53
11
Show member pathways
12.07 CTNNB1 GCG INS SLC30A8
12 12 CTNNB1 KRAS PTGS2 TP53
13 11.94 FOXM1 HRAS KRAS TP53
14
Show member pathways
11.88 HRAS INS KRAS TP53
15
Show member pathways
11.77 HRAS INS KRAS TP53
16 11.69 CTNNB1 HRAS KRAS TP53
17 11.62 CTNNB1 HRAS KRAS TP53
18 11.61 HRAS KRAS TP53
19 11.55 HRAS KRAS TP53
20 11.54 HRAS KRAS TP53
21 11.31 HRAS KRAS PTGS2
22 11.3 CTNNB1 HRAS KRAS TP53
23 10.81 CTNNB1 HRAS KRAS
24 10.74 CTNNB1 SST
25 10.73 HRAS KRAS
26 10.73 CTNNB1 MEN1
27 10.34 HRAS INS KRAS TP53

GO Terms for Gastrointestinal System Benign Neoplasm

Cellular components related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transport vesicle membrane GO:0030658 8.8 CHGA PTPRN SLC30A8

Biological processes related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.88 GAST GCG IAPP INS SST
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.86 CTNNB1 FOXM1 HRAS MEN1 PLAG1 PLAGL2
3 positive regulation of cell proliferation GO:0008284 9.8 CTNNB1 FOXM1 HRAS INS KRAS PTGS2
4 positive regulation of MAPK cascade GO:0043410 9.67 CTNNB1 HRAS IAPP INS
5 Ras protein signal transduction GO:0007265 9.63 HRAS KRAS TP53
6 negative regulation of cell proliferation GO:0008285 9.63 CTNNB1 HRAS MEN1 PTGS2 SST TP53
7 negative regulation of cell differentiation GO:0045596 9.61 CTNNB1 IAPP KRAS
8 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.54 FOXM1 TP53
9 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.52 INS SLC30A10
10 negative regulation of telomerase activity GO:0051974 9.51 MEN1 TP53
11 positive regulation of brown fat cell differentiation GO:0090336 9.49 INS PTGS2
12 positive regulation of gene expression GO:0010628 9.43 CTNNB1 HRAS INS KRAS PLAG1 TP53
13 response to isolation stress GO:0035900 9.4 HRAS KRAS
14 negative regulation of blood vessel diameter GO:0097756 8.8 CHGA INS PTGS2

Molecular functions related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GAST GCG IAPP INS SST

Sources for Gastrointestinal System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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