MCID: GST048
MIFTS: 31

Gastrointestinal System Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Benign Neoplasm

MalaCards integrated aliases for Gastrointestinal System Benign Neoplasm:

Name: Gastrointestinal System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050624

Summaries for Gastrointestinal System Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm located in gastrointestinal tract organs.

MalaCards based summary : Gastrointestinal System Benign Neoplasm is related to intestinal benign neoplasm and rare adenocarcinoma of the breast. An important gene associated with Gastrointestinal System Benign Neoplasm is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and MAPK signaling pathway. Affiliated tissues include gastrointestinal tract organs, and related phenotypes are Decreased viability in esophageal squamous lineage and homeostasis/metabolism

Related Diseases for Gastrointestinal System Benign Neoplasm

Diseases in the Gastrointestinal System Cancer family:

Gastrointestinal System Benign Neoplasm

Diseases related to Gastrointestinal System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 intestinal benign neoplasm 27.6 AREG CCND1 CDX2 CEACAM5 CTNNB1 HRAS
2 rare adenocarcinoma of the breast 11.0 KRAS TP53
3 adult hepatocellular carcinoma 11.0 CTNNB1 TP53
4 female reproductive endometrioid cancer 10.9 CTNNB1 KRT7 TP53
5 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.9 CTNNB1 KRAS TP53
6 protoplasmic astrocytoma 10.9 PTGS2 TP53
7 ovary neuroendocrine neoplasm 10.9 CDX2 KRT7
8 thymoma, familial 10.9 HRAS KIT
9 hyperplastic polyposis syndrome 10.9 KRAS MUTYH TP53
10 mutyh-associated polyposis 10.9 KRAS MUTYH TP53
11 acinar cell carcinoma 10.9 CTNNB1 KRT7 TP53
12 barrett's adenocarcinoma 10.9 KRAS PTGS2 TP53
13 liver angiosarcoma 10.9 HRAS KRAS TP53
14 skin squamous cell carcinoma 10.8 HRAS KRAS TP53
15 adenosquamous pancreas carcinoma 10.8 HRAS KRAS KRT7
16 ovarian clear cell carcinoma 10.8 KRAS KRT7 TP53
17 suppression of tumorigenicity 12 10.8 CTNNB1 HRAS TP53
18 adenosquamous carcinoma 10.8 KRAS KRT7 TP53
19 ureteral obstruction 10.8 CTNNB1 PTGS2 TP53
20 colloid carcinoma of the pancreas 10.8 HRAS KRAS MUC2
21 vaginal benign neoplasm 10.8 CDX2 KRT7
22 cervical adenoma malignum 10.8 HMGA2 KRT7
23 appendix adenocarcinoma 10.8 CDX2 KRT7
24 bronchiolo-alveolar adenocarcinoma 10.8 CDX2 KRAS KRT7
25 malignant ectomesenchymoma 10.8 HMGA2 HRAS
26 vaginal adenoma 10.8 CDX2 KRT7
27 endocervical adenocarcinoma 10.8 CDX2 KRT7 TP53
28 mucinous intrahepatic cholangiocarcinoma 10.8 CDX2 MUC2
29 esophageal disease 10.8 CDX2 PTGS2 TP53
30 adenomyoma 10.8 CTNNB1 KRT7 MLH1
31 pancreatic ductal carcinoma 10.8 KRT7 MUC2 TP53
32 vaginal tubulovillous adenoma 10.8 CDX2 KRT7
33 keratocystic odontogenic tumor 10.7 CCND1 PTGS2 TP53
34 salivary gland adenoma, pleomorphic 10.7 HMGA2 PLAG1
35 polyposis syndrome, hereditary mixed, 1 10.7 MLH1 MUTYH PTGS2
36 embryonal sarcoma 10.7 CTNNB1 KIT TP53
37 adenocarcinoma in situ 10.7 CDX2 KRAS KRT7
38 anus cancer 10.7 CDX2 KRAS KRT7
39 mucoepidermoid esophageal carcinoma 10.7 CEACAM5 TP53
40 penile cancer 10.7 CCND1 HRAS TP53
41 ovarian mucinous adenocarcinoma 10.7 CDX2 KRT7 MUC2
42 pleomorphic carcinoma 10.7 KIT KRT7 TP53
43 lung adenoid cystic carcinoma 10.7 HRAS KIT KRAS
44 necrotizing sialometaplasia 10.7 KIT KRT7 TP53
45 jejunal cancer 10.7 KIT KRT7 MUTYH
46 ampulla of vater adenocarcinoma 10.7 CDX2 KRT7 MUC2
47 ductal carcinoma in situ 10.7 CCND1 PTGS2 TP53
48 lung benign neoplasm 10.7 HRAS KRAS KRT7 TP53
49 core binding factor acute myeloid leukemia 10.7 HRAS KIT KRAS
50 epithelial-myoepithelial carcinoma 10.7 HMGA2 HRAS KRT7 TP53

Graphical network of the top 20 diseases related to Gastrointestinal System Benign Neoplasm:



Diseases related to Gastrointestinal System Benign Neoplasm

Symptoms & Phenotypes for Gastrointestinal System Benign Neoplasm

GenomeRNAi Phenotypes related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.32 CTNNB1 HRAS KIT KRAS KRT7 MFSD1

MGI Mouse Phenotypes related to Gastrointestinal System Benign Neoplasm:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.38 MUTYH TP53 PLAGL2 MTHFR PTGS2 MUC2
2 digestive/alimentary MP:0005381 10.34 PLAGL2 PTGS2 MUC2 TP53 CTNNB1 CCND1
3 growth/size/body region MP:0005378 10.34 TP53 PLAG1 PLAGL2 MTHFR PTGS2 MUC2
4 cellular MP:0005384 10.33 MUTYH MLH1 PTGS2 MUC2 CDX2 CTNNB1
5 endocrine/exocrine gland MP:0005379 10.32 TP53 PLAG1 PTGS2 MUC2 AREG CTNNB1
6 mortality/aging MP:0010768 10.31 MUTYH TP53 MLH1 PLAGL2 MTHFR PTGS2
7 cardiovascular system MP:0005385 10.26 PTGS2 MUC2 CDX2 AREG CTNNB1 CCND1
8 integument MP:0010771 10.2 TP53 MLH1 MTHFR PTGS2 AREG CTNNB1
9 neoplasm MP:0002006 10.18 PTGS2 MUC2 TP53 MUTYH CTNNB1 CCND1
10 craniofacial MP:0005382 10.08 CTNNB1 CCND1 HRAS KRAS KIT LGR5
11 reproductive system MP:0005389 10 PLAG1 MLH1 MTHFR PTGS2 CDX2 AREG
12 renal/urinary system MP:0005367 9.92 PTGS2 CTNNB1 HRAS KRAS KRT7 KIT
13 no phenotypic analysis MP:0003012 9.91 MTHFR PTGS2 CTNNB1 HRAS KRAS KIT
14 respiratory system MP:0005388 9.81 MLH1 PTGS2 CTNNB1 CCND1 KRAS KIT
15 skeleton MP:0005390 9.61 MTHFR PTGS2 CDX2 CTNNB1 CCND1 HRAS
16 vision/eye MP:0005391 9.32 PLAG1 MLH1 MTHFR PTGS2 AREG CTNNB1

Drugs & Therapeutics for Gastrointestinal System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Gastrointestinal System Benign Neoplasm

Genetic Tests for Gastrointestinal System Benign Neoplasm

Anatomical Context for Gastrointestinal System Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal System Benign Neoplasm:

19
Gastrointestinal Tract Organs

Publications for Gastrointestinal System Benign Neoplasm

Variations for Gastrointestinal System Benign Neoplasm

Expression for Gastrointestinal System Benign Neoplasm

Search GEO for disease gene expression data for Gastrointestinal System Benign Neoplasm.

Pathways for Gastrointestinal System Benign Neoplasm

Pathways related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 AREG CCND1 CTNNB1 HRAS KIT KRAS
2 12.7 AREG HRAS KIT KRAS TP53
3
Show member pathways
12.64 CTNNB1 HRAS KRAS PTGS2 TP53
4
Show member pathways
12.6 AREG CCND1 CTNNB1 HRAS KIT KRAS
5
Show member pathways
12.49 CCND1 CTNNB1 HRAS KRAS PTGS2 TP53
6 12.48 CCND1 CTNNB1 HRAS KIT KRAS MLH1
7
Show member pathways
12.44 AREG CCND1 CTNNB1 HRAS KRAS TP53
8
Show member pathways
12.42 AREG CCND1 HRAS KRAS TP53
9 12.41 CCND1 HMGA2 HRAS KRAS PTGS2 TP53
10
Show member pathways
12.38 CTNNB1 HRAS KRAS TP53
11
Show member pathways
12.36 CCND1 CTNNB1 HRAS KRAS
12 12.36 CCND1 CTNNB1 HRAS KRAS TP53
13
Show member pathways
12.33 CTNNB1 HRAS KRAS PTGS2
14 12.24 CCND1 CTNNB1 HRAS KRAS TP53
15 12.22 CCND1 HRAS KRAS TP53
16 12.1 CCND1 HRAS KRAS TP53
17 12.08 CCND1 HRAS KRAS TP53
18 12.07 CCND1 CTNNB1 KRAS TP53
19
Show member pathways
11.94 CCND1 CDX2 CTNNB1 HRAS KIT KRAS
20 11.9 CCND1 CTNNB1 HRAS KRAS TP53
21 11.86 CCND1 CTNNB1 HRAS KRAS TP53
22 11.81 CCND1 CTNNB1 HRAS KRAS TP53
23
Show member pathways
11.74 HRAS KIT KRAS
24 11.71 CCND1 KIT PTGS2
25 11.69 CCND1 HRAS KRAS TP53
26 11.65 CCND1 CTNNB1 KRAS MLH1 PTGS2 TP53
27 11.62 HRAS KIT KRAS TP53
28 11.61 HRAS KRAS TP53
29 11.49 CCND1 PTGS2 TP53
30 11.46 HRAS KRAS PTGS2
31 11.22 CTNNB1 HRAS KRAS
32 11.09 CCND1 HRAS KRAS
33 10.77 HRAS KRAS

GO Terms for Gastrointestinal System Benign Neoplasm

Biological processes related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.88 CDX2 CTNNB1 HMGA2 PLAG1 PLAGL2 TP53
2 regulation of cell proliferation GO:0042127 9.83 CTNNB1 KIT LGR5 PTGS2
3 cytokine-mediated signaling pathway GO:0019221 9.77 CCND1 KIT KRAS PTGS2 TP53
4 Ras protein signal transduction GO:0007265 9.69 HRAS KRAS TP53
5 positive regulation of MAP kinase activity GO:0043406 9.65 HRAS KIT KRAS
6 epidermal growth factor receptor signaling pathway GO:0007173 9.63 AREG HRAS KRAS
7 response to estradiol GO:0032355 9.56 AREG CCND1 CTNNB1 PTGS2
8 base-excision repair GO:0006284 9.5 HMGA2 MUTYH TP53
9 positive regulation of gene expression GO:0010628 9.5 CTNNB1 HMGA2 HRAS KIT KRAS PLAG1
10 mitotic G1 DNA damage checkpoint GO:0031571 9.49 CCND1 TP53
11 response to glucocorticoid GO:0051384 9.46 AREG CCND1 KRAS PTGS2
12 response to isolation stress GO:0035900 9.43 HRAS KRAS
13 positive regulation of cell proliferation GO:0008284 9.23 AREG CCND1 CDX2 CTNNB1 HRAS KIT

Molecular functions related to Gastrointestinal System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.35 CCND1 CTNNB1 HMGA2 PTGS2 TP53
2 MutSalpha complex binding GO:0032407 8.62 MLH1 MUTYH

Sources for Gastrointestinal System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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