MCID: GST050
MIFTS: 64

Gastrointestinal System Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Disease

MalaCards integrated aliases for Gastrointestinal System Disease:

Name: Gastrointestinal System Disease 12 15
Gastrointestinal Diseases 55 73
Digestive System Disorders 73
Alimentary System Disease 12
Digestive System Disorder 12
Gastrointestinal Disorder 12
Digestive System Diseases 44
Gastrointestinal Disease 12
Gastroenteropathy 12
Git Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:77
ICD9CM 35 520-579.99
MeSH 44 D004066

Summaries for Gastrointestinal System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the gastrointestinal tract.

MalaCards based summary : Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to celiac disease 1 and esophageal disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Gastrointestinal System Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and IL-17 Family Signaling Pathways. The drugs Lansoprazole and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, liver and colon, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 76 Gastrointestinal diseases refer to diseases involving the gastrointestinal tract, namely the esophagus,... more...

Related Diseases for Gastrointestinal System Disease

Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 celiac disease 1 33.0 ALB CCK GHRL PYY TNF
2 esophageal disease 32.9 ATP12A ATP4A GAST TRPV1
3 mouth disease 32.9 IL1B TLR9 TNF TRPV1
4 gallbladder disease 32.8 CCK CCKAR MLN
5 diarrhea 32.8 ALB CCK GAST TNF
6 peritonitis 32.7 ALB IL1B TNF
7 polyposis, skin pigmentation, alopecia, and fingernail changes 32.7 ALB ATP12A ATP4A
8 intestinal disease 32.0 ALB AREG GCG GHRL HTR4 IL1B
9 stomach disease 31.8 AREG ATP12A ATP4A CCK GAST GHRL
10 gastroenteritis 31.7 ALB CCL11 IL1B TNF
11 appendicitis 31.6 ALB IL1B TNF
12 duodenitis 31.5 ATP12A ATP4A GAST
13 dyspepsia 31.4 CCK CCKAR GHRL TRPV1
14 irritable bowel syndrome 31.4 CCK HTR4 MLN TLR9 TNF TRPV1
15 gastritis 31.4 AREG GAST GHRL IL1B S100A8
16 eating disorder 31.3 CCK GHRL PYY
17 constipation 31.2 CCK GAST HTR4 MLN PYY
18 helicobacter pylori infection 31.2 GAST IL1B S100A8 TNF
19 gastroesophageal reflux 30.6 CCK GAST GCG GHRL IL1B MLN
20 bile reflux 11.3 ATP12A ATP4A CCK
21 gastrointestinal neuroendocrine benign tumor 11.3 ATP12A ATP4A GAST
22 gastric neuroendocrine neoplasm 11.3 ATP12A ATP4A GAST
23 eosinophilic gastritis 11.3 ATP12A ATP4A CCL11
24 granulomatous gastritis 11.3 ATP12A ATP4A GAST
25 capillary disease 11.3 ALB ATP12A ATP4A
26 lymphocytic colitis 11.3 ATP12A ATP4A PYY
27 peptic esophagitis 11.3 ATP12A ATP4A IL1B
28 esophagitis, eosinophilic, 1 11.3 ATP12A ATP4A CCL11
29 fungal esophagitis 11.3 ATP12A ATP4A
30 clostridium difficile colitis 11.3 ATP12A ATP4A IL1B
31 duodenal disease 11.3 ATP12A ATP4A CCK SCT
32 eosinophilic enteropathy 11.3
33 nasal cavity disease 11.3 CCL11 TLR9 TRPV1
34 pneumatosis cystoides intestinalis 11.3 ATP12A ATP4A PYY
35 esophageal varix 11.3 ALB ATP12A ATP4A
36 gastric lymphoma 11.3 ALB ATP12A ATP4A
37 postcholecystectomy syndrome 11.3 CCK GAST MLN
38 aspiration pneumonia 11.3 ALB ATP12A ATP4A TRPV1
39 nose disease 11.3 CCL11 TLR9 TNF TRPV1
40 exocrine pancreatic insufficiency 11.2 CCK CCKAR SCT
41 central nervous system vasculitis 11.2 IL1B TLR9 TNF
42 upper respiratory tract disease 11.2 CCL11 TLR9 TNF TRPV1
43 duodenal gastrinoma 11.2 CCK GAST SCT
44 dental pulp disease 11.2 IL1B TNF TRPV1
45 paine syndrome 11.2 ATP12A ATP4A IL1B TRPV1
46 burns 11.2 ALB IL1B TNF
47 pulpitis 11.2 IL1B TNF TRPV1
48 bladder calculus 11.2 ATP12A ATP4A
49 middle ear disease 11.2 IL1B TLR9 TNF
50 parasitic helminthiasis infectious disease 11.2 TLR9 TNF TRPV1

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to Gastrointestinal System Disease

Symptoms & Phenotypes for Gastrointestinal System Disease

UMLS symptoms related to Gastrointestinal System Disease:


abdominal pain, constipation, diarrhea, dyspepsia, halitosis, heartburn, icterus, nausea and vomiting, oral manifestations, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, digestive system symptom, gastrointestinal gas, abdomen, acute, abdominal cramps, eructation, flatulence, flatulence, eructation, and gas pain, glossalgia, nausea, rectal pain, signs and symptoms, digestive, vomiting, liver tender, symptoms involving digestive system, other symptoms involving digestive system, odynophagia, decrease in appetite, abdominal discomfort, upper abdominal pain, lower abdominal pain, retching, rectal tenesmus, dry throat, hyperemesis, abdominal distress, epigastric pain not food-related, right upper quadrant pain, epigastric food-related pain, upset stomach, abdominal fullness, salivary gland pain, abdominal distention, gaseous, anal pain, infantile colic, vomiting in newborn, change in bowel habits, stomach cramps (finding), gastric irritation, swallowing problems, gastrointestinal symptoms, sore lip, gastrointestinal pain, vomiting alone, abdominal distress/pain as reason for lower g.i. examination, abdominal distress/pain as reason for upper g.i. examination, anal discomfort, abdominal bloating, epigastric discomfort, blood in stool, catarrh, peeling tongue

MGI Mouse Phenotypes related to Gastrointestinal System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.61 GHRL TLR9 TNF ALB AREG ATP12A
2 homeostasis/metabolism MP:0005376 9.47 GHRL HTR4 IL1B PYY TLR9 TNF

Drugs & Therapeutics for Gastrointestinal System Disease

Drugs for Gastrointestinal System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1389)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103577-45-3 3883
2
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154361-50-9 60953
3
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-66-6 23994
4
Sucralfate Approved Phase 4,Not Applicable,Early Phase 1 54182-58-0 0
5
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
6
Spironolactone Approved Phase 4,Phase 2,Phase 3 1952-01-7, 52-01-7 5833
7
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
8
Etomidate Approved Phase 4,Phase 2 33125-97-2 36339 667484
9
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
10
Ceftriaxone Approved Phase 4,Phase 3,Phase 2,Not Applicable 73384-59-5 5479530 5361919
11
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
12
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 111025-46-8 4829
13
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
14
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
15
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
16
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7782-49-2
17
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
18
Nicotine Approved Phase 4,Phase 3,Not Applicable 54-11-5 942 89594
19
Remifentanil Approved Phase 4,Phase 2,Not Applicable 132875-61-7 60815
20
Amlodipine Approved Phase 4,Phase 1,Phase 2 88150-42-9 2162
21
Simvastatin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 79902-63-9 54454
22
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
23
Famotidine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 76824-35-6 3325
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 50-23-7 5754
25
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
26
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 36791-04-5 37542
27
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 28523-86-6 5206
28
Alvimopan Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 156053-89-3 5488548
29
Meropenem Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 119478-56-7 64778 441130
30
Methylene blue Approved, Investigational Phase 4,Phase 3,Not Applicable 61-73-4
31
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
32
Warfarin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81-81-2 6691 54678486
33
Losartan Approved Phase 4,Phase 3,Phase 2 114798-26-4 3961
34
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128-13-2 31401
35
Terlipressin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 14636-12-5 72081
36
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 114-07-8 12560
37
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Not Applicable 163222-33-1 150311
38
Mianserin Approved, Investigational Phase 4 24219-97-4 4184
39
Midodrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 133163-28-7, 42794-76-3 4195
40
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 9005-49-6 772 46507594
41
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1 4205-90-7 2803
42
Lamivudine Approved, Investigational Phase 4,Phase 1,Phase 2 134678-17-4 60825
43
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 97682-44-5, 100286-90-6 60838
44
Glycerol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56-81-5 753
45
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
46
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
47
Rifampicin Approved Phase 4,Phase 1,Not Applicable 13292-46-1 5458213 5381226
48
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
49
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 69-65-8 453 6251
50
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
2 Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study Unknown status NCT01737463 Phase 4
3 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4 N-acetylcysteine
4 Prospective Random Comparing Study on EUS-guided Pseudocyst Drainage by Naso-pancreatic Tube and Stents Unknown status NCT01585662 Phase 4
5 Mast Cells in Acid-induced Intestinal Permeability Unknown status NCT02664051 Phase 4 Nalcrom;placebo
6 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
7 Diverticulitis: Antibiotics or Close Observation? Unknown status NCT01111253 Phase 4 Amoxicillin-clavulanate
8 Double- Versus Single-balloon Enteroscopy for Obscure Small-bowel Bleeding Unknown status NCT01176864 Phase 4
9 Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease Unknown status NCT02213224 Phase 4 Perindopril;Telmisartan;Amlodipine
10 The Effect Of Dual Treatment With L-Carnitine And Magnesium On Fatty Liver Unknown status NCT01956825 Phase 4
11 The Orange-III Trial: Optimised Recovery With Movicol® Preoperatively Within an Enhanced Recovery Programme Unknown status NCT01429779 Phase 4 Movicol
12 Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease Unknown status NCT00941642 Phase 4 Lovaza;placebo control
13 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
14 A Study of Thymoglobulin and Tacrolimus in Liver Transplant Unknown status NCT00564538 Phase 4 anti-thymocyte globulin (rabbit);tacrolimus
15 Intravenous-Morphine and Glucagon-Usage Enhanced MR Cholangiography Unknown status NCT00155376 Phase 4 morphine and glucagon
16 Analgesic Efficacy of Intravenous Hyoscine-N-Butylbromide (HNB) in Abdominal Colic Associated With Acute Gastroenteritis Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
17 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
18 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
19 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
20 Complex Imaging Assessment of Steatosis Unknown status NCT02669641 Phase 4
21 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
22 Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
23 TO Compare the Triple Drug Therapy and Dual Therapy . Unknown status NCT02075242 Phase 4 Mycophenolate Mofetil;Tacrolimus
24 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
25 Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01950884 Phase 4 Ezetimibe
26 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
27 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
28 A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol Unknown status NCT01298284 Phase 4 propranolol
29 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4 Esomeprazole;esomeprazole
30 Single-Operator Versus Dual-Operator Double-balloon Endoscopy in Patients With Small-Bowel Disorders Unknown status NCT01184690 Phase 4
31 Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding Unknown status NCT00567216 Phase 4 Nadolol
32 Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding Unknown status NCT00861640 Phase 4 Intravenous Omeprazole;Oral Rabeprazole
33 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
34 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
35 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
36 Rifaximin Predicts the Complications of Decompensated Cirrhosis Unknown status NCT02074280 Phase 4 rifaximin
37 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
38 Magnesium in Liver Cirrhosis Unknown status NCT01894867 Phase 4
39 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
40 Development of an Imaging Biomarker for Hepatic Fibrosis Using Gadoxetate Disodium Unknown status NCT01783314 Phase 4
41 Telbivudine Renoprotective Effect in Patients With HBV-related Liver Cirrhosis Unknown status NCT01693679 Phase 4 Telbivudine, Lamivudine, Adefovir ,Enecavir
42 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
43 RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
44 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Unknown status NCT02056405 Phase 4 Mosapride;Placebo
45 Effect of Betablocker or Aldosterone Antagonist Therapy on Patients With Liver Cirrhosis Unknown status NCT00332904 Phase 4 propranolol;spironolactone
46 Oral Hygiene Regimen in Patients on HCT Unknown status NCT02662374 Phase 4 .02% Chlorohexidine Gluconate;3% Sodium Bicarbonate;Nystatin 10000U/ml;Supersaturated Calcium Phosphate
47 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
48 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
49 Effectiveness of Low Energy Laser Treatment in Oral Mucositis Induced by Chemotherapy and Radiotherapy in Head and Neck Cancer Unknown status NCT01876407 Phase 4
50 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo

Search NIH Clinical Center for Gastrointestinal System Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: digestive system diseases

Genetic Tests for Gastrointestinal System Disease

Anatomical Context for Gastrointestinal System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal System Disease:

19
The Gastrointestinal Tract

MalaCards organs/tissues related to Gastrointestinal System Disease:

41
Liver, Colon, Testes, Bone, T Cells, Lymph Node, Pancreas

Publications for Gastrointestinal System Disease

Articles related to Gastrointestinal System Disease:

(show top 50) (show all 100)
# Title Authors Year
1
Eosinophilic Gastrointestinal Diseases (EGIDs) beyond Eosinophilic Esophagitis (EoE). ( 29940308 )
2018
2
Frequency, Diagnosis, Treatment, and Outcome of Gastrointestinal Disease in Granulomatosis with Polyangiitis and Microscopic Polyangiitis. ( 29419474 )
2018
3
Helicobacter pylori virulence factors in relation to gastrointestinal diseases in Iran. ( 28232251 )
2017
4
Gastrointestinal diseases and their oro-dental manifestations: Part 4: Peutz-Jeghers syndrome. ( 28184053 )
2017
5
Gastrointestinal diseases and their oro-dental manifestations: Part 2: Ulcerative colitis. ( 28084352 )
2017
6
Gastrointestinal Diseases in Pregnancy: Nausea, Vomiting, Hyperemesis Gravidarum, Gastroesophageal Reflux Disease, Constipation, and Diarrhea. ( 27261898 )
2016
7
Food IgG4 antibodies are elevated not only in children with wheat allergy but also in children with gastrointestinal diseases. ( 27004959 )
2016
8
Elevated levels of faecal calprotectin in primary SjAPgren's syndrome is common and associated with concomitant organic gastrointestinal disease. ( 26759247 )
2016
9
Familial Adenomatous Polyposis Manifesting as Lactococcus Endocarditis: A Case Report and Review of the Association of Lactococcus with Underlying Gastrointestinal Disease. ( 27818810 )
2016
10
Comparative genomic analysis of toxin-negative strains of Clostridium difficile from humans and animals with symptoms of gastrointestinal disease. ( 26971047 )
2016
11
Elevated DMBT1 levels in neonatal gastrointestinal diseases. ( 26542257 )
2016
12
A meta-analysis: The association between interleukin-17 pathway gene polymorphism and gastrointestinal diseases. ( 26164762 )
2015
13
Protective role of hemeoxygenase-1 in gastrointestinal diseases. ( 25428780 )
2015
14
The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease. ( 26087059 )
2015
15
[The development of functional gastrointestinal diseases: Genetic aspects]. ( 28635880 )
2015
16
Prevalence of Lactose Malabsorption and Lactose Intolerance in Pediatric Patients with Selected Gastrointestinal Diseases. ( 26768639 )
2015
17
From past sailors' eras to the present day: scurvy as a surprising manifestation of an uncommon gastrointestinal disease. ( 26376699 )
2015
18
Differential expression and processing of matrix metalloproteinase 19 marks progression of gastrointestinal diseases. ( 25056434 )
2014
19
The role of endoscopy and biopsy in the management of severe gastrointestinal disease in cystic fibrosis patients. ( 23825099 )
2013
20
Progressive multifocal leukoencephalopathy with gastrointestinal disease in a pediatric kidney transplant recipient. ( 23902604 )
2013
21
A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection. ( 23637547 )
2013
22
Impact of cytomegalovirus gastrointestinal disease on the clinical outcomes in patients with gastrointestinal graft-versus-host disease in the era of preemptive therapy. ( 23180439 )
2013
23
Multiple-dose therapy with bovine colostrum confers significant protection against diarrhea in a mouse model of human rotavirus-induced gastrointestinal disease. ( 23200479 )
2013
24
The role of IL-15 in gastrointestinal diseases: a bridge between innate and adaptive immune response. ( 23791986 )
2013
25
The role of peptide YY in gastrointestinal diseases and disorders (review). ( 23292145 )
2013
26
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome. ( 23061432 )
2012
27
Laparoscopic bladder-preserving surgery for enterovesical fistula complicated with benign gastrointestinal disease. ( 22754487 )
2012
28
Ghrelin in gastrointestinal disease. ( 21458525 )
2011
29
Changing prevalence of some selected gastrointestinal diseases vis-A -vis H. pylori infection. ( 21830443 )
2011
30
Helicobacter pylori infection and gastritis: the Systematic Investigation of gastrointestinaL diseases in China (SILC). ( 21198827 )
2011
31
The management of gastrointestinal disease in Hermansky-Pudlak syndrome. ( 21085008 )
2011
32
NOD2/CARD15 genotype and common gastrointestinal diseases in 43,600 individuals. ( 19570052 )
2010
33
Epidemiology of peptic ulcer disease: endoscopic results of the systematic investigation of gastrointestinal disease in China. ( 20736940 )
2010
34
Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. ( 20399894 )
2010
35
Teduglutide, a glucagon-like peptide-2 analog for the treatment of gastrointestinal diseases, including short bowel syndrome. ( 21154171 )
2010
36
Cystic fibrosis gene mutations and gastrointestinal diseases. ( 20442009 )
2010
37
Campylobacteriosis and other bacterial gastrointestinal diseases in Sofia, Bulgaria for the period 1987-2008. ( 20122383 )
2010
38
[Relationship between gene polymorphisms in MMP-9 and Helicobacter pylori-related upper gastrointestinal disease in children]. ( 20416216 )
2010
39
Decreased Serum Hepatocyte Growth Factor (HGF) in Autistic Children with Severe Gastrointestinal Disease. ( 20029653 )
2009
40
Collagenous gastritis: histopathologic features and association with other gastrointestinal diseases. ( 19295410 )
2009
41
Chemotactic factors associated with eosinophilic gastrointestinal diseases. ( 19141349 )
2009
42
Prevalence of clonorchiasis in patients with gastrointestinal disease: a Korean nationwide multicenter survey. ( 19115472 )
2009
43
[Significance of serum autotaxin activity in gastrointestinal disease]. ( 19522250 )
2009
44
Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review). ( 19885611 )
2009
45
Intestinal alkaline phosphatase: the molecular link between rosacea and gastrointestinal disease? ( 19573995 )
2009
46
Biomarkers for nononcologic gastrointestinal diseases. ( 19141347 )
2009
47
Lactoferrin in gastrointestinal disease. ( 19652425 )
2009
48
The role of the high-affinity IgE receptor, FcepsilonRI, in eosinophilic gastrointestinal diseases. ( 19141351 )
2009
49
Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention. ( 18710364 )
2008
50
Patterns of gastrointestinal disease associated with mutations of CFTR. ( 18625144 )
2008

Variations for Gastrointestinal System Disease

Expression for Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for Gastrointestinal System Disease

Pathways related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CCK CCKAR GCG GHRL HTR4 MLN
2
Show member pathways
12.09 CCL11 IL1B S100A8 TNF
3
Show member pathways
11.92 CCL11 IL1B TLR9 TNF
4 11.52 IL1B TLR9 TNF
5 11.41 CCL11 IL1B TNF
6 11.23 IL1B TLR9 TNF
7 10.88 IL1B TLR9 TNF
8 10.64 AREG IL1B TNF
9 10.02 ATP4A GAST
10 9.64 CCK GAST SCT

GO Terms for Gastrointestinal System Disease

Cellular components related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALB CCK CCL11 GAST GCG GHRL
2 extracellular space GO:0005615 9.47 ALB AREG ATP4A CCK CCL11 GAST

Biological processes related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.79 CCK S100A8 TNF
2 positive regulation of JNK cascade GO:0046330 9.77 IL1B TLR9 TNF
3 regulation of insulin secretion GO:0050796 9.76 GCG IL1B TNF
4 neutrophil chemotaxis GO:0030593 9.75 CCL11 IL1B S100A8
5 positive regulation of interleukin-6 production GO:0032755 9.7 IL1B TLR9 TNF
6 G-protein coupled receptor signaling pathway GO:0007186 9.7 AREG CCK CCKAR CCL11 GAST GCG
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.69 IL1B TLR9 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 IL1B S100A8 TLR9 TNF
9 cellular potassium ion homeostasis GO:0030007 9.63 ATP12A ATP4A
10 sodium ion export across plasma membrane GO:0036376 9.63 ATP12A ATP4A
11 feeding behavior GO:0007631 9.63 CCKAR GCG PYY
12 inflammatory response GO:0006954 9.63 CCL11 IL1B S100A8 TLR9 TNF TRPV1
13 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.62 ATP12A ATP4A
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
15 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.61 IL1B TLR9
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 IL1B TNF TRPV1
17 regulation of appetite GO:0032098 9.6 HTR4 PYY
18 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B TNF
19 chronic inflammatory response GO:0002544 9.56 CCL11 S100A8
20 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF
21 positive regulation of fever generation GO:0031622 9.49 IL1B TNF
22 fever generation GO:0001660 9.48 IL1B TRPV1
23 positive regulation of interleukin-8 production GO:0032757 9.43 IL1B TLR9 TNF
24 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
25 regulation of signaling receptor activity GO:0010469 9.36 AREG CCK CCL11 GAST GCG GHRL
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IL1B TNF
27 signal transduction GO:0007165 10.2 CCK CCKAR CCL11 GAST GCG HTR4

Molecular functions related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 AREG CCL11 IL1B TNF
2 G-protein coupled receptor binding GO:0001664 9.33 GHRL PYY SCT
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP12A ATP4A
4 hormone activity GO:0005179 9.17 CCK GAST GCG GHRL MLN PYY
5 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Gastrointestinal System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
56