MCID: GST050
MIFTS: 63

Gastrointestinal System Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Disease

MalaCards integrated aliases for Gastrointestinal System Disease:

Name: Gastrointestinal System Disease 12 15
Gastrointestinal Diseases 55 73
Gastrointestinal Disease 12 15
Digestive System Disorders 73
Alimentary System Disease 12
Digestive System Disorder 12
Gastrointestinal Disorder 12
Digestive System Diseases 44
Gastroenteropathy 12
Git Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:77
ICD9CM 35 520-579.99
MeSH 44 D004066
SNOMED-CT 68 53619000

Summaries for Gastrointestinal System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the gastrointestinal tract.

MalaCards based summary : Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to diarrhea and esophageal disease, and has symptoms including nausea and vomiting, constipation and vomiting. An important gene associated with Gastrointestinal System Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Microglia Activation During Neuroinflammation: Microglia Polarization. The drugs Trimebutine and Rabeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and colon, and related phenotypes are Reduced mammosphere formation and digestive/alimentary

Wikipedia : 76 Gastrointestinal diseases refer to diseases involving the gastrointestinal tract, namely the esophagus,... more...

Related Diseases for Gastrointestinal System Disease

Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 513)
# Related Disease Score Top Affiliating Genes
1 diarrhea 31.9 ALB CCK GAST TRPV1
2 esophageal disease 31.9 ALB ATP12A ATP4A GAST TRPV1
3 gallbladder disease 31.9 CCK CCKAR MLN
4 intestinal disease 31.9 ALB AREG GCG GHRL TLR9 TNF
5 mouth disease 31.8 TLR9 TNF TRPV1
6 stomach disease 31.8 AREG ATP12A ATP4A GAST GHRL MLN
7 polyposis, skin pigmentation, alopecia, and fingernail changes 31.7 ALB ATP12A ATP4A
8 gastroenteritis 30.7 ALB CCL11 MLN TNF
9 gastritis 30.6 AREG GAST GHRL S100A8
10 pancreas disease 30.5 ALB AREG CCK GAST GCG SCT
11 inflammatory bowel disease 30.4 ALB AREG CCL11 MADCAM1 S100A8 TLR9
12 acute pancreatitis 30.4 CCK CCKAR SCT
13 duodenitis 30.4 ATP12A ATP4A GAST
14 irritable bowel syndrome 30.4 CCK HTR4 MLN PYY TLR9 TNF
15 gastroesophageal reflux 30.4 CCK GAST GCG GHRL MLN PYY
16 constipation 30.3 CCK GAST HTR4 MLN PYY
17 peptic ulcer disease 30.3 ATP4A GAST GHRL S100A8 SCT TNF
18 cholelithiasis 30.3 ALB CCK CCKAR
19 granulomatous gastritis 30.3 ATP12A ATP4A GAST
20 eating disorder 30.3 CCK GHRL PYY
21 pylorospasm 30.3 GAST GHRL HTR4 MLN
22 atrophic gastritis 30.3 GAST GHRL S100A8 TNF
23 esophagitis, eosinophilic, 1 30.3 ATP12A ATP4A CCL11
24 gastroparesis 30.2 CCK GAST GHRL MLN
25 duodenal ulcer 30.1 CCK GAST S100A8 SCT TNF
26 short bowel syndrome 30.1 CCK GCG PYY
27 celiac disease 1 30.1 ALB ATP12A ATP4A CCK GHRL PYY
28 lymphocytic colitis 30.0 ATP12A ATP4A PYY
29 duodenogastric reflux 30.0 CCK GAST MLN PYY SCT
30 dermatitis, atopic 29.9 CCL11 TLR9 TNF TRPV1
31 body mass index quantitative trait locus 11 29.9 CCK CCKAR GCG GHRL PYY TNF
32 dyspepsia 29.9 CCK CCKAR GHRL TRPV1
33 pulmonary disease, chronic obstructive 29.9 AREG CCL11 TNF TRPV1
34 viral hepatitis 29.8 ALB TLR9 TNF
35 anorexia nervosa 29.5 CCK GHRL PYY
36 eosinophilic enteropathy 11.4
37 gastritis, familial giant hypertrophic 11.1
38 esophageal atresia/tracheoesophageal fistula 10.9
39 mucositis 10.9
40 appendix disease 10.9
41 peritonitis 10.9
42 lactase deficiency, congenital 10.8
43 selective igm deficiency disease 10.7
44 diverticulitis 10.7
45 cerebral creatine deficiency syndrome 1 10.7
46 platelet-activating factor acetylhydrolase deficiency 10.7
47 whipple disease 10.7
48 median arcuate ligament syndrome 10.7
49 male reproductive system disease 10.4 AREG TLR9 TRPV1
50 bile reflux 10.4 ATP12A ATP4A CCK

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to Gastrointestinal System Disease

Symptoms & Phenotypes for Gastrointestinal System Disease

UMLS symptoms related to Gastrointestinal System Disease:


nausea and vomiting, constipation, vomiting, abdominal pain, diarrhea, nausea, flatulence, abdominal bloating, icterus, signs and symptoms, digestive, rectal tenesmus, decrease in appetite, dyspepsia, heartburn, gastrointestinal gas, anal discomfort, halitosis, oral manifestations, digestive system symptom, vomiting alone, catarrh, flatulence, eructation, and gas pain, symptoms involving digestive system, other symptoms involving digestive system, odynophagia, swallowing problems, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, glossalgia, gastric irritation, abdominal cramps, abdomen, acute, eructation, rectal pain, liver tender, abdominal discomfort, upper abdominal pain, lower abdominal pain, retching, dry throat, hyperemesis, abdominal distress, epigastric pain not food-related, right upper quadrant pain, epigastric food-related pain, upset stomach, abdominal fullness, salivary gland pain, abdominal distention, gaseous, anal pain, infantile colic, vomiting in newborn, change in bowel habits, stomach cramps (finding), gastrointestinal symptoms, sore lip, gastrointestinal pain, abdominal distress/pain as reason for lower g.i. examination, abdominal distress/pain as reason for upper g.i. examination, epigastric discomfort, blood in stool, peeling tongue

GenomeRNAi Phenotypes related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB ATP4A CCKAR CCL15 GHRL HTR4

MGI Mouse Phenotypes related to Gastrointestinal System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.61 ALB AREG ATP12A ATP4A CCKAR GAST
2 homeostasis/metabolism MP:0005376 9.44 ALB AREG ATP12A ATP4A CCK CCKAR

Drugs & Therapeutics for Gastrointestinal System Disease

Drugs for Gastrointestinal System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1428)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimebutine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 39133-31-8
2
Rabeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 117976-89-3 5029
3
Indomethacin Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable 53-86-1 3715
4
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 501-36-0 445154
5
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 443-48-1 4173
6
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
7 tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
8
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 616-91-1 12035
9
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
10
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 69-65-8 453 6251
11
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
12
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
13
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 26787-78-0 33613
14
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492
15
Amlodipine Approved Phase 4,Phase 1,Phase 2 88150-42-9 2162
16
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
17
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
18
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
19 Orange Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1406-66-2 14986
21
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53608-75-6
22
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 437-38-7 3345
24
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 170277-31-3
25
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
26
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
27
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 113775-47-6 68602 5311068
28
Milk thistle Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 65666-07-1
29 Nefopam Approved, Investigational Phase 4,Not Applicable 13669-70-0
30
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 27203-92-5 33741
31
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 84057-95-4 175805 71273
32
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1 4205-90-7 2803
33
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56030-54-7 41693
34
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
35
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 24280-93-1 446541
36
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 55-56-1 2713 9552079
37
Meropenem Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 119478-56-7 64778 441130
38
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
39
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51110-01-1, 38916-34-6 53481605
40
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Not Applicable 163222-33-1 150311
41
Propranolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 525-66-6 4946
42
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
43
Nadolol Approved Phase 4,Phase 3 42200-33-9 39147
44
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 73590-58-6 4594
45
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
46
Carvedilol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 72956-09-3 2585
47
Vancomycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1404-90-6 14969 441141
48
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 6740-88-1 3821
49
Remifentanil Approved Phase 4,Phase 2,Not Applicable 132875-61-7 60815
50
Rifaximin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 80621-81-4 6436173

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole Unknown status NCT02986685 Phase 4 Trimebutine Maleate;rabeprazole
2 Oral Resveratrol to Prevent Post-ERCP Pancreatitis Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
3 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
4 Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis Unknown status NCT02962245 Phase 4 berberine;regular treatment
5 Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study Unknown status NCT01737463 Phase 4
6 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4 N-acetylcysteine
7 Prospective Random Comparing Study on EUS-guided Pseudocyst Drainage by Naso-pancreatic Tube and Stents Unknown status NCT01585662 Phase 4
8 Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral Tubing Unknown status NCT02998112 Phase 4 fecal microbiota transplantation;Saline
9 Mast Cells in Acid-induced Intestinal Permeability Unknown status NCT02664051 Phase 4 Nalcrom;placebo
10 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
11 Diverticulitis: Antibiotics or Close Observation? Unknown status NCT01111253 Phase 4 Amoxicillin-clavulanate
12 Double- Versus Single-balloon Enteroscopy for Obscure Small-bowel Bleeding Unknown status NCT01176864 Phase 4
13 Influence of CYP3A5 Polymorphism on Liver Function Abnormality and the Trough Level Change After Conversion Unknown status NCT02882113 Phase 4 Advagraf
14 Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease Unknown status NCT02366845 Phase 4
15 Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease Unknown status NCT02213224 Phase 4 Perindopril;Telmisartan;Amlodipine
16 The Effect Of Dual Treatment With L-Carnitine And Magnesium On Fatty Liver Unknown status NCT01956825 Phase 4
17 The Orange-III Trial: Optimised Recovery With Movicol® Preoperatively Within an Enhanced Recovery Programme Unknown status NCT01429779 Phase 4 Movicol
18 Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease Unknown status NCT00941642 Phase 4 Lovaza;placebo control
19 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
20 A Study of Thymoglobulin and Tacrolimus in Liver Transplant Unknown status NCT00564538 Phase 4 anti-thymocyte globulin (rabbit);tacrolimus
21 Intravenous-Morphine and Glucagon-Usage Enhanced MR Cholangiography Unknown status NCT00155376 Phase 4 morphine and glucagon
22 Analgesic Efficacy of Intravenous Hyoscine-N-Butylbromide (HNB) in Abdominal Colic Associated With Acute Gastroenteritis Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
23 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
24 COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
25 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
26 Branched-chain Amino Acid (BCAA) on Progression of Advanced Liver Disease Unknown status NCT02837302 Phase 4 Livact
27 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
28 Complex Imaging Assessment of Steatosis Unknown status NCT02669641 Phase 4
29 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
30 Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
31 TO Compare the Triple Drug Therapy and Dual Therapy . Unknown status NCT02075242 Phase 4 Mycophenolate Mofetil;Tacrolimus
32 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
33 Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01950884 Phase 4 Ezetimibe
34 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
35 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
36 A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol Unknown status NCT01298284 Phase 4 propranolol
37 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4 Esomeprazole;esomeprazole
38 Single-Operator Versus Dual-Operator Double-balloon Endoscopy in Patients With Small-Bowel Disorders Unknown status NCT01184690 Phase 4
39 Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding Unknown status NCT00567216 Phase 4 Nadolol
40 Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding Unknown status NCT00861640 Phase 4 Intravenous Omeprazole;Oral Rabeprazole
41 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
42 FEcal Transplant, a Hope to Eradicate Colonization of Patient Harboring eXtreme Drug Resistant Bacteria? Unknown status NCT03029078 Phase 4 fecal microbiota transplant
43 Vitamin D Substitution During Winter Time Unknown status NCT02958501 Phase 4 Colecalciferol
44 Anemia in Inflammatory Bowel Disease Unknown status NCT02760940 Phase 4 oral liposomal iron
45 The Effect of Hepatic Vein Pressure Gradient(HVPG)-Guided Therapy in Cirrhotic Patients With Esophagogastric Varices Unknown status NCT02638415 Phase 4 Carvedilol
46 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
47 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
48 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
49 Rifaximin Predicts the Complications of Decompensated Cirrhosis Unknown status NCT02074280 Phase 4 rifaximin
50 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo

Search NIH Clinical Center for Gastrointestinal System Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: digestive system diseases

Genetic Tests for Gastrointestinal System Disease

Anatomical Context for Gastrointestinal System Disease

MalaCards organs/tissues related to Gastrointestinal System Disease:

41
Testes, Liver, Colon, Small Intestine, Pancreas, Bone, Tongue

The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal System Disease:

19
The Gastrointestinal Tract

Publications for Gastrointestinal System Disease

Articles related to Gastrointestinal System Disease:

(show top 50) (show all 682)
# Title Authors Year
1
Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases. ( 30454658 )
2019
2
Diet and the Role of Food in Common Gastrointestinal Diseases. ( 30466667 )
2019
3
Eosinophilic Gastrointestinal Diseases (EGIDs) beyond Eosinophilic Esophagitis (EoE). ( 29940308 )
2018
4
Quantifying the effects of aging and urbanization on major gastrointestinal diseases to guide preventative strategies. ( 30285652 )
2018
5
Eosinophilic Esophagitis and the Eosinophilic Gastrointestinal Diseases: Approach to Diagnosis and Management. ( 30201096 )
2018
6
Patch testing in gastrointestinal diseases - a systematic review of the patch test and atopy patch test. ( 29524260 )
2018
7
Development of IgE-mediated immediate hypersensitivity to a previously tolerated food following its avoidance for eosinophilic gastrointestinal diseases. ( 28958748 )
2018
8
Functional Diagnosis in Upper and Lower Gastrointestinal Diseases: Relevance for Conservative, Interdisciplinary and Surgical Therapies. ( 29888244 )
2018
9
Are We Close to Targeting Enteric Glia in Gastrointestinal Diseases and Motility Disorders? ( 29964042 )
2018
10
Gastrointestinal diseases during pregnancy: what does the gastroenterologist need to know? ( 29991883 )
2018
11
Recent advances in probiotics as live biotherapeutics against gastrointestinal diseases. ( 30014799 )
2018
12
Epigenetics of gastrointestinal diseases: notes from a workshop. ( 30056798 )
2018
13
Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review. ( 30062750 )
2018
14
An automated identification and analysis of ontological terms in gastrointestinal diseases and nutrition-related literature provides useful insights. ( 30065857 )
2018
15
Information Seeking Source among Patient with Gastrointestinal Diseases and Functional Gastrointestinal Disorders. ( 30087884 )
2018
16
Application of Electronic-Nose Technologies and VOC-Biomarkers for the Noninvasive Early Diagnosis of Gastrointestinal Diseases †. ( 30096939 )
2018
17
Diagnostic value of chemerin in lower gastrointestinal diseases-a review. ( 30165089 )
2018
18
Prevalence and risk factors for upper gastrointestinal diseases in health check-up subjects: a nationwide multicenter study in Korea. ( 30169983 )
2018
19
Helicobacter pylori and nonmalignant upper gastrointestinal diseases. ( 30203583 )
2018
20
High-Salt Diet Gets Involved in Gastrointestinal Diseases through the Reshaping of Gastroenterological Milieu. ( 30293081 )
2018
21
Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors. ( 30319695 )
2018
22
Circadian rhythms in the pathogenesis of gastrointestinal diseases. ( 30344415 )
2018
23
Image-Enhanced Endoscopy in Lower Gastrointestinal Diseases: Present and Future. ( 30508878 )
2018
24
Role of Inflammasomes in the Development of Gastrointestinal Diseases. ( 30536174 )
2018
25
Exosomes as a novel cell-free therapeutic approach in gastrointestinal diseases. ( 30536895 )
2018
26
Endocannabinoid-related compounds in gastrointestinal diseases. ( 28990365 )
2018
27
Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics. ( 29184185 )
2018
28
Decreased plasma amino acid concentrations in cats with chronic gastrointestinal diseases and their possible contribution in the inflammatory response. ( 29249312 )
2018
29
Understanding the Burden of Pediatric Gastrointestinal Diseases-Does a Look From the Perspective of Inpatient Administrative Databases Help? ( 29269197 )
2018
30
Techniques and Accuracy of Abdominal Ultrasound in Gastrointestinal Diseases of Horses and Foals. ( 29402481 )
2018
31
Fully-covered metal stents with endoscopic suturing vs. partially-covered metal stents for benign upper gastrointestinal diseases: a comparative study. ( 29404384 )
2018
32
Nutritional Management of Gastrointestinal Diseases. ( 29413028 )
2018
33
Functional gastrointestinal diseases and psychological maladjustment, personality traits and quality of life. ( 29486708 )
2018
34
Advances in the Diagnosis and Management of Equine Gastrointestinal Diseases. ( 29534811 )
2018
35
How are the expression patterns of gut antimicrobial peptides modulated by human gastrointestinal diseases? A bridge between infectious, inflammatory, and malignant diseases. ( 29542263 )
2018
36
New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases. ( 29614417 )
2018
37
New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting. ( 29803797 )
2018
38
Prevalence of Helicobacter pylori cagA and iceA Genes and Their Association with Gastrointestinal Diseases. ( 29849647 )
2018
39
Biological therapies for eosinophilic gastrointestinal diseases. ( 29859203 )
2018
40
Functional Diagnosis in Upper and Lower Gastrointestinal Diseases: Relevance for Conservative, Interdisciplinary and Surgical Therapies. ( 29888235 )
2018
41
Retraction: Adult tissue stem cell therapy for gastrointestinal diseases by Mamoru Watanabe. ( 24547965 )
2018
42
Helicobacter pylori virulence factors in relation to gastrointestinal diseases in Iran. ( 28232251 )
2017
43
Gastrointestinal diseases and their oro-dental manifestations: Part 4: Peutz-Jeghers syndrome. ( 28184053 )
2017
44
Gastrointestinal diseases and their oro-dental manifestations: Part 2: Ulcerative colitis. ( 28084352 )
2017
45
Effects of Pediatric Burns on Gastrointestinal Diseases: A Population-Based Study. ( 28253212 )
2017
46
Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance. ( 27907913 )
2017
47
Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases. ( 27915988 )
2017
48
Utility of a multidisciplinary tumor board in the management of pancreatic and upper gastrointestinal diseases: an observational study. ( 27916436 )
2017
49
Gastrointestinal diseases and their oro-dental manifestations: Part 3: Coeliac disease. ( 28126998 )
2017
50
Review of the role of probiotics in gastrointestinal diseases in adults. ( 28185664 )
2017

Variations for Gastrointestinal System Disease

Expression for Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for Gastrointestinal System Disease

GO Terms for Gastrointestinal System Disease

Cellular components related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALB CCK CCL11 CCL15 GAST GCG
2 extracellular space GO:0005615 9.44 ALB AREG ATP4A CCK CCL11 CCL15

Biological processes related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 CCK CCKAR CCL11 CCL15 GAST GCG
2 immune response GO:0006955 9.85 CCL11 CCL15 MADCAM1 TLR9 TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 CCL11 CCL15 GCG TNF
4 G protein-coupled receptor signaling pathway GO:0007186 9.73 AREG CCK CCKAR CCL11 CCL15 GAST
5 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.69 CCK S100A8 TNF
6 neutrophil chemotaxis GO:0030593 9.67 CCL11 CCL15 S100A8
7 inflammatory response GO:0006954 9.63 CCL11 CCL15 S100A8 TLR9 TNF TRPV1
8 positive regulation of inflammatory response GO:0050729 9.61 S100A8 TLR9 TNF
9 cellular sodium ion homeostasis GO:0006883 9.56 ATP12A ATP4A
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.55 ATP12A ATP4A
11 cellular potassium ion homeostasis GO:0030007 9.54 ATP12A ATP4A
12 sodium ion export across plasma membrane GO:0036376 9.52 ATP12A ATP4A
13 feeding behavior GO:0007631 9.43 CCKAR GCG PYY
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.4 TLR9 TNF
15 chronic inflammatory response GO:0002544 9.37 CCL11 S100A8
16 regulation of signaling receptor activity GO:0010469 9.36 AREG CCK CCL11 CCL15 GAST GCG

Molecular functions related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 AREG CCL11 CCL15 TNF
2 G protein-coupled receptor binding GO:0001664 9.33 GHRL PYY SCT
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP12A ATP4A
4 hormone activity GO:0005179 9.17 CCK GAST GCG GHRL MLN PYY
5 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Gastrointestinal System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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