MCID: GST050
MIFTS: 56

Gastrointestinal System Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Disease

MalaCards integrated aliases for Gastrointestinal System Disease:

Name: Gastrointestinal System Disease 12 15
Gastrointestinal Diseases 54 71
Gastrointestinal Disease 12 17
Gastrointestinal Disorders 15
Digestive System Disorders 71
Alimentary System Disease 12
Digestive System Disorder 12
Gastrointestinal Disorder 12
Digestive System Diseases 43
Digestive System Disease 17
Gastroenteropathy 12
Git Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:77
ICD9CM 34 520-579.99
MeSH 43 D004066
SNOMED-CT 67 53619000
ICD10 32 11 K92.8 K92.9
UMLS 71 C0012242 C0017178

Summaries for Gastrointestinal System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the gastrointestinal tract.

MalaCards based summary : Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to intestinal disease and stomach disease, and has symptoms including nausea and vomiting, constipation and vomiting. An important gene associated with Gastrointestinal System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. The drugs Indomethacin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include gastrointestinal tract, liver and testes.

Wikipedia : 74 Gastrointestinal diseases (abbrev. GI diseases or GI illnesses) refer to diseases involving the... more...

Related Diseases for Gastrointestinal System Disease

Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1043)
# Related Disease Score Top Affiliating Genes
1 intestinal disease 33.1 SERPINA3 MIR518A1 MIR31 MIR21 MIR199A1 MIR196A1
2 stomach disease 33.1 SERPINA3 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
3 mouth disease 33.1 SERPINA3 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
4 esophageal disease 33.1 MIR21 MIR199A1 MIR196A1 MIR17 MIR145 MIR143
5 gallbladder disease 33.0 SERPINA3 MLN MIR199A1 MIR17 MIR145 MIR143
6 gastrointestinal ulceration, recurrent, with dysfunctional platelets 32.8 S100A8 GAST
7 pancreas disease 31.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
8 biliary tract disease 31.7 SERPINA3 MIR31 MIR199A1 MIR196A1 MIR17 MIR145
9 connective tissue disease 31.6 SERPINA3 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
10 tongue disease 31.6 MIR21 MIR199A1 MIR196A1 MIR17 MIR145 CCR6
11 celiac disease 1 31.6 ICOSLG H2AC18 GAST CCR6 CCK
12 colonic disease 31.5 MIR31 MIR21 MIR199A1 MIR196A1 MIR17 MIR145
13 pancreatic cancer 31.4 MIR21 MIR199A1 MIR196A1 MIR17 MIR145 MIR143
14 esophageal cancer 31.4 MIR31 MIR21 MIR199A1 MIR196A1 MIR145 MIR143
15 duodenitis 31.3 S100A8 GAST CCK
16 salivary gland disease 31.3 SERPINA3 ICOSLG H2AC18 CCR6
17 colorectal cancer 31.3 MIR31 MIR21 MIR199A1 MIR196A1 MIR17 MIR145
18 gastric cancer 31.3 SERPINA3 S100A8 MIR31 MIR21 MIR199A1 MIR196A1
19 body mass index quantitative trait locus 11 31.3 SERPINA3 MLN MIR21 MIR199A1 MIR196A1 MIR17
20 gastroparesis 31.2 MLN GAST CCK
21 myeloma, multiple 31.2 MIR21 MIR199A1 MIR196A1 MIR17 MIR126 ICOSLG
22 gastrointestinal system cancer 31.2 SERPINA3 MIR518A1 MIR31 MIR21 MIR199A1 MIR196A1
23 systemic scleroderma 31.2 MLN MIR21 ICOSLG H2AC18 GAST CCR6
24 peripheral nervous system disease 31.2 SERPINA3 MIR21 MIR126 ICOSLG H2AC18 CCR6
25 collagen disease 31.2 SERPINA3 MIR21 ICOSLG H2AC18 CCR6
26 non-alcoholic fatty liver disease 31.2 MIR31 MIR21 MIR17 MIR126 MIR122
27 hepatocellular carcinoma 31.1 SERPINA3 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
28 skin disease 31.1 SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR126
29 duodenal ulcer 31.1 S100A8 MLN GAST CCK
30 microinvasive gastric cancer 31.1 S100A8 MIR196A1 GAST
31 exanthem 31.0 ICOSLG H2AC18 CCR6
32 psoriasis 31.0 S100A8 MIR31 MIR21 MIR17 MIR122 CCR6
33 rectum cancer 31.0 MIR518A1 MIR31 MIR21 MIR196A1 MIR17 MIR145
34 colorectal adenoma 31.0 MIR21 MIR17 APC
35 mikulicz disease 31.0 ICOSLG CCR6
36 dermatitis, atopic 30.9 SERPINA3 MIR21 ICOSLG H2AC18 CCR6
37 neuromuscular disease 30.9 SERPINA3 ICOSLG H2AC18 CCR6
38 constipation 30.9 MLN HTR4 GAST CCK
39 bacterial infectious disease 30.9 SERPINA3 ICOSLG H2AC18 CCR6
40 autonomic neuropathy 30.9 MLN GAST CCK
41 cholangitis, primary sclerosing 30.9 MIR145 ICOSLG CCR6
42 irritable bowel syndrome 30.9 MLN HTR4 CCK
43 lung cancer 30.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR196A1 MIR17
44 arteries, anomalies of 30.9 SERPINA3 MIR21 MIR199A1 MIR196A1 MIR17 MIR145
45 bile reflux 30.9 S100A8 GAST CCK
46 duodenum disease 30.9 S100A8 MIR196A1 GAST
47 duodenogastric reflux 30.9 MLN GAST CCK
48 gastroesophageal reflux 30.9 S100A8 MLN GAST CCK
49 bone resorption disease 30.9 MIR199A1 H2AC18 CCR6
50 dumping syndrome 30.8 MLN GAST CCK

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to Gastrointestinal System Disease

Symptoms & Phenotypes for Gastrointestinal System Disease

UMLS symptoms related to Gastrointestinal System Disease:


nausea and vomiting, constipation, vomiting, abdominal pain, diarrhea, nausea, halitosis, abdominal bloating, icterus, signs and symptoms, digestive, rectal tenesmus, decrease in appetite, dyspepsia, heartburn, gastrointestinal gas, anal discomfort, oral manifestations, digestive system symptom, vomiting alone, catarrh, flatulence, eructation, and gas pain, symptoms involving digestive system, other symptoms involving digestive system, odynophagia, swallowing problems, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, glossalgia, gastric irritation, abdominal cramps, abdomen, acute, eructation, flatulence, rectal pain, liver tender, abdominal discomfort, upper abdominal pain, lower abdominal pain, retching, dry throat, hyperemesis, abdominal distress, epigastric pain not food-related, right upper quadrant pain, epigastric food-related pain, upset stomach, abdominal fullness, salivary gland pain, abdominal distention, gaseous, anal pain, infantile colic, vomiting in newborn, change in bowel habits, stomach cramps (finding), gastrointestinal symptoms, sore lip, gastrointestinal pain, abdominal distress/pain as reason for lower g.i. examination, abdominal distress/pain as reason for upper g.i. examination, epigastric discomfort, blood in stool, peeling tongue

Drugs & Therapeutics for Gastrointestinal System Disease

Drugs for Gastrointestinal System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 584)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
2
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
3
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
4
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
5
Perphenazine Approved Phase 4 58-39-9 4748
6
Amitriptyline Approved Phase 4 50-48-6 2160
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
9
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
12
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
13
Clarithromycin Approved Phase 4 81103-11-9 84029
14
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
15
Bisacodyl Approved Phase 4 603-50-9
16
Prucalopride Approved Phase 4 179474-81-8
17
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
18
Mebeverine Approved, Investigational Phase 4 3625-06-7 62887
19
Alverine Approved, Investigational Phase 4 150-59-4 3678
20
Simethicone Approved Phase 4 8050-81-5
21
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
22
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
23
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
24
leucovorin Approved Phase 4 58-05-9 6006 143
25
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
26
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
27
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
28
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
29
Potassium citrate Approved, Investigational, Vet_approved Phase 4
30
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
31
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
32
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
33
Loperamide Approved Phase 4 53179-11-6 3955
34
Bismuth subsalicylate Approved, Vet_approved Phase 4 14882-18-9 53629521
35
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
36
Racepinephrine Approved Phase 4 329-65-7 838
37
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
38
Sodium citrate Approved, Investigational Phase 4 68-04-2
39
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
41
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
42
Azithromycin Approved Phase 4 83905-01-5 55185 447043
43
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
44
Ustekinumab Approved, Investigational Phase 4 815610-63-0
45
Calcium carbonate Approved, Investigational Phase 4 471-34-1
46 Vedolizumab Approved Phase 4 943609-66-3
47
Pancrelipase Approved, Investigational Phase 4 53608-75-6
48
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
49
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
50
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 6433735 5283731

Interventional clinical trials:

(show top 50) (show all 863)
# Name Status NCT ID Phase Drugs
1 The Treatment of Periodontal Diseases. A Randomized, Blinded, Five Years Follow-up, Four-arm, Placebo Controlled Clinical Intervention Trial Unknown status NCT01318928 Phase 4 Metronidazol
2 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Continuing or Discontinuing on Aspirin: a Multicenter, Double-blind, Placebo-controlled, Randomized Clinical Trial Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
3 Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
4 Phase 4 Study of Helicobacter Pylori Eradication Therapy Unknown status NCT00990405 Phase 4 Lansoprzole+Amoxicillin+Clarithromycin
5 EVALUATION OF THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS IN HEAD AND NECK CANCER PATIENTS Unknown status NCT02241876 Phase 4 N-acetylcysteine
6 Randomized Controlled Trial Testing the Effect of Milk Formula Supplemented With L. Reuteri on Crying Time in Colicky Infants Less Than 3 Months Old Unknown status NCT02430831 Phase 4
7 Spectrum of Gastrointestinal Microbiota in Patients With IBS-D Before and After Treatment With VSL#3. Unknown status NCT01638208 Phase 4 VSL#3
8 Glucomannn for the Treatment of Abdominal Pain-related Functional Gastrointestinal Disorders in Childhood Randomized Double Blind Placebo Controlled Trial Completed NCT01495806 Phase 4 Glucomannan;placebo
9 Evaluation of the Effects of Enterogermina, 2 Billion Bacillus Clausii Spores, on the Intestinal Flora of Children Antibiotic Treated for Bacterial Upper Respiratory Tract Infections: Open, Pilot Study. Completed NCT00424905 Phase 4 Bacillus clausii
10 Comparison of the Eradication Rate Between 1- and 2-Week PPI Containing Therapies for Helicobacter Pylori Eradication Completed NCT02487511 Phase 4
11 Evaluation of the Efficacy of Amitriptyline in Children With Abdominal Pain of Non-Organic Origin Completed NCT00564525 Phase 4 Amitriptyline;Placebo
12 A Multicentre, Randomised, Double-Blind, Placebo Controlled, Crossover Trial On The Efficacy Of A Mixture Of Three Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders Completed NCT02566876 Phase 4 Mixture of three Bifidobacteria
13 Clinical Use of an Absorbable Coated Suture Material in Surgery (Safil) One Layer Running(A) vs. Two-Layer Suture Technique (B) Completed NCT00645684 Phase 4
14 A Randomised, Multicentre, Single-Blind, Phase IV Study, of the Efficacy, Safety, and Acceptability of Moviprep® Versus Colopeg® in Colonoscopy Preparation. Completed NCT00605228 Phase 4 MOVIPREP;COLOPEG
15 Comparative Randomized, Single Dose, Two-way Crossover Open-label Study to Determine the Bioequivalence of Rabeprazole From Raperazole 20mg DR Tabs (GSK, Egypt) and PARIET 20 mg DR Tabs (JANSSEN, EGYPT) After a Single Oral Dose Administration of Each to Healthy Adults Under Fed Conditions Completed NCT02605395 Phase 4 IDIAZOLE 20mg DR tabs;PARIET 20 mg DR tabs
16 Comparative Randomized, Single Dose, Two-way Crossover Open-label Study to Determine the Bioequivalence of Rabeprazole From Idiazole 20mg DR Tabs (GSK, Egypt)and PARIET 20 mg DR Tabs (JANSSEN, EGYPT) After a Single Oral Dose Administration of Each to Healthy Adults Under Fasting Conditions Completed NCT02446483 Phase 4 Idiazole 20mg DR tabs;PARIET 20 mg DR tabs
17 The Effects of Fentanyl and Alfentanil as an Adjunct to Propofol on Cognitive Functions for Sedation in Colonoscopy Completed NCT02267681 Phase 4 Fentanyl;Alfentanil;Propofol
18 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease: a Placebo-controlled Randomized Trial Completed NCT02010762 Phase 4 Vitamin D;Placebo
19 Randomized Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
20 Assistance Robotics for the Surgical Treatment of the Abdominal Wall Hernia Completed NCT00908193 Phase 4
21 The Efficacy of Mutaflor(E. Coli Nissle 1917, Mutaflor®) for Chronic Constipation:Multicenter Study Completed NCT02726295 Phase 4 E. coli Nissle 1917(Mutaflor®);Placebo
22 The Effect of Esomeprazole (Nexium) on the Incidence and Severity of Gastrointestinal Adverse Events Associated With a Colonoscopy Purgative Completed NCT00225238 Phase 4 esomeprazole (PPI)
23 Efficacy and Tolerability of α-galactosidase in Treating Gas-related Symptoms in Children. A Randomized, Double-blind, Placebo-controlled Trial Completed NCT01595932 Phase 4
24 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Without Comorbid Major Depressive Disorder Completed NCT00401258 Phase 4 duloxetine
25 An Open Observational Study For The Rabeprazole Administration In Adult Subjects With Helicobacter Pylori (H. Pylori) Infection Completed NCT00216450 Phase 4 rabeprazole sodium
26 The Effect of Korean Red Ginseng Supplementation on Glucose Control in Subjects With Impaired Fasting Glucose, Impaired Glucose Tolerance or Newly-diagnosed Type 2 Diabetes Mellitus Completed NCT01911663 Phase 4
27 An Open-label, Randomised, Crossover, Reader Blinded, Study to Compare the Effect of Polyethylene Glycol 3350, Bisacodyl and Prucalopride on Colonic Motility Assessed With Intraluminal Colonic Manometry in Healthy Subjects Completed NCT03279341 Phase 4 polyethylene glycol;Bisacodyl;Prucalopride
28 Open, Single Centre, Pilot Study to Investigate a Steroid Free Immunosuppressive Regimen for De Novo Renal Transplant Recipients Followed by Randomisation to Calcineurin Inhibitor Containing or Calcineurin Inhibitor Free Immunosuppression Completed NCT00306397 Phase 4 Rapamycin
29 Comparison of the I-gel Laryngeal Mask and the Classic Laryngeal Mask in Patients With a BMI>25 During Elective Surgery Completed NCT01003327 Phase 4
30 Metronidazole for the Treatment of Dientamoebiasis in Children in Denmark - A Randomized, Placebo-controlled, Double-blinded Clinical Trial Completed NCT01314976 Phase 4 Metronidazole;Placebo
31 Effect of Proton Pump Inhibitor on Gastric Emptying and Satiety Function in Patients With Functional Dyspepsia Completed NCT00951431 Phase 4 Esomeprazole;Placebo
32 Efficacy of the Combination Therapy With Alverine-simeticone and i3.1 Probiotic Formula in the Quality of Life of Patients With IBS-D or IBS-M in Hospital Juarez Mexico Completed NCT04145856 Phase 4
33 Efficacy of Calcifediol Supplementation in Asthma Control in Asthmatic Patients With Vitamin D Deficiency (ACViD) Completed NCT02805907 Phase 4 Calcifediol;Placebo
34 Absorption of Orally Ingested Phosphate in Head and Neck Cancer Patients With and Without Refeeding Syndrome Completed NCT02880072 Phase 4
35 Short Protocol Barostat for Assessment of Anorectal Function Versus Standard Protocol Barostat in Healthy Volunteers Completed NCT01456442 Phase 4
36 Comparing With Traditional Nitrogen Calorie Parenteral Nutrition Support, the Impact of Low Calorie and Low Nitrogen Intake on the Clinical Outcome of Gastrointestinal Postoperative Patients, Multicentre Post-Marketing Clinical Study Completed NCT00247338 Phase 4 low calorie, low nitrogen parenteral nutrition for patient with NRS score 3
37 Single-Site, Double-Blind, Flexible-Dose, Placebo-Controlled Study of the Efficacy, Tolerability, & Safety of Paroxetine - Controlled Release in the Treatment of Irritable Bowel Syndrome (IBS) Completed NCT00610909 Phase 4 Paroxetine CR;Placebo
38 Role of Gastroesophageal Acid Reflux at Squamo-columnar Junction in Functional Dyspepsia Completed NCT01349413 Phase 4 Esomeprazole 20mg
39 A Greek, Single Center, Randomized, Double Blind Controlled Clinical Study Comparing the 10-day Versus the 14-day Concomitant Proton Pump Inhibitor [PPI] + Amoxicillin + Metronidazole + Clarithromycin (PAMC) Therapeutic Scheme as First-line Treatment Strategy for the Eradication of H. Pylori Infection Completed NCT02959255 Phase 4 Esomeprazole
40 Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial Completed NCT02794506 Phase 4 Propolis;Placebo
41 Metabolic and Vascular Effects of Silybin in Hypertensive Patients With High One-hour Post-load Plasma Glucose: a Single Arm Pilot Study Completed NCT03538327 Phase 4 Silybin
42 Opioid Free Versus Opioid Balanced Anesthesia in Middle Ear Surgery. Completed NCT03809949 Phase 4 Fentanyl Opioid anesthesia;Saline Nonopioid anesthesia
43 The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers Completed NCT02736734 Phase 4 CRH
44 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption, Cognitive Function and Incidence of Neuropathic Pain in Laparoscopic Intestine Resection Completed NCT02616523 Phase 4 Dexmedetomidine;Lidocaine;Fentanyl
45 The Safety and Immunogenicity of 10μg/0.5ml Recombinant Hepatitis B Vaccines(Saccharomyces Cerevisiae) in the Healthy Neonates Recruiting NCT02764671 Phase 4
46 Conversion From MPA to Zortress (Everolimus) for GI Toxicity Post-renal Transplantation Recruiting NCT02974686 Phase 4 Everolimus;Mycophenolic Acid
47 The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers: A Randomized, Parallel-controlled Multi-center Study Recruiting NCT03342456 Phase 4 Doxycycline Hyclate Enteric-Coated Capsules;Amoxicillin Capsules;Ilaprazole Enteric-Coated Tablets;Furazolidone Tablets;Potassium Citrate Tablets
48 Celiac Disease and Vitamin Status: Evaluation of the Effect of Supplementation With a Probiotic (VIVOMIXX®) on Vitamin B6, B12, 25'OH D, Folic Acid and Omocystein Levels, Metabolic and Inflammatory Status, and Gut Microbiota Metabolomics in a Cohoort of Celiac Patients Recruiting NCT04160767 Phase 4 Probiotic Vivomixx
49 Reduction of Postoperative Gastrointestinal Dysmotility Following Total Laparoscopic Hysterectomy: a Randomized Control Trial. Recruiting NCT03800745 Phase 4 Colace 100Mg Capsule;Miralax
50 Prebiotic Treatment in People With Schizophrenia (preFOCIS) Recruiting NCT03617783 Phase 4 Prebiotin;Placebo

Search NIH Clinical Center for Gastrointestinal System Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Belladonna Alkaloids
belladonna extract, USP
BELLADONNA LEAF
Dicyclomine
Dicyclomine Hydrochloride
prednisolone
prednisolone acetate
PREDNISOLONE ACETATE PWDR
PREDNISOLONE PWDR
Prednisolone sodium phosphate
prednisolone tebutate
Prednisone
PREDNISONE PWDR
Sacrosidase

Cochrane evidence based reviews: digestive system diseases

Genetic Tests for Gastrointestinal System Disease

Anatomical Context for Gastrointestinal System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal System Disease:

19
Gastrointestinal Tract

MalaCards organs/tissues related to Gastrointestinal System Disease:

40
Liver, Testes, Colon, Bone, Small Intestine, Pancreas, Heart

Publications for Gastrointestinal System Disease

Articles related to Gastrointestinal System Disease:

(show top 50) (show all 4563)
# Title Authors PMID Year
1
The vanilloid receptor TRPV1: role in cardiovascular and gastrointestinal protection. 54 61
19879868 2010
2
Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review). 54 61
19885611 2009
3
Lactoferrin in gastrointestinal disease. 54 61
19652425 2009
4
Application of ghrelin to gastrointestinal diseases. 54 61
18821473 2008
5
Cholecystokinin. 54 61
17940422 2007
6
Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases. 54 61
17181989 2006
7
Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases. 54 61
16937534 2006
8
Tissue distribution and plasma clearance of heparin-binding EGF-like growth factor (HB-EGF) in adult and newborn rats. 54 61
16364500 2006
9
Circulating ghrelin levels in patients with various upper gastrointestinal diseases. 54 61
15906753 2005
10
Immunohistochemical distribution of vanilloid receptor, calcitonin-gene related peptide and substance P in gastrointestinal mucosa of patients with different gastrointestinal disorders. 54 61
16259736 2005
11
Topographical localisation of cagA positive and cagA negative Helicobacter pylori strains in the gastric mucosa; an in situ hybridisation study. 54 61
15280402 2004
12
T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice. 54 61
15236177 2004
13
cagA and vacA genotype of Helicobacter pylori associated with gastric diseases in Xi'an area. 54 61
12918116 2003
14
Involvement of cholecystokinin/gastrin-related peptides and their receptors in clinical gastrointestinal disorders. 54 61
12688377 2002
15
Combination of HCGbeta, CA 19-9 and CEA with logistic regression improves accuracy in gastrointestinal malignancies. 54 61
12168865 2002
16
[Helicobacter pylori genotypes in non atrophic gastritis are different of the found in peptic ulcer, premalignant lesions and gastric cancer in Colombia]. 54 61
11974526 2002
17
ALX-0600 (NPS Allelix Corp). 54 61
11566007 2001
18
Association of Helicobacter pylori genotype with gastroesophageal reflux disease and other upper gastrointestinal diseases. 54 61
10710054 2000
19
Direct determination of Helicobacter pylori vacA genotypes and cagA gene in gastric biopsies and relationship to gastrointestinal diseases. 54 61
10364019 1999
20
High frequency of cytotoxin-associated gene A in Helicobacter pylori isolated from asymptomatic subjects and peptic ulcer patients in Taiwan. 54 61
9706771 1998
21
[Measurement of fecal lactoferrin for diagnosis on pediatric gastrointestinal disease]. 54 61
9437905 1997
22
A multicentre evaluation of tumour marker determinations using the automatic Enzymun-Test Systems ES 300 and ES 600/700. 54 61
8704058 1996
23
Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse. 54 61
7759110 1995
24
Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini. 54 61
1995267 1991
25
Fecal isoamylase activity in patients with pancreatic diseases. 54 61
1704633 1991
26
Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response. 61
31922249 2020
27
Galloyl flavonoids from Acacia farnesiana pods possess potent anthelmintic activity against Haemonchus contortus eggs and infective larvae. 61
31739102 2020
28
Organoid-based regenerative medicine for inflammatory bowel disease. 61
31970266 2020
29
Porcine Deltacoronavirus Infection and Transmission in Poultry, United States1. 61
31961296 2020
30
Sophora alopecuroides L.: An ethnopharmacological, phytochemical, and pharmacological review. 61
31442619 2020
31
Detection, genetic, and codon usage bias analyses of the VP2 gene of mink bocavirus. 61
32020392 2020
32
Probiotics, including nisin-based probiotics, improve clinical and microbial outcomes relevant to oral and systemic diseases. 61
31850634 2020
33
The "streamline phenomenon" of the portal vein flow and its influence on liver involvement by gastrointestinal diseases: current concepts and imaging-based review. 61
31768597 2020
34
Circulating concentration of interleukin-37 in Helicobacter pylori-infected patients with peptic ulcer: Its association with IL-37 related gene polymorphisms and bacterial virulence factor CagA. 61
31751903 2020
35
Cellular evasion strategies of Helicobacter pylori in regulating its intracellular fate. 61
32033828 2020
36
Development of a novel oral delivery vehicle for probiotics. 61
32039674 2020
37
Moslea Herba flavonoids alleviated influenza A virus-induced pulmonary endothelial barrier disruption via suppressing NOX4/NF-κB/MLCK pathway. 61
32017949 2020
38
Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects. 61
31877495 2020
39
Profile analysis reveals endogenous RNAs regulate necrotizing enterocolitis progression. 61
32036223 2020
40
The Role of Gastrointestinal-Related Fatty Acid-Binding Proteins as Biomarkers in Gastrointestinal Diseases. 61
31529416 2020
41
Impact of Endometriosis Diagnostic Delays on Healthcare Resource Utilization and Costs. 61
31960340 2020
42
Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland - is there potential to extend veterinary options to reduce antimicrobial use? 61
31465817 2020
43
Review article: bacteriophages in gastroenterology-from biology to clinical applications. 61
31696976 2020
44
Water safety plans and risk assessment: A novel procedure applied to treated water turbidity and gastrointestinal diseases. 61
31523016 2020
45
Medicinal plants for gastrointestinal diseases among the Kuki-Chin ethnolinguistic groups across Bangladesh, India, and Myanmar: A comparative and network analysis study. 61
31917280 2020
46
Amyloid-Polyphenol Hybrid Nanofilaments Mitigate Colitis and Regulate Gut Microbial Dysbiosis. 61
31961657 2020
47
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Variations for Gastrointestinal System Disease

Expression for Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for Gastrointestinal System Disease

Pathways related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 MIR31 MIR21 MIR199A1 MIR17 MIR145 MIR143
2 10.27 MIR199A1 MIR145
3 9.8 GAST CCK

GO Terms for Gastrointestinal System Disease

Cellular components related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 SERPINA3 S100A8 MIR31 MIR21 MIR199A1 MIR17

Biological processes related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.78 MIR126 MIR143 MIR199A1 MIR21
2 positive regulation of inflammatory response GO:0050729 9.73 MIR126 MIR21 S100A8
3 positive regulation of blood vessel endothelial cell migration GO:0043536 9.63 MIR126 MIR143 MIR31
4 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.57 MIR17 MIR199A1
5 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.55 MIR17 MIR199A1
6 leukocyte migration involved in inflammatory response GO:0002523 9.54 CCR6 S100A8
7 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.54 MIR145 MIR199A1 MIR21
8 angiotensin-activated signaling pathway GO:0038166 9.52 MIR143 MIR145
9 positive regulation of metalloendopeptidase activity GO:1904685 9.51 MIR17 MIR21
10 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.49 MIR17 MIR21
11 miRNA mediated inhibition of translation GO:0035278 9.46 MIR145 MIR17 MIR21 MIR31
12 aorta smooth muscle tissue morphogenesis GO:0060414 9.43 MIR143 MIR145
13 regulation of phenotypic switching GO:1900239 9.4 MIR143 MIR145
14 positive regulation of angiogenesis GO:0045766 9.35 MIR126 MIR143 MIR199A1 MIR21 MIR31
15 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.32 MIR143 MIR17
16 gene silencing by miRNA GO:0035195 9.28 MIR126 MIR143 MIR145 MIR17 MIR196A1 MIR199A1
17 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.26 MIR143 MIR145

Molecular functions related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.28 MIR518A1 MIR31 MIR21 MIR199A1 MIR196A1 MIR17

Sources for Gastrointestinal System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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