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MCID: GST051
MIFTS: 38

Gastrointestinal Tuberculosis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Gastrointestinal Tuberculosis

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MalaCards integrated aliases for Gastrointestinal Tuberculosis:

Name: Gastrointestinal Tuberculosis 12 15 17
Tuberculosis of Intestines, Peritoneum and Mesenteric Glands 12 32
Tuberculosis, Gastrointestinal 43 71
Tuberculosis of Intestines, Peritoneum, and Mesenteric Glands 12
Tuberculosis of Gastrointestinal Tract 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:404
MeSH 43 D014385
ICD10 32 A18.3
UMLS 71 C0041312
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Summaries for Gastrointestinal Tuberculosis

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Disease Ontology : 12 An abdominal tuberculosis that results in infection located in gastrointestinal tract. The infection has symptom abdominal pain, has symptom weight loss, has symptom fever, has symptom anorexia, has symptom change in bowel habits, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tuberculosis, also known as tuberculosis of intestines, peritoneum and mesenteric glands, is related to hepatic tuberculosis and oral tuberculosis, and has symptoms including vomiting, fever and abdominal pain. An important gene associated with Gastrointestinal Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are T cell receptor signaling pathway and Th17 cell differentiation. Affiliated tissues include gastrointestinal tract, colon and liver.

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Related Diseases for Gastrointestinal Tuberculosis

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Diseases related to Gastrointestinal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
# Related Disease Score Top Affiliating Genes
1 hepatic tuberculosis 32.1 GPT ALB
2 oral tuberculosis 32.0 TNF IFNG CD4
3 intestinal tuberculosis 30.4 TNF OR2H2 NOD2 IFNG CRP CD4
4 tuberculous peritonitis 30.4 TBP IFNG CRPPA CRP CEACAM5 ALB
5 pulmonary tuberculosis 30.0 TNF IFNG CRP ALB ADA
6 ileus 30.0 TNF IFNG CRP
7 mycobacterium tuberculosis 1 30.0 TNF NOD2 IFNG CRP CD4 ADA
8 invasive aspergillosis 29.8 NOD2 IFNG CD4
9 appendicitis 29.7 TNF IFNG CRP ALB
10 crohn's colitis 29.7 TNF NOD2 IFNG
11 aspergillosis 29.6 TNF NOD2 IFNG
12 intestinal perforation 29.6 NOD2 GPT CRP ALB
13 peritonitis 29.5 TNF IFNG CRP ALB ADA
14 crohn's disease 29.4 TNF NOD2 IFNG CRP CD4 ALB
15 vaginal discharge 29.3 CRP CEACAM5 CD40LG CD4
16 ulcerative colitis 29.3 TNF NOD2 IFNG CRP
17 toxic shock syndrome 29.2 TNF IFNG CRP CD40LG
18 amyloidosis 29.2 TNF CRP CD40LG ALB
19 histoplasmosis 29.2 TNF IFNG CD40LG CD4
20 intestinal obstruction 29.1 NOD2 GPT CRP CEACAM5 ALB
21 dysentery 28.9 TNF CRP CD40LG CD4 ALB
22 inflammatory bowel disease 28.9 TNF NOD2 IFNG CRP CD40LG ALB
23 extrapulmonary tuberculosis 28.8 TNF TBP IFNG CRP CD4 ALB
24 diarrhea 28.5 TNF IFNG GPT CD40LG ALB
25 bacterial infectious disease 28.4 TNF NOD2 IFNG CRP CD40LG CD4
26 miliary tuberculosis 28.3 TNF IFNG CRP CD40LG CD4 ALB
27 cecal disease 28.2 TNF GPT CRP CEACAM5 CD40LG ALB
28 abdominal tuberculosis 26.9 TNF TBP OR2H2 NOD2 IFNG CRP
29 esophageal tuberculosis 11.2
30 chronic duodenal ileus 10.5 CRP ALB
31 yellow nail syndrome 10.5 ALB ADA
32 necrotizing gastritis 10.5 CRP ALB
33 peptic ulcer perforation 10.5 CRP ALB
34 critical illness polyneuropathy 10.4 CRP ALB
35 skeletal tuberculosis 10.4 IFNG CRP
36 epidural abscess 10.4 CRP ALB
37 external ear carcinoma 10.4 CRP CEACAM5
38 pleural lipoma 10.4 CEACAM5 ADA
39 panophthalmitis 10.4 IFNG CD4
40 central nervous system tuberculosis 10.4 CD4 ADA
41 breast abscess 10.4 CRP CD4
42 pyomyositis 10.4 CRP CD4
43 secondary hemophagocytic lymphohistiocytosis 10.4 TNF ADA
44 generalized atherosclerosis 10.4 CRP ALB
45 guttate psoriasis 10.4 NOD2 IFNG
46 duodenal obstruction 10.4 CEACAM5 ALB
47 aspiration pneumonitis 10.4 CRP ALB
48 acute orbital inflammation 10.4 CRP CD4
49 klebsiella pneumonia 10.4 CRP ALB
50 nickel allergic contact dermatitis 10.4 IFNG CD4

Graphical network of the top 20 diseases related to Gastrointestinal Tuberculosis:



Diseases related to Gastrointestinal Tuberculosis
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Symptoms & Phenotypes for Gastrointestinal Tuberculosis

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Symptoms:

12
  • • vomiting
  • • fever
  • • abdominal pain
  • • weight loss
  • • anorexia
  • • nausea
  • • change in bowel habits
Sources

Drugs & Therapeutics for Gastrointestinal Tuberculosis

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Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tuberculosis

Cochrane evidence based reviews: tuberculosis, gastrointestinal

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Genetic Tests for Gastrointestinal Tuberculosis

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Anatomical Context for Gastrointestinal Tuberculosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal Tuberculosis:

19
Gastrointestinal Tract

MalaCards organs/tissues related to Gastrointestinal Tuberculosis:

40
Colon, Liver, Lung, Bone, Lymph Node, Skin, Heart
Sources

Publications for Gastrointestinal Tuberculosis

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Articles related to Gastrointestinal Tuberculosis:

(show top 50) (show all 162)
# Title Authors PMID Year
1
Tuberculosis and Melioidosis at Distinct Sites Occurring Simultaneously. 61
31984142 2020
2
Vulvar lymphangiectasia secondary to gastrointestinal tuberculosis infection in a teenager. 61
31618790 2020
3
A case of gastrointestinal tuberculosis with unusual manifestations of carcinomatosis. 61
31893062 2019
4
Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study. 61
31758440 2019
5
Gastric tuberculosis presenting as non healing ulcer: A case report. 61
31813440 2019
6
Massive infected ascites in an immunocompetent patient with gastrointestinal tuberculosis. 61
31451473 2019
7
Duodenal tuberculosis; uncommon cause of gastric outlet obstruction. 61
31228078 2019
8
Atypical serious hematochezia and rare imaging feature in gastrointestinal tuberculosis. 61
30232704 2019
9
Multiplex Polymerase Chain Reaction for diagnosis of gastrointestinal tuberculosis. 61
30834338 2019
10
Diagnosis of abdominal tuberculosis: lessons learned over 30 years: pectoral assay. 61
31338118 2019
11
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 61
30587190 2018
12
Gastric Tuberculosis Presenting as a Subepithelial Mass: A Rare Cause of Gastrointestinal Bleeding. 61
30642149 2018
13
Primary Appendicular Malignancy Presenting as Abdominal Wall Abscess with Secondary Tuberculosis Infection: an Interesting Case Report. 61
30538401 2018
14
Anorectal tuberculosis as a chronic rectal mass mimicking rectal prolapse in a child-a case report. 61
30568795 2018
15
Acquired zinc deficiency in a renal transplant recipient with gastrointestinal tuberculosis responding promptly to oral correction. 61
30381519 2018
16
Gastrointestinal Tuberculosis Presenting as Malnutrition and Distal Colonic Bowel Obstruction. 61
29682364 2018
17
Tuberculous Enteritis Presenting as Acute Appendicitis and Perirectal Abscess. 61
29560012 2018
18
Clinical and laboratory features of intestinal tuberculosis. 61
29559804 2018
19
[Gastric tuberculosis in an elderly patient:a case report]. 61
30416160 2018
20
Perforated tuberculous appendicitis: a rare case report. 61
29881313 2018
21
Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation. 61
29179699 2017
22
A Rare Thermophilic Bug in Complicated Diverticular Abscess. 61
29118685 2017
23
[Gastrointestinal tuberculosis as a cause of massive gastrointestinal bleeding in a patient with HIV infection]. 61
29165521 2017
24
Gastric outlet obstruction: an unusual case of primary duodenal tuberculosis. 61
28343151 2017
25
Kaleidoscopic View of Bowel Tuberculosis on Multi- Detector Computed Tomography (CT) Enterography - A Novel Technique Unfolding an Archaic Disease. 61
29657645 2017
26
Ileocaecal and transverse colonic tuberculosis mimicking colonic malignancy - A case report. 61
28486175 2017
27
The HIV manifestations within the gastrointestinal tract: A pictorial review. 61
31754480 2017
28
Gastrointestinal Tuberculosis. 61
28084201 2016
29
Clinico-Pathological Profile and Surgical Outcome of Patients of Gastrointestinal Tuberculosis Undergoing Laparotomy. 61
28044950 2016
30
A retrospective cohort study of 756 cases of abdominal tuberculosis: Two decades single centre experience. 61
27998497 2016
31
Role of mitochondrial oxidative stress on lymphocyte homeostasis in patients diagnosed with extra-pulmonary tuberculosis. 61
26431927 2016
32
The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review. 61
27123348 2016
33
[Asymptomatic Synchronous Tuberculosis Involving Stomach and Small Bowel in Immunocompetent Patient]. 61
26691192 2015
34
Intermittent Directly Observed Therapy for Abdominal Tuberculosis: A Multicenter Randomized Controlled Trial Comparing 6 Months Versus 9 Months of Therapy. 61
25969531 2015
35
Management of Severe Gastrointestinal Tuberculosis with Injectable Antituberculous Drugs. 61
26543395 2015
36
Intestinal Flora Modification of Arthritis Pattern in Spondyloarthropathy. 61
26267718 2015
37
Radiological findings in duodenal tuberculosis: a 15-year experience. 61
25416003 2015
38
Abdominal tuberculosis mimicking Crohn's disease's exacerbation: A clinical, diagnostic and surgical dilemma. A case report. 61
25528041 2015
39
Non-healing gastro-duodenal ulcer: A rare presentation of primary abdominal tuberculosis. 61
25506841 2015
40
Tuberculosis infection causing intestinal perforations in 2 patients with systemic lupus erythematosus. 61
25036568 2014
41
Tubercular duodenal, jejunal and ileocecal stricture in a patient. 61
24334467 2013
42
Esophageal tuberculosis presenting with hematemesis. 61
24255751 2013
43
Development of miliary tuberculosis under infliximab in a patient with spondyloarthritis and suspected Crohn's disease. 61
24122379 2013
44
Multiplex PCR for rapid diagnosis of gastrointestinal tuberculosis. 61
23853431 2013
45
Primary duodenal tuberculosis presenting as gastric-outlet obstruction: Its diagnosis. 61
23860052 2013
46
Gastrointestinal tuberculosis is not associated with proton pump inhibitors: a retrospective cohort study. 61
23345949 2013
47
A case series of gastrointestinal tuberculosis in renal transplant patients. 61
24558621 2013
48
[Gastrointestinal tuberculosis: a deceptive disease]. 61
23739601 2013
49
Primary tuberculous appendicitis presented with caecal perforation: a case report. 61
23043927 2012
50
Duodenal tuberculosis presenting as gatric outlet obstruction. 61
24960738 2012
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Variations for Gastrointestinal Tuberculosis

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Expression for Gastrointestinal Tuberculosis

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Search GEO for disease gene expression data for Gastrointestinal Tuberculosis.
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Pathways for Gastrointestinal Tuberculosis

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Pathways related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
T cell receptor signaling pathway 36
Show member pathways
 12.37 TNF IFNG CD40LG CD4
2
Th17 cell differentiation 36
Show member pathways
 12.35 TNF NOD2 IFNG CD4
3
NF-kappaB Signaling 4
12.31 TNF IFNG CEACAM5 CD40LG
4
4-1BB Pathway 63
Show member pathways
 12.15 TNF TBP IFNG CD40LG CD4
5
Folate Metabolism 1
Show member pathways
 12 TNF IFNG CRP ALB
6
Innate Lymphoid Cell Differentiation Pathways 64
11.56 TNF IFNG CD4
7
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.51 TNF IFNG CD40LG
8
Dendritic Cells Developmental Lineage Pathway 64
11.48 TNF IFNG CD4
9
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.38 TNF IFNG CD40LG
10
Malaria 36
11.2 TNF IFNG CD40LG
11
Primary immunodeficiency 36
11.01 CD40LG CD4 ADA
12
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
10.99 TNF IFNG CEACAM5 CD4
13
Cytokines and Inflammatory Response 1
10.59 TNF IFNG CD4
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GO Terms for Gastrointestinal Tuberculosis

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Cellular components related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TNF IFNG GPT CRP CD40LG ALB
2 external side of plasma membrane GO:0009897 9.46 TNF CD40LG CD4 ADA
3 cell surface GO:0009986 9.1 TNF NOD2 CEACAM5 CD40LG CD4 ADA

Biological processes related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 astrocyte activation GO:0048143 9.51 IFNG TNF
2 positive regulation of calcium-mediated signaling GO:0050850 9.49 ADA CD4
3 positive regulation of amyloid-beta formation GO:1902004 9.48 IFNG TNF
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IFNG TNF
5 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.43 IFNG NOD2
6 positive regulation of chemokine biosynthetic process GO:0045080 9.4 IFNG TNF
7 negative regulation of amyloid-beta clearance GO:1900222 9.37 IFNG TNF
8 negative regulation of lipid storage GO:0010888 9.32 CRP TNF
9 regulation of immunoglobulin secretion GO:0051023 9.26 CD40LG TNF
10 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG TNF
11 positive regulation of nitrogen compound metabolic process GO:0051173 8.96 IFNG TNF
12 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF
Sources

Sources for Gastrointestinal Tuberculosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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