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MCID: GST051
MIFTS: 38

Gastrointestinal Tuberculosis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Gastrointestinal Tuberculosis

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MalaCards integrated aliases for Gastrointestinal Tuberculosis:

Name: Gastrointestinal Tuberculosis 12 15 17
Tuberculosis of Intestines, Peritoneum and Mesenteric Glands 12 32
Tuberculosis, Gastrointestinal 43 71
Tuberculosis of Intestines, Peritoneum, and Mesenteric Glands 12
Tuberculosis of Gastrointestinal Tract 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:404
MeSH 43 D014385
SNOMED-CT 67 240376003
ICD10 32 A18.3
UMLS 71 C0041312
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Summaries for Gastrointestinal Tuberculosis

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Disease Ontology : 12 An abdominal tuberculosis that results in infection located in gastrointestinal tract. The infection has symptom abdominal pain, has symptom weight loss, has symptom fever, has symptom anorexia, has symptom change in bowel habits, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tuberculosis, also known as tuberculosis of intestines, peritoneum and mesenteric glands, is related to oral tuberculosis and tuberculous peritonitis, and has symptoms including vomiting, fever and weight loss. An important gene associated with Gastrointestinal Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are T cell receptor signaling pathway and Th17 cell differentiation. Affiliated tissues include gastrointestinal tract, colon and lymph node, and related phenotype is immune system.

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Related Diseases for Gastrointestinal Tuberculosis

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Diseases related to Gastrointestinal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 564)
# Related Disease Score Top Affiliating Genes
1 oral tuberculosis 31.8 TNF IFNG CRP CD4
2 tuberculous peritonitis 31.3 TBP IFNG CRP CEACAM5 ALB ADA
3 pulmonary tuberculosis 30.1 TNF IFNG CRP ALB ADA
4 ileus 30.0 TNF IFNG CRP
5 mycobacterium tuberculosis 1 29.9 TNF NOD2 IFNG CRP CD4 ADA
6 appendicitis 29.8 TNF IFNG CRP ALB
7 invasive aspergillosis 29.6 NOD2 IFNG CD4
8 crohn's colitis 29.6 TNF NOD2 IFNG
9 peritonitis 29.6 TNF IFNG CRP ALB ADA
10 aspergillosis 29.6 TNF NOD2 IFNG
11 ileitis 29.5 TNF NOD2 CD4
12 intestinal perforation 29.3 TNF NOD2 CRP CD4 ALB
13 crohn's disease 29.3 TNF NOD2 IFNG CRP CD4 ALB
14 ulcerative colitis 29.2 TNF NOD2 IFNG CRP
15 toxic shock syndrome 29.2 TNF IFNG CRP CD40LG
16 amyloidosis 29.2 TNF CRP CD40LG ALB
17 histoplasmosis 29.1 TNF IFNG CD40LG CD4
18 intestinal obstruction 29.1 TNF NOD2 CRP CEACAM5 ALB
19 intestinal tuberculosis 29.0 TNF OR2H2 NOD2 MIR4659A IFNG GP2
20 intestinal disease 28.9 TNF NOD2 CRP CD4 ALB
21 extrapulmonary tuberculosis 28.9 TNF TBP IFNG CRP CD4 ALB
22 dysentery 28.9 TNF CRP CD40LG CD4 ALB
23 vaginal discharge 28.7 TNF CRP CEACAM5 CD40LG CD4
24 inflammatory bowel disease 28.7 TNF NOD2 IFNG CRP CD40LG ALB
25 diarrhea 28.6 TNF NOD2 IFNG CD40LG ALB
26 cecal disease 28.4 TNF CRP CEACAM5 CD40LG CD4 ALB
27 miliary tuberculosis 28.2 TNF IFNG CRP CD40LG CD4 ALB
28 abdominal tuberculosis 26.8 TNF TBP OR2H2 MIR4659A IFNG CRP
29 hepatic tuberculosis 11.2
30 esophageal tuberculosis 11.2
31 tuberculous empyema 10.5 TBP ADA
32 chronic duodenal ileus 10.5 CRP ALB
33 yellow nail syndrome 10.5 ALB ADA
34 peptic ulcer perforation 10.5 CRP ALB
35 secondary hemophagocytic lymphohistiocytosis 10.5 TNF ADA
36 ascending cholangitis 10.4 CRP ALB
37 ankylosing spondylitis 1 10.4 CRP ALB
38 petrositis 10.4 IFNG CRP
39 critical illness polyneuropathy 10.4 CRP ALB
40 epidural abscess 10.4 CRP ALB
41 skeletal tuberculosis 10.4 IFNG CRP
42 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
43 ankylosing spondylitis 3 10.4 CRP ALB
44 ocular tuberculosis 10.4 IFNG CD4
45 listeria meningitis 10.4 TNF ADA
46 panophthalmitis 10.4 IFNG CD4
47 staphylococcal toxic shock syndrome 10.4 TNF IFNG
48 autoimmune myocarditis 10.4 TNF IFNG
49 spotted fever rickettsiosis 10.4 TNF IFNG
50 posterior scleritis 10.4 TNF CRP

Graphical network of the top 20 diseases related to Gastrointestinal Tuberculosis:



Diseases related to Gastrointestinal Tuberculosis
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Symptoms & Phenotypes for Gastrointestinal Tuberculosis

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Symptoms:

12
  • • vomiting
  • • fever
  • • weight loss
  • • abdominal pain
  • • anorexia
  • • nausea
  • • change in bowel habits

MGI Mouse Phenotypes related to Gastrointestinal Tuberculosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ADA ALB CD4 CD40LG CRP IFNG
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Drugs & Therapeutics for Gastrointestinal Tuberculosis

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Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tuberculosis

Cochrane evidence based reviews: tuberculosis, gastrointestinal

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Genetic Tests for Gastrointestinal Tuberculosis

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Anatomical Context for Gastrointestinal Tuberculosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal Tuberculosis:

19
Gastrointestinal Tract

MalaCards organs/tissues related to Gastrointestinal Tuberculosis:

40
Colon, Lymph Node, Testes
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Publications for Gastrointestinal Tuberculosis

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Articles related to Gastrointestinal Tuberculosis:

(show top 50) (show all 164)
# Title Authors PMID Year
1
Challenging diagnosis of gastrointestinal tuberculosis made simpler with multi-targeted loop-mediated isothermal amplification assay. 61
32433424 2020
2
Duodenal tuberculosis; uncommon cause of gastric outlet obstruction. 61
31228078 2020
3
How can gastro-intestinal tuberculosis diagnosis be improved? A prospective cohort study. 61
32228479 2020
4
Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study. 61
31758440 2020
5
Vulvar lymphangiectasia secondary to gastrointestinal tuberculosis infection in a teenager. 61
31618790 2020
6
Tuberculosis and Melioidosis at Distinct Sites Occurring Simultaneously. 61
31984142 2020
7
A case of gastrointestinal tuberculosis with unusual manifestations of carcinomatosis. 61
31893062 2019
8
Gastric tuberculosis presenting as non healing ulcer: A case report. 61
31813440 2019
9
Massive infected ascites in an immunocompetent patient with gastrointestinal tuberculosis. 61
31451473 2019
10
Atypical serious hematochezia and rare imaging feature in gastrointestinal tuberculosis. 61
30232704 2019
11
Multiplex Polymerase Chain Reaction for diagnosis of gastrointestinal tuberculosis. 61
30834338 2019
12
Diagnosis of abdominal tuberculosis: lessons learned over 30 years: pectoral assay. 61
31338118 2019
13
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 61
30587190 2018
14
Gastric Tuberculosis Presenting as a Subepithelial Mass: A Rare Cause of Gastrointestinal Bleeding. 61
30642149 2018
15
Primary Appendicular Malignancy Presenting as Abdominal Wall Abscess with Secondary Tuberculosis Infection: an Interesting Case Report. 61
30538401 2018
16
Anorectal tuberculosis as a chronic rectal mass mimicking rectal prolapse in a child-a case report. 61
30568795 2018
17
Acquired zinc deficiency in a renal transplant recipient with gastrointestinal tuberculosis responding promptly to oral correction. 61
30381519 2018
18
Gastrointestinal Tuberculosis Presenting as Malnutrition and Distal Colonic Bowel Obstruction. 61
29682364 2018
19
Tuberculous Enteritis Presenting as Acute Appendicitis and Perirectal Abscess. 61
29560012 2018
20
Clinical and laboratory features of intestinal tuberculosis. 61
29559804 2018
21
[Gastric tuberculosis in an elderly patient:a case report]. 61
30416160 2018
22
Perforated tuberculous appendicitis: a rare case report. 61
29881313 2018
23
Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation. 61
29179699 2017
24
A Rare Thermophilic Bug in Complicated Diverticular Abscess. 61
29118685 2017
25
[Gastrointestinal tuberculosis as a cause of massive gastrointestinal bleeding in a patient with HIV infection]. 61
29165521 2017
26
Gastric outlet obstruction: an unusual case of primary duodenal tuberculosis. 61
28343151 2017
27
Ileocaecal and transverse colonic tuberculosis mimicking colonic malignancy - A case report. 61
28486175 2017
28
Kaleidoscopic View of Bowel Tuberculosis on Multi- Detector Computed Tomography (CT) Enterography - A Novel Technique Unfolding an Archaic Disease. 61
29657645 2017
29
The HIV manifestations within the gastrointestinal tract: A pictorial review. 61
31754480 2017
30
Gastrointestinal Tuberculosis. 61
28084201 2016
31
Clinico-Pathological Profile and Surgical Outcome of Patients of Gastrointestinal Tuberculosis Undergoing Laparotomy. 61
28044950 2016
32
A retrospective cohort study of 756 cases of abdominal tuberculosis: Two decades single centre experience. 61
27998497 2016
33
Role of mitochondrial oxidative stress on lymphocyte homeostasis in patients diagnosed with extra-pulmonary tuberculosis. 61
26431927 2016
34
The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review. 61
27123348 2016
35
[Asymptomatic Synchronous Tuberculosis Involving Stomach and Small Bowel in Immunocompetent Patient]. 61
26691192 2015
36
Intermittent Directly Observed Therapy for Abdominal Tuberculosis: A Multicenter Randomized Controlled Trial Comparing 6 Months Versus 9 Months of Therapy. 61
25969531 2015
37
Management of Severe Gastrointestinal Tuberculosis with Injectable Antituberculous Drugs. 61
26543395 2015
38
Intestinal Flora Modification of Arthritis Pattern in Spondyloarthropathy. 61
26267718 2015
39
Radiological findings in duodenal tuberculosis: a 15-year experience. 61
25416003 2015
40
Abdominal tuberculosis mimicking Crohn's disease's exacerbation: A clinical, diagnostic and surgical dilemma. A case report. 61
25528041 2015
41
Non-healing gastro-duodenal ulcer: A rare presentation of primary abdominal tuberculosis. 61
25506841 2015
42
Tuberculosis infection causing intestinal perforations in 2 patients with systemic lupus erythematosus. 61
25036568 2014
43
Tubercular duodenal, jejunal and ileocecal stricture in a patient. 61
24334467 2013
44
Esophageal tuberculosis presenting with hematemesis. 61
24255751 2013
45
Development of miliary tuberculosis under infliximab in a patient with spondyloarthritis and suspected Crohn's disease. 61
24122379 2013
46
Multiplex PCR for rapid diagnosis of gastrointestinal tuberculosis. 61
23853431 2013
47
Primary duodenal tuberculosis presenting as gastric-outlet obstruction: Its diagnosis. 61
23860052 2013
48
Gastrointestinal tuberculosis is not associated with proton pump inhibitors: a retrospective cohort study. 61
23345949 2013
49
A case series of gastrointestinal tuberculosis in renal transplant patients. 61
24558621 2013
50
[Gastrointestinal tuberculosis: a deceptive disease]. 61
23739601 2013
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Variations for Gastrointestinal Tuberculosis

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Expression for Gastrointestinal Tuberculosis

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Search GEO for disease gene expression data for Gastrointestinal Tuberculosis.
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Pathways for Gastrointestinal Tuberculosis

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Pathways related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
T cell receptor signaling pathway 36
Show member pathways
 12.38 TNF IFNG CD40LG CD4
2
Th17 cell differentiation 36
Show member pathways
 12.36 TNF NOD2 IFNG CD4
3
NF-kappaB Signaling 4
12.31 TNF IFNG CEACAM5 CD40LG
4
4-1BB Pathway 63
Show member pathways
 12.15 TNF TBP IFNG CD40LG CD4
5
Folate Metabolism 1
Show member pathways
 12 TNF IFNG CRP ALB
6
IL27-mediated signaling events 1
Show member pathways
 11.71 TNF IFNG CD4
7
Innate Lymphoid Cells Differentiation 64
11.56 TNF IFNG CD4
8
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.51 TNF IFNG CD40LG
9
Dendritic Cells Developmental Lineage Pathway 64
11.48 TNF IFNG CD4
10
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.38 TNF IFNG CD40LG
11
Malaria 36
11.2 TNF IFNG CD40LG
12
Primary immunodeficiency 36
11.01 CD40LG CD4 ADA
13
Hematopoietic Stem Cells and Lineage-specific Markers 64
10.99 TNF IFNG CEACAM5 CD4
14
Cytokines and Inflammatory Response 1
10.59 TNF IFNG CD4
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GO Terms for Gastrointestinal Tuberculosis

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Cellular components related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TNF IFNG GP2 CRP CD40LG ALB
2 cell surface GO:0009986 9.17 TNF NOD2 GP2 CEACAM5 CD40LG CD4

Biological processes related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 embryonic digestive tract development GO:0048566 9.52 TNF ADA
2 positive regulation of calcium-mediated signaling GO:0050850 9.51 CD4 ADA
3 astrocyte activation GO:0048143 9.49 TNF IFNG
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.48 TNF IFNG
5 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.46 NOD2 IFNG
6 positive regulation of chemokine biosynthetic process GO:0045080 9.43 TNF IFNG
7 negative regulation of amyloid-beta clearance GO:1900222 9.4 TNF IFNG
8 negative regulation of lipid storage GO:0010888 9.37 TNF CRP
9 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.32 TNF IFNG
10 regulation of immunoglobulin secretion GO:0051023 9.26 TNF CD40LG
11 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
12 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
13 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Molecular functions related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.92 TBP NOD2 CUTA CD4
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Sources for Gastrointestinal Tuberculosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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