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MCID: GST051
MIFTS: 36

Gastrointestinal Tuberculosis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Gastrointestinal Tuberculosis

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MalaCards integrated aliases for Gastrointestinal Tuberculosis:

Name: Gastrointestinal Tuberculosis 12 15 17
Tuberculosis of Intestines, Peritoneum and Mesenteric Glands 12 32
Tuberculosis, Gastrointestinal 44 70
Tuberculosis of Intestines, Peritoneum, and Mesenteric Glands 12
Tuberculosis of Gastrointestinal Tract 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:404
MeSH 44 D014385
SNOMED-CT 67 154286002
ICD10 32 A18.3
UMLS 70 C0041312
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Summaries for Gastrointestinal Tuberculosis

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Disease Ontology : 12 An abdominal tuberculosis that results in infection located in gastrointestinal tract. The infection has symptom abdominal pain, has symptom weight loss, has symptom fever, has symptom anorexia, has symptom change in bowel habits, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tuberculosis, also known as tuberculosis of intestines, peritoneum and mesenteric glands, is related to oral tuberculosis and tuberculous peritonitis, and has symptoms including vomiting, fever and abdominal pain. An important gene associated with Gastrointestinal Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are 4-1BB Pathway and Th17 cell differentiation. Affiliated tissues include gastrointestinal tract and colon.

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Related Diseases for Gastrointestinal Tuberculosis

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Diseases related to Gastrointestinal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 553)
# Related Disease Score Top Affiliating Genes
1 oral tuberculosis 31.4 TNF IFNG CRP CD4
2 tuberculous peritonitis 31.0 TBP IFNG CRP CEACAM5 ALB ADA
3 hepatic tuberculosis 30.7 IFNG GPT CRP CEACAM5 CD4 ALB
4 pulmonary tuberculosis 30.3 TNF IFNG ALB ADA
5 extrapulmonary tuberculosis 30.2 IFNG CRP ADA
6 mycobacterium tuberculosis 1 30.1 TNF NOD2 IFNG CD4 ADA
7 peritonitis 29.9 TNF CRP ALB ADA
8 appendicitis 29.9 TNF IFNG CRP ALB
9 toxic shock syndrome 29.8 TNF IFNG CRP
10 crohn's colitis 29.6 TNF NOD2 IFNG
11 aspergillosis 29.5 TNF NOD2 IFNG
12 intestinal tuberculosis 29.4 TNF NOD2 MIR4659A IFNG GP2 CUTA
13 crohn's disease 29.4 TNF NOD2 IFNG CRP CD4 ALB
14 colitis 29.3 TNF NOD2 IFNG CD4
15 vaginal discharge 29.2 TNF CRP CEACAM5 CD4 ALB
16 dysentery 29.2 TNF GPT CRP CD4 ALB
17 miliary tuberculosis 29.1 TNF IFNG CRP CD4 ALB ADA
18 intestinal perforation 29.0 TNF NOD2 GPT CRP CD4 ALB
19 liver cirrhosis 29.0 TNF IFNG GPT CRP ALB ADA
20 diarrhea 28.9 TNF NOD2 IFNG GPT ALB
21 intestinal obstruction 28.8 TNF NOD2 GPT CRP CEACAM5 ALB
22 abdominal tuberculosis 28.1 TNF TBP MIR4659A IFNG GPT CRP
23 esophageal tuberculosis 11.0
24 tuberculous empyema 10.4 TBP ADA
25 chronic duodenal ileus 10.4 CRP ALB
26 yellow nail syndrome 10.4 ALB ADA
27 peptic ulcer perforation 10.3 CRP ALB
28 ankylosing spondylitis 3 10.3 CRP ALB
29 petrositis 10.3 IFNG CRP
30 chronic intestinal vascular insufficiency 10.3 CRP ALB
31 cork-handlers' disease 10.3 CD4 ALB
32 riedel's fibrosing thyroiditis 10.3 CD4 ALB
33 secondary hemophagocytic lymphohistiocytosis 10.3 TNF ADA
34 necrotic uveal melanoma 10.3 IFNG CD4
35 generalized atherosclerosis 10.3 CRP ALB
36 benign essential hypertension 10.3 CRP ALB
37 intracranial embolism 10.3 CRP ALB
38 drug reaction with eosinophilia and systemic symptoms 10.3 TNF CRP
39 listeria meningitis 10.3 TNF ADA
40 active peptic ulcer disease 10.3 CRP ALB
41 primary syphilis 10.3 CRP CD4
42 urogenital tuberculosis 10.3 CRP CD4
43 ocular tuberculosis 10.3 IFNG CD4
44 breast abscess 10.3 CRP CD4
45 anterior scleritis 10.3 TNF CRP
46 hypertensive retinopathy 10.3 CRP ALB
47 pyomyositis 10.3 CRP CD4
48 meckel diverticulum 10.3 CRP ALB
49 orbital cellulitis 10.3 CRP CD4
50 acute orbital inflammation 10.3 CRP CD4

Graphical network of the top 20 diseases related to Gastrointestinal Tuberculosis:



Diseases related to Gastrointestinal Tuberculosis
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Symptoms & Phenotypes for Gastrointestinal Tuberculosis

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Symptoms:

12
  • • vomiting
  • • fever
  • • abdominal pain
  • • anorexia
  • • weight loss
  • • nausea
  • • change in bowel habits
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Drugs & Therapeutics for Gastrointestinal Tuberculosis

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Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tuberculosis

Cochrane evidence based reviews: tuberculosis, gastrointestinal

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Genetic Tests for Gastrointestinal Tuberculosis

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Anatomical Context for Gastrointestinal Tuberculosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal Tuberculosis:

19
Gastrointestinal Tract

MalaCards organs/tissues related to Gastrointestinal Tuberculosis:

40
Colon
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Publications for Gastrointestinal Tuberculosis

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Articles related to Gastrointestinal Tuberculosis:

(show top 50) (show all 170)
# Title Authors PMID Year
1
Management of gastrointestinal tuberculosis during COVID pandemic: Lessons for posterity. 61
33323345 2021
2
Gastric tuberculosis masquerading as advanced malignancy in a young male. 61
33323665 2020
3
Gastrointestinal tuberculosis, the great simulator. From inflammatory disease to a tumor. 61
32755148 2020
4
Challenging diagnosis of gastrointestinal tuberculosis made simpler with multi-targeted loop-mediated isothermal amplification assay. 61
32433424 2020
5
Gastrointestinal Tuberculosis Mimicking Crohn's Disease. 61
32775550 2020
6
[Acute perforated appendicitis secondary to tuberculosis as a cause of postpartum infection]. 61
32730488 2020
7
Duodenal tuberculosis; uncommon cause of gastric outlet obstruction. 61
31228078 2020
8
Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study. 61
31758440 2020
9
How can gastro-intestinal tuberculosis diagnosis be improved? A prospective cohort study. 61
32228479 2020
10
Vulvar lymphangiectasia secondary to gastrointestinal tuberculosis infection in a teenager. 61
31618790 2020
11
Tuberculosis and Melioidosis at Distinct Sites Occurring Simultaneously. 61
31984142 2020
12
A case of gastrointestinal tuberculosis with unusual manifestations of carcinomatosis. 61
31893062 2019
13
Gastric tuberculosis presenting as non healing ulcer: A case report. 61
31813440 2019
14
Massive infected ascites in an immunocompetent patient with gastrointestinal tuberculosis. 61
31451473 2019
15
Atypical serious hematochezia and rare imaging feature in gastrointestinal tuberculosis. 61
30232704 2019
16
Multiplex Polymerase Chain Reaction for diagnosis of gastrointestinal tuberculosis. 61
30834338 2019
17
Diagnosis of abdominal tuberculosis: lessons learned over 30 years: pectoral assay. 61
31338118 2019
18
Anorectal tuberculosis as a chronic rectal mass mimicking rectal prolapse in a child-a case report. 61
30568795 2018
19
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 61
30587190 2018
20
Primary Appendicular Malignancy Presenting as Abdominal Wall Abscess with Secondary Tuberculosis Infection: an Interesting Case Report. 61
30538401 2018
21
Gastric Tuberculosis Presenting as a Subepithelial Mass: A Rare Cause of Gastrointestinal Bleeding. 61
30642149 2018
22
Acquired zinc deficiency in a renal transplant recipient with gastrointestinal tuberculosis responding promptly to oral correction. 61
30381519 2018
23
[Gastric tuberculosis in an elderly patient:a case report]. 61
30416160 2018
24
Gastrointestinal Tuberculosis Presenting as Malnutrition and Distal Colonic Bowel Obstruction. 61
29682364 2018
25
Clinical and laboratory features of intestinal tuberculosis. 61
29559804 2018
26
Tuberculous Enteritis Presenting as Acute Appendicitis and Perirectal Abscess. 61
29560012 2018
27
Perforated tuberculous appendicitis: a rare case report. 61
29881313 2018
28
Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation. 61
29179699 2017
29
A Rare Thermophilic Bug in Complicated Diverticular Abscess. 61
29118685 2017
30
[Gastrointestinal tuberculosis as a cause of massive gastrointestinal bleeding in a patient with HIV infection]. 61
29165521 2017
31
Gastric outlet obstruction: an unusual case of primary duodenal tuberculosis. 61
28343151 2017
32
Ileocaecal and transverse colonic tuberculosis mimicking colonic malignancy - A case report. 61
28486175 2017
33
Kaleidoscopic View of Bowel Tuberculosis on Multi- Detector Computed Tomography (CT) Enterography - A Novel Technique Unfolding an Archaic Disease. 61
29657645 2017
34
The HIV manifestations within the gastrointestinal tract: A pictorial review. 61
31754480 2017
35
Gastrointestinal Tuberculosis. 61
28084201 2016
36
Clinico-Pathological Profile and Surgical Outcome of Patients of Gastrointestinal Tuberculosis Undergoing Laparotomy. 61
28044950 2016
37
A retrospective cohort study of 756 cases of abdominal tuberculosis: Two decades single centre experience. 61
27998497 2016
38
Role of mitochondrial oxidative stress on lymphocyte homeostasis in patients diagnosed with extra-pulmonary tuberculosis. 61
26431927 2016
39
The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review. 61
27123348 2016
40
[Asymptomatic Synchronous Tuberculosis Involving Stomach and Small Bowel in Immunocompetent Patient]. 61
26691192 2015
41
Abdomen agudo perforativo por tuberculosis intestinal. 61
28590101 2015
42
Management of Severe Gastrointestinal Tuberculosis with Injectable Antituberculous Drugs. 61
26543395 2015
43
Intermittent Directly Observed Therapy for Abdominal Tuberculosis: A Multicenter Randomized Controlled Trial Comparing 6 Months Versus 9 Months of Therapy. 61
25969531 2015
44
Intestinal Flora Modification of Arthritis Pattern in Spondyloarthropathy. 61
26267718 2015
45
Radiological findings in duodenal tuberculosis: a 15-year experience. 61
25416003 2015
46
Non-healing gastro-duodenal ulcer: A rare presentation of primary abdominal tuberculosis. 61
25506841 2015
47
Abdominal tuberculosis mimicking Crohn's disease's exacerbation: A clinical, diagnostic and surgical dilemma. A case report. 61
25528041 2015
48
Tuberculosis infection causing intestinal perforations in 2 patients with systemic lupus erythematosus. 61
25036568 2014
49
Tubercular duodenal, jejunal and ileocecal stricture in a patient. 61
24334467 2013
50
Esophageal tuberculosis presenting with hematemesis. 61
24255751 2013
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Variations for Gastrointestinal Tuberculosis

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Expression for Gastrointestinal Tuberculosis

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Search GEO for disease gene expression data for Gastrointestinal Tuberculosis.
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Pathways for Gastrointestinal Tuberculosis

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Pathways related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
4-1BB Pathway 63
Show member pathways
 12.33 TNF TBP IFNG CD4
2
Th17 cell differentiation 36
Show member pathways
 12.24 TNF NOD2 IFNG CD4
3
Folate Metabolism 1
Show member pathways
 11.79 TNF IFNG CRP ALB
4
Innate Lymphoid Cell Differentiation Pathways 64
11.45 TNF IFNG CD4
5
Th1 Differentiation Pathway 64
Show member pathways
 11.38 TNF IFNG CD4
6
Dendritic Cells Developmental Lineage Pathway 64
11.3 TNF IFNG CD4
7
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
10.99 TNF IFNG CEACAM5 CD4
8
Overview of nanoparticle effects 1
10.74 TNF CRP
9
Cytokines and Inflammatory Response 1
10.59 TNF IFNG CD4
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GO Terms for Gastrointestinal Tuberculosis

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Cellular components related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TNF IFNG GPT GP2 CRP ALB
2 cell surface GO:0009986 9.1 TNF NOD2 GP2 CEACAM5 CD4 ADA

Biological processes related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.65 TNF NOD2 CRP
2 positive regulation of interleukin-6 production GO:0032755 9.61 TNF NOD2 IFNG
3 positive regulation of amyloid-beta formation GO:1902004 9.56 TNF IFNG
4 embryonic digestive tract development GO:0048566 9.55 TNF ADA
5 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.54 NOD2 IFNG
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 TNF IFNG
7 positive regulation of calcium-mediated signaling GO:0050850 9.51 CD4 ADA
8 positive regulation of interleukin-1 beta production GO:0032731 9.5 TNF NOD2 IFNG
9 astrocyte activation GO:0048143 9.49 TNF IFNG
10 negative regulation of amyloid-beta clearance GO:1900222 9.46 TNF IFNG
11 positive regulation of phagocytosis GO:0050766 9.43 TNF NOD2 IFNG
12 negative regulation of lipid storage GO:0010888 9.4 TNF CRP
13 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.37 TNF NOD2
14 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
15 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
16 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Molecular functions related to Gastrointestinal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.92 TBP NOD2 CUTA CD4
Sources

Sources for Gastrointestinal Tuberculosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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