Gastrointestinal Tularemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GST018 MIFTS: 28	Gastrointestinal Tularemia Categories: Gastrointestinal diseases, Infectious diseases
Genes Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Gastrointestinal Tularemia

MalaCards integrated aliases for Gastrointestinal Tularemia:

Name: Gastrointestinal Tularemia ¹² ¹⁵ ⁷¹

Enteric Tularemia ¹² ⁷¹

Intestinal Tularaemia ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14239

ICD9CM ³⁴ 021.1 021.8

SNOMED-CT ⁶⁷ 186292001 186298002

UMLS ⁷¹ C0029835 C0152942 C0494039

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Summaries for Gastrointestinal Tularemia

Disease Ontology : ¹² A tularemia that results in formation of ulcerative lesions located in gastrointestinal tract. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom muscle aches, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tularemia, also known as enteric tularemia, is related to typhoidal tularemia and nontuberculous mycobacterial lung disease. An important gene associated with Gastrointestinal Tularemia is IGSF3 (Immunoglobulin Superfamily Member 3), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are hematopoietic system and immune system

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Related Diseases for Gastrointestinal Tularemia

Diseases related to Gastrointestinal Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)

#	Related Disease	Score	Top Affiliating Genes
1	typhoidal tularemia	10.3	PDP1 CLPB
2	nontuberculous mycobacterial lung disease	10.2	TLR2 SLC11A1
3	indeterminate leprosy	10.2	TLR1 SLC11A1
4	anaerobic pneumonia	10.2	TLR6 TLR2
5	oculoglandular tularemia	10.2	TLR2 PDP1 CLPB
6	radial nerve lesion	10.2	TLR1 SLC11A1
7	mycobacterium abscessus	10.2	TLR2 TLR1
8	prosthetic joint infection	10.1	TLR4 TLR2
9	ulnar nerve lesion	10.1	TLR1 SLC11A1
10	tuberculous salpingitis	10.1	IRF8 CYBB
11	fungal keratitis	10.1	TLR4 TLR2
12	congenital cytomegalovirus	10.1	TLR4 TLR2
13	chronic purulent otitis media	10.1	TLR4 TLR2
14	campylobacteriosis	10.1	TLR4 SLC11A1
15	neisseria meningitidis infection	10.1	TLR4 TLR2
16	hereditary angioedema with normal c1inh	10.1	TLR4 TLR2
17	endometrial mixed adenocarcinoma	10.1	TLR2 MYD88
18	pneumonic plague	10.1	TLR4 TLR2
19	neurosyphilis	10.1	TLR6 TLR2 TLR1
20	dental pulp disease	10.0	TLR4 TLR2
21	testicular disease	10.0	TLR2 TLR1 SLC11A1
22	suppurative otitis media	10.0	TLR4 TLR2
23	chlamydia pneumonia	10.0	TLR4 TLR2
24	lyme disease	10.0	TLR6 TLR2 TLR1
25	human monocytic ehrlichiosis	10.0	TLR2 MYD88 CLPB
26	bubonic plague	10.0	TLR4 TLR2
27	filarial elephantiasis	10.0	TLR6 TLR4 TLR2
28	glanders	10.0	TLR4 MYD88
29	platelet glycoprotein iv deficiency	10.0	TLR6 TLR4 TLR2
30	urethritis	10.0	TLR4 TLR2
31	reactive arthritis	10.0	TLR4 TLR2 SLC11A1
32	bacteriuria	10.0	TLR4 TLR2 TLR1
33	melioidosis	10.0	TLR4 TLR2 TLR1
34	visceral leishmaniasis	9.9	TLR4 TLR2 SLC11A1
35	meningococcal meningitis	9.9	TLR4 TLR2
36	superficial basal cell carcinoma	9.9	TLR4 TLR2 MYD88
37	silo filler's disease	9.9	TLR4 TLR2 MYD88
38	klebsiella pneumonia	9.9	TLR4 TLR2 MYD88
39	streptococcus pneumonia	9.9	TLR4 TLR2 MYD88
40	herpangina	9.9	TLR4 TLR2 MYD88
41	perinatal necrotizing enterocolitis	9.9	TLR4 TLR2 MYD88
42	coccidiosis	9.9	TLR4 TLR2 MYD88
43	paracoccidioidomycosis	9.9	TLR4 TLR2 MYD88
44	opportunistic mycosis	9.9	TLR4 TLR2 MYD88
45	plague	9.9	TLR4 TLR2 MYD88
46	fungal infectious disease	9.9	TLR4 TLR2 MYD88
47	commensal bacterial infectious disease	9.9	TLR4 TLR2 MYD88
48	alveolar echinococcosis	9.9	TLR4 TLR2
49	legionellosis	9.9	TLR4 TLR2 MYD88
50	toxoplasmosis	9.8	TLR4 TLR2 MYD88

Graphical network of the top 20 diseases related to Gastrointestinal Tularemia:

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Symptoms & Phenotypes for Gastrointestinal Tularemia

MGI Mouse Phenotypes related to Gastrointestinal Tularemia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.97	ARG1 CYBB IGLL5 IRF1 IRF8 MYD88
2	immune system	MP:0005387	9.73	ARG1 CYBB IGLL5 IRF1 IRF8 MYD88
3	neoplasm	MP:0002006	9.23	CYBB IRF1 IRF8 MYD88 SLC11A1 TBX21

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Drugs & Therapeutics for Gastrointestinal Tularemia

Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tularemia

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Genetic Tests for Gastrointestinal Tularemia

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Anatomical Context for Gastrointestinal Tularemia

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Publications for Gastrointestinal Tularemia

Articles related to Gastrointestinal Tularemia:

#	Title	Authors	PMID	Year
1	A combined enrichment and aptamer pulldown assay for Francisella tularensis detection in food and environmental matrices. ⁶¹	Lamont EA...Sreevatsan S	25536105	2014

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Genes for Gastrointestinal Tularemia

Genes related to Gastrointestinal Tularemia (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGSF3	Immunoglobulin Superfamily Member 3	Protein Coding	5.92	DISEASES inferred ¹⁵
2	PDP1	Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1	Protein Coding	5.23	DISEASES inferred ¹⁵
3	CLPB	Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit B	Protein Coding	5.04	DISEASES inferred ¹⁵
4	IGLL5	Immunoglobulin Lambda Like Polypeptide 5	Protein Coding	4.47	DISEASES inferred ¹⁵
5	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	4.46	DISEASES inferred ¹⁵
6	IRF8	Interferon Regulatory Factor 8	Protein Coding	4.09	DISEASES inferred ¹⁵
7	TLR6	Toll Like Receptor 6	Protein Coding	4.02	DISEASES inferred ¹⁵
8	TLR2	Toll Like Receptor 2	Protein Coding	3.87	DISEASES inferred ¹⁵
9	TLR1	Toll Like Receptor 1	Protein Coding	3.8	DISEASES inferred ¹⁵
10	IRF1	Interferon Regulatory Factor 1	Protein Coding	3.77	DISEASES inferred ¹⁵
11	TLR4	Toll Like Receptor 4	Protein Coding	3.57	DISEASES inferred ¹⁵
12	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	3.51	DISEASES inferred ¹⁵
13	TBX21	T-Box Transcription Factor 21	Protein Coding	3.51	DISEASES inferred ¹⁵
14	ARG1	Arginase 1	Protein Coding	3.48	DISEASES inferred ¹⁵
15	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	3.19	DISEASES inferred ¹⁵

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Variations for Gastrointestinal Tularemia

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Expression for Gastrointestinal Tularemia

Search GEO for disease gene expression data for Gastrointestinal Tularemia.

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Pathways for Gastrointestinal Tularemia

Pathways related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.9	TLR6 TLR4 TLR2 TLR1 SLC11A1 MYD88
2	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.29	TLR6 TLR4 TLR2 TLR1 MYD88 CYBB
3	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.9	TLR6 TLR4 TLR2 TLR1 MYD88
4	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.59	TLR6 TLR4 TLR2 TLR1 MYD88
5	Salmonella infection (KEGG) ³⁶ Show member pathways Salmonella infection ³⁶	12.58	TLR6 TLR4 TLR2 MYD88
6	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²³ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²³ NOD-like Receptor Signaling Pathways ⁶⁴	12.54	TLR6 TLR4 TLR2 TLR1 MYD88 IRF1
7	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.47	TLR6 TLR4 TLR2 TLR1 MYD88
8	Antigen processing-Cross presentation ⁶⁵ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁵ Endosomal/Vacuolar pathway ⁶⁵ ER-Phagosome pathway ⁶⁵ Immune response Antigen presentation by MHC class I ²³	12.18	TLR6 TLR4 TLR2 TLR1 MYD88 CYBB
9	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.17	TLR4 TLR2 MYD88 CYBB
10	VEGF Pathway (Qiagen) ⁶³ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²³ Neurophilin interactions with VEGF and VEGFR ⁶⁵ VEGF Pathway ⁶³	12.17	TLR6 TLR4 TLR2 TLR1 MYD88 IRF8
11	Colorectal Cancer Metastasis ⁶³	12.09	TLR6 TLR4 TLR2 TLR1
12	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.08	TLR6 TLR4 TLR2 TLR1 MYD88
13	Phagosome ³⁶	12.04	TLR6 TLR4 TLR2 CYBB
14	Tuberculosis ³⁶	12.02	TLR6 TLR4 TLR2 TLR1 MYD88
15	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.92	TLR6 TLR4 TLR2 TLR1
16	Amoebiasis ³⁶	11.8	TLR4 TLR2 ARG1
17	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.75	TLR6 TLR4 TLR2 TLR1
18	Phagocytosis of Microbes ⁶³	11.71	TLR6 TLR4 TLR2 TLR1
19	NF-kappaB Signaling ⁴	11.68	TLR6 TLR2 TLR1 TBX21 MYD88 IRF8
20	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	11.65	TLR6 TLR4 TLR2 TLR1 MYD88 IRF1
21	Pertussis ³⁶	11.64	TLR4 MYD88 IRF8 IRF1
22	Legionellosis ³⁶	11.53	TLR4 TLR2 MYD88
23	Malaria ³⁶	11.46	TLR4 TLR2 MYD88
24	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.43	TLR6 TLR4 TLR2 TLR1 TBX21
25	Type II interferon signaling (IFNG) ¹	11.29	IRF8 IRF1 CYBB
26	IL1 and megakaryocytes in obesity ¹	11.08	TLR2 TLR1 MYD88
27	NTHi-Induced Signaling ⁶³	10.94	TLR2 MYD88

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GO Terms for Gastrointestinal Tularemia

Cellular components related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.63	TLR6 TLR4 TLR2 TLR1 SLC11A1 CYBB
2	phagocytic vesicle membrane	GO:0030670	9.02	TLR6 TLR2 TLR1 SLC11A1 CYBB
3	Toll-like receptor 1-Toll-like receptor 2 protein complex	GO:0035354	8.96	TLR2 TLR1

Biological processes related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show top 50) (show all 53)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.08	TLR6 TLR4 TLR2 TBX21 SLC11A1 MYD88
2	immune response	GO:0006955	10.07	TLR6 TLR4 TLR2 TLR1 SLC11A1 IRF8
3	immune system process	GO:0002376	10.03	TLR6 TLR4 TLR2 TLR1 MYD88 IRF8
4	cellular response to lipopolysaccharide	GO:0071222	9.96	TLR4 MYD88 IRF8 ARG1
5	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.96	TLR6 TLR4 TLR2 MYD88
6	response to lipopolysaccharide	GO:0032496	9.93	TLR4 TLR2 SLC11A1 MYD88 ARG1
7	defense response to bacterium	GO:0042742	9.93	TLR6 TLR4 SLC11A1 MYD88 IRF8 IGLL5
8	inflammatory response	GO:0006954	9.91	TLR6 TLR4 TLR2 TLR1 SLC11A1 MYD88
9	response to bacterium	GO:0009617	9.89	TLR4 SLC11A1 IRF8
10	cellular response to interferon-gamma	GO:0071346	9.88	TLR4 TLR2 IRF8
11	positive regulation of tumor necrosis factor production	GO:0032760	9.88	TLR4 TLR2 TLR1 MYD88
12	phagocytosis	GO:0006909	9.88	TLR4 SLC11A1 MYD88 IRF8
13	cellular response to mechanical stimulus	GO:0071260	9.87	TLR4 MYD88 IRF1
14	type I interferon signaling pathway	GO:0060337	9.86	MYD88 IRF8 IRF1
15	positive regulation of interferon-gamma production	GO:0032729	9.86	TLR4 SLC11A1 IRF8
16	positive regulation of chemokine production	GO:0032722	9.83	TLR4 TLR2 MYD88
17	positive regulation of interleukin-8 production	GO:0032757	9.83	TLR4 TLR2 TLR1 MYD88
18	positive regulation of interferon-beta production	GO:0032728	9.81	TLR4 TLR2 IRF1
19	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.81	TLR4 TLR2 MYD88
20	microglial cell activation	GO:0001774	9.8	TLR6 TLR2 TLR1
21	positive regulation of interleukin-6 production	GO:0032755	9.8	TLR6 TLR4 TLR2 TLR1 MYD88
22	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.78	TLR6 TLR4 MYD88
23	positive regulation of interleukin-12 production	GO:0032735	9.78	TLR4 TLR2 IRF8 IRF1
24	macrophage activation	GO:0042116	9.74	TLR4 TLR1 SLC11A1
25	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.73	TLR6 TLR4 MYD88
26	cell activation	GO:0001775	9.72	TLR6 TLR2 TLR1
27	positive regulation of macrophage activation	GO:0043032	9.71	TLR6 TLR4
28	positive regulation of reactive oxygen species biosynthetic process	GO:1903428	9.71	TLR6 TLR4
29	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.71	TLR4 TLR2
30	respiratory burst	GO:0045730	9.71	SLC11A1 CYBB
31	I-kappaB phosphorylation	GO:0007252	9.7	TLR4 TLR2
32	cellular response to lipoteichoic acid	GO:0071223	9.7	TLR4 TLR2
33	positive regulation of NLRP3 inflammasome complex assembly	GO:1900227	9.69	TLR6 TLR4
34	positive regulation of lymphocyte proliferation	GO:0050671	9.69	TLR4 MYD88
35	cellular response to bacterial lipopeptide	GO:0071221	9.69	TLR6 TLR2 TLR1
36	interleukin-1 beta production	GO:0032611	9.68	TLR6 TLR4
37	cellular response to diacyl bacterial lipopeptide	GO:0071726	9.68	TLR6 TLR2
38	negative regulation of T-helper 2 cell cytokine production	GO:2000552	9.68	TBX21 ARG1
39	positive regulation of oxidative stress-induced neuron death	GO:1903223	9.67	TLR6 TLR4
40	toll-like receptor TLR6:TLR2 signaling pathway	GO:0038124	9.67	TLR6 TLR2
41	toll-like receptor TLR1:TLR2 signaling pathway	GO:0038123	9.67	TLR2 TLR1
42	regulation of cytokine secretion	GO:0050707	9.67	TLR6 TLR2 TLR1
43	positive regulation of matrix metallopeptidase secretion	GO:1904466	9.65	TLR4 TLR2
44	cellular response to triacyl bacterial lipopeptide	GO:0071727	9.65	TLR2 TLR1
45	nitric oxide metabolic process	GO:0046209	9.64	TLR6 TLR2
46	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO:1903974	9.62	TLR4 TLR2
47	detection of diacyl bacterial lipopeptide	GO:0042496	9.62	TLR6 TLR2
48	defense response to protozoan	GO:0042832	9.62	SLC11A1 MYD88 IRF8 ARG1
49	detection of triacyl bacterial lipopeptide	GO:0042495	9.61	TLR2 TLR1
50	innate immune response	GO:0045087	9.61	TLR6 TLR4 TLR2 TLR1 MYD88 IRF1

Molecular functions related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hydrolase activity	GO:0016787	10.02	TLR6 TLR4 TLR2 TLR1 PDP1 CLPB
2	transmembrane signaling receptor activity	GO:0004888	9.73	TLR6 TLR4 TLR2 TLR1
3	signaling receptor activity	GO:0038023	9.71	TLR6 TLR4 TLR2 TLR1
4	amyloid-beta binding	GO:0001540	9.63	TLR6 TLR4 TLR2
5	Toll-like receptor binding	GO:0035325	9.37	TLR2 MYD88
6	lipopeptide binding	GO:0071723	9.33	TLR6 TLR2 TLR1
7	lipopolysaccharide receptor activity	GO:0001875	9.32	TLR4 TLR2
8	Toll-like receptor 2 binding	GO:0035663	9.26	TLR6 TLR1
9	NAD+ nucleotidase, cyclic ADP-ribose generating	GO:0061809	9.26	TLR6 TLR4 TLR2 TLR1
10	NAD(P)+ nucleosidase activity	GO:0050135	8.92	TLR6 TLR4 TLR2 TLR1

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Sources for Gastrointestinal Tularemia

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