MCID: GST018
MIFTS: 28

Gastrointestinal Tularemia

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Gastrointestinal Tularemia

MalaCards integrated aliases for Gastrointestinal Tularemia:

Name: Gastrointestinal Tularemia 12 15 71
Enteric Tularemia 12 71
Intestinal Tularaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14239
ICD9CM 34 021.1 021.8
SNOMED-CT 67 186292001 186298002
UMLS 71 C0029835 C0152942 C0494039

Summaries for Gastrointestinal Tularemia

Disease Ontology : 12 A tularemia that results in formation of ulcerative lesions located in gastrointestinal tract. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom muscle aches, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tularemia, also known as enteric tularemia, is related to typhoidal tularemia and nontuberculous mycobacterial lung disease. An important gene associated with Gastrointestinal Tularemia is IGSF3 (Immunoglobulin Superfamily Member 3), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are hematopoietic system and immune system

Related Diseases for Gastrointestinal Tularemia

Diseases related to Gastrointestinal Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 typhoidal tularemia 10.3 PDP1 CLPB
2 nontuberculous mycobacterial lung disease 10.2 TLR2 SLC11A1
3 indeterminate leprosy 10.2 TLR1 SLC11A1
4 anaerobic pneumonia 10.2 TLR6 TLR2
5 oculoglandular tularemia 10.2 TLR2 PDP1 CLPB
6 radial nerve lesion 10.2 TLR1 SLC11A1
7 mycobacterium abscessus 10.2 TLR2 TLR1
8 prosthetic joint infection 10.1 TLR4 TLR2
9 ulnar nerve lesion 10.1 TLR1 SLC11A1
10 tuberculous salpingitis 10.1 IRF8 CYBB
11 fungal keratitis 10.1 TLR4 TLR2
12 congenital cytomegalovirus 10.1 TLR4 TLR2
13 chronic purulent otitis media 10.1 TLR4 TLR2
14 campylobacteriosis 10.1 TLR4 SLC11A1
15 neisseria meningitidis infection 10.1 TLR4 TLR2
16 hereditary angioedema with normal c1inh 10.1 TLR4 TLR2
17 endometrial mixed adenocarcinoma 10.1 TLR2 MYD88
18 pneumonic plague 10.1 TLR4 TLR2
19 neurosyphilis 10.1 TLR6 TLR2 TLR1
20 dental pulp disease 10.0 TLR4 TLR2
21 testicular disease 10.0 TLR2 TLR1 SLC11A1
22 suppurative otitis media 10.0 TLR4 TLR2
23 chlamydia pneumonia 10.0 TLR4 TLR2
24 lyme disease 10.0 TLR6 TLR2 TLR1
25 human monocytic ehrlichiosis 10.0 TLR2 MYD88 CLPB
26 bubonic plague 10.0 TLR4 TLR2
27 filarial elephantiasis 10.0 TLR6 TLR4 TLR2
28 glanders 10.0 TLR4 MYD88
29 platelet glycoprotein iv deficiency 10.0 TLR6 TLR4 TLR2
30 urethritis 10.0 TLR4 TLR2
31 reactive arthritis 10.0 TLR4 TLR2 SLC11A1
32 bacteriuria 10.0 TLR4 TLR2 TLR1
33 melioidosis 10.0 TLR4 TLR2 TLR1
34 visceral leishmaniasis 9.9 TLR4 TLR2 SLC11A1
35 meningococcal meningitis 9.9 TLR4 TLR2
36 superficial basal cell carcinoma 9.9 TLR4 TLR2 MYD88
37 silo filler's disease 9.9 TLR4 TLR2 MYD88
38 klebsiella pneumonia 9.9 TLR4 TLR2 MYD88
39 streptococcus pneumonia 9.9 TLR4 TLR2 MYD88
40 herpangina 9.9 TLR4 TLR2 MYD88
41 perinatal necrotizing enterocolitis 9.9 TLR4 TLR2 MYD88
42 coccidiosis 9.9 TLR4 TLR2 MYD88
43 paracoccidioidomycosis 9.9 TLR4 TLR2 MYD88
44 opportunistic mycosis 9.9 TLR4 TLR2 MYD88
45 plague 9.9 TLR4 TLR2 MYD88
46 fungal infectious disease 9.9 TLR4 TLR2 MYD88
47 commensal bacterial infectious disease 9.9 TLR4 TLR2 MYD88
48 alveolar echinococcosis 9.9 TLR4 TLR2
49 legionellosis 9.9 TLR4 TLR2 MYD88
50 toxoplasmosis 9.8 TLR4 TLR2 MYD88

Graphical network of the top 20 diseases related to Gastrointestinal Tularemia:



Diseases related to Gastrointestinal Tularemia

Symptoms & Phenotypes for Gastrointestinal Tularemia

MGI Mouse Phenotypes related to Gastrointestinal Tularemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ARG1 CYBB IGLL5 IRF1 IRF8 MYD88
2 immune system MP:0005387 9.73 ARG1 CYBB IGLL5 IRF1 IRF8 MYD88
3 neoplasm MP:0002006 9.23 CYBB IRF1 IRF8 MYD88 SLC11A1 TBX21

Drugs & Therapeutics for Gastrointestinal Tularemia

Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tularemia

Genetic Tests for Gastrointestinal Tularemia

Anatomical Context for Gastrointestinal Tularemia

Publications for Gastrointestinal Tularemia

Articles related to Gastrointestinal Tularemia:

# Title Authors PMID Year
1
A combined enrichment and aptamer pulldown assay for Francisella tularensis detection in food and environmental matrices. 61
25536105 2014

Variations for Gastrointestinal Tularemia

Expression for Gastrointestinal Tularemia

Search GEO for disease gene expression data for Gastrointestinal Tularemia.

Pathways for Gastrointestinal Tularemia

Pathways related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 TLR6 TLR4 TLR2 TLR1 SLC11A1 MYD88
2
Show member pathways
13.29 TLR6 TLR4 TLR2 TLR1 MYD88 CYBB
3
Show member pathways
12.9 TLR6 TLR4 TLR2 TLR1 MYD88
4
Show member pathways
12.59 TLR6 TLR4 TLR2 TLR1 MYD88
5
Show member pathways
12.58 TLR6 TLR4 TLR2 MYD88
6
Show member pathways
12.54 TLR6 TLR4 TLR2 TLR1 MYD88 IRF1
7
Show member pathways
12.47 TLR6 TLR4 TLR2 TLR1 MYD88
8
Show member pathways
12.18 TLR6 TLR4 TLR2 TLR1 MYD88 CYBB
9
Show member pathways
12.17 TLR4 TLR2 MYD88 CYBB
10
Show member pathways
12.17 TLR6 TLR4 TLR2 TLR1 MYD88 IRF8
11 12.09 TLR6 TLR4 TLR2 TLR1
12
Show member pathways
12.08 TLR6 TLR4 TLR2 TLR1 MYD88
13 12.04 TLR6 TLR4 TLR2 CYBB
14 12.02 TLR6 TLR4 TLR2 TLR1 MYD88
15
Show member pathways
11.92 TLR6 TLR4 TLR2 TLR1
16 11.8 TLR4 TLR2 ARG1
17
Show member pathways
11.75 TLR6 TLR4 TLR2 TLR1
18 11.71 TLR6 TLR4 TLR2 TLR1
19 11.68 TLR6 TLR2 TLR1 TBX21 MYD88 IRF8
20
Show member pathways
11.65 TLR6 TLR4 TLR2 TLR1 MYD88 IRF1
21 11.64 TLR4 MYD88 IRF8 IRF1
22 11.53 TLR4 TLR2 MYD88
23 11.46 TLR4 TLR2 MYD88
24
Show member pathways
11.43 TLR6 TLR4 TLR2 TLR1 TBX21
25 11.29 IRF8 IRF1 CYBB
26 11.08 TLR2 TLR1 MYD88
27 10.94 TLR2 MYD88

GO Terms for Gastrointestinal Tularemia

Cellular components related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 TLR6 TLR4 TLR2 TLR1 SLC11A1 CYBB
2 phagocytic vesicle membrane GO:0030670 9.02 TLR6 TLR2 TLR1 SLC11A1 CYBB
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR2 TLR1

Biological processes related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TLR6 TLR4 TLR2 TBX21 SLC11A1 MYD88
2 immune response GO:0006955 10.07 TLR6 TLR4 TLR2 TLR1 SLC11A1 IRF8
3 immune system process GO:0002376 10.03 TLR6 TLR4 TLR2 TLR1 MYD88 IRF8
4 cellular response to lipopolysaccharide GO:0071222 9.96 TLR4 MYD88 IRF8 ARG1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TLR6 TLR4 TLR2 MYD88
6 response to lipopolysaccharide GO:0032496 9.93 TLR4 TLR2 SLC11A1 MYD88 ARG1
7 defense response to bacterium GO:0042742 9.93 TLR6 TLR4 SLC11A1 MYD88 IRF8 IGLL5
8 inflammatory response GO:0006954 9.91 TLR6 TLR4 TLR2 TLR1 SLC11A1 MYD88
9 response to bacterium GO:0009617 9.89 TLR4 SLC11A1 IRF8
10 cellular response to interferon-gamma GO:0071346 9.88 TLR4 TLR2 IRF8
11 positive regulation of tumor necrosis factor production GO:0032760 9.88 TLR4 TLR2 TLR1 MYD88
12 phagocytosis GO:0006909 9.88 TLR4 SLC11A1 MYD88 IRF8
13 cellular response to mechanical stimulus GO:0071260 9.87 TLR4 MYD88 IRF1
14 type I interferon signaling pathway GO:0060337 9.86 MYD88 IRF8 IRF1
15 positive regulation of interferon-gamma production GO:0032729 9.86 TLR4 SLC11A1 IRF8
16 positive regulation of chemokine production GO:0032722 9.83 TLR4 TLR2 MYD88
17 positive regulation of interleukin-8 production GO:0032757 9.83 TLR4 TLR2 TLR1 MYD88
18 positive regulation of interferon-beta production GO:0032728 9.81 TLR4 TLR2 IRF1
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TLR4 TLR2 MYD88
20 microglial cell activation GO:0001774 9.8 TLR6 TLR2 TLR1
21 positive regulation of interleukin-6 production GO:0032755 9.8 TLR6 TLR4 TLR2 TLR1 MYD88
22 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.78 TLR6 TLR4 MYD88
23 positive regulation of interleukin-12 production GO:0032735 9.78 TLR4 TLR2 IRF8 IRF1
24 macrophage activation GO:0042116 9.74 TLR4 TLR1 SLC11A1
25 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.73 TLR6 TLR4 MYD88
26 cell activation GO:0001775 9.72 TLR6 TLR2 TLR1
27 positive regulation of macrophage activation GO:0043032 9.71 TLR6 TLR4
28 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.71 TLR6 TLR4
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR4 TLR2
30 respiratory burst GO:0045730 9.71 SLC11A1 CYBB
31 I-kappaB phosphorylation GO:0007252 9.7 TLR4 TLR2
32 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2
33 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.69 TLR6 TLR4
34 positive regulation of lymphocyte proliferation GO:0050671 9.69 TLR4 MYD88
35 cellular response to bacterial lipopeptide GO:0071221 9.69 TLR6 TLR2 TLR1
36 interleukin-1 beta production GO:0032611 9.68 TLR6 TLR4
37 cellular response to diacyl bacterial lipopeptide GO:0071726 9.68 TLR6 TLR2
38 negative regulation of T-helper 2 cell cytokine production GO:2000552 9.68 TBX21 ARG1
39 positive regulation of oxidative stress-induced neuron death GO:1903223 9.67 TLR6 TLR4
40 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.67 TLR6 TLR2
41 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.67 TLR2 TLR1
42 regulation of cytokine secretion GO:0050707 9.67 TLR6 TLR2 TLR1
43 positive regulation of matrix metallopeptidase secretion GO:1904466 9.65 TLR4 TLR2
44 cellular response to triacyl bacterial lipopeptide GO:0071727 9.65 TLR2 TLR1
45 nitric oxide metabolic process GO:0046209 9.64 TLR6 TLR2
46 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.62 TLR4 TLR2
47 detection of diacyl bacterial lipopeptide GO:0042496 9.62 TLR6 TLR2
48 defense response to protozoan GO:0042832 9.62 SLC11A1 MYD88 IRF8 ARG1
49 detection of triacyl bacterial lipopeptide GO:0042495 9.61 TLR2 TLR1
50 innate immune response GO:0045087 9.61 TLR6 TLR4 TLR2 TLR1 MYD88 IRF1

Molecular functions related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 10.02 TLR6 TLR4 TLR2 TLR1 PDP1 CLPB
2 transmembrane signaling receptor activity GO:0004888 9.73 TLR6 TLR4 TLR2 TLR1
3 signaling receptor activity GO:0038023 9.71 TLR6 TLR4 TLR2 TLR1
4 amyloid-beta binding GO:0001540 9.63 TLR6 TLR4 TLR2
5 Toll-like receptor binding GO:0035325 9.37 TLR2 MYD88
6 lipopeptide binding GO:0071723 9.33 TLR6 TLR2 TLR1
7 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
8 Toll-like receptor 2 binding GO:0035663 9.26 TLR6 TLR1
9 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.26 TLR6 TLR4 TLR2 TLR1
10 NAD(P)+ nucleosidase activity GO:0050135 8.92 TLR6 TLR4 TLR2 TLR1

Sources for Gastrointestinal Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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