Gastrointestinal Tularemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Gastrointestinal Tularemia

MalaCards integrated aliases for Gastrointestinal Tularemia:

Name: Gastrointestinal Tularemia ¹² ¹⁵ ⁷¹

Enteric Tularemia ¹² ⁷¹

Intestinal Tularaemia ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14239

ICD9CM ³⁴ 021.1 021.8

SNOMED-CT ⁶⁷ 62769007

UMLS ⁷¹ C0029835 C0152942 C0494039

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Summaries for Gastrointestinal Tularemia

Disease Ontology : ¹² A tularemia that results in formation of ulcerative lesions located in gastrointestinal tract. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom muscle aches, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tularemia, also known as enteric tularemia, is related to typhoidal tularemia and oculoglandular tularemia. An important gene associated with Gastrointestinal Tularemia is IGSF3 (Immunoglobulin Superfamily Member 3), and among its related pathways/superpathways are NF-KappaB Family Pathway and TRAF Pathway. Related phenotypes are hematopoietic system and immune system

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Related Diseases for Gastrointestinal Tularemia

Diseases related to Gastrointestinal Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Related Disease	Score	Top Affiliating Genes
1	typhoidal tularemia	10.4	PDP1 CLPB
2	oculoglandular tularemia	10.4	PDP1 CLPB
3	nontuberculous mycobacterial lung disease	10.3	TLR2 SLC11A1
4	human monocytic ehrlichiosis	10.1	MYD88 CLPB
5	prosthetic joint infection	9.9	TLR4 TLR2
6	campylobacteriosis	9.9	TLR4 SLC11A1
7	fungal keratitis	9.9	TLR4 TLR2
8	neisseria meningitidis infection	9.8	TLR4 TLR2
9	spondylarthropathy	9.8	TLR4 TLR2
10	pneumonic plague	9.8	TLR4 TLR2
11	combat disorder	9.8	TLR4 TLR2
12	chlamydia pneumonia	9.8	TLR4 TLR2
13	dental pulp disease	9.7	TLR4 TLR2
14	suppurative otitis media	9.7	TLR4 TLR2
15	bubonic plague	9.7	TLR4 TLR2
16	splenic disease	9.7	TLR4 TLR2 SLC11A1
17	amebiasis	9.7	TLR4 TLR2 IGLL5
18	testicular disease	9.7	TLR4 TLR2 SLC11A1
19	meningococcal meningitis	9.7	TLR4 TLR2
20	leprosy 3	9.7	TLR4 TLR2 SLC11A1
21	visceral leishmaniasis	9.7	TLR4 TLR2 SLC11A1
22	reactive arthritis	9.7	TLR4 TLR2 SLC11A1
23	cervicitis	9.6	TLR4 TLR2
24	pulmonary tuberculosis	9.6	TLR4 TLR2 SLC11A1
25	urethritis	9.6	TLR4 TLR2
26	filarial elephantiasis	9.6	TLR4 TLR2
27	superficial basal cell carcinoma	9.5	TLR4 TLR2 MYD88
28	silo filler's disease	9.5	TLR4 TLR2 MYD88
29	myd88 deficiency	9.5	TLR4 TLR2 MYD88
30	irak4 deficiency	9.5	TLR4 TLR2 MYD88
31	anogenital venereal wart	9.5	TLR4 TLR2 MYD88
32	streptococcus pneumonia	9.5	TLR4 TLR2 MYD88
33	coccidiosis	9.5	TLR4 TLR2 MYD88
34	paracoccidioidomycosis	9.5	TLR4 TLR2 MYD88
35	bacterial sepsis	9.5	TLR4 TLR2 MYD88
36	plague	9.5	TLR4 TLR2 MYD88
37	legionellosis	9.5	TLR4 TLR2 MYD88
38	alveolar echinococcosis	9.5	TLR4 TLR2
39	parasitic protozoa infectious disease	9.5	TLR4 TLR2 MYD88
40	toxoplasmosis	9.4	TLR4 TLR2 MYD88
41	pertussis	9.4	TLR4 MYD88 IRF1
42	trypanosomiasis	9.4	TLR4 TLR2 MYD88
43	chagas disease	9.4	TLR4 TLR2 MYD88
44	respiratory allergy	9.4	TLR4 TLR2 TBX21
45	bronchial disease	9.4	TLR4 TLR2 TBX21
46	autoimmune disease of central nervous system	9.4	TLR4 TLR2 TBX21
47	pneumonic tularemia	9.3	TLR4 TLR2 MYD88 CLPB
48	blood group, globoside system	9.3	TLR4 TLR2
49	salmonellosis	9.3	TLR4 TLR2 SLC11A1 MYD88
50	cutaneous leishmaniasis	9.3	TLR4 TLR2 SLC11A1 ARG1

Graphical network of the top 20 diseases related to Gastrointestinal Tularemia:

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Symptoms & Phenotypes for Gastrointestinal Tularemia

MGI Mouse Phenotypes related to Gastrointestinal Tularemia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.9	ARG1 BAZ2B CYBB IGLL5 IRF1 IRF8
2	immune system	MP:0005387	9.7	ARG1 BAZ2B CYBB IGLL5 IRF1 IRF8
3	neoplasm	MP:0002006	9.28	CYBB IRF1 IRF8 MAP3K5 MYD88 SLC11A1

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Drugs & Therapeutics for Gastrointestinal Tularemia

Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tularemia

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Genetic Tests for Gastrointestinal Tularemia

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Anatomical Context for Gastrointestinal Tularemia

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Publications for Gastrointestinal Tularemia

Articles related to Gastrointestinal Tularemia:

#	Title	Authors	PMID	Year
1	A combined enrichment and aptamer pulldown assay for Francisella tularensis detection in food and environmental matrices. ⁶¹	Lamont EA...Sreevatsan S	25536105	2014

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Genes for Gastrointestinal Tularemia

Genes related to Gastrointestinal Tularemia (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGSF3	Immunoglobulin Superfamily Member 3	Protein Coding	5.57	DISEASES inferred ¹⁵
2	PDP1	Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1	Protein Coding	5.16	DISEASES inferred ¹⁵
3	CLPB	Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit B	Protein Coding	5.13	DISEASES inferred ¹⁵
4	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	4.53	DISEASES inferred ¹⁵
5	IGLL5	Immunoglobulin Lambda Like Polypeptide 5	Protein Coding	4.51	DISEASES inferred ¹⁵
6	BAZ2B	Bromodomain Adjacent To Zinc Finger Domain 2B	Protein Coding	4.3	DISEASES inferred ¹⁵
7	IRF8	Interferon Regulatory Factor 8	Protein Coding	4.21	DISEASES inferred ¹⁵
8	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	3.97	DISEASES inferred ¹⁵
9	IRF1	Interferon Regulatory Factor 1	Protein Coding	3.8	DISEASES inferred ¹⁵
10	TLR2	Toll Like Receptor 2	Protein Coding	3.7	DISEASES inferred ¹⁵
11	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	3.62	DISEASES inferred ¹⁵
12	ARG1	Arginase 1	Protein Coding	3.61	DISEASES inferred ¹⁵
13	TBX21	T-Box Transcription Factor 21	Protein Coding	3.59	DISEASES inferred ¹⁵
14	TLR4	Toll Like Receptor 4	Protein Coding	3.53	DISEASES inferred ¹⁵
15	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	3.29	DISEASES inferred ¹⁵

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Variations for Gastrointestinal Tularemia

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Expression for Gastrointestinal Tularemia

Search GEO for disease gene expression data for Gastrointestinal Tularemia.

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Pathways for Gastrointestinal Tularemia

Pathways related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.46	TLR4 TLR2 MYD88 MAP3K5
2	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.33	TLR4 TLR2 MYD88 MAP3K5
3	Antigen processing-Cross presentation ⁶⁵ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁵ Endosomal/Vacuolar pathway ⁶⁵ ER-Phagosome pathway ⁶⁵ Immune response Antigen presentation by MHC class I ²²	12.18	TLR4 TLR2 MYD88 CYBB
4	VEGF Pathway (Qiagen) ⁶⁵ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² VEGF Family Ligands and Receptor Interactions ⁶³ VEGF Pathway ⁶³	12.13	TLR4 TLR2 MYD88 IRF8
5	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	11.95	TLR4 TLR2 MYD88 CYBB
6	Phagosome ³⁶	11.91	TLR4 TLR2 CYBB
7	NF-kappaB Signaling ⁴	11.87	TLR2 TBX21 MYD88 IRF8 IRF1
8	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁴	11.8	TLR4 TLR2 TBX21
9	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	11.78	TLR4 TLR2 MYD88 IRF1
10	Amoebiasis ³⁶	11.66	TLR4 TLR2 ARG1
11	Legionellosis ³⁶	11.34	TLR4 TLR2 MYD88
12	Malaria ³⁶	11.2	TLR4 TLR2 MYD88
13	IL1 and megakaryocytes in obesity ¹	10.96	TLR2 MYD88
14	Type II interferon signaling (IFNG) ¹	10.9	IRF8 IRF1 CYBB
15	NTHi-Induced Signaling ⁶³	10.85	TLR2 MYD88
16	Pertussis ³⁶	10.81	TLR4 MYD88 IRF8 IRF1

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GO Terms for Gastrointestinal Tularemia

Cellular components related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phagocytic vesicle membrane	GO:0030670	8.8	TLR2 SLC11A1 CYBB

Biological processes related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 37)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.11	TLR4 TLR2 TBX21 SLC11A1 IRF8 IRF1
2	positive regulation of gene expression	GO:0010628	9.97	TLR4 TLR2 TBX21 SLC11A1 MYD88
3	inflammatory response	GO:0006954	9.91	TLR4 TLR2 SLC11A1 MYD88 CYBB
4	cellular response to lipopolysaccharide	GO:0071222	9.87	TLR4 MYD88 IRF8 ARG1
5	response to lipopolysaccharide	GO:0032496	9.86	TLR4 TLR2 SLC11A1 ARG1
6	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.85	TLR4 TLR2 MYD88
7	response to bacterium	GO:0009617	9.82	TLR4 SLC11A1 IRF8
8	cellular response to interferon-gamma	GO:0071346	9.81	TLR4 TLR2 IRF8
9	cellular response to mechanical stimulus	GO:0071260	9.78	TLR4 MYD88 IRF1
10	type I interferon signaling pathway	GO:0060337	9.77	MYD88 IRF8 IRF1
11	positive regulation of interleukin-6 production	GO:0032755	9.76	TLR4 TLR2 MYD88
12	defense response to bacterium	GO:0042742	9.72	TLR4 SLC11A1 MYD88 IRF8 IGLL5
13	positive regulation of interferon-gamma production	GO:0032729	9.71	TLR4 SLC11A1 IRF8
14	toll-like receptor signaling pathway	GO:0002224	9.7	TLR4 TLR2 MYD88
15	immune system process	GO:0002376	9.7	TLR4 TLR2 MYD88 MAP3K5 IRF8 IRF1
16	positive regulation of interleukin-10 production	GO:0032733	9.67	TLR4 TLR2
17	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.67	TLR4 MYD88
18	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.67	TLR4 TLR2 MYD88
19	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	9.66	TLR4 CYBB
20	positive regulation of chemokine production	GO:0032722	9.66	TLR4 TLR2
21	positive regulation of interleukin-8 secretion	GO:2000484	9.65	TLR4 TLR2
22	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.65	TLR4 TLR2
23	respiratory burst	GO:0045730	9.64	SLC11A1 CYBB
24	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.63	TLR4 MYD88
25	I-kappaB phosphorylation	GO:0007252	9.62	TLR4 TLR2
26	macrophage activation	GO:0042116	9.62	TLR4 SLC11A1
27	cellular response to lipoteichoic acid	GO:0071223	9.61	TLR4 TLR2
28	positive regulation of interleukin-8 production	GO:0032757	9.61	TLR4 TLR2 MYD88
29	positive regulation of interleukin-12 biosynthetic process	GO:0045084	9.59	TLR4 IRF1
30	positive regulation of interleukin-12 production	GO:0032735	9.58	TLR4 TLR2 IRF8
31	phagocytosis	GO:0006909	9.56	TLR4 SLC11A1 MYD88 IRF8
32	negative regulation of T-helper 2 cell cytokine production	GO:2000552	9.55	TBX21 ARG1
33	positive regulation of interferon-beta production	GO:0032728	9.54	TLR4 TLR2 IRF1
34	positive regulation of matrix metallopeptidase secretion	GO:1904466	9.48	TLR4 TLR2
35	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO:1903974	9.46	TLR4 TLR2
36	defense response to protozoan	GO:0042832	9.26	SLC11A1 MYD88 IRF8 ARG1
37	innate immune response	GO:0045087	9.23	TLR4 TLR2 MYD88 MAP3K5 IRF1 IGLL5

Molecular functions related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Toll-like receptor binding	GO:0035325	8.96	TLR2 MYD88
2	lipopolysaccharide receptor activity	GO:0001875	8.62	TLR4 TLR2

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