Gastrointestinal Tularemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Gastrointestinal Tularemia

MalaCards integrated aliases for Gastrointestinal Tularemia:

Name: Gastrointestinal Tularemia ¹² ¹⁵ ⁷¹

Enteric Tularemia ¹² ⁷¹

Intestinal Tularaemia ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14239

ICD9CM ³⁴ 021.1 021.8

UMLS ⁷¹ C0029835 C0152942 C0494039

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Summaries for Gastrointestinal Tularemia

Disease Ontology : ¹² A tularemia that results in formation of ulcerative lesions located in gastrointestinal tract. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom muscle aches, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tularemia, also known as enteric tularemia, is related to typhoidal tularemia and oculoglandular tularemia. An important gene associated with Gastrointestinal Tularemia is IGSF3 (Immunoglobulin Superfamily Member 3), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and NF-KappaB Family Pathway. Related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Gastrointestinal Tularemia

Diseases related to Gastrointestinal Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)

#	Related Disease	Score	Top Affiliating Genes
1	typhoidal tularemia	10.4	PDP1 CLPB
2	oculoglandular tularemia	10.4	PDP1 CLPB
3	nontuberculous mycobacterial lung disease	10.2	TLR2 SLC11A1
4	human monocytic ehrlichiosis	9.9	TLR2 MYD88 CLPB
5	prosthetic joint infection	9.9	TLR4 TLR2
6	fungal keratitis	9.8	TLR4 TLR2
7	campylobacteriosis	9.8	TLR4 SLC11A1
8	neisseria meningitidis infection	9.8	TLR4 TLR2
9	spondylarthropathy	9.8	TLR4 TLR2
10	hereditary angioedema with normal c1inh	9.8	TLR4 TLR2
11	pneumonic plague	9.7	TLR4 TLR2
12	chlamydia pneumonia	9.7	TLR4 TLR2
13	combat disorder	9.7	TLR4 TLR2
14	suppurative otitis media	9.7	TLR4 TLR2
15	amebiasis	9.7	TLR4 TLR2 IGLL5
16	dental pulp disease	9.7	TLR4 TLR2
17	testicular disease	9.7	TLR4 TLR2 SLC11A1
18	leprosy 3	9.6	TLR4 TLR2 SLC11A1
19	visceral leishmaniasis	9.6	TLR4 TLR2 SLC11A1
20	reactive arthritis	9.6	TLR4 TLR2 SLC11A1
21	bubonic plague	9.6	TLR4 TLR2
22	vogt-koyanagi-harada disease	9.6	TLR4 TLR2 IRF8
23	pulmonary tuberculosis	9.6	TLR4 TLR2 SLC11A1
24	meningococcal meningitis	9.6	TLR4 TLR2
25	superficial basal cell carcinoma	9.5	TLR4 TLR2 MYD88
26	silo filler's disease	9.5	TLR4 TLR2 MYD88
27	myd88 deficiency	9.5	TLR4 TLR2 MYD88
28	irak4 deficiency	9.5	TLR4 TLR2 MYD88
29	anogenital venereal wart	9.5	TLR4 TLR2 MYD88
30	streptococcus pneumonia	9.5	TLR4 TLR2 MYD88
31	coccidiosis	9.5	TLR4 TLR2 MYD88
32	paracoccidioidomycosis	9.5	TLR4 TLR2 MYD88
33	bacterial sepsis	9.5	TLR4 TLR2 MYD88
34	bronchial disease	9.5	TLR4 TLR2 TBX21
35	plague	9.5	TLR4 TLR2 MYD88
36	urethritis	9.5	TLR4 TLR2
37	commensal bacterial infectious disease	9.5	TLR4 TLR2 MYD88
38	legionellosis	9.5	TLR4 TLR2 MYD88
39	autoimmune disease of central nervous system	9.4	TLR4 TLR2 TBX21
40	parasitic protozoa infectious disease	9.4	TLR4 TLR2 MYD88
41	toxoplasmosis	9.4	TLR4 TLR2 MYD88
42	lymphoma, mucosa-associated lymphoid type	9.4	TLR4 TLR2 MYD88
43	trypanosomiasis	9.4	TLR4 TLR2 MYD88
44	pertussis	9.4	TLR4 MYD88 IRF1
45	chagas disease	9.4	TLR4 TLR2 MYD88
46	pneumonic tularemia	9.3	TLR4 TLR2 MYD88 CLPB
47	splenic disease	9.3	TLR4 TLR2 SLC11A1 MYD88
48	salmonellosis	9.3	TLR4 TLR2 SLC11A1 MYD88
49	primary bacterial infectious disease	9.3	TLR4 TLR2 SLC11A1 MYD88
50	bacterial infectious disease	9.3	TLR4 TLR2 SLC11A1 MYD88

Graphical network of the top 20 diseases related to Gastrointestinal Tularemia:

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Symptoms & Phenotypes for Gastrointestinal Tularemia

MGI Mouse Phenotypes related to Gastrointestinal Tularemia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10	ARG1 BAZ2B CYBB IGLL5 IRF1 IRF8
2	homeostasis/metabolism	MP:0005376	9.9	ARG1 BAZ2B CYBB IRF1 IRF8 MAP3K5
3	immune system	MP:0005387	9.7	ARG1 BAZ2B CYBB IGLL5 IRF1 IRF8
4	neoplasm	MP:0002006	9.28	CYBB IRF1 IRF8 MAP3K5 MYD88 SLC11A1

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Drugs & Therapeutics for Gastrointestinal Tularemia

Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tularemia

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Genetic Tests for Gastrointestinal Tularemia

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Anatomical Context for Gastrointestinal Tularemia

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Publications for Gastrointestinal Tularemia

Articles related to Gastrointestinal Tularemia:

#	Title	Authors	PMID	Year
1	A combined enrichment and aptamer pulldown assay for Francisella tularensis detection in food and environmental matrices. ⁶¹	Lamont EA...Sreevatsan S	25536105	2014

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Genes for Gastrointestinal Tularemia

Genes related to Gastrointestinal Tularemia (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGSF3	Immunoglobulin Superfamily Member 3	Protein Coding	5.53	DISEASES inferred ¹⁵
2	PDP1	Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1	Protein Coding	5.1	DISEASES inferred ¹⁵
3	CLPB	Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit B	Protein Coding	5.07	DISEASES inferred ¹⁵
4	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	4.5	DISEASES inferred ¹⁵
5	IGLL5	Immunoglobulin Lambda Like Polypeptide 5	Protein Coding	4.44	DISEASES inferred ¹⁵
6	BAZ2B	Bromodomain Adjacent To Zinc Finger Domain 2B	Protein Coding	4.23	DISEASES inferred ¹⁵
7	IRF8	Interferon Regulatory Factor 8	Protein Coding	4.14	DISEASES inferred ¹⁵
8	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	3.91	DISEASES inferred ¹⁵
9	IRF1	Interferon Regulatory Factor 1	Protein Coding	3.75	DISEASES inferred ¹⁵
10	TLR2	Toll Like Receptor 2	Protein Coding	3.66	DISEASES inferred ¹⁵
11	TBX21	T-Box Transcription Factor 21	Protein Coding	3.55	DISEASES inferred ¹⁵
12	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	3.54	DISEASES inferred ¹⁵
13	ARG1	Arginase 1	Protein Coding	3.51	DISEASES inferred ¹⁵
14	TLR4	Toll Like Receptor 4	Protein Coding	3.47	DISEASES inferred ¹⁵
15	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Gastrointestinal Tularemia

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Expression for Gastrointestinal Tularemia

Search GEO for disease gene expression data for Gastrointestinal Tularemia.

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Pathways for Gastrointestinal Tularemia

Pathways related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²² NOD-like Receptor Signaling Pathways ⁶⁴	12.49	TLR4 TLR2 MYD88 IRF1
2	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.46	TLR4 TLR2 MYD88 MAP3K5
3	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.34	TLR4 TLR2 MYD88 MAP3K5
4	Antigen processing-Cross presentation ⁶⁵ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁵ Endosomal/Vacuolar pathway ⁶⁵ ER-Phagosome pathway ⁶⁵ Immune response Antigen presentation by MHC class I ²²	12.18	TLR4 TLR2 MYD88 CYBB
5	VEGF Pathway (Qiagen) ⁶³ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁵ VEGF Pathway ⁶³	12.13	TLR4 TLR2 MYD88 IRF8
6	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	11.95	TLR4 TLR2 MYD88 CYBB
7	Phagosome ³⁶	11.91	TLR4 TLR2 CYBB
8	NF-kappaB Signaling ⁴	11.87	TLR2 TBX21 MYD88 IRF8 IRF1
9	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	11.78	TLR4 TLR2 MYD88 IRF1
10	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	11.7	TLR4 TLR2 TBX21
11	Amoebiasis ³⁶	11.66	TLR4 TLR2 ARG1
12	Legionellosis ³⁶	11.34	TLR4 TLR2 MYD88
13	Malaria ³⁶	11.2	TLR4 TLR2 MYD88
14	IL1 and megakaryocytes in obesity ¹	10.97	TLR2 MYD88
15	Type II interferon signaling (IFNG) ¹	10.9	IRF8 IRF1 CYBB
16	NTHi-Induced Signaling ⁶³	10.85	TLR2 MYD88
17	Pertussis ³⁶	10.81	TLR4 MYD88 IRF8 IRF1

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GO Terms for Gastrointestinal Tularemia

Cellular components related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phagocytic vesicle membrane	GO:0030670	8.8	TLR2 SLC11A1 CYBB

Biological processes related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 41)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.14	TLR4 TLR2 TBX21 SLC11A1 IRF8 IRF1
2	positive regulation of gene expression	GO:0010628	10	TLR4 TLR2 TBX21 SLC11A1 MYD88
3	inflammatory response	GO:0006954	9.93	TLR4 TLR2 SLC11A1 MYD88 CYBB
4	cellular response to lipopolysaccharide	GO:0071222	9.88	TLR4 MYD88 IRF8 ARG1
5	immune system process	GO:0002376	9.87	TLR4 TLR2 MYD88 MAP3K5 IRF8 IRF1
6	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.86	TLR4 TLR2 MYD88
7	response to bacterium	GO:0009617	9.85	TLR4 SLC11A1 IRF8
8	cellular response to interferon-gamma	GO:0071346	9.82	TLR4 TLR2 IRF8
9	positive regulation of JNK cascade	GO:0046330	9.8	TLR4 MYD88 MAP3K5
10	cellular response to mechanical stimulus	GO:0071260	9.8	TLR4 MYD88 IRF1
11	type I interferon signaling pathway	GO:0060337	9.78	MYD88 IRF8 IRF1
12	positive regulation of interleukin-6 production	GO:0032755	9.77	TLR4 TLR2 MYD88
13	defense response to bacterium	GO:0042742	9.77	TLR4 SLC11A1 MYD88 IRF8 IGLL5
14	positive regulation of tumor necrosis factor production	GO:0032760	9.76	TLR4 TLR2 MYD88
15	positive regulation of interferon-gamma production	GO:0032729	9.74	TLR4 SLC11A1 IRF8
16	toll-like receptor signaling pathway	GO:0002224	9.72	TLR4 TLR2 MYD88
17	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.7	TLR4 TLR2 MYD88
18	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.69	TLR4 TLR2 MYD88
19	positive regulation of interleukin-10 production	GO:0032733	9.68	TLR4 TLR2
20	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.68	TLR4 MYD88
21	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	9.68	TLR4 CYBB
22	positive regulation of chemokine production	GO:0032722	9.67	TLR4 TLR2
23	positive regulation of interleukin-8 secretion	GO:2000484	9.67	TLR4 TLR2
24	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.66	TLR4 TLR2
25	respiratory burst	GO:0045730	9.65	SLC11A1 CYBB
26	macrophage activation	GO:0042116	9.65	TLR4 SLC11A1
27	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.64	TLR4 MYD88
28	I-kappaB phosphorylation	GO:0007252	9.64	TLR4 TLR2
29	cellular response to lipoteichoic acid	GO:0071223	9.63	TLR4 TLR2
30	positive regulation of interleukin-8 production	GO:0032757	9.63	TLR4 TLR2 MYD88
31	positive regulation of lymphocyte proliferation	GO:0050671	9.62	TLR4 MYD88
32	positive regulation of interleukin-12 biosynthetic process	GO:0045084	9.61	TLR4 IRF1
33	positive regulation of interferon-beta production	GO:0032728	9.61	TLR4 TLR2 IRF1
34	positive regulation of interleukin-12 production	GO:0032735	9.58	TLR4 TLR2 IRF8
35	negative regulation of T-helper 2 cell cytokine production	GO:2000552	9.56	TBX21 ARG1
36	phagocytosis	GO:0006909	9.56	TLR4 SLC11A1 MYD88 IRF8
37	response to lipopolysaccharide	GO:0032496	9.55	TLR4 TLR2 SLC11A1 MYD88 ARG1
38	positive regulation of matrix metallopeptidase secretion	GO:1904466	9.49	TLR4 TLR2
39	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO:1903974	9.48	TLR4 TLR2
40	defense response to protozoan	GO:0042832	9.26	SLC11A1 MYD88 IRF8 ARG1
41	innate immune response	GO:0045087	9.23	TLR4 TLR2 MYD88 MAP3K5 IRF1 IGLL5

Molecular functions related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	NAD+ nucleotidase, cyclic ADP-ribose generating	GO:0061809	9.26	TLR4 TLR2
2	NAD(P)+ nucleosidase activity	GO:0050135	9.16	TLR4 TLR2
3	Toll-like receptor binding	GO:0035325	8.96	TLR2 MYD88
4	lipopolysaccharide receptor activity	GO:0001875	8.62	TLR4 TLR2

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