MCID: GST018
MIFTS: 27

Gastrointestinal Tularemia

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Gastrointestinal Tularemia

MalaCards integrated aliases for Gastrointestinal Tularemia:

Name: Gastrointestinal Tularemia 12 15 71
Enteric Tularemia 12 71
Intestinal Tularaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14239
ICD9CM 34 021.1 021.8
UMLS 71 C0029835 C0152942 C0494039

Summaries for Gastrointestinal Tularemia

Disease Ontology : 12 A tularemia that results in formation of ulcerative lesions located in gastrointestinal tract. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom muscle aches, and has symptom vomiting.

MalaCards based summary : Gastrointestinal Tularemia, also known as enteric tularemia, is related to typhoidal tularemia and oculoglandular tularemia. An important gene associated with Gastrointestinal Tularemia is IGSF3 (Immunoglobulin Superfamily Member 3), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and NF-KappaB Family Pathway. Related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Gastrointestinal Tularemia

Diseases related to Gastrointestinal Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 typhoidal tularemia 10.4 PDP1 CLPB
2 oculoglandular tularemia 10.4 PDP1 CLPB
3 nontuberculous mycobacterial lung disease 10.2 TLR2 SLC11A1
4 human monocytic ehrlichiosis 9.9 TLR2 MYD88 CLPB
5 prosthetic joint infection 9.9 TLR4 TLR2
6 fungal keratitis 9.8 TLR4 TLR2
7 campylobacteriosis 9.8 TLR4 SLC11A1
8 neisseria meningitidis infection 9.8 TLR4 TLR2
9 spondylarthropathy 9.8 TLR4 TLR2
10 hereditary angioedema with normal c1inh 9.8 TLR4 TLR2
11 pneumonic plague 9.7 TLR4 TLR2
12 chlamydia pneumonia 9.7 TLR4 TLR2
13 combat disorder 9.7 TLR4 TLR2
14 suppurative otitis media 9.7 TLR4 TLR2
15 amebiasis 9.7 TLR4 TLR2 IGLL5
16 dental pulp disease 9.7 TLR4 TLR2
17 testicular disease 9.7 TLR4 TLR2 SLC11A1
18 leprosy 3 9.6 TLR4 TLR2 SLC11A1
19 visceral leishmaniasis 9.6 TLR4 TLR2 SLC11A1
20 reactive arthritis 9.6 TLR4 TLR2 SLC11A1
21 bubonic plague 9.6 TLR4 TLR2
22 vogt-koyanagi-harada disease 9.6 TLR4 TLR2 IRF8
23 pulmonary tuberculosis 9.6 TLR4 TLR2 SLC11A1
24 meningococcal meningitis 9.6 TLR4 TLR2
25 superficial basal cell carcinoma 9.5 TLR4 TLR2 MYD88
26 silo filler's disease 9.5 TLR4 TLR2 MYD88
27 myd88 deficiency 9.5 TLR4 TLR2 MYD88
28 irak4 deficiency 9.5 TLR4 TLR2 MYD88
29 anogenital venereal wart 9.5 TLR4 TLR2 MYD88
30 streptococcus pneumonia 9.5 TLR4 TLR2 MYD88
31 coccidiosis 9.5 TLR4 TLR2 MYD88
32 paracoccidioidomycosis 9.5 TLR4 TLR2 MYD88
33 bacterial sepsis 9.5 TLR4 TLR2 MYD88
34 bronchial disease 9.5 TLR4 TLR2 TBX21
35 plague 9.5 TLR4 TLR2 MYD88
36 urethritis 9.5 TLR4 TLR2
37 commensal bacterial infectious disease 9.5 TLR4 TLR2 MYD88
38 legionellosis 9.5 TLR4 TLR2 MYD88
39 autoimmune disease of central nervous system 9.4 TLR4 TLR2 TBX21
40 parasitic protozoa infectious disease 9.4 TLR4 TLR2 MYD88
41 toxoplasmosis 9.4 TLR4 TLR2 MYD88
42 lymphoma, mucosa-associated lymphoid type 9.4 TLR4 TLR2 MYD88
43 trypanosomiasis 9.4 TLR4 TLR2 MYD88
44 pertussis 9.4 TLR4 MYD88 IRF1
45 chagas disease 9.4 TLR4 TLR2 MYD88
46 pneumonic tularemia 9.3 TLR4 TLR2 MYD88 CLPB
47 splenic disease 9.3 TLR4 TLR2 SLC11A1 MYD88
48 salmonellosis 9.3 TLR4 TLR2 SLC11A1 MYD88
49 primary bacterial infectious disease 9.3 TLR4 TLR2 SLC11A1 MYD88
50 bacterial infectious disease 9.3 TLR4 TLR2 SLC11A1 MYD88

Graphical network of the top 20 diseases related to Gastrointestinal Tularemia:



Diseases related to Gastrointestinal Tularemia

Symptoms & Phenotypes for Gastrointestinal Tularemia

MGI Mouse Phenotypes related to Gastrointestinal Tularemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 ARG1 BAZ2B CYBB IGLL5 IRF1 IRF8
2 homeostasis/metabolism MP:0005376 9.9 ARG1 BAZ2B CYBB IRF1 IRF8 MAP3K5
3 immune system MP:0005387 9.7 ARG1 BAZ2B CYBB IGLL5 IRF1 IRF8
4 neoplasm MP:0002006 9.28 CYBB IRF1 IRF8 MAP3K5 MYD88 SLC11A1

Drugs & Therapeutics for Gastrointestinal Tularemia

Search Clinical Trials , NIH Clinical Center for Gastrointestinal Tularemia

Genetic Tests for Gastrointestinal Tularemia

Anatomical Context for Gastrointestinal Tularemia

Publications for Gastrointestinal Tularemia

Articles related to Gastrointestinal Tularemia:

# Title Authors PMID Year
1
A combined enrichment and aptamer pulldown assay for Francisella tularensis detection in food and environmental matrices. 61
25536105 2014

Variations for Gastrointestinal Tularemia

Expression for Gastrointestinal Tularemia

Search GEO for disease gene expression data for Gastrointestinal Tularemia.

Pathways for Gastrointestinal Tularemia

Pathways related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 TLR4 TLR2 MYD88 IRF1
2
Show member pathways
12.46 TLR4 TLR2 MYD88 MAP3K5
3
Show member pathways
12.34 TLR4 TLR2 MYD88 MAP3K5
4
Show member pathways
12.18 TLR4 TLR2 MYD88 CYBB
5
Show member pathways
12.13 TLR4 TLR2 MYD88 IRF8
6
Show member pathways
11.95 TLR4 TLR2 MYD88 CYBB
7 11.91 TLR4 TLR2 CYBB
8 11.87 TLR2 TBX21 MYD88 IRF8 IRF1
9
Show member pathways
11.78 TLR4 TLR2 MYD88 IRF1
10
Show member pathways
11.7 TLR4 TLR2 TBX21
11 11.66 TLR4 TLR2 ARG1
12 11.34 TLR4 TLR2 MYD88
13 11.2 TLR4 TLR2 MYD88
14 10.97 TLR2 MYD88
15 10.9 IRF8 IRF1 CYBB
16 10.85 TLR2 MYD88
17 10.81 TLR4 MYD88 IRF8 IRF1

GO Terms for Gastrointestinal Tularemia

Cellular components related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 8.8 TLR2 SLC11A1 CYBB

Biological processes related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 TLR4 TLR2 TBX21 SLC11A1 IRF8 IRF1
2 positive regulation of gene expression GO:0010628 10 TLR4 TLR2 TBX21 SLC11A1 MYD88
3 inflammatory response GO:0006954 9.93 TLR4 TLR2 SLC11A1 MYD88 CYBB
4 cellular response to lipopolysaccharide GO:0071222 9.88 TLR4 MYD88 IRF8 ARG1
5 immune system process GO:0002376 9.87 TLR4 TLR2 MYD88 MAP3K5 IRF8 IRF1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 TLR4 TLR2 MYD88
7 response to bacterium GO:0009617 9.85 TLR4 SLC11A1 IRF8
8 cellular response to interferon-gamma GO:0071346 9.82 TLR4 TLR2 IRF8
9 positive regulation of JNK cascade GO:0046330 9.8 TLR4 MYD88 MAP3K5
10 cellular response to mechanical stimulus GO:0071260 9.8 TLR4 MYD88 IRF1
11 type I interferon signaling pathway GO:0060337 9.78 MYD88 IRF8 IRF1
12 positive regulation of interleukin-6 production GO:0032755 9.77 TLR4 TLR2 MYD88
13 defense response to bacterium GO:0042742 9.77 TLR4 SLC11A1 MYD88 IRF8 IGLL5
14 positive regulation of tumor necrosis factor production GO:0032760 9.76 TLR4 TLR2 MYD88
15 positive regulation of interferon-gamma production GO:0032729 9.74 TLR4 SLC11A1 IRF8
16 toll-like receptor signaling pathway GO:0002224 9.72 TLR4 TLR2 MYD88
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 TLR4 TLR2 MYD88
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.69 TLR4 TLR2 MYD88
19 positive regulation of interleukin-10 production GO:0032733 9.68 TLR4 TLR2
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.68 TLR4 MYD88
21 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.68 TLR4 CYBB
22 positive regulation of chemokine production GO:0032722 9.67 TLR4 TLR2
23 positive regulation of interleukin-8 secretion GO:2000484 9.67 TLR4 TLR2
24 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.66 TLR4 TLR2
25 respiratory burst GO:0045730 9.65 SLC11A1 CYBB
26 macrophage activation GO:0042116 9.65 TLR4 SLC11A1
27 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.64 TLR4 MYD88
28 I-kappaB phosphorylation GO:0007252 9.64 TLR4 TLR2
29 cellular response to lipoteichoic acid GO:0071223 9.63 TLR4 TLR2
30 positive regulation of interleukin-8 production GO:0032757 9.63 TLR4 TLR2 MYD88
31 positive regulation of lymphocyte proliferation GO:0050671 9.62 TLR4 MYD88
32 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.61 TLR4 IRF1
33 positive regulation of interferon-beta production GO:0032728 9.61 TLR4 TLR2 IRF1
34 positive regulation of interleukin-12 production GO:0032735 9.58 TLR4 TLR2 IRF8
35 negative regulation of T-helper 2 cell cytokine production GO:2000552 9.56 TBX21 ARG1
36 phagocytosis GO:0006909 9.56 TLR4 SLC11A1 MYD88 IRF8
37 response to lipopolysaccharide GO:0032496 9.55 TLR4 TLR2 SLC11A1 MYD88 ARG1
38 positive regulation of matrix metallopeptidase secretion GO:1904466 9.49 TLR4 TLR2
39 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.48 TLR4 TLR2
40 defense response to protozoan GO:0042832 9.26 SLC11A1 MYD88 IRF8 ARG1
41 innate immune response GO:0045087 9.23 TLR4 TLR2 MYD88 MAP3K5 IRF1 IGLL5

Molecular functions related to Gastrointestinal Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.26 TLR4 TLR2
2 NAD(P)+ nucleosidase activity GO:0050135 9.16 TLR4 TLR2
3 Toll-like receptor binding GO:0035325 8.96 TLR2 MYD88
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR4 TLR2

Sources for Gastrointestinal Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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