GURDP
MCID: GST106
MIFTS: 64

Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets (GURDP)

Categories: Blood diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

MalaCards integrated aliases for Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

Name: Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets 56 73 6 17
Gurdp 56 73
Cytosolic Phospholipase-A2 Alpha Deficiency Associated Bleeding Disorder 58
Platelet Dysfunction Due to Cytosolic Phospholipase-A2 Alpha Deficiency 58
Phospholipase A2, Group Iv a, Deficiency of 29
Phospholipase A2, Group Iva, Deficiency of 56
Deficiency of Phospholipase A2, Group Iva 73
Pla2g4a-Related Platelet Dysfunction 58
Ulcer 43

Characteristics:

OMIM:

56
Inheritance:
autosomal recessive

Miscellaneous:
onset in first years of life


HPO:

31
gastrointestinal ulceration, recurrent, with dysfunctional platelets:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare gastroenterological diseases
Rare haematological diseases


Summaries for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

OMIM : 56 Recurrent gastrointestinal ulceration with dysfunctional platelets (GURDP) is an autosomal recessive disorder characterized by onset of severe gastrointestinal mucosal ulceration in early childhood. Affected individuals may have secondary iron deficiency anemia or malnourishment. Studies of platelet aggregation show a functional defect associated with decreased thromboxane-A2 production and decreased eicosanoid biosynthesis. The gastrointestinal disease is believed to result from decreased or absent production of prostaglandins that protect the gut mucosa (summary by Adler et al., 2008 and Faioni et al., 2014). (618372)

MalaCards based summary : Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets, also known as gurdp, is related to decubitus ulcer and peptic ulcer perforation. An important gene associated with Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets is PLA2G4A (Phospholipase A2 Group IVA), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. The drugs Acetylcysteine and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and colon, and related phenotypes are iron deficiency anemia and gastric ulcer

UniProtKB/Swiss-Prot : 73 Gastrointestinal ulceration, recurrent, with dysfunctional platelets: An autosomal recessive disorder characterized by recurrent gastrointestinal mucosal ulcers, gastrointestinal bleeding, chronic anemia, iron deficiency, and abdominal pain. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis.

Related Diseases for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Diseases related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2483)
# Related Disease Score Top Affiliating Genes
1 decubitus ulcer 33.7 PDGFB FGF2
2 peptic ulcer perforation 33.5 S100A8 HRH2 GAST
3 duodenal ulcer 33.4 S100A8 HRH2 GAST EGF
4 active peptic ulcer disease 33.1 PTGS2 PTGS1 HRH2
5 peptic ulcer disease 33.0 S100A8 PTGS2 PTGS1 HRH2 GAST
6 chronic ulcer of skin 32.9 PDGFB FGF2 EGF
7 helicobacter pylori infection 32.5 S100A8 GAST
8 zollinger-ellison syndrome 32.2 HRH2 GAST EGF
9 stomach disease 31.4 PTGS2 PTGS1 HRH2
10 gastric ulcer 31.3 S100A8 PTGS2 PTGS1 HRH2 GAST FGF2
11 gastritis 31.2 S100A8 PTGS2 PTGS1 HRH2 GAST
12 duodenitis 31.2 S100A8 GAST
13 gastroduodenitis 31.0 S100A8 GAST
14 hernia, hiatus 30.8 HRH2 GAST
15 inflammatory bowel disease 30.6 S100A8 PTGS2 PTGS1 FGF2 EGF
16 microinvasive gastric cancer 30.6 S100A8 GAST
17 hydrops, lactic acidosis, and sideroblastic anemia 30.4 PTGS2 PTGS1
18 esophagitis 30.3 PTGS2 HRH2 GAST EGF
19 bile reflux 30.2 S100A8 PTGS2 GAST
20 peptic esophagitis 30.2 S100A8 PTGS2 HRH2 GAST
21 constipation 30.1 PTGS2 PTGS1 GAST
22 atrophic gastritis 30.0 S100A8 PTGS2 GAST EGF
23 gastric cancer 29.9 S100A8 PTGS2 HRH2 GAST FGF2 EGF
24 urticaria 29.8 PTGS2 PTGS1 HRH2
25 laryngitis 29.8 HRH2 FGF2
26 squamous cell carcinoma, head and neck 29.7 PTGS2 PTGS1 FGF2 EGF
27 gastric adenocarcinoma 29.4 S100A8 PTGS2 GAST EGF
28 duodenum disease 29.2 S100A8 GAST
29 aspirin resistance 29.1 PTGS2 PTGS1
30 autoimmune gastritis 29.0 GAST EGF
31 dry eye syndrome 29.0 S100A8 FGF2 EGF
32 gastroesophageal reflux 28.8 S100A8 PTGS2 PTGS1 HRH2 GAST EGF
33 oral submucous fibrosis 28.4 PTGS2 FGF2
34 pancreatic adenocarcinoma 28.1 PTGS2 GAST FGF2 EGF
35 glioma 28.0 PDGFB FGF2 EGF
36 medulloblastoma 27.4 PTGS2 PDGFB FGF2 EGF
37 ulcerative colitis 12.9
38 buruli ulcer 12.7
39 ulcer of lower limbs 12.7
40 corneal ulcer 12.6
41 gastrojejunal ulcer 12.6
42 necrotizing ulcerative gingivitis 12.6
43 ulcerative proctitis 12.6
44 mooren's ulcer 12.5
45 ulceration of vulva 12.5
46 umbilical cord ulceration and intestinal atresia 12.5
47 mucocutaneous ulceration, chronic 12.5
48 central corneal ulcer 12.5
49 perforated corneal ulcer 12.4
50 marginal corneal ulcer 12.4

Graphical network of the top 20 diseases related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:



Diseases related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets

Symptoms & Phenotypes for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Human phenotypes related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

31 (show all 6)
# Description HPO Frequency HPO Source Accession
1 iron deficiency anemia 31 HP:0001891
2 gastric ulcer 31 HP:0002592
3 esophageal ulceration 31 HP:0004791
4 duodenal ulcer 31 HP:0002588
5 impaired platelet aggregation 31 HP:0003540
6 decreased serum thromboxane b2 31 HP:0032244

Symptoms via clinical synopsis from OMIM:

56
Abdomen Gastrointestinal:
fistulas
mucosal ulceration, recurrent
duodenal ulcers
small bowel ulcers
esophageal ulcers

Laboratory Abnormalities:
decreased serum eicosanoids
decreased thromboxane-b2 (txb2)
decreased 12-hete

Hematology:
impaired platelet aggregation due to impaired thromboxane-a2 production
iron deficiency anemia, secondary

Clinical features from OMIM:

618372

MGI Mouse Phenotypes related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 EGF GAST HRH2 PLA2G4A PTGS1 PTGS2
2 endocrine/exocrine gland MP:0005379 9.73 EGF GAST HRH2 PLA2G4A PTGS1 PTGS2
3 muscle MP:0005369 9.55 FGF2 PDGFB PLA2G4A PTGS1 PTGS2
4 neoplasm MP:0002006 9.35 FGF2 GAST PLA2G4A PTGS1 PTGS2
5 reproductive system MP:0005389 9.1 EGF FGF2 PDGFB PLA2G4A PTGS1 PTGS2

Drugs & Therapeutics for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Drugs for Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 777)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Acyclovir Approved Phase 4 59277-89-3 2022
3
Saxagliptin Approved Phase 4 361442-04-8 11243969
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Insulin aspart Approved Phase 4 116094-23-6 16132418
7
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
8
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
9
Enalaprilat Approved Phase 4 76420-72-9 6917719
10
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
11
Docosanol Approved, Investigational Phase 4 661-19-8, 30303-65-2 12620
12
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
13
Ondansetron Approved Phase 4 99614-02-5 4595
14
Capsaicin Approved Phase 4 404-86-4 1548943
15
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
16
Nitric Oxide Approved Phase 4 10102-43-9 145068
17
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
18
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
19
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
20 Bemiparin Approved, Investigational Phase 4 91449-79-5
21
Dalteparin Approved Phase 4 9005-49-6
22
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
23
Ibuprofen Approved Phase 4 15687-27-1 3672
24
Potassium citrate Approved, Investigational, Vet_approved Phase 4
25
Atorvastatin Approved Phase 4 134523-00-5 60823
26
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
27
Metformin Approved Phase 4 657-24-9 14219 4091
28
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
29
Acetaminophen Approved Phase 4 103-90-2 1983
30
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
31
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
32
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
33
Mercaptopurine Approved Phase 4 50-44-2 667490
34
Sucralfate Approved Phase 4 54182-58-0
35
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
36
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
37
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
38
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
39
Remifentanil Approved Phase 4 132875-61-7 60815
40
Phylloquinone Approved, Investigational Phase 4 84-80-0
41
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
42
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
43
Ticagrelor Approved Phase 4 274693-27-5 9871419
44
Bisoprolol Approved Phase 4 66722-44-9 2405
45
Misoprostol Approved Phase 4 59122-46-2 5282381
46
Infliximab Approved Phase 4 170277-31-3
47
Caffeine Approved Phase 4 58-08-2 2519
48
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
49
Nicotine Approved Phase 4 54-11-5 942 89594
50
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821

Interventional clinical trials:

(show top 50) (show all 2749)
# Name Status NCT ID Phase Drugs
1 An Open Label, Multi Center, Post Marketing Study Of Pain And Quality Of Life Outcomes In Subjects With a Single Painful Venous Leg Ulcer Treated With Apligraf® Unknown status NCT02011724 Phase 4
2 Helicobacter Pylori Eradication Therapy on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection of Gastric Neoplastic Lesions: a Multicenter, Randomized, Double Blind, and Placebo Controlled Trial Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
3 Evaluation of the Efficacy of Concomitant Therapy for Eradication of Helicobacter Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
4 Phase IV Study Comparing Helicobacter Pylori Empiric Eradication With Test-Guided Treatment in Patients With Peptic Ulcer Bleeding Unknown status NCT00687336 Phase 4
5 Efficacy of an Ecabet Sodium and Proton Pump Inhibitor (PPI) Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection: A Prospective Randomized Controlled Trial Unknown status NCT01308177 Phase 4 Ecabet
6 A Prospective Single Blind Randomised Controlled Study to Compare the Outcomes of Patients With Diabetes and Clinically Non-infected Neuro-ischaemic and Neuropathic Foot Ulcers Treated With and Without Oral Antibiotics. Unknown status NCT01418456 Phase 4 antibiotics
7 A Controlled Clinical Trial of Dipeptidyl Peptidase 4 Inhibition Facilitate Healing of Diabetic Ulcers Unknown status NCT02742233 Phase 4 saxagliptin;placebo
8 Post-Market Clinical Evaluation of the Spiracur SNaP Wound Care System Unknown status NCT01113658 Phase 4
9 Effects of Ilaprazole 20mg on Ulcer Healing Rate and Prevention of Gastrointestinal Bleeding in the Patients Undergone Endoscopic Submucosal Dissection(ESD) for Gastric Adenoma or Early Gastric Cancer. Unknown status NCT02638584 Phase 4 Ilaprazole;Rabeprazole
10 Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD? Unknown status NCT01621451 Phase 4 aspirin and/or clopidogrel;aspirin and/or clopidogrel
11 Compare Gastric Acid Suppression of Esomeprazole by Oral or Intravenous Administration - A Randomized Trial Unknown status NCT00471029 Phase 4 esomeprazole
12 Olive Oil's Cream Effectiveness in Prevention of Pressure Ulcers in Immobilized Patients in Primary Care.A Cluster Randomized Clinical Trial. Unknown status NCT01595347 Phase 4 Hyper-oxigenated fatty acid
13 A Comparison of Total Contact Casting (TCC-EZ) Using Human Amnion Allograft (AmnioExcel) Versus Total Contact Casting (TCC-EZ) and Standard Wound Care in Treating Diabetic Foot Ulcers (TAD) Unknown status NCT02344329 Phase 4
14 Oral vs Intravenous Proton Pump Inhibitor(PPI) in Patients With Peptic Ulcer Bleeding After Successful Endoscopic Therapy- a Prospective Randomized Comparative Trial Unknown status NCT01123031 Phase 4 lansoprazole;esomeprazole
15 A Randomised Controlled Clinical Trial Comparing the Effectiveness of Bandaging Compared to the Juxta-CuresTM Device in the Management of People With Venous Ulceration: Feasibility Study Unknown status NCT02790593 Phase 4
16 PREDICT UC: Optimising Infliximab Induction Therapy for Acute Severe Ulcerative Colitis - A Randomised Controlled Trial Unknown status NCT02770040 Phase 4 Infliximab
17 Phase IV Prospective, Multi-Center, Randomized, Single-Blind, Active and Standard Care-Controlled Study of DermaPure™ in Patients With "Hard to Heal" Chronic, Neuropathic Diabetic Foot Ulcers With Crossover Design for Standard Care Arm Unknown status NCT02081352 Phase 4
18 A 12-week, Single Site, Randomized Controlled Trial to Compare the Efficacy of Quantum NPWT With and Without Simultaneous Irrigation Versus Standard of Care on Reduction of the Volume of Stage III/IV Pressure Ulcers. Unknown status NCT01734109 Phase 4
19 The Effect of Insulin Infusion on Metabolic Control and Inflammation in Diabetic Patients During Cardio-vascular Intervention and/or Treatment for Acute Foot Ulcer Infection. Unknown status NCT00700154 Phase 4
20 Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis: An Open-label,Randomized,Phase IV Clinical Trial Unknown status NCT02962245 Phase 4 berberine;regular treatment
21 Comparison of the Efficacy of Sequential Therapy and Bismuth Quadruple Therapy in the First Line and Second Line Therapy for Helicobacter Pylori Infection- A Multi-center Randomized Trial Unknown status NCT03156855 Phase 4 14-day sequential therapy;Bismuth quadruple therapy
22 Helicobacter Pylori Eradication Rates of Concomitant Therapy and Tailored Therapy Based on 23S Ribosomal RNA Point Mutations Associated With Clarithromycin Resistance: A Multicenter Prospective Randomized Study Unknown status NCT03130452 Phase 4 Lansoprazole 30mg;Amoxicillin 1.0g Tab;Clarithromycin 500mg;Metronidazole 500 mg
23 Banding Ligation With Carvedilol vs. Carvedilol for the Prevention of First Bleeding in Cirrhotics With Moderate Varices Unknown status NCT01383044 Phase 4 carvedilol
24 A Double Blind Study Comparing Low Dose and High Dose IV Esomeprazole After Successful Endoscopic Therapy in Patients With Peptic Ulcer Bleeding Unknown status NCT01275937 Phase 4 Esomeprazole;esomeprazole
25 Esomeprazole or Famotidine in the Management of Aspirin Related Non-ulcer Dyspepsia - a Double Blind Randomized Control Study Unknown status NCT00978159 Phase 4 esomeprazole;Famotidine
26 Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Type 2 Diabetic Mellitus Foot Ulcers: A Prospective Randomized Controlled Study Unknown status NCT02816749 Phase 4
27 Aspirin and the Antiproteinuric Effect of Enalapril in Microalbuminuric Type 2 Diabetes Mellitus Patients: a Randomized, Double-Blind, Placebo-Controlled Study Unknown status NCT00427271 Phase 4 aspirin
28 Pilot Study to Evaluate the Efficacy of Golimumab for Induction and Maintenance of Clinical and Endoscopic Remission in Patients With Steroid-dependent Ulcerative Colitis Unknown status NCT02412085 Phase 4 Golimumab
29 Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral Tubing Unknown status NCT02998112 Phase 4 fecal microbiota transplantation;Saline
30 Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
31 A Randomized, Double-blind Study Investigating the Efficacy and Safety of Mesalazine With Hydrocortisone Sodium Succinate (100mg QD) Enema for 4-Week Treatment in Patients With Ulcerative Colitis (UC) Unknown status NCT03110198 Phase 4 Mesalazine;hydrocortisone sodium succinate;Mesalazine with hydrocortisone sodium succinate
32 Combination Corticosteroids + 5-aminosalicylic Acids Compared to Corticosteroids Alone in the Treatment of Moderate-severe Active Ulcerative Colitis. Unknown status NCT01941589 Phase 4 oral 5-ASA+/-topical 5-ASA+IV corticosteroids / PO Methylprednisolone;corticosteroids only
33 The Safety, Efficacy and Convenience of Use of the Natural Agent "Superlysin Gel" as Treatment for Herpes Labialis in Comparison to Acyclovir 5% and Docozanole 10%. Unknown status NCT00467662 Phase 4 Acyclovir 5%;Docosanol 10%
34 Probiotic for the Restoration of Intestinal Permeability and Reduction of Intestinal Inflammation in Active Ulcerative Colitis: A Double Blind Randomized Placebo Controlled Trial Unknown status NCT01479660 Phase 4 Probiotic
35 Personalised Medicine: a Break Through Approach for Early Determination of Anti Tumor Necrosis Factor (TNF) Responders and Non Responders Among Patients With Ulcerative Colitis in a Prospective Study With Golimumab (Simponi) Unknown status NCT02186886 Phase 4 Golimumab
36 Prevention of Esophageal Variceal Rebleeding Unknown status NCT00863837 Phase 4 terlipressin (vasoconstrictor);pantoloc (proton pump inhibitor)
37 Phase 4, Prospective, Randomized Study Comparing 14-day Non-bismuth Quadruple "Hybrid" and "Concomitant" Therapies for Helicobacter Pylori Eradication in Settings With High Clarithromycin Resistance Unknown status NCT01464060 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
38 Comparison of Triple Therapy Regimens Effectiveness Over 10 Days and 14 Days in Eradication of Helicobacter Pylori Infection: Double Blind Randomized Clinical Trial Unknown status NCT03134378 Phase 4 Rabeprazole Sodium 20mg;Clarithromycin 500mg;Amoxicillin 500 Mg
39 "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" Unknown status NCT02028234 Phase 4 Pantoprazole,;Omeprazole
40 Randomized Controlled Trial Comparing the Efficacy of Polyethylene Glycol Alone and Polyethylene Glycol Combined With Topical Diltiazem in Treating Anal fissure in Children Unknown status NCT02419534 Phase 4 Polyethylene glycol;Polyethylene glycol with Diltiazem
41 Comparison of the Efficacy of Triple Therapy With or Without Acetylcysteine in the First Line of Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
42 Optimal Anti-Platelet Treatment for Patients With Stent IMplantation And Clopidogrel Low Response: OPTIMAL Study Unknown status NCT01955200 Phase 4 Ticagrelor;Clopidogrel;Cilostazol;Clopidogrel;Clopidogrel
43 The Impact of Early Feeding Following Ligation of the Acute Bleeding Varices Unknown status NCT01287702 Phase 4
44 Comparative Study of Antiemetic Effect of Ramosetron With Combination of Ondansetron and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy Unknown status NCT02803788 Phase 4 ramosetron, ondansetron, dexamethasone
45 Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia: a Multi-national, Randomised, Double-blind, Placebo-controlled Study Unknown status NCT02134405 Phase 4 Rebamipide;Placebo (for Esomeprazole);Esomeprazole
46 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
47 Comparison of the Incidence of Ventilator Associated Pneumonia in Patients Intubated With the Taper Guard Endotracheal Tube Versus a Normal Endotracheal Tube Unknown status NCT01501227 Phase 4
48 Prospective, Randomized Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Plus Epinephrine Injection in Nonvariceal Upper Gastrointestinal Bleeding Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
49 A Post-Marketing Clinical Study of Rebamipide to Investigate the Gastric Ulcer Healing Effect of Continued Dosing Following Helicobacter Pylori Eradication Therapy Completed NCT00233389 Phase 4 Rebamipide
50 A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers Completed NCT00235209 Phase 4

Search NIH Clinical Center for Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets

Cochrane evidence based reviews: ulcer

Genetic Tests for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Genetic tests related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

# Genetic test Affiliating Genes
1 Phospholipase A2, Group Iv a, Deficiency of 29

Anatomical Context for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

MalaCards organs/tissues related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

40
Skin, Testes, Colon, Bone, Liver, Spinal Cord, Tongue

Publications for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Articles related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

(show top 50) (show all 30309)
# Title Authors PMID Year
1
Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency. 56 6
25102815 2014
2
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. 56 6
23268370 2014
3
Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. 56 6
18451993 2008
4
DNA methylation patterns of ulcer-healing genes associated with the normal gastric mucosa of gastric cancers. 54 61
20191040 2010
5
[Effect of yiqi huoxue formula on healing quality and recurrence rate of peptic ulcer]. 54 61
20214327 2009
6
vacA genotypes in Helicobacter pylori strains isolated from patients with and without duodenal ulcer in Bahrain. 54 61
20107966 2009
7
Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer. 54 61
19638336 2009
8
[Effect of transcranial electrostimulation on clinical and laboratory characteristics in patients with gastric ulcer]. 54 61
19708562 2009
9
[Six cases with Behcet's disease presenting cervical ulcer]. 54 61
19570421 2009
10
Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. 54 61
18008231 2007
11
[Comparison of the burn wound and diabetic ulcer wound]. 54 61
18396758 2007
12
[Genetic polymorphism of COX-1 gene and NSAID-induced ulcer]. 54 61
17926541 2007
13
The use of recombinant human epidermal growth factor to promote healing for chronic radiation ulcer. 54 61
17924878 2007
14
[Clinical study on effect of Jianwei Yuyang Granule in treating patients with gastric ulcer]. 54 61
17717918 2007
15
Helicobacter pylori cagA and iceA genotypes status and risk of peptic ulcer in Saudi patients. 54 61
17334464 2007
16
Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial. 54 61
17258718 2007
17
Primer: managing NSAID-induced ulcer complications--balancing gastrointestinal and cardiovascular risks. 54 61
17008926 2006
18
Regulated spatial distribution of cyclooxygenases and lipoxygenases in Crohn's ulcer. 54 61
16951496 2006
19
Recent advances in gastric ulcer therapeutics. 54 61
16188503 2005
20
Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications. 54 61
16271912 2005
21
Cellular and molecular mechanisms of gastrointestinal ulcer healing. 54 61
16184417 2005
22
Prostaglandins and ulcer healing. 54 61
16247187 2005
23
An overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research. 54 61
16079471 2005
24
Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries. 54 61
15866209 2005
25
Keratinocyte and dermal vascular endothelial cell capacities remain unimpaired in the margin of chronic venous ulcer. 54 61
15565301 2005
26
Distribution of vacA alleles and cagA status of Helicobacter pylori in peptic ulcer disease and non-ulcer dyspepsia. 54 61
15606640 2004
27
Three cases of ischemic ulcer due to arteriosclerosis obliterans responding to basic fibroblast growth factor spray. 54 61
15372302 2004
28
Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. 54 61
15188176 2004
29
[Are COX-2 inhibitors truly able to prevent NSAIDs-associated ulcer?]. 54 61
15038104 2004
30
Have COX-2 inhibitors influenced the co-prescription of anti-ulcer drugs with NSAIDs? 54 61
14998430 2004
31
Biphasic role of platelet-activating factor in oral mucosal ulcer healing. 54 61
14609204 2003
32
Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey. 54 61
12679943 2003
33
A therapy-resistant chronic leg ulcer treated successfully with topical basic fibroblast growth factor. 54 61
12760319 2003
34
Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. 54 61
12678329 2003
35
cagA and vacA in strains of Helicobacter pylori from ulcer and non-ulcerative dyspepsia patients. 54 61
12223115 2002
36
Antiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats. 54 61
12217640 2002
37
Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing. 54 61
11832460 2002
38
[Role of stress in the etiopathogenesis of duodenal ulcer in young patients]. 54 61
12619573 2002
39
Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats. 54 61
11736732 2001
40
Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. 54 61
11511570 2001
41
Role of growth factors and their receptors in gastric ulcer healing. 54 61
11376497 2001
42
Overexpression of co-stimulatory molecules in peripheral mononuclear cells of Helicobacter pylori-positive peptic ulcer patients: possible difference in host responsiveness compared with non-ulcer patients. 54 61
11204803 2001
43
Up-regulation of cyclooxygenase-1 and -2 in human gastric ulcer. 54 61
11136275 2001
44
Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs. 54 61
11142556 2000
45
The nitric oxide connection: hyperbaric oxygen therapy, becaplermin, and diabetic ulcer management. 54 61
11075012 2000
46
Reduced risk of upper gastrointestinal ulcer complications with celecoxib, a novel COX-2 inhibitor. 54 61
10925968 2000
47
Growth factors in ulcer healing: lessons from recent studies. 54 61
10791686 2000
48
The role of gastrin in ulcer pathogenesis. 54 61
10749086 2000
49
[Acid-base balance in ulcer patients]. 54 61
10881506 2000
50
Use of proton-pump inhibitors in complicated ulcer disease and upper gastrointestinal tract bleeding. 54 61
10597118 1999

Variations for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

ClinVar genetic disease variations for Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PLA2G4A NM_024420.2(PLA2G4A):c.331T>C (p.Ser111Pro)SNV Pathogenic 9079 rs121434634 1:186863296-186863296 1:186894164-186894164
2 PLA2G4A NM_024420.2(PLA2G4A):c.1454G>A (p.Arg485His)SNV Pathogenic 9080 rs121434635 1:186925351-186925351 1:186956219-186956219
3 PLA2G4A NM_024420.2(PLA2G4A):c.1723G>C (p.Asp575His)SNV Pathogenic 624621 rs1557895416 1:186934684-186934684 1:186965552-186965552
4 PLA2G4A NM_024420.2(PLA2G4A):c.2118+4_2118+7deldeletion Pathogenic 624622 rs1557901999 1:186948605-186948608 1:186979473-186979476
5 PLA2G4A NM_024420.2(PLA2G4A):c.494dup (p.Arg166fs)duplication Pathogenic 807464 1:186880456-186880457 1:186911324-186911325

UniProtKB/Swiss-Prot genetic disease variations for Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets:

73
# Symbol AA change Variation ID SNP ID
1 PLA2G4A p.Asp575His VAR_082091

Expression for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Search GEO for disease gene expression data for Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets.

Pathways for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Pathways related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 PLA2G4A PDGFB FGF2 EGF
2
Show member pathways
12.83 PTGS2 PDGFB FGF2 EGF
3
Show member pathways
12.77 PTGS2 PTGS1 PLA2G4A PDGFB EGF
4
Show member pathways
12.76 PTGS2 PDGFB FGF2 EGF
5 12.61 PTGS2 PDGFB FGF2 EGF
6 12.52 PLA2G4A PDGFB FGF2 EGF
7
Show member pathways
12.46 PLA2G4A PDGFB FGF2 EGF
8
Show member pathways
12.2 PLA2G4A GAST EGF
9
Show member pathways
12.2 PLA2G4A PDGFB EGF
10
Show member pathways
12.2 PTGS2 PTGS1 PLA2G4A
11
Show member pathways
12.12 PTGS2 HRH2 EGF
12
Show member pathways
11.96 PTGS2 PTGS1 PLA2G4A
13
Show member pathways
11.91 PLA2G4A PDGFB EGF
14 11.82 PDGFB FGF2 EGF
15
Show member pathways
11.74 PTGS2 PTGS1 PLA2G4A
16 11.71 PTGS2 PTGS1 PLA2G4A
17 11.51 PDGFB FGF2 EGF
18 11.34 PTGS2 PLA2G4A
19 11.34 PDGFB FGF2 EGF
20 11.26 PTGS2 PTGS1 PLA2G4A
21 11.17 PTGS2 PLA2G4A
22 11.11 PDGFB FGF2 EGF
23
Show member pathways
11.04 PTGS2 PTGS1
24 10.99 PTGS2 PTGS1
25 10.98 PDGFB FGF2
26 10.97 PDGFB FGF2 EGF
27 10.95 PTGS2 PTGS1
28 10.85 PTGS2 PTGS1
29 10.71 PTGS2 PTGS1
30 10.61 PTGS2 PTGS1 PLA2G4A
31 10.25 PTGS2 PTGS1 PLA2G4A
32 10.1 HRH2 GAST

GO Terms for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

Biological processes related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.72 PDGFB FGF2 EGF
2 angiogenesis GO:0001525 9.71 PTGS2 FGF2 EGF
3 positive regulation of cell proliferation GO:0008284 9.71 PTGS2 PDGFB FGF2 EGF
4 regulation of cell proliferation GO:0042127 9.65 PTGS2 PTGS1 PLA2G4A
5 positive regulation of protein kinase B signaling GO:0051897 9.61 PDGFB FGF2 EGF
6 positive chemotaxis GO:0050918 9.6 PDGFB FGF2
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.59 PDGFB FGF2
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 PDGFB FGF2
9 positive regulation of cell division GO:0051781 9.58 PDGFB FGF2
10 positive regulation of protein tyrosine kinase activity GO:0061098 9.57 PDGFB EGF
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.56 PTGS2 FGF2
12 positive regulation of vasoconstriction GO:0045907 9.52 PTGS2 HRH2
13 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.51 PDGFB FGF2
14 positive regulation of mitotic nuclear division GO:0045840 9.49 PDGFB EGF
15 prostaglandin metabolic process GO:0006693 9.46 PTGS2 PTGS1
16 prostaglandin biosynthetic process GO:0001516 9.37 PTGS2 PTGS1
17 positive regulation of DNA biosynthetic process GO:2000573 9.32 PDGFB FGF2
18 cyclooxygenase pathway GO:0019371 9.26 PTGS2 PTGS1
19 paracrine signaling GO:0038001 9.16 PDGFB FGF2
20 positive regulation of MAP kinase activity GO:0043406 9.13 PDGFB FGF2 EGF
21 positive regulation of hyaluronan biosynthetic process GO:1900127 8.62 PDGFB EGF

Molecular functions related to Gastrointestinal Ulceration, Recurrent, with Dysfunctional Platelets according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.26 PDGFB FGF2
2 peroxidase activity GO:0004601 9.16 PTGS2 PTGS1
3 growth factor activity GO:0008083 9.13 PDGFB FGF2 EGF
4 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS2 PTGS1

Sources for Gastrointestinal Ulceration, Recurrent, with Dysfunctional...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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