MCID: GST013
MIFTS: 41

Gastrojejunal Ulcer

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastrojejunal Ulcer

MalaCards integrated aliases for Gastrojejunal Ulcer:

Name: Gastrojejunal Ulcer 12 15 32
Chronic Gastrojejunal Ulcer Without Mention of Hemorrhage or Perforation, Without Mention of Obstruction 12
Acute Gastrojejunal Ulcer Without Mention of Hemorrhage or Perforation, Without Mention of Obstruction 12
Chronic Gastrojejunal Ulcer Without Hemorrhage, Without Perforation and Without Obstruction 12
Acute Gastrojejunal Ulcer Without Hemorrhage, Without Perforation and Without Obstruction 12
Acute Gastrojejunal Ulcer with Hemorrhage, with Perforation and with Obstruction 12
Acute Gastrojejunal Ulcer with Hemorrhage and Perforation, with Obstruction 12
Chronic Gastrojejunal Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastrojejunal Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastrojejunal Ulcer with Perforation, with Obstruction 12
Acute Gastrojejunal Ulcer, with Hemorrhage, with Obstruction 12
Acute Gastrojejunal Ulcer with Perforation and Obstruction 12
Acute Gastrojejunal Ulcer with Hemorrhage and Obstruction 12
Acute Gastrojejunal Ulcer with Hemorrhage and Perforation 12
Acute Gastrojejunal Ulcer with Perforation 12
Acute Gastrojejunal Ulcer with Hemorrhage 12
Marginal Ulcer 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10927
ICD9CM 34 534.0
SNOMED-CT 67 196709002
ICD10 32 K28 K28.0
UMLS 70 C0024799 C0156042

Summaries for Gastrojejunal Ulcer

MalaCards based summary : Gastrojejunal Ulcer, also known as chronic gastrojejunal ulcer without mention of hemorrhage or perforation, without mention of obstruction, is related to zollinger-ellison syndrome and gastrointestinal ulceration, recurrent, with dysfunctional platelets. An important gene associated with Gastrojejunal Ulcer is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Serotonergic synapse and Linoleic acid metabolism. The drugs Omeprazole and Histamine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, spleen and heart, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Gastrojejunal Ulcer

Diseases related to Gastrojejunal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 zollinger-ellison syndrome 30.2 NTS ATP4A ATP12A
2 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.8
3 angiodysplasia 10.4 ATP4A ATP12A
4 vagus nerve disease 10.4 ATP4A ATP12A
5 necrotizing gastritis 10.4 ATP4A ATP12A
6 scalp dermatosis 10.4 ATP4A ATP12A
7 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
8 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
9 lingual goiter 10.4 ATP4A ATP12A
10 displacement of cardia through esophageal hiatus 10.4 ATP4A ATP12A
11 bacterial esophagitis 10.4 ATP4A ATP12A
12 cascade stomach 10.4 ATP4A ATP12A
13 benzylpenicillin allergy 10.4 ATP4A ATP12A
14 median arcuate ligament syndrome 10.4 ATP4A ATP12A
15 afferent loop syndrome 10.4 ATP4A ATP12A
16 cervix erosion 10.4 ATP4A ATP12A
17 granulomatous gastritis 10.4 ATP4A ATP12A
18 laryngeal tuberculosis 10.4 ATP4A ATP12A
19 fungal esophagitis 10.4 ATP4A ATP12A
20 esophagus melanoma 10.4 ATP4A ATP12A
21 gastric gastrinoma 10.4 ATP4A ATP12A
22 superior mesenteric artery syndrome 10.4 ATP4A ATP12A
23 pneumatosis cystoides intestinalis 10.4 ATP4A ATP12A
24 chronic laryngitis 10.4 ATP4A ATP12A
25 laryngitis 10.4 ATP4A ATP12A
26 peptic ulcer perforation 10.4 ATP4A ATP12A
27 viral laryngitis 10.4 ATP4A ATP12A
28 gastroduodenal crohn's disease 10.4 ATP4A ATP12A
29 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 ATP4A ATP12A
30 rumination disorder 10.4 ATP4A ATP12A
31 acute laryngitis 10.4 ATP4A ATP12A
32 gastroduodenitis 10.4 ATP4A ATP12A
33 chronic intestinal vascular insufficiency 10.4 ATP4A ATP12A
34 barbiturate abuse 10.4 ATP4A ATP12A
35 duodenal gastrinoma 10.4 ATP4A ATP12A
36 gastric dilatation 10.4 ATP4A ATP12A
37 blind loop syndrome 10.4 ATP4A ATP12A
38 polycystic echinococcosis 10.4 ATP4A ATP12A
39 diclofenac allergy 10.4 ATP4A ATP12A
40 lymphocytic gastritis 10.4 ATP4A ATP12A
41 x-linked chondrodysplasia punctata 1 10.4 ATP4A ATP12A
42 pancreatic gastrinoma 10.3 ATP4A ATP12A
43 duodenal obstruction 10.3 ATP4A ATP12A
44 epidermolysis bullosa simplex, ogna type 10.3 ATP4A ATP12A
45 aspiration pneumonitis 10.3 ATP4A ATP12A
46 gastric antral vascular ectasia 10.3 ATP4A ATP12A
47 functional diarrhea 10.3 ATP4A ATP12A
48 squamous papillomatosis 10.3 ATP4A ATP12A
49 esophageal tuberculosis 10.3 ATP4A ATP12A
50 eosinophilic gastritis 10.3 ATP4A ATP12A

Graphical network of the top 20 diseases related to Gastrojejunal Ulcer:



Diseases related to Gastrojejunal Ulcer

Symptoms & Phenotypes for Gastrojejunal Ulcer

MGI Mouse Phenotypes related to Gastrojejunal Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 ATP12A ATP4A F2 FFAR2 FFAR3 PTGS2
2 endocrine/exocrine gland MP:0005379 9.56 ATP4A CYP1A2 F2 FFAR2 FFAR3 PTGS2
3 homeostasis/metabolism MP:0005376 9.44 ATP12A ATP4A CYP1A2 F2 FFAR2 FFAR3

Drugs & Therapeutics for Gastrojejunal Ulcer

Drugs for Gastrojejunal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
2
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
3
Famotidine Approved Phase 4 76824-35-6 3325
4
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
5
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
6 Neurotransmitter Agents Phase 4
7 Histamine H2 Antagonists Phase 4
8
Histamine Phosphate Phase 4 51-74-1 65513
9 Histamine Antagonists Phase 4
10 Gastrointestinal Agents Phase 4
11 Proton Pump Inhibitors Phase 4
12 Antacids Phase 4
13 Anti-Ulcer Agents Phase 4
14 Narcotics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind Clinical Trial Comparing Zegerid Capsule to Famotidine in Preventing Anastomotic (Marginal) Ulcers in Post Gastric Bypass Patients Completed NCT00557349 Phase 4 Omeprazole;Famotidine
2 Prospective, Monocentric Study of Dexlansoprazole Absorption Preoperative and 6 and 12 Months After Proximal Roux-en-Y Gastric Bypass Surgery and of the Incidence of Marginal Ulcers 6 and 12 Months After Surgery Not yet recruiting NCT04423588 Phase 4
3 Laparoscopic Revision Gastric Bypass Surgery for Perforated Marginal Ulcer: A 10 Year Experience Completed NCT01041196
4 Laparoscopic Revision Gastric Bypass Surgery for Chronic Marginal Ulcers: a 10 Year Experience Completed NCT01041079
5 Endoscopic Therapy for Actively Bleeding Marginal Ulcers: Our Experience After 7,020 Roux-en-Y Gastric Bypass Surgeries Completed NCT01040416

Search NIH Clinical Center for Gastrojejunal Ulcer

Genetic Tests for Gastrojejunal Ulcer

Anatomical Context for Gastrojejunal Ulcer

MalaCards organs/tissues related to Gastrojejunal Ulcer:

40
Pancreas, Spleen, Heart, Kidney, Cervix

Publications for Gastrojejunal Ulcer

Articles related to Gastrojejunal Ulcer:

(show top 50) (show all 318)
# Title Authors PMID Year
1
Incidence and Prognostic Factors for the Development of Symptomatic and Asymptomatic Marginal Ulcers After Roux-en-Y Gastric Bypass Procedures. 61
33761070 2021
2
Anastomotic Gastrojejunal Ulcer Perforation Following One Anastomosis Gastric Bypass. 61
32948999 2021
3
Clinical and Endoscopic Predictors of Hydrostatic Balloon Dilation Failure for Post-Bariatric Anastomotic Stricture Treatment. 61
33761069 2021
4
Bridged one-anastomosis gastric bypass: technique and preliminary results. 61
33738583 2021
5
Risk factors for perforated marginal ulcers following pancreaticoduodenectomy and prospective analysis of marginal ulcer development. 61
33708556 2021
6
Marginal ulcer causing delayed anastomotic perforation following one anastomosis gastric bypass (OAGB). 61
33268323 2021
7
[Investigation of marginal ulcer after pancreatoduodenectomy]. 61
33431751 2021
8
Twenty years' experience of laparoscopic 1-anastomosis gastric bypass: surgical risk and long-term results. 61
33619007 2021
9
Super selective arterial embolization to treat radiation-induced hemorrhagic gastritis: a case report and review of the literature. 61
33380231 2021
10
Gastric pouch sero-myotomy for persistent dysphagia after roux-en-Y gastric bypass: Video report. 61
33321407 2021
11
Short- and long-term surgical outcomes of total pancreatectomy with islet autotransplantation: A comparative analysis of surgical technique and intraoperative heparin dosing to optimize outcomes. 61
33268025 2021
12
Laparoscopic conversion from mini gastric bypass/1 anastomosis gastric bypass to Roux-en-Y gastric bypass for perforated marginal ulcer: video case report. 61
33250081 2020
13
Which Factors Correlate with Marginal Ulcer After Surgery for Obesity? 61
32939660 2020
14
Correction to: "Which Factors Correlate with Marginal Ulcer After Surgery for Obesity?" 61
33044688 2020
15
Perforated Marginal Ulcer in a COVID-19 Patient. Laparoscopy in these Trying Times? 61
32447637 2020
16
Comparison of gastrojejunostomy techniques and anastomotic complications: a systematic literature review. 61
33159295 2020
17
Global Variations in Practices Concerning Roux-en-Y Gastric Bypass-an Online Survey of 651 Bariatric and Metabolic Surgeons with Cumulative Experience of 158,335 Procedures. 61
32592015 2020
18
Low Risk for Marginal Ulcers in Duodenal Switch and Gastric Bypass in a Well-Defined Cohort of 472 Patients. 61
32638248 2020
19
Pancreaticoduodenectomy for the treatment of pancreatic neoplasms in children: A Pediatric Surgical Oncology Research Collaborative study. 61
32658372 2020
20
One Anastomosis/Mini Gastric Bypass (OAGB-MGB) as revisional bariatric surgery after failed primary adjustable gastric band (LAGB) and sleeve gastrectomy (SG): A systematic review of 1075 patients. 61
32738545 2020
21
Short-term outcomes of the conversion of one anastomosis gastric bypass to Roux-en-Y gastric bypass in symptomatic reflux patients without revising the size of the gastric pouch. 61
32964872 2020
22
Outcomes of reoperative surgery in severely obese patients after sleeve gastrectomy: a single-institution experience. 61
32507733 2020
23
S146-Jejunojejunal intussusception after roux-En-Y gastric bypass: a case series of 34 patients. 61
32794044 2020
24
Laparoscopic Conversion of One Anastomosis Gastric Bypass to Roux-en-Y Gastric Bypass Due to Penetrated Marginal Ulcer. 61
32300946 2020
25
Symptomatic marginal ulcer after pancreatoduodenectomy. 61
32276736 2020
26
Upper endoscopy after Roux-en-Y gastric bypass: diagnostic yield and factors associated with relevant findings. 61
32299714 2020
27
Management of adverse events of EUS-directed transgastric ERCP procedure. 61
32529164 2020
28
The yield, effectiveness and safety of gastroscopy in management of early postbariatric upper gastrointestinal pain. 61
32550725 2020
29
Impact of truncal vagotomy on complicated peptic ulcer after distal gastrectomy with reconstruction by jejunal pouch interposition. 61
32488527 2020
30
Laparoscopic revision of a transected silastic vertical gastric bypass (Fobi pouch) with totally hand sewn gastrojejunostomy for complicated marginal ulcer. 61
32107169 2020
31
Minimally invasive Roux-en-Y reconstruction as a salvage operation after failed nissen fundoplication. 61
31346753 2020
32
Marginal ulceration following Roux-en-Y gastric bypass: risk factors for ulcer development, recurrence and need for revisional surgery. 61
32424625 2020
33
Acid-related complications after laparoscopic Roux-en-Y gastric bypass: risk factors and impact of proton pump inhibitors. 61
32107170 2020
34
Perforation of anastomotic peptic ulcer following pancreaticoduodenectomy: a report of three cases. 61
32306934 2020
35
Endoscopic Stents in the Management of Bariatric Complications: Our Algorithm and Outcomes. 61
31784894 2020
36
Analysis of Symptomatic Marginal Ulcers in Patients Who Underwent Pancreaticoduodenectomy for Periampullary Tumors. 61
32011522 2020
37
Accuracy of ICD-9 codes in identifying patients with peptic ulcer and gastrointestinal hemorrhage in the regional healthcare administrative database of Umbria. 61
32628718 2020
38
[Perforated Marginal Ulcer after Subtotal Stomach Preserving Pancreaticoduodenectomy-Report of Five Cases]. 61
32381890 2020
39
Successful closure with endoscopic suturing of a recalcitrant marginal ulcer despite Roux-en-Y gastric bypass reversion. 61
31844819 2019
40
Marginal ulcer continues to be a major source of morbidity over time following gastric bypass. 61
30543040 2019
41
One Anastomosis Gastric Bypass Versus Roux-en-Y Gastric Bypass for Morbid Obesity: an Updated Meta-Analysis. 61
31172454 2019
42
Efficiency and risks of laparoscopic conversion of omega anastomosis gastric bypass to Roux-en-Y gastric bypass. 61
30353237 2019
43
Reversal of Roux en Y gastric bypass: largest single institution experience. 61
31262648 2019
44
Evaluation of the rate of marginal ulcer formation after bariatric surgery using the MBSAQIP database. 61
30251139 2019
45
Laparoscopic loop duodenaljejunal bypass with sleeve gastrectomy in type 2 diabetic patients. 61
30935839 2019
46
Tailored One Anastomosis Gastric Bypass: 3-Year Outcomes of 94 Patients. 61
30430382 2019
47
Thoracoscopic truncal vagotomy versus surgical revision of the gastrojejunal anastomosis for recalcitrant marginal ulcers. 61
30132208 2019
48
Multimodal Postoperative Pain Control Is Effective and Reduces Opioid Use After Laparoscopic Roux-en-Y Gastric Bypass. 61
30317488 2019
49
Perioperative complications of sleeve gastrectomy: Review of the literature. 61
29737316 2019
50
Anastomotic Strictures After Roux-en-Y Gastric Bypass: a Cohort Study from the Scandinavian Obesity Surgery Registry. 61
30206785 2019

Variations for Gastrojejunal Ulcer

Expression for Gastrojejunal Ulcer

Search GEO for disease gene expression data for Gastrojejunal Ulcer.

Pathways for Gastrojejunal Ulcer

Pathways related to Gastrojejunal Ulcer according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 11.8 SLC6A4 PTGS2 CYP2C9
2
Show member pathways
11.62 PTGS2 CYP3A4 CYP2C9 CYP1A2
3
Show member pathways
11.5 SLC6A4 CYP3A4 CYP2C9 CYP1A2
4
Show member pathways
11.49 CYP3A4 CYP2C9 CYP1A2
5
Show member pathways
11.46 CYP3A4 CYP2C9 CYP1A2
6
Show member pathways
11.39 CYP3A4 CYP2C9 CYP1A2
7
Show member pathways
11.2 CYP3A4 CYP2C9 CYP1A2
8 11.12 CYP3A4 CYP2C9 CYP1A2
9
Show member pathways
11.09 CYP3A4 CYP2C9 CYP1A2
10
Show member pathways
11.03 CYP3A4 CYP2C9 CYP1A2
11 10.95 CYP3A4 CYP1A2
12 10.88 CYP3A4 CYP2C9
13
Show member pathways
10.76 CYP3A4 CYP1A2
14 10.72 VKORC1 F2
15 10.71 PTGS2 CYP3A4
16 10.63 F2 CYP3A4 CYP2C9 CYP1A2
17
Show member pathways
10.57 CYP3A4 CYP2C9
18 10.51 CYP3A4 CYP2C9 CYP1A2
19 10.16 FFAR3 FFAR2

GO Terms for Gastrojejunal Ulcer

Cellular components related to Gastrojejunal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.43 VKORC1 PTGS2 NTS CYP3A4 CYP2C9 CYP1A2
2 organelle membrane GO:0031090 8.92 PTGS2 CYP3A4 CYP2C9 CYP1A2

Biological processes related to Gastrojejunal Ulcer according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.03 VKORC1 PTGS2 CYP3A4 CYP2C9 CYP1A2
2 response to organic cyclic compound GO:0014070 9.81 VKORC1 PTGS2 CYP1A2
3 steroid metabolic process GO:0008202 9.8 CYP3A4 CYP2C9 CYP1A2
4 response to estradiol GO:0032355 9.79 SLC6A4 PTGS2 CYP1A2
5 cholesterol metabolic process GO:0008203 9.79 CYP3A4 CYP2C9 CYP1A2
6 xenobiotic metabolic process GO:0006805 9.77 CYP3A4 CYP2C9 CYP1A2
7 response to organic substance GO:0010033 9.74 SLC6A4 PTGS2 CYP1A2
8 estrogen metabolic process GO:0008210 9.65 CYP3A4 CYP2C9 CYP1A2
9 epoxygenase P450 pathway GO:0019373 9.64 CYP2C9 CYP1A2
10 cellular sodium ion homeostasis GO:0006883 9.64 ATP4A ATP12A
11 sodium ion export across plasma membrane GO:0036376 9.61 ATP4A ATP12A
12 cellular potassium ion homeostasis GO:0030007 9.6 ATP4A ATP12A
13 regulation of blood coagulation GO:0030193 9.58 VKORC1 F2
14 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.58 ATP4A ATP12A
15 omega-hydroxylase P450 pathway GO:0097267 9.56 CYP2C9 CYP1A2
16 positive regulation of cytokine production involved in immune response GO:0002720 9.55 FFAR3 FFAR2
17 heterocycle metabolic process GO:0046483 9.54 CYP3A4 CYP1A2
18 exogenous drug catabolic process GO:0042738 9.54 CYP3A4 CYP2C9 CYP1A2
19 mucosal immune response GO:0002385 9.52 FFAR3 FFAR2
20 steroid catabolic process GO:0006706 9.51 CYP3A4 CYP1A2
21 oxidative demethylation GO:0070989 9.5 CYP3A4 CYP2C9 CYP1A2
22 monocarboxylic acid metabolic process GO:0032787 9.49 CYP2C9 CYP1A2
23 regulation of peptide hormone secretion GO:0090276 9.46 FFAR3 FFAR2
24 negative regulation of synaptic transmission, dopaminergic GO:0032227 9.43 SLC6A4 PTGS2
25 drug catabolic process GO:0042737 9.43 CYP3A4 CYP2C9 CYP1A2
26 positive regulation of acute inflammatory response to non-antigenic stimulus GO:0002879 9.4 FFAR3 FFAR2
27 monoterpenoid metabolic process GO:0016098 9.33 CYP3A4 CYP2C9 CYP1A2
28 drug metabolic process GO:0017144 9.26 VKORC1 CYP3A4 CYP2C9 CYP1A2
29 long-chain fatty acid biosynthetic process GO:0042759 8.92 PTGS2 CYP3A4 CYP2C9 CYP1A2

Molecular functions related to Gastrojejunal Ulcer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.91 VKORC1 PTGS2 CYP3A4 CYP2C9 CYP1A2
2 iron ion binding GO:0005506 9.7 CYP3A4 CYP2C9 CYP1A2
3 monooxygenase activity GO:0004497 9.67 CYP3A4 CYP2C9 CYP1A2
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.63 CYP3A4 CYP2C9 CYP1A2
5 heme binding GO:0020037 9.62 PTGS2 CYP3A4 CYP2C9 CYP1A2
6 sodium:potassium-exchanging ATPase activity GO:0005391 9.48 ATP4A ATP12A
7 estrogen 16-alpha-hydroxylase activity GO:0101020 9.43 CYP3A4 CYP1A2
8 potassium-transporting ATPase activity GO:0008556 9.4 ATP4A ATP12A
9 estrogen 2-hydroxylase activity GO:0101021 9.37 CYP3A4 CYP1A2
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.33 CYP3A4 CYP2C9 CYP1A2
11 potassium:proton exchanging ATPase activity GO:0008900 9.26 ATP4A ATP12A
12 aromatase activity GO:0070330 9.13 CYP3A4 CYP2C9 CYP1A2
13 caffeine oxidase activity GO:0034875 8.8 CYP3A4 CYP2C9 CYP1A2

Sources for Gastrojejunal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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